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Surveillance, epidemiology end result

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https://www.readbyqxmd.com/read/28748564/medicare-spending-for-breast-prostate-lung-and-colorectal-cancer-patients-in-the-year-of-diagnosis-and-year-of-death
#1
Christopher T Chen, Ling Li, Gabriel Brooks, Michael Hassett, Deborah Schrag
OBJECTIVE: To characterize spending patterns for Medicare patients with incident breast, prostate, lung, and colorectal cancer. DATA SOURCES/STUDY SETTING/STUDY DESIGN: 2007-2012 data from the Surveillance, Epidemiology, and End Results Program linked with Medicare fee-for-service claims. DATA COLLECTION/EXTRACTION METHODS: We calculate per-patient monthly and yearly mean and median expenditures, by cancer type, stage at diagnosis, and spending category, over the years of diagnosis and death...
July 26, 2017: Health Services Research
https://www.readbyqxmd.com/read/28747571/age-specific-sex-difference-in-the-incidence-of-hepatocellular-carcinoma-in-the-united-states
#2
Pian Liu, Shao-Hua Xie, Shaobo Hu, Xiang Cheng, Tianyi Gao, Chen Zhang, Zifang Song
BACKGROUND: Hepatocellular carcinoma possesses a notable sex difference in incidence, and a protective role of estrogens has been hypothesized. METHODS: Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results Program, we describe the age-specific sex difference in the incidence of hepatocellular carcinoma in the United States during 1992-2013. We used a curve fitting by non-linear regression to quantitatively characterize the age-specific incidence rate of hepatocellular carcinoma by sex...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746732/short-term-and-long-term-clinical-outcomes-of-uncommon-types-of-invasive-breast-cancers
#3
Mu Yang, Wei Bao, Xinmin Zhang, Yibin Kang, Bruce Haffty, Lanjing Zhang
BACKGROUND: Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are predominant and well-documented types of invasive breast cancers (IBC). However, clinical outcomes of other types of IBC (i.e., uncommon IBC), which collectively account for about 20% of all IBC cases, are largely unknown. METHODS: We identified all IBC cases diagnosed in 2004-2006 (n=159,293) and 2010-2011 (n=118,822) from the Surveillance, Epidemiology and End Results (SEER) database...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28746700/risk-factors-for-melanoma-in-renal-transplant-recipients
#4
Mona Ascha, Mustafa S Ascha, Joseph Tanenbaum, Jeremy S Bordeaux
Importance: Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. Objective: To determine risk factors and characteristics of renal transplant recipients who develop melanoma. Design, Setting, and Participants: This cohort study of a large national data registry used a cohort of renal transplant recipients from the United States Renal Data System (USRDS) database from the years 2004 through 2012...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28746362/survival-predictors-associated-with-signet-ring-cell-carcinoma-of-the-esophagus-srcce-a-population-based-retrospective-cohort-study
#5
Zihao Wan, Zhihao Huang, Liaobin Chen
PURPOSE: Signet ring cell carcinoma of the esophagus (SRCCE) is an uncommon tumor associated with significant morbidity and mortality. There is still no consensus regarding cut-off values for tumor size, age and optimal treatment for SRCCE. Thus, we elucidated the current survival outcomes of patients with SRCCE and analyzed factors associated with prognosis. METHODS: A retrospective cohort study based on the SEER (The Surveillance, Epidemiology, and End Results) program database was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28745581/clinical-correlates-and-prognostic-value-of-different-metastatic-sites-in-patients-with-malignant-melanoma-of-the-skin-a-seer-database-analysis
#6
Omar Abdel-Rahman
BACKGROUND: Population-based data on the clinical correlates and prognostic value of the pattern of metastases among patients with cutaneous melanoma are needed. METHODS: Surveillance, Epidemiology and End Results (SEER) database (2010-2013) has been explored through SEER*Stat program. For each of six distant metastatic sites (bone, brain, liver, lung, distant lymph nodes, skin/subcutaneous), relevant correlation with baseline characteristics were reported. Survival analysis has been conducted through Kaplan-Meier analysis and multivariate analysis has been conducted through a Cox proportional hazard model...
