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https://www.readbyqxmd.com/read/28211593/higher-infliximab-trough-levels-are-associated-with-perianal-fistula-healing-in-patients-with-crohn-s-disease
#1
A J Yarur, V Kanagala, D J Stein, F Czul, M A Quintero, D Agrawal, A Patel, K Best, C Fox, K Idstein, M T Abreu
BACKGROUND: Infliximab has been found to be efficacious in the treatment of fistulas in the setting of Crohn's disease, even though some patients do not benefit from therapy. AIM: To assess the correlation between perianal fistula healing and trough levels of infliximab. METHODS: In this cross-sectional study, we identified patients with Crohn's disease who had perianal fistulas and were treated with infliximab for at least 24 weeks. We excluded patients who underwent a faecal diversion procedure or proctectomy...
February 17, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28195852/a-real-life-population-pharmacokinetic-study-reveals-factors-associated-with-clearance-and-immunogenicity-of-infliximab-in-inflammatory-bowel-disease
#2
Johannan F Brandse, Diane Mould, Oscar Smeekes, Yaël Ashruf, Sabine Kuin, Anne Strik, Gijs R van den Brink, Geert R DʼHaens
BACKGROUND: Several factors influencing the pharmacokinetics of infliximab (IFX) in inflammatory bowel disease (IBD) have been identified. We studied the impact of patient, disease, and treatment characteristics on clearance and immunogenicity of IFX in a real-world patient-with-IBD cohort. METHODS: Serum concentrations of IFX and antibodies to IFX (ATIs) were measured in patients with IBD at a single center using an enzyme-linked immunosorbent assay and radioimmunoassay...
February 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28175178/p639-switching-from-originator-infliximab-to-biosimilar-infliximab-in-ibd-patients-does-not-lead-to-significant-changes-in-infliximab-trough-levels
#3
A Eberl, S Huoponen, T Pahikkala, P Arkkila, M Blom, T Sipponen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175159/p643-therapeutic-thresholds-for-infliximab-trough-levels-during-maintenance-treatment-in-patients-with-inflammatory-bowel-disease
#4
M Rasmussen, J Brynskov, M A Ainsworth, S Buhl, K Bendtzen, C Steenholdt
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175156/p645-the-introduction-of-infliximab-therapeutic-drug-level-monitoring-for-is-associated-with-cost-savings-in-a-cohort-of-patients-in-a-large-district-general-hospital
#5
S Whiteoak, H Johnson, C Hovell, S Weaver, S McLaughlin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175129/p562-real-life-infliximab-trough-levels-among-inflammatory-bowel-disease-patients-on-maintenance-therapy-should-we-redefine-therapeutic-range-based-on-inflammatory-load
#6
T Lobaton, F Cañete, A Teniente, E Cabre, M Mañosa, E Martínez, E Domènech
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175110/p367-the-availability-of-infliximab-trough-levels-in-ibd-patients-on-maintenance-therapy-deeply-impacts-therapeutic-decision-making
#7
T Lobaton, F Cañete, A Teniente, E Cabre, M Mañosa, E Martínez, E Domènech
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175077/p424-association-between-infliximab-trough-levels-clinical-remission-mucosal-healing-and-quality-of-life-in-patients-with-inflammatory-bowel-disease-on-maintenance-therapy
#8
R S Parra, M R Feitosa, O Féres, J J R D Rocha
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174997/p119-higher-levels-of-infliximab-may-alleviate-the-need-of-azathioprine-comedication-in-the-treatment-of-patients-with-crohn-s-disease-a-sonic-post-hoc-analysis
#9
J-F Colombel, O J Adedokun, C Gasink, K Tang, F Cornillie, G D'Haens, P Rutgeerts, W Reinisch, W Sandborn, S Hanauer
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173040/p600-infliximab-trough-levels-for-remission-induction-and-long-term-therapy-management-of-inflammatory-bowel-disease
#10
D Perdigoto, F Portela, M Ferreira, S Mendes, P Freire, M Ferreira, S Lopes, L Tomé
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172853/p560-trough-levels-at-induction-impact-on-long-term-response-when-re-initiating-infliximab
