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https://www.readbyqxmd.com/read/28644115/evaluation-of-the-effectiveness-and-cost-effectiveness-of-lightweight-fibreglass-heel-casts-in-the-management-of-ulcers-of-the-heel-in-diabetes-a-randomised-controlled-trial
#1
William Jeffcoate, Frances Game, Vivienne Turtle-Savage, Alison Musgrove, Patricia Price, Wei Tan, Lucy Bradshaw, Alan Montgomery, Deborah Fitzsimmons, Angela Farr, Thomas Winfield, Ceri Phillips
BACKGROUND: Ulcers of the foot in people with diabetes mellitus are slow to heal and result in considerable cost and patient suffering. The prognosis is worst for ulcers of the heel. OBJECTIVE: To assess both the clinical effectiveness and the cost-effectiveness of lightweight fibreglass casts in the management of heel ulcers. DESIGN: A pragmatic, multicentre, parallel, observer-blinded randomised controlled trial. A central randomisation centre used a computer-generated random number sequence to allocate participants to groups...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28643380/microscopy-visualisation-confirms-multi-species-biofilms-are-ubiquitous-in-diabetic-foot-ulcers
#2
Khalid Johani, Matthew Malone, Slade Jensen, Iain Gosbell, Hugh Dickson, Honhua Hu, Karen Vickery
Increasing evidence within the literature has identified the presence of biofilms in chronic wounds and proposed that they contribute to delayed wound healing. This research aimed to investigate the presence of biofilm in diabetic foot ulcers (DFUs) using microscopy and molecular approaches and define if these are predominantly mono- or multi-species. Secondary objectives were to correlate wound observations against microscopy results in ascertaining if clinical cues are useful in detecting wound biofilm. DFU tissue specimens were obtained from 65 subjects...
June 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28641786/association-of-apolipoprotein-ciii-apoc-iii-endothelium-dependent-vasodilation-and-peripheral-neuropathy-in-a-multi-ethnic-population-with-type-2-diabetes
#3
Sharon Li Ting Pek, Chee Fang Sum, Lee Ying Yeoh, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim, Subramaniam Tavintharan
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes (T2D). Apart from hyperglycemia, its pathogenesis is poorly understood. Apolipoprotein-CIII (apoC-III) associated with triglyceride metabolism, is a risk factor for cardiovascular disease. Its role in DPN is not well-established. We studied the associations of apoC-III, endothelial function and DPN. METHODS: In patients with T2D, anthropometric data, fasting blood, and urine were collected for biochemistry and urine albumin/creatinine measurements (uACR)...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28641320/transcutaneous-oximetry-measurements-of-the-leg-comparing-different-measuring-equipment-and-establishing-values-in-healthy-young-adults
#4
Tobias P Trinks, Denise F Blake, Derelle A Young, Ken Thistlethwaite, Venkat N Vangaveti
INTRODUCTION: Transcutaneous oximetry measurement (TCOM) is a non-invasive method of determining oxygen tension at the skin level using heated electrodes. AIM: To compare TCOM values generated by different machines and to establish lower limb TCOM values in a cohort of healthy individuals younger than 40 years of age. METHOD: Sixteen healthy, non-smoking volunteers aged 18 to 39 years were recruited. TCOM was obtained at six locations on the lower leg and foot using three different Radiometer machines...
June 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28639250/regulation-of-nephrin-phosphorylation-in-diabetes-and-chronic-kidney-injury
#5
Benoit Denhez, Pedro Geraldes
Diabetes is the leading cause of microalbuminuria and end-stage renal failure in industrial countries. Disruption of the filtration barrier, seen in almost all nephrotic diseases and diabetes, is the result of the loss or effacement of the podocyte foot process, notably damage of proteins within the slit diaphragm such as nephrin. For many years, nephrin has been viewed as a structural component of the slit diaphragm. It is now well recognized that nephrin contains several tyrosine residues in its cytoplasmic domain, which influences the development of glomerular injury...
June 22, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28638999/osteopontin-and-clusterin-levels-in-type-2-diabetes-mellitus-differential-association-with-peripheral-autonomic-nerve-function
#6
Raelene E Maser, M James Lenhard, Ryan T Pohlig, P Babu Balagopal
Osteopontin (OPN) and clusterin are secreted glycoproteins potentially associated with nerve function. Sudomotor dysfunction is associated with the development of foot ulcerations. The purpose of this study was to investigate the potential relationship of OPN and clusterin with sudomotor function (i.e., autonomic nerves that control sweating) in participants with type 2 diabetes mellitus (T2DM). Sudomotor function was assessed using SUDOSCAN® which measures electrochemical skin conductance (ESC) of the hands and feet...
