keyword
MENU ▼
Read by QxMD icon Read
search

IL13

keyword
https://www.readbyqxmd.com/read/29771307/assessment-of-rosacea-symptom-severity-by-genome-wide-association-study-and-expression-analysis-highlights-immuno-inflammatory-and-skin-pigmentation-genes
#1
Jennifer L Aponte, Mathias N Chiano, Laura M Yerges-Armstrong, David A Hinds, Chao Tian, Akansha Gupta, Cong Guo, Dana J Fraser, Johannes M Freudenberg, Deepak K Rajpal, Margaret G Ehm, Dawn M Waterworth
Rosacea is a common, chronic skin disease of variable severity with limited treatment options. The cause of rosacea is unknown, but it is believed to be due to a combination of hereditary and environmental factors. Little is known about the genetics of the disease. We performed a genome-wide association study (GWAS) of rosacea symptom severity with data from 73,265 research participants of European ancestry from the 23andMe customer base. Seven loci had variants associated with rosacea at the genome-wide significance level (p≤5 × 10-8)...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29761786/association-of-a-four-locus-gene-model-including-il13-il4-fcer1b-and-adrb2-with-the-asthma-predictive-index-and-atopy-in-chinese-han-children
#2
S Bai, L Hua, X Wang, Q Liu, Y Bao
BACKGROUND AND OBJECTIVE: Asthma is a complex and heterogeneous disease. We found that gene-gene interactions among IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 in asthmatic children of Chinese Han nationality. This four-locus set constituted an optimal statistical interaction model. Objective: This study examined associations of the four-gene model consisting of IL13, IL4, FCER1B, and ADRB2 with the Asthma Predictive Index (API) and atopy in Chinese Han children...
May 11, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29753051/variation-in-doses-and-duration-of-particulate-matter-exposure-in-bronchial-epithelial-cells-results-in-upregulation-of-different-genes-associated-with-airway-disorders
#3
Priya Tripathi, Furong Deng, Anne M Scruggs, Yahong Chen, Steven K Huang
Exposure to particulate matter < 2.5 μm (PM2.5 ) is associated with a variety of airway diseases. Although studies have demonstrated that high doses of PM2.5 cause cytotoxicity and changes to gene expression in bronchial epithelial cells, the effect of lower doses and repeated exposure to PM2.5 are less well studied. Here, we treated BEAS-2B cells with varying doses of PM2.5 for 1-7 days and examined the expression of a variety of genes implicated in airway disorders. At high doses, PM2.5 increased the expression of IL6, TNF, TSLP, CSF2, PTGS2, IL4R, and SPINK5...
May 9, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29736291/optimization-of-cytokine-milieu-to-reproduce-atopic-dermatitis-related-gene-expression-in-hacat-keratinocyte-cell-line
#4
Hee Joo Kim, Jinok Baek, Jong Rok Lee, Joo Young Roh, YunJae Jung
Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine milieu required for accurate reproduction of AD-related gene expression profile in vitro , we evaluated the expression pattern of CCL22 , CCL17 , IL5 , IL13 , IL33 , IL25 , TSLP , FLG , and LOR in human lesional AD skin and cytokine-stimulated HaCaT cells. An increase in Th2 mediators ( IL5 , IL13 , CCL22 , CCL17, IL25 , IL33 , and TSLP ) and a decrease in genes related to cornified cell envelope (filaggrin and loricrin) were observed in human AD lesions...
April 2018: Immune Network
https://www.readbyqxmd.com/read/29716632/multi-cellular-human-bronchial-models-exposed-to-diesel-exhaust-particles-assessment-of-inflammation-oxidative-stress-and-macrophage-polarization
#5
Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde, Lena Palmberg
BACKGROUND: Diesel exhaust particles (DEP) are a major component of outdoor air pollution. DEP mediated pulmonary effects are plausibly linked to inflammatory and oxidative stress response in which macrophages (MQ), epithelial cells and their cell-cell interaction plays a crucial role. Therefore, in this study we aimed at studying the cellular crosstalk between airway epithelial cells with MQ and MQ polarization following exposure to aerosolized DEP by assessing inflammation, oxidative stress, and MQ polarization response markers...
