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https://www.readbyqxmd.com/read/29444484/application-of-a-new-targeted-low-density-microarray-and-conventional-biomarkers-to-evaluate-the-health-status-of-marine-mussels-a-field-study-in-sardinian-coast-italy
#1
Susanna Sforzini, Caterina Oliveri, Andrea Orrù, Giannina Chessa, Beniamina Pacchioni, Caterina Millino, Awadhesh N Jha, Aldo Viarengo, Mohamed Banni
In the present study, we investigated the health status of marine mussels (Mytilus galloprovincialis) caged and deployed at three different sites on the Sardinian coastline characterized by different levels of contamination: Fornelli (F, the reference site), Cala Real (CR), and Porto Torres (PT). A new low density oligonucleotide microarray was used to investigate global gene expression in the digestive gland of mussels. Target genes were selected to cover most of the biological processes involved in the stress response in bivalve mollusks (e...
February 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29444331/validation-of-the-acr-eular-criteria-for-primary-sj%C3%A3-gren-s-syndrome-in-a-dutch-prospective-diagnostic-cohort
#2
Jolien F van Nimwegen, Martha S van Ginkel, Suzanne Arends, Erlin A Haacke, Bert van der Vegt, Nicole Sillevis Smitt-Kamminga, Fred K L Spijkervet, Frans G M Kroese, Alja J Stel, Elisabeth Brouwer, Arjan Vissink, Hendrika Bootsma
Objectives: To validate the ACR-EULAR classification criteria for primary SS (pSS), and compare them to the American-European Consensus Group (AECG) and ACR criteria in a Dutch prospective diagnostic cohort. Methods: Consecutive patients (n = 129) referred for suspicion of pSS underwent a multidisciplinary evaluation, including a labial and/or parotid gland biopsy. Patients with an incomplete work-up (n = 8) or associated systemic auto-immune disease (n = 7) were excluded...
February 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29442540/management-of-immune-related-adverse-events-in-patients-treated-with-immune-checkpoint-inhibitor-therapy-american-society-of-clinical-oncology-clinical-practice-guideline
#3
Julie R Brahmer, Christina Lacchetti, Bryan J Schneider, Michael B Atkins, Kelly J Brassil, Jeffrey M Caterino, Ian Chau, Marc S Ernstoff, Jennifer M Gardner, Pamela Ginex, Sigrun Hallmeyer, Jennifer Holter Chakrabarty, Natasha B Leighl, Jennifer S Mammen, David F McDermott, Aung Naing, Loretta J Nastoupil, Tanyanika Phillips, Laura D Porter, Igor Puzanov, Cristina A Reichner, Bianca D Santomasso, Carole Seigel, Alexander Spira, Maria E Suarez-Almazor, Yinghong Wang, Jeffrey S Weber, Jedd D Wolchok, John A Thompson
Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process...
February 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29442038/non-viral-gene-delivery-systems-hurdles-for-bench-to-bedside-transformation
#4
N A Helal, A Osami, A Helmy, T McDonald, L A Shaaban, M I Nounou
Biologist and Nobel Prize winner James Watson's quote, "We used to think that our fate was in our stars, but now we know that, in large measure, our fate is in our genes", represents the initial food for thought that revolutionized the way medications and active pharmaceutical ingredients are defined (Rocholl 1996). This fate engraved in the genetic material, as mentioned in Watson's quote, fueled a tremendous revolution wave in gene therapy. Gene therapy is a promising technology for treating genetic and acquired diseases by modulating the expression of a specific gene in the pathological cells...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441344/implementation-of-a-sustainable-training-system-for-emergency-in-vietnam
#5
REVIEW
Sunjoo Kang, Hyejin Seo, Binh Duy Ho, Phuong Thi Anh Nguyen
Purpose: This study analyzed the project outcomes to share lessons regarding the development of an emergency medicine education system in Vietnam. Methods: Retrospective evaluation was implemented using project outcome indicators. Results: A total of 13 training courses were administered, with the collaboration of international experts in Korea and Vietnam. A total of 23 kinds of emergency medicine education equipment were purchased, and a basic life support (BLS) and two advanced cardiac life support labs were remodeled to provide appropriate simulation training...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29441330/measurement-of-health-system-performance-at-district-level-a-study-protocol
#6
Atul Sharma, Shankar Prinja, Arun Kumar Aggarwal
Background: Limited efforts have been observed in low and middle income countries to undertake health system performance assessment at district level. Absence of a comprehensive data collection tool and lack of a standardised single summary measure defining overall performance are some of the main problems. Present study has been undertaken to develop a summary composite health system performance index at district level. Methods: A broad range of indicators covering all six domains as per building block framework were finalized by an expert panel...
