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sitosterol

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https://www.readbyqxmd.com/read/27914018/encapsulation-of-%C3%AE-sitosterol-in-polyurethane-by-sol-gel-electrospinning
#1
Musarat Amina, Touseef Amna, Nawal Al-Musayeib, Sami A Zabin, M Shamshi Hassan, Myung-Seob Khil
Pristine β-sitosterol or in combination with other phytosterols is utilized in an array of enriched commercial foods. Considering the presence of β-sitosterol in different functional foods and its potential role in prevention and cure of neurodegenerative diseases, the aims of our investigation were to encapsulate β-sitosterol in nanofibers and to estimate influence of β-sitosterol on proliferation of fibroblasts. Electrospun nanofibers have widely been used as scaffolds to mimic natural extracellular matrix...
December 2, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27884717/activity-based-evaluation-of-a-traditional-ayurvedic-medicinal-plant-saraca-asoca-roxb-de-wilde-flowers-as-estrogenic-agents-using-ovariectomized-rat-model
#2
Gauri Swar, Sunita Shailajan, Sasikumar Menon
ETHNOPHARMACOLOGICAL RELEVANCE: Saraca asoca (Roxb.) de Wilde, Ashok, is a popular traditional plant used for gynecological disorders. In India, the juice of Ashok flowers is traditionally consumed as a tonic by women in case of uterine disorders. But despite the use, its estrogenic potency is not yet evaluated and thus lacks the scientific recognition and acclaim. AIM OF THE STUDY: This study is designed to investigate the estrogenic potential of standardized ethanolic extract of Saraca asoca flowers (SAF) using ovariectomized (OVX) female albino Wistar rat model...
November 21, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27872792/porcine-pancreatic-lipase-inhibitory-agent-isolated-from-medicinal-herb-and-inhibition-kinetics-of-extracts-from-eleusine-indica-l-gaertner
#3
Siew Ling Ong, Siau Hui Mah, How Yee Lai
Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01 ± 5.68% at 100 μg/mL...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27872562/development-of-quality-standards-of-medicinal-mistletoe-helicanthes-elastica-desr-danser-employing-pharmacopoeial-procedures
#4
K N Sunil Kumar, B Ravishankar, B Yashovarma, R Rajakrishnan, J Thomas
Helicanthes elastica (Desr.) Danser (Loranthaceae), commonly known as Indian mango mistletoe, is a parasitic shrub found widely growing on mango trees in southern India. Development of monographic quality standards is need of the hour for Pharmacopoeial/extra-Pharmacopoeial and folk medicinal plants. Systematic pharmacognostical evaluation of leaves of H. elastica has been carried out employing Pharmacopoeial procedures of testing herbal drugs. Macro-microscopic features of H. elastica leaf were recorded. Ethanolic extract was tested positive for alkaloids, steroids, carbohydrates, tannins, saponins and phenols...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27861139/in-vitro-antioxidant-and-anti-inflammatory-activities-of-isolated-compounds-of-ethanol-extract-from-sanchezia-speciosa-leonard-s-leaves
#5
Tung Bui Thanh, Loi Vu Duc, Hai Nguyen Thanh, Vung Nguyen Tien
BACKGROUND: Sanchezia speciosa has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed that S. speciosa contains high amounts of flavonoids and cardiac glycoside compounds. In the present study, we isolated four compounds from the ethanol extract of the S. speciosa leaf, and we evaluated the in vitro antioxidant and anti-inflammatory effect of the isolated compound from the ethanol extract of the S. speciosa leaf. METHODS: The leaf of S...
