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https://www.readbyqxmd.com/read/29306244/tnf-alpha-863c-a-promoter-and-tnfrii-196t-g-exonic-variationsmay-be-risk-factors-for-juvenile-idiopathic-arthritis
#1
Bahadır Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven
Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients. Materials and methods: We analyzed eight polymorphisms, TNF-alpha-863 C > A, TNFRII 196 T > G, IL2-631 G > A, IL13-1112 C > T, CCR2 190 G > A, CCR5delta32, CTLA4-1661 A > G, and PTPN22 1858 C > T, in 76 patients with JIA and in 80 healthy controls, who were of a similar age and same sex...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29304038/tumor-targeted-delivery-of-doxorubicin-in-malignant-peripheral-nerve-sheath-tumors
#2
A B Madhankumar, Oliver D Mrowczynski, Becky Slagle-Webb, Vagisha Ravi, Alexandre J Bourcier, Russell Payne, Kimberly S Harbaugh, Elias Rizk, James R Connor
Peripheral nerve sheath tumors are benign tumors that have the potential to transform into malignant peripheral nerve sheath tumors (MPNSTs). Interleukin-13 receptor alpha 2 (IL13Rα2) is a cancer associated receptor expressed in glioblastoma and other invasive cancers. We analyzed IL13Rα2 expression in several MPNST cell lines including the STS26T cell line, as well as in several peripheral nerve sheath tumors to utilize the IL13Rα2 receptor as a target for therapy. In our studies, we demonstrated the selective expression of IL13Rα2 in several peripheral nerve sheath tumors by immunohistochemistry (IHC) and immunoblots...
2018: PloS One
https://www.readbyqxmd.com/read/29248492/r-loops-cause-genomic-instability-in-wiskott-aldrich-syndrome-thelper-lymphocytes
#3
Koustav Sarkar, Seong-Su Han, Kuo-Kwang Wen, Hans D Ochs, Loïc Dupré, Michael M Seidman, Yatin M Vyas
BACKGROUND: Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT), and X-linked neutropenia (XLN), caused by WAS mutations affecting WASp expression or activity, manifest in immunodeficiency, autoimmunity, genomic-instability, and lymphoid-cancer. WASp supports filamentous-actin formation in the cytoplasm and gene-transcription in the nucleus. Although the genetic basis for XLT/WAS has been clarified, the relationships between mutant forms of WASp and the diverse features of these disorders remain ill-defined...
December 14, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29232822/microglia-m2a-polarization-as-potential-link-between-food-allergy-and-autism-spectrum-disorders
#4
REVIEW
Hans O Kalkman, Dominik Feuerbach
Atopic diseases are frequently co-morbid with autism spectrum disorders (ASD). Allergic responses are associated with an activation of mast cells, innate lymphoid cells, and Th2 cells. These cells produce type-2 cytokines (IL4 and IL13), which stimulate microglia and macrophages to adopt a phenotype referred to as 'alternative activation' or 'M2A'. M2A-polarized macrophages and microglia play a physiological role in tissue repair by secreting growth factors such as brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1...
December 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29199960/update-on-the-genetic-basis-of-drug-hypersensitivity-reactions
#5
REVIEW
R Jurado-Escobar, J R Perkins, E García-Martín, M Isidoro-García, I Doña, M J Torres, J A Cornejo-García
Drug hypersensitivity reactions (DHRs) are unpredictable, complex responses to medicines in predisposed individuals. They represent a major health problem owing to the number of patients affected and the severity of the clinical conditions they can induce. In addition to environmental factors, the underlying mechanisms of DHRs are also influenced by genetic factors, although considerable gaps remain in our knowledge. Therefore, further study of the genetics of DHRs is necessary to shed light on their underlying mechanisms...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29188369/immune-modulation-of-th1-th2-and-t-reg-transcriptional-factors-differing-from-cytokine-levels-in-schistosoma-japonicum-infection
#6
Amel Farwa, Chao He, Longfei Xia, Hong Zhou
In spite of long-term integrated control programs for Schistosoma japonicum infection in China, the infection is still persistent due to its zoonotic transmission and disease severity which further complicate its control. Th1, Th2, and T-reg cells are involved in S. japonicum immunity; however, their exact roles in immunopathology of this infection are still questionable. Therefore, the monitoring of these T cell subsets' immune responses during a primary infection of S. japonicum at both transcriptional (mRNA) and protein (cytokines) levels would be essential to point out...
November 29, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29183288/arginase-1-deletion-in-myeloid-cells-affects-the-inflammatory-response-in-allergic-asthma-but-not-lung-mechanics-in-female-mice
#7
Roy H E Cloots, Selvakumari Sankaranarayanan, Matthew E Poynter, Els Terwindt, Paul van Dijk, Wouter H Lamers, S Eleonore Köhler
BACKGROUND: (Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis. We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) and lung inflammation in female mice with ovalbumin (OVA)-induced allergic asthma. METHODS: Arg1 was ablated in the lung by crossing Arg1 fl/fl and Tie2Cre tg/- mice. OVA sensitization and challenge were conducted, and AHR to methacholine was determined using the Flexivent system...
