Read by QxMD icon Read

Sucrose intolerance

Mariana Gomez-Smith, Sudhir Karthikeyan, Matthew S Jeffers, Rafal Janik, Lynsie A Thomason, Bojana Stefanovic, Dale Corbett
Many promising findings from pre-clinical research have failed to translate to the clinic due to their inability to incorporate human disease co-morbidity. A variety of rodent diets and feeding durations are currently used in models of human metabolic syndrome, obesity and diabetes. One model, the Cafeteria (CAF) diet, makes use of grocery store-purchased food items that more closely approximate the human ultra-processed diet than commercial high-fat or high-sugar rodent diets. The present study describes the development of metabolic syndrome in rats fed a CAF diet as well as the recovery of metabolic syndrome following a healthy "lifestyle" change...
October 2, 2016: Physiology & Behavior
Antone R Opekun, Albert M Balesh, Harold T Shelby
Sucrase insufficiency has been observed in children with of functional bowel disorders (FBD) and symptoms of dietary carbohydrate intolerance may be indistinguishable from those of FBD. A two-phase (13)C-sucrose/(13)C-glucose breath test ((13)C-S/GBT) was used to assess sucrase activity because disaccharidase assays are seldom performed in adults. When (13)C-sucrose is hydrolyzed to liberate monosaccharides, oxidation to (13)CO2 is a proportional indicator of sucrase activity. Subsequently, (13)C-glucose oxidation rate was determined after a secondary substrate ingestion (superdose) to adjust for individual habitus effects (Phase II)...
2016: BioMed Research International
J K Parkman, X Mao, K Dillon, A Gudivada, N Moustaid-Moussa, A M Saxton, J H Kim
Background: The co-epidemic of obesity and type 2 diabetes is associated with increased morbidity and mortality. Genetic factors are highly involved in the development of these diseases, in the form of interactions of multiple genes within obesogenic and diabetogenic environments, such as a high fat diet. The TALLYHO/Jng (TH) mouse is an inbred polygenic model for human obesity and type 2 diabetes. In order to further develop the TH mouse as a clinically relevant model, we investigated diet dependence of obesity and type 2 diabetes in TH mice vs...
July 20, 2016: Experimental and Clinical Endocrinology & Diabetes
Avila-Nava Azalia, Noriega Lg, Tovar Ar, Granados O, Perez-Cruz C, Pedraza-Chaverri José, Torres Nimbe
SCOPE: There is few information about the possible health effects of a food combination based on a prehispanic Mexican diet (PMD). This diet rich in fiber, polyphenols, a healthy ratio of omega 6/omega 3 fatty acids, and vegetable protein could improve carbohydrate and lipid metabolism, gut microbiota and cognitive function. METHODS AND RESULTS: We examined the effect of a PMD in a sucrose enriched high-fat model. The PMD contains corn, beans, tomato, nopal, chia and pumpkin seeds in dehydrated form...
June 29, 2016: Molecular Nutrition & Food Research
Flavia Fernandes-Lima, Thiago Luís Ribeiro Gomes Monte, Fernanda Amorim de Morais Nascimento, Bianca Martins Gregório
High-sucrose and high-fat diets induce deregulation in the metabolism of lipids and carbohydrates. This study aimed to detect the initial consequences on lipogenesis, gluconeogenesis and insulin signaling in the livers of rodents fed high-fat and/or high-sucrose diets for a short period of time. Male mice received a standard chow (SC), high-fat (HF), high-sucrose (HSu) or high-fat, high-sucrose (HFHSu) diet for 4 weeks. At euthanasia, blood was collected and the liver was removed for histomorphometrical and molecular analysis...
June 17, 2016: Cells, Tissues, Organs
Kazumasa Horikawa, Chiaki Hashimoto, Yosuke Kikuchi, Miki Makita, Shin-Ichi Fukudome, Kimiko Okita, Naoyuki Wada, Katsutaka Oishi
Epidemiological studies have shown that the consumption of whole grains can reduce risk for metabolic disorders. We recently showed that chronic supplementation with wheat alkylresorcinols (ARs) prevents glucose intolerance and insulin resistance with hepatic lipid accumulation induced in mice by a high-fat high-sucrose diet (HFHSD). This study examines the effects of ARs on the micellar solubility of cholesterol in vitro, as well as the effects of transient AR supplementation on faecal lipid excretion and plasma lipid levels in mice...
