keyword
MENU ▼
Read by QxMD icon Read
search

wet-amd

keyword
https://www.readbyqxmd.com/read/28152206/nursing-actions-that-create-a-sense-of-good-nursing-care-in-patients-with-wet-age-related-macular-degeneration
#1
Åsa Emsfors, Lennart Christensson, Carina Elgán
BACKGROUND: People who suffer from wet age-related macular degeneration (AMD) risk central vision loss. Treatment with anti-VEGF is the only available option at present that preserves vision and no definitive cure currently exists. Patients feel that they are compelled to accept this treatment because they might otherwise become blind. AIM: To identify and describe nursing actions performed by nurses that create a sense of good nursing care in patients with wet (AMD)...
February 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28046346/su-g-tep3-05-in-vitro-demonstration-of-endothelial-dose-enhancement-due-to-gold-nanoparticles-during-low-voltage-radiotherapy
#2
S Yasmin-Karim, M Moreau, R Kumar, G M Makrigiorgos, J Hanlon, M Arnoldussen, J Hempstead, J Celli, W Ngwa
PURPOSE: Oraya Therapy uses low-voltage, stereotactic, highly targeted X-rays for the treatment of wet age-related macular degeneration (AMD) - offering a new option for patients worldwide. Neovascular endothelial cells play a crucial role in the pathogenesis of this disease. This in-vitro study investigates the potential of gold nanoparticles (GNP) to enhance endothelial cell damage during low-voltage radiotherapy towards potential applications in the treatment of wet-AMD. METHODS: Primary human umbilical cord vein endothelium cells (HUVEC) were treated with 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28008222/evaluation-of-peripheral-fundus-autofluorescence-in-eyes-with-wet-age-related-macular-degeneration
#3
Tetsuyuki Suetsugu, Aki Kato, Munenori Yoshida, Tsutomu Yasukawa, Akiko Nishiwaki, Norio Hasegawa, Hideaki Usui, Yuichiro Ogura
PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28005632/association-between-the-vitreomacular-interface-and-optical-coherence-tomography-characteristics-in-wet-age-related-macular-degeneration
#4
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
PURPOSE: To study the effect of the vitreomacular interface on various wet age-related macular degeneration (AMD) characteristics including the size and type of choroidal neovascularization (CNV), choroidal thickness, and activity of the CNV. METHODS: This was a retrospective observational cross-sectional study. The study included 43 patients (51 eyes) with treatment-naive age-related macular degeneration. Twenty-six patients with wet AMD in one eye and dry AMD in the other eye were included in a paired-eye analysis...
December 21, 2016: Retina
https://www.readbyqxmd.com/read/28003780/aflibercept-in-refractory-wet-amd-treated-with-ranibizumab-anatomical-and-visual-outcome
#5
Sleiman Abou-Ltaif
PURPOSE: To assess the anatomical outcome of patients with exudative age-related macular degeneration resistant to ranibizumab treated with aflibercept. METHOD: Prospective, interventional, case series, where we treated a group of patients deemed resistant to Ranibizumab after 6 months of persistence of intra- or subretinal fluid despite continuous treatment. RESULTS: The study included 17 patients, 3 males and 14 females. The average males age was 85 (range 83-87), and that of females was 79...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28003009/hot-topics-in-dry-amd
#6
Raja Narayanan, Baruch D Kuppermann
: substantial progress in the development of new therapies for wet AMD using inhibition of vascular endothelial growth factor (VEGF), the severe visual impairment associated with geographic atrophy in dry AMD remains untreatable. A number of therapeutic options for dry AMD are being developed and are in various stages of clinical trials. METHODS: Review of literature. RESULTS: Enhancers of choroidal blood flow, neuroprotectants and anti-complement factors are the key targets in the research for the treatment of dry AMD...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28003006/hot-topics-in-dry-amd
#7
Raja Narayanan, Baruch D Kuppermann
: substantial progress in the development of new therapies for wet AMD using inhibition of vascular endothelial growth factor (VEGF), the severe visual impairment associated with geographic atrophy in dry AMD remains untreatable. A number of therapeutic options for dry AMD are being developed and are in various stages of clinical trials. METHODS: Review of literature. RESULTS: Enhancers of choroidal blood flow, neuroprotectants and anti-complement factors are the key targets in the research for the treatment of dry AMD...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27966830/homocysteine-and-risk-of-age-related-macular-degeneration-a-systematic-review-and-meta-analysis
#8
REVIEW
Antonio Pinna, Francesco Zaccheddu, Francesco Boscia, Ciriaco Carru, Giuliana Solinas
There is still no agreement on total plasma homocysteine (tHcy) role in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries. We performed a systematic review and meta-analysis of the published data on the correlation between tHcy and AMD. MEDLINE/PubMed and ISI Web of Sciences searches were performed according to MOOSE guidelines. Case-control studies were eligible for inclusion. Participants and controls were AMD patients and subjects without AMD. The main outcome measure was wet AMD...
