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https://www.readbyqxmd.com/read/28430910/low-density-lipoprotein-cholesterol-targeting-with-pitavastatin-ezetimibe-for-patients-with-acute-coronary-syndrome-and-dyslipidaemia-the-hij-proper-study-a-prospective-open-label-randomized-trial
#1
Nobuhisa Hagiwara, Erisa Kawada-Watanabe, Ryo Koyanagi, Hiroyuki Arashi, Junichi Yamaguchi, Koichi Nakao, Tetsuya Tobaru, Hiroyuki Tanaka, Toshiaki Oka, Yasuhiro Endoh, Katsumi Saito, Tatsuro Uchida, Kunihiko Matsui, Hiroshi Ogawa
Aims: To elucidate the effects of intensive LDL-C lowering treatment with a standard dose of statin and ezetimibe in patients with dyslipidaemia and high risk of coronary events, targeting LDL-C less than 70 mg/dL (1.8 mmol/L), compared with standard LDL-C lowering lipid monotherapy targeting less than 100 mg/dL (2.6 mmol/L). Methods and Results: The HIJ-PROPER study is a prospective, randomized, open-label trial to assess whether intensive LDL-C lowering with standard-dose pitavastatin plus ezetimibe reduces cardiovascular events more than standard LDL-C lowering with pitavastatin monotherapy in patients with acute coronary syndrome (ACS) and dyslipidaemia...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28430456/the-microstructure-of-%C3%AE-sitosterol-%C3%AE-oryzanol-edible-organogels
#2
Andrew Barclay Matheson, Vasileios Koutsos, Georgios A Dalkas, Stephen Robert Euston, Paul S Clegg
Rheology and atomic force microscopy (AFM) were employed to examine the microstructure of β-sitosterol : γ-oryzanol organogels in sunflower oil. Using time resolved rheology we followed gel formation, paying specific attention to the fibril aggregation process, which had not been studied in detail previously for this system. Using AFM we observed gel structures directly, and obtained detailed information of the gel structure, far exceeding previous studies. Our analysis suggests that though gels are formed by the self-assembly and aggregation of one-dimensional fibrils, the manner in which these fibrils aggregate into ribbons results in complex structures of higher dimensionality...
April 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28428689/experimental-validation-of-antidiabetic-potential-of-cayratia-trifolia-l-domin-an-indigenous-medicinal-plant
#3
Shahid Iqbal Mohammed, Narendra Subhash Salunkhe, Kishor Sukhlal Vishwakarma, Vijay Laxminarayan Maheshwari
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cayratia trifolia root extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes in some parts of India. Ethanolic extract, showing the highest activity in in vitro experiments, was prepared in saline and administered orally to streptozotocin induced albino Wistar diabetic rats for 21 days. Biochemical parameters liver and muscles glycogen and in vivo antioxidant activity in normal, diabetic control, standard (metformin) and treated animals were determined and compared...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428688/modulation-of-angiogenesis-proliferative-response-and-apoptosis-by-%C3%AE-sitosterol-in-rat-model-of-renal-carcinogenesis
#4
Ramalingam Sharmila, Ganapathy Sindhu
As expanded understanding of molecular tumor characteristics, which drive renal cancer growth and progression gives a promising future for renal carcinoma therapy. The objective of the present study was designed to examine the effect of β-sitosterol on a rat model of experimental renal carcinogenesis. Renal carcinogenesis was induced in rats treated with N-diethylnitrosamine (DEN; 200 mg/kg bw single i.p., injection) and ferric nitrilotriacetate (Fe-NTA; 9 mg Fe/kg bw i.p., twice a week for 16 weeks). β-sitosterol pretreatment (20 mg/kg bw in 0...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28420704/influence-of-hdl-particles-on-cell-cholesterol-efflux-under-various-pathological-conditions
#5
Bela F Asztalos, Katalin V Horvath, Michael Mehan, Yuya Yokota, Ernst J Schaefer
It has been reported that low cell-cholesterol efflux capacity (CEC) of HDL is an independent risk factor for CVD. To better understand CEC regulation, we measured ABCA1- and SR-BI-dependent cell-cholesterol efflux, HDL anti-oxidative capacity, HDL particles, lipids, and inflammatory- and oxidative-stress markers in 122 subjects with elevated plasma levels of TG, serum amyloid A (SAA), fibrinogen, myeloperoxidase (MPO), or β-sitosterol and in 146 controls. In controls, there were strong positive correlations between ABCA1-dependent cholesterol efflux and small prebeta-1 concentrations (R2=0...
