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https://www.readbyqxmd.com/read/29913090/oral-chemotherapy-for-the-treatment-of-hepatocellular-carcinoma
#1
Shun Yamamoto, Shunsuke Kondo
Many clinical trials have been conducted with chemotherapies in patients with advanced hepatocellular carcinoma (HCC). However, few agents have shown efficacy. It is thought that the efficacy of some agents might have resulted from the heterogeneity of tumors, insufficient dosages due to liver cirrhosis, and post-therapy effects. In recent years, immune checkpoint inhibitors have shown promising clinical activity and safety in patients with advanced HCC. Areas covered: The authors provide an overview of chemotherapies used for the treatment of HCC, including ongoing trials...
June 18, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29911981/haptic-feedback-for-control-and-active-constraints-in-contactless-laser-surgery-concept-implementation-and-evaluation
#2
Emidio Olivieri, Giacinto Barresi, Darwin G Caldwell, Leonardo S Mattos
Haptics has proven to be highly beneficial in surgical robotics, bringing enhanced safety and precision by complementing the surgeon's visual channel. However, most of the research body in this context is dedicated to applications involving traditional "cold steel" surgical instruments. This paper proposes to bring the benefits of haptics to contactless surgeries, and presents a novel method to achieve this. The specific case of robot-assisted laser microsurgery is investigated. Here, a fictitious force feedback is created through stereoscopic visualization and 3D reconstruction, allowing the surgeon to sense the surgical area haptically while controlling a non-contact surgical laser...
April 2018: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/29911915/targeting-glucose-dependent-insulinotropic-polypeptide-receptor-for-neurodegenerative-disorders
#3
Mahip K Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V S Nemmani
Incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide (GLP-1) exert pleiotropic effects on the endocrine pancreas and nervous system. Expression of GIP and GIP receptor (GIPR) in neurons, their roles in neurogenesis, synaptic plasticity, neurotransmission and neuromodulation, uniquely positions GIPR for therapeutic applications in neurodegenerative disorders. GIP analogues acting as GIPR agonists attenuate neurobehavioral and neuropathological sequelae of neurodegenerative disorders in preclinical models, e...
June 18, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29911913/budget-impact-analysis-of-demineralised-bone-matrix-in-combination-with-autograft-in-lumbar-spinal-fusion-procedures-for-the-treatment-of-lumbar-degenerative-disc-disease-in-spain
#4
Kirk Geale, María Álvarez, Maria Polyzoi, Xavier Màlaga, Cristina Pineda, César Hernández
OBJECTIVE: Estimate the budget impact (BI) of introducing local autograft (LA) combined with demineralized bone matrix (LA+DBM) in lumbar spinal fusion (LSF) procedures to treat lumbar degenerative disc disease (LDDD) in Spain. METHODS: A decision tree model was developed to evaluate the 4-year BI associated with introducing LA+DBM putty to replace currently available grafting methods including iliac crest bone graft (ICBG), LA alone, and LA combined with beta-tricalcium phosphate (LA+ceramics), with 30%, 40%, and 30% market shares, respectively...
June 18, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29911409/the-ottawa-panel-guidelines-on-programmes-involving-therapeutic-exercise-for-the-management-of-hand-osteoarthritis
#5
Lucie Brosseau, Odette Thevenot, Olivia MacKiddie, Jade Taki, George A Wells, Paulette Guitard, Guillaume Léonard, Nicole Paquet, Sibel Z Aydin, Karine Toupin-April, Sabrina Cavallo, Rikke Helene Moe, Kamran Shaikh, Wendy Gifford, Laurianne Loew, Gino De Angelis, Shirin Mehdi Shallwani, Ala' S Aburub, Aline Mizusaki Imoto, Prinon Rahman, Inmaculada C Álvarez Gallardo, Milkana Borges Cosic, Nina Østerås, Sabrina Lue, Tokiko Hamasaki, Nathaly Gaudreault, Tanveer E Towheed, Sahil Koppikar, Ingvild Kjeken, Dharini Mahendira, Glen P Kenny, Gail Paterson, Marie Westby, Lucie Laferrière, Guy Longchamp
OBJECTIVE: To identify programmes involving therapeutic exercise that are effective for the management of hand osteoarthritis and to provide stakeholders with updated, moderate to high-quality recommendations supporting exercises for hand osteoarthritis. METHODS: A systematic search and adapted selection criteria included comparable trials with exercise programmes for managing hand osteoarthritis. Based on the evaluated evidence, a panel of experts reached consensus through a Delphi approach endorsing the recommendations...
