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https://www.readbyqxmd.com/read/29139555/tauroursodeoxycholic-acid-inhibits-intestinal-inflammation-and-barrier-disruption-in-nafld-mice
#1
Weijun Wang, Jinfang Zhao, Wenfang Gui, Dan Sun, Haijiang Dai, Li Xiao, Huikuan Chu, Fan Du, Qingjing Zhu, Bernd Schnabl, Kai Huang, Ling Yang, Xiaohua Hou
BACKGROUND AND PURPOSE: The gut-liver axis is associated with the progression of non-alcoholic fatty liver disease (NAFLD). Targeting the gut-liver axis and bile acid-based pharmaceuticals are potential therapies for NAFLD. The effect of tauroursodeoxycholic acid (TUDCA), a candidate medicine for NAFLD, on intestinal barrier function, intestinal inflammation, gut lipid transport and microbiota composition in a murine NAFLD model were analysed. EXPERIMENTAL APPROACHES: An NAFLD mouse model was established by feeding mice with a high-fat diet (HFD) for 16 weeks...
November 15, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29138190/prevalence-of-non-communicable-disease-risk-factors-among-poor-shantytown-residents-in-dhaka-bangladesh-a-community-based-cross-sectional-survey
#2
Md Khalequzzaman, Chifa Chiang, Sohel Reza Choudhury, Hiroshi Yatsuya, Mohammad Abdullah Al-Mamun, Abubakr Ahmed Abdullah Al-Shoaibi, Yoshihisa Hirakawa, Bilqis Amin Hoque, Syed Shariful Islam, Akiko Matsuyama, Hiroyasu Iso, Atsuko Aoyama
OBJECTIVES: This study aims to describe the prevalence of non-communicable disease (NCD) risk factors among the urban poor in Bangladesh. DESIGN: We conducted a community-based cross-sectional epidemiological study. SETTING: The study was conducted in a shantytown in the city of Dhaka. There were 8604 households with 34 170 residents in the community. Those households were categorised into two wealth strata based on the housing structure...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137352/maternal-high-calorie-diet-induces-mitochondrial-dysfunction-and-senescence-phenotype-in-subcutaneous-fat-of-newborn-mice
#3
Daniele Lettieri-Barbato, Fabiana D'Angelo, Francesca Sciarretta, Giuseppe Tatulli, Flavia Tortolici, Maria Rosa Ciriolo, Katia Aquilano
Mitochondrial dysfunction, inflammation and senescence-like features are observed in adipose depots in aging and obesity. Herein, we evaluated how maternal high calorie diet (HCD) may impact on subcutaneous adipose tissue (sAT) of the newborn mice. Adult C57BL/6J mice were randomly divided in three groups: normal calorie diet (NCD), HCD and HCD supplemented with niacin 8 weeks before mating. Mothers and pups were then sacrificed and metabolic and molecular analyses were carried out on sAT. HCD induced mitochondria dysfunction in mothers without inflammation and senescence, whereas in pups we also revealed the occurrence of senescent phenotype...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133311/quantifying-research-output-on-poverty-and-non-communicable-disease-behavioural-risk-factors-in-low-income-and-lower-middle-income-countries-a-bibliometric-analysis
#4
Luke Nelson Allen, Nicholas Fox, Alissa Ambrose
OBJECTIVES: Low-income and lower middle-income countries (LLMICs) bear a disproportionate burden of non-communicable diseases (NCDs). WHO has repeatedly called for more research on poverty and NCDs in these settings, but the current situation remains unquantified. We aimed to assess research output on poverty and NCD risk factors from these countries in relation to upper middle-income and high-income countries. DESIGN: Bibliometric analysis of primary research published between 1 January 1990 and 4 May 2017...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29126454/an-analysis-on-intersectional-collaboration-on-non-communicable-chronic-disease-prevention-and-control-in-china-a-cross-sectional-survey-on-main-officials-of-community-health-service-institutions
#5
Xing-Ming Li, Alon Rasooly, Bo Peng, JianWang, Shu-Yu Xiong
BACKGROUND: Our study aimed to design a tool of evaluating intersectional collaboration on Non-communicable Chronic Disease (NCD) prevention and control, and further to understand the current status of intersectional collaboration in community health service institutions of China. METHODS: We surveyed 444 main officials of community health service institutions in Beijing, Tianjin, Hubei and Ningxia regions of China in 2014 by using a questionnaire. A model of collaboration measurement, including four relational dimensions of governance, shared goals and vision, formalization and internalization, was used to compare the scores of evaluation scale in NCD management procedures across community healthcare institutions and other ones...
