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https://www.readbyqxmd.com/read/29243540/safety-assessment-of-plant-derived-fatty-acid-oils
#1
Christina L Burnett, Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 244 plant-derived fatty acid oils as used in cosmetics. Oils are used in a wide variety of cosmetic products for their skin conditioning, occlusive, emollient, and moisturizing properties. Since many of these oils are edible, and their systemic toxicity potential is low, the review focused on potential dermal effects. The Panel concluded that the 244 plant-derived fatty acid oils are safe as used in cosmetics.
November 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29243500/designing-medical-technology-for-resilience-integrating-health-economics-and-human-factors-approaches
#2
Simone Borsci, Ijeoma Uchegbu, Peter Buckle, Zhifang Ni, Simon Walne, George B Hanna
The slow adoption of innovation into healthcare calls into question the manner of evidence generation for medical technology. This paper identifies potential reasons for this including a lack of attention to human factors, poor evaluation of economic benefits, lack of understanding of the existing healthcare system and a failure to recognise the need to generate resilient products. Areas covered. Recognising a cross-disciplinary need to enhance evidence generation early in a technology's life cycle, the present paper proposes a new approach that integrates human factors and health economic evaluation as part of a wider systems approach to the design of technology...
December 15, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29243497/preventing-recurrent-events-in-survivors-of-acute-coronary-syndromes-in-australia-consensus-recommendations-using-the-delphi-process
#3
Christopher J Hammett, John Amerena, David Brieger, Andrew Sindone, Peter L Thompson, Matthew I Worthley, Philip E Aylward
OBJECTIVE: There remain substantial gaps in implementation of evidence-based care in patients with acute coronary syndromes (ACS) in Australia, which contribute to high recurrent event rates. Improved translation of evidence into effective action is a key health-care priority. We engaged cardiovascular experts from across Australia to develop straightforward, easily actionable recommendations on key medications to use following ACS. METHODS: An eight-person steering committee (SC) reviewed the published evidence and developed an initial set of statements to be developed into consensus recommendations using a modified Delphi technique...
December 15, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29242180/development-and-usability-evaluation-of-an-art-and-narrative-based-knowledge-translation-tool-for-parents-with-a-child-with-pediatric-chronic-pain-multi-method-study
#4
Kathy Reid, Lisa Hartling, Samina Ali, Anne Le, Allison Norris, Shannon D Scott
BACKGROUND: Chronic pain in childhood is increasingly being recognized as a significant clinical problem for children and their families. Previous research has identified that families want information about the causes of their child's chronic pain, treatment options, and effective strategies to help their child cope with the pain. Unfortunately, parents have reported that finding this information can be challenging. OBJECTIVE: The aim of this study was to actively work together with children attending a pediatric chronic pain clinic and their parents to develop, refine, and evaluate the usability of an art and narrative-based electronic book (e-book) for pediatric chronic pain...
December 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29241710/new-insights-into-the-gene-expression-associated-to-amyotrophic-lateral-sclerosis
#5
REVIEW
Daniela Recabarren-Leiva, Marcelo Alarcón
Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (40years, familial ALS or FALS) or with no family history (50years), but it is more common in people aged 60-69years. The cause of ALS is not known and it is not known yet why it affects some people and not others...
December 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29241641/the-systemic-sclerosis-questionnaire-sysq-validation-of-the-translation-of-the-original-german-version-into-spanish-and-its-relationship-to-the-disease-and-to-quality-of-life
#6
Maria Pilar Cruz-Domínguez, Moisés Casarrubias-Ramírez, Victor Gasca-Martínez, Cindy Maldonado García, Rosa Angélica Carranza-Muleiro, Gabriela Medina, Grettel García-Collinot, Daniel Hector Montes-Cortes
OBJECTIVE: Translation, transculturation and validity of the self-administered questionnaire for functionality (Systemic Sclerosis Questionnaires [SySQ]) for use in Spanish patients with systemic sclerosis and its relationship to the severity of the disease and to quality of life. PATIENTS AND METHODS: We conducted an observational analytical study to perform a cross-cultural validation of the self-administered questionnaire on functionality in scleroderma. The validity of the form and content was evaluated by an expert panel...