November 18, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27860471/-constituents-of-the-leaves-of-cornus-officinalis-sieb-et-zucc
#6
Vladimír Forman, Daniel Grančai, Branislav Horváth
The paper deals with the isolation and identification of the constituents of Cornus officinalis Sieb. et Zucc. leaves. There was isolated β-sitosterol from petroleum ether extract, glucose and saccharose from methanolic extract and gallic acid, quercetin and quercetin-3-O-glucoside (isoquercitrin) from aqueous-methanolic extract. Isolates were identified by physico-chemical data, and by comparing with authentic samples and literature data. The compounds I - V were isolated from the leaves of Cornus officinalis Sieb...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27848143/direct-analysis-of-triterpenes-from-high-salt-fermented-cucumbers-using-infrared-matrix-assisted-laser-desorption-electrospray-ionization-ir-maldesi
#7
Måns Ekelöf, Erin K McMurtrie, Milad Nazari, Suzanne D Johanningsmeier, David C Muddiman
High-salt samples present a challenge to mass spectrometry (MS) analysis, particularly when electrospray ionization (ESI) is used, requiring extensive sample preparation steps such as desalting, extraction, and purification. In this study, infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) coupled to a Q Exactive Plus mass spectrometer was used to directly analyze 50-μm thick slices of cucumber fermented and stored in 1 M sodium chloride brine. From the several hundred unique substances observed, three triterpenoid lipids produced by cucumbers, β-sitosterol, stigmasterol, and lupeol, were putatively identified based on exact mass and selected for structural analysis...
November 15, 2016: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/27834099/chemical-composition-and-evaluation-of-prolyl-oligopeptidase-and-acetylcholinesterase-inhibitory-activities-of-leonurus-sibiricus-l-from-brazil
#8
Lucimara L Zachow, Janaína M Ávila, Geovane A Saldanha, Marco A Mostardeiro, Ubiratan F da Silva, Ademir F Morel, Ionara I Dalcol
Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors. Extracts obtained by maceration were active against POP (53-58%), but showed weak activity against AChE...
November 11, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27827864/chemical-constituents-of-muehlenbeckia-tamnifolia-kunth-meisn-polygonaceae-and-its-in-vitro-%C3%AE-amilase-and-%C3%AE-glucosidase-inhibitory-activities
#9
María Torres-Naranjo, Alirica Suárez, Gianluca Gilardoni, Luis Cartuche, Paola Flores, Vladimir Morocho
The phytochemical investigation of Muehlenbeckia tamnifolia, collected in Loja-Ecuador, led to the isolation of nine known compounds identified as: lupeol acetate (1); cis-p-coumaric acid (2); lupeol (3); β-sitosterol (4) trans-p-coumaric acid (5); linoleic acid (6) (+)-catechin (7); afzelin (8) and quercitrin (9). The structures of the isolated compounds were determined based on analysis of NMR and MS data, as well as comparison with the literature. The hypoglycemic activity of crude extracts and isolated compounds was assessed by the ability to inhibit α-amylase and α-glucosidase enzymes...
November 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27821438/akkermansia-muciniphila-improves-metabolic-profiles-by-reducing-inflammation-in-chow-diet-fed-mice
#10
Shaoqian Zhao, Wen Liu, Jiqiu Wang, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Rui-Xin Liu, Jie Hong
Abnormal shifts in the composition of gut microbiota contribute to the pathogenesis of metabolic diseases, including obesity and type 2 diabetes (T2DM). The crosstalk between gut microbes and the host affects the inflammatory status and glucose tolerance of individuals, but the underlying mechanisms have not been elucidated completely. In this study, we treated the lean chow diet-fed mice with Akkermansia muciniphila, which is thought to be inversely correlated with inflammation status and body weight in rodents and humans, and we found that A...
November 7, 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27817202/melicodenine-i-a-new-quinolinone-alkaloid-from-melicope-denhamii-leaves
#11
Sony George, Ramaswamy Venkataraman, Sabulal Baby
A new quinolinone alkaloid, Melicodenine I (1), along with five known compounds, bergapten (2), isoevodionol methyl ether (3), isoevodionol (4), ternatin (5), β-sitosteryl-3-O-β-D-glucopyranoside (6) and a mixture of β-sitosterol and stigmasterol were isolated from Melicope denhamii leaves, and their structures were elucidated using (1)H NMR, (13)C NMR, 2D NMR and UPLC-qToF-MS.
