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Martina Stepankova, Iveta Bartonkova, Eva Jiskrova, Radim Vrzal, Sridhar Mani, Sandhya Kortagere, Zdenek Dvorak
Novel methylindoles were identified as endobiotic and xenobiotic ligands of the human aryl hydrocarbon receptor (AhR). We examined the effects of 22 methylated and methoxylated indoles on the transcriptional activity of AhRs. Employing reporter gene assays in AZ-AHR transgenic cells, we determined full agonist, partial agonist, or antagonist activities of tested compounds, having substantially variable EC50 , IC50 , and relative efficacies. The most effective agonists ( E MAX relative to 5 nM dioxin) of the AhR were 4-Me-indole (134%), 6-Me-indole (91%), and 7-MeO-indole (80%), respectively...
June 2018: Molecular Pharmacology
Daniel G Mulcahy, Justin L Lee, Aryeh H Miller, George R Zug
The taxonomic identity of the Trimeresurus (Popeia) popeiorum complex from the Isthmus of Kra and to the north was investigated. Several studies over the last decade have produced several specimens and associated mtDNA sequence data for a variety of individuals of the T. popeiorum and "T. sabahi" complexes. Here, we combine four mitochondrial genes (12S, 16S, ND4, and CytB) from all available specimens in GenBank with the addition of five new specimens collected from the mainland, Tanintharyi Region of Myanmar...
November 13, 2017: Zootaxa
Hemil Maniar, Harish Kempegowda, Akhil A Tawari, Michael R Rutter, Amrut Borade, Gerard Cush, Daniel S Horwitz
BACKGROUND: The Trimed Medial Malleolar Sled is a newer device designed to treat medial malleolus fracture. The purpose of this study was to compare the outcome of medial malleolar fractures treated with the sled and conventional malleolar screws. METHODS: After obtaining an institutional review board approval, we conducted a retrospective study to identify all skeletally mature patients who sustained an ankle fracture with medial malleolar involvement treated with the sled and we identified a matched cohort treated with conventional malleolar screws...
August 2017: Foot & Ankle Specialist
Raman Mehrzad, David C Kim
BACKGROUND: Distal radius fractures are common, accounting for approximately 18% of all fractures in adults. Operative management is common, and there are numerous variants of plates used. However, data on safety and complication rates for different plates are limited. OBJECTIVE: To determine whether the rate of complications differed between two distinct types of volar plate design for distal radius fracture fixation, one using predetermined fixed angles for the locking screws or pegs and the other using a variable angle locking design for the locking screws or pegs...
December 2016: Annals of Plastic Surgery
Ahmet Altan, İbrahim Damlar, Osman Şahin
PURPOSE: The aim of this study was to compare the nano-hardness and elastic modulus of titanium and resorbable screws and determine whether resorbable screws could completely replace titanium screws. MATERIALS AND METHODS: The mechanical properties (nano-hardness and decreased elastic modulus) of TriMed titanium, resorbable Inion CPS, and Synthes RapidSorb samples were measured using a nano-indentation technique. In this study, a Hysitron TriboIndenter TI 950 with a resolution less than 1 nN and a displacement resolution of 0...
July 2016: Journal of Oral and Maxillofacial Surgery
Shiho Asai, Yukiko Hanzawa, Miki Konda, Daisuke Suzuki, Masaaki Magara, Takaumi Kimura, Ryo Ishihara, Kyoichi Saito, Shinsuke Yamada, Hideyuki Hirota
Microvolume anion-exchange porous polymer disk-packed cartridges were prepared for Am/Np separation, which is required prior to the measurement of Neptunium-237 ((237)Np) with inductively coupled plasma mass spectrometry (ICPMS). Disks with a volume of 0.08 cm(3) were cut out from porous sheets having anion-exchange-group-containing polymer chains densely attached on the pore surface. Four different amine-based groups, N,N-dimethylaminoethyl methacrylate, trimethylammonium, diethylamine, and triethylenediamine (TEDA), were selected as the anion-exchange groups to be introduced into the porous sheets...
March 15, 2016: Analytical Chemistry
Michael P Gaspar, Patrick M Kane, Ralph C Zohn, Taylor Buckley, Sidney M Jacoby, Eon K Shin
PURPOSE: To examine potential risk factors for the development of delayed or nonunion following elective ulnar shortening osteotomy using a dedicated osteotomy plating system. METHODS: We performed a retrospective review of all patients who underwent elective ulnar shortening using the TriMed single osteotomy dynamic compression plating system by 1 of 2 fellowship-trained hand surgeons over a 5-year period. Demographic data and medical, surgical, and social histories were reviewed...