December 13, 2017: Journal of Public Health Research
https://www.readbyqxmd.com/read/29440943/state-of-the-art-of-robotic-surgery-related-to-vision-brain-and-eye-applications-of-newly-available-devices
#7
REVIEW
Raffaele Nuzzi, Luca Brusasco
Background: Robot-assisted surgery has revolutionized many surgical subspecialties, mainly where procedures have to be performed in confined, difficult to visualize spaces. Despite advances in general surgery and neurosurgery, in vivo application of robotics to ocular surgery is still in its infancy, owing to the particular complexities of microsurgery. The use of robotic assistance and feedback guidance on surgical maneuvers could improve the technical performance of expert surgeons during the initial phase of the learning curve...
2018: Eye and Brain
https://www.readbyqxmd.com/read/29439843/development-and-reliability-of-the-rating-of-compensatory-movements-in-upper-limb-prosthesis-wearers-during-work-related-tasks
#8
Tallie M J van der Laan, Sietke G Postema, Michiel F Reneman, Raoul M Bongers, Corry K van der Sluis
STUDY DESIGN: Reliability study. INTRODUCTION: Quantifying compensatory movements during work-related tasks may help to prevent musculoskeletal complaints in individuals with upper limb absence. PURPOSE OF THE STUDY: (1) To develop a qualitative scoring system for rating compensatory shoulder and trunk movements in upper limb prosthesis wearers during the performance of functional capacity evaluation tests adjusted for use by 1-handed individuals (functional capacity evaluation-one handed [FCE-OH]); (2) to examine the interrater and intrarater reliability of the scoring system; and (3) to assess its feasibility...
February 10, 2018: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29439729/application-of-neural-networks-for-classification-of-patau-edwards-down-turner-and-klinefelter-syndrome-based-on-first-trimester-maternal-serum-screening-data-ultrasonographic-findings-and-patient-demographics
#9
Aida Catic, Lejla Gurbeta, Amina Kurtovic-Kozaric, Senad Mehmedbasic, Almir Badnjevic
BACKGROUND: The usage of Artificial Neural Networks (ANNs) for genome-enabled classifications and establishing genome-phenotype correlations have been investigated more extensively over the past few years. The reason for this is that ANNs are good approximates of complex functions, so classification can be performed without the need for explicitly defined input-output model. This engineering tool can be applied for optimization of existing methods for disease/syndrome classification. Cytogenetic and molecular analyses are the most frequent tests used in prenatal diagnostic for the early detection of Turner, Klinefelter, Patau, Edwards and Down syndrome...
February 13, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29439069/moving-towards-a-better-path-a-mixed-method-examination-of-china-s-reforms-to-remedy-medical-corruption-from-pharmaceutical-firms
#10
Jianwei Shi, Rui Liu, Hua Jiang, Chunxu Wang, Yue Xiao, Nana Liu, Zhaoxin Wang, Leiyu Shi
OBJECTIVES: Few studies have systematically examined the effects of the existing regulations for alleviating corruption in China. This study assesses the effectiveness of China's reforms to curb medical corruption. METHODS: We used mixed methods for the evaluation of existing countermeasures. First, qualitative informant interviews based on the Donabedian model were conducted to obtain experts' evaluation of various kinds of countermeasures. Second, using data from 'China Judgements Online', we analysed the trend of occurrence and the characteristics of the medical corruption cases in recent years to reflect the overall effects of these countermeasures in China...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438500/diffusion-radiomics-as-a-diagnostic-model-for-atypical-manifestation-of-primary-central-nervous-system-lymphoma-development-and-multicenter-external-validation
#11
Daesung Kang, Ji Eun Park, Young-Hoon Kim, Jeong Hoon Kim, Joo Young Oh, Jungyoun Kim, Yikyung Kim, Sung Tae Kim, Ho Sung Kim
Background: Radiomics is a rapidly growing field in neuro-oncology, but studies have been limited to conventional MRI and external validation is critically lacking. We evaluated technical feasibility, diagnostic performance, and generalizability of a diffusion radiomics model for identifying atypical primary central nervous system lymphoma (PCNSL) mimicking glioblastoma. Methods: Total 1618 radiomics features were extracted from diffusion and conventional MRI from 112 patients (training set, 70 glioblastomas and 42 PCNSLs)...