December 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29241390/public-health-impact-of-pneumococcal-conjugate-vaccine-infant-immunization-programs-assessment-of-invasive-pneumococcal-disease-burden-and-serotype-distribution
#7
Patricia Izurieta, Priti Bahety, Richard Adegbola, Christopher Clarke, Bernard Hoet
Introduction Pneumococcal conjugate vaccine (PCV) impact studies have reported substantial reductions in the incidence of invasive pneumococcal disease (IPD) after implementation of childhood PCV programs. Heterogeneity in surveillance systems, local epidemiology and PCV programs hampers comparisons between studies. We aimed to better understand the impact of childhood PCV programs on overall IPD and serotype distribution. Areas covered We analyzed the impact of PCV programs on the incidence of overall IPD, and the distribution of vaccine serotypes (VT) and non-vaccine serotypes (NVT) in children <5 years and adults ≥65 years old...
December 15, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29241386/modified-risk-associations-of-lipoproteins-and-apolipoproteins-by-chronic-low-grade-inflammation
#8
Altan Onat, Aysem Kaya, Evin Ademoglu
Lipoproteins and the apolipoproteins (apo) that they carry are major determinants of cardiovascular diseases (CVD) as well as metabolic, renal and inflammatory chronic disorders either directly or through mediation of risk factors. The notion that elevated low-density lipoprotein cholesterol (LDL-C) and apoB levels are related to the acquisition of CVD and, high-density lipoprotein cholesterol (HDL-C) and apoA-I indicate protection against CVD has been challenged in the past decade. Advanced age, adiposity, ethnicity or impaired glucose intolerance rendered autoimmune activation in an environment of pro-inflammatory state/oxidative stress and may disrupt the linear risk association between lipoproteins...
December 15, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29241377/current-and-future-immunotherapies-for-thyroid-cancer
#9
Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi
Cancer immunotherapies were approved in recent years, including immune checkpoint inhibitors. Experience with ipilimumab (CTLA-4 antagonist), nivolumab and pembrolizumab (PD-1 antagonists), and atezolizumab (PD-L1 antagonist) has shown that the impact on overall survival in cancer patients is paramount. Immune checkpoint inhibitors target the immune system and they can be applied across multiple cancers; the response rate is ranging from 20 to 40%. Many studies have shown that thyroid cancer (TC) cells produce cytokines and chemokines, inducing several tumor-promoting effects...
December 15, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29241365/gabapentin-for-the-treatment-of-alcohol-use-disorder
#10
Barbara J Mason, Susan Quello, Farhad Shadan
Alcohol misuse is the fifth leading risk factor for premature death and disability worldwide. Fewer than 10% of afflicted Americans receive pharmacological treatment for alcohol use disorder. Gabapentin is a calcium channel GABAergic modulator that is widely used for pain. Studies showing reduced drinking and decreased craving and alcohol-related disturbances in sleep and affect in the months following alcohol cessation suggest therapeutic potential for alcohol use disorder. Areas covered: Human laboratory and clinical studies assessing gabapentin for alcohol use disorder are reviewed...
December 15, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29240571/developing-the-clinical-nurse-leader-survey-instrument-a-modified-delphi-study
#11
Miriam Bender, Alice Avolio, Patricia Baker, James L Harris, Nancy Hilton, Lisle Hites, Linda Roussel, Bobbi Shirley, Patricia L Thomas, Marjory Williams
Clinical nurse leader (CNL)-integrated care delivery is an emerging nursing model, with growing adoption in diverse health systems. To generate a robust evidence base for this promising nursing model, it is necessary to measure CNL practice to explicitly link it to observed quality and safety outcome improvements. This study used a modified Delphi approach with an expert CNL panel to develop and test the face, content, and construct validity of the CNL Practice Survey instrument.
December 13, 2017: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29240533/investigation-of-perceptual-motor-behavior-across-the-expert-athlete-to-disabled-patient-skill-continuum-can-advance-theory-and-practical-application
#12
Sean Müller, Ann-Maree Vallence, Carolee Winstein
A framework is presented of how theoretical predictions can be tested across the expert athlete to disabled patient skill continuum. Common-coding theory is used as the exemplar to discuss sensory and motor system contributions to perceptual-motor behavior. Behavioral and neural studies investigating expert athletes and patients recovering from cerebral stroke are reviewed. They provide evidence of bi-directional contributions of visual and motor systems to perceptual-motor behavior. Majority of this research is focused on perceptual-motor performance or learning, with less on transfer...
December 14, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/29240457/urinary-peptidomics-in-kidney-disease-and-drug-research
#13
Magdalena Krochmal, Joost P Schanstra, Harald Mischak
Due to its close connection with the renal system, urine is considered a valuable source of information in kidney disease research. Peptidomics methods focus on the discovery of endogenous peptides, given their wide range of biological functions and diagnostic and therapeutic potential. Representing a non-invasive and sensitive method, technological prospects of urinary peptidomics should be evaluated in the context of drug discovery and research. Areas covered: This review describes urinary peptidomics with focus on its application in drug research in the field of kidney diseases...