May 2, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29677388/engulfment-of-hb-activated-platelets-differentiates-monocytes-into-pro-inflammatory-macrophages-in-pnh-patients
#6
Rashi Singhal, Sheetal Chawla, Harish Batra, Sameer Gupta, Amrita Ojha, Deepak K Rathore, Tulika Seth, Prasenjit Guchhait
The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions have put the heterogeneity of these cells into focus of investigation for several diseases. Recently we have described that after engulfing Hb-activated platelets, classical monocytes differentiated into pro-inflammatory phenotypes, which were abundant in the circulation of PNH and SCD patients. Our current study shows that upon engulfment of Hb-activated platelets, monocytes differentiate into M1-macrophages under M1-polarization stimulus (GM-CSF, IFN-γ+LPS)...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29676778/indirect-co-cultures-of-healthy-mesenchymal-stem-cells-restore-the-physiological-phenotypic-profile-of-psoriatic-mesenchymal-stem-cells
#7
A Campanati, M Orciani, G Sorgentoni, V Consales, M Mattioli Belmonte, R Di Primio, A Offidani
Psoriasis microenvironment, characterized by an imbalance between Th1/Th17 and Th2 cytokines, influences also mesenchymal stem cells (MSCs) phenotypic profile. MSCs from healthy donors (H-MSCs) can exert a strong paracrine effect by secreting active soluble factors, able to modulate the inflammation in the microenvironment. To evaluate the influence of H-MSCs on MSCs from psoriatic patients (PsO-MSCs), H-MSCs and PsO-MSCs were isolated and characterized. Indirect co-culture of H-MSCs with PsO-MSCs was performed; effects on proliferation and expression of cytokines linked to Th1/Th17 and Th2 pathways were assayed before and after co-culture...
April 20, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29670225/il-13-may-be-involved-in-the-development-of-cad-via-different-mechanisms-under-different-conditions-in-a-chinese-han-population
#8
Ling-Feng Zha, Shao-Fang Nie, Qian-Wen Chen, Yu-Hua Liao, Hong-Song Zhang, Jiang-Tao Dong, Tian Xie, Fan Wang, Ting-Ting Tang, Ni Xia, Cheng-Qi Xu, Ying-Chao Zhou, Zhi-Peng Zeng, Jiao Jiao, Peng-Yun Wang, Qing K Wang, Xin Tu, Xiang Cheng
Interleukin-13 (IL-13) has important functions in atherosclerosis, but its role in coronary artery disease (CAD) is unclear. Here, we studied the genetic role of IL-13 in CAD in a Chinese Han population using tag SNPs covering the whole IL13 gene (i.e., rs1881457, rs2069744 and rs20541) and a two-stage cohort containing 1863 CAD cases and 1841 controls. Traditional risk factors for CAD, such as age, BMI, and other factors, were used as covariates in logistic regression analysis. In the total population, we found that two haplotypes of IL13 (ATG and ATA, ordered rs1881457C -rs2069744T -rs20541A ) significantly contributed to the risk of CAD with adjusted p values less than 0...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665135/hepatocellular-carcinoma-is-associated-with-gut-microbiota-profile-and-inflammation-in-non-alcoholic-fatty-liver-disease
#9
Francesca Romana Ponziani, Sherrie Bhoori, Chiara Castelli, Lorenza Putignani, Licia Rivoltini, Federica Del Chierico, Maurizio Sanguinetti, Daniele Morelli, Francesco Paroni Sterbini, Valentina Petito, Sofia Reddel, Riccardo Calvani, Chiara Camisaschi, Anna Picca, Alessandra Tuccitto, Antonio Gasbarrini, Maurizio Pompili, Vincenzo Mazzaferro
The gut-liver axis plays a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is the third cause of hepatocellular carcinoma (HCC) worldwide. However, the link between gut microbiota and hepatocarcinogenesis remains to be clarified. The aim of this study is to explore what features of the gut microbiota are associated with HCC in cirrhotic patients with NAFLD. A consecutive series of patients with NAFLD-related cirrhosis and HCC (group 1: 21 patients), NAFLD-related cirrhosis without HCC (group 2: 20 patients) and healthy controls (group 3: 20 patients) was studied for gut microbiota profile, intestinal permeability, inflammatory status and circulating mononuclear cells...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29655556/in-vitro-bioassessment-of-the-immunomodulatory-activity-of-saccharomyces-cerevisiae-components-using-bovine-macrophages-and-mycobacterium-avium-ssp-paratuberculosis
#10
Z Li, H Kang, Q You, F Ossa, P Mead, M Quinton, N A Karrow
The yeast Saccharomyces cerevisiae and its components are used for the prevention and treatment of enteric disease in different species; therefore, they may also be useful for preventing Johne's disease, a chronic inflammatory bowel disease of ruminants caused by Mycobacterium avium ssp. paratuberculosis (MAP). The objective of this study was to identify potential immunomodulatory S. cerevisiae components using a bovine macrophage cell line (BOMAC). The BOMAC phagocytic activity, reactive oxygen species production, and immune-related gene (IL6, IL10, IL12p40, IL13, IL23), transforming growth factor β, ARG1, CASP1, and inducible nitric oxide synthase expression were investigated when BOMAC were cocultured with cell wall components from 4 different strains (A, B, C, and D) and 2 forms of dead yeast from strain A...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29557246/dupilumab-for-treatment-of-atopic-dermatitis
#11
Marlene Seegräber, Jerome Srour, Alexandra Walter, Macarena Knop, Andreas Wollenberg
Dupilumab is a new treatment option for patients with moderate-to-severe atopic dermatitis. It blocks IL-4/IL13-signaling and thereby inhibits receptor signaling downstream the JAK-STAT-pathway. Three of the main disease mechanisms of atopic dermatitis are affected by blocking this pathway; the decrease of skin barrier function, the class switch to IgE and the TH2-differentiation. Areas Covered: Dupilumab showed promising results in clinical trials of phase I-III. Clinical outcome parameters such as SCORAD, EASI, IGA and BSA improved with dupilumab...
