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https://www.readbyqxmd.com/read/29663929/generation-of-a-graft-versus-anticancer-immune-response-through-skin-allograft-with-tumor
#1
Yuan Fang, Sufang Zhou, Baoshi Zheng, Wenlin Gong, Yong Huang, Zhenghua Zhang, Chaofan Zhou, Huiling Wang, Zhimei Huang, Liping Zhong, Yongxiang Zhao
Effector memory T cells (TEM) are a subset of memory T cells which play an important role in stimulation of adaptive immunity. Although they are associated with multiple immune responses, the antitumor effect of TEM is not clearly understood. In this research, generation of anti-tumor TEM was induced through skin allografts in C57BL/6 mice with B16 melanoma. We observed that the growth of tumor tissues in C57BL/6 mice treated with allografts was interrupted. Furthermore, the survival time for the treated mice was prolonged along with increased serum levels for CXCL9, CXCL10 and INF-γ...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663331/three-cases-of-advanced-cutaneous-angiosarcoma-treated-with-eribulin-investigation-of-serum-soluble-cd163-and-cxcl10-as-possible-biomarkers-predicting-the-biological-behaviour-of-angiosarcoma
#2
T Fujimura, Y Sato, Y Kambayashi, K Tanita, A Tsukada, H Terui, A Hashimoto, S Aiba
Cutaneous angiosarcoma (CAS) is a highly aggressive vascular tumour that recurs locally and metastasizes early. Although chemoradiotherapy with taxanes shows a high response rate with prolonged survival, second-line therapy for advanced CAS remains contentious. This report describes three cases of advanced CAS treated with eribulin. In addition, we investigated serum sCD163, CXCL10 and CCL22 levels at several time points of tumour progression in these patients, revealing serum levels of sCD163 and CXCL10 as potential biomarkers for progression of CAS...
April 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29661181/tlr4-modulates-inflammatory-gene-targets-in-the-retina-during-bacillus-cereus-endophthalmitis
#3
Phillip S Coburn, Frederick C Miller, Austin L LaGrow, Salai Madhumathi Parkunan, C Blake Randall, Rachel L Staats, Michelle C Callegan
BACKGROUND: Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation during endophthalmitis, more rational targets are needed. Toll-like receptors (TLRs) recognize specific motifs on invading pathogens and initiate the innate inflammatory response. We reported that TLR4 contributes to the robust inflammation which is a hallmark of Bacillus cereus endophthalmitis...
April 16, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29659906/increased-chromogranin-a-positive-hormone-negative-cells-in-chronic-pancreatitis
#4
Abu Saleh Md Moin, Megan Cory, Jennifer Choi, Allison Ong, Sangeeta Dhawan, Sarah M Dry, Peter Butler, Robert Rizza, Alexandra Butler
Context: Chronic pancreatitis (CP) is characterized by inflammation, fibrosis and a loss of pancreatic acinar cells which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data has implicated Chromogranin A-positive hormone negative (CPHN) cells as potential evidence of neogenesis in humans. Objective: We sought to establish if CPHN cells were more abundant in chronic pancreatitis in humans...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29649324/a-low-dose-lipid-infusion-is-sufficient-to-induce-insulin-resistance-and-a-pro-inflammatory-response-in-human-subjects
#5
Hanyu Liang, Helen Lum, Andrea Alvarez, Jose de Jesus Garduno-Garcia, Benjamin J Daniel, Nicolas Musi
OBJECTIVE: The root cause behind the low-grade inflammatory state seen in insulin resistant (obesity and type 2 diabetes) states is unclear. Insulin resistant subjects have elevations in plasma free fatty acids (FFA), which are ligands for the pro-inflammatory toll-like receptor (TLR)4 pathway. We tested the hypothesis that an experimental elevation in plasma FFA (within physiological levels) in lean individuals would upregulate TLR4 and activate downstream pathways (e.g., MAPK) in circulating monocytes...
2018: PloS One
https://www.readbyqxmd.com/read/29649237/bronchoalveolar-lavage-bal-cells-in-idiopathic-pulmonary-fibrosis-express-a-complex-pro-inflammatory-pro-repair-angiogenic-activation-pattern-likely-associated-with-macrophage-iron-accumulation
#6
Jungnam Lee, Ivan Arisi, Ermanno Puxeddu, Lazarus K Mramba, Massimo Amicosante, Carmen M Swaisgood, Marco Pallante, Mark L Brantly, C Magnus Sköld, Cesare Saltini
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause characterized by alveolar epithelial damage, patchy interstitial fibrosis and diffuse microvascular abnormalities. In IPF, alveolar clustering of iron-laden alveolar macrophages-a common sign of microhemorrhage, has been associated with vascular abnormalities and worsening of pulmonary hypertension. As iron-dependent ROS generation has been shown to induce unrestrained macrophage activation in disease models of vascular damage, we explored alveolar macrophage activation phenotype in IPF patients (n = 16) and healthy controls (CTR, n = 7) by RNA sequencing of bronchoalveolar lavage (BAL) cells...