#11
C Liefferinckx, C Minsart, J-F Toubeau, A Cremer, L Amininejad, E Quertinmont, J Devière, A Gils, A Van Gossum, D Franchimont
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172820/p426-supra-therapeutic-infliximab-levels-are-not-associated-with-a-higher-risk-of-infection-in-ibd-patients
#12
T Greener, B Kabakchiev, M Silverberg
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172729/p422-patient-near-infliximab-trough-level-testing-by-a-novel-quantitative-rapid-test-the-quantum-blue-infliximab-assay
#13
A Roseth, I Lindsjô, G-H Malmstrøm
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172694/p254-relationship-between-severe-endoscopic-lesions-and-plasmatic-and-fecal-infliximab-levels-in-acute-severe-ulcerative-colitis-a-case-control-study
#14
F Poullenot, D Nivet, S Paul, J Ricard, X Roblin, D Laharie
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172647/p481-serum-levels-of-infliximab-associate-with-early-mucosal-healing-in-crohn-s-disease-different-therapeutic-window-between-post-induction-and-maintenance-treatment
#15
T Feng, B Chen, R Mao, S Ben-Horin, M Chen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172534/p406-clinical-correlations-of-infliximab-trough-levels-and-antibodies-to-infliximab-in-korean-patients-with-crohn-s-disease
#16
E H Oh, D-H Ko, H Seo, K Chang, G-U Kim, E M Song, M Seo, H-S Lee, S W Hwang, D-H Yang, B D Ye, J-S Byeon, S-J Myung, S-K Yang, S H Park
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172523/dop031-subtherapeutic-serum-infliximab-trough-levels-and-complete-mucosal-healing-are-associated-with-sustained-clinical-remission-after-infliximab-discontinuation-in-paediatric-crohn-s-disease-patients
#17
B Kang, K Lee, K Kim, J H Lee, Y H Choe
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28158970/tumor-necrosis-factor-alpha-inhibitors-have-no-effect-on-a-human-t-lymphotropic-virus-type-i-htlv-i-infected-cell-line-from-patients-with-htlv-i-associated-myelopathy
#18
Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama, Atsushi Kawakami
BACKGROUND: While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify whether the TNFi sometimes used to treat patients with rheumatoid arthritis (RA) complicated with human T-lymphotropic virus type-I (HTLV-I) infection have the unintended side effect of promoting HTLV-I proliferation. METHODS: We used the HTLV-I-infected cell line HCT-5, derived from spinal fluid cells of a patient with HTLV-I associated myelopathy, to evaluate the production of cytokines and chemokines, TNF-α receptor (TNFR), the expression of HTLV-I associated genes, the HTLV-I proviral load (PVL), the expression of HTLV-I structural protein, and apoptosis...
February 3, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28147377/case-report-acute-flair-of-ulcerative-colitis-during-pregnancy-is-still-a-major-problem
#19
Marijana Protic, Srdjan Markovic, Dino Tarabar
Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes. It is critical to optimize aggressive medical treatment with both mother and fetal health. Here, we present a case of a 30-year-old woman with a severe flare of UC at the 16th gestational week. The diagnosis of extensive UC was established 8 years ago. From the time she was diagnosed, she had 5 moderate flares successfully treated with oral and topical mesalamine...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28147374/experience-with-biosimilar-infliximab-remsima%C3%A2-in-norway
#20
Jørgen Jahnsen, Kristin Kaasen Jørgensen
BACKGROUND: The first monoclonal antibody biosimilar to be used in clinical practice is the tumour necrosis factor-alpha inhibitor Remsima® (CT-P13). The drug is approved for all indications as the originator infliximab (Remicade®) although clinical efficacy has been demonstrated only in rheumatic diseases. Since the fall of 2013, Remsima® has been available in Norway and from January 2014, it has been the drug of choice when initiating biological treatment in biologics naïve patients with inflammatory bowel disease (IBD)...
2017: Digestive Diseases
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