November 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29155876/docking-analysis-and-the-possibility-of-prediction-efficacy-for-an-anti-il-13-biopharmaceutical-treatment-with-tralokinumab-and-lebrikizumab-for-bronchial-asthma
#8
Yutaka Nakamura, Aki Sugano, Mika Ohta, Yutaka Takaoka
Interleukin-13 (IL-13) is associated with allergic airway inflammation and airway remodeling. Our group found a variant with a single nucleotide polymorphism in the IL13 gene at position +2044G>A (rs20541) that was expected to result in the non-conservative replacement of a positively charged arginine (R) with a neutral glutamine (Q) at position 144. IL-13Q144 was associated with augmented allergic airway inflammation and bronchial asthma remodeling. There is some indication that anti-IL-13 monoclonal antibodies can demonstrate a positive effect on the clinical course of refractory asthmatic patients...
2017: PloS One
https://www.readbyqxmd.com/read/29132961/experimental-asthma-persists-in-il-33-receptor-knockout-mice-because-of-the-emergence-of-thymic-stromal-lymphopoietin-driven-il-9-and-il-13-type-2-innate-lymphoid-cell-subpopulations
#9
Mukesh Verma, Sucai Liu, Lidia Michalec, Anand Sripada, Magdalena M Gorska, Rafeul Alam
BACKGROUND: IL-33 plays an important role in the development of experimental asthma. OBJECTIVE: We sought to study the role of the IL-33 receptor suppressor of tumorigenicity 2 (ST2) in the persistence of asthma in a mouse model. METHODS: We studied allergen-induced experimental asthma in ST2 knockout (KO) and wild-type control mice. We measured airway hyperresponsiveness by using flexiVent; inflammatory indices by using ELISA, histology, and real-time PCR; and type 2 innate lymphoid cells (ILC2s) in lung single-cell preparations by using flow cytometry...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29112724/severe-influenza-is-characterized-by-prolonged-immune-activation-results-from-the-shivers-cohort-study
#10
Sook-San Wong, Christine M Oshansky, Xi-Zhi J Guo, Jacqui Ralston, Timothy Wood, Gary Reynolds, Ruth Seeds, Claire Newbern, Ben Waite, Marc-Alain Widdowson, Q Sue Huang, Richard J Webby, Paul G Thomas
Background: The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of non-hospitalized individuals with influenza-like illness (ILI). Methods: Peripheral blood lymphocytes were collected from ILI (N=27) and SARI-patients (N=27) at time of enrollment and then two weeks later. Innate and adaptive cellular immune responses were assessed by flow-cytometry and serum cytokines were assessed by bead-based assay...
November 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29081776/innate-lymphoid-cells-in-intestinal-inflammation
#11
REVIEW
Alessandra Geremia, Carolina V Arancibia-Cárcamo
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals. Results from animal models of colitis and human studies indicate a role for innate lymphoid cells (ILC) in the pathogenesis of chronic intestinal inflammation in IBD. ILC are a population of lymphocytes that are enriched at mucosal sites, where they play a protective role against pathogens including extracellular bacteria, helminthes, and viruses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29063440/the-future-of-atopic-dermatitis-treatment
#12
Nupur Patel, Lindsay C Strowd
In recent years, there has been a growing movement towards the use of targeted therapies in treating of atopic dermatitis (AD), parallel to that which has occurred in psoriasis. Among the systemic medications being studied are subcutaneous or intravenously administered biologic drugs targeting specific molecules such as IL4, IL13, IL17, and IgE. Non-biologic oral therapies are also being developed for AD and include small molecule drugs targeting phosphodiesterase type IV (PDE4) inhibition or Janus Kinase (JAK) inhibition...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29053126/-effect-of-cytokine-genes-and-season-of-birth-on-personality
#13
M V Alfimova, V E Golimbet, G I Korovaitseva, T V Lezheiko, N V Kondrat'ev, M V Gabaeva
AIM: To evaluate the interaction effects of season of birth and immune system genes on the personality traits 'Novelty seeking' (NS) and 'Self-directedness' (SD). Based on results on an influence of the immune system on the brain processes, the authors hypothesized that the interaction of immune system genes and season of birth, which is relevant for immune phenotype, can contribute to the development of personality traits. MATERIAL AND METHODS: NS and SD were measured in 336 healthy volunteers, aged from 16 to 67 years, using the Temperament and Character Inventory (TCI-125)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29051761/predicting-risk-of-infection-in-patients-with-newly-diagnosed-multiple-myeloma-utility-of-immune-profiling
#14
Benjamin W Teh, Simon J Harrison, Cody Charles Allison, Monica A Slavin, Tim Spelman, Leon J Worth, Karin A Thursky, David Ritchie, Marc Pellegrini
BACKGROUND: A translational study in patients with myeloma to determine the utility of immune profiling to predict infection risk in patients with hematological malignancy was conducted. METHODS: Baseline, end of induction, and maintenance peripheral blood mononuclear cells from 40 patients were evaluated. Immune cell populations and cytokines released from 1 × 10(6) cells/ml cultured in the presence of a panel of stimuli (cytomegalovirus, influenza, S. pneumoniae, phorbol myristate acetate/ionomycin) and in media alone were quantified...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28947144/cytokine-gene-polymorphisms-associated-with-various-domains-of-quality-of-life-in-women-with-breast-cancer
#15
Kimberly Alexander, Yvette P Conley, Jon D Levine, Bruce A Cooper, Steven M Paul, Judy Mastick, Claudia West, Christine Miaskowski
CONTEXT: Little is known about the phenotypic and molecular characteristics associated with various domains of quality of life (QOL) in women following breast cancer surgery. OBJECTIVES: In a sample of women with breast cancer (n= 398), purposes were: to identify latent classes with distinct trajectories of QOL from prior to through six months following surgery and to evaluate for differences in demographic and clinical characteristics, as well as for polymorphisms in cytokine genes, between these latent classes...
