keyword
https://read.qxmd.com/read/36694135/molecular-characterization-reveals-that-ossapk3-improves-drought-tolerance-and-grain-yield-in-rice
#21
JOURNAL ARTICLE
Dengji Lou, Suping Lu, Zhen Chen, Yi Lin, Diqiu Yu, Xiaoyan Yang
BACKGROUND: Many data suggest that the sucrose non-fermenting 1-related kinases 2 (SnRK2s) are very important to abiotic stress for plants. In rice, these kinases are known as osmotic stress/ABA-activated protein kinases (SAPKs). Osmotic stress/ABA-activated protein kinase 3 (OsSAPK3) is a member of SnRK2II in rice, but its function is still unclear. RESULTS: The expression of OsSAPK3 was up regulated by drought, NaCl, PEG and ABA. OsSAPK3 mutated seedings (sapk3-1 and sapk3-2) showed reduced hypersensitivity to exogenous ABA...
January 24, 2023: BMC Plant Biology
https://read.qxmd.com/read/36661107/the-protective-effect-of-zinc-selenium-and-chromium-on-myocardial-fibrosis-in-the-offspring-of-rats-with-gestational-diabetes-mellitus
#22
JOURNAL ARTICLE
Haichao Deng, Xueqiong Yao, Ningning Cui, Shanshan Huang, Yanyan Ge, Rui Liu, Xuefeng Yang
The offspring of gestational diabetes mellitus (GDM) mothers are considered to be at the risk of cardiovascular diseases due to intrauterine hyperglycemia exposure. Our previous study showed that zinc, selenium, and chromium dramatically alleviated glucose intolerance in GDM rats and their offspring ( P < 0.05). However, the effects of these elements on the damage of the cardiac myocytes of GDM offspring and the underlying mechanisms have not been demonstrated. Here, we investigated the beneficial effects of zinc (10 mg per kg bw), selenium (20 μg per kg bw), and chromium (20 μg per kg bw) supplementation on myocardial fibrosis in the offspring of GDM rats induced by a high-fat and sucrose (HFS) diet...
January 20, 2023: Food & Function
https://read.qxmd.com/read/36615754/glycine-supplementation-in-obesity-worsens-glucose-intolerance-through-enhanced-liver-gluconeogenesis
#23
JOURNAL ARTICLE
Anaïs Alves, Frédéric Lamarche, Rémy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stéphanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, Gilles J P Rautureau, Baptiste Panthu, Béatrice Morio
Interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which contributes to disruption of the insulin signaling pathway. In addition, the plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Certain nutrients have been shown to regulate MAMs; therefore, we tested whether glycine supplementation could reduce insulin resistance in the liver by promoting MAM integrity. Glycine (5 mM) supported MAM integrity and insulin response in primary rat hepatocytes cultured under control and lipotoxic (palmitate 500 µM) conditions for 18 h...
December 24, 2022: Nutrients
https://read.qxmd.com/read/36602239/the-preventive-effect-of-mussel-oil-on-gestational-diabetes-mellitus-in-pregnant-mice-fed-by-a-high-fat-and-high-sucrose-diet
#24
JOURNAL ARTICLE
Kelei Li, Huiying Li, Xiaolei Song, Xiaotong Kuang, Shiyi Liu, Suqing Zhu, Duo Li
The present study aimed to investigate the preventive effect of mussel oil (MO) on gestational diabetes mellitus (GDM) in mice fed by a high-fat and high-sucrose (HFHS) diet. Pregnant mice were allocated to four groups: normal diet + corn oil (CO), HFHS + CO, HFHS + fish oil (FO), and HFHS + MO. The total n-3 polyunsaturated fatty acids (PUFAs) in MO (51.30%) and FO (48.25%) were comparable (mainly C22:6n-3 and C20:5n-3). HFHS + MO and HHFS + FO had a significantly lower area under the curve (AUC) for the oral glucose tolerance test (OGTT) than the HFHS + CO group...
January 5, 2023: Food & Function
https://read.qxmd.com/read/36404813/metformin-inhibits-cardiometabolic-syndrome-associated-cognitive-deficits-in-high-fat-diet-rats
#25
JOURNAL ARTICLE
Hanish Singh Jayasingh Chellammal, Mizaton Hazizul Hasan, Rahul P Kshirsagar, Vamshi Krishna Reddy Musukula, Dhani Ramachandran, Prakash V Diwan
OBJECTIVES: Glucose intolerance and insulin resistance are hallmarks of metabolic syndrome and lead to Alzheimer's disease (AD). The purpose of this study is to elucidate the neuroprotective effect of metformin through insulin regulation with cardiometabolic and neurotransmitter metabolic enzyme regulation in high-fat, high-sucrose diet and streptozotocin (HFHS-STZ)-induced rats. METHODS: Male Wistar rats were treated with metformin (180 mg/kg and 360 mg/kg)...
