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https://www.readbyqxmd.com/read/28549455/inter-act-prevention-of-pregnancy-complications-through-an-e-health-driven-interpregnancy-lifestyle-intervention-study-protocol-of-a-multicentre-randomised-controlled-trial
#1
Annick Bogaerts, Lieveke Ameye, Margriet Bijlholt, Kelly Amuli, Dorine Heynickx, Roland Devlieger
BACKGROUND: Excessive maternal pre-pregnancy and gestational weight gain are related to pregnancy- and birth outcomes. The interpregnancy time window offers a unique opportunity to intervene in order to acquire a healthy lifestyle before the start of a new pregnancy. METHODS: INTER-ACT is an e-health driven multicentre randomised controlled intervention trial targeting women at high risk of pregnancy- and birth related complications. Eligible women are recruited for the study at day 2 or 3 postpartum...
May 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28547271/interview-based-versus-self-reported-anal-incontinence-using-st-mark-s-incontinence-score
#2
Hege Hølmo Johannessen, Stig Norderval, Arvid Stordahl, Ragnhild Sørum Falk, Arne Wibe
INTRODUCTION AND HYPOTHESIS: St Mark's incontinence score (SMIS) was originally designed and validated for use in an interview setting (iSMIS), and there is conflicting evidence for the validity of the self-administered SMIS (sSMIS). Our objective was to compare self-administered and interview-based reports of anal incontinence (AI) symptoms. METHODS: A total of 147 women reported symptoms of AI on a sSMIS before inclusion in a clinical study investigating the effect of conservative treatment for AI 1 year after delivery...
May 25, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28546563/microbiota-in-t-cell-homeostasis-and-inflammatory-diseases
#3
REVIEW
Naeun Lee, Wan-Uk Kim
The etiology of disease pathogenesis can be largely explained by genetic variations and several types of environmental factors. In genetically disease-susceptible individuals, subsequent environmental triggers may induce disease development. The human body is colonized by complex commensal microbes that have co-evolved with the host immune system. With the adaptation to modern lifestyles, its composition has changed depending on host genetics, changes in diet, overuse of antibiotics against infection and elimination of natural enemies through the strengthening of sanitation...
May 26, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28546086/physical-activity-and-cardiovascular-aging-physiological-and-molecular-insights
#4
REVIEW
Djordje G Jakovljevic
Aging is associated with significant changes in both cardiac and vascular structure and function that lower the threshold for clinical signs and symptoms, making older people more susceptible to cardiovascular diseases, morbidity and mortality. Understanding of age-related cardiovascular changes is necessary for effective and efficient prevention and treatment of cardiovascular disease in older people. Cardiac aging is associated with left ventricular remodelling marked by increased mass-to-volume ratio and accompanied by systolic and diastolic myocardial dysfunction, and reduced sensitivity to sympathetic stimuli that compromises myocardial contractility and pumping ability in older people...
May 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28545937/treatment-of-nafld-with-diet-physical-activity-and-exercise
#5
REVIEW
Manuel Romero-Gómez, Shira Zelber-Sagi, Michael Trenell
Lifestyle intervention can be useful across all the spectrum of NAFLD patients. Losing weight decreases cardiovascular / diabetes risk and also regresses liver disease. Weight reductions of ≥ 10% are required for inducing near universal NASH resolution or fibrosis improvement by at least one stage. However, modest weight losses (>5%) also produce important benefits on NAS and its components. In addition, to improve the success of this intervention we need to explore, beyond total calories and type of weight loss diet, the role of micro and macronutrients, evidence-based benefits of physical activity and exercise and finally supporting these modifications through established behaviour change models and techniques...
