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https://www.readbyqxmd.com/read/28723797/correlation-between-elevated-platelet-count-and-immunoglobulin-levels-in-the-early-convalescent-stage-of-kawasaki-disease
#1
Ji-Whan Han, Jin-Hee Oh, Jung-Woo Rhim, Kyung-Yil Lee
Kawasaki disease (KD) may be an acute systemic immune-mediated disease which occurs after infection of unknown KD pathogen(s). The aim of this study is to evaluate the changes in platelet count and immunoglobulin (Ig) levels (IgG, IgM, IgA, and IgE) during hospitalization.Forty-three patients with complete KD who received intravenous Ig at 2 g/kg were enrolled in South Korea. The platelet count and Ig levels of the patients were examined twice at presentation and around discharge (mean 6.2 ± 2.4 days apart) and the relationships between platelet level and Ig levels were evaluated...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722337/validation-of-brain-derived-signals-in-near-infrared-spectroscopy-through-multivoxel-analysis-of-concurrent-functional-magnetic-resonance-imaging
#2
Yoshiya Moriguchi, Takamasa Noda, Kosei Nakayashiki, Yohei Takata, Shiori Setoyama, Shingo Kawasaki, Yoshihiko Kunisato, Kazuo Mishima, Kazuyuki Nakagome, Takashi Hanakawa
Near-infrared spectroscopy (NIRS) is a convenient and safe brain-mapping tool. However, its inevitable confounding with hemodynamic responses outside the brain, especially in the frontotemporal head, has questioned its validity. Some researchers attempted to validate NIRS signals through concurrent measurements with functional magnetic resonance imaging (fMRI), but, counterintuitively, NIRS signals rarely correlate with local fMRI signals in NIRS channels, although both mapping techniques should measure the same hemoglobin concentration...
July 19, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28722294/clinical-outcomes-of-balloon-angioplasty-alone-versus-nitinol-stent-implantation-in-patients-with-small-femoropopliteal-artery-disease-observations-from-the-retrospective-multicenter-analysis-for-femoropopliteal-stenting-real-fp
#3
Norihiko Kamioka, Yoshimitsu Soga, Shoichi Kuramitsu, Osamu Iida, Keisuke Hirano, Kenji Suzuki, Daizo Kawasaki, Terutoshi Yamaoka, Nobuhiro Suematsu, Yoshiaki Shintani, Yusuke Miyashita, Hiroki Takahashi, Taketsugu Tsuchiya, Norihiko Shinozaki, Shinya Okazaki, Kenji Ando
OBJECTIVES: We sought to assess whether balloon angioplasty (BA) alone for small femoropopliteal disease improved the outcome following endovascular therapy as compared with stent implantation. BACKGROUND: The optimal strategy of endovascular therapy for small vessel arteries in femoropopliteal disease remains unclear. METHODS: We performed a multicenter retrospective analysis of 337 consecutive patients (371 limbs) with femoropopliteal arteries 4...
July 19, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28720342/severe-hypoglycaemia-is-a-major-predictor-of-incident-diabetic-retinopathy-in-japanese-patients-with-type-2-diabetes
#4
S Tanaka, R Kawasaki, S Tanaka-Mizuno, S Iimuro, S Matsunaga, T Moriya, S Ishibashi, S Katayama, Y Ohashi, Y Akanuma, H Sone, H Yamashita
AIM: Hypoglycaemia is a common complication in diabetes patients. However, its relationship with retinopathy has not been well documented in patients with type 2 diabetes (T2D). This study aimed to investigate the associations between hypoglycaemia and the incidence and progression of diabetic retinopathy (DR). METHODS: In this longitudinal cohort study, which was part of the Japan Diabetes Complications Study (JDCS), adult patients with T2D were recruited at 59 diabetes clinics across Japan...
July 15, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28718879/streptococcal-induced-kawasaki-disease-of-the-psoriasiform-phenotype-in-a-young-adult
#5
Corey Georgesen, Karim Ladak, Joanna Harp, Cynthia Magro
No abstract text is available yet for this article.