2018: PloS One
https://www.readbyqxmd.com/read/29649138/response-of-myeloid-leukemia-cells-to-luteolin-is-modulated-by-differentially-expressed-pituitary-tumor-transforming-gene-1-pttg1-oncoprotein
#7
Pei-Yi Chen, Hsin-Jung Tien, Shih-Fen Chen, Chi-Ting Horng, Huei-Lin Tang, Hui-Ling Jung, Ming-Jiuan Wu, Jui-Hung Yen
Luteolin, a flavonoid nutraceutical abundant in vegetables and fruits, exhibits a wide range of bioactive properties, including antioxidant, anti-inflammatory and anti-cancer activities. Pituitary tumor-transforming gene 1 (PTTG1), an oncoprotein that regulates cell proliferation, is highly expressed in several types of cancer cells including leukemia. In this study, we aim to investigate the anti-cancer effects of luteolin on cells with differential PTTG1 expression and their underlying mechanisms in human myeloid leukemia cells...
April 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29628971/establishment-of-a-chronic-obstructive-pulmonary-disease-mouse-model-based-on-the-elapsed-time-after-lps-intranasal-instillation
#8
Soon-Young Lee, Jin-Ho Cho, Seung Sik Cho, Chun-Sik Bae, Gye-Yeop Kim, Dae-Hun Park
Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finally breathlessness. Recently, anti-COPD drug development has increased, and many animal screening systems have been studied. Tobacco smoke animal models are the best known animal screening system, but have several preparation requirements, such as a tobacco smoke generator and a separate facility to prevent smoke release...
March 2018: Laboratory Animal Research
https://www.readbyqxmd.com/read/29628419/increased-tumor-glycolysis-characterizes-immune-resistance-to-adoptive-t-cell-therapy
#9
Tina Cascone, Jodi A McKenzie, Rina M Mbofung, Simone Punt, Zhe Wang, Chunyu Xu, Leila J Williams, Zhiqiang Wang, Christopher A Bristow, Alessandro Carugo, Michael D Peoples, Lerong Li, Tatiana Karpinets, Lu Huang, Shruti Malu, Caitlin Creasy, Sara E Leahey, Jiong Chen, Yuan Chen, Helen Pelicano, Chantale Bernatchez, Y N Vashisht Gopal, Timothy P Heffernan, Jianhua Hu, Jing Wang, Rodabe N Amaria, Levi A Garraway, Peng Huang, Peiying Yang, Ignacio I Wistuba, Scott E Woodman, Jason Roszik, R Eric Davis, Michael A Davies, John V Heymach, Patrick Hwu, Weiyi Peng
Adoptive T cell therapy (ACT) produces durable responses in some cancer patients; however, most tumors are refractory to ACT and the molecular mechanisms underlying resistance are unclear. Using two independent approaches, we identified tumor glycolysis as a pathway associated with immune resistance in melanoma. Glycolysis-related genes were upregulated in melanoma and lung cancer patient samples poorly infiltrated by T cells. Overexpression of glycolysis-related molecules impaired T cell killing of tumor cells, whereas inhibition of glycolysis enhanced T cell-mediated antitumor immunity in vitro and in vivo...
