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https://www.readbyqxmd.com/read/28208718/on-line-screening-isolation-and-identification-of-antioxidant-compounds-of-helianthemum-ruficomum
#1
Yasmine Chemam, Samir Benayache, Eric Marchioni, Minjie Zhao, Paul Mosset, Fadila Benayache
Many Helianthemum species (Cistaceae) are recognized for their various medicinal virtues. Helianthemum ruficomum is an endemic species to the septentrional Sahara on which no report is available so far. The purpose of this work was to investigate the chemical composition and the radical scavenging capacity of this species and its isolated components. Collected from Mougheul (south-west of Algeria), the aerial parts were macerated with 80% EtOH/H₂O, after evaporation, the remaining extract was diluted with H₂O and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28203044/a-case-of-sitosterolemia-due-to-compound-heterozygous-mutations-in-abcg5-clinical-features-and-treatment-outcomes-obtained-with-colestimide-and-ezetimibe
#2
Sahoko Ono, Junko Matsuda, Aki Saito, Takenobu Yamamoto, Wataru Fujimoto, Hitomi Shimizu, Sumito Dateki, Kazunobu Ouchi
Sitosterolemia is a rare, autosomal recessively inherited disorder of lipid metabolism caused by mutations in the "ATP-binding cassette, subfamily G" member 5 and 8 proteins (encoded by the ABCG5 and ABCG8 genes, respectively), which play critical roles in the intestinal and biliary excretion of plant sterols. We report the clinical features and treatment outcomes of an 18-month-old Japanese girl with sitosterolemia, who presented with multiple linear and intertriginous xanthomas around the joint areas. Serum lipid analyses revealed elevated levels of total cholesterol (T-Chol: 866 mg/dL), low density lipoprotein-cholesterol (LDL-C: 679 mg/dL), and plant sterols (sitosterol: 24...
January 2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28191023/major-phytochemical-as-%C3%AE-sitosterol-disclosing-and-toxicity-testing-in-lagerstroemia-species
#3
Prapaparn Sirikhansaeng, Tawatchai Tanee, Runglawan Sudmoon, Arunrat Chaveerach
Medicinal plants in genus Lagerstroemia were investigated for phytochemical contents by GC-MS and HPLC with ethanol and hexane extracts and their toxicity MTT and comet assay on human peripheral blood mononuclear cells (PBMCs). γ-Sitosterol is the major component found in all species at 14.70-34.44%. All of the extracts, except for L. speciosa ethanol extract, showed high percentages of cell viability. The IC50 value, 0.24 mg/mL, of ethanol L. speciosa extract predicted an LD50 of 811.78 mg/kg, which belongs to WHO Class III of toxic chemicals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28185960/lipid-nanovehicles-with-adjustable-surface-properties-for-overcoming-multiple-barriers-simultaneously-in-oral-administration
#4
Lei Wu, Min Liu, Wei Shan, Yi Cui, Zhirong Zhang, Yuan Huang
Lipid nanoparticles (LNs) are widely investigated for oral drug delivery, and for achieving significant advantages in colloidal stability, biocompatibility and scaled-up possibility. However, researchers face challenge of developing methods to improve the ability of LNs in overcoming multiple barriers (i.e., mucus and epithelium barrier) in gastrointestinal (GI) tract because of the contradictory requirement of nanoparticle (NP) surface properties in the two processes. Therefore, we designed novel LNs with adjustable surface properties by coating lipid core with hydrophobic substitutes grafting N-(2-hydroxypropyl) methacrylamide copolymer (pHPMA)...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28177669/beta-sitosterol-up-regulated-paraoxonase-1-via-peroxisome-proliferator-activated-receptor-%C3%AE-in-irradiated-rats
#5
Enas Moustafa, Noura Magdy Thabet
This study was designed to evaluate the effect of Beta-sitosterol (BS) on the of peroxisome proliferator-activated receptor gamma (PPAR-γ) gene expression role in the activity of PON-1 enzyme in oxidative stress status of irradiated rats. Animals were exposed to whole body γ-radiation single dose 6Gy and received BS dose (40 mg•(kg body mass) -1•day -1, orally). In liver tissue, gene expression of PPAR-γ ligand was determined. Oxidative stress marker (malonyldialdehyde, MDA) and antioxidant enzymes activities (Superoxide dismutase; SOD Catalase; CAT, PON-1 and arylesterase; ARE) were assayed in serum and liver tissue...