March 20, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29543810/identification-of-plasma-biomarkers-for-discrimination-between-tuberculosis-infection-disease-and-pulmonary-non-tuberculosis-disease
#12
Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
We used the Luminex Bead Array Multiplex Immunoassay to measure cytokines, chemokines and growth factors responses to the same antigens used for RD1-based Interferon γ Release Assay (IGRA) test. Seventy-nine individuals, 27 active TB, 32 latent infection subsets, 20 individuals derivative purified protein (PPD) negative (subjects that do not have any indurative cutaneous reaction after 72 hrs of intradermal injection of PPD) and with other pulmonary disease were retrospectively studied. Forty-eight analytes were evaluated by Luminex Assay in plasma obtained from whole blood stimulated cells...
2018: PloS One
https://www.readbyqxmd.com/read/29518416/allergen-induced-activation-of-natural-killer-cells-represents-an-early-life-immune-response-in-the-development-of-allergic-asthma
#13
Matthew C Altman, Elizabeth Whalen, Alkis Togias, George T O'Connor, Leonard B Bacharier, Gordon R Bloomberg, Meyer Kattan, Robert A Wood, Scott Presnell, Petra LeBeau, Katy Jaffee, Cynthia M Visness, William W Busse, James E Gern
BACKGROUND: Childhood asthma in inner-city populations is a major public health burden, and understanding early-life immune mechanisms that promote asthma onset is key to disease prevention. Children with asthma demonstrate a high prevalence of aeroallergen sensitization and TH 2-type inflammation; however, the early-life immune events that lead to TH 2 skewing and disease development are unknown. OBJECTIVE: We sought to use RNA sequencing of PBMCs collected at age 2 years to determine networks of immune responses that occur in children with allergy and asthma...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29517628/th1-and-th2-cytokine-profiles-as-predictors-of-severity-in-acute-pancreatitis
#14
Antonio Rodriguez-Nicolas, Alba Martínez-Chamorro, Pilar Jiménez, Ana M Matas-Cobos, Eduardo Redondo-Cerezo, Francisco Ruiz-Cabello
OBJECTIVES: Acute pancreatitis (AP) is severe in up to 20% of patients, with a high mortality rate. Quantification of serum TH1 and TH2 cytokines may provide objective evidence to assess the severity of AP and predict its course. METHODS: One hundred seventeen patients were studied, measuring serum concentrations of interleukin (IL)1β, IL2, IL4, IL5, IL6, IL10, IL12p70, IL13, IL18, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN) γ, and tumor necrosis factor (TNF) α...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29513071/identification-of-targets-of-interleukin-13-and-signal-transducer-and-activator-of-transcription-6-stat6-signaling-in-polycystic-kidney-disease
#15
Erin E Olsan, Jonathan D West, Jacob A Torres, Nicholas Doerr, Thomas Weimbs
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a life-threatening, highly prevalent monogenic disease caused by mutations in polycystin-1 (PC1) in 85% of patients. We have previously identified a C-terminal cleavage fragment of PC1, PC1-p30, that interacts with the transcription factor STAT6 to promote transcription. STAT6 is aberrantly active in PKD mouse models and human ADPKD, and genetic removal or pharmacological inhibition of STAT6 attenuates disease progression. High levels of interleukin-13 (IL13), a STAT6 activating cytokine, are found in the cyst fluid of PKD mouse models and increased IL13 receptors in ADPKD patient tissue suggesting that a positive feedback loop between IL13 and STAT6 is activated in cystic epithelial cells and contributes to disease progression...
