keyword
https://read.qxmd.com/read/38540311/cimetidine-attenuates-therapeutic-effect-of-anti-pd-1-and-anti-pd-l1-and-modulates-tumor-microenvironment-in-colon-cancer
#21
JOURNAL ARTICLE
Feng-Chi Kuo, Jerry Cheng-Yen Lai, Hui-Ru Shieh, Wan-Zu Liou, Ming-Jong Bair, Yu-Jen Chen
Histamine modulates immunity by binding to histamine receptor 2 (H2R). Cimetidine, an H2R antagonist that inhibits gastric acid secretion and treats gastrointestinal ulcers, interferes with histamine-mediated immunomodulation and may have anticancer activity. This study examined cimetidine's effect on the anticancer effect of anti-PD-L1 in colon cancer. The MTT assay, colony formation assay, and DNA histograms assessed cell viability, clonogenicity, and cell cycle distribution, respectively. Flow cytometry measured H2R and PD-L1 expression and estimated specific immune cell lineages...
March 21, 2024: Biomedicines
https://read.qxmd.com/read/38539913/stigmasterol-exerts-an-anti-melanoma-property-through-down-regulation-of-reactive-oxygen-species-and-programmed-cell-death-ligand-1-in-melanoma-cells
#22
JOURNAL ARTICLE
Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Phil-Dong Moon
Cancer immunotherapy as a promising anti-cancer strategy has been widely studied in recent years. Stigmasterol (STIG), a phytosterol, is known to have various pharmacological effects, including anti-inflammatory effects. However, the pharmacological role of STIG on melanoma immunotherapy has not been investigated. The present study demonstrates the anti-melanoma potency of STIG through the regulation of PD-L1 levels. The results reveal that STIG reduces reactive oxygen species (ROS) levels induced by hydrogen peroxide and increases glutathione levels decreased by α-MSH in B16F10 cells...
March 21, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539569/regulation-of-pd-l1-expression-by-yy1-in-cancer-therapeutic-efficacy-of-targeting-yy1
#23
REVIEW
Ana Dillen, Indy Bui, Megan Jung, Stephanie Agioti, Apostolos Zaravinos, Benjamin Bonavida
During the last decade, we have witnessed several milestones in the treatment of various resistant cancers including immunotherapeutic strategies that have proven to be superior to conventional treatment options, such as chemotherapy and radiation. This approach utilizes the host's immune response, which is triggered by cancer cells expressing tumor-associated antigens or neoantigens. The responsive immune cytotoxic CD8+ T cells specifically target and kill tumor cells, leading to tumor regression and prolongation of survival in some cancers; however, some cancers may exhibit resistance due to the inactivation of anti-tumor CD8+ T cells...
March 21, 2024: Cancers
https://read.qxmd.com/read/38539559/her2-and-pd-l1-expression-in-gastric-and-gastroesophageal-junction-cancer-insights-for-combinatorial-targeting-approaches
#24
JOURNAL ARTICLE
Marta Baptista Freitas, Irene Gullo, Dina Leitão, Lúcia Águas, Carla Oliveira, António Polónia, Joana Gomes, Fátima Carneiro, Celso Albuquerque Reis, Henrique Oliveira Duarte
Gastric and gastroesophageal junction adenocarcinomas (GA/GEJA) are associated with a poor prognosis, primarily due to late disease diagnosis. Human Epidermal Growth Factor Receptor 2 (HER2) overexpression and programmed death-ligand 1 (PD-L1) expression are important biomarkers for treatment selection in locally advanced unresectable and metastatic GA/GEJA, and there is increasing interest in their role in earlier stages of disease. In this study, we aimed to evaluate HER2 and PD-L1 expression in a curative-intent GA/GEJA cohort to describe their expression patterns and analyze the association between HER2 expression and clinicopathological features...
March 20, 2024: Cancers
https://read.qxmd.com/read/38539511/immune-checkpoint-inhibitors-and-male-fertility-should-fertility-preservation-options-be-considered-before-treatment
#25
REVIEW
Elissavet Ntemou, Emily Delgouffe, Ellen Goossens
In recent years, immune checkpoint inhibitors (ICIs) have become a viable option for many cancer patients, including specific subgroups of pediatric patients. Despite their efficiency in treating different types of cancer, ICIs are responsible for a number of immune-related adverse events, including inflammatory toxicities, that can affect several organs. However, our knowledge of the impact of ICIs on the testis and male fertility is limited. It is possible that ICI treatment affects testicular function and spermatogenesis either directly or indirectly (or both)...
