Yuka Kozawa, Akiko Yamamoto, Miyuki Nakakuki, Kotoyo Fujiki, Shiho Kondo, Takuto Okada, Tomoya Fukuyasu, Makoto Yamaguchi, Itsuka Taniguchi, Nao Nomura, Libin Liu, Mayuko Higuchi, Erina Niwa, Yoshiro Sohma, Satoru Naruse, Yoshifumi Takeyama, Hiroshi Ishiguro
Cystic fibrosis (CF) is an autosomal recessive disease caused by pathogenic variants in CF transmembrane conductance regulator (CFTR). While CF is the most common hereditary disease in Caucasians, it is rare in East Asia. In the present study, we have examined clinical features and the spectrum of CFTR variants of CF patients in Japan. Clinical data of 132 CF patients were obtained from the national epidemiological survey since 1994 and CF registry. From 2007 to 2022, 46 patients with definite CF were analyzed for CFTR variants...
May 22, 2023: Journal of Human Genetics