September 22, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28930110/cytokine-single-nucleotide-polymorphisms-and-risk-of-non-small-cell-lung-cancer
#16
Cristina Pérez-Ramírez, Ahmed Alnatsha, Marisa Cañadas-Garre, Eduardo Villar, Javier Valdivia-Bautista, María J Faus-Dáder, Miguel Á Calleja-Hernández
OBJECTIVE: Lung cancer, particularly the non-small-cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death worldwide. Several functional polymorphisms in inflammatory cytokine genes, such as IL1B, IL6, IL12A, IL13 and IL16, have been associated with the risk of NSCLC. The aim of this study was to evaluate the association between ILs gene polymorphisms and the risk of developing NSCLC. PARTICIPANTS AND METHODS: A retrospective case-control study was carried out, including 174 NSCLC cases and 298 controls of Spanish origin...
September 18, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28915667/assessment-of-near-infrared-fluorophores-to-study-the-biodistribution-and-tumor-targeting-of-an-il13-receptor-%C3%AE-2-antibody-by-fluorescence-molecular-tomography
#17
Parul Gupta, Jo-Ann Wentland, Mauricio Leal, Dangshe Ma, Rachel Roach, Antonio Esparza, Lindsay King, Mary E Spilker, Cedo Bagi, Christopher T Winkelmann, Anand Giddabasappa
Non-invasive imaging using radiolabels is a common technique used to study the biodistribution of biologics. Due to the limited shelf-life of radiolabels and the requirements of specialized labs, non-invasive optical imaging is an attractive alternative for preclinical studies. Previously, we demonstrated the utility of fluorescence molecular tomography (FMT) an optical imaging modality in evaluating the biodistribution of antibody-drug conjugates. As FMT is a relatively new technology, few fluorophores have been validated for in vivo imaging...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912468/cytokine-based-predictive-models-to-estimate-the-probability-of-chronic-periodontitis-development-of-diagnostic-nomograms
#18
I Tomás, N Arias-Bujanda, M Alonso-Sampedro, M A Casares-de-Cal, C Sánchez-Sellero, D Suárez-Quintanilla, C Balsa-Castro
Although a distinct cytokine profile has been described in the gingival crevicular fluid (GCF) of patients with chronic periodontitis, there is no evidence of GCF cytokine-based predictive models being used to diagnose the disease. Our objectives were: to obtain GCF cytokine-based predictive models; and develop nomograms derived from them. A sample of 150 participants was recruited: 75 periodontally healthy controls and 75 subjects affected by chronic periodontitis. Sixteen mediators were measured in GCF using the Luminex 100™ instrument: GMCSF, IFNgamma, IL1alpha, IL1beta, IL2, IL3, IL4, IL5, IL6, IL10, IL12p40, IL12p70, IL13, IL17A, IL17F and TNFalpha...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912020/intestinal-dysbiosis-featuring-abundance-of-ruminococcus-gnavus-associates-with-allergic-diseases-in-infants
#19
Huey-Huey Chua, Hung-Chieh Chou, Ya-Ling Tung, Bor-Luen Chiang, Chien-Chia Liao, Hong-Hsing Liu, Yen-Hsuan Ni
BACKGROUND & AIMS: Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS: We studied fecal specimens prospectively in a twin cohort (n=30) and age-matched singletons (n=14) born at National Taiwan University Children's Hospital, Taipei, Taiwan, from April 2011 to March 2013...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28887380/proteomic-signature-reveals-modulation-of-human-macrophage-polarization-and-functions-under-differing-environmental-oxygen-conditions
#20
Magali Court, Graciane Petre, Michèle El-Atifi, Arnaud Millet
Macrophages are innate immune cells which can react to a large number of environmental stimuli thanks to a high degree of plasticity. These cells are involved in a variety of tissue functions in homeostasis, and they play essential roles in pathological contexts. Macrophages’ activation state, which determines their functional orientation, is strongly influenced by the cellular environment. A large body of macrophage literature is devoted to better defining polarizations from a molecular viewpoint. It is now accepted that a multidimensional model of polarization is needed to grasp the broad phenotype repertoire controlled by environmental signals...
September 8, 2017: Molecular & Cellular Proteomics: MCP
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