May 22, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28545514/a-coordinated-pcp-cardiologist-telemedicine-model-pctm-in-china-s-community-hypertension-care-study-protocol-for-a-randomized-controlled-trial
#6
Lei Xu, Wei-Yi Fang, Fu Zhu, Hong-Guang Zhang, Kai Liu
BACKGROUND: Hypertension is a major risk factor for cardiovascular disease, and its control rate has remained low worldwide. Studies have found that telemonitoring blood pressure (BP) helped control hypertension in randomized controlled trials. However, little is known about its effect in a structured primary care model in which primary care physicians (PCPs) are partnering with cardiology specialists in electronic healthcare data sharing and medical interventions. This study aims to identify the effects of a coordinated PCP-cardiologist model that applies telemedicine tools to facilitate community hypertension control in China...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28545104/pkng-senses-amino-acid-availability-to-control-metabolism-and-virulence-of-mycobacterium-tuberculosis
#7
Barbara Rieck, Giulia Degiacomi, Michael Zimmermann, Alessandro Cascioferro, Francesca Boldrin, Natalie R Lazar-Adler, Andrew R Bottrill, Fabien le Chevalier, Wafa Frigui, Marco Bellinzoni, María-Natalia Lisa, Pedro M Alzari, Liem Nguyen, Roland Brosch, Uwe Sauer, Riccardo Manganelli, Helen M O'Hare
Sensing and response to changes in nutrient availability are essential for the lifestyle of environmental and pathogenic bacteria. Serine/threonine protein kinase G (PknG) is required for virulence of the human pathogen Mycobacterium tuberculosis, and its putative substrate GarA regulates the tricarboxylic acid cycle in M. tuberculosis and other Actinobacteria by protein-protein binding. We sought to understand the stimuli that lead to phosphorylation of GarA, and the roles of this regulatory system in pathogenic and non-pathogenic bacteria...
May 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28545089/the-dynamic-behaviour-of-metabolic-syndrome-and-its-components-in-an-eight-year-population-based-cohort-from-the-mediterranean
#8
Maria A Barceló, Antonio Rodríguez-Poncelas, Marc Saez, Gabriel Coll-de-Tuero
BACKGROUND: The significant rise in the prevalence of obesity coincides with the considerable increase in the prevalence of metabolic syndrome (MS) currently being observed worldwide. The components of MS are not static and their dynamics, such as the order of their occurrence, or the time of exposure to them are, as yet, unknown but could well be clinically relevant. Our objective was to study the dynamic behaviour of MS and its components in a large population-based cohort from a Mediterranean region...
2017: PloS One
https://www.readbyqxmd.com/read/28544769/serum-biomarkers-can-predict-a-change-in-liver-fibrosis-one-year-after-lifestyle-intervention-for-biopsy-proven-nash
#9
Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Scott L Friedman, Bienvenido Gra-Oramas, Licet Gonzalez-Fabian, Sacha Lazo-Del Vallin, Moises Diago, Leon A Adams
BACKGROUND & AIMS: The dynamic response of serum fibrosis biomarkers to histological changes within the liver following lifestyle intervention (LI) is unknown. We explored relationships between changes in serum biomarkers and liver fibrosis in NASH patients undergoing LI. METHODS: Paired liver biopsies were performed in 261 NASH patients to assess fibrosis change after 1 year of LI. We explored the utility of serum fibrosis markers to predict changes in hepatic fibrosis and developed and internally validated a model for predicting fibrosis improvement in patients with baseline fibrosis...
May 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28544764/the-effectiveness-of-interventions-to-treat-hypothalamic-obesity-in-survivors-of-childhood-brain-tumours-a-systematic-review
#10
REVIEW
K-W Wang, R Chau, A Fleming, L Banfield, S K Singh, D L Johnston, S M Zelcer, S R Rassekh, S Burrow, M Valencia, R J de Souza, L Thabane, M C Samaan
BACKGROUND: Survivors of childhood brain tumours (SCBT) are at risk of type 2 diabetes and cardiovascular diseases. Obesity is a major driver of cardiometabolic diseases in the general population, and interventions that tackle obesity may lower the risk of these chronic diseases. The goal of this systematic review was to summarize current evidence for the presence of interventions to manage obesity, including hypothalamic obesity, in SCBT. METHODS: The primary outcome of this review was the body mass index z-score change from baseline to the end of the intervention and/or follow-up...