March 17, 2024: Cancers
https://read.qxmd.com/read/38539470/contrasting-roles-of-programmed-death-ligand-1-expression-in-tumor-and-stroma-in-prognosis-of-esophageal-squamous-cell-carcinoma
#26
JOURNAL ARTICLE
Tomohiro Murakami, Eisuke Booka, Satoru Furuhashi, Yuki Sakai, Kenichi Sekimori, Ryoma Haneda, Mayu Fujihiro, Tomohiro Matsumoto, Yoshifumi Morita, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Satoshi Baba, Hiroya Takeuchi
The assessment of programmed death-ligand 1 (PD-L1) expression in esophageal squamous cell carcinoma (ESCC) has become increasingly important with the rise of immune checkpoint inhibitors (ICIs). However, challenges persist, including subjective interpretation and the unclear significance of staining intensity, as well as contrasting roles in tumoral and stromal regions. Our study enhances the understanding of PD-L1 in ESCCs by analyzing its expression in tumors and stroma with H-scores, highlighting its distinct clinicopathological impacts...
March 13, 2024: Cancers
https://read.qxmd.com/read/38539461/pinpointing-functionally-relevant-mirnas-in-classical-hodgkin-lymphoma-pathogenesis
#27
REVIEW
Yujia Pan, Roza Cengiz, Joost Kluiver, Arjan Diepstra, Anke Van den Berg
Classical Hodgkin lymphoma (cHL) is a hematological malignancy of B-cell origin. The tumor cells in cHL are referred to as Hodgkin and Reed-Sternberg (HRS) cells. This review provides an overview of the currently known miRNA-target gene interactions. In addition, we pinpointed other potential regulatory roles of microRNAs (miRNAs) by focusing on genes related to processes relevant for cHL pathogenesis, i.e., loss of B-cell phenotypes, immune evasion, and growth support. A cHL-specific miRNA signature was generated based on the available profiling studies...
March 12, 2024: Cancers
https://read.qxmd.com/read/38539051/high-frequency-of-circulating-non-classical-monocytes-is-associated-with-stable-remission-in-relapsing-remitting-multiple-sclerosis
#28
JOURNAL ARTICLE
Misako Minote, Wakiro Sato, Kimitoshi Kimura, Atsuko Kimura, Youwei Lin, Tomoko Okamoto, Ryosuke Takahashi, Takashi Yamamura
'No evidence of disease activity (NEDA)', judged by clinical and radiological findings, is a therapeutic goal in patients with multiple sclerosis (MS). It is, however, unclear if distinct biological mechanisms contribute to the maintenance of NEDA. To clarify the immunological background of long-term disease stability defined by NEDA, circulating immune cell subsets in patients with relapsing-remitting MS (RRMS) were analyzed using flow cytometry. Patients showing long-term NEDA ( n  = 31) had significantly higher frequencies of non-classical monocytes (NCMs) (6...
March 27, 2024: Immunological Medicine
https://read.qxmd.com/read/38538739/artificial-intelligence-based-assessment-of-pd-l1-expression-in-diffuse-large-b-cell-lymphoma
#29
JOURNAL ARTICLE
Fang Yan, Qian Da, Hongmei Yi, Shijie Deng, Lifeng Zhu, Mu Zhou, Yingting Liu, Ming Feng, Jing Wang, Xuan Wang, Yuxiu Zhang, Wenjing Zhang, Xiaofan Zhang, Jingsheng Lin, Shaoting Zhang, Chaofu Wang
Diffuse large B cell lymphoma (DLBCL) is an aggressive blood cancer known for its rapid progression and high incidence. The growing use of immunohistochemistry (IHC) has significantly contributed to the detailed cell characterization, thereby playing a crucial role in guiding treatment strategies for DLBCL. In this study, we developed an AI-based image analysis approach for assessing PD-L1 expression in DLBCL patients. PD-L1 expression represents as a major biomarker for screening patients who can benefit from targeted immunotherapy interventions...
March 27, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38538366/-research-advances-of-myeloid-derived-suppressor-cells-mediated-by-programmed-death-1-programmed-death-ligand-1-pathway-in-sepsis-induced-immunosuppression
#30
JOURNAL ARTICLE
Yifei Xu, Xuefeng Zang, Wei Chen
Sepsis is a life-threatening organ dysfunction due to dysregulation of the body's response to infection. The immunosuppressive phase of sepsis is also an important cause of high morbidity and mortality in patients with advanced sepsis. Myeloid-derived suppressor cell (MDSC), as a heterogeneous population of Gr1+ CD11b+ immature cells, play a pivotal role in the immune process of advanced sepsis together with programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) with immunosuppressive properties. This review summarized the research progress of PD-1/PD-L1 pathway-mediated mechanism of MDSC in septic immunosuppression in recent years...