March 17, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29624878/elastographic-ultrasound-an-additional-image-tool-in-sj%C3%A3-gren-s-syndrome
#10
Eric Kimura-Hayama, Sergio Criales-Vera, Luis Azpeitia-Espinosa, Carlos Pacheco-Molina, Edgardo Reyes, Guadalupe Lima, Diego Hernandez-Ramirez, Luis Llorente, Gabriela Hernandez-Molina
AIM: To evaluate the stiffness of parotid and submandibular glands using elastography ultrasound and to correlate it with B-mode ultrasonographical, clinical and serological features, salivary profibrotic and inflammatory chemokines, and salivary gland fibrosis. METHODS: We performed B-mode and elastography ultrasound of major salivary glands of 26 patients with primary Sjögren's syndrome. We registered the shear wave velocity (SWV) and correlated it with the morphologic ultrasonographic changes assessed by the Hocevar scale...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29615127/inflammatory-licensed-equine-mscs-are-chondroprotective-and-exhibit-enhanced-immunomodulation-in-an-inflammatory-environment
#11
Jennifer M Cassano, Lauren V Schnabel, Margaret B Goodale, Lisa A Fortier
BACKGROUND: Inflammatory licensed mesenchymal stem cells (MSCs) have the ability to promote functional tissue repair. This study specifically sought to understand how the recipient tissue environment reciprocally affects MSC function. Inflammatory polarized macrophages, modeling an injured tissue environment, were exposed to licensed MSCs, and the resultant effects of MSC immunomodulation and functionality of the MSC secretome on chondrocyte homeostasis were studied. METHODS: Inflammatory licensed MSCs were generated through priming with either IFN-γ or polyinosinic:polycytidylic acid (poly I:C)...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29602770/lipocalin-2-plays-an-important-role-in-regulating-inflammation-in-retinal-degeneration
#12
Tanu Parmar, Vipul M Parmar, Lindsay Perusek, Anouk Georges, Masayo Takahashi, John W Crabb, Akiko Maeda
It has become increasingly important to understand how retinal inflammation is regulated because inflammation plays a role in retinal degenerative diseases. Lipocalin 2 (LCN2), an acute stress response protein with multiple innate immune functions, is increased in ATP-binding cassette subfamily A member 4 ( Abca4 ) -/- retinol dehydrogenase 8 ( Rdh8 ) -/- double-knockout mice, an animal model for Stargardt disease and age-related macular degeneration (AMD). To examine roles of LCN2 in retinal inflammation and degeneration, Lcn2-/- Abca4-/- Rdh8-/- triple-knockout mice were generated...
March 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29600327/the-histamine-h4-receptor-modulates-the-differentiation-process-of-human-monocyte-derived-m1-macrophages-and-the-release-of-ccl4-mip-1%C3%AE-from-fully-differentiated-m1-macrophages
#13
Susanne Mommert, Lisanne Ratz, Holger Stark, Ralf Gutzmer, Thomas Werfel
OBJECTIVE: Histamine is an important mediator of biological functions and present in high amounts in inflammatory skin lesions which are characterised by a marked infiltration of myeloid derived cell populations. The aim of the study was to investigate the expression and function of histamine receptors, with a focus on the histamine H4 receptor (H4R) in detail during the differentiation process from monocytes to macrophages and on fully differentiated M1 macrophages. METHODS: Quantitative PCR, ELISA technique, and flow cytometry were applied to analyze expression levels of histamine receptors, of CXCL10, CCL4, CCL3, or IL-23 and of the macrophage differentiation marker CD68, respectively...
March 29, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29588321/pro-tumor-steering-of-cancer-inflammation-by-p50-nf-%C3%AE%C2%BAb-enhances-colorectal-cancer-progression
#14
Chiara Porta, Alessandro Ippolito, Francesca Maria Consonni, Lorenzo Carraro, Giuseppe Celesti, Carmen Correale, Fabio Grizzi, Fabio Pasqualini, Silvia Tartari, Maurizio Rinaldi, Paolo Bianchi, Fiorella Balzac, Stefania Vetrano, Emilia Turco, Emilio Hirsch, Luigi Laghi, Antonio Sica
Although tumor-associated macrophages (TAMs) display a M2-skewed tumor-promoting phenotype in most cancers, in colorectal cancer (CRC), both TAM polarization and its impact remain controversial. We investigated the role of the M2-polarizing p50 NF-κB subunit in orchestrating TAM phenotype, tumor microenvironment composition, and CRC progression. We first demonstrate, by parallel studies in colitis-associated cancer (CAC) and in genetically driven ApcMin mouse models, that the p50-dependent inhibition of M1-polarized gut inflammation supports CRC development...
March 27, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29582477/immune-molecular-profiling-of-whole-blood-drawn-from-a-non-human-primate-cardiac-xenograft-model-treated-with-anti-cd154-monoclonal-antibodies
#15
Sun A Ock, Keon Bong Oh, Seongsoo Hwang, Ik Jin Yun, Curie Ahn, Hyun Ken Chee, Hwajung Kim, Imran Ullah, Gi-Sun Im, Eung Woo Park
Most studies of xenografts have been carried out with complex immunosuppressive regimens to prevent immune rejection; however, such treatments may be fatal owing to unknown causes. Here, we performed immune molecular profiling following anti-CD154 monoclonal antibody (mAb) treatment in heterotopic abdominal cardiac xenografts from α-1,3-galactosyltransferase-knockout pigs into cynomolgus monkeys to elucidate the mechanisms mediating the undesirable fatal side effects of immunosuppressive agents. Blood samples were collected from healthy monkeys as control and then at 2 days after xenograft transplantation and just before humane euthanasia; 94 genes related to the immune system were analyzed...
