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https://www.readbyqxmd.com/read/29781070/antiplatelet-therapy-for-patients-undergoing-coronary-artery-bypass-surgery
#1
Christine M DeStephan, David J Schneider
Considerable variation in the use and duration of antiplatelet medications during the perioperative and postoperative care of patients undergoing coronary artery bypass grafting (CABG) reflects limited studies focused directly on these patients as well as variation in the results reported. In this review we will highlight the incidence and mechanisms of graft closure as well as the evidence in support of antiplatelet therapy that is balanced by the impact of antiplatelet therapy on the risk of bleeding to provide recommendations for the use of antiplatelet therapy in patients undergoing CABG...
May 21, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29781069/dual-and-triple-antithrombotic-therapies-current-patterns-of-practice-and-controversies
#2
Mark Crowther, John Eikelboom
Dual antiplatelet therapy (DAPT) has been the cornerstone of antithrombotic management for patients undergoing percutaneous coronary intervention (PCI). Despite low-quality evidence, triple antithrombotic therapy involving acetylsalicylic acid, clopidogrel and warfarin or non-vitamin K antagonist oral anticoagulant (NOAC) has been recommended in patients with concomitant atrial fibrillation undergoing PCI, who require long-term oral anticoagulation, although such strategy is associated with a substantially increased risk of bleeding compared with DAPT...
May 21, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29780645/sustained-regression-of-hydroxycarbamide-induced-actinic-keratoses-after-switching-to-anagrelide
#3
Georgios Gaitanis, Dora Gougopoulou, Eleni Kapsali, Ioannis D Bassukas
Hydroxycarbamide (HC) is the first-line treatment for certain myeloproliferative neoplasms, such as polycythemia vera and essential thrombocytosis (ET). In a subset of these patients long-term treatment with HC can result in the development of confluent actinic keratoses (AK) followed by invasive keratinocytic carcinomas ("squamous dysplasia"), preferentially on sun-exposed skin. Discontinuation or dose reduction of HC may result in partial improvement. A 59-year-old farmer after 14 years on HC (2 gr/d) and acetylsalicylic acid (100 mg/d) for ET, was referred for numerous, hyperkeratotic AK on face, scalp, and hands that could not be controlled with repeated ( N = 15) cryosurgery sessions in the previous 3 years...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29768160/-selection-of-antiplatelet-therapy-for-patients-with-stable-angina
#4
M V Arkhipov
Acetylsalicylic acid (ASA) has a 120‑years long history. First ASA was used as an antipyretic and anesthetic medicine, nowadays it is widely prescribed to patients with coronary arteries disease as antithrombotic cure for prevention of major adverse clinical events (MACE). Though there are a lot of trials about usage of ASA for first and secondary MACE prevention still there are unmet clinical needs - dosage choice, the therapy length, diagnostic and management of ASA resistance, and also the prophylaxis of gastro-enteric hemorrhages...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29758501/rolling-made-gas-diffusion-electrode-with-carbon-nanotube-for-electro-fenton-degradation-of-acetylsalicylic-acid
#5
Huijia Yang, Minghua Zhou, Weilu Yang, Gengbo Ren, Liang Ma
H2 O2 production plays an important role in electro-Fenton process for pharmaceutical and personal care products (PPCPs) degradation. In this work, carbon nanotube (CNT) was attempted to make a gas diffusion electrode (GDE) by rolling method to achieve a high H2 O2 production and current efficiency, and it was further used as electro-Fenton cathode for the degradation of acetylsalicylic acid (ASA) as one kind of PPCPs. The optimal amount of catalyst layer was 0.15 g CNT and 93.75 μL PTFE, obtaining the production of H2 O2 of 805 mg L-1 in 0...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29754149/the-role-of-dipyrone-in-the-high-development-of-on-treatment-platelet-reactivity-in-acetylsalicylic-acid-treated-patients-undergoing-peripheral-artery-revascularization
#6
Jan Hartinger, Robert Novotny, Jana Bilkova, Tomas Kvasnicka, Petr Mitas, Martin Sima, Jaroslav Hlubocky, Jan Kvasnicka, Ondrej Slanar, Jaroslav Lindner
OBJECTIVE: To evaluate the effects of dipyrone on sensitivity to Aspirin [acetyl salicylic acid, (ASA)] in patients who underwent peripheral artery vascular reconstruction. SUBJECTS AND METHODS: Impedance aggregometry and light transmission aggregometry were used to determine the effects of dipyrone on ASA treatment in 21 patients. Blood samples were drawn in a 7-day period after the surgery. The cut-off value for high on-treatment platelet reactivity (HTPR) was set at < 65% of aggregation inhibition for impedance aggregometry...