April 18, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28415422/synthesis-and-characterization-of-redox-sensitive-heparin-%C3%AE-sitosterol-micelles-their-application-as-carriers-for-the-pharmaceutical-agent-doxorubicin-and-investigation-of-their-antimetastatic-activities-in-vitro
#6
Tilahun Ayane Debele, Shewaye Lakew Mekuria, Hsieh-Chih Tsai
Although there are several clinical attempts to treat tumors at the primary site, only few therapies can inhibit the spread of metastatic cancers. In this study, we synthesized redox-sensitive heparin-β-sitosterol micelles that show antimetastatic activity. Proton nuclear magnetic resonance and Fourier transform infrared analyses confirmed the formation of bioreducible heparin-β-sitosterol (bHSC) conjugates, whereas dynamic light scattering was used to measure the particle size and zeta potential. Both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry assays confirmed the low toxicity of the synthesized micelles...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412841/a-new-pyranoxanthone-from-garcinia-nervosa
#7
Ka Woong Wong, Gwendoline Cheng Lian Ee, Intan Safinar Ismail, Thiruventhan Karunakaran, Vivien Yi Mian Jong
Phytochemical studies on the stem bark of Garcinia nervosa has resulted in the discovery of one new pyranoxanthone derivative, garner xanthone (1) and five other compounds, 1,5-dihydroxyxanthone (2), 6-deoxyisojacareubin (3), 12b-hydroxy-des-D-garcigerrin A (4) stigmasterol (5), and β-sitosterol (6). The structures of these compounds were elucidated with the aid of spectroscopic techniques, such as NMR and MS. The crude extracts of the plant were assessed for their antimicrobial activity.
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28403640/a-kaempferol-triglycoside-from-tephrosia-preussii-taub-fabaceae
#8
Yves Martial Mba Nguekeu, Maurice Ducret Awouafack, Pierre Tane, Marius Roch Nguedia Lando, Takeshi Kodama, Hiroyuki Morita
A phytochemical investigation of the MeOH extract of twigs and leaves of Tephrosia preussi was carried out to give a new kaempferol triglycoside, named tephrokaempferoside (1), together with five known compounds: tephrosin (2), betulinic acid (3), lupeol (4), β-sitosterol (5) and 3-O-β-d-glucopyranoside of β-sitosterol (6). The structure of the new compound was characterised by analyses of NMR (1D and 2D) and MS data, and chemical conversion. Tephrokaempferoside (1) had weak antibacterial activity against Klebsiella pneumoniae with an MIC value of 150 μg/mL...
April 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28399868/4-5-4-trihydroxychalcone-8-8-ethene-1-2-diyl-dinaphtalene-1-4-5-triol-and-rutin-from-gynura-segetum-inhibit-phagocytosis-lymphocyte-proliferation-cytokine-release-and-nitric-oxide-production-from-phagocytic-cells
#9
Yuandani, Ibrahim Jantan, Khairana Husain
BACKGROUND: Gynura segetum is used traditionally to treat various ailments related to the immune system, which include cancer, inflammation, rheumatism, diabetes, hypertension, and viral infections but little studies have been carried out to validate their ethnopharmacological aspects. In this study the immunosuppressive effects of G. segetum and its constituents were investigated. METHODS: Isolation of compounds from G. segetum leaves was conducted using vacuum liquid chromatography (VLC) and column chromatography (CC)...