June 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28638815/diabetic-foot-workshop-improving-technical-and-educational-skills-for-nurses
#7
Maryam Aalaa, Mahnaz Sanjari, Samimeh Shahbazi, Zahra Shayeganmehr, Maryam Abooeirad, Mohammad Reza Amini, Hossien Adibi, Neda Mehrdad
Diabetes mellitus as one of the most common metabolic disorders has some complications, one of the main ones is diabetic foot (DF). Appropriate care and education prevents 85% of diabetic foot amputations. An ideal management to prevent and treat diabetic foot necessitates a close collaboration between the health team members and the diabetic patient. Therefore, improving nurses' knowledge about DF care and advancement in the quality of care provided by the nurses could significantly improve diabetic foot prevention and management...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28638013/-surgical-treatment-of-diabetic-neuroosteoarthropathy-dnoap-and-its-long-term-results
#8
V M Bensman, Yu P Savchenko, S E Gumenyuk, K G Triandafilov, P P Vasil'chenko, S N Pyatakov, V V Khoritonenko
AIM: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP). MATERIAL AND METHODS: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal. Tarso-metatarsal arthrodesis was created after synovectomy in median foot to restore longitudinal arch. Cruro-calcaneal neoarthrosis was performed after elimination of posterior focus of DNOAP...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28637356/-footsnap-a-new-mobile-application-for-standardizing-diabetic-foot-images
#9
Moi Hoon Yap, Katie E Chatwin, Choon-Ching Ng, Caroline A Abbott, Frank L Bowling, Satyan Rajbhandari, Andrew J M Boulton, Neil D Reeves
BACKGROUND: We describe the development of a new mobile app called "FootSnap," to standardize photographs of diabetic feet and test its reliability on different occasions and between different operators. METHODS: FootSnap was developed by a multidisciplinary team for use with the iPad. The plantar surface of 30 diabetic feet and 30 nondiabetic control feet were imaged using FootSnap on two separate occasions by two different operators. Reproducibility of foot images was determined using the Jaccard similarity index (JSI)...
June 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28634883/a-minimal-continuous-time-markov-pharmacometric-model
#10
Emilie Schindler, Mats O Karlsson
In this work, an alternative model to discrete-time Markov model (DTMM) or standard continuous-time Markov model (CTMM) for analyzing ordered categorical data with Markov properties is presented: the minimal CTMM (mCTMM). Through a CTMM reparameterization and under the assumption that the transition rate between two consecutive states is independent on the state, the Markov property is expressed through a single parameter, the mean equilibration time, and the steady-state probabilities are described by a proportional odds (PO) model...
June 20, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28628147/-association-between-social-support-and-self-management-behaviors-among-patients-with-diabetes-in-community
#11
(no author information available yet)
OBJECTIVE: To study the status quo of directive and nondirective support from family or friends among patients with diabetes in community and to explore the association between directive, nondirective support from family or friends and self-management behaviors. METHODS: The data of the subjects were from the "Community Diagnosis in Tongzhou District, Beijing" survey. Questionnaire-based investigation, physical examination and glycated hemoglobin test were conducted on 474 eligible patients in community...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627865/the-value-of-color-doppler-ultrasound-in-the-diagnosis-of-lower-extremity-vascular-disease-in-type-2-diabetes-and-an-analysis-of-related-factors
#12
Le Jiang, Yuehua Zhao
BACKGROUND: The aim of this paper is to explore the application and clinical significance of color Doppler ultrasound (CDU) in diagnosing lower extremity vascular disease in type 2 diabetes mellitus (T2DM) patients. METHODS: The lower extremity arteries of 81 patients with T2DM and 50 control patients were examined by CDU for blood vessel diameter, intima-media thickness, plaque on the vessel wall, lumen stenosis and filling defect in blood flow. The occurrence of diabetes mellitus was investigated in additional T2DM patients of various ages...
September 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28627227/smarter-sole-survival
#13
Bijan Najafi, Eyal Ron, Ana Enriquez, Ivan Marin, Javad Razjouyan, David G Armstrong
OBJECTIVE: This study examined adherence to alert-based cues for plantar pressure offloading in patients with diabetic foot disease. METHOD AND DESIGN: Participants (n = 17) with in diabetic foot remission (history of neuropathic ulceration) were instructed to wear a smart insole system (the SurroSense Rx, Orpyx Medical Technologies Inc, Calgary, Canada) over a three-month period. This device is designed to cue offloading to manage unprotected sustained plantar pressures in an effort to prevent foot ulceration...
