keyword
MENU ▼
Read by QxMD icon Read
search

expert systems

keyword
https://www.readbyqxmd.com/read/27933492/comparative-analysis-of-speech-impairment-and-upper-limb-motor-dysfunction-in-parkinson-s-disease
#1
Jan Rusz, Tereza Tykalová, Radim Krupička, Kateřina Zárubová, Michal Novotný, Robert Jech, Zoltán Szabó, Evžen Růžička
It is currently unknown whether speech and limb motor effectors in Parkinson's disease (PD) are controlled by similar underlying brain processes. Based on computerized objective analysis, the aim of this study was to evaluate potential correlation between speech and mechanical tests of upper limb motor function. Speech and upper limb motor tests were performed in 22 PD patients and 22 healthy controls. Quantitative acoustic analyses of eight key speech dimensions of hypokinetic dysarthria, including quality of voice, sequential motion rates, consonant articulation, vowel articulation, average loudness, loudness variability, pitch variability, and number of pauses, were performed...
December 8, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27933282/myocardial-perfusion-scintigraphy-dosimetry-optimal-use-of-spect-and-spect-ct-technologies-in-stress-first-imaging-protocol
#2
REVIEW
M Lecchi, S Malaspina, C Scabbio, V Gaudieri, A Del Sole
PURPOSE: Over the past decade, nuclear medicine experts have been seeking to minimize patient exposure to radiation in myocardial perfusion scintigraphy (MPS). This review describes the latest technological innovations in MPS, particularly with regard to dose reduction. METHODS: We searched in PubMed for original clinical papers in English, published after 2008, using the following research criteria: (dose) and ((reduction) or (reducing)) and ((myocardial) or (cardiac) or (heart)) and ((nuclear medicine) or (nuclear imaging) or (radionuclide) or (scintigraphy) or (SPET) or (SPECT))...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27932910/ascidiacea-chordata-tunicata-of-greece-an-updated-checklist
#3
Chryssanthi Antoniadou, Vasilis Gerovasileiou, Nicolas Bailly
BACKGROUND: The checklist of the ascidian fauna (Tunicata: Ascidiacea) of Greece was compiled within the framework of the Greek Taxon Information System (GTIS), an application of the LifeWatchGreece Research Infrastructure (ESFRI) aiming to produce a complete checklist of species recorded from Greece. This checklist was constructed by updating an existing one with the inclusion of recently published records. All the reported species from Greek waters were taxonomically revised and cross-checked with the Ascidiacea World Database...
2016: Biodiversity Data Journal
https://www.readbyqxmd.com/read/27932631/dying-in-the-hospital-setting-a-meta-synthesis-identifying-the-elements-of-end-of-life-care-that-patients-and-their-families-describe-as-being-important
#4
REVIEW
Claudia Virdun, Tim Luckett, Karl Lorenz, Patricia M Davidson, Jane Phillips
BACKGROUND: Despite most expected deaths occurring in hospital, optimal end-of-life care is not available for all in this setting. AIM: To gain a richer and deeper understanding of elements of end-of-life care that consumers consider most important within the hospital setting. DESIGN: A meta-synthesis. DATA SOURCES: A systematic search of Academic Search Complete, AMED, CINAHL, MEDLINE, EMBASE, PsycINFO, PubMed, Google, Google Scholar and CareSearch for qualitative studies published between 1990 and April 2015 reporting statements by consumers regarding important elements of end-of-life hospital care...
December 8, 2016: Palliative Medicine
https://www.readbyqxmd.com/read/27931638/complications-of-diagnostic-and-therapeutic-endoscopic-ultrasound
#5
REVIEW
Sundeep Lakhtakia
Endoscopic Ultrasound (EUS) provides the unique opportunity to visualize, interrogate and intervene gastrointestinal (GI) luminal, mural or peri-luminal structures and pathology with negligible adverse effects. Diagnostic, upper GI and rectal EUS is feasible, extremely safe, and efficacious. Most EUS guided interventions are safe, effective and minimally invasive, compared to peers in the percutaneous radiological or surgical procedures. As with any endoscopic procedure, EUS and its guided interventions may be accompanied by adverse events...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27931077/antibiotics-for-the-neurological-complications-of-lyme-disease
#6
REVIEW
Diego Cadavid, Paul G Auwaerter, Jeffrey Rumbaugh, Harald Gelderblom
BACKGROUND: Various central nervous system-penetrant antibiotics are bactericidal in vitro and in vivo against the causative agent of Lyme neuroborreliosis (LNB), Borrelia burgdorferi. These antibiotics are routinely used clinically to treat LNB, but their relative efficacy is not clear. OBJECTIVES: To assess the effects of antibiotics for the treatment of LNB. SEARCH METHODS: On 25 October 2016 we searched the Cochrane Neuromuscular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase...
