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https://www.readbyqxmd.com/read/29138543/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-after-intravitreal-ranibizumab-for-age-related-macular-degeneration
#1
Dimitrios Karagiannis, Irini Chatziralli, Konstantinos Kaprinis, Ilias Georgalas, Efstratios Parikakis, Panagiotis Mitropoulos
Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months' follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29132549/association-of-copy-number-variations-in-complement-factor-h-related-genes-among-age-related-macular-degenerative-subjects
#2
Norshakimah Md Bakri, Vasudevan Ramachandran, Hoo Fan Kee, Visvaraja Subrayan, Hazlita Isa, Nor Fariza Ngah, Nur Afiqah Mohamad, Ching Siew Mooi, Chan Yoke Mun, Patimah Ismail, Fazliana Ismail, Erma Suryana Sukiman, Wan Alia Wan Sulaiman
Age-related macular degeneration (AMD) is the most widely recognised cause of irreversible vision loss and previous studies have suggested that the advancement of wet AMD is influenced by both modifiable and non-modifiable elements. Single nucleotide polymorphism (SNPs) and copy number of variations (CNVs) have been associated with AMD in various populations, however the results are conflicting. Our aim is to determine the CNVs of Complement Factor H-Related genes among Malaysian subjects with wet AMD. 130 patients with wet AMD and 120 healthy controls were included in this research...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#3
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29115893/the-impact-of-epiretinal-membrane-in-neovascular-age-related-macular-degeneration-treatment-a-spectral-domain-optical-coherence-tomography-study
#4
Irini Chatziralli, Panagiotis Stavrakas, George Theodossiadis, Konstantinos Ananikas, Eleni Dimitriou, Panagiotis Theodossiadis
PURPOSE: The purpose of this prospective study was to evaluate the impact of epiretinal membrane (ERM) on anatomical and functional results in patients with wet age-related macular degeneration (AMD) treated with intravitreal anti-vascular endothelial growth (anti-VEGF) injections. METHODS: Participants in the study were 48 patients with either wet AMD alone (AMD group, n = 27) or AMD and ERM (AMD/ERM group, n = 21). All patients received intravitreal anti-VEGF injections (three monthly injections and PRN thereafter) and were followed up for at least 12 months...
November 8, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29089307/ccgs-face-legal-threat-for-offering-off-label-drug-for-wet-amd
#5
Deborah Cohen
No abstract text is available yet for this article.
October 31, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29060156/automated-age-related-macular-degeneration-screening-system-using-fundus-images
#6
P Kunumpol, W Umpaipant, N Kanchanaranya, T Charoenpong, S Vongkittirux, T Kupakanjana, C Tantibundhit
This work proposed an automated screening system for Age-related Macular Degeneration (AMD), and distinguishing between wet or dry types of AMD using fundus images to assist ophthalmologists in eye disease screening and management. The algorithm employs contrast-limited adaptive histogram equalization (CLAHE) in image enhancement. Subsequently, discrete wavelet transform (DWT) and locality sensitivity discrimination analysis (LSDA) were used to extract features for a neural network model to classify the results...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055730/-management-of-wet-amd-in-france-in-2015
#7
J Zerbib, A Bourhis, P L Cornut, F De Bats, V Gualino, J Halfon, H Massé, M Srour, M Streho, S Tick, B Wolff, N San Nicolas
PURPOSE AND CONTEXT: Intravitreal administration of anti-VEGF agents, available in France since 2007, allows stabilization and improvement in visual acuity in wet age-related macular degeneration (AMD). In the past few years, the management of this disease has evolved in terms of both diagnostic methods and treatment schedules, which have been adapted to the pathophysiology of AMD. The goal of this survey, performed in a representative sample of French ophthalmologists, was to describe the evolution of medical practices one year after a similar survey (Massé et al...
