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https://www.readbyqxmd.com/read/28930139/critical-analysis-on-characterization-systemic-effect-and-therapeutic-potential-of-beta-sitosterol-a-plant-derived-orphan-phytosterol
#1
REVIEW
Muhammad Shahdaat Bin Sayeed, Selim Muhammad Rezaul Karim, Tasnuva Sharmin, Mohammed Monzur Morshed
Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedicine and phytochemistry, and the electronic search included Pubmed, SciFinder, Scopus, the Web of Science, Google Scholar, and others...
November 15, 2016: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28911735/antifungal-activity-of-sterols-and-dipsacus-saponins-isolated-from-dipsacus-asper-roots-against-phytopathogenic-fungi
#2
Nam Hee Choi, Ja Yeong Jang, Gyung Ja Choi, Yong Ho Choi, Kyoung Soo Jang, Van Thu Nguyen, Byung-Sun Min, Quang Le Dang, Jin-Cheol Kim
The in vivo antifungal activity of crude extracts of Dipsacus asper roots was evaluated against the phytopathogenic fungi Botrytis cinerea, Colletotrichum coccodes, Blumeria graminis f. sp. hordei, Magnaporthe grisea, Phytophthora infestans, Puccinia recondita and Rhizoctonia solani using a whole-plant assay method. Ethyl acetate and acetone extracts, at 1000μg/mL, suppressed the development of tomato gray mold (TGM) and tomato late blight (TLB) by 90%. Through bioassay-guided isolation, five antifungal substances were isolated from the D...
September 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28910707/spectral-phasor-analysis-reveals-altered-membrane-order-and-function-of-root-hair-cells-in-arabidopsis-dry2-sqe1-5-drought-hypersensitive-mutant
#3
Florencia Sena, Mariana Sotelo-Silveira, Soledad Astrada, Miguel A Botella, Leonel Malacrida, Omar Borsani
Biological membranes allow the regulation of numerous cellular processes, which are affected when unfavorable environmental factors are perceived. Lipids and proteins are the principal components of biological membranes. Each lipid has unique biophysical properties, and, therefore the lipid composition of the membrane is critical to maintaining the bilayer structure and functionality. Membrane composition and integrity are becoming the focus of studies aiming to understand how plants adapt to its environment...
August 26, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28902635/gc-ms-characterization-of-n-hexane-soluble-fraction-from-dandelion-taraxacum-officinale-weber-ex-f-h-wigg-aerial-parts-and-its-antioxidant-and-antimicrobial-properties
#4
Ivan Ivanov, Nadezhda Petkova, Julian Tumbarski, Ivayla Dincheva, Ilian Badjakov, Panteley Denev, Atanas Pavlov
A comparative investigation of n-hexane soluble compounds from aerial parts of dandelion (Taraxacum officinale Weber ex F.H. Wigg.) collected during different vegetative stages was carried out. The GC-MS analysis of the n-hexane (unpolar) fraction showed the presence of 30 biologically active compounds. Phytol [14.7% of total ion current (TIC)], lupeol (14.5% of TIC), taraxasteryl acetate (11.4% of TIC), β-sitosterol (10.3% of TIC), α-amyrin (9.0% of TIC), β-amyrin (8.3% of TIC), and cycloartenol acetate (5...
September 13, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28902448/synthesis-and-biological-evaluation-of-new-natural-phenolic-2e-4e-6e-octatrienoic-esters
#5
Raffaella Gandolfi, Alessandro Contini, Daniela Pinto, Barbara Marzani, Stefano Pandini, Donatella Nava, Elena Pini
In the present study the esterification of the hydroxyl groups of resveratrol, caffeic acid, ferulic acid and ß-sitosterol with an antioxidant polyconjugated fatty acid, 2E,4E,6E-octatrienoic acid, was achieved. As the selective esterification of hydroxyl groups of natural compounds can affect their biological activity, a selective esterification of resveratrol and caffeic acid was performed by an enzymatic approach. The new resulting compounds were characterized spectroscopically (FT-IR, NMR mono and bidimensional techniques); when necessary the experimental data were integrated by quantum chemical calculations...