December 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27930676/stochastic-simulation-service-bridging-the-gap-between-the-computational-expert-and-the-biologist
#7
Brian Drawert, Andreas Hellander, Ben Bales, Debjani Banerjee, Giovanni Bellesia, Bernie J Daigle, Geoffrey Douglas, Mengyuan Gu, Anand Gupta, Stefan Hellander, Chris Horuk, Dibyendu Nath, Aviral Takkar, Sheng Wu, Per Lötstedt, Chandra Krintz, Linda R Petzold
We present StochSS: Stochastic Simulation as a Service, an integrated development environment for modeling and simulation of both deterministic and discrete stochastic biochemical systems in up to three dimensions. An easy to use graphical user interface enables researchers to quickly develop and simulate a biological model on a desktop or laptop, which can then be expanded to incorporate increasing levels of complexity. StochSS features state-of-the-art simulation engines. As the demand for computational power increases, StochSS can seamlessly scale computing resources in the cloud...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27930094/cancer-stem-cell-hypothesis-for-therapeutic-innovation-in-clinical-oncology-taking-the-root-out-not-chopping-the-leaf
#8
Kevin Dzobo, Dimakatso Alice Senthebane, Arielle Rowe, Nicholas Ekow Thomford, Lamech M Mwapagha, Nasir Al-Awwad, Collet Dandara, M Iqbal Parker
Clinical oncology is in need of therapeutic innovation. New hypotheses and concepts for translation of basic research to novel diagnostics and therapeutics are called for. In this context, the cancer stem cell (CSC) hypothesis rests on the premise that tumors comprise tumor cells and a subset of tumor-initiating cells, CSCs, in a quiescent state characterized by slow cell cycling and expression of specific stem cell surface markers with the capability to maintain a tumor in vivo. The CSCs have unlimited self-renewal abilities and propagate tumors through division into asymmetric daughter cells...
December 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27930092/inflammatory-bowel-disease-meets-systems-biology-a-multi-omics-challenge-and-frontier
#9
Orazio Palmieri, Tommaso Mazza, Stefano Castellana, Anna Panza, Tiziana Latiano, Giuseppe Corritore, Angelo Andriulli, Anna Latiano
The inflammatory bowel disease (IBD) is a systemic disease that is characterized by the inflammation of the gastrointestinal tract. It includes ulcerative colitis and the Crohn's disease. Presently, IBD is one of the most investigated common complex human disorders, although its causes remain unclear. Multi-omics mechanisms involving genomic, transcriptomic, proteomic, and epigenomic variations, not to forget the miRNome, together with environmental contributions, result in an impairment of the immune system in persons with IBD...
December 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27929247/initial-management-of-patients-with-hiv-infection
#10
Ronald H Goldschmidt, Carolyn Chu, Betty J Dong
Human immunodeficiency virus (HIV) infection has become a treatable chronic disease with near-normal life expectancy when patients receive antiretroviral therapy (ART). Family physicians and other primary care clinicians commonly provide long-term comprehensive care for persons with HIV infection. This article describes the scope of initial care, including obtaining a thorough history; physical examination for HIV-associated manifestations; attention to HIV-specific immunization schedules; routine and HIV-specific laboratory evaluation; and ensuring standard health care maintenance to prevent HIV- and non-HIV-related morbidity and mortality...
November 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27928669/analysis-of-motion-in-laparoscopy-the-deconstruction-of-an-intra-corporeal-suturing-task
#11
Monica A Farcas, Maeve O'Neill Trudeau, Ahmed Nasr, J Ted Gerstle, Brian Carrillo, Georges Azzie
BACKGROUND: This study analyzes instrument motion for segments of a defined intra-corporeal suturing task in a laparoscopic simulator. We describe a system providing real-time velocity and acceleration assessment in the performance of this task. Analysis of the deconstructed task segments allows targeted assessment and teaching. METHODS: A traditional box trainer was fitted with a custom-built motion-tracking system. Participants were stratified into novice, intermediate and expert groups...
December 7, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27928658/analog-computer-aided-detection-cad-information-can-be-more-effective-than-binary-marks
#12
Corbin A Cunningham, Trafton Drew, Jeremy M Wolfe
In socially important visual search tasks, such as baggage screening and diagnostic radiology, experts miss more targets than is desirable. Computer-aided detection (CAD) programs have been developed specifically to improve performance in these professional search tasks. For example, in breast cancer screening, many CAD systems are capable of detecting approximately 90% of breast cancer, with approximately 0.5 false-positive detections per image. Nevertheless, benefits of CAD in clinical settings tend to be small (Birdwell, 2009) or even absent (Meziane et al...
December 7, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27927053/future-therapies-targeted-towards-eliminating-candida-biofilms-and-associated-infections
#13
H M H N Bandara, V H Matsubara, L P Samaranayake
Candida species are common human commensals and cause either superficial or invasive opportunistic infections. The biofilm form of Candida as opposed to its suspended, planktonic form, is predominantly associated with these infections. Alternative or adjunctive therapies are urgently needed to manage Candida infections as the currently available short arsenal of antifungal drugs has been compromised due to their systemic toxicity, cross-reactivity with other drugs, and above all, by the emergence of drug-resistant Candida species due to irrational drug use...
