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https://www.readbyqxmd.com/read/28520861/influence-of-practice-patterns-on-outcome-among-countries-enrolled-in-the-syntax-trial-5-year-results-between-percutaneous-coronary-intervention-and-coronary-artery-bypass-grafting%C3%A2
#1
Milan Milojevic, Stuart J Head, Michael J Mack, Friedrich W Mohr, Marie-Claude Morice, Keith D Dawkins, David R Holmes, Patrick W Serruys, Arie Pieter Kappetein
OBJECTIVES: To examine differences among participating countries in baseline characteristics, clinical practice, medication strategies and outcomes of patients randomized to coronary artery bypass grafting and percutaneous coronary intervention in the SYNTAX trial. METHODS: In SYNTAX, centres in 18 different countries enrolled 1800 patients, of which 8 countries enrolled ≥80 patients, what was projected to be a large enough sample size to be included in the analysis...
May 16, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28516318/effect-of-apixaban-on-all-cause-death-in-patients-with-atrial-fibrillation-a-meta-analysis-based-on-imputed-placebo-effect
#2
Patrícia O Guimarães, Renato D Lopes, Daniel M Wojdyla, Azmil H Abdul-Rahim, Stuart J Connolly, Greg C Flaker, Junyuan Wang, Michael Hanna, Christopher B Granger, Lars Wallentin, Kennedy R Lees, John H Alexander, John J V McMurray
PURPOSE: Vitamin K antagonists (VKAs) are the standard of care for stroke prevention in patients with atrial fibrillation (AF); therefore, there is not equipoise when comparing newer oral anticoagulants with placebo in this setting. METHODS: To explore the effect of apixaban on mortality in patients with AF, we performed a meta-analysis of apixaban versus placebo using a putative placebo analysis based on randomized controlled clinical trials that compared warfarin, aspirin, and no antithrombotic control...
May 18, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28506390/assessment-of-pharmacokinetic-interaction-between-omega-3-carboxylic-acids-and-the-statins-rosuvastatin-and-simvastatin-results-of-2-phase-i-studies-in-healthy-volunteers
#3
Elliot Offman, Michael Davidson, Catarina Nilsson
BACKGROUND: Omega-3 carboxylic acids (OM3-CA) can lower triglyceride levels. OM3-CA is often prescribed concomitantly with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin). OBJECTIVE: The aim of the article was to assess the potential for pharmacokinetic interaction between OM3-CA and the statins rosuvastatin and simvastatin. METHODS: Data from 2 phase I studies (ECLIPSE III and OM-EPA-007 [NCT01486433]) were analyzed. In ECLIPSE III, 59 participants received OM3-CA 4 g once daily for 13 days, with rosuvastatin 40 mg (single dose) co-administered with the 11th dose...
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28474976/iliac-artery-reconstruction-with-the-superficial-femoral-vein-after-major-oncologic-resection
#4
Leopoldo Fernández-Alonso, Sebastian Fernández-Alonso, Esther Martínez Aguilar
The large size of some retroperitoneal tumors and the complex anatomy of the retroperitoneal structures often require en bloc resection of contiguous organs and, sometimes, resection of critical vascular structures. Vascular reconstructive techniques allow reconstruction of major vascular structures, and autologous vein grafting is the preferred option. Although great saphenous vein can be used in select cases, other options must be explored in cases of caliber mismatch between saphenous vein and native vessel...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28466125/effect-of-anticoagulation-therapy-on-drying-times-in-bloodstain-pattern-analysis
#5
Frank Ramsthaler, Ann-Katrin Kröll, Marcel Verhoff, Christoph G Birngruber, Mattias Kettner
In forensic case work, blood stain pattern analysis frequently aids in deducing the chain of actions or parts thereof taking place during an event leading to blood loss. Wiped single blood stains and/or groups of blood stains are seen at a majority of complex crime scenes. The appearance of wiped blood stains depends on droplet volume and stain age (as a function of blood viscosity and the degree of stain skeletonization) and characteristics of the stained surface (i.e., texture, temperature). Furthermore, based on the biochemical and biophysical properties of blood, not only the drying processes, but also complex coagulation cascades are relevant to the assessment of wiped blood stains...