December 14, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27928444/the-remote-effects-of-intravitreal-anti-vegf-therapy
#9
Balta F, Merticariu M, Taban C, Neculau G, Merticariu A, Muresanu D, Badescu D, Jinga V
Objective: To study the effects of intravitreal anti-Vascular Endothelial Growth Factor (VEGF) therapy with Avastin for wet Age-Related Macular Degeneration (AMD) on Benign Prostatic Hyperplasia (BPH)-related symptoms. Methods: An exploratory trial was conducted from August 1, 2013 to February 1, 2014, that included 14 male patients previously diagnosed with BPH, who were aged between 59 and 69 years. The trial was performed in Bucharest and involved two medical institutions: the Clinical Hospital of Eye Emergencies and the "Prof...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27913556/how-does-age-related-macular-degeneration-affect-real-world-visual-ability-and-quality-of-life-a-systematic-review
#10
Deanna J Taylor, Angharad E Hobby, Alison M Binns, David P Crabb
OBJECTIVES: To review systematically the evidence of age-related macular degeneration (AMD) affecting real-world visual ability and quality of life (QoL). To explore trends in specific topics within this body of the literature. DESIGN: Systematic review. METHODS: A systematic literature search was carried out using MEDLINE, EMBASE, CINAHL, PsycINFO, PsychARTICLES and Health and Psychosocial Instruments for articles published up to January 2015 for studies including people diagnosed with AMD, assessing real-world visual ability or QoL as an outcome...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27876140/retinal-pigment-epithelium-cell-derived-exosomes-possible-relevance-to-cnv-in-wet-age-related-macular-degeneration
#11
Yao Tong, Ya-Li Zhou, Yi-Xiao Wang, Pei-Quan Zhao, Zhao-Yang Wang
Exosomes are small vesicles that are released by almost every cell type and play a crucial role in many physiological and pathological processes associated with different diseases. Specifically, they promote angiogenesis in the pathogenesis of some diseases. According to previous research, the proteins of exosomes taken from the aqueous humor (AH) of patients with wet-age related macular degeneration (AMD) may function as a new diagnostic biomarker of AMD, suggesting that exosomes may play an important role in the occurrence and development of choroidal neovascularization (CNV)...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27830057/automated-analysis-of-retinal-imaging-using-machine-learning%C3%A2-techniques-for-computer-vision
#12
Jeffrey De Fauw, Pearse Keane, Nenad Tomasev, Daniel Visentin, George van den Driessche, Mike Johnson, Cian O Hughes, Carlton Chu, Joseph Ledsam, Trevor Back, Tunde Peto, Geraint Rees, Hugh Montgomery, Rosalind Raine, Olaf Ronneberger, Julien Cornebise
There are almost two million people in the United Kingdom living with sight loss, including around 360,000 people who are registered as blind or partially sighted. Sight threatening diseases, such as diabetic retinopathy and age related macular degeneration have contributed to the 40% increase in outpatient attendances in the last decade but are amenable to early detection and monitoring. With early and appropriate intervention, blindness may be prevented in many cases. Ophthalmic imaging provides a way to diagnose and objectively assess the progression of a number of pathologies including neovascular ("wet") age-related macular degeneration (wet AMD) and diabetic retinopathy...