January 24, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28173794/antibacterial-and-antioxidant-properties-of-crude-extract-fractions-and-compounds-from-the-stem-bark-of-polyscias-fulva-hiern-araliaceae
#6
Guy Sedar Singor Njateng, Zhizhi Du, Donatien Gatsing, Raymond Simplice Mouokeu, Yaping Liu, Hong-Xia Zang, Jianlong Gu, Xiaodong Luo, Jules-Roger Kuiate
BACKGROUND: In our previous work, the dichloromethane-methanol (1:1 v/v) extract, fractions and isolated compounds from Polyscias fulva stem bark showed interesting antifungal activity. As a continuity of that work, this study aimed to bring out complementary informations about the antimicrobial properties of P. fulva stem bark that may be useful in the standardization of phytomedicine from this plant. METHODS: The antibacterial activities of the crude extract, fractions (n-hexane, ethyl acetate, n-butanol and residual) and isolated compounds from Polyscias fulva stem bark were assayed by broth microdilution techniques...
February 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28166786/chemical-constituents-and-coagulation-activity-of-agastache-rugosa
#7
Pengran Cao, Pingyao Xie, Xuebiao Wang, Jinmei Wang, Jinfeng Wei, Wen-Yi Kang
BACKGROUND: In the Chinese traditional medicine, plant of Agastache rugosa (Fisch. & C.A. Mey.) Kuntze (A. rugosa) has been used to treat nausea, vomiting and dispel damp. However, currently, few reports about the chemical constituents, especially the non-volatile components of A. rugosa are available. METHODS: Through separation with various column chromatographies to elucidate the chemical constituents of A. rugosa, the biological activities of the major constituents were investigated...
February 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28165051/insights-into-structure-and-activity-of-natural-compound-inhibitors-of-pneumolysin
#8
Hongen Li, Xiaoran Zhao, Xuming Deng, Jianfeng Wang, Meng Song, Xiaodi Niu, Liping Peng
Pneumolysin is the one of the major virulence factor of the bacterium Streptococcus pneumoniae. In previous report, it is shown that β-sitosterol, a natural compound without antimicrobial activity, is a potent antagonist of pneumolysin. Here, two new pneumolysin natural compound inhibitors, with differential activity, were discovered via haemolysis assay. To explore the key factor of the conformation for the inhibition activity, the interactions between five natural compound inhibitors with differential activity and pneumolysin were reported using molecular modelling, the potential of mean force profiles...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163064/thermal-stability-of-plant-sterols-and-formation-of-their-oxidation-products-in-vegetable-oils-and-margarines-upon-controlled-heating
#9
Yuguang Lin, Diny Knol, Iris Valk, Vincent van Andel, Silvia Friedrichs, Dieter Lütjohann, Karel Hrncirik, Elke A Trautwein
Fat-based products like vegetable oils and margarines are commonly used for cooking, which may enhance oxidation of plant sterols (PS) present therein, leading to the formation of PS oxidation products (POP). The present study aims to assess the kinetics of POP formation in six different fat-based products. Vegetable oils and margarines without and with added PS (7.5-7.6% w/w) in esterified form were heated in a Petri-dish at temperatures of 150, 180 and 210°C for 8, 12 and 16min. PS and POP were analysed using GC-FID and GC-MS-SIM, respectively...