May 2, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28465804/atypical-desquamation-in-a-2-5-year-old-boy-with-kawasaki-disease-a-case-report
#6
Ali Adib, Ali Fazel, Seyed Hesamedin Nabavizadeh, Sohaila Alyasin, Sara Kashef
Kawasaki disease (KD) is a vasculitis that mostly affects children under 5 years of age. This article presents a 2.5-year-old boy who presented with 6 days of fever, generalized maculopapular rash, bilateral non-exudative conjunctivitis, cracked lips, right cervical lymphadenopathy, erythematous extremities, and perianal desquamation. Laboratory studies showed leukocytosis and sterile pyuria. Because diagnosis of KD was proved, oral acetylsalicylic acid with the anti-inflammatory dose and intravenous immunoglobulin were started for him...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28463766/one-step-synthesis-of-porous-copper-oxide-for-electrochemical-sensing-of-acetylsalicylic-acid-in-the-real-sample
#7
Mani Sivakumar, Mani Sakthivel, Shen-Ming Chen, Yi-Hui Cheng, Karuppiah Pandi
A Facile approach of one-step synthesis was employed to prepare porous CuO at different annealing temperature and characterized by using numerous analytical techniques. Moreover, the electrochemical sensing application of CuO modified glassy carbon electrode was studied and recorded using various electrochemical techniques. From the results, it was interpreted that the CuO prepared at 350°C exhibits satisfactorily electrochemical determination of Acetylsalicylic acid (ASA) with unique sensitivity, linear range and limit of detection of about 831...
April 25, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28460044/risk-factors-for-upper-gastrointestinal-bleeding-in-patients-taking-selective-cox-2-inhibitors-a-nationwide-population-based-cohort-study
#8
Xi-Hsuan Lin, Shih-Hao Young, Jiing-Chyuan Luo, Yen-Ling Peng, Ping-Hsien Chen, Chung-Chi Lin, Wei-Ming Chen, Ming-Chih Hou, Fa-Yauh Lee
Objective.:  Cyclooxygenase-2 inhibitors (coxibs) are associated with less upper gastrointestinal bleeding (UGIB) than traditional nonsteroidal anti-inflammatory drugs (tNSAIDs). However, they also increase the risk of UGIB in high-risk patients. We aimed to identify the risk factors of UGIB in coxibs users. Design. : Retrospective cohort study. Setting. : 2000-2010 National Health Insurance Research Database of Taiwan. Subjects...
April 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28456486/sodium-salicylate-inhibits-urokinase-activity-in-mda-mb-231-breast-cancer-cells
#9
Josip Madunić, Luka Horvat, Ivana Majstorović, Iga Jodłowska, Mariastefania Antica, Maja Matulić
INTRODUCTION: Sodium salicylate (NaS) is a derivate of acetylsalicylic acid or aspirin, used as a nonsteroidal anti-inflammatory drug for centuries, for its analgesic and anti-inflammatory effects. It was found to modulate different signaling pathways, in a cell-specific way. Here, we explore the effect of NaS on cell growth and urokinase activity in MDA MB-231 breast cancer cells. MATERIALS AND METHODS: We analyzed the effect of NaS treatment on cell growth by flow cytometry and viability test...
April 6, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28453742/blinded-contractility-analysis-in-hipsc-cardiomyocytes-in-engineered-heart-tissue-format-comparison-with-human-atrial-trabeculae
#10
Ingra Mannhardt, Alexandra Eder, Berengere Dumotier, Maksymilian Prondzynski, Elisabeth Krämer, Martin Traebert, Klaus-Dieter Söhren, Frederik Flenner, Konstantina Stathopoulou, Marc D Lemoine, Lucie Carrier, Torsten Christ, Thomas Eschenhagen, Arne Hansen
Objective: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) may serve as a new assay for drug testing in a human context, but their validity particularly for the evaluation of inotropic drug effects remains unclear. In this blinded analysis, we compared the effects of 10 indicator compounds with known inotropic effects in electrically stimulated (1.5 Hz) hiPSC-CM-derived 3 dimensional engineered heart tissue (EHT) and human atrial trabeculae (hAT). Methods and results: Human EHTs were prepared from iCell® hiPSC-CM, hAT obtained at routine heart surgery...