December 2022: Journal of Diabetes and Metabolic Disorders
https://read.qxmd.com/read/36384942/chronic-enteropathy-associated-with-slco2a1-gene-and-hereditary-fructose-intolerance-a-coincidence-of-two-rare-diseases
#26
Utku Dönger, Khaled Warasnhe, Figen Özçay, Zehra Şule Haskoloğlu, Halil İbrahim Aydın, Serdar Ceylaner
Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare disorder characterized by multiple small intestine ulcers. Patients with CEAS typically present with chronic anemia and gastrointestinal bleeding. Besides CEAS, SLCO2A1 mutations cause primary hypertrophic osteoarthropathy (PHO) which is considered as an extraintestinal manifestation in CEAS patients. Since CEAS and Crohn's disease are clinically indistinguishable, patients are often misdiagnosed with Crohn's disease. Herein, we describe a 4-year-old Turkish girl with CEAS due to homozygous pathogenic variant (c...
November 13, 2022: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://read.qxmd.com/read/36382966/endothelial-extracellular-signal-regulated-kinase-thromboxane-a2-prostanoid-receptor-pathway-aggravates-endothelial-dysfunction-and-insulin-resistance-in-a-mouse-model-of-metabolic-syndrome
#27
JOURNAL ARTICLE
Atsushi Sato, Yusuke Yumita, Kazuki Kagami, Yuki Ishinoda, Toyokazu Kimura, Ayumu Osaki, Takumi Toya, Takayuki Namba, Shogo Endo, Yasuo Ido, Yuji Nagatomo, Yasushi Satoh, Takeshi Adachi
Background Metabolic syndrome is characterized by insulin resistance, which impairs intracellular signaling pathways and endothelial NO bioactivity, leading to cardiovascular complications. Extracellular signal-regulated kinase (ERK) is a major component of insulin signaling cascades that can be activated by many vasoactive peptides, hormones, and cytokines that are elevated in metabolic syndrome. The aim of this study was to clarify the role of endothelial ERK2 in vivo on NO bioactivity and insulin resistance in a mouse model of metabolic syndrome...
November 16, 2022: Journal of the American Heart Association
https://read.qxmd.com/read/36359243/long-term-memory-function-impairments-following-sucrose-exposure-in-juvenile-versus-adult-rats
#28
JOURNAL ARTICLE
Héctor Coirini, Mariana Rey, María Claudia Gonzalez Deniselle, María Sol Kruse
We previously described that excessive consumption of sucrose during youth produces fear memory and anxiety-like behavior in adulthood. Here, we evaluated whether high cognitive function is also affected by studying early sucrose consumption in object recognition memory (NOR). Male Sprague Dawley rats were tested for short-term, long-term, and consolidated NOR after 25 days of unlimited sucrose access in juvenile (PD 25-50) or adult age (PD 75-100). All rats spent equal time exploring the two objects during the sample phase T1...
October 27, 2022: Biomedicines
https://read.qxmd.com/read/36304608/sucrose-intolerance-in-adults-with-common-functional-gastrointestinal-symptoms
#29
JOURNAL ARTICLE
Christine L Frissora, Satish S C Rao
Sucrose intolerance is a form of carbohydrate malabsorption caused by sucrase-isomaltase deficiency that is more common than recognized. Its symptoms include postprandial cramping, bloating, gas, and diarrhea, which are difficult to distinguish from irritable bowel syndrome. The gold standard test for diagnosing sucrase deficiency is a sucrase enzyme assay of duodenal biopsies obtained by endoscopy. Hydrogen-methane or 13 C-sucrose breath tests are noninvasive methods to screen for sucrose malabsorption. This chart review included 258 consecutive adults (47 men and 211 women) with chronic unexplained gastrointestinal symptoms and suspected sucrose intolerance who were screened with a hydrogen-methane or 13 C-sucrose breath test...
2022: Proceedings of the Baylor University Medical Center
https://read.qxmd.com/read/36297523/the-novel-peptide-chm-273s-has-therapeutic-potential-for-metabolic-disorders-evidence-from-in-vitro-studies-and-high-sucrose-diet-and-high-fat-diet-rodent-models
#30
JOURNAL ARTICLE
Nikita A Mitkin, Vsevolod V Pavshintcev, Iuliia A Sukhanova, Igor I Doronin, Gennady A Babkin, Marianna Sadagurski, Anton V Malyshev
The aim of this study was to develop a novel peptide potentially applicable for the treatment of metabolic conditions, such as obesity and type 2 diabetes (T2D). We identified CHM-273S from the list of peptides from milk hydrolysate obtained by HPLC/MS-MS. In vitro analysis of primary murine fibroblasts indicated the potential of CHM-273S to upregulate IRS2 mRNA expression. CHM-273S showed a prominent anorexigenic effect in mice with the induction of a key mechanism of leptin signaling via STAT3 in the hypothalamus as a possible effector...