June 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29911299/overview-on-radiation-and-tissue-banking-in-latin-america
#6
Eulogia Kairiyama, Maria Esther Martínez Pardo, Eddy Sánchez Noda, Isabel Otero
The International Atomic Energy Agency (IAEA) played an important role in the establishment of new tissue banks and the improvement of already existing ones in Latin America. The Agency strongly supported, through regional, interregional and national technical cooperation projects, providing equipment, expert missions and training for the production and application of human tissues for transplantation. From 1999 to 2005 five regional courses were given in Buenos Aires under the modality of 1-year distance learning training courses and 1-week face to face courses...
June 18, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29908876/prostate-imaging-reporting-and-data-system-steering-committee-pi-rads-v2-status-update-and-future-directions
#7
Anwar R Padhani, Jeffrey Weinreb, Andrew B Rosenkrantsz, Geert Villeirs, Baris Turkbey, Jelle Barentsz
CONTEXT: The Prostate Imaging-Reporting and Data System (PI-RADS) v2 analysis system for multiparametric magnetic resonance imaging (mpMRI) detection of prostate cancer (PCa) is based on PI-RADS v1, accumulated scientific evidence, and expert consensus opinion. OBJECTIVE: To summarize the accuracy, strengths and weaknesses of PI-RADS v2, discuss pathway implications of its use and outline opportunities for improvements and future developments. EVIDENCE ACQUISITION: For this consensus expert opinion from the PI-RADS steering committee, clinical studies, systematic reviews, and professional guidelines for mpMRI PCa detection were evaluated...
June 13, 2018: European Urology
https://www.readbyqxmd.com/read/29907271/automation-of-mechanical-ventilation
#8
REVIEW
Richard D Branson
Closed loop control of mechanical ventilation is routine and operates behind the ventilator interface. Reducing caregiver interactions is neither an advantage for the patient or the staff. Automated systems causing lack of situational awareness of the intensive care unit are a concern. Along with autonomous systems must come monitoring and displays that display patients' current condition and response to therapy. Alert notifications for sudden escalation of therapy are required to ensure patient safety. Automated ventilation is useful in remote settings in the absence of experts...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907242/does-culture-affect-usability-a-trans-european-usability-and-user-experience-assessment-of-a-falls-risk-connected-health-system-following-a-user-centred-design-methodology-carried-out-in-a-single-european-country
#9
Vera Stara, Richard Harte, Mirko Di Rosa, Liam Glynn, Monica Casey, Patrick Hayes, Lorena Rossi, Anat Mirelman, Paul M A Baker, Leo R Quinlan, Gearóid ÓLaighin
BACKGROUND: User-centred design (UCD) is a process whereby the end-user is placed at the centre of the design process. The WIISEL (Wireless Insole for Independent and Safe Elderly Living) system is designed to monitor fall risk and to detect falls, and consists of a pair of instrumented insoles and a smartphone app. The system was designed using a three-phase UCD process carried out in Ireland, which incorporated the input of Irish end-users and multidisciplinary experts throughout. OBJECTIVE: In this paper we report the results of a usability and user experience (UX) assessment of the WIISEL system in multiple countries and thus establish whether the UCD process carried out in Ireland produced positive usability and UX results outside of Ireland...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29906400/developing-a-3d-gestural-interface-for-anesthesia-related-human-computer-interaction-tasks-using-both-experts-and-novices
#10
Katherina A Jurewicz, David M Neyens, Ken Catchpole, Scott T Reeves
OBJECTIVE: The purpose of this research was to compare gesture-function mappings for experts and novices using a 3D, vision-based, gestural input system when exposed to the same context of anesthesia tasks in the operating room (OR). BACKGROUND: 3D, vision-based, gestural input systems can serve as a natural way to interact with computers and are potentially useful in sterile environments (e.g., ORs) to limit the spread of bacteria. Anesthesia providers' hands have been linked to bacterial transfer in the OR, but a gestural input system for anesthetic tasks has not been investigated...