April 27, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28451776/acetylsalicylic-acid-tris-hydroxymethyl-aminomethane-reduces-colon-mucosal-damage-without-causing-gastric-side-effects-in-a-rat-model-of-colitis
#11
Gabriella Varga, Melinda Ugocsai, Petra Hartmann, Norbert Lajkó, Réka Molnár, Szilárd Szűcs, Dávid Kurszán Jász, Dániel Érces, Miklós Ghyczy, Gábor Tóth, Mihály Boros
BACKGROUND: We have developed a novel compound from acetylsalicylic acid (ASA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) precursors with ASA-like anti-inflammatory efficacy and reduced the mucosa-damaging side-effects. Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment. METHODS: Sprague-Dawley rats were randomized to five groups (n = 6, each), and TNBS enemas were performed...
April 27, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28446026/medical-therapy-before-carotid-endarterectomy
#12
Daniele Bissacco, Michele Carmo, Iacopo Barbetta, Raffaello Dallatana, Piergiorgio G Settembrini
We evaluated the evolution of chronic medical therapy in patients admitted for carotid endarterectomy (CEA) over a 13-year period and to analyze the difference in medical treatment between symptomatic and asymptomatic patients. A retrospective study was conducted on patients treated between 2002 and 2015. The use of antiplatelets (acetylsalicylic acid [ASA], ticlopidine, and clopidogrel), oral anticoagulant therapy (OAT), statins and antihypertensives (angiotensin-converting enzyme inhibitors [ACE-I]/angiotensin receptor blockers [ARBs], β-blockers [BB]) administration was evaluated...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28445845/the-capacity-and-effectiveness-of-diosmectite-and-charcoal-in-trapping-the-compounds-causing-the-most-frequent-intoxications-in-acute-medicine-a-comparative-study
#13
Michaela Mináriková, Veronika Fojtikova, Eliška Vyskočilová, Jan Sedláček, Milan Šikut, Lucie Borek-Dohalska, Marie Stiborová, Marketa Martinkova
The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenobarbital, ibuprofen, imipramine, carbamazepine, oxazepam, promethazine, and theophylline. Of the tested compounds, promethazine and imipramine were the most effectively adsorbed to diosmectite. Their adsorption to diosmectite (0...
April 17, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28435120/the-role-of-platelets-in-hemostasis-and-the-effects-of-snake-venom-toxins-on-platelet-function
#14
REVIEW
Mayara Ribeiro de Queiroz, Bruna Barbosa de Sousa, Déborah Fernanda da Cunha Pereira, Carla Cristine Neves Mamede, Mariana Santos Matias, Nadia Cristina Gomes de Morais, Júnia de Oliveira Costa, Fábio de Oliveira
The human body has a set of physiological processes, known as hemostasis, which keeps the blood fluid and free of clots in normal vessels; in the case of vascular injury, this process induces the local formation of a hemostatic plug, preventing hemorrhage. The hemostatic system in humans presents complex physiological interactions that involve platelets, plasma proteins, endothelial and subendothelial structures. Disequilibrium in the regulatory mechanisms that control the growth and the size of the thrombus is one of the factors that favors the development of diseases related to vascular disorders such as myocardial infarction and stroke, which are among the leading causes of death in the western world...