May 22, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28544465/correlates-of-nocturia-and-relationships-of-nocturia-with-sleep-quality-and-glycemic-control-in-women-with-type-2-diabetes
#11
Chun-Jen Chang, Dee Pei, Chien-Chih Wu, Mary H Palmer, Ching-Chieh Su, Shu-Fen Kuo, Yuan-Mei Liao
PURPOSES: To explore correlates of nocturia, compare sleep quality and glycemic control for women with and without nocturia, and examine relationships of nocturia with sleep quality and glycemic control in women with diabetes. DESIGN: This study was a cross-sectional, correlational study with data collected from 275 women with type 2 diabetes. METHODS: Data were collected using a structured questionnaire. Multivariate logistic regression analyses were used to identify correlates...
May 23, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28544174/a-qualitative-study-of-younger-men-s-experience-of-heart-attack-myocardial-infarction
#12
Christopher J Merritt, Nicole de Zoysa, Jane M Hutton
OBJECTIVES: The effects of heart attack, or myocardial infarction (MI), across psychosocial domains may be particularly acute in younger adults, for whom serious health events are non-normative. MI morbidity is declining in Western countries, but in England MI numbers have plateaued for the under-45 cohort, where approximately 90% of patients are male. Qualitative research on younger adults' experience of MI is limited, and no study has sampled exclusively under-45s. This study aimed to understand how a sample of men under 45 adjusted to and made sense of MI...
May 24, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28542503/biofilm-microenvironment-induces-a-widespread-adaptive-amino-acid-fermentation-pathway-conferring-strong-fitness-advantage-in-escherichia-coli
#13
Sylvie Létoffé, Sabina Chalabaev, José Dugay, Franziska Stressmann, Bianca Audrain, Jean-Charles Portais, Fabien Letisse, Jean-Marc Ghigo
Bacterial metabolism has been studied primarily in liquid cultures, and exploration of other natural growth conditions may reveal new aspects of bacterial biology. Here, we investigate metabolic changes occurring when Escherichia coli grows as surface-attached biofilms, a common but still poorly characterized bacterial lifestyle. We show that E. coli adapts to hypoxic conditions prevailing within biofilms by reducing the amino acid threonine into 1-propanol, an important industrial commodity not known to be naturally produced by Enterobacteriaceae...
May 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28542375/human-plasma-metabolomics-in-age-related-macular-degeneration-amd-using-nuclear-magnetic-resonance-spectroscopy
#14
Inês Laíns, Daniela Duarte, António S Barros, Ana Sofia Martins, João Gil, John B Miller, Marco Marques, Tânia Mesquita, Ivana K Kim, Maria da Luz Cachulo, Demetrios Vavvas, Isabel M Carreira, Joaquim N Murta, Rufino Silva, Joan W Miller, Deeba Husain, Ana M Gil
PURPOSE: To differentiate the plasma metabolomic profile of patients with age related macular degeneration (AMD) from that of controls, by Nuclear Magnetic Resonance (NMR) spectroscopy. METHODS: Two cohorts (total of 396 subjects) representative of central Portugal and Boston, USA phenotypes were studied. For each cohort, subjects were grouped according to AMD stage (early, intermediate and late). Multivariate analysis of plasma NMR spectra was performed, followed by signal integration and univariate analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28541466/initial-level-and-rate-of-change-in-grip-strength-predict-all-cause-mortality-in-very-old-adults
#15
Antoneta Granic, Karen Davies, Carol Jagger, Richard M Dodds, Thomas B L Kirkwood, Avan A Sayer
Objective: to investigate the associations between initial level and rate of change in grip strength (GS) and all-cause mortality in very old adults (≥85 years) over a 9.6-year follow-up. Methods: prospective mortality data from 845 participants in the Newcastle 85+ Study were analysed for survival in relation to GS (kg, baseline and 5-year mean change) using Cox proportional hazards models. Results: during the follow-up, 636 (75.3%) participants died...