April 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28392458/anti-inflammatory-antimycobacterial-and-genotoxic-evaluation-of-doliocarpus-dentatus
#10
Raissa Borges Ishikawa, Maicon Matos Leitão, Roberto Mikio Kassuya, Luis Fernando Macorini, Flora Martinez Figueira Moreira, Claudia Andrea Lima Cardoso, Roberta Gomes Coelho, Arnildo Pott, Guilherme Martins Gelfuso, Julio Croda, Rodrigo Juliano Oliveira, Candida Aparecida Leite Kassuya
ETHNOPHARMACOLOGICAL RELEVANCE: Doliocarpus dentatus is a medicinal plant widely used in Mato Grosso do Sul State for removing the swelling pain caused by the inflammation process and for treating urine retention. AIM OF THE STUDY: The genotoxic aspects and the anti-inflammatory and antimycobacterial activity of the ethanolic extract obtained from the leaves of D. dentatus (EEDd) were investigated. MATERIALS AND METHODS: The EEDd was evaluated against Mycobacterium tuberculosis, and the compound composition was evaluated and identified by nuclear magnetic resonance (NMR)...
April 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28392375/antibacterial-and-antibiotic-potentiating-activities-of-tropical-marine-sponge-extracts
#11
Rima Beesoo, Ranjeet Bhagooli, Vidushi S Neergheen-Bhujun, Wen-Wu Li, Alexander Kagansky, Theeshan Bahorun
Increasing prevalence of antibiotic resistance has led research to focus on discovering new antimicrobial agents derived from the marine biome. Although ample studies have investigated sponges for their bioactive metabolites with promising prospects in drug discovery, the potentiating effects of sponge extracts on antibiotics still remains to be expounded. The present study aimed to investigate the antibacterial capacity of seven tropical sponges collected from Mauritian waters and their modulatory effect in association with three conventional antibiotics namely chloramphenicol, ampicillin and tetracycline...
April 7, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28384622/a-uhplc-method-for-the-rapid-separation-and-quantification-of-phytosterols-using-tandem-uv-charged-aerosol-detection-a-comparison-of-both-detection-techniques
#12
Jakub Fibigr, Dalibor Šatínský, Petr Solich
The presented work describes the development and validation of a rapid UHPLC-UV/CAD method using a core-shell particle column for the separation and quantitative analysis of seven plant sterols and stanols. The phytosterols (ergosterol, brassicasterol, campesterol, fucosterol, stigmasterol, and β-sitosterol) and the phytostanol stigmastanol were separated and analyzed in 8.5min. The sample pre-treatment procedure was optimized to be less time-consuming than any other published method, especially due to no need of derivatization, evaporation and even reconstitution step...
March 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28382872/association-between-phytosterol-intake-and-colorectal-cancer-risk-a-case-control-study
#13
Jing Huang, Ming Xu, Yu-Jing Fang, Min-Shan Lu, Zhi-Zhong Pan, Wu-Qing Huang, Yu-Ming Chen, Cai-Xia Zhang
A study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case-control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls...
April 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28377207/2-naphthoic-acid-ergosterol-ester-an-ergosterol-derivative-exhibits-anti-tumor-activity-by-promoting-apoptosis-and-inhibiting-angiogenesis
#14
Mingzhu Lin, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang, Guosheng Tang
Phytosterol is a natural component of vegetable oil and includes ergosterol (ER) and β-sitosterol. In this study, three new ergosterol monoester derivatives were obtained from the reflux reaction with ergosterol, organic acids (furoic acid, salicylic acid, and 2-naphthoic acid), EDCI, and DMAP in dichloromethane. The chemical structures were defined by IR and NMR. On the basis of the results, 2-naphthoic acid ergosterol ester (NE) had the highest tumor inhibition rate and was selected to study anti-tumor activity and its mechanism at doses of 0...