July 26, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28743940/the-burdens-of-lung-cancer-involved-multiple-primary-cancers-and-its-occurring-patterns-seer-analysis-between-1973-and-2006
#7
Rui Mao, Tao Chen, Fangyu Zhou, Weili Jiang, Xiaorong Yang, Zisheng Ai, Mu Li, Linlin Qin, Long Wang, Ke Fei, Chang Chen
The prognosis of malignancies has improved in recent years, subsequent primary cancers (SPCs) have become more frequent. This study investigates the patterns of lung cancer involved multiple primary cancers. We enrolled 206,619 primary lung cancer patients and 2,071,922 patients with other primary malignancies from Surveillance, Epidemiology and End Results (SEER) database. Observed annual risk (OAR) and absolute numbers were used to describe the risk of SPC and observed cases of SPC per 10,000 person-years at risk...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743236/assessing-the-adequacy-of-lymph-node-yield-for-different-tumor-stages-of-colon-cancer-by-nodal-staging-scores
#8
Zhenyu Wu, Guoyou Qin, Naiqing Zhao, Huixun Jia, Xueying Zheng
BACKGROUND: According to the current official guidelines, at least 12 lymph nodes (LNs) are qualified as an adequate sampling for colon cancer patients. However, patients evaluated with less nodes were still common in the United States, and the prevalence of positive nodal disease may be under-estimated because of the false-negative assessment. In this study, we present a statistical model that allows preoperative determination of the minimum number of lymph nodes needed to confirm a node-negative disease with certain confidence...
July 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28737990/cost-effectiveness-of-novel-agents-in-medicare-patients-with-multiple-myeloma-findings-from-a-u-s-payer-s-perspective
#9
Ying Chen, David R Lairson, Wenyaw Chan, Jinhai Huo, Xianglin L Du
BACKGROUND: Since multiple myeloma (MM) incurs a substantial economic burden in care management, more and more discussion has been generated in recent years about the costs of novel antimyeloma drugs and their associated value. Because of these costs, economic assessment that quantifies value of care over the long-term is essential. OBJECTIVE: To determine the cost-effectiveness (measured as cost per life-year saved) of front-line novel agent-based therapy use among a cohort of elderly patients with MM in a real-world setting...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28735257/prognostic-factors-of-overall-survival-and-cancer-specific-survival-in-patients-with-resected-early-stage-rectal-adenocarcinoma-a-seer-based-study
#10
Ko-Chao Lee, Kuan-Chih Chung, Hong-Hwa Chen, Chia-Cheng Liu, Chien-Chang Lu
The benefits of radiotherapy for colorectal cancer are well documented, but the impact of adjuvant radiotherapy on early-stage rectal adenocarcinoma remains unclear. This study aimed to identify predictors of overall survival (OS) and cancer-specific survival (CSS) in patients with stage II rectal adenocarcinoma treated with preoperative or postoperative radiation therapy. Patients with early-stage rectal adenocarcinoma in the postoperative state were identified using the Surveillance, Epidemiology, and End Results database...
July 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28734542/improved-survival-after-retrieval-of-12-or-more-regional-lymph-nodes-in-appendiceal-cancer
#11
I Fleischmann, R Warschkow, U Beutner, L Marti, B M Schmied, T Steffen
BACKGROUND: To evaluate the role of regional lymph node (RLN) retrieval on stage migration, overall (OS), and cancer-specific survival (CSS) in appendiceal cancer. METHODS: Between 2004 and 2012, 1046 patients with primary stage I-III carcinoma of the appendix were identified in the Surveillance, Epidemiology and End Results database. The impact of the number of RLN removed on OS and CSS was assessed using joinpoint regression, Cox regression, and propensity score methods...
July 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28734019/association-between-androgen-deprivation-therapy-and-anxiety-among-78-000-patients-with-localized-prostate-cancer
#12
Kathryn T Dinh, David D Yang, Kevin T Nead, Gally Reznor, Quoc-Dien Trinh, Paul L Nguyen
OBJECTIVES: To examine whether any androgen deprivation therapy use or longer duration is associated with an increased risk of anxiety in patients with prostate cancer. METHODS: We identified 78 552 men aged ≥66 years with stage I-III prostate cancer using the Surveillance, Epidemiology, and End Results-Medicare linked database from 1992 to 2006, excluding patients with psychiatric diagnoses within the year prior or 6 months after prostate cancer diagnosis. Multivariable Cox regression was used to examine the association between pharmacological androgen deprivation therapy and diagnosis of anxiety...
July 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28733870/rethinking-childhood-ependymoma-a-retrospective-multi-center-analysis-reveals-poor-long-term-overall-survival
#13
Amanda E Marinoff, Clement Ma, Dongjing Guo, Matija Snuderl, Karen D Wright, Peter E Manley, Hasan Al-Sayegh, Claire E Sinai, Nicole J Ullrich, Karen Marcus, Daphne Haas-Kogan, Liliana Goumnerova, Wendy B London, Mark W Kieran, Susan N Chi, Jason Fangusaro, Pratiti Bandopadhayay
Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial ependymoma, who were treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Chicago's Ann & Robert H. Lurie Children's Hospital between 1985 and 2008, and an additional 360 ependymoma patients identified from the Surveillance Epidemiology and End Results (SEER) database...