November 6, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27812789/serum-plant-sterols-associate-with-gallstone-disease-independent-of-weight-loss-and-non-alcoholic-fatty-liver-disease
#12
Pirjo Käkelä, Ville Männistö, Imre Ilves, Maija Vaittinen, Milla-Maria Tauriainen, Matti Eskelinen, Helena Gylling, Hannu Paajanen, Jussi Pihlajamäki
BACKGROUND: Gallstone disease (GD) has been associated with low serum levels of plant sterols. We evaluated the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and non-alcoholic fatty liver disease (NAFLD) on the association of GD with low levels of serum plant sterols. METHODS: Two hundred forty-two consecutive morbidly obese patients were recruited to this prospective study. Histological analysis of liver biopsy to diagnose NAFLD was performed. Bile sample was taken during the LRYGB...
November 3, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27794508/antimicrobial-cytotoxic-and-anti-inflammatory-activities-of-pleopeltis-polylepis
#13
Angel V Contreras Cárdenas, Luis R Hernández, Zaida N Juárez, Eugenio Sánchez-Arreola, Horacio Bach
AIM OF THE STUDY: Pleopeltis polylepis (Polypodaceae) is a fern used in the traditional Mexican medicine to treat fever, bleeding, typhoid, cough, pertussis, chest pain, and renal and hepatic diseases. The aim of this study was to analyze the bioactivities of different extracts, fractions and isolated compounds from this species to scientifically validate its medicinal applications. MATERIALS AND METHODS: Aerial parts of P. polylepis were macerated and extracted consecutively with hexane, chloroform, and methanol...
October 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27776459/plant-sterol-enriched-soy-milk-consumption-modulates-5-lipoxygenase-12-lipoxygenase-and-myeloperoxidase-activities-in-healthy-adults-a-randomised-controlled-trial-%C3%A2-%C3%A2
#14
Xing Lin Ho, Jonathan Jia He Liu, Wai Mun Loke
A randomized, double blind, placebo-controlled and crossover study was conducted to simultaneously measure the effects, after 3-hour and 4-week daily exposure to plant sterols-enriched food product, on inflammation, oxidative status, 5-lipoxygenase, 12-lipoxygenase and myeloperoxidase activities in healthy adults. Eighteen healthy participants (67% female, 35.3 (mean)±9.5 (SD) years, mean body mass index 22.8 kg m(-2)) received 2 soy milk (20g) treatments daily: placebo and one containing 2.0g free plant sterols equivalent of their palmitates (β-sitosterol, 55%; campesterol, 29% and stigmasterol, 23%)...
October 24, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27761269/phytochemical-analysis-and-antioxidant-activity-of-salvia-chloroleuca-aerial-extracts
#15
Iraj Salimikia, Hamid Reza Monsef-Esfahani, Ahmad Reza Gohari, Mehrnoosh Salek
BACKGROUND: Salvia, known as Maryam Goli in the Persian language, is an important genus that includes approximately 900 species in the Lamiaceae family. There are 58 Salvia species growing naturally in Iran, including Salvia chloroleuca Rech. f. and Allen., which grows wild in the northeastern and central parts of the country. OBJECTIVES: This study was designed to determine the chemical composition, in vitro antioxidant activity, and total phenol content of various extracts of S...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27761080/free-radical-scavenging-%C3%AE-glucosidase-inhibitory-and-anti-inflammatory-constituents-from-indian-sedges-cyperus-scariosus-r-br-and-cyperus-rotundus-l
#16
Lavanya Kakarla, Suresh Babu Katragadda, Ashok K Tiwari, K Srigiridhar Kotamraju, K Madhusudana, D Anand Kumar, Mahendran Botlagunta