November 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29123223/structural-basis-of-small-molecule-atpase-inhibition-of-a-human-mitotic-kinesin-motor-protein
#6
Hee-Won Park, Zhujun Ma, Haizhong Zhu, Shimin Jiang, Robert C Robinson, Sharyn A Endow
Kinesin microtubule motor proteins play essential roles in division, including attaching chromosomes to spindles and crosslinking microtubules for spindle assembly. Human kinesin-14 KIFC1 is unique in that cancer cells with amplified centrosomes are dependent on the motor for viable division because of its ability to cluster centrosomes and form bipolar spindles, but it is not required for division in almost all normal cells. Screens for small molecule inhibitors of KIFC1 have yielded several candidates for further development, but obtaining structural data to determine their sites of binding has been difficult...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29120837/cancer-risk-reduction-in-the-us-affiliated-pacific-islands-utilizing-a-novel-policy-systems-and-environmental-pse-approach
#7
Mavis Nitta, Dioreme Navasca, Aileen Tareg, Neal A Palafox
BACKGROUND: The Health Directors of the US Affiliated Pacific Islands (USAPI) declared a State of Emergency due to epidemic proportions of lifestyle diseases: cancer, obesity and other non-communicable diseases (NCDs) in 2010. This paper describes the development, implementation, and evaluation of a USAPI policy, system and environment (PSE) approach to address lifestyle behaviors associated with cancer and other NCDs. METHODS: Each of USAPI jurisdictions applied the PSE approach to tobacco and nutrition interventions in a local institution, faith based, or community setting...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29118982/uneven-distribution-of-professors-and-instructors-in-medical-disciplines-dealing-with-the-four-main-chronic-non-communicable-diseases-the-case-of-the-italian-universities
#8
Giovanni Viegi, Stefano Centanni, Francesco Blasi
Background: Chronic (non-communicable) diseases (NCD) -- principally cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes -- are leading causes of death and disability. There is the need to adopt a core University curriculum which let students be taught by teachers who are experts of the four main NCD, for reaching the public health goals proposed by the UN and the WHO. Methods: Our aim was to assess whether all medical students, regardless of the Italian university of enrolment, have an equal opportunity to be educated by an expert teacher in each of the four NCD...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29113807/cyanate-improves-insulin-sensitivity-and-hepatic-steatosis-in-normal-and-high-fat-fed-mice-anorexic-and-antioxidative-effects
#9
Seong Sik Kang, Kyo-Cheol Mun, Ji Hae Seo, Misun Choe, Eunyoung Ha
Obesity is an important contributing factor to progression of chronic kidney disease. Cyanate, known as uremic toxin, is an electrophile produced spontaneously from urea or by myeloperoxidase-catalyzed oxidation of thiocyanate. Herein, we explored metabolic effects of cyanate in normal chow diet (NCD)- and high fat diet (HFD)-fed mice. Mice were treated with cyanate (1 mg/mL in drinking water) and fed NCD or HFD. Peritoneal glucose tolerance test (PGTT) and insulin tolerance test (ITT) were performed. Blood urea nitrogen (BUN) and creatinine concentrations were determined...
November 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29113445/the-noncommunicable-disease-outcomes-of-primary-healthcare-screening-in-two-rural-subdistricts-of-the-eastern-cape-province-south-africa
#10
Paul Rheeder, Angela A Morris-Paxton, Rose-Marie G Ewing, Dillon Woods
BACKGROUND: Middle and lower income countries are challenged with a double burden of disease: while still coping with the onslaught of Human Immunodeficiency Virus (HIV) and increasing levels of tuberculosis (TB), there is a considerable increase in the level of noncommunicable diseases (NCDs). The poor are especially disadvantaged and are at an increased risk for NCDs. Adequate healthcare resources for this environment can only be allocated once the extent and exact nature of the problem is determined...