March 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38537980/different-influence-pattern-of-conventional-and-alternative-sources-of-smoking-on-adhesion-molecules-and-cytokine-secretion-in-thp-1-monocytes
#31
JOURNAL ARTICLE
Theresa Mohr, Eva Probst, Christian Idel, Kirstin Plötze-Martin, Jonas Fleckner, Dirk Rades, Daniel Drömann, Sabine Bohnet, Karl-Ludwig Bruchhage, Klaas F Franzen, Ralph Pries
BACKGROUND/AIM: Tobacco is a carcinogen that is closely associated with the occurrence of lung cancer and head and neck squamous cell carcinoma (HNSCC). The consumption of tobacco is also leading to alterations in different immune cell subtypes. However, the impact of different conventional and alternative smoking sources on human monocytes remains elusive. MATERIALS AND METHODS: In this study, we investigated the influence of aqueous extracts of different sources of smoking (cigarettes; heated tobacco product IQOS; e-cigarettes with and without nicotine; nicotine pouches) on different monocytic adhesion molecules, chemokine receptors and checkpoint molecule PD-L1 by flow cytometry...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537960/metabolic-tumor-volume-as-significant-predictor-for-chemotherapy-containing-pd-l1-blocker-in-extensive-stage-small-cell-lung-cancer
#32
JOURNAL ARTICLE
Kosuke Hashimoto, Kyoichi Kaira, Hisao Imai, Y U Miura, Ayako Shiono, Atsuto Mouri, O U Yamaguchi, Kunihiko Kobayashi, Hiroshi Kagamu, Ichiei Kuji
BACKGROUND/AIM: Chemo-immunotherapy, including the programmed death ligand 1 (PD-L1) antibody, is an effective treatment for patients with extensive-stage small-cell lung cancer (ES-SCLC). However, no biomarker has been established for the prediction of chemo-immunotherapy. Therefore, we investigated the potential of 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) as a predictive marker. PATIENTS AND METHODS: Forty-six patients with ES-SCLC who received 18 F-FDG-PET immediately before combined platinum-based chemotherapy with PD-L1 blockade as a first-line treatment were eligible, and the maximum standard uptake value (SUVmax ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on 18 F-FDG uptake were evaluated...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537717/m-mdscs-mediated-trans-bbb-drug-delivery-for-suppression-of-glioblastoma-recurrence-post-standard-treatment
#33
JOURNAL ARTICLE
Tong Yu, Kai Wang, Jianwei Wang, Yupeng Liu, Tingting Meng, Fuqiang Hu, Hong Yuan
We found that immunosuppressive monocytic-myeloid-derived suppressor cells (M-MDSCs) were more likely to be recruited by glioblastoma (GBM) through adhesion molecules on GBM-associated endothelial cells upregulated post-chemoradiotherapy. These cells are continuously generated during tumor progression, entering tumors and expressing PD-L1 at a high level, allowing GBM to exhaust T cells and evade attack from the immune system, thereby facilitating GBM relapse. αLy-6C-LAMP is composed of (i) drug cores with slightly negative charges condensed by cationic protamine and plasmids encoding PD-L1 trap protein, (ii) pre-formulated cationic liposomes targeted to Ly-6C for encapsulating the drug cores, and (iii) a layer of red blood cell membrane on the surface for effectuating long-circulation...
March 25, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38537440/tanshinone-iia-induces-er-stress-and-jnk-activation-to-inhibit-tumor-growth-and-enhance-anti-pd-1-immunotherapy-in-non-small-cell-lung-cancer
#34
JOURNAL ARTICLE
Yi-Zhong Zhang, Huan-Ling Lai, Chen Huang, Ze-Bo Jiang, Hao-Xin Yan, Xuan-Run Wang, Chun Xie, Ju-Min Huang, Wen-Kang Ren, Jia-Xin Li, Zhi-Ran Zhai, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung
BACKGROUND: Non-small cell lung cancer (NSCLC) remains at the forefront of new cancer cases, and there is an urgent need to find new treatments or improve the efficacy of existing therapies. In addition to the application in the field of cerebrovascular diseases, recent studies have revealed that tanshinone IIA (Tan IIA) has anticancer activity in a variety of cancers. PURPOSE: To investigate the potential anticancer mechanism of Tan IIA and its impact on immunotherapy in NSCLC...