March 26, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29581408/the-opp-amiacdef-oligopeptide-transporter-mediates-resistance-of-serotype-2-streptococcus-pneumoniae-d39-to-killing-by-chemokine-cxcl10-and-other-antimicrobial-peptides
#16
Kevin E Bruce, Britta E Rued, Ho-Ching Tiffany Tsui, Malcolm E Winkler
Antimicrobial peptides (AMPs), including chemokines, are produced during infections to kill pathogenic bacteria. To fill in gaps about the sensitivities of Streptococcus pneumoniae and related Streptococcus species to chemokines and AMPs, we performed a systematic, quantitative study of inhibition by chemokine CXCL10 and the AMPs, LL-37 and nisin. In a standard Tris-glucose buffer (TGS), all strains assayed lacked metabolic activity, as determined by resazurin (AlamarBlue®) reduction, and were extremely sensitive to CXCL10 and AMPs (IC50 ≈0...
March 26, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29579623/chemokines-and-cancer-new-immune-checkpoints-for-cancer-therapy
#17
REVIEW
Nathan Karin
The current review focuses on two chemokine-chemokine receptor interactions: CXCL10-CXCR3 and CCL1-CCR8. We show that CXCL10 acts on CD4+ and CD8+ T cells to enhance anti-tumor immunity, and explore the translational perspectives of these findings. As for CCR8 very recently, we identified a novel subset of CCR8+CD4+FOXp3+ regulatory T cells (Treg ) that are major drivers of immune regulation. We observed that one of the four CCR8 ligands, CCL1, produced by these cells, potentiates their suppressive activity via induction of CCR8, FOXp3, CD39, Granzyme-B, and IL-10 in a positive feedback mechanism, making them master drivers of immune regulation...
March 23, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29574669/microglia-polarization-and-endoplasmic-reticulum-stress-in-chronic-social-defeat-stress-induced-depression-mouse
#18
Jie Tang, Wenbo Yu, Sheng Chen, Zidan Gao, Baoguo Xiao
Inflammation recently has been considered to be participated in the pathogenesis of major depressive disorder (MDD). However, the detailed mechanism of inflammation in depression has not been completely understood yet. In the present study, depression mice model was established by chronic social defeat stress (CSDS) method and confirmed by behavior examinations including forced swimming test and sucrose preference test. The decrease of spine density and postsynaptic density protein 95 (PSD95) in hippocampus further verified the depression model...
March 24, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29567951/identification-of-potential-key-protein-interaction-networks-of-bk-virus-nephropathy-in-patients-receiving-kidney-transplantation
#19
Linpei Jia, Wenjing Fu, Rufu Jia, Leiyun Wu, Xiaoxia Li, Qiang Jia, Hongliang Zhang
We aim to identify the key protein interaction networks and implicated pathways of BK virus nephropathy (BKVN) via bioinformatic methods. The microarray data GSE75693 of 30 patients with stable kidney transplantation and 15 with BKVN were downloaded and analyzed by using the limma package to identify differentially expressed genes (DEGs). Then the gene ontology (GO) functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were done to investigate the molecular function (MF), biological process (BP), cellular components (CC) and pathways of DEGs...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29563589/higher-levels-of-free-plasma-mitochondrial-dna-are-associated-with-the-onset-of-chronic-gvhd
#20
Jacob Rozmus, Sabine Ivison, Amina Kariminia, Vivian M Leung, Susanna Sung, Peter Subrt, Stephanie J Lee, Eric Boilard, Irwin Walker, Ronan Foley, Jeff Lipton, Geneviève Gallagher, Stephen Couban, Kirk R Schultz
Toll-like receptor-9 (TLR9) responsive B cells have previously been associated with the onset of extensive chronic graft-versus-host disease (cGvHD). We hypothesized that the onset of cGvHD associated with a higher level of plasma-free mitochondrial DNA (mtDNA), a putative TLR9 agonist. Plasma cell-free mtDNA levels were measured in 39 adult patients post-HSCT with and without cGvHD. mtDNA was isolated from plasma and quantified by Q-PCR amplification. We correlated B cell responsiveness to CpG-DNA, a prototypical TLR9 agonist, and previously identified cGVHD biomarkers with mtDNA levels...
March 21, 2018: Bone Marrow Transplantation
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