L C Berkhout, M J l'Ami, S Kruithof, E H Vogelzang, F Hooijberg, M H Hart, A E H Bentlage, D Thomas, S Vermeire, G Vidarsson, A Ten Brinke, M T Nurmohamed, G J Wolbink, T Rispens
BACKGROUND AND PURPOSE: Millions of patients with inflammatory diseases are treated with TNF inhibitors (TNFi). Individual treatment response varies, in part related to variable drug clearance. The role of TNF-TNFi complexes in clearance of the different TNFi is controversial. Moreover, mechanistic insight into the structural aspects and biological significance of TNF-TNFi complexes is lacking. We hypothesized a role for Fc-mediated clearance of TNF-TNFi immune complexes. Therefore, we investigated circulating TNF-TNFi complexes upon treatment with certolizumab - lacking Fc tails - in comparison to adalimumab, golimumab, infliximab and etanercept...
October 20, 2023: British Journal of Pharmacology