February 7, 2024: Phytomedicine
https://read.qxmd.com/read/38534948/biomarker-turnaround-times-and-impact-on-treatment-decisions-in-patients-with-advanced-non-small-cell-lung-carcinoma-at-a-large-canadian-community-hospital-with-an-affiliated-regional-cancer-centre
#35
JOURNAL ARTICLE
Katelyn E Fleming, Ava Hupel, Hamid Mithoowani, Tea Lulic-Kuryllo, Mario Valdes
Background : Timely reporting of molecular biomarkers is critical in guiding optimal treatment decisions in patients with advanced non-small cell lung carcinoma (NSCLC). Any delays along the tissue or treatment pathway may be associated with suboptimal treatment/outcomes and a reduced quality of life. For many centres, biomarkers are tested off-site. Methods: A retrospective chart review of 123 patients with advanced NSCLC seen between 1 June 2021 and 30 June 2022 was conducted. With a focus on core biomarkers (PD L1, EGFR, and ALK), the outcome variables were as follows: total turnaround time (total TAT), divided into pre-laboratory, laboratory, and post-laboratory time intervals, as well as time to treatment decision (TOTD) and time to optimal systemic therapy decision (TOTSD)...
March 14, 2024: Current Oncology
https://read.qxmd.com/read/38534752/anti-tumor-potential-of-post-translational-modifications-of-pd-1
#36
REVIEW
Xiaoming Xi, Wuli Zhao
Programmed cell death protein-1 (PD-1) is a vital immune checkpoint molecule. The location, stability, and protein-protein interaction of PD-1 are significantly influenced by post-translational modification (PTM) of proteins. The biological information of PD-1, including its gene and protein structures and the PD-1/PD-L1 signaling pathway, was briefly reviewed in this review. Additionally, recent research on PD-1 post-translational modification, including the study of ubiquitination, glycosylation, phosphorylation, and palmitoylation, was summarized, and research strategies for PD-1 PTM drugs were concluded...
March 6, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533515/tigit-acts-as-an-immune-checkpoint-upon-inhibition-of-pd1-signaling-in-autoimmune-diabetes
#37
JOURNAL ARTICLE
Prerak Trivedi, Gaurang Jhala, David J De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W Kay, Helen E Thomas, Balasubramanian Krishnamurthy
INTRODUCTION: Chronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibiting PD1/PD-L1 signaling results in autoimmune diabetes in mice and humans with pre-existing autoimmunity against beta cells. However, it is not known if other immune checkpoint molecules, such as TIGIT, can also negatively regulate self-reactive T cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533512/exploring-the-clinical-significance-of-il-38-correlation-with-pd-1-ctla-4-and-foxp3-in-colorectal-cancer-draining-lymph-nodes
#38
JOURNAL ARTICLE
Liuhong Yuan, Zhenyu Tan, Junjie Huang, Feier Chen, Brett D Hambly, Shisan Bao, Kun Tao
INTRODUCTION: Colorectal cancer (CRC) presents a substantial challenge characterized by unacceptably high mortality and morbidity, primarily attributed to delayed diagnosis and reliance on palliative care. The immune response of the host plays a pivotal role in carcinogenesis, with IL-38 emerging as a potential protective factor in CRC. However, the precise involvement of IL-38 among various leucocytes, its interactions with PD-1/PD-L1, and its impact on metastasis require further elucidation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533509/role-of-cd38-in-anti-tumor-immunity-of-small-cell-lung-cancer
#39
JOURNAL ARTICLE
Hirokazu Taniguchi, Shweta S Chavan, Andrew Chow, Joseph M Chan, Hiroshi Mukae, Charles M Rudin, Triparna Sen
INTRODUCTION: Immune checkpoint blockade (ICB) with or without chemotherapy has a very modest benefit in patients with small cell lung cancer (SCLC). SCLC tumors are characterized by high tumor mutation burden (TMB) and low PD-L1 expression. Therefore, TMB and PD-L1 do not serve as biomarkers of ICB response in SCLC. CD38, a transmembrane glycoprotein, mediates immunosuppression in non-small cell lung cancer (NSCLC). In this brief report, we highlight the potential role of CD38 as a probable biomarker of immunotherapy response in SCLC...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533389/myeloid%C3%A2-derived-suppressor-cell-accumulation-induces-treg-expansion-and-modulates-lung-malignancy-progression
#40
JOURNAL ARTICLE
Yinghua Wan, Xiangdong Mu, Jingquan Zhao, Li Li, Wenshuai Xu, Mingqiang Zhang
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous family of myeloid cells that suppress T cell immunity in tumor-bearing hosts. The present study aimed to examine roles of T and MDSC subsets in lung malignancy. The study analyzed 102 cases with lung malignancy and 34 healthy individuals. Flow cytometry was performed for identification of T cell and MDSC subsets and their phenotypic characteristics in peripheral blood. The lung malignancy cases exhibited lower frequencies of granulocyte-like MDSCs (G-MDSCs) expressing PD-L2 and PD-L1 than healthy controls (P=0...
April 2024: Biomedical Reports
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