July 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28718364/evaluation-of-epigenetic-inactivation-of-vascular-endothelial-growth-factor-receptors-in-head-and-neck-squamous-cell-carcinoma
#6
Yuki Misawa, Kiyoshi Misawa, Hideya Kawasaki, Atsushi Imai, Daiki Mochizuki, Ryuji Ishikawa, Shiori Endo, Masato Mima, Takeharu Kanazawa, Toshihide Iwashita, Hiroyuki Mineta
The aim of this study was to determine the methylation status of the genes encoding the vascular endothelial growth factor receptors and to evaluate the usefulness of VEGFR methylation as a prognostic indicator in head and neck squamous cell carcinoma. VEGFR messenger RNA expression and promoter methylation were examined in a panel of cell lines via quantitative reverse transcription and methylation-specific polymerase chain reaction, respectively. Promoter methylation was compared with clinical characteristics in 128 head and neck squamous cell carcinoma samples...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28713428/clinically-apparent-arterial-thrombosis-in-persons-with-systemic-vasculitis
#7
Alexander Tsoukas, Sasha Bernatsky, Lawrence Joseph, David L Buckeridge, Patrick Bélisle, Christian A Pineau
OBJECTIVE: To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis. METHODS: Using large cohort administrative data from Quebec, Canada, we identified patients with vasculitis, including polyarteritis nodosa (PAN) and granulomatosis with polyangiitis (GPA). Incident acute myocardial infarctions (AMIs) and cerebrovascular accidents (CVAs) after the diagnosis of vasculitis were ascertained in the PAN and GPA group via billing and hospitalization data...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28709219/erratum-relationship-between-bond-breakage-correlations-and-four-point-correlations-in-heterogeneous-glassy-dynamics-configuration-changes-and-vibration-modes-phys-rev-e-86-041504-2012
#8
Hayato Shiba, Takeshi Kawasaki, Akira Onuki
This corrects the article DOI: 10.1103/PhysRevE.86.041504.
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28707750/arterial-immune-protein-expression-demonstrates-the-complexity-of-immune-responses-in-kawasaki-disease-arteritis
#9
Scott A Cameron, Steven M White, David Arrollo, Stanford T Shulman, Anne H Rowley
BACKGROUND: A more complete understanding of immune-mediated damage to the coronary arteries in children with Kawasaki disease (KD) is required for improvements in patient treatment and outcomes. We recently reported the transcriptional profile of KD coronary arteritis, and here sought to determine protein expression of transcriptionally upregulated immune genes in KD coronary arteries from the first two months after disease onset. METHODS: We examined the coronary arteries of 12 fatal KD cases and 13 childhood controls for expression of a set of proteins whose genes were highly upregulated in the KD coronary artery transcriptome: allograft inflammatory factor 1 (AIF1), interleukin 18 (IL-18), CD74, CD1c, CD20 (MS4A1), Toll-like receptor 7 (TLR7), and Z-DNA binding protein 1 (ZBP1)...
July 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28707401/structural-and-functional-diversity-of-ef-hand-proteins-evolutionary-perspectives
#10
REVIEW
Hiroshi Kawasaki, Robert H Kretsinger
We have classified 865 sequences of EF-hand proteins from five proteomes into 156 subfamilies. These subfamilies were put into six groups. Evolutionary relationships among subfamilies and groups were analyzed from the inferred ancestral sequence for each subfamily. CTER, CPV, and PEF groups arose from a common EF-lobe (pair of adjacent EF-hands). They have two or more EF-lobes; the relative positions of their EF-lobes differ from each other. Comparisons of the ancestral sequences and the inferred structures of the EF-lobes of these groups indicate that the mutual positions of EF-lobes were established soon after divergence of an EF-lobe for each group and before the duplication and fusion of EF-lobe gene(s)...