November 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29051844/oct-angiography-an-upcoming-non-invasive-tool-for-diagnosis-of-age-related-macular-degeneration
#8
Luiz Roisman, Raquel Goldhardt
PURPOSE: To review the most recent findings, characteristics, faults and future perspectives of optical coherence tomography angiography (OCTA) in age-related macular degeneration (AMD). RECENT FINDINGS: In dry AMD, OCTA is useful on the evaluation of choriocapillaris perfusion and detection of naïve quiescent non-exudative choroidal neovascularization (CNV). In wet AMD, OCTA can provide detailed anatomic and morphologic information of CNVs, which may help to understand why and how they develop and become active...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/29019023/challenges-associated-with-estimating-utility-in-wet-age-related-macular-degeneration-a-novel-regression-analysis-to-capture-the-bilateral-nature-of-the-disease
#9
Robert Hodgson, Timothy Reason, David Trueman, Rose Wickstead, Jeanette Kusel, Adam Jasilek, Lindsay Claxton, Matthew Taylor, Ruth Pulikottil-Jacob
INTRODUCTION: The estimation of utility values for the economic evaluation of therapies for wet age-related macular degeneration (AMD) is a particular challenge. Previous economic models in wet AMD have been criticized for failing to capture the bilateral nature of wet AMD by modelling visual acuity (VA) and utility values associated with the better-seeing eye only. METHODS: Here we present a de novo regression analysis using generalized estimating equations (GEE) applied to a previous dataset of time trade-off (TTO)-derived utility values from a sample of the UK population that wore contact lenses to simulate visual deterioration in wet AMD...
October 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29017506/mortality-in-patients-treated-with-intravitreal-bevacizumab-for-age-related-macular-degeneration
#10
Joel Hanhart, Doron S Comaneshter, Yossi Freier Dror, Shlomo Vinker
BACKGROUND: The aim of this study is to analyze mortality in patients treated with bevacizumab for wet AMD. METHODS: We conducted a retrospective case-control study between patients who received intravitreal injections of bevacizumab as the sole treatment for exudative AMD between September 2008 and October 2014 (n = 5385) and age and gender matched controls (n = 10,756). All individuals included in the study were reviewed for sociodemographic data and comorbidities...
October 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28983894/consecutive-case-series-of-244-age-related-macular-degeneration-patients-undergoing-implantation-with-an-extended-macular-vision-iol
#11
Muhammad A Qureshi, Scott J Robbie, Fritz H Hengerer, Gerd U Auffarth, Ina Conrad-Hengerer, Pablo Artal
PURPOSE: To determine safety and visual outcomes in eyes with age-related macular degeneration (AMD) implanted with a novel intraocular lens (IOL) that delivers an optimized retinal image to all macular areas within 10 degrees of retinal eccentricity. METHODS: This was a consecutive case series of 244 eyes with dry/stable wet AMD and logMAR visual acuity ≥0.3 implanted with iolAMD Eyemax monoTM (London Eye Hospital Pharma), a single-piece, injectable, hydrophobic acrylic IOL sited in the capsular bag...
October 5, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28971147/statins-decrease-vascular-epithelial-growth-factor-expression-via-down-regulation-of-receptor-for-advanced-glycation-end-products
#12
Hiroki Tsujinaka, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Ryogo Shobatake, Mai Makino, Naonori Masuda, Hiromasa Hirai, Shin Takasawa, Nahoko Ogata
AIMS: Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, possess pleiotropic effects that have been extended to modulation of various cellular behaviors. This study aimed to examine whether statins modulate vascular endothelial growth factor A (VEGF-A) expression in human retinal pigment epithelium (RPE) cells. MAIN METHODS: Human RPE cells (h1RPE7), damaged by hydroquinone (HQ) + advanced glycation endproducts (AGE) in an in vitro AMD model, were treated with atorvastatin or lovastatin for 24 h...