June 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29905604/the-resurge-global-training-program-a-model-for-surgical-training-and-capacity-building-in-global-reconstructive-surgery
#11
Gloria R Sue, Woodrow C Covington, James Chang
BACKGROUND: A paradigm shift is underway in the world of humanitarian global surgery to address the large unmet need for reconstructive surgical services in low- and middle-income countries (LMICs). Here, we discuss the ReSurge Global Training Program (RGTP), a model for surgical training and capacity building in reconstructive surgery in the developing world. The program includes an online reconstructive surgery curriculum, visiting educator trips, expert reconstructive surgeon involvement, trainee competency tracking system, and identification of local outreach partners to provide safe reconstructive surgery to the neediest of patients in the developing world...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29905006/getting-it-right-core-outcome-sets-in-quality-improvement-research
#12
Brett D Einerson
Hospital systems, expert panels, and regulatory agencies developed quality metrics to monitor health system quality and safety. Dozens or hundreds of perinatal quality outcome measures are reported, but few are easily comparable. Bunch and colleagues (BJOG 2018) responded to the call by The CROWN Initiative (BJOG 2014;121:1181) to "develop core outcome sets using robust consensus methodology." Integrating the expertise of multiple stakeholders, the authors used Delphi methodology to develop a set of consensus-based core outcomes for monitoring the quality of care in English maternity units...
June 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29904380/antiphospholipid-syndrome-nephropathy-from-pathogenesis-to-treatment
#13
REVIEW
Maria G Tektonidou
Kidney damage is a well-recognized complication of the antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-associated APS. Kidney involvement in APS involves a variety of manifestations, such as renal artery thrombosis or stenosis, renal vein thrombosis, allograft loss due to thrombosis after kidney transplantation, and injury to the renal microvasculature, also known as APS nephropathy. Biopsy in patients with APS nephropathy includes acute thrombotic microangiopathy lesions and chronic intrarenal vascular lesions such as interlobular fibrous intimal hyperplasia, arterial and arteriolar recanalizing thrombosis, fibrous arterial occlusion, and focal cortical atrophy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29904370/vitamin-d-supplementation-guidelines-for-general-population-and-groups-at-risk-of-vitamin-d-deficiency-in-poland-recommendations-of-the-polish-society-of-pediatric-endocrinology-and-diabetes-and-the-expert-panel-with-participation-of-national-specialist-consultants
#14
REVIEW
Agnieszka Rusińska, Paweł Płudowski, Mieczysław Walczak, Maria K Borszewska-Kornacka, Artur Bossowski, Danuta Chlebna-Sokół, Justyna Czech-Kowalska, Anna Dobrzańska, Edward Franek, Ewa Helwich, Teresa Jackowska, Maria A Kalina, Jerzy Konstantynowicz, Janusz Książyk, Andrzej Lewiński, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Artur Mazur, Izabela Michałus, Jarosław Peregud-Pogorzelski, Hanna Romanowska, Marek Ruchała, Piotr Socha, Mieczysław Szalecki, Mirosław Wielgoś, Danuta Zwolińska, Arkadiusz Zygmunt
Introduction: Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professionals in Poland, an updated recommendation for the prevention, diagnosis and treatment of vitamin D deficiency. Methods: A systematic literature search examining the prevention and treatment strategies for vitamin D deficiency was conducted...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29904105/an-interdisciplinary-consensus-on-the-management-of-bone-metastases-from-renal-cell-carcinoma
#15
REVIEW
Viktor Grünwald, Berit Eberhardt, Axel Bex, Anne Flörcken, Thomas Gauler, Thorsten Derlin, Martin Panzica, Hans Roland Dürr, Knut Achim Grötz, Rachel H Giles, Christian von Falck, Anno Graser, Alexander Muacevic, Michael Staehler
Bone is a major site of haematogenous tumour cell spread in renal cell carcinoma (RCC), and most patients with RCC will develop painful and functionally disabling bone metastases at advanced disease stages. The prognosis of these patients is generally poor and the treatment is, therefore, aimed at palliation. However, RCC-associated bone metastases can be curable in select patients. Current data support a multimodal management strategy that includes wide resection of lesions, radiotherapy, systemic therapy, and other local treatment options, which can improve quality of life and survival...