October 31, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29107974/significant-relationships-between-a-simple-marker-of-redox-balance-and-lifestyle-behaviours-relevance-to-the-framingham-risk-score
#11
Neda Seyedsadjadi, Jade Berg, Ayse A Bilgin, Chin Tung, Ross Grant
Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48) and females (n = 52) were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection...
2017: PloS One
https://www.readbyqxmd.com/read/29107293/the-mitochondrial-pyruvate-carrier-mediates-high-fat-diet-induced-increases-in-hepatic-tca-cycle-capacity
#12
Adam J Rauckhorst, Lawrence R Gray, Ryan D Sheldon, Xiaorong Fu, Alvin D Pewa, Charlotte R Feddersen, Adam J Dupuy, Katherine N Gibson-Corley, James E Cox, Shawn C Burgess, Eric B Taylor
OBJECTIVE: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial matrix, thereby gating pyruvate-driven gluconeogenesis. Disruption of the hepatocyte MPC attenuates hyperglycemia in mice during high fat diet (HFD)-induced obesity but exerts minimal effects on glycemia in normal chow diet (NCD)-fed conditions...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29106574/a-conceptual-framework-for-investigating-the-impacts-of-international-trade-and-investment-agreements-on-noncommunicable-disease-risk-factors
#13
Ashley Schram, Arne Ruckert, J Anthony VanDuzer, Sharon Friel, Deborah Gleeson, Anne-Marie Thow, David Stuckler, Ronald Labonte
We developed a conceptual framework exploring pathways between trade and investment and noncommunicable disease (NCD) outcomes. Despite increased knowledge of the relevance of social and structural determinants of health, the discourse on NCD prevention has been dominated by individualizing paradigms targeted at lifestyle interventions. We situate individual risk factors, alongside key social determinants of health, as being conditioned and constrained by trade and investment policy, with the aim of creating a more comprehensive approach to investigations of the health impacts of trade and investment agreements, and to encourage upstream approaches to combating rising rates of NCDs...
November 2, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29102994/excess-burden-of-non-communicable-disease-years-of-life-lost-from-heat-in-rural-burkina-faso-a-time-series-analysis-of-the-years-2000-2010
#14
Aditi Bunker, Maquins Odhiambo Sewe, Ali Sié, Joacim Rocklöv, Rainer Sauerborn
OBJECTIVES: Investigate the association of heat exposure on years of life lost (YLL) from non-communicable diseases (NCD) in Nouna, Burkina Faso, between 2000 and 2010. DESIGN: Daily time series regression analysis using distributed lag non-linear models, assuming a quasi-Poisson distribution of YLL. SETTING: Nouna Health and Demographic Surveillance System, Kossi Province, Rural Burkina Faso. PARTICIPANTS: 18 367 NCD-YLL corresponding to 790 NCD deaths recorded in the Nouna Health and Demographic Surveillance Site register over 11 years...
November 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29089779/online-continuing-medical-education-as-a-key-link-for-successful-noncommunicable-disease-self-management-the-casalud%C3%A2-model
#15
Héctor Gallardo-Rincón, Rodrigo Saucedo-Martínez, Ricardo Mujica-Rosales, Evan M Lee, Amy Israel, Braulio Torres-Beltran, Úrsula Quijano-González, Elena Rose Atkinson, Pablo Kuri-Morales, Roberto Tapia-Conyer
PURPOSE: The purpose of this study is to evaluate how the benefits of online continuing medical education (CME) provided to health care professionals traveled along a patient "educational chain". In this study, the educational chain begins with the influence that CME can have on the quality of health care, with subsequent influence on patient knowledge, disease self-management, and disease biomarkers. METHODS: A total of 422 patients with at least one noncommunicable disease (NCD) treated in eight different Mexican public health clinics were followed over 3 years...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29082839/addressing-ncds-a-unifying-agenda-for-sustainable-development
#16
Téa Collins, Bente Mikkelsen, Jennifer Adams, Oleg Chestnov, Tim Evans, Andrea Feigl, Rachel Nugent, Ariel Pablos-Mendez, Supattra Srivanichakorn, Douglas Webb
Despite the mounting evidence that they impede social and economic development, increase inequalities, and perpetuate poverty, Noncommunicable diseases (NCDs) remain largely absent from the agendas of major development assistance initiatives. In addition, fundamental changes are developing in patterns of development assistance for health, and more of the burden for fighting NCDs is being placed on domestic budgets, thus increasing pressure on the most vulnerable countries. The paper argues, however, that a new day is coming...