April 20, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28433767/temporal-dynamics-of-human-excreted-pollutants-in-wastewater-treatment-plant-influents-toward-a-better-knowledge-of-mass-load-fluctuations
#15
Thomas Thiebault, Laëtitia Fougère, Emilie Destandau, Maxime Réty, Jérémy Jacob
The occurrence of 25 drug target residues (illicit drugs or pharmaceutically active compounds) was investigated during 85 consecutive days in the influents of a wastewater treatment plant in the Region Centre-Val de Loire, France. This long tracking period allowed a better understanding of the patterns affecting the occurrence of this type of contaminants. Among them, 2 were never detected (i.e. heroin and amphetamine). Concerning illicit drugs two patterns were found. Cocaine and ecstasy median loads varied considerably between weekdays and weekend days (i...
April 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28433637/inhibition-of-pro-inflammatory-enzymes-by-medicinal-plants-from-the-argentinean-highlands-puna
#16
Romina Torres-Carro, María Inés Isla, Samanta Thomas-Valdes, Felipe Jiménez-Aspee, Guillermo Schmeda-Hirschmann, María Rosa Alberto
ETHNOPHARMACOLOGICAL RELEVANCE: Human groups in the Argentinean Andes highlands (Puna) selected native plants as anti-inflammatory agents. The indications of use are mainly to relieve pain, in infusions, ethanolic extracts or plasters. AIM OF THE STUDY: The objective of the study was to assess the effect of hydroalcoholic extracts from native highland plants as anti-inflammatory according to the traditional indications of use. The chemical profile of the three most active species was analyzed by HPLC-ESI-MS to get in insight into the constituents and the effects observed, according to the ethnopharmacological information...
April 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28429213/effect-of-compound-sbt-828-a-new-indole-derivative-exhibiting-antiaggregant-activity-on-the-prostacyclin-thromboxane-a2-balance
#17
A F Kucheryavenko, A A Spasov, M Tian, K F Suzdalev
We investigated the effect of a new indole derivative Sbt-828 with antiaggregant properties on prostacyclin-generating activity of the vascular wall and thromboxane A2 level in platelets of intact rats. The substance under study did not affect prostacyclin production by the vascular wall and significantly reduced thromboxane A2 level, being superior to the reference drug acetylsalicylic acid by 1.6 times, as seen from reduced malonic dialdehyde level in the thrombin-induced rat platelets.
April 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28429121/renovascular-hypertension-results-in-adulthood-of-renal-autotransplantation-performed-in-children
#18
Bertrand Chavent, Ambroise Duprey, Marie-Pierre Lavocat, Christine Fichtner, Anne-Marie Beraud, Jean-Noel Albertini, Jean-Pierre Favre, Nicolas Maillard, Xavier Barral
BACKGROUND: This study describes the long-term results of renal autotransplantation for renovascular hypertension performed in children who are now 21 years of age or older. METHODS: Sixteen children (4 boys, 12 girls) with a mean age of 11.2 years at the time of the procedure underwent ex-vivo surgery at the university hospital of Saint-Etienne between 1992 and 2008. Acetylsalicylic acid was used for antiplatelet therapy in the postoperative period, without routine anticoagulation...
April 20, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28425247/meloxicam-and-diclofenac-do-not-change-vegf-and-pdgf-abserum-levels-of-platelet-rich-plasma
#19
Burkay Utku, Gürhan Dönmez, Gülriz Erişgen, Şenay Akin, Haydar Ali Demirel, Feza Korkusuz, Mahmut Nedim Doral
BACKGROUND/AIM: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. MATERIALS AND METHODS: Two different final concentrations of diclofenac (0...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28418802/transfer-of-low-dose-aspirin-into-human-milk
#20
Palika Datta, Kathleen Rewers-Felkins, Raja Reddy Kallem, Teresa Baker, Thomas W Hale
BACKGROUND: Aspirin has antipyretic and anti-inflammatory properties and is frequently used by pregnant and lactating women. However, its transfer in human milk when administered at low dose has not been reported. Research aim: This study aimed to evaluate the transfer of acetylsalicylic acid and its metabolite, salicylic acid, into human milk following the use of low dose aspirin. METHODS: In this study, milk samples were collected at 0, 1, 2, 4, 8, 12, and 24 hours from seven breastfeeding women after a steady-state daily dose of 81 mg of aspirin...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
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