June 16, 2016: Natural Product Research
Greg M Kowalski, Steven Hamley, Ahrathy Selathurai, Joachim Kloehn, David P De Souza, Sean O'Callaghan, Brunda Nijagal, Dedreia L Tull, Malcolm J McConville, Clinton R Bruce
In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway fluxes that occur under these conditions. Using a combination of stable isotope, and targeted metabolomic approaches we investigated the acute (7-9 days) hepatic effects of switching high-fat high-sucrose diet (HFD) fed obese mice back to a chow diet. Upon the switch, energy intake was reduced, resulting in reductions of fat mass and hepatic triacyl- and diacylglycerol...
2016: Scientific Reports
Jennifer L Kuk, Ruth E Brown
This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey. Aspartame intake significantly influenced the association between body mass index (BMI) and glucose tolerance (interaction: P = 0.004), wherein only those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance than those reporting no aspartame intake. Therefore, consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance...
July 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Martha L Louzada, Cyrus C Hsia, Fatimah Al-Ani, Fiona Ralley, Anargyros Xenocostas, Janet Martin, Sarah E Connelly, Ian H Chin-Yee, Leonard Minuk, Alejandro Lazo-Langner
BACKGROUND: Intravenous iron therapy is a treatment option for iron deficient patients who are intolerant to oral iron or where oral iron is ineffective, but with possible adverse effects. Currently, prospective studies comparing different intravenous iron formulations are needed to determine safety and efficacy of these agents. METHODS: We conducted a prospective, double-blind, randomized controlled trial (RCT) to assess the feasibility of a trial comparing the safety of high molecular weight intravenous iron dextran, Infufer®, with intravenous iron sucrose, Venofer®, in non-hemodialysis adult outpatients...
2016: BMC Hematology
Hong Xu, Yang Zhou, Yongxia Liu, Jian Ping, Qiyang Shou, Fangming Chen, Ru Ruo
Nonalcoholic fatty liver disease and cirrhosis are strongly associated with insulin resistance and glucose intolerance. To date, the influence of metformin on glycogen synthesis in the liver is controversial. Limited studies have evaluated the effect of metformin on hepatic insulin signaling pathway in vivo In this study, an insulin-resistant rat model of nonalcoholic steatohepatitis and cirrhosis was developed by high-fat and high-sucrose diet feeding in combination with subcutaneous injection of carbon tetrachloride...
May 2016: Journal of Endocrinology
Serpil Sahin, Haluk Hamamci, Sultan Garayev
People suffering from lactose intolerance cannot digest milk or lactose-containing foods. Lactose-free diet is essential for them since they do not have the ability to produce lactase to breakdown milk sugar. Physical properties of lactose-free dairy desserts will most probably be different than that of lactose containing ones because of lactose hydrolysis. In this study, it was aimed to analyze the rheological and textural behaviors of different lactose-free dessert formulations containing different gum types and different waxy maize starch and sucrose concentrations...
February 27, 2016: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
Yu Yasutake, Akiko Mizokami, Tomoyo Kawakubo-Yasukochi, Sakura Chishaki, Ichiro Takahashi, Hiroshi Takeuchi, Masato Hirata
Uncarboxylated osteocalcin (GluOC), a bone-derived hormone, regulates energy metabolism by stimulating insulin secretion, pancreatic β-cell proliferation, and adiponectin expression in adipocytes. We previously showed that long-term intermittent or daily oral administration of GluOC reduced the fasting blood glucose level, improved glucose tolerance, and increased the fasting serum insulin concentration as well as pancreatic β-cell area in female mice fed a normal or high-fat, high-sucrose diet. We have now performed similar experiments with male mice and found that such GluOC administration induced glucose intolerance, insulin resistance, and adipocyte hypertrophy in those fed a high-fat, high-sucrose diet...
February 16, 2016: American Journal of Physiology. Endocrinology and Metabolism
Angélica Heringer Rodrigues, Carolina Campos Lima Moreira, Érica Guilhen Mario, Letícia Maria de Souza Cordeiro, Gleide Fernandes Avelar, Leida Maria Botion, Valéria Ernestânia Chaves
Several studies have demonstrated that a high-fructose (FRUC) diet induces metabolic and haemodynamic abnormalities, known as the metabolic syndrome, which are characterised by obesity, glucose intolerance, insulin resistance, dyslipidaemia and hypertension. In this study, the effect of a FRUC diet (60 % fructose) for 8 weeks on the metabolism of lipids in liver and epididymal adipose tissue from Wistar rats was compared with the AIN-93M diet and the effects of the AIN-93M diet were compared with a chow diet...