January 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28627224/real-time-smart-textile-based-system-to-monitor-pressure-offloading-of-diabetic-foot-ulcers
#14
Andrea Raviglione, Roberto Reif, Maurizio Macagno, Davide Vigano, Justin Schram, David Armstrong
BACKGROUND: The lifetime risk of developing a diabetic foot ulcer (DFU) is at least 25%. A DFU carries a 50% risk for infection and at least 20% of those receive some form of amputation. The most significant parameter that prevents or delays ulcer healing is high plantar pressure. To improve the patient's healing process, the DFU's plantar pressure should remain cumulatively low. Therefore, a tool that continuously measures the DFU loading, and provides real-time feedback can improve the healing outcome...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28626899/consideration-of-the-presence-of-inflammation-is-essential-for-interpretation-of-serum-micronutrient-results
#15
Emma Osland
It was with great interest I read the recent contribution by Christie-David and Gunton, 'Vitamin C deficiency and diabetes mellitus - easily missed?' [1], outlining their retrospective cohort study in 11 patients with poorly healing foot ulcers in the setting of diabetes mellitus. Their findings suggest previously unrecognized vitamin C deficiency may have been a contributing factor to the ulcers that were being treated in their clinic; a hypothesis supported by the healing reported to occur within 3 weeks of the commencement of vitamin C replacement [1]...
June 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28626746/frequency-of-cutaneous-fungal-infections-and-azole-resistance-of-the-isolates-in-patients-with-diabetes-mellitus
#16
Omid Raiesi, Mansour Siavash, Faezeh Mohammadi, Javaher Chabavizadeh, Behzad Mahaki, Mehrnoush Maherolnaghsh, Parvin Dehghan
BACKGROUND: Diabetic patients are more susceptible to cutaneous fungal infections. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. The main objective of this study was to find the frequency of fungal infections among cutaneous lesions of diabetic patients and to investigate azole antifungal agent susceptibility of the isolates. MATERIALS AND METHODS: In this study, type 1diabetes (n = 78) and type 2 diabetes (n = 44) comprised 47 cases (38...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28622094/self-care-behavior-change-and-depression-among-low-income-predominantly-hispanic-patients-in-safety-net-clinics
#17
Hyunsung Oh, Kathleen Ell, Lawrence A Palinkas
This study examined whether changes in self-care behaviors during a 12-month period predicted the likelihood of screening positive for depression concurrently and prospectively among low-income Hispanic patients with diabetes. Secondary analyses were conducted with longitudinal data collected from a randomized controlled trial that had tested effectiveness of collaborative depression care. We examined whether changes in self-care behaviors observed during the 12 months after baseline predicted the likelihood of screening positive for depression at 12-, 18-, and 24-month follow-up...
June 16, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28619242/insurance-coverage-and-diabetes-quality-indicators-among-patients-with-diabetes-in-the-us-general-population
#18
Emily D Doucette, Joanne Salas, Jing Wang, Jeffrey F Scherrer
This study explores associations between health insurance and diabetes quality indicators. Data were obtained from 8305 patients with diabetes who reported no insurance, Medicaid or private insurance in the 2013 BRFSS in 26 states in the US. Six diabetes quality indicators were assessed: HgbA1c testing, foot exam, eye exam, influenza immunization, pneumococcal immunization and diabetes education. Logistic regression was performed comparing quality indicators by insurance group adjusting for covariates. Subjects with private insurance or Medicaid were more likely than the uninsured to have HgbA1c testing (OR=2...
June 12, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28619097/adipose-tissue-derived-stromal-vascular-fraction-in-regenerative-medicine-a-brief-review-on-biology-and-translation
#19
REVIEW
Pablo Bora, Anish S Majumdar
Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs). Recently, both SVF and ADSCs have gained wide-ranging translational significance in regenerative medicine. Initially used for cosmetic breast enhancement, this mode of treatment has found use in many diseases involving immune disorders, tissue degeneration, and ischaemic conditions. In this review, we try to address several important aspects of this field, outlining the biology, technology, translation, and challenges related to SVF- and ADSC-based therapies...
June 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28618729/risk-factors-associated-with-poor-outcome-in-diabetic-foot-ulcer-patients
#20
Saira Saleem, Nazim Hayat, Irshad Ahmed, Tanvir Ahmed, Abdul Gaffar Rehan
BACKGROUND/AIM: Diabetic foot ulcers and related complications are a major cause of morbidity and hospital admissions. Our aim was to evaluate the risk factors associated with poor outcome in diabetic foot ulcers. MATERIALS AND METHODS: A prospective study was conducted on patients with diabetic foot ulceration attending the Madinah Teaching Hospital from June 2014 to December 2015. Potential risk factors and laboratory test results at presentation were recorded and their association with outcome (healing vs...
June 12, 2017: Turkish Journal of Medical Sciences
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