October 28, 2017: Global Public Health
https://www.readbyqxmd.com/read/29082745/cross-sectional-stepwise-approach-to-surveillance-steps-population-survey-of-noncommunicable-diseases-ncds-and-risk-factors-in-brunei-darussalam-2016
#17
Sok King Ong, Daphne Teck Ching Lai, Justin Yun Yaw Wong, Khairil Azhar Si-Ramlee, Lubna Abdul Razak, Norhayati Kassim, Zakaria Kamis, David Koh
This article provides a cross-sectional weighted measurement of noncommunicable diseases (NCDs) and risk factors prevalence among Brunei adult population using WHO STEPS methodology. A 2-staged randomized sampling was conducted during August 2015 to April 2016. Three-step surveillance included (1) interview using standardized questionnaire, (2) blood pressure and anthropometric measurements, and (3) biochemistry tests. Data weighting was applied. A total of 3808 adults aged 18 to 69 years participated in step 1; 2082 completed steps 2 and 3 measurements...
October 1, 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29082005/maternal-and-child-health-services-and-an-integrated-life-cycle-approach-to-the-prevention-of-non-communicable-diseases
#18
REVIEW
Luisa Brumana, Alvaro Arroyo, Nina R Schwalbe, Susanna Lehtimaki, David B Hipgrave
Described as the 'invisible epidemic', non-communicable diseases (NCDs) are the world's leading cause of death. Most are caused by preventable factors, including poor diet, tobacco use, harmful use of alcohol and physical inactivity. Diabetes, cancer and cardiovascular and chronic lung diseases were responsible for 38 million (68%) of global deaths in 2012. Since 1990, proportionate NCD mortality has increased substantially as populations have aged and communicable diseases decline. The majority of NCD deaths, especially premature NCD deaths (<70 years, 82%), occur in low-income and middle-income countries, and among poor communities within them...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29079553/c%C3%A3-te-d-ivoire-dual-burden-of-disease-codubu-study-protocol-to-investigate-the-co-occurrence-of-chronic-infections-and-noncommunicable-diseases-in-rural-settings-of-epidemiological-transition
#19
Ikenna C Eze, Clémence Esse, Fidèle K Bassa, Siaka Koné, Felix Acka, Loukou Yao, Medea Imboden, Fabienne N Jaeger, Christian Schindler, Mireille Dosso, Véronique Laubhouet-Koffi, Dinard Kouassi, Eliézer K N'Goran, Jürg Utzinger, Bassirou Bonfoh, Nicole Probst-Hensch
BACKGROUND: Individual-level concomitance of infectious diseases and noncommunicable diseases (NCDs) is poorly studied, despite the reality of this dual disease burden for many low- and middle-income countries (LMICs). OBJECTIVE: This study protocol describes the implementation of a cohort and biobank aiming for a better understanding of interrelation of helminth and Plasmodium infections with NCD phenotypes like metabolic syndrome, hypertension, and diabetes. METHODS: A baseline cross-sectional population-based survey was conducted over one year, in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d'Ivoire...
October 27, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29077240/training-and-assessing-critical-airway-breathing-and-hemorrhage-control-procedures-for-trauma-care-live-tissue-versus-synthetic-models
#20
Danielle Hart, Robert Rush, Gregory Rule, Joseph Clinton, Gregory Beilman, Shilo Anders, Rachel Brown, Mary Ann McNeil, Troy Reihsen, Jeffrey Chipman, Robert Sweet
INTRODUCTION: Optimal teaching and assessment methods and models for emergency airway, breathing and hemorrhage interventions are not currently known. The University of Minnesota Combat Casualty Training consortium (UMN CCTC) was formed to explore the strengths and weaknesses of synthetic training models (STMs) versus Live tissue (LT) models. In this study, we compare the effectiveness of best in class STMs versus an anesthetized caprine (goat) model for training and assessing 7 procedures: Junctional hemorrhage control, Tourniquet (TQ) placement, Chest seal, Needle thoracostomy (NCD), Nasopharyngeal airway (NPA), Tube thoracostomy, and Cricothyrotomy (Cric)...
October 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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