February 2, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28157655/phytosterols-as-a-natural-anticancer-agent-current-status-and-future-perspective
#10
REVIEW
Naiyer Shahzad, Wajahatullah Khan, Shadab Md, Asgar Ali, Sundeep Singh Saluja, Sadhana Sharma, Faisal A Al-Allaf, Zainularifeen Abduljaleel, Ibrahim Abdel Aziz Ibrahim, Ali Fathi Abdel-Wahab, Mohamed Abdelaziz Afify, Saeed Saeed Al-Ghamdi
Phytosterols are naturally occurring compounds in plants, structurally similar to cholesterol. The human diet is quite abundant in sitosterol and campesterol. Phytosterols are known to have various bioactive properties including reducing intestinal cholesterol absorption which alleviates blood LDL-cholesterol and cardiovascular problems. It is indicated that phytosterol rich diets may reduce cancer risk by 20%. Phytosterols may also affect host systems, enabling antitumor responses by improving immune response recognition of cancer, affecting the hormone dependent endocrine tumor growth, and by sterol biosynthesis modulation...
January 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28153468/anti-malarial-synergy-of-secondary-metabolites-from-morinda-lucida-benth
#11
Bertha Chithambo, Xavier Siwe Noundou, Rui W M Krause
ETHNOPHARMACOLOGICAL RELEVANCE: The roots, stem and leaves of Morinda lucida are used in some African countries as treatment against different types of fevers including yellow fever, malaria, trypanosomiasis and feverish conditions during child birth. AIM OF THE STUDY: To determine the in vitro cell toxicity and anti-malarial activity of the extracts of stem bark of M. lucida and to identify the secondary metabolites in the extract that may be responsible for this activity...
January 30, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28152649/anti-inflammatory-anti-cholinergic-and-cytotoxic-effects-of-sida-rhombifolia
#12
Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee
CONTEXT: Sida (Malvaceae) has been used as a traditional remedy for the treatment of diarrhoea, malarial, gastrointestinal dysentery, fevers, asthma and inflammation. OBJECTIVES: This study evaluates the anti-inflammatory, cytotoxic and anti-cholinergic activities of Sida rhombifolia Linn. whole plant for the first time. MATERIALS AND METHODS: S. rhombifolia whole plant was extracted by n-hexane, ethyl acetate and methanol using Soxhlet apparatus...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28130879/variations-in-dietary-intake-and-plasma-concentration-of-plant-sterols-across-plant-based-diets-among-north-american-adults
#13
Karen Jaceldo-Siegl, Dieter Lütjohann, Rawiwan Sirirat, Andrew Mashchak, Gary E Fraser, Ella Haddad
SCOPE: Phytosterols are bioactive compounds in plants with similar cholesterol-lowering properties as vegetarian diets. However, information on phytosterol intake and plasma plant sterols among vegetarians is sparse. METHODS AND RESULTS: We examined dietary intake and plasma concentration of plant sterols and cholesterol across five dietary patterns in the Adventist Health Study-2 Calibration Sub-study (n = 861, 66% females, average age 61 y). To measure intake and plasma concentration of these compounds, we used 24-hour dietary recalls and gas-liquid chromatography-flame ionization detection, respectively...
January 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28119186/phytosterols-isolated-from-clinacanthus-nutans-induce-immunosuppressive-activity-in-murine-cells
#14
Cheng-Foh Le, Thina Hareesh Kailaivasan, Sek-Chuen Chow, Zunoliza Abdullah, Sui-Kiong Ling, Chee-Mun Fang
Clinacanthus nutans (Burm. f.) Lindau is a traditional medicinal plant belonging to the Acanthaceae family. Its therapeutic potentials have been increasingly documented particularly the antiviral activity against Herpes Simplex Virus (HSV), anti-cancer, anti-oxidant, anti-inflammatory and immunomodulatory activities. However, majority of these studies used crude or fractionated extracts and not much is known about individual compounds from these extracts and their biological activities. In the present study, we have isolated four compounds (CN1, CN2, CN3 and CN4) from the hexane fractions of C...