September 13, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28899512/nepeta-deflersiana-attenuates-isoproterenol-induced-myocardial-injuries-in-rats-possible-involvement-of-oxidative-stress-apoptosis-inflammation-through-nuclear-factor-nf-%C3%AE%C2%BAb-downregulation
#6
Areej Mohammad Al-Taweel, Mohammad Raish, Shagufta Perveen, Ghada Ahmed Fawzy, Ajaz Ahmad, Mushtaq Ahmad Ansari, Shahid Mudassar, Majid Ahmad Ganaie
BACKGROUND: Nepeta deflersiana (Lamiaceae) is a perennial herb used in the Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. PURPOSE: This study explores the phytochemistry of the plant and the cardioprotective effect of N. deflersiana ethanolic extract (NDEE) against isoproterenol (ISP)-induced myocardial injury in rats. DESIGN/METHODS: Cardiac function, serum cardiac enzymes, myocardial antioxidants, inflammatory, and apoptotic biomarkers, and histopathological parameters were studied in ISP-injured Wistar rat heart tissues...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28888444/metal-ions-accelerated-phytosterol-thermal-degradation-on-ring-a-ring-b-of-steroid-nucleus-in-oils
#7
Yinzhou Hu, Weisu Huang, Maiquan Li, Mengmeng Wang, Yajing Zhao, Tao Xu, Liuquan Zhang, Baiyi Lu, Yan He
This study aimed to investigate the effect of metal ions on the degradation of phytosterols in oils. The oil was heated at 180°C for 1h with/without addition of Fe(3+), Fe(2+), Cu(2+), Mn(2+), Zn(2+), Na(+), Al(3+) and Mg(2+). Variations of β-sitosterol, stigmasterol, campesterol, brassicasterol and their degradation products were confirmed by the GC-MS analysis. In general, the increase of the metal ion concentration resulted in more phytosterol degradation, and the ability of metal ions following decreasing order: Fe(3+)>Fe(2+)>Mn(2+)≥Cu(2+)≥Zn(2+)>Na(+)≥Mg(2+)>Al(3+)...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28885585/hair-regenerative-mechanisms-of-red-ginseng-oil-and-its-major-components-in-the-testosterone-induced-delay-of-anagen-entry-in-c57bl-6-mice
#8
Van-Long Truong, Min Ji Bak, Changook Lee, Mira Jun, Woo-Sik Jeong
Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil (RGO) and its major components on hair re-growth using testosterone (TES)-induced delay of anagen entry in C57BL/6 mice and their mechanisms of action. Seven-week-old C57BL/6 mice were daily treated with TES for 1 h prior to topical application of 10% RGO, 1% linoleic acid (LA), 1% β-sitosterol (SITOS), or 1% bicyclo(10.1.0)tridec-1-ene (BICYCLO) once a day for 28 days...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28868224/characterization-of-acanthosicyos-horridus-and-citrullus-lanatus-seed-oils-two-melon-seed-oils-from-namibia-used-in-food-and-cosmetics-applications
#9
Natascha Cheikhyoussef, Martha Kandawa-Schulz, Ronnie Böck, Charles de Koning, Ahmad Cheikhyoussef, Ahmed A Hussein
The physicochemical characteristics, fatty acid, tocopherol, stigmasterol, β-sitosterol, and (1)H NMR profiles of Citrullus lanatus and Acanthosicyos horridus melon seed oils were determined and compared among different extraction methods (cold pressing, traditional, and Soxhlet). The oil content was 40.2 ± 3.45 and 37.8 ± 7.26% for C. lanatus and A. horridus, respectively. Significant differences (p < 0.05) were observed among the different extraction methods in the characteristics studied. Physicochemical characteristics of the melon seed oils were saponification value, 180...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28859934/acacia-nilotica-leaf-improves-insulin-resistance-and-hyperglycemia-associated-acute-hepatic-injury-and-nephrotoxicity-by-improving-systemic-antioxidant-status-in-diabetic-mice
#10
Manas Ranjan Saha, Priyankar Dey, Indrani Sarkar, Dilip De Sarker, Biswajit Haldar, Tapas Kumar Chaudhuri, Arnab Sen
ETHNOPHARMACOLOGICAL RELEVANCE: Acacia nilotica (L.) Delile is used as a traditional anti-diabetic remedy in Bangladesh, Pakistan, Egypt, Nigeria and is mentioned in Ayurveda as well. AIM: The objective of the study was to evaluate the ethnomedicinal claim of A. nilotica leaf (ANL) extract for its efficiency in ameliorating diabetic complications. MATERIALS AND METHODS: ANL was orally administrated (50 and 200mg/kg) to alloxanized mice (blood glucose > 200mg/dL) for 20d...