BACKGROUND: Cyperus scariosus R. Br and Cyperus rotundus L are widely used in ayurvedic preparation for the treatment of diabetes and other diseases. The early literature, so far, does not indicate the presence of any bioactive principle isolated from these plants. OBJECTIVE: To identify free radical scavenging, anti-diabetic and anti- inflammatory principles from these two species. MATERIALS AND METHODS: The bioassay guided fractionation and isolation of active constituents was done by chromatographic techniques...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27756154/cryptoporic-acid-s-a-new-drimane-type-sesquiterpene-ether-of-isocitric-acid-from-the-fruiting-bodies-of-cryptoporus-volvatus
#17
Jun-Chi Wang, Guang-Zhi Li, Na Lv, Lian-Gang Shen, Lei-Ling Shi, Jian-Yong Si
A new drimane-type sesquiterpene with an isocitric acid moiety, cryptoporic acid S (1), together with six known compounds, cryptoporic acid D (2), β-sitosterol (3), β-daucosterol (4), stigmast-4-en-3-one (5), ergosterol (6), and (22E,24R)-ergosta-7,22-diene-3β,5α,6β-triol (7), was isolated from the fruiting bodies of Cryptoporus volvatus. The structures of these compounds were established on the basis of UV, IR, MS, 1D and 2D NMR analysis. In the meanwhile, compounds 1 and 2 were evaluated for antioxidant activity using the methods of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (DPPH-RSA) and ferric reducing antioxidant power (FRAP) assay, and they exhibited moderate antioxidant activities...
October 19, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27747875/identification-of-compounds-from-non-polar-fractions-of-blechnum-spp-and-a-multitarget-approach-involving-enzymatic-modulation-and-oxidative-stress
#18
Juliana Maria de Mello Andrade, Natasha Maurmann, Patricia Pranke, Izabel Cristina Casanova Turatti, Norberto Peporine Lopes, Amélia T Henriques
OBJECTIVES: The hexane (HEX) and dichloromethane (DCM) fractions from Blechnum binervatum, Blechnum brasiliense and Blechnum occidentale were studied about phytochemicals and biological properties using multitarget approach. METHODS: The chemical composition was performed by gas chromatography coupled with mass spectrometry detector (GC-MS) analysis. Antioxidant capacity was evaluated against free radicals and on lipid peroxidation. Monoamine oxidases (MAO) and cholinesterases enzymatic modulation, as well as effects on rat and human cells, were assessed...
October 17, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27732901/uvaria-rufa-blume-attenuates-benign-prostatic-hyperplasia-via-inhibiting-5%C3%AE-reductase-and-enhancing-antioxidant-status
#19
Wararut Buncharoen, Kanokporn Saenphet, Supap Saenphet, Chatchote Titaram
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine has used Uvaria rufa Blume as an ethnomedicinal plant for treating fever, skin allergies, intestinal ulcers and prostate disorders including BPH. However, no scientific evidence supports the traditional use. AIM OF THE STUDY: This study aimed to evaluate the therapeutic potential of U. rufa on BPH using in vitro and in vivo models. MATERIALS AND METHODS: In vitro studies screened the efficacy of a 5α-reductase (5αR) inhibition and antioxidant activity of petroleum ether, ethyl acetate, ethanol and aqueous extracts from the stem of U...
October 9, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27731648/phytochemical-constituents-and-biological-activities-of-cleome-iberica-dc
#20
Mahdi Moridi Farimani, Emad Nazarianpoor, Arezoo Rustaie, Maryam Akhbari
Phytochemical investigation of Cleome iberica DC. aerial parts led to the isolation and characterisation of six triterpenoid including glutinol (1), lupeol (2), β-sitosterol (3), cabraleadiol monoacetate (4), cabraleadiol (6) and daucosterol (8), one flavonoid, calycopterin (5) along with a fatty acid, tricosanoic acid (7). While studied samples showed weak potency in antimicrobial assessment, the acetone extract and some isolated compounds exhibited considerable cytotoxicity against cervical cancer cell line (HeLa) in MTT assay, among them calycopterin with IC50 equals to 5...
October 12, 2016: Natural Product Research
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