May 13, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29751307/systematic-screening-and-identification-of-the-chlorinated-transformation-products-of-aromatic-pharmaceuticals-and-personal-care-products-using-high-resolution-mass-spectrometry
#7
Wen-Ling Chen, Jiun-Yi Cheng, Xiao-Qian Lin
Pharmaceuticals and personal care products (PPCPs) are an emerging concern because of the large amount of PPCPs that is discharged and its potential ecological effects on the aquatic environment. Chlorination has proven efficient for removing some aromatic PPCPs from wastewater, but the formation of by-products has not been thoroughly investigated partly because of analytical difficulties. This study developed a method for systematically screening and identifying the transformation products (TPs) of multiple aromatic PPCPs through high-resolution mass spectrometry (HRMS)...
May 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29734325/-mesotherapy-as-a-treatment-of-pain-and-disability-in-patients-affected-by-neck-pain-in-spondylartrosis
#8
Rossella Viscito, Paola Emilia Ferrara, Concetta Ljoka, Romina Pascuzzo, Loredana Maggi, Gianpaolo Ronconi, Calogero Foti
Mesotherapy is a technique that treats locoregional pain with intradermal injection of a drug in the affected area. Its short-term efficacy was observed in patients with low back pain using both normal saline solution, if there were contraindications to drugs' use, or a cocktail of drugs (normal saline solution, lidocaine hydrochloride, and lysine acetylsalicylate), whereas only the latter provided benefit for up to three months after treatment. The aim of this study was to measure the effects of mesotherapy in patients affected by neck pain in spondylarthrosis, a common pathology in rehabilitation, associated with significant disability and increased health expenditure...
January 2018: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29722860/oesophageal-injury-following-magnetically-guided-single-catheter-ablation-for-atrial-fibrillation-insights-from-the-magna-af-registry
#9
Dirk Bastian, Johannes Schwab, Karl-Theodor Steurer, Andrea Brinker-Paschke, Arno Boessenecker, Reinhard Doering, Zeynep Karakurt, Laura Vitali-Serdoz, Matthias Pauschinger, Konrad Göhl
Aims: Oesophagogastroduodenoscopy (OGD) after catheter ablation (CA) of atrial fibrillation (AF) revealed a high rate of procedure related oesophageal lesions. We hypothesized that magnetically guided CA with careful radiofrequency energy titration at the posterior left atrial (LA) wall limits the incidence of oesophageal tissue damage. Methods and results: As a part of the prospective "Remote MAGNetic catheter Ablation for Atrial Fibrillation" (MAGNA-AF) registry, 251 out of 266 consecutive patients underwent OGD after magnetically guided single-CA for AF...
May 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29721002/should-atrial-fibrillation-patients-with-hypertension-as-an-additional-risk-factor-of-the-cha2ds2-vasc-score-receive-oral-anticoagulation
#10
REVIEW
Juan Wang, Da-Peng Zhang, Hong-Bin Liu, Jiu-Chang Zhong, Xin-Chun Yang
Hypertension has been found to be increased a risk of stroke in atrial fibrillation (AF). Both the European and U.S. guidelines advocate the use of the CHA2 DS2 -VASc (congestive heart failure, hypertension, age > 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category) scheme for risk stratification. Although vitamin K antagonists is more effective than acetylsalicylic acid at preventing ischaemic stroke, its benefit is offs by an increased haemorrhage risk...