August 30, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28857022/phytophthora-pseudopolonica-sp-nov-a-new-species-recovered-from-stream-water-in-subtropical-forests-of-china
#11
Wen-Wen Li, Wen-Xia Zhao, Wen-Xia Huai
A new species of the genus Phytophthora was isolated from stream water in the subtropical forests of China during a survey of forest Phytophthora from 2011 to 2013. This new species is formally described here and named Phytophthora pseudopolonica sp. nov. This new homothallic species is distinct from other known Phytophthora species in morphology and produces nonpapillate and noncaducous sporangia with internal proliferation. Spherical hyphal swellings and thin-walled chlamydospores are abundant when the species is kept in sterile water...
September 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28846663/chemopreventive-potential-of-ethanolic-extracts-of-luobuma-leaves-apocynum-venetum-l-in-androgen-insensitive-prostate-cancer
#12
Szu-Ping Huang, Tzu-Ming Ho, Chih-Wen Yang, Ya-Ju Chang, Jie-Fu Chen, Ning-Sing Shaw, Jia-Cherng Horng, Shih-Lan Hsu, Ming-Yuan Liao, Li-Chen Wu, Ja-An Annie Ho
Luobuma (Apocynum venetum L. (AVL)) is a popular beverage in Asia and has been reportedly to be associated with the bioactivities such as cardiotonic, diuretic, antioxidative, and antihypertensive. However, its biofunction as chemoprevention activity is seldom addressed. Herein, we aimed to characterize the anti-androgen-insensitive-prostate-cancer (anti-AIPC) bioactive compounds of Luobuma, and to investigate the associated molecular mechanisms. Activity-guided-fractionation (antioxidative activity and cell survivability) of Luobuma ethanolic extracts was performed to isolate and characterize the major bioactive compounds using Ultra Performance Liquid Chromatography (UPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and Nuclear Magnetic Resonance (NMR)...
August 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28827970/development-of-validated-high-performance-thin-layer-chromatography-method-for-simultaneous-determination-of-quercetin-and-kaempferol-in-thespesia-populnea
#13
Hiteksha Panchal, Aeshna Amin, Mamta Shah
INTRODUCTION: Thespesia populnea L. (Family: Malvaceae) is a well-known medicinal plant distributed in tropical regions of the world and cultivated in South Gujarat and indicated to be useful in cutaneous affections, psoriasis, ringworm, and eczema. Bark and fruits are indicated in the diseases of skin, urethritis, and gonorrhea. The juice of fruits is employed in treating certain hepatic diseases. The plant is reported to contain flavonoids, quercetin, kaempferol, gossypetin, Kaempferol-3-monoglucoside, β-sitosterol, kaempferol-7-glucoside, and gossypol...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28822155/-chemical-constituents-from-lipophilic-parts-in-roots-of-angelica-dahurica-cv-yubaizhi
#14
Gai-Gai Deng, Xiu-Wei Yang, You-Bo Zhang, Wei Xu, Wei Wei, Zhen-Guo Li
The chemical constituents from lipophilic parts in the roots of Angelica dahurica cv. Yubaizhi were studied in this paper. The compounds were separated and purified by repeated column chromatographic methods on silica gel and HPLC, and the chemical structures of compounds were determined by spectral data analyses. Thirty-three compounds were obtained and identified as isoimperatorin (1), imperatorin (2), stigmasterol (3), isooxypeucedanin (4), pabulenol (5), psoralen (6), bergapten (7), isodemethylfuropinarine (8), phellopterin (9), osthenol (10), alloimperatorin (11), xanthotoxin (12), xanthotoxol (13), isopimpinellin (14), alloisoimperatorin (15), β-sitosterol (16), oxyalloimperatorin (17), pabularinone (18), 5-hydroxy-8-methoxypsoralen (19), columbianetin (20), heracol (21), isogosferol (22), 2″R-neobyakangelicol (23), byakangelicin ethoxide (24), byakangelicin (25), oxypeucedanin hydrate (26), uracil (27), umbelliferone (28), bergaptol (29), demethylfuropinarine (30), isobyakangelicol (31), oxypeucedanin ethanolate (32), heraclenol (33)...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28813102/terpene-esters-from-natural-products-synthesis-and-evaluation-of-cytotoxic-activity
#15
Mauricio M Victor, Jorge M David, Maria C K Sakukuma, Letícia V Costa-Lotufo, Andrea F Moura, Ana J Araújo
Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28812370/rauvolfianine-a-new-antimycobacterial-glyceroglycolipid-and-other-constituents-from-rauvolfia-caffra-sond-apocynaceae
#16
Robert Ebeh Messanga, Ngono Bikobo Dominique Serge, Auguste Abouem A Zintchem, Mbabi Nyemeck Ii Norbert, Moni Ndedi Esther Del Florence, Betote Diboué Patrick Hervé, Nyegue Maximilienne Ascension, Atchadé Alex De Théodore, Pegnyemb Dieudonné Emmanuel, Bochet Christian G, Ulrich Koert
The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4 and 7 were evaluated for antitubercular activity. Compounds 1 and 2 were the most active (MIC = 7...