September 2017: Heliyon
https://www.readbyqxmd.com/read/28947815/resveratrol-reverses-the-adverse-effects-of-bevacizumab-on-cultured-arpe-19-cells
#13
Murali Subramani, Murugeswari Ponnalagu, Lekshmi Krishna, Nallathambi Jeyabalan, Priyanka Chevour, Anupam Sharma, Chaitra Jayadev, Rohit Shetty, Nargis Begum, Govindaraju Archunan, Debashish Das
Age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR) are one of the major causes of blindness caused by neo-vascular changes in the retina. Intravitreal anti-VEGF injections are widely used in the treatment of wet-AMD and PDR. A significant percentage of treated patients have complications of repeated injections. Resveratrol (RES) is a polyphenol phytoalexin with anti-oxidative, anti-inflammatory and anti-proliferative properties. Hence, we hypothesized that if RES is used in combination with bevacizumab (BEV, anti-VEGF), it could reverse the adverse effects that precipitate fibrotic changes, drusen formation, tractional retinal detachment and so on...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28937825/tanshinone-iia-inhibits-vegf-secretion-and-hif-1%C3%AE-expression-in-cultured-human-retinal-pigment-epithelial-cells-under-hypoxia
#14
Rami M Alzhrani, Qasim Alhadidi, Rinda Devi Bachu, Zahoor Shah, Surajit Dey, Sai Hs Boddu
PURPOSE: The current work intends to study the activity of tanshinone IIA on secretion of vascular endothelial growth factor (VEGF) and expression of hypoxia inducible factor 1α (HIF-1α) in human retinal pigment epithelial cells (ARPE-19 cells) under hypoxic condition. METHODS: The cytotoxicity of tanshinone IIA was tested in ARPE-19 cells by MTT assay. ARPE-19 cells were incubated with different concentrations of cobalt chloride (100, 150, and 200 µM) for 12 h, and levels of expressed HIF-1α and secreted VEGF were quantified through Western blot and ELISA, respectively...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28930884/rate-of-macular-ganglion-cell-inner-plexiform-layer-thinning-in-glaucomatous-eyes-with-vascular-endothelial-growth-factor-inhibition
#15
Won June Lee, Young Kook Kim, Yong Woo Kim, Jin Wook Jeoung, Seok Hwan Kim, Jang Won Heo, Hyeong Gon Yu, Ki Ho Park
PURPOSE: To evaluate the rate of progressive macular ganglion cell-inner plexiform layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal antivascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS: This study was a retrospective modified case control study with fellow eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography...
November 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28922378/relationships-of-orientation-discrimination-threshold-and-visual-acuity-with-macular-lesions-in-age-related-macular-degeneration
#16
Haojie Fu, Bin Zhang, Jianliang Tong, Harold Bedell, Hecheng Zhang, Yating Yang, Chaochao Nie, Yingdong Luo, Xiaoling Liu
PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28916483/recombinant-humanized-anti-vascular-endothelial-growth-factor-monoclonal-antibody-efficiently-suppresses-laser-induced-choroidal-neovascularization-in-rhesus-monkeys
#17
Wan-Wan Ji, Dong-An Yu, Peng Yang, Peng Fang, Yu-Xia Cao, Hu Li, Ning Xie, Shou-Sheng Yan
Neovascular age-related macular degeneration, characterized by abnormal choroidal neovascularization (CNV), is a major cause of blindness worldwide. Anti-vascular endothelial growth factor (VEGF) antibodies have demonstrated significant efficacy in improving visual acuity. TMAB001 is a new recombinant humanized rabbit anti-VEGF monoclonal antibody. It presents high activities in vitro studies. In the binding affinity assay, TMAB001 exhibited a high binding capability to VEGF with an affinity constant of 10(-11)M...
September 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28874192/plasma-metabolomic-study-in-chinese-patients-with-wet-age-related-macular-degeneration
#18
Dan Luo, Tingting Deng, Wei Yuan, Hui Deng, Ming Jin
BACKGROUND: Age-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences. METHODS: We used ultra-high-pressure liquid chromatography and quadrupole-time-of-flight mass spectrometry for this analysis. The relationship of these differences with AMD pathophysiology was also assessed...
September 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28860733/recent-developments-in-age-related-macular-degeneration-a-review
#19
REVIEW
Waseem M Al-Zamil, Sanaa A Yassin
BACKGROUND: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. OBJECTIVE: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28852052/tgf-%C3%AE-participates-choroid-neovascularization-through-smad2-3-vegf-tnf-%C3%AE-signaling-in-mice-with-laser-induced-wet-age-related-macular-degeneration
#20
Xiaolei Wang, Wei Ma, Song Han, Zhaoyang Meng, Lu Zhao, Yi Yin, Yanling Wang, Junfa Li
Choroidal neovascularization(CNV) is the most severe complication in Age-related macular degeneration(AMD) and the most common cause of irreversible blindness in the elderly in developed world. The aim of this study was to identify the effect of transforming growth factor-β(TGF-β) and Smad2/3-VEGF/TNF-α signaling on CNV angiopoiesis, and to explore TGF-β inhibitors on the development of CNV in a CNV mouse model. Fundus fluorescein angiography(FFA) was used to evaluate the laser-induced CNV formation. The histology of CNV lesions stained with hematoxylin-eosin(HE) was obtained...
August 29, 2017: Scientific Reports
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