June 14, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29903475/computerized-decision-support-for-beneficial-home-based-exercise-rehabilitation-in-patients-with-cardiovascular-disease
#16
Andreas Triantafyllidis, Dimitris Filos, Roselien Buys, Jomme Claes, Véronique Cornelissen, Evangelia Kouidi, Anargyros Chatzitofis, Dimitris Zarpalas, Petros Daras, Deirdre Walsh, Catherine Woods, Kieran Moran, Nicos Maglaveras, Ioanna Chouvarda
BACKGROUND: Exercise-based rehabilitation plays a key role in improving the health and quality of life of patients with Cardiovascular Disease (CVD). Home-based computer-assisted rehabilitation programs have the potential to facilitate and support physical activity interventions and improve health outcomes. OBJECTIVES: We present the development and evaluation of a computerized Decision Support System (DSS) for unsupervised exercise rehabilitation at home, aiming to show the feasibility and potential of such systems toward maximizing the benefits of rehabilitation programs...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29902386/hypofractionated-radiation-treatment-in-the-management-of-breast-cancer
#17
Apar Gupta, Nisha Ohri, Bruce G Haffty
The standard treatment for early-stage breast cancer is breast conservation therapy, consisting of breast conserving surgery followed by adjuvant radiation treatment (RT). Conventionally-fractionated whole breast irradiation (CF-WBI) has been the standard RT regimen, but recently shorter courses of hypofractionated whole breast irradiation (HF-WBI) have been advocated for patient convenience and reduction in healthcare costs and resources. Areas covered: This review covers the major randomized European and Canadian trials comparing HF-WBI to CF-WBI with long-term follow-up, as well as additional recently closed randomized trials that further seek to define the applicability of HF-WBI in clinical practice...
June 14, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29902093/strategies-for-improving-the-specificity-of-sirnas-for-enhanced-therapeutic-potential
#18
Aditya Kiran Gatta, Raghu Chandrashekhar Hariharapura, Nayanabhirama Udupa, Meka Sreenivasa Reddy, Venkata Rao Josyula
RNA interference has become a tool of choice in the development of drugs in various therapeutic areas of Post Transcriptional Gene Silencing (PTGS). The critical element in developing successful RNAi therapeutics lies in designing small interfering RNA (siRNA) using an efficient algorithm satisfying the designing criteria. Further, translation of siRNA from bench-side to bedside needs an efficient delivery system and/or chemical modification. Areas covered: This review emphasizes the importance of dicer, the criteria for efficient siRNA design, the currently available algorithms and strategies to overcome off-target effects, immune stimulatory effects and endosomal trap...
June 14, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29900388/the-availability-of-health-information-system-for-decision-making-with-evidence-based-medicine-approach-a-case-study-kermanshah-iran
#19
Ameneh Safari, Yahya Safari
Evidence-based medicine (EBM) is defining proper and wise use of the best evidence in clinical decision for patient׳s care. This study have done with the aim of evaluating health information system for decision-making with EBM approach in educational hospital of Kermanshah city. The statistical population include all the specialist and specialty, and also head nurses of educational hospitals in Kermanshah city. The data collected by researcher made questionnaire. The content validities of the questionnaire were confirmed by experts to complete the questions of the questionnaire...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29900248/two-datasets-of-defect-reports-labeled-by-a-crowd-of-annotators-of-unknown-reliability
#20
Jerónimo Hernández-González, Daniel Rodriguez, Iñaki Inza, Rachel Harrison, Jose A Lozano
Classifying software defects according to any defined taxonomy is not straightforward. In order to be used for automatizing the classification of software defects, two sets of defect reports were collected from public issue tracking systems from two different real domains. Due to the lack of a domain expert, the collected defects were categorized by a set of annotators of unknown reliability according to their impact from IBM's orthogonal defect classification taxonomy. Both datasets are prepared to solve the defect classification problem by means of techniques of the learning from crowds paradigm (Hernández-González et al...
June 2018: Data in Brief
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