August 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28812011/oil-characterization-and-lipids-class-composition-of-pomegranate-seeds
#17
Zahra Amri, Houda Lazreg-Aref, Manel Mekni, Sinda El-Gharbi, Olfa Dabbaghi, Beligh Mechri, Mohamed Hammami
This study aims to investigate the physicochemical characteristics, phenolics content, and oil composition of pomegranate oil seeds (PSO). Quality indices, pigments, phenolics content, and antioxidant activity were determined. PSO was fractioned into polar lipids: glycolipids (GL) and phospholipids (PL). Sterols profile and fatty acids composition of total lipids (TL), GL, and PL were determined by GC/FID. The free acidity, the peroxide value, and the specific extinction coefficients were, respectively, 1.69%, 3...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803552/effect-of-acaricidal-components-isolated-from-lettuce-lactuca-sativa-on-carmine-spider-mite-tetranychus-cinnabarinus-boisd
#18
M Li, Y Zhang, W Ding, J Luo, S Li, Q Zhang
This study aimed to evaluate the acaricidal activity of lettuce (Lactuca sativa) extracts against carmine spider mites (Tetranychus cinnabarinus Boisd.) and isolate the acaricidal components. Acaricidal activities of lettuce extracts isolated from different parts (the leaf, root and seed) using various solvents (petroleum ether, acetone and methanol) were evaluated with slide-dip bioassay and relatively high median lethal concentration (LC50) values were detected. Acetone extracts of lettuce leaves harvested in July and September were fractionated and isolated with silica gel and thin-layer chromatography...
August 14, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28801309/determining-the-mechanisms-of-dietary-turnip-rapeseed-oil-on-cholesterol-metabolism-in-men-with-metabolic-syndrome
#19
Harri Juhani Saarinen, Chaiyasit Sittiwet, Piia Simonen, Markku J Nissinen, Ulf-Håkan Stenman, Helena Gylling, Ari Palomäki
We have earlier reported the reduction of total cholesterol, low-density lipoprotein (LDL) cholesterol and oxidized LDL caused by short-term modification of diet with cold-pressed turnip rapeseed oil (CPTRO) instead of butter. The aim of this supplementary study was to determine whether the beneficial effects resulted from altered cholesterol metabolism during the intervention.Thirty-seven men with metabolic syndrome (MetS) completed an open, randomized and balanced crossover study. Subjects' usual diet was supplemented with either 37...
August 11, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28798803/preparation-of-a-nanoemulsion-with-carapa-guianensis-aublet-meliaceae-oil-by-a-low-energy-solvent-free-method-and-evaluation-of-its-preliminary-residual-larvicidal-activity
#20
Flávia L M Jesus, Fernanda B de Almeida, Jonatas L Duarte, Anna E M F M Oliveira, Rodrigo A S Cruz, Raimundo N P Souto, Ricardo M A Ferreira, Regina Gendzelevski Kelmann, José C T Carvalho, Ana C Lira-Guedes, Marcelino Guedes, Conxita Solans, Caio P Fernandes
Andiroba (Carapa guianensis) seeds are the source of an oil with a wide range of biological activities and ethnopharmacological uses. However, few studies have devoted attention to innovative formulations, including nanoemulsions. The present study aimed to obtain a colloidal system with the andiroba oil using a low-energy and organic-solvent-free method. Moreover, the preliminary residual larvicidal activity of the nanoemulsion against Aedes aegypti was evaluated. Oleic and palmitic acids were the major fatty acids, in addition to the phytosterol β-sitosterol and limonoids (tetranortriterpenoids)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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