September 30, 2022: Pharmaceutics
https://read.qxmd.com/read/36245490/quercetin-supplementation-alters-adipose-tissue-and-hepatic-transcriptomes-and-ameliorates-adiposity-dyslipidemia-and-glucose-intolerance-in-adult-male-rats
#31
JOURNAL ARTICLE
Adéla Kábelová, Hana Malínská, Irena Marková, Martina Hűttl, Blanka Chylíková, Ondřej Šeda
Quercetin, a flavonoid present in many fruits and vegetables, exhibits beneficial effects toward abnormalities related to metabolic syndrome. In this study, to further investigate metabolic and transcriptomic responses to quercetin supplementation, we used a genetic model of metabolic syndrome. Adult male rats of the PD/Cub strain were fed either a high-sucrose diet (HSD; control PD rats) or HSD fortified with quercetin (10 g quercetin/kg diet; PD-Q rats). Morphometric and metabolic parameters, along with transcriptomic profiles of the liver and retroperitoneal fat, were assessed...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/36202025/western-diet-induced-mouse-model-of-non-alcoholic-fatty-liver-disease-associated-with-metabolic-outcomes-features-of-gut-microbiome-liver-adipose-tissue-axis
#32
JOURNAL ARTICLE
Guilherme R Romualdo, Letícia Cardoso Valente, Ana Carolina Sprocatti, Gabriel Prata Bacil, Isadora Penedo de Souza, Josias Rodrigues, Maria Aparecida Marchesan Rodrigues, Mathieu Vinken, Bruno Cogliati, Luís Fernando Barbisan
OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) has a growing epidemiologic and economic burden. It is associated with Western diet (WD) patterns, and its pathogenesis involves metabolic disorders (obesity, dyslipidemia, hyperglycemia, and diabetes) and gut dysbiosis, features that are usually neglected or not reproduced by most animal models. Thus, we established a 6-mo WD-induced NAFLD mouse model associated with metabolic disorder, investigating its main features at the gut microbiome-liver-adipose tissue axis, also evaluating the correlations of gut dysbiosis to the other disease outcomes...
2022: Nutrition
https://read.qxmd.com/read/36079714/probiotication-of-nutritious-fruit-and-vegetable-juices-an-alternative-to-dairy-based-probiotic-functional-products
#33
REVIEW
Floyd Darren Mojikon, Melisa Elsie Kasimin, Arnold Marshall Molujin, Jualang Azlan Gansau, Roslina Jawan
Fruits and vegetables are widely known to be rich in nutrients, antioxidants, vitamins, dietary fiber, minerals, and a bioactive molecule, making them an essential component of a balanced diet with multiple documented positive effects on human health. The probiotication of plant-based juices for the production of functional and nutraceutical food serves as a healthy alternative to dairy probiotics. They are cholesterol free, lack several dairy allergens, and also encourage ingestion for people with lactose intolerance...
August 23, 2022: Nutrients
https://read.qxmd.com/read/36060961/distinct-impacts-of-fat-and-fructose-on-the-liver-muscle-and-adipose-tissue-metabolome-an-integrated-view
#34
JOURNAL ARTICLE
Maria João Meneses, Inês Sousa-Lima, Ivana Jarak, João F Raposo, Marco G Alves, Maria Paula Macedo
OBJECTIVE: In the last years, changes in dietary habits have contributed to the increasing prevalence of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). The differential burden of lipids and fructose on distinct organs needs to be unveiled. Herein, we hypothesized that high-fat and high-fructose diets differentially affect the metabolome of insulin-sensitive organs such as the liver, muscle, and different adipose tissue depots...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/36052111/hereditary-fructose-intolerance-a-comprehensive-review
#35
REVIEW
Sumit Kumar Singh, Moinak Sen Sarma
Hereditary fructose intolerance (HFI) is a rare autosomal recessive inherited disorder that occurs due to the mutation of enzyme aldolase B located on chromosome 9q22.3. A fructose load leads to the rapid accumulation of fructose 1-phosphate and manifests with its downstream effects. Most commonly children are affected with gastrointestinal symptoms, feeding issues, aversion to sweets and hypoglycemia. Liver manifestations include an asymptomatic increase of transaminases, steatohepatitis and rarely liver failure...