2016: F1000Research
https://www.readbyqxmd.com/read/27810558/single-ocular-injection-of-a-sustained-release-anti-vegf-delivers-6months-pharmacokinetics-and-efficacy-in-a-primate-laser-cnv-model
#13
Peter Adamson, Thomas Wilde, Eric Dobrzynski, Caroline Sychterz, Rodd Polsky, Edit Kurali, Richard Haworth, Chi-Man Tang, Justyna Korczynska, Fiona Cook, Irene Papanicolaou, Lemy Tsikna, Chris Roberts, Zoe Hughes-Thomas, James Walford, Daniel Gibson, John Warrack, Jos Smal, Ruud Verrijk, Paul E Miller, T Michael Nork, Jeffery Prusakiewicz, Timothy Streit, Steven Sorden, Craig Struble, Brian Christian, Ian R Catchpole
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing two different anti-VEGF domain antibodies (dAb) attached to a human IgG1 Fc region: a dual dAb. The delivery system is based on microparticles of PolyActive™ hydrogel co-polymer. The molecule was evaluated both in vitro for potency against VEGF and in ocular VEGF-driven efficacy models in vivo...
December 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27768118/clinical-features-and-long-term-progression-of-reticular-pseudodrusen-in-age-related-macular-degeneration-findings-from-a-multicenter-cohort
#14
J Q Gil, J P Marques, R Hogg, C Rosina, M L Cachulo, A Santos, G Staurenghi, U Chakravarthy, R Silva
PurposeTo determine whether reticular pseudodrusen (RPD) confer a long-term increased risk of progression to late age-related macular degeneration (AMD) in the fellow eye of patients with unilateral wet-AMD.Patients and methodsThis was a multicenter, combined prospective and retrospective, longitudinal, observational, study. Patients with wet-AMD in one eye were recruited from two centers and evaluated on the risk of progression to late-AMD in the second eye (study eye). A minimum follow-up of 5 years was required, unless progression occurred first...
October 21, 2016: Eye
https://www.readbyqxmd.com/read/27739558/comparing-ranibizumab-monotherapy-and-combination-with-single-photodynamic-therapy-in-wet-amd-retreatment-and-morphologic-results
#15
Katja Hatz, Ulrike Schneider, Bernhard Henrich, Beatrice Braun, Stefan Sacu, Christian Prünte
PURPOSE: To evaluate retreatment indications/morphologic responses to ranibizumab monotherapy and combination with verteporfin photodynamic therapy (PDT). METHODS: A total of 40 patients received 3 monthly intravitreal ranibizumab 0.3 mg injections combined with either PDT or sham PDT at baseline (1:1) followed by as-needed ranibizumab based on predetermined vision/anatomical criteria. RESULTS: Retreatment criteria were visual acuity (VA) loss (59%/58%), central retinal thickness (CRT) increase (27%/26%), or both (14%/16%)...
