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https://www.readbyqxmd.com/read/28440245/pluripotent-stem-cells-a-therapeutic-source-for-age-related-macular-degeneration
#1
REVIEW
Sowmya Parameswaran, Subramanian Krishnakumar
Age-related macular degeneration (AMD) leads to progressive loss of central vision in the elderly. At a cellular level, there is aging of the retinal pigment epithelial (RPE) cells, and accumulation of lipofuscin that interferes with the proper functioning of RPE which eventually leads to apoptosis. Treatment depends on the stage of the disease. Wet AMD which has neovascularization is managed by local therapies such as laser photocoagulation and photodynamic therapy and is managed with injections of antivascular endothelial growth factor-based therapy...
March 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28435212/testing-the-clinical-value-of-multifocal-electroretinography-and-microperimetry-and-the-effects-of-intravitreal-therapy-with-ranibizumab-on-macular-function-in-the-course-of-wet-age-related-macular-degeneration-a-1-year-prospective-study
#2
Mihaela Reinsberg, Ralf-Dieter Hilgers, Inger Lüdeke, Khaled Nassar, Swaantje Grisanti, Salvatore Grisanti, Julia Lüke, Matthias Lüke
PURPOSE: To investigate the clinical value of multifocal electroretinography (mfERG) and microperimetry and the effects of intravitreal therapy with ranibizumab (Lucentis(®)) on macular function in the course of neovascular age-related macular degeneration (nAMD). MATERIALS AND METHODS: We conducted a prospective single-arm interventional cohort study with 20 nAMD patients older than 50 years. Examinations were scheduled monthly for 1 year during intravitreal therapy with ranibizumab...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28399772/nurse-led-ranibizumab-intravitreal-injections-in-wet-age-related-macular-degeneration-a-literature-review
#3
Emma Gregg
Aim The aim of this literature review was to explore the development of the role of specialist ophthalmic nurses in delivering ranibizumab intravitreal injections to patients with wet age-related macular degeneration (AMD), and to evaluate their contribution to reducing capacity pressures in medical retina services, while maintaining safe and effective standards of care. Method A systematic literature search was undertaken to identify relevant articles published between January 2000 and June 2015. A search of electronic databases was undertaken, and selected relevant journals were searched manually...
April 12, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28391615/choroidal-vascular-changes-in-age-related-macular-degeneration
#4
Lilian Hui Li Koh, Rupesh Agrawal, Neha Khandelwal, Labishetty Sai Charan, Jay Chhablani
PURPOSE: To assess the choroidal vascular changes using choroidal vascularity index (CVI) in patients with age-related macular degeneration (AMD) compared to controls. METHODS: Enhanced depth imaging (EDI) optical coherence tomography (OCT) scans of 64 patients with unilateral or bilateral AMD were obtained. Images with a poorly demarcated choroidal-scleral interface (CSI) were excluded from the analysis. Foveal scans of 63 AMD eyes and 35 'normal fellow' eyes were analysed...
April 9, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28380648/-polysialic-acid-for-immunomodulation-in-an-animal-model-for-wet-age-related-macular-degeneration-amd
#5
Thomas Langmann, Sascha Fauser
Background Chronic activation of the innate immune system is a hallmark of retinal degenerative diseases, including age-related macular degeneration (AMD). Overt microglia and macrophage reactivity, as well as dysregulation of the alternative complement system, trigger and sustain retinal degeneration. It is now accepted that there exists a vicious cycle of mononuclear phagocyte reactivity, abnormal intrinsic complement activation, damage of Bruch's membrane, dysfunction of the retinal pigment epithelium, photoreceptor degeneration and choroidal neovascularization (CNV)...
April 5, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28377496/ferrochelatase-is-a-therapeutic-target-for-ocular-neovascularization
#6
Halesha D Basavarajappa, Rania S Sulaiman, Xiaoping Qi, Trupti Shetty, Sardar Sheik Pran Babu, Kamakshi L Sishtla, Bit Lee, Judith Quigley, Sameerah Alkhairy, Christian M Briggs, Kamna Gupta, Buyun Tang, Mehdi Shadmand, Maria B Grant, Michael E Boulton, Seung-Yong Seo, Timothy W Corson
Ocular neovascularization underlies major blinding eye diseases such as "wet" age-related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and refractory patient populations necessitate discovery of new therapeutic targets. Using a forward chemical genetic approach, we identified the heme synthesis enzyme ferrochelatase (FECH) as necessary for angiogenesis in vitro and in vivo FECH is overexpressed in wet AMD eyes and murine choroidal neovascularization; siRNA knockdown of Fech or partial loss of enzymatic function in the Fech(m1Pas) mouse model reduces choroidal neovascularization...