July 9, 2022: World Journal of Clinical Pediatrics
https://read.qxmd.com/read/36028097/transgenerational-effects-of-zinc-selenium-and-chromium-supplementation-on-glucose-homeostasis-in-female-offspring-of-gestational-diabetes-rats
#36
JOURNAL ARTICLE
Xueqiong Yao, Shanshan Huang, Yan Li, Yanyan Ge, Zhen Zhang, Jie Ning, Xuefeng Yang
Clinical studies have demonstrated that maternal gestational diabetes mellitus (GDM) increases the offspring's risk of developing glucose intolerance. Our previous study reported that co-supplementation with zinc, selenium, and chromium improved insulin resistance in diet-induced GDM rats. Here, Transgenerational effects of supplementation with zinc (10 mg/kg.bw), selenium (20 μg/kg.bw), and chromium (20 μg/kg.bw) in F1 female offspring of both zinc, selenium and chromium (ZnSeCr)-treated, and untreated GDM rats daily by gavage from weaning to the postpartum were investigated in the present study...
December 2022: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/35933635/impact-of-dietary-sucralose-and-sucrose-sweetened-water-intake-on-lipid-and-glucose-metabolism-in-male-mice
#37
JOURNAL ARTICLE
Xinyi Wu, Le Cui, Haoquan Wang, Jinhong Xu, Zhaozhao Zhong, Xibei Jia, Jiaqi Wang, Huahua Zhang, Yanteng Shi, Yuhang Tang, Qianhui Yang, Qiongdan Liang, Yujing Zhang, Jing Li, Xiaohong Jiang
AIMS: Overconsumption of sugar-sweetened beverages (SSBs) is associated with an increased risk of metabolic disorders, including obesity and diabetes. However, accumulating evidence also suggests the potential negative impact of consuming nonnutritive sweeteners (NNSs) on weight and glycaemic control. The metabolic effects of sucralose, the most widely used NNS, remain controversial. This study aimed to compare the impact of intake of dietary sucralose (acceptable daily intake dose, ADI dose) and sucrose-sweetened water (at the same sweetness level) on lipid and glucose metabolism in male mice...
August 7, 2022: European Journal of Nutrition
https://read.qxmd.com/read/35930123/ironing-it-all-out-a-comprehensive-review-of-iron-deficiency-anemia-in-inflammatory-bowel-disease-patients
#38
REVIEW
Laura A Maas, Mahesh Krishna, Alyssa M Parian
Iron deficiency anemia affects approximately 45% of patients with inflammatory bowel disease (IBD), negatively impacts the quality of life in this patient population, and significantly burdens our healthcare system. The pathogenesis of iron deficiency in IBD patients is multifactorial, including intestinal bleeding, malabsorption, and inadequate oral intake. Regular screening and diagnosis in these patients are imperative, and often patients have mixed iron deficiency anemia and anemia of chronic disease, especially in those with active inflammation...
August 5, 2022: Digestive Diseases and Sciences
https://read.qxmd.com/read/35912025/sucrose-alleviates-capsaicin-induced-tongue-burning-an-in-vivo-study
#39
JOURNAL ARTICLE
Duangchewan Puengsurin, Rittinarong Meepong, Nattapon Rotpenpian, Aree Wanasuntronwong, Rudee Surarit
Background: Spicy foods are flavorful and stimulate salivation, which is beneficial for individuals with poor appetite. They are also ubiquitous in many regional cuisines, but the chemical compounds in such foods, especially capsaicin from chili peppers, can cause tissue inflammation and generate intolerable burning pain in the oral cavity. Material and Methods: To identify a potential method to reduce capsaicin-induced burning pain without influencing food flavor, we tested the effects of mouth rinsing with various concentrations of sucrose...
July 2022: Journal of Clinical and Experimental Dentistry
https://read.qxmd.com/read/35854131/vitamin-c-and-folate-status-in-hereditary-fructose-intolerance
#40
JOURNAL ARTICLE
Ainara Cano, Carlos Alcalde, Amaya Belanger-Quintana, Elvira Cañedo-Villarroya, Leticia Ceberio, Silvia Chumillas-Calzada, Patricia Correcher, María Luz Couce, Dolores García-Arenas, Igor Gómez, Tomás Hernández, Elsa Izquierdo-García, Dámaris Martínez Chicano, Montserrat Morales, Consuelo Pedrón-Giner, Estrella Petrina Jáuregui, Luis Peña-Quintana, Paula Sánchez-Pintos, Juliana Serrano-Nieto, María Unceta Suarez, Isidro Vitoria Miñana, Javier de Las Heras
BACKGROUND: Hereditary fructose intolerance (HFI) is a rare inborn error of fructose metabolism caused by the deficiency of aldolase B. Since treatment consists of a fructose-, sucrose- and sorbitol-restrictive diet for life, patients are at risk of presenting vitamin deficiencies. Although there is no published data on the status of these vitamins in HFI patients, supplementation with vitamin C and folic acid is common. Therefore, the aim of this study was to assess vitamin C and folate status and supplementation practices in a nationwide cohort of HFI patients...
July 19, 2022: European Journal of Clinical Nutrition
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