August 2016: Endocrine
João G B Leandro, Jair M Espindola-Netto, Maria Carolina F Vianna, Lilian S Gomez, Thaina M DeMaria, Monica M Marinho-Carvalho, Patricia Zancan, Heitor A Paula Neto, Mauro Sola-Penna
Overweight and obesity have become epidemic worldwide and are linked to sedentary lifestyle and the consumption of processed foods and drinks. Citrate is a metabolite that plays central roles in carbohydrate and lipid metabolism. In addition, citrate is the additive most commonly used by the food industry, and therefore is highly consumed. Extracellular citrate can freely enter the cells via the constitutively expressed plasma membrane citrate transporter. Within the cytosol, citrate is readily metabolised by ATP-citrate lyase into acetyl-CoA - the metabolic precursor of endogenously produced lipids and cholesterol...
March 28, 2016: British Journal of Nutrition
Florence Tsofack Ngueguim, Eloi Christian Esse, Paul Désiré Djomeni Dzeufiet, Raceline Kamkumo Gounoue, Danielle Claude Bilanda, Pierre Kamtchouing, Théophile Dimo
BACKGROUND: Consumption of foods rich in carbohydrates and fats, result in an increase in obesity and consequently type 2 diabetes. The present study was carried out to evaluate the effects of oxidised palm oil and sucrose (SOPO +S) on some metabolic parameters and to investigate the effects of aqueous extract from barks of Sclerocarrya birrea on SOPO + S induced damages. METHODS: During 16 weeks, animals received every day a supplement of oxidised palm oil (10 %) and 10 % sucrose as drinking water)...
2016: BMC Complementary and Alternative Medicine
Arij Harzallah, Mohamed Hammami, Malgorzata A Kępczyńska, David C Hislop, Jonathan R S Arch, Michael A Cawthorne, Mohamed S Zaibi
OBJECTIVE: The potentially beneficial effects of pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on adiposity, lipid profile, glucose homoeostasis, as well as on the underlying inflammatory mechanisms, were examined in high-fat and high-sucrose (HF/HS) diet-induced obese (DIO) mice. MEASUREMENTS: Body weight, body fat, energy expenditure, food and liquid intake, blood glucose, and plasma levels of insulin, lipids and cytokines were measured...
2016: Archives of Physiology and Biochemistry
Mohammad Aslam, Sarla Aggarwal, Krishna Kumar Sharma, Vikas Galav, Sri Venkata Madhu
Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) have been found to be associated with postprandial hypertriglyceridemia (PPHTg). However, whether PPHTg can cause IR and diabetes is not clear. We therefore investigated the role of PPHTg in development of T2DM in rat model of T2DM. 96 male Wistar rats were randomized into four groups (24 rats each). Control Group A, high sucrose diet (HSD) Group B, HSD+Pioglitazone (10 mg/kg/day) Group C and HSD+Atorvastatin (20 mg/kg/day) Group D. Fat and glucose tolerance tests were done at regular intervals in all groups besides insulin and body weight measurement...
2016: PloS One
Jayanthi Maniam, Christopher P Antoniadis, Margaret J Morris
Early-life stress affects metabolic outcomes and choice of diet influences the development of metabolic disease. Here we tested the hypothesis that chronic sugar intake exacerbates metabolic deficits induced by early-life stress. Early-life stress was induced in Sprague-Dawley rats using limited nesting material in early lactation (LN, postnatal days 2-9), and siblings were given chow alone or with additional sucrose post weaning (n = 9-17 per group). Female control and LN siblings had unlimited access to either chow plus water, or chow and water plus 25% sucrose solution (Sucrose), from 3-15 weeks of age...
2015: Stress: the International Journal on the Biology of Stress
Sarine Sebastian Karot, Vasantharaju Gowdra Surenahalli, Anoop Kishore, Jayesh Mudgal, Krishnadas Nandakumar, Magith Thambi Chirayil, Geetha Mathew, Gopalan Kutty Nampurath
BACKGROUND: The replacement of the thiazolidinedione moiety with a thiazolidinone may yield antidiabetic compounds with similar pleiotropic effects. Hence, the aim of the present study was to explore the dose-related antihyperglycemic and hypolipidemic effects of two synthesized novel thiazolidin-4-one derivatives, one with a nicotinamide and the other with a p-chlorophenoxyacetamide substitution at the N3 position of the thiazolidinone ring (NAT1 and PAT1, respectively), in a rodent model of metabolic syndrome (MetS)...
September 2016: Journal of Diabetes
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intracellular NAD+ levels are tightly regulated and often respond rapidly to nutritional and environmental changes. Numerous studies indicate that elevating NAD+ may be therapeutically beneficial in the context of numerous diseases. However, the role of NAD+ on skeletal muscle exercise performance is poorly understood...
2015: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"