February 2016: Journal of Hand Surgery
Jeannie Huh, Richard R Glisson, Takumi Matsumoto, Mark E Easley
BACKGROUND: Intramedullary screw fixation of fifth metatarsal Jones fractures often produces satisfactory results, however, nonunion and refracture rates are not negligible. The low-profile "hook" plate is an alternative fixation method that has been promoted to offer improved rotational control at the fracture site, but this remains to be proven. The purpose of this study was to document biomechanical performance differences between this type of plate and a contemporary solid, dual-pitch intramedullary screw in a cadaveric Jones fracture model...
April 2016: Foot & Ankle International
Purab Viswanath, Nathan A Monaco, John D Lubahn
Ulnocarpal impingement can be surgically managed with various shortening osteotomy techniques. The purpose of this study was to retrospectively examine the outcomes of the ulnar-shortening osteotomy technique using the Trimed dynamic compression plate (Valencia, California) and to determine whether results vary among patient-related factors, including smoking status, occupation, preoperative diagnosis, and workers' compensation status. Twenty-seven patients (28 wrists) operated by a single surgeon underwent ulnar shortening over a 4-year span...
February 2015: Orthopedics
Feng-Mei Li, Yuan-Yong Feng, Xiao-Ming Jin, Wei Shang
PURPOSE: To discuss the clinical effects of submental island flap on repairing oropharynx defects after cancer ablation, and provide experience for clinical application. METHODS: Thirteen oropharyngeal cancer patients were included, and they were repaired with submental island flaps in oropharynx regions after cancer ablation and radical neck dissection. Among them, 12 patients were squamous cell carcinoma, and 1 patient was carcinoma. RESULTS: Of the 13 flaps used, 12 submental island flaps survived, only 1 flap had partial necrosis at the distal margin, which healed after triming and dressing...
August 2014: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Benjamin Rudnick, Peter Goljan, Jason S Pruzansky, Abdo Bachoura, Sidney M Jacoby, Mark S Rekant
BACKGROUND: Scaphoid excision and four-corner arthrodesis (FCA) is an acceptable motion sparing procedure used to treat wrist arthritis. Recently, a locking dorsal circular plate composed of polyether-ether-ketone has been introduced (Xpode®; TriMed Inc.). The purpose of this study is to assess the efficacy of this specific plate design with regard to FCA. METHODS: A retrospective chart review of all patients who underwent FCA with an Xpode® between January 1, 2008 and December 31, 2012 was conducted...
September 2014: Hand: Official Journal of the American Association for Hand Surgery
H Ian Robins, Mark E Burkard, Richard B Halberg
No abstract text is available yet for this article.
May 2014: Journal of the National Cancer Institute
Michael Pouliot, Jeffrey Yao
Ulnar impaction syndrome (UIS) is a degenerative condition of the ulnar wrist typically seen in patients with static or dynamic ulnar-positive variance. Impaction of the distal ulna on the proximal lunate and triquetrum leads to degeneration of the triangular fibrocartilage complex and/or the chondral surfaces of the lunate and triquetrum. Patients with UIS present with pain in the ulnar aspect of the wrist. In cases of UIS refractory to nonoperative treatment, several surgical techniques have been described, including arthroscopic triangular fibrocartilage complex debridement, arthroscopic wafer procedure, and ulnar shortening osteotomy (USO)...
June 2014: Techniques in Hand & Upper Extremity Surgery
Gregory B Couzens, Susan E Peters, Kenneth Cutbush, Benjamin Hope, Fraser Taylor, Christopher D James, Carly R Rankin, Mark Ross
BACKGROUND: Distal radius fractures are among the most common fractures seen in the hospital emergency department. Of these, over 40% are considered unstable and require some form of fixation. In recent years with the advent of low profile plating, open reduction and internal fixation (ORIF) using volar plates has become the surgical treatment of choice in many hospitals. However, it is currently unknown which plating system has the lowest complication rate and/or superior clinical and radiological outcomes following surgery...
March 11, 2014: BMC Musculoskeletal Disorders
Ling-Yan Zhang, Yan-Jun Liu
A label-free amperometric immunosensor for the detection of methamphetamine was developed. The prussian blue deposited/l-cystine-modified electrode was covered with nano-Au/(3-mercaptorpropyl) trime-thoxysilane film. Then, the nano-Au was used for the immunosensor platform to capture a large amount of anti-methamphetamine. PB exhibited excellent electrocatalytical properties toward the reduction of H2O2 at low overpotentia to amplify the amperometric signal, which enhanced the sensitivity of the immunosensor...