March 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29485045/blocking-interleukin-il-4-and-il13-mediated-phosphorylation-of-stat6-tyr641-decreases-m2-polarization-of-macrophages-and-protects-against-macrophage-mediated-radioresistance-of-inflammatory-breast-cancer
#16
Omar M Rahal, Adam R Wolfe, Pijus K Mandal, Richard Larson, Sanda Tin, Cristina Jimenez, Dadong Zhang, Janet Horton, James M Reuben, John S McMurray, Wendy A Woodward
PURPOSE: To determine the role of macrophage polarization on the response of inflammatory breast cancer (IBC) cells to radiation and whether modulation of macrophage plasticity can alter radiation response. METHODS AND MATERIALS: The human THP-1 monocyte cell line and primary human monocytes isolated from peripheral blood mononuclear cells were differentiated into macrophages and polarized to either an "antitumor" (M1) or a "protumor" (M2) phenotype...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29483769/asthma-and-poly-adp-ribose-polymerase-inhibition-a-new-therapeutic-approach
#17
REVIEW
Raffaela Zaffini, Giovanni Gotte, Marta Menegazzi
Asthma is a chronic lung disease affecting people of all ages worldwide, and it frequently begins in childhood. Because of its chronic nature, it is characterized by pathological manifestations, including airway inflammation, remodeling, and goblet cell hyperplasia. Current therapies for asthma, including corticosteroids and beta-2 adrenergic agonists, are directed toward relieving the symptoms of the asthmatic response, with poor effectiveness against the underlying causes of the disease. Asthma initiation and progression depends on the T helper (Th) 2 type immune response carried out by a complex interplay of cytokines, such as interleukin (IL) 4, IL5, and IL13, and the signal transducer and activator of transcription 6...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29477032/3d-3-culture-a-tool-to-unveil-macrophage-plasticity-in-the-tumour-microenvironment
#18
Sofia P Rebelo, Catarina Pinto, Tatiana R Martins, Nathalie Harrer, Marta F Estrada, Pablo Loza-Alvarez, José Cabeçadas, Paula M Alves, Emilio J Gualda, Wolfgang Sommergruber, Catarina Brito
The tumour microenvironment (TME) shapes disease progression and influences therapeutic response. Most aggressive solid tumours have high levels of myeloid cell infiltration, namely tumour associated macrophages (TAM). Recapitulation of the interaction between the different cellular players of the TME, along with the extracellular matrix (ECM), is critical for understanding the mechanisms underlying disease progression. This particularly holds true for prediction of therapeutic response(s) to standard therapies and interrogation of efficacy of TME-targeting agents...
May 2018: Biomaterials
https://www.readbyqxmd.com/read/29456669/expression-of-dact1-in-children-with-asthma-and-its-regulation-mechanism
#19
Cunxue Zhang, Peili Yang, Yan Chen, Jing Liu, Xiutai Yuan
The aim of the present study was to detect DACT1 expression levels in the lungs of children with asthma, and to investigate its role and molecular mechanisms in regulating the expression of inflammatory factors in RAW264.7 cells. DACT1, DACT2 and DACT3 expression was analyzed in biopsy specimens from 10 cases of newly diagnosed children with asthma and 10 healthy controls by reverse transcription-quantitative polymerase chain reaction, and their expression was confirmed in RAW264.7 cells. DACT1 expression was silenced by small interfering RNA or enhanced by transfection of pcDNA-3...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29427986/airway-inflammation-and-inflammatory-biomarkers
#20
Hui Fang Lim, Parameswaran Nair
Severe asthma is a complex disease consisting of different endotypes with different inflammatory and clinicopathological characteristics due to the heterogeneity of immune responses and smooth muscle dysfunction. There is an unmet clinical need to develop and to validate biomarkers that can differentiate between the asthma endotypes and guide clinical management, particularly since the availability of biologicals directed against T2 cytokines. The presence of a "Th2 endotype" is currently assessed in clinical practice using markers, such as eosinophil count in sputum or blood, fraction of exhaled nitric oxide, and immunoglobulin E...
February 2018: Seminars in Respiratory and Critical Care Medicine
keyword
keyword
53809
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"