July 13, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28706619/kawasaki-disease-presenting-with-bloody-diarrhea-and-acute-renal-failure-first-case
#11
Mary Jacqueline Saviour, Sam Hassan
Kawasaki disease (KD) is an acute febrile vasculitis of an unknown cause. It affects children <5 year of age, even if cases over 5 years old have been also reported. It is the commonest cause of acquired heart diseases in children which may lead to serious morbidity and mortality. The complications and mortality increase when the diagnosis is delayed. One of the main reasons leading to delayed diagnosis and consequent delayed treatment is the unusual presentation of KD. Its unusual manifestations have been increasingly reported to jeopardize the timely diagnosis and proper treatment...
June 26, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/28705837/cyb-1-a-c-elegans-b-type-cyclin-maintains-proper-position-and-number-of-centrosomes-during-spermatogenesis
#12
Sunghee Yoon, Ichiro Kawasaki, Yhong-Hee Shim
Depletion of cyb-1, a major B-type cyclin expressed during C. elegans spermatogenesis, caused a meiotic division arrest in diakinesis-stage spermatocytes with multiple and mispositioned centrosomes. Association of SUN-1 and ZYG-12, two nuclear membrane proteins, is critical for centrosome-nuclear envelope attachment. We found that sun-1 depletion caused centrosome defects similar to those caused by cyb-1 depletion in diakinesis-stage spermatocytes. In addition, Ser8 and Ser43 residues in SUN-1 were dephosphorylated in cyb-1-depleted diakinesis-stage spermatocytes...
July 13, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28704447/sexual-dimorphisms-of-mrna-and-mirna-in-human-murine-heart-disease
#13
Masato Tsuji, Takanori Kawasaki, Takeru Matsuda, Tomio Arai, Satoshi Gojo, Jun K Takeuchi
BACKGROUND: Sexual dimorphisms are well recognized in various cardiac diseases such as ischemic cardiomyopathy (ICM), hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Thorough understanding of the underlying genetic programs is crucial to optimize treatment strategies specified for each gender. By performing meta-analysis and microarray analysis, we sought to comprehensively characterize the sexual dimorphisms in the healthy and diseased heart at the level of both mRNA and miRNA transcriptome...
2017: PloS One
https://www.readbyqxmd.com/read/28702164/a-case-of-an-anomalous-biliary-tract-diagnosed-preoperatively
#14
Jun Kataoka, Toshikatsu Nitta, Yoshihiro Inoue, Masato Ota, Tomo Tominaga, Kensuke Fujii, Hiroshi Kawasaki, Takashi Ishibashi
We describe a 48-year-old man with cholecystolithiasis whose preoperative magnetic resonance cholangiopancreatography (MRCP) scan showed that the right accessory hepatic duct branching from the cystic duct dominated an anterior segment of the right hepatic lobe. We observed the right accessory hepatic duct using intraoperative cholangiography, and we were able to perform laparoscopic cholecystectomy without injuring it. He had no complication after discharge, and a drip-infusion cholangiography-computed tomography (DIC-CT) scan demonstrated that the right accessory hepatic duct was intact, and it dominated an anterior segment of the right hepatic lobe...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28701890/relationship-between-oxidative-stress-physical-activity-and-vitamin-intake-in-patients-with-asthma
#15
Akira Yamasaki, Yuji Kawasaki, Kenichi Takeda, Tomoya Harada, Yasuyuki Hasegawa, Takehito Fukushima, Ryota Okazaki, Haruhiko Makino, Yoshihiro Funaki, Yuriko Sueda, Akihiro Yamamoto, Jun Kurai, Masanari Watanabe, Eiji Shimizu
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of bronchial asthma. Antioxidant nutrition and supplementation have been used to reduce oxidative stress. However, a clinical trial with antioxidant supplementation showed no beneficial effects in patients with asthma. On the other hand, physical activity is related to the prognosis of chronic obstructive pulmonary disease (COPD) and is also related to oxidant status. We investigated the relationships between oxidative stress, serum levels of vitamins, dietary vitamin intake, daily activities, and pulmonary functions in patients with asthma...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28700965/inhibitory-effects-of-asp6537-a-selective-cyclooxygenase-1-inhibitor-on-thrombosis-and-neointima-formation-in-rats
#16
Chinatsu Sakata, Tomihisa Kawasaki, Yoshiyuki Iwatsuki, Yumiko Moritani, Yoshiaki Morita, Hideaki Hara
INTRODUCTION: Percutaneous coronary interventions (PCIs), such as balloon angioplasty and stent placement, are effective in the treatment of coronary artery disease. PCI has drawbacks, however, including acute thrombosis after the procedure and restenosis of the vascular lumen due to abnormal neointimal hyperplasia. ASP6537 is a selective COX-1 inhibitor that has been investigated as a possible candidate for clinical development as an antiplatelet agent. In the present study, we evaluated the in vivo antithrombotic effect of ASP6537 and its effect on neointima formation after balloon angioplasty...