December 14, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29239683/managing-cancer-care-through-service-delivery-networks-the-role-of-professional-collaboration-in-two-european-cancer-networks
#14
Joan Prades, Verdiana Morando, Valeria D Tozzi, Didier Verhoeven, Jose R Germà, Josep M Borras
Background The study examines two meso-strategic cancer networks, exploring to what extent collaboration can strengthen or hamper network effectiveness. Unlike macro-strategic networks, meso-strategic networks have no hierarchical governance structures nor are they institutionalised within healthcare services' delivery systems. This study aims to analyse the models of professional cooperation and the tools developed for managing clinical practice within two meso-strategic, European cancer networks. Methods Multiple case study design based on the comparative analysis of two cancer networks: Iridium, in Antwerp, Belgium and the Institut Català d'Oncologia in Catalonia, Spain...
January 1, 2017: Health Services Management Research
https://www.readbyqxmd.com/read/29239578/national-vaccination-program-a-success-story-of-public-health-and-economy
#15
Heini Salo, Terhi Kilpi
The savings in treatment costs generated by disease cases prevented by the national vaccination program exceed the costs of the vaccination program by at least 60 million euros. In addition, other costs due to contracting the illness are avoided. Vaccinations serve the purpose of both increasing well-being and releasing resources for other uses. Financial support of vaccinations through the health insurance system would be costly and targetted to those with the ability to pay. Public funds should be directed to the development of a vaccination program...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239190/-comparison-of-recist-1-1-and-irecist-for-response-evaluation-in-solid-tumours
#16
Š Houdek, T Büchler, E Kindlová
BACKGROUND: Immunotherapy is a relatively new and developing modality in oncological treatment, which may significantly improve treatment results for some patients with malignant tumors. With the increasing number of clinical trials, the demand for a suitable tool to assess and compare treatment responses is growing. Currently, the most common response assessment system for solid tumors is RECIST (response Evaluation Criteria in Solid Tumors) version 1.1. However, in immuno-oncology, a small percentage of patients manifest a new response pattern termed pseudoprogression, in which, after the initial increase in tumor burden or after the discovery of new lesions, a response or at least a prolonged stabilization of the disease can occur...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29238499/exploring-perceptions-of-policymakers-about-main-strategies-to-enhance-fertility-rate-a-qualitative-study-in-iran
#17
Ali Akbar Haghdoost, Roya Safari-Faramani, Mohammad Reza Baneshi, Reza Dehnavieh, Mahlegha Dehghan
Background: Total fertility rate in Iran has declined unprecedentedly over the past thirty years. However, debating on proper strategies to increase fertility is still a matter of discussion among experts. Objective: To explain the main strategies to increase fertility from the viewpoints of the policy makers. Methods: This is a qualitative study using content analysis. Purposeful sampling approach was used to gather data. The data were collected via semi-structured interviews...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238346/generating-a-tolerogenic-cell-therapy-knowledge-graph-from-literature
#18
Andre Lamurias, João D Ferreira, Luka A Clarke, Francisco M Couto
Tolerogenic cell therapies provide an alternative to conventional immunosuppressive treatments of autoimmune disease and address, among other goals, the rejection of organ or stem cell transplants. Since various methodologies can be followed to develop tolerogenic therapies, it is important to be aware and up to date on all available studies that may be relevant to their improvement. Recently, knowledge graphs have been proposed to link various sources of information, using text mining techniques. Knowledge graphs facilitate the automatic retrieval of information about the topics represented in the graph...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29238326/a-probabilistic-decision-making-scoring-system-for-quality-and-safety-management-in-alore%C3%A3-a-de-m%C3%A3-laga-table-olive-processing
#19
Miguel Á Ruiz Bellido, Antonio Valero, Eduardo Medina Pradas, Verónica Romero Gil, Francisco Rodríguez-Gómez, Guiomar D Posada-Izquierdo, Francisco Rincón, Aricia Possas, Rosa M García-Gimeno, Francisco N Arroyo-López
Table olives are one of the most representatives and consumed fermented vegetables in Mediterranean countries. However, there is an evident lack of standardization of production processes and HACCP systems thus implying the need of establishing decision-making tools allowing their commercialization and shelf-life extension. The present work aims at developing a decision-making scoring system by means of a probabilistic assessment to standardize production process of Aloreña de Málaga table olives based on the identification of potential hazards or deficiencies in hygienic processes for the subsequent implementation of corrective measures...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#20
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
December 13, 2017: Neurology
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