March 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29720770/application-of-x-ray-powder-diffraction-and-differential-scanning-calorimetry-for-identification-of-counterfeit-drugs
#11
Izabela Jendrzejewska, Paweł Zajdel, Ewa Pietrasik, Zoja Barsova, Tomasz Goryczka
X-ray analysis confirmed that in all investigated samples, the active API (acetylsalicylic acid and ascorbic acid) was present. The values of the interplanar distance d hkl for the studied samples are in good accordance with those presented in the ICDD database. The intensities of the diffraction lines depend on the content of the component in the tested preparation. Therefore, different intensities of lines for the APIs were observed in the obtained diffraction patterns. Thermal analysis of the studied substances showed that during the thermal analysis, the following phenomena might occur: dehydration and (or) melting, crystalline transformation...
2018: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/29717365/the-who-diagnostic-criteria-for-polycythemia-vera-role-of-red-cell-mass-versus-hemoglobin-hematocrit-level-and-morphology
#12
Ljubomir Jakovic, Mirjana Gotic, Heinz Gisslinger, Ivan Soldatovic, Dijana Sefer, Mila Tirnanic, Danijela Lekovic, Maja Perunicic Jovanovic, Martin Schalling, Bettina Gisslinger, Christine Beham-Schmid, Ingrid Simonitsch-Klupp, Jürgen Thiele
Regarding diagnosis of polycythemia vera (PV), discussion persists about hemoglobin (Hb) and/or hematocrit (Hct) threshold values as surrogate markers for red cell mass (RCM) and the diagnostic impact of bone marrow (BM) morphology. We performed a retrospective study on 290 patients with PV (151 males, 139 females; median age 65 years) presenting with characteristic BM features (initial biopsies, centralized evaluation) and endogenous erythroid colony (EEC) formations. This cohort included (1) a group of 229 patients when following the 2008 versus 256 patients diagnosed according to the 2016 World Health Organization (WHO) guidelines, all presented with increased RCM; (2) masked PV patients with low Hb (n = 143)/Hct (n = 45) recruited from the 2008 WHO cohort; (3) a cohort of 17 PV patients with elevated diagnostic Hb/Hct levels but low RCM; and (4) nine PV patients with increased RCM, opposing low Hb/Hct values...
May 1, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29707104/the-effects-of-synthesized-rhenium-acetylsalicylate-compounds-on-human-astrocytoma-cell-lines
#13
Hirendra N Banerjee, Deidre Vaughan, Ava Boston, Gabriel Thorne, Gloria Payne, Josiah Sampson, Vinod Manglik, Pola Olczak, Brent V Powell, Angela Winstead, Roosevelt Shaw, Santosh K Mandal
Purpose: Because of the scarcity of suitable brain cancer drugs, researchers are frantically trying to discover novel and highly potent drugs free of side effects and drug-resistance. Rhenium compounds are known to be nontoxic and exhibit no drug resistance. For that reason, we have developed a series of novel rhenium acetylsalicylato (RAC or ASP) complexes to test their cytotoxicity on brain cancer cells. Also we have attempted to explore the DNAbinding properties of these compounds because many drugs either directly or indirectly bind to DNA...
2018: Journal of Cancer Science & Therapy
https://www.readbyqxmd.com/read/29702713/predictors-of-bleeding-in-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-using-the-health-improvement-network-in-the-united-kingdom
#14
Lucía Cea Soriano, F Gerry R Fowkes, Alaster M Allum, Saga Johansson, Luis A García Rodriguez
The purpose of this analysis was to assess potential predictors of intra-cranial bleeding (ICB) and gastrointestinal bleeding (GIB) in patients with symptomatic peripheral artery disease (PAD) in UK primary care. Patients with symptomatic PAD diagnosed from 2000 to 2010 were identified from The Health Improvement Network (THIN; N  = 28,484). A nested case-control analysis, adjusted for potential confounders, was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for potential predictors of ICB or GIB...