April 4, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28318717/-individualized-management-of-patients-with-exudative-amd-ioi-protocol-injection-observational-individualization
#7
O Semoun, S Y Cohen, M Srour, C Creuzot-Garchet, H Oubraham-Mebroukine, L Kodjikian, F Devin, E H Souied
Wet macular degeneration remains a major cause of visual impairment in people over 55years. Through a group of experts belonging to the Federation France Macula, we review the treatment of wet AMD and provide recommendation with a 3 phases protocol called IOI.
March 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28315863/circulating-mirnas-as-potential-biomarkers-of-age-related-macular-degeneration
#8
Chengda Ren, Qingyu Liu, Qingquan Wei, Wenting Cai, Mengmei He, Yaru Du, Ding Xu, Yan Wu, Jing Yu
Backgroud: Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness of the elder people. This research was intended to demonstrate the different expression of microRNAs (miRNA) in AMD patients and whether they can be used as biomarkers for AMD. METHODS: MiRNAs expression was measured by microarray of 6 AMD cases and 6 gender matched controls. In a larger-sample case-control study with 126 AMD cases and 140 controls, whole blood samples were detected for the differences of miRNA expression...
March 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28260367/-the-pharmacogenomics-of-cfh-y402h-and-wet-age-related-macular-degeneration
#9
L L Chen, Y Y Chen
Age-related macular degeneration(AMD) is one of the main leading causes of irreversible vision damage in patients over 50 years old. Genetic factors play an important role in the occurrence and development of AMD. Since the significant correlation between complement factor H (CFH) gene and AMD was found, the pharmacogenomics of CFH polymorphism was paid close attention by academic circles. Among which, studies concerning CFH Y402H were more deeply. Studies have found CFH Y402H genotypes might lead to differences toward the outcome of PDT and anti-VEGF treatment...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251084/the-vitreomacular-interface-in-different-types-of-age-related-macular-degeneration
#10
Mohamed Abd ElMonaem El-Hifnawy, Hisham Ali Ibrahim, Amir Ramadan Gomaa, Mohamed A Elmasry
AIM: To evaluate the vitreomacular interface in cases with wet age-related macular degeneration (AMD) and to compare them to eyes with dry AMD and normal eyes. METHODS: This was a cross-sectional comparative study that included 87 eyes with wet AMD, 42 eyes with dry AMD and 40 eyes without AMD as a control group. Optical coherence tomography (OCT) examination was performed for all patients to assess the vitreomacular interface. RESULTS: In the wet AMD group, 34...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28245970/gene-therapy-in-neovascular-age-related-macular-degeneration-three-year-follow-up-of-a-phase-1-randomised-dose-escalation-trial
#11
Ian J Constable, Chooi-May Lai, Aaron L Magno, Martyn A French, Samuel B Barone, Steven D Schwartz, Mark S Blumenkranz, Mariapia A Degli-Esposti, Elizabeth P Rakoczy
PURPOSE: To assess the safety of rAAV.sFlt-1 subretinal injection in neovascular age-related macular degeneration (wet AMD) over 36 months. DESIGN: Phase 1 dose escalation trial. METHODS: Eight subjects with advanced, treatment-experienced wet AMD were randomly assigned (3:1) to treatment and non-gene therapy control groups. Eligible subjects were ≥65 years, had wet AMD and best corrected visual acuity (BCVA) 10/200 -20/80 in the study eye and 20/200 or better in the other eye...
February 25, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28152206/nursing-actions-that-create-a-sense-of-good-nursing-care-in-patients-with-wet-age-related-macular-degeneration
#12
Åsa Emsfors, Lennart Christensson, Carina Elgán
BACKGROUND: People who suffer from wet age-related macular degeneration (AMD) risk central vision loss. Treatment with anti-VEGF is the only available option at present that preserves vision and no definitive cure currently exists. Patients feel that they are compelled to accept this treatment because they might otherwise become blind. AIM: To identify and describe nursing actions performed by nurses that create a sense of good nursing care in patients with wet (AMD)...