December 7, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27927046/advances-in-chemical-pharmacotherapy-to-manage-advanced-breast-cancer
#14
Andrea Gombos, Ahmad Awada
Advanced breast cancer is still incurable. However, patients diagnosed with this fatal disease live longer. The selection of systemic therapy is mainly based on molecular subtype. The aim of management in these patients is to not only improve outcome, but also to maintain quality of life. Areas covered: In this paper we focus on available treatments and drugs under late development in the three main subtypes of breast cancer: luminal (hormone receptor positive), HER2 positive and triple negative disease. Main advances during the last years have been made in the treatment of HER2 positive breast cancer with the approval of several new targeted agents...
December 7, 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27927042/pharmacological-treatments-for-methamphetamine-addiction-current-status-and-future-directions
#15
Javier Ballester, Gerald Valentine, Mehmet Sofuoglu
Methamphetamine (MA) abuse remains a global health challenge despite intense research interest in the development of pharmacological treatments. This review provides a summary of clinical trials and human studies on the pharmacotherapy of methamphetamine use disorder (MUD). Areas Covered: We summarize published clinical trials that tested candidate medications for MUD and also conducted PubMed and Google Scholar searches to identify recently completed clinical trials using the keywords "methamphetamine" "addiction" "pharmacotherapy" and "clinical trial...
December 7, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27927040/hydroxychloroquine-in-systemic-lupus-erythematosus-sle
#16
C Ponticelli, G Moroni
Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus (SLE). Areas covered. In this review the mechanisms of action, the efficacy, and the safety of HCQ in the management of patients with SLE have been reviewed. HCQ may reduce the risk of flares, allow the reduction of the dosage of steroids, reduce organ damage, and prevent the thrombotic effects of anti-phospholipid antibodies...
December 7, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27927032/emerging-drugs-for-the-treatment-of-obesity
#17
Christoffer Martinussen, Kirstine Nyvold Bojsen-Moller, Maria Saur Svane, Thomas Fremming Dejgaard, Sten Madsbad
The increasing prevalence of obesity represents a huge threat to public health and the current pharmacological treatment options are limited. Bariatric surgery is by far the most effective treatment for severe obesity, highlighting the urgent need for new and improved drug therapies. Areas covered: Based on the physiological regulation of energy homeostasis, pharmacological strategies to treat obesity are evaluated with focus on drugs in phase 2 and 3 clinical development. The potential impact of these drugs on current treatment standards and the barriers for development are discussed and set in a historical perspective of previous anti-obesity medications...
December 7, 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27926547/liver-redistricting-what-are-the-upcoming-changes-in-liver-allocation-in-the-united-states
#18
Therese Bittermann, David S Goldberg
PURPOSE OF REVIEW: Geographic disparity in liver transplantation is substantial in the United States, and primarily a byproduct of artificially created zones of organ distribution. In 2016, the United Network for Organ Sharing (UNOS) put forward a formal redistricting proposal with the goal of reducing this variability by regrouping the country's 58 donation service areas into eight new districts. This review provides a summary of the redistricting proposal's methodologies, expected results, criticisms and next steps...
December 6, 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27925585/using-contact-forces-and-robot-arm-accelerations-to-automatically-rate-surgeon-skill-at-peg-transfer
#19
Jeremy Brown, Conor O'Brien, Sarah Leung, Kristoffel Dumon, David Lee, Katherine Kuchenbecker
OBJECTIVE: Most trainees begin learning robotic minimally invasive surgery by performing inanimate practice tasks with clinical robots such as the Intuitive Surgical da Vinci. Expert surgeons are commonly asked to evaluate these performances using standardized five-point rating scales, but doing such ratings is time consuming, tedious, and somewhat subjective. This article presents an automatic skill evaluation system that analyzes only the contact force with the task materials, the broad-bandwidth accelerations of the robotic instruments and camera, and the task completion time...
December 2, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27925401/dickeya-dadantii-pectic-enzymes-necessary-for-virulence-are-also-responsible-for-activation-of-the-arabidopsis-thaliana-innate-immune-system
#20
Dominique Expert, Oriane Patrit, Vladimir E Shevchik, Claude Perino, Virginie Boucher, Creze Christophe, Estelle Wenes, Mathilde Fagard
Soft-rot diseases of plants attributed to Dickeya dadantii result from lysis of plant cell wall due to pectic enzymes released by the bacterial cell by a type II secretion system (T2SS). A. thaliana can express several lines of defence against this bacterium. We employed bacterial mutants with defective envelope structures or secreted proteins to examine early plant defence reactions. We focused on the production of AtrbohD-dependent ROS, callose deposition and cell death as indicators of these reactions. We observed a significant reduction in ROS and callose formation with a bacterial mutant where genes encoding five pectate lyases (Pels) were disrupted...
December 7, 2016: Molecular Plant Pathology
keyword
keyword
53815
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"