February 9, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29438494/artificial-intelligence-in-drug-combination-therapy
#12
Igor F Tsigelny
Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. Drug combination therapy has been an area of interest for a while, for example the classical work of Loewe devoted to the synergism of drugs was published in 1928-and it is still used in calculations for optimal drug combinations...
February 9, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29436806/d%C3%A3-veloppement-d-un-syst%C3%A3-me-de-gestion-de-la-performance-des-soins-dans-un-centre-hospitalier-universitaire-suisse
#13
Joachim Rapin, Danielle D Amour, Thierry Penseyres, Gabrielle Santos, Vincent Adatte, Isabelle Lehn, Cédric Mabire
Studies show high variability in the quality of care and a significant incidence of adverse events. The care management direction of a university hospital center (CHU) has developed a care performance measuring system. The aim of the article is to present the different development stages of this system. The authors used May's Normalization Process Theory, which focuses on factors influencing the engagement of individuals, groups, and organizations in sustaining change.The CHU's approach led to the following results : 1) reaching a consensus on performance concept and identifying five areas of performance, 2) selection of 12 priority indicators to assess performance, 3) measures development, 4) setting up the method of collecting information 5) creation of a mechanism for analyzing the results by care teams and 6) dissemination of results via dashboards...
February 2, 2018: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29436048/home-birth-integration-into-the-health-care-systems-of-eleven-international-jurisdictions
#14
Amanda Comeau, Eileen K Hutton, Julia Simioni, Ella Anvari, Megan Bowen, Samantha Kruegar, Elizabeth K Darling
BACKGROUND: The purpose of this study was to develop assessment criteria that could be used to examine the level of integration of home birth within larger health care systems in developed countries across 11 international jurisdictions. METHODS: An expert panel developed criteria and a definition to assess home birth integration within health care systems. We selected jurisdictions based on the publications that were eligible for inclusion in our systematic review and meta-analysis on planned place of birth...
February 13, 2018: Birth
https://www.readbyqxmd.com/read/29435754/eaes-classification-of-intraoperative-adverse-events-in-laparoscopic-surgery
#15
N K Francis, N J Curtis, J A Conti, J D Foster, H J Bonjer, G B Hanna
BACKGROUND: Surgical outcomes are traditionally evaluated by post-operative data such as histopathology and morbidity. Although these outcomes are reported using accepted systems, their ability to influence operative performance is limited by their retrospective application. Interest in direct measurement of intraoperative events is growing but no available systems applicable to routine practice exist. We aimed to develop a structured, practical method to report intraoperative adverse events enacted during minimal access surgical procedures...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435749/skills-in-minimally-invasive-and-open-surgery-show-limited-transferability-to-robotic-surgery-results-from-a-prospective-study
#16
Karl-Friedrich Kowalewski, Mona W Schmidt, Tanja Proctor, Moritz Pohl, Erica Wennberg, Emir Karadza, Philipp Romero, Hannes G Kenngott, Beat P Müller-Stich, Felix Nickel
BACKGROUND: There is limited evidence on the transferability of conventional laparoscopic and open surgical skills to robotic-assisted surgery. The primary aim of this study was to evaluate the transferability of expertise in conventional laparoscopy and open surgery to robotic-assisted surgery using the da Vinci Skills Simulator (dVSS). Secondary aims included evaluating the influence of individual participants' characteristics. METHODS: Participants performed four tasks on the dVSS: Peg Board 1 (PB), Pick and Place (PP), Thread the Rings (TR), and Suture Sponge 1 (SS)...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435330/the-japanese-clinical-practice-guidelines-for-management-of-sepsis-and-septic-shock-2016-j-sscg-2016