April 27, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29674078/determination-of-four-salicylic-acids-in-aloe-by-in-vivo-solid-phase-microextraction-coupling-with-liquid-chromatography-photodiode-array-detection
#15
Xu'an Fang, Guosheng Chen, Junlang Qiu, Jianqiao Xu, Junhui Wang, Fang Zhu, Gangfeng Ouyang
In recent years, great concerns have been raised about salicylic acid (SA) and its derivatives as plant regulators. Therefore, precise determination of the distribution of SAs in the living plants is necessary for not only fundamental researches but also the regulating mechanisms. In this study, a custom-made solid phase microextraction (SPME) fiber based on diallyl dimethyl ammonium chloride-assembled graphene oxide-coated C18 composite (C18@GO@PDDA) was proposed for in vivo detection of salicylic acid, acetylsalicylic acid (ASA), 4-methyl salicylic acid(4-SA)and 3-methyl salicylic acid (3-SA) in aloe plants...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671011/-rectal-bleeding-in-a-60-year-old-woman-under-anticoagulation-and-platelet-aggregation-inhibition
#16
J Pohlan, N Willamowski, C Jürgensen, E Zimmermann, M Möckel
CASE REPORT: We report on a woman with lower gastrointestinal bleeding under effective oral anticoagulation with both phenprocoumon and apixaban (with intention to switch to the latter) as well as the antiplatelet agent acetylsalicylic acid for aortic bifurcation kissing stents after stent thrombosis. Our patient presented with weakness and rectal bleeding. Upon examination, she looked anemic and had sinus tachycardia (104 beats per minute). The digital rectal examination revealed bright red blood mixed with clots...
April 18, 2018: Der Internist
https://www.readbyqxmd.com/read/29669671/drug-induced-eosinophilia
#17
Christine Rauscher, Allison Freeman
BACKGROUND: Drug reactions have been associated with increased blood eosinophil levels. OBJECTIVE: To review clinical characteristics, the diagnosis, and the management of drug-induced eosinophilia. METHODS: Pertinent articles were selected and reviewed in relation to a case presentation of drug-induced eosinophilia. RESULTS: A case of asymptomatic eosinophilia in the setting of acetylsalicylic acid (aspirin) use was presented, followed by discussion of the clinical characteristics, diagnosis, and management of drug-induced eosinophilia...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29669404/patients-with-platelet-aggregation-inhibitors-in-the-dental-office
#18
Ayhan Yildirim, Heinz-Theo Lübbers, Ali Yildirim
Antiplatelet agents with the active ingredients acetylsalicylic acid (Aspirin® protect 100), clopidogrel (Iscover®, Plavix®), prasugrel (Efient®) or ticagrelor (Brilique™) prevent the clumping of platelets and thus the formation of small clots at constrictions of the coronary arteries or on the metal struts of stents in the coronary artery or in bypass grafts. Large-scale studies have shown that taken regularly, these drugs can extend life and help prevent heart attacks. Especially in patients with newly implanted stents, the combination of the above-mentioned agents prevents sudden complete occlusion of the vessel concerned...
April 15, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#19
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29659773/gut-barrier-dysfunction-a-primary-defect-in-twins-with-crohn-s-disease-predominantly-caused-by-genetic-predisposition
#20
Åsa V Keita, Mårten Carl Lindqvist, Åke Öst, Carlos D L Magana, Ida Schoultz, Jonas Halfvarson
Background and aims: The aetiology of Crohn's disease is poorly understood. By investigating twin pairs discordant for Crohn's disease we aimed to assess if the dysregulated barrier represents a cause or a consequence of inflammation and to evaluate the impact of genetic predisposition on barrier function. Methods: Ileal biopsies from 15 twin pairs discordant for Crohn's disease (monozygotic n=9, dizygotic n=6) and 10 external controls were mounted in Ussing chambers to assess paracellular permeability to51Chromium (Cr)-EDTA and trancellular passage to non-pathogenic E...
April 12, 2018: Journal of Crohn's & Colitis
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