January 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28112016/the-anti-inflammatory-effect-of-sonchus-oleraceus-aqueous-extract-on-lipopolysaccharide-stimulated-raw-264-7-cells-and-mice
#15
Qi Li, Dan-Dan Dong, Qiu-Ping Huang, Jing Li, Yong-Yong Du, Bin Li, Huan-Qing Li, Ting Huyan
CONTEXT: Sonchus oleraceus L. (Asteraceae) (SO) is a dietary and traditional medicinal plant in China. However, its underlying mechanism of action as an anti-inflammatory agent is not known. OBJECTIVE: This study evaluates the anti-inflammatory activity of aqueous extract of SO. MATERIALS AND METHODS: The extract of SO was used to treat RAW 264.7 cells (in the working concentrations of 500, 250, 125, 62.5, 31.3 and 15.6 μg/mL) for 24 h...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28100224/radical-scavenging-activities-of-lagerstroemia-speciosa-l-pers-petal-extracts-and-its-hepato-protection-in-ccl4-intoxicated-mice
#16
Bipransh Kumar Tiwary, Somit Dutta, Priyankar Dey, Mossaraf Hossain, Anoop Kumar, Sony Bihani, Ashis Kumar Nanda, Tapas Kumar Chaudhuri, Ranadhir Chakraborty
BACKGROUND: Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts. METHODS: Several spectroscopic methods, including GC-MS, were used to characterize phytochemicals present in the petal extract of L...
January 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28098355/a-comparative-study-on-composition-and-antioxidant-activities-of-supercritical-carbon-dioxide-hexane-and-ethanol-extracts-from-blackberry-rubus-fruticosus-growing-in-poland
#17
Anna Wajs-Bonikowska, Agnieszka Stobiecka, Radosław Bonikowski, Agnieszka Krajewska, Magdalena Sikora, Józef Kula
BACKGROUND: Large quantities of blackberry seeds are produced as a pomace during the processing of juice and jam production - this by-product is a very interesting raw material both for oil manufacturing and as a source of bioactive compounds. In this work the composition, yield and antioxidant activity of three types of Rubus fructicosus pomace extracts isolated by liquid-extraction using solvents of different polarity, as well with supercritical CO2 fluid extraction have been compared...
January 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28088325/molecular-dynamics-simulations-of-ternary-lipid-bilayers-containing-plant-sterol-and-glucosylceramide
#18
Shiva Emami, Sodeif Azadmard-Damirchi, Seyed Hadi Peighambardoust, Javad Hesari, Hadi Valizadeh, Roland Faller
An atomic-level molecular dynamics simulation was carried out to study the effects of a plant sterol (sitosterol) and glucosylceramide (GlcCer) on a 1,2-dilinoleoylposphocholine (DLiPC) membrane. Initially, a membrane containing 50mol% sitosterol was compared with that containing the same ratio of cholesterol. These simulations showed differential condensing and ordering effects of sitosterol and cholesterol, with cholesterol being slightly more efficient than sitosterol in packing the membrane more tightly to a liquid ordered phase...
January 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28078712/comparative-study-on-fatty-acid-composition-of-olive-olea-europaea-l-with-emphasis-on-phytosterol-contents
#19
Ali Ozkan, Hassan Y Aboul-Enein, Muhittin Kulak, Recep Bindak
The present study was designed to determine the fatty acid composition and phytosterol contents of Turkish native olive cultivars namely (Kilis Yağlık and Nizip Yağlık cv.). In this context, olive fruits from thirty-four locations were sampled and then screened for their components in comparison. Fifteen different fatty acids were found in both olive oils. In the order of abundance, the most important ones were: oleic acid (18:1) > palmitic acid (16:0) > linoleic acid (18:2) > stearic acid (18:0)...
January 12, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28078497/anti-inflammatory-effect-of-naravelia-zeylanica-dc-via-suppression-of-inflammatory-mediators-in-carrageenan-induced-abdominal-oedema-in-zebrafish-model
#20
Sanmuga Priya Ekambaram, Senthamil Selvan Perumal, Selvaranjani Pavadai
The traditional herbal medicines are receiving great importance in the health care sector, especially in Indian system of medicine, i.e, Ayurveda. The present study focused on the standardization of Naravelia zeylanica (L.) DC in terms of its active phytochemicals and to evaluate the anti-inflammatory activity of ethanol extract of N. zeylanica (ENZ). An analytical method was developed by high-performance liquid chromatography for simultaneous determination of β-sitosterol, lupeol and oleanolic acid in ENZ...
February 2017: Inflammopharmacology
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