February 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28046346/su-g-tep3-05-in-vitro-demonstration-of-endothelial-dose-enhancement-due-to-gold-nanoparticles-during-low-voltage-radiotherapy
#13
S Yasmin-Karim, M Moreau, R Kumar, G M Makrigiorgos, J Hanlon, M Arnoldussen, J Hempstead, J Celli, W Ngwa
PURPOSE: Oraya Therapy uses low-voltage, stereotactic, highly targeted X-rays for the treatment of wet age-related macular degeneration (AMD) - offering a new option for patients worldwide. Neovascular endothelial cells play a crucial role in the pathogenesis of this disease. This in-vitro study investigates the potential of gold nanoparticles (GNP) to enhance endothelial cell damage during low-voltage radiotherapy towards potential applications in the treatment of wet-AMD. METHODS: Primary human umbilical cord vein endothelium cells (HUVEC) were treated with 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28008222/evaluation-of-peripheral-fundus-autofluorescence-in-eyes-with-wet-age-related-macular-degeneration
#14
Tetsuyuki Suetsugu, Aki Kato, Munenori Yoshida, Tsutomu Yasukawa, Akiko Nishiwaki, Norio Hasegawa, Hideaki Usui, Yuichiro Ogura
PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28005632/association-between-the-vitreomacular-interface-and-optical-coherence-tomography-characteristics-in-wet-age-related-macular-degeneration
#15
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
PURPOSE: To study the effect of the vitreomacular interface on various wet age-related macular degeneration (AMD) characteristics including the size and type of choroidal neovascularization (CNV), choroidal thickness, and activity of the CNV. METHODS: This was a retrospective observational cross-sectional study. The study included 43 patients (51 eyes) with treatment-naive age-related macular degeneration. Twenty-six patients with wet AMD in one eye and dry AMD in the other eye were included in a paired-eye analysis...
December 21, 2016: Retina
https://www.readbyqxmd.com/read/28003780/aflibercept-in-refractory-wet-amd-treated-with-ranibizumab-anatomical-and-visual-outcome
#16
Sleiman Abou-Ltaif
PURPOSE: To assess the anatomical outcome of patients with exudative age-related macular degeneration resistant to ranibizumab treated with aflibercept. METHOD: Prospective, interventional, case series, where we treated a group of patients deemed resistant to Ranibizumab after 6 months of persistence of intra- or subretinal fluid despite continuous treatment. RESULTS: The study included 17 patients, 3 males and 14 females. The average males age was 85 (range 83-87), and that of females was 79...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28003009/hot-topics-in-dry-amd
#17
Raja Narayanan, Baruch D Kuppermann
BACKGROUND: The global prevalence of AMD is projected to be 196 million by the year 2020. Despite substantial progress in the development of new therapies for wet AMD using inhibition of vascular endothelial growth factor (VEGF), the severe visual impairment associated with geographic atrophy in dry AMD remains untreatable. A number of therapeutic options for dry AMD are being developed and are in various stages of clinical trials. METHODS: Review of literature...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28003006/hot-topics-in-dry-amd
#18
Raja Narayanan, Baruch D Kuppermann
substantial progress in the development of new therapies for wet AMD using inhibition of vascular endothelial growth factor (VEGF), the severe visual impairment associated with geographic atrophy in dry AMD remains untreatable. A number of therapeutic options for dry AMD are being developed and are in various stages of clinical trials. METHODS: Review of literature. RESULTS: Enhancers of choroidal blood flow, neuroprotectants and anti-complement factors are the key targets in the research for the treatment of dry AMD...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27966830/homocysteine-and-risk-of-age-related-macular-degeneration-a-systematic-review-and-meta-analysis
#19
REVIEW
Antonio Pinna, Francesco Zaccheddu, Francesco Boscia, Ciriaco Carru, Giuliana Solinas
There is still no agreement on total plasma homocysteine (tHcy) role in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries. We performed a systematic review and meta-analysis of the published data on the correlation between tHcy and AMD. MEDLINE/PubMed and ISI Web of Sciences searches were performed according to MOOSE guidelines. Case-control studies were eligible for inclusion. Participants and controls were AMD patients and subjects without AMD. The main outcome measure was wet AMD...
December 14, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27928444/the-remote-effects-of-intravitreal-anti-vegf-therapy
#20
F Balta, M Merticariu, C Taban, G Neculau, A Merticariu, D Muresanu, D Badescu, V Jinga
Objective: To study the effects of intravitreal anti-Vascular Endothelial Growth Factor (VEGF) therapy with Avastin for wet Age-Related Macular Degeneration (AMD) on Benign Prostatic Hyperplasia (BPH)-related symptoms. Methods: An exploratory trial was conducted from August 1, 2013 to February 1, 2014, that included 14 male patients previously diagnosed with BPH, who were aged between 59 and 69 years. The trial was performed in Bucharest and involved two medical institutions: the Clinical Hospital of Eye Emergencies and the "Prof...
October 2016: Journal of Medicine and Life
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