Liangliang Bai, Linping Wu, Changsheng Zhang, Zhiwen Liu, Liang Ma, Jing Ni, Dezhen He, Mingxuan Zhu, Shaoyong Peng, Xiaoxia Liu, Huichuan Yu, Yuhe Lei, Yanxin Luo, Yu Zhang, Xiaolin Wang, Gang Wei, Yingjie Li
Diabetic foot ulcer (DFU) is a highly morbid complication in patients with diabetes mellitus, necessitating the development of innovative pharmaceuticals to address unmet medical needs. Sodium ion (Na+ ) is a well-established mediator for membrane potential and osmotic equilibrium. Recently, Na+ transporters have been identified as a functional regulator of regeneration. However, the role of Na+ in the intricate healing process of mammalian wounds remains elusive. Here, we found that the skin wounds in hyponatremic mice display a hard-to-heal phenotype...
June 2024: Materials today. Bio