October 13, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27729757/the-efficacy-of-intravitreal-aflibercept-in-submacular-hemorrhage-secondary-to-wet-age-related-macular-degeneration
#16
Kyung-Hoon Shin, Tae Gon Lee, Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Dong Won Lee, Jung Il Han, Young Ju Lew, Han Joo Cho
PURPOSE: To evaluate the efficacy of intravitreal aflibercept monotherapy in submacular hemorrhage (SMH) secondary to wet age-related macular degeneration (AMD). METHODS: This study included 25 eyes in 25 patients with SMH involving the fovea secondary to wet-AMD. All patients were treated with three consecutive monthly intravitreal aflibercept (2.0 mg/0.05 mL) injections, followed by as-needed reinjection. They were followed for at least 6 months. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), and area of SMH were measured at diagnosis, as well as at 3 and 6 months after treatment initiation...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27725716/detection-of-aqueous-vegf-concentrations-before-and-after-intravitreal-injection-of-anti-vegf-antibody-using-low-volume-sampling-paper-based-elisa
#17
Min-Yen Hsu, Yu-Chien Hung, De-Kuang Hwang, Shang-Chi Lin, Keng-Hung Lin, Chun-Yuan Wang, Hin-Yeung Choi, Yu-Ping Wang, Chao-Min Cheng
Intraocular vascular endothelial growth factor (VEGF) levels play an important role in the pathogenesis of blindness-related diseases, such as age-related macular degeneration (AMD). Here, we aimed to develop a paper-based enzyme-linked immunosorbent assay (P-ELISA) to analyze the suppression of aqueous VEGF concentrations following intravitreal injection (IVI) of anti-VEGF antibody (bevacizumab or ranibizumab). A total of 25 eyes with wet AMD, one with myopic neovascularization, and one with polypoidal choroidal vasculopathy were enrolled in this study...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27711217/multi-functional-oct-enables-longitudinal-study-of-retinal-changes-in-a-vldlr-knockout-mouse-model
#18
Marco Augustin, Stanislava Fialová, Tanja Himmel, Martin Glösmann, Theresia Lengheimer, Danielle J Harper, Roberto Plasenzotti, Michael Pircher, Christoph K Hitzenberger, Bernhard Baumann
We present a multi-functional optical coherence tomography (OCT) imaging approach to study retinal changes in the very-low-density-lipoprotein-receptor (VLDLR) knockout mouse model with a threefold contrast. In the retinas of VLDLR knockout mice spontaneous retinal-chorodoidal neovascularizations form, having an appearance similar to choroidal and retinal neovascularizations (CNV and RNV) in neovascular age-related macular degeneration (AMD) or retinal angiomatous proliferation (RAP). For this longitudinal study, the mice were imaged every 4 to 6 weeks starting with an age of 4 weeks and following up to the age of 11 months...
2016: PloS One
https://www.readbyqxmd.com/read/27706724/clinical-study-of-the-correlation-between-complement-factor-h-polymorphism-and-age-related-macular-degeneration
#19
H T Dong, J X Zhang, Q M Li, F Z Li
This study aimed to investigate the correlation between age-related macular degeneration (AMD) of the liver-kidney yin-deficiency type and complement factor H (CFH) polymorphism, and to determine whether the C allele of the T1277C (Y402H) variant is a risk factor for this condition. We performed a case-control investigation of 60 patients with liver-kidney yin-deficiency AMD and 60 normal control subjects. Peripheral blood was collected from each participant for DNA extraction. Following amplification by polymerase chain reaction, the DNA samples were sequenced, and polymorphism of the CFH gene was examined...
September 16, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27693409/serum-paraoxonase-activity-in-relation-to-lipid-profile-in-age-related-macular-degeneration-patients
#20
Kannadasan AnandBabu, S R Bharathidevi, Sarangapani Sripriya, Parveen Sen, Vadivelu Jaya Prakash, Appukuttan Bindu, Natarajan Viswanathan, Narayanasamy Angayarkanni
Age-related Macular Degeneration (AMD) is a multifactorial disease causing visual impairment in old age. Oxidative stress is one of the main contributors for the disease progression. Paraoxonase (PON), a HDL-resident antioxidant enzyme which removes oxidized low density lipoprotein (oxLDL), which is not studied much in AMD. This study assesses the PON activities in relation to the lipid status and genetic variants in AMD patients. In this prospective case-control study, a total of 48 AMD patients and 30 unrelated healthy controls were recruited...
September 28, 2016: Experimental Eye Research
keyword
keyword
53816
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"