July 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28700731/forward-flexion-of-trunk-in-parkinson-s-disease-patients-is-affected-by-subjective-vertical-position
#17
Kyohei Mikami, Makoto Shiraishi, Tsubasa Kawasaki, Tsutomu Kamo
PURPOSE: No method has been established to evaluate the dissociation between subjective and objective vertical positions with respect to the self-awareness of postural deformity in patients with Parkinson's disease (PD). The purpose of this study was to demonstrate, from the relationship between an assessment of the dissociation of subjective and objective vertical positions of PD patients and an assessment based on established PD clinical evaluation scales, that the dissociation regarding vertical position is a factor in the severity of the forward flexion of trunk (FFT)...
2017: PloS One
https://www.readbyqxmd.com/read/28699614/clinical-presentation-and-cardiovascular-outcome-in-complete-versus-incomplete-kawasaki-disease
#18
Shivalingam Ganji, Prashanth Gowda Parameshwara, Kallesh Hebbal, Rodney Aguiar
OBJECTIVE: To compare the demographic, clinical, and laboratory features of incomplete and complete presentations of Kawasaki disease. METHODS: A retrospective review of the electronic case records between January 2000 and December 2015 in a tertiary care referral center of Sohar, Oman. RESULTS: 31 out of 64 children (48.4%) had incomplete presentation. Children with incomplete presentation had higher incidence of skin rash, lymphadenopathy and conjunctivitis...
July 11, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28697838/-hypertension-and-intermittent-convulsions-for-one-month-in-a-school-age-child
#19
Mao-Qiang Tian, Shu-Yi Liu, Juan Li, Xiao-Mei Shu
Childhood polyarteritis nodosa (PAN) is a rare systemic vasculitis and the delayed diagnosis and treatment will cause high incidence of sequelae and high mortality. This article reports a girl with childhood PAN due to posterior reversible encephalopathy syndrome (PRES). The girl aged ten years was admitted to the hospital due to hypertension and convulsions for one month. She had complaints of headache, vomiting, and blurred vision before convulsions. At six months before admission, a mass was observed in the neck...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28697010/estimating-population-salt-intake-in-india-using-spot-urine-samples
#20
Kristina S Petersen, Claire Johnson, Sailesh Mohan, Kris Rogers, Roopa Shivashankar, Sudhir R Thout, Priti Gupta, Feng J He, Graham A MacGregor, Jacqui Webster, Joseph A Santos, Anand Krishnan, Pallab K Maulik, K Srinath Reddy, Ruby Gupta, Dorairaj Prabhakaran, Bruce Neal
OBJECTIVE: To compare estimates of mean population salt intake in North and South India derived from spot urine samples versus 24-h urine collections. METHODS: In a cross-sectional survey, participants were sampled from slum, urban and rural communities in North and in South India. Participants provided 24-h urine collections, and random morning spot urine samples. Salt intake was estimated from the spot urine samples using a series of established estimating equations...
July 10, 2017: Journal of Hypertension
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