#17
Osamu Nishida, Hiroshi Ogura, Moritoki Egi, Seitaro Fujishima, Yoshiro Hayashi, Toshiaki Iba, Hitoshi Imaizumi, Shigeaki Inoue, Yasuyuki Kakihana, Joji Kotani, Shigeki Kushimoto, Yoshiki Masuda, Naoyuki Matsuda, Asako Matsushima, Taka-Aki Nakada, Satoshi Nakagawa, Shin Nunomiya, Tomohito Sadahiro, Nobuaki Shime, Tomoaki Yatabe, Yoshitaka Hara, Kei Hayashida, Yutaka Kondo, Yuka Sumi, Hideto Yasuda, Kazuyoshi Aoyama, Takeo Azuhata, Kent Doi, Matsuyuki Doi, Naoyuki Fujimura, Ryota Fuke, Tatsuma Fukuda, Koji Goto, Ryuichi Hasegawa, Satoru Hashimoto, Junji Hatakeyama, Mineji Hayakawa, Toru Hifumi, Naoki Higashibeppu, Katsuki Hirai, Tomoya Hirose, Kentaro Ide, Yasuo Kaizuka, Tomomichi Kan'o, Tatsuya Kawasaki, Hiromitsu Kuroda, Akihisa Matsuda, Shotaro Matsumoto, Masaharu Nagae, Mutsuo Onodera, Tetsu Ohnuma, Kiyohiro Oshima, Nobuyuki Saito, So Sakamoto, Masaaki Sakuraya, Mikio Sasano, Norio Sato, Atsushi Sawamura, Kentaro Shimizu, Kunihiro Shirai, Tetsuhiro Takei, Muneyuki Takeuchi, Kohei Takimoto, Takumi Taniguchi, Hiroomi Tatsumi, Ryosuke Tsuruta, Naoya Yama, Kazuma Yamakawa, Chizuru Yamashita, Kazuto Yamashita, Takeshi Yoshida, Hiroshi Tanaka, Shigeto Oda
Background and purpose: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] 10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29433630/an-exploration-of-the-experiences-of-australian-grey-nomads-travelling-with-chronic-conditions
#18
Kaara Ray B Calma, Elizabeth Halcomb, Moira Stephens
Internationally, the population is ageing and people are living well, longer. In Australia, extended travelling has gained popularity among older Grey Nomads due to time and opportunity post retirement. However, there is limited research available focusing on older Australians' health while travelling. This paper reports the qualitative phase of a larger mixed-method project that explores the experience of Australian Grey Nomads travelling with chronic conditions. Eight Grey Nomads participated in telephone interviews...
February 13, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29433593/education-practical-training-and-professional-development-for-public-health-practitioners-a-scoping-review-of-the-literature-and-insights-for-sustainable-food-system-capacity-building
#19
Jessica Wegener, Debbie Fong, Cecilia Rocha
OBJECTIVE: Noting the upstream positioning of sustainable food systems (SFS) to multiple global crises, the present review described examples of emerging and promising practices to support SFS-oriented education, practical training (PT) and continuing professional development (CPD) among trainees and public health practitioners (PHP). A secondary objective was to compile the evidence into practical considerations for educators, supervising practitioners and professional associations. DESIGN: A scoping review of the literature published between 2007 and 2017 was conducted in May 2017 using four databases: CINAHL, MEDLINE, Scopus and HSSA, along with bibliography hand-searching and expert consultation...
February 13, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29433508/research-priority-setting-reproductive-health-in-the-occupied-palestinian-territory
#20
Niveen M E Abu-Rmeileh, Rula Ghandour, Marina Tucktuck, Mohammad Obiedallah
BACKGROUND: Occupied Palestinian territory (oPt) is an authority with limited resources. Therefore, research conducted in such a setting should be prioritized and coordinated to follow a national research agenda. This study aims to produce a research agenda for reproductive health in the oPt that can be utilized by reproductive health stakeholders and contribute to the development of policy-based evidence to guide health practice. METHODS: In the current study, we followed research prioritization methods developed by the World Health Organization-Child Health and Nutrition Research Initiative...
February 13, 2018: Reproductive Health
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