May 25, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28541436/changes-in-sleep-duration-during-transition-to-statutory-retirement-a-longitudinal-cohort-study
#16
Saana Myllyntausta, Paula Salo, Erkki Kronholm, Ville Aalto, Mika Kivimäki, Jussi Vahtera, Sari Stenholm
Study Objectives: This study examined whether sleep duration changes during the transition from full-time work to statutory retirement and, if this were the case, which pre-retirement factors, including sociodemographic, work, lifestyle and health factors, predict these changes. Methods: Data from repeated surveys of the Finnish Public Sector study, linked to records of retirement, were used. The study population consisted of 5,785 participants who retired on a statutory basis in 2000-2011 and who had responded to surveys on sleep duration at least once immediately before and after their retirement (mean number of repeat study waves 3...
May 24, 2017: Sleep
https://www.readbyqxmd.com/read/28540101/health-status-and-lifestyle-habits-of-us-medical-students-a-longitudinal-study
#17
B J Brehm, S S Summer, J C Khoury, A T Filak, M A Lieberman, J E Heubi
BACKGROUND: Evidence shows that physicians and medical students who engage in healthy lifestyle habits are more likely to counsel patients about such behaviors. Yet medical school is a challenging time that may bring about undesired changes to health and lifestyle habits. AIMS: This study assessed changes in students' health and lifestyle behaviors during medical school. SUBJECTS AND METHODS: In a longitudinal study, students were assessed at both the beginning and end of medical school...
November 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28539960/physical-education-in-a-thermal-spa-resort-to-maintain-an-active-lifestyle-at-home-a-one-year-self-controlled-follow-up-pilot-study
#18
Julien Maitre, Benjamin Guinhouya, Nicole Darrieutort, Thierry Paillard
The self-controlled follow-up pilot study was set up to examine the maintenance of engagement in physical activity by a group of older adults in a thermal spa resort, as a consequence of the inclusion of additional physical education sessions within their usual care offers. A cohort of 42 participants (70.4 ± 4.5 years) underwent three weeks of thermal treatment with additional physical education (PE) sessions. Measurements were established during the intervention in 2 periods (baseline and final thermal treatment evaluation) and 4 periods of measurements in the follow-up (+15 days, +2 months, +6 months, and +1 year)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28539179/changes-in-use-of-time-across-retirement-a-longitudinal-study
#19
Judy Sprod, Timothy Olds, Wendy Brown, Nicola Burton, Jannique van Uffelen, Katia Ferrar, Carol Maher
OBJECTIVES: This study aimed to investigate how daily use of time changes across the retirement transition and how these changes may differ according to socio-demographic characteristics. STUDY DESIGN: This longitudinal cohort study was based on interviews with 124 people at pre-retirement and at three, six and 12 months after retirement. MAIN OUTCOME MEASURES: The Multimedia Activity Recall for Children and Adults (MARCA), a computer-assisted telephone interview, measured use of time...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28538698/diet-hypotheses-in-light-of-the-microbiota-revolution-new-perspectives
#20
REVIEW
Tomasz P Wypych, Benjamin J Marsland
From an evolutionary standpoint, allergy has only recently emerged as a significant health problem. Various hypotheses were proposed to explain this, but they all indicated the importance of rapid lifestyle changes, which occurred in industrialized countries in the last few decades. In this review, we discuss evidence from epidemiological and experimental studies that indicate changes in dietary habits may have played an important role in this phenomenon. Based on the example of dietary fiber, we discuss molecular mechanisms behind this and point towards the importance of diet-induced changes in the microbiota...
May 24, 2017: Nutrients
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