April 1, 2017: Steroids
https://www.readbyqxmd.com/read/28372473/selection-of-chemical-markers-for-the-quality-control-of-medicinal-plants-of-the-genus-cecropia
#15
Andrés Rivera-Mondragón, Orlando O Ortíz, Sebastiaan Bijttebier, Arnold Vlietinck, Sandra Apers, Luc Pieters, Catherina Caballero-George
CONTEXT: Several Cecropia (Cecropiaceae) species are traditionally used in Latin America for the treatment of a variety of diseases including diabetes, arterial hypertension, asthma, bronchitis, anxiety, and inflammation. At present, a number of commercial products based on these plants have been introduced into the market with very little information on methods for guaranteeing their quality and safety. OBJECTIVE: This work proposes potential chemical markers for the quality control of the raw materials of Cecropia obtusifolia Bertol...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28367262/an-open-label-evaluator-blinded-study-of-the-efficacy-and-safety-of-a-new-nutritional-supplement-in-androgenetic-alopecia-a-pilot-study
#16
Anna J Nichols, Olivia Bosshardt Hughes, Agnese Canazza, Martin N Zaiac
Objective: To evaluate the effectiveness of a novel oral supplement, Forti5(®), containing green tea extract, omega 3 and 6 fatty acids, cholecalciferol, melatonin, beta-sitosterol, and soy isoflavones, and in the management of subjects with androgenetic alopecia. Design: A prospective case series of 10 subjects. Setting: Open-label, evaluator-blinded, proof-of-concept study. Participants: Ten adult subjects with androgenetic alopecia completed the study. Subjects were not allowed to use oral or topical hair growth products in the 24 weeks preceding the study or during the study...
February 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28362353/ergosteryl-2-naphthoate-an-ergosterol-derivative-exhibits-antidepressant-effects-mediated-by-the-modification-of-gabaergic-and-glutamatergic-systems
#17
Mingzhu Lin, Haijun Li, Yan Zhao, Enbo Cai, Hongyan Zhu, Yugang Gao, Shuangli Liu, He Yang, Lianxue Zhang, Guosheng Tang, Ruiqing Wang
Phytosterols are a kind of natural component including sitosterol, campesterol, avenasterol, ergosterol (Er) and others. Their main natural sources are vegetable oils and their processed products, followed by grains, by-products of cereals and nuts, and small amounts of fruits, vegetables and mushrooms. In this study, three new Er monoester derivatives were obtained from the reflux reaction with Er: organic acids (furoic acid, salicylic acid and 2-naphthoic acid), 1-Ethylethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride (EDCI) and 4-dimethylaminopyridine (DMAP) in dichloromethane...
March 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28356916/spasmolytic-and-antibacterial-activity-of-two-citrus-sinensis-osbeck-varieties-cultivated-in-mexico
#18
Amanda Sánchez-Recillas, Ana Ly Arroyo-Herrera, Jesús Alfredo Araujo-León, Emanuel Hernández Núñez, Rolffy Ortiz Andrade
Antibacterial activity on ATCC strains of Escherichia coli, Salmonella enterica, Salmonella enteritidis, and Salmonella choleraesuis and spasmolytic effect on contraction on rat ileum trips were determinate. Eight organic extracts (hexanic and methanolic) of albedo (mesocarp) and flavedo (pericarp) of two varieties (Valencian and National) of Citrus sinensis (L.) Osbeck of Yucatán, México, were studied. Additionally, chromatographic fingerprints were obtained and correlated with their pharmacological effects...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28347309/chemical-composition-and-pharmacological-activities-of-pisum-sativum
#19
Md Nazmul Hasan Zilani, Tamanna Sultana, S M Asabur Rahman, Md Anisuzzman, Md Amirul Islam, Jamil A Shilpi, Md Golam Hossain
BACKGROUND: Consumption of vegetables has been proven to be effective in the prevention of different diseases. Traditionally edible aerial part of Pisum sativum L. subsp. sativum (Fabaceae) is used to treat diabetes, heart diseases and as blood purifier. Present study was aimed to explore the traditional use of aerial parts of P. sativum as a source of antidiabetic agent. In addition, antioxidant activity and chemical composition was carried out. METHODS: Total polyphenol content was spectrophotometrically determined using Folin Chiocalteu's reagent while the flavonoids by aluminum chloride colorimetric assay...
March 27, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28344474/biologically-guided-isolation-of-leishmanicidal-secondary-metabolites-from-euphorbia-peplus-l
#20
Elham Amin, Abeer Moawad, Hossam Hassan
Leishmaniasis is a worldwide health problem, highly endemic in developing countries. Moreover, the severe side effects and the reported drug resistance make it an urgent need to search for effective drugs that can replace or supplement those currently used. In a research program designed to investigate the antileishmanial activity of plants collected from the Egyptian flora, twenty extracts from fifteen plants growing in Egypt have been investigated for in vitro leishmanicidal activity against Leishmania donovani promastigotes...
February 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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