January 2, 2014: Analytica Chimica Acta
Zahab S Ahsan, Yohan Song, Jeffrey Yao
PURPOSE: To evaluate the outcomes of patients with ulnar impaction syndrome treated with a jig-facilitated, oblique, diaphyseal ulnar shortening osteotomy and fixed with a TriMed (Santa Clarita, CA) ulnar osteotomy compression plate. METHODS: A retrospective chart review of patients with ulnar impaction syndrome identified 38 patients who had had ulnar shortening osteotomy and fixation with the TriMed dynamic compression system. The following clinical data were obtained: patient age, sex, follow-up range of motion, grip strength, and complications...
August 2013: Journal of Hand Surgery
Tobin T Eckel, Richard R Glisson, Prashanth Anand, Selene G Parekh
BACKGROUND: Displaced lateral malleolar fractures are often treated with reduction and surgical stabilization. However, there has not been a comprehensive laboratory comparison to determine the most appropriate device for treating these patients. This study subjected a range of contemporary lateral fibular plates to a series of mechanical tests designed to reveal performance differences. METHODS: Forty fresh frozen lower extremities were divided into 4 groups. A Weber B distal fibula fracture was simulated with an osteotomy and stabilized using 1 of 4 plate systems: a standard Synthes one-third tubular plate with interfragmentary lag screw, a Synthes LCP locking plate with lag screw, an Orthohelix MaxLock Extreme low-profile locking plate with lag screw, or a TriMed Sidewinder nonlocking plate...
November 2013: Foot & Ankle International
Tejas Patel, John R Owen, William A Byrd, Ryan B Graves, Ruchi D Chande, Varatharaj Mounasamy, Robert S Adelaar, Jennifer S Wayne
BACKGROUND: Displaced medial malleolus fractures require surgical repair because of the critical role the structure plays in normal joint function. Various approaches exist, but options are limited for small fragment fractures. This study compared repair with the Medial Malleolar Sled fixation system (Trimed, Inc, Valencia, CA) to lag screws in 2 modes of biomechanical loading in a cadaveric model. METHODS: A Müller type B medial malleolus fracture was simulated on matched pairs of cadaveric lower extremities and repaired with the sled or 2 cancellous lag screws...
March 2013: Foot & Ankle International
Tzu-Lun Huang, Chi-Tien Chen
A series of calcium complexes containing oxalamidinate ligands is described. Reactions of oxalamidinate ligand precursors, [PhN=C{NH(CH2)2OMe}-C{NH(CH2)2OMe}=NPh] (1), [PhN=C{NH(CH2)2NMe2}-C{NH(CH2)2NMe2}=NPh] (2), [Ph(TriMe)N=C{NH(CH2)2OMe}-C{NH(CH2)2OMe}=NPh(TriMe)] (3), [Ph(TriMe)N=C{NH(CH2)2SMe}-C{NH(CH2)2SMe}=NPh(TriMe)] (4), [Ph(TriMe)N=C{NHCH2Py}-C{NHCH2Py}=NPh(TriMe)] (5), with two molar equivalents of Ca[N(SiMe3)2]2(THF)2 gave calcium oxalamidinate complexes, [Ca{N(SiMe3)2}(THF)(PhN)C{N(CH2)2OMe}-]2 (6), [Ca{N(SiMe3)2}(THF)(PhN)C{N(CH2)2NMe2}-]2 (7), [Ca{N(SiMe3)2}(THF)(Ph(TriMe)N)C{N(CH2)2OMe}-]2 (8), [Ca{N(SiMe3)2}(THF)(Ph(TriMe)N)C{N(CH2)2SMe}-]2 (9), [Ca{N(SiMe3)2}(THF)(Ph(TriMe)N)C{NCH2Py}-]2 (10), respectively...
July 7, 2013: Dalton Transactions: An International Journal of Inorganic Chemistry
Joon Seon Song, Yong Seok Kim, Dong Kwan Kim, Sung Il Park, Se Jin Jang
Global histone modification patterns are presumed to establish epigenetic patterns of gene expression and determine the biology of the cell. In the present study, the global modification status of histone H3 and H4 was evaluated in 408 non-small cell lung cancer (NSCLC) tissues by immunostaining. NSCLC showed variable staining scores for each antibody. Clinicopathological analyses demonstrated a positive correlation between weak nuclear staining for H3K9Ac (P < 0.001), H3K9TriMe (P= 0.001), H4K16Ac (P < 0...
March 2012: Pathology International
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