July 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28733548/the-survival-benefits-of-local-surgery-in-stage-iv-breast-cancer-are-not-affected-by-breast-cancer-subtypes-a-population-based-analysis
#14
San-Gang Wu, Wen-Weng Zhang, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Juan Zhou, Zhen-Yu He
This retrospective study aimed to investigate the clinical value of local surgery in stage IV BC and determined whether the survival outcomes were affected by the breast cancer subtype (BCS). Women with de novo stage IV BC from 2010 to 2013 were included using the Surveillance Epidemiology and End Results database. Univariate and multivariate Cox regression analyses were performed to evaluate the prognostic factors for breast cancer-specific survival (BCSS) and overall survival (OS). Among 9,256 patients were identified, 3,130 (33...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732698/rhabdomyosarcoma-of-the-head-and-neck-impact-of-demographic-and-clinicopathologic-factors-on-survival
#15
Robert J Lee, Kevin K Lee, Thomas Lin, Armin Arshi, Serena A Lee, Russell E Christensen
OBJECTIVE: To determine the survival factors for patients diagnosed with rhabdomyosarcoma of the head and neck. STUDY DESIGN: Data on patients diagnosed with rhabdomyosarcoma of the head and neck between 1973 and 2012 were extracted from the Surveillance, Epidemiology, and End Results database. Kaplan-Meier and Cox proportional hazard regression models were used to determine the demographic characteristics, prognostic factors, and treatment modalities that determine overall survival (OS) and disease-specific survival (DSS)...
May 30, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28732381/lymph-node-ratio-but-not-the-total-number-of-examined-lymph-nodes-or-lymph-node-metastasis-is-a-predictor-of-overall-survival-for-pancreatic-neuroendocrine-neoplasms-after-surgical-resection
#16
Peng Liu, Xianbin Zhang, Yuru Shang, Lili Lu, Fei Cao, Min Sun, Zhaohui Tang, Brigitte Vollmar, Peng Gong
AIM: To evaluate the prognostic significance of lymph node metastasis, extent of examined lymph nodes (ELNs) and lymph node ratio (LNR) for resected pancreatic neuroendocrine neoplasms (pNENs). MATERIALS AND METHODS: Surgically resected pNENs were assimilated from the Surveillance, Epidemiology, and End Results database. Kaplan-Meier and Cox proportional hazard models were used to examine the prognostic effect of clinicopathological characteristics on overall survival; Harrell's concordance index was performed to assess the prognostic accuracy of all independent prognostic factors; and the Spearman's rank correlation was used to assess the correlation between LNR and other clinicopathological characteristics...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732371/the-impacts-of-surgery-of-the-primary-cancer-and-radiotherapy-on-the-survival-of-patients-with-metastatic-rectal-cancer
#17
Duo Tong, Fei Liu, Wenhua Li, Wen Zhang
The role of surgery of the primary cancer and radiation in metastatic colorectal cancer (mCRC) is still controversial currently, and evidence implied that colon cancer (CC) and rectal cancer (RC) should be treated with difference. Hence we focused on metastatic rectal cancer (mRC) solely to compare the cancer cause-specific survival (CSS) of patients receiving varied treatments of the primary cancer: no treatment, surgery only, radiation only, and surgery plus radiation, based on the records of the Surveillance, Epidemiology, and End Results (SEER) database...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28729232/development-feasibility-and-small-scale-implementation-of-a-web-based-prognostic-tool-surveillance-epidemiology-and-end-results-cancer-survival-calculator
#18
Michelle Henton, Bridget Gaglio, Laurie Cynkin, Eric J Feuer, Borsika A Rabin
BACKGROUND: Population datasets and the Internet are playing an ever-growing role in the way cancer information is made available to providers, patients, and their caregivers. The Surveillance, Epidemiology, and End Results Cancer Survival Calculator (SEER*CSC) is a Web-based cancer prognostic tool that uses SEER data, a large population dataset, to provide physicians with highly valid, evidence-based prognostic estimates for increasing shared decision-making and improving patient-provider communication of complex health information...
July 20, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28728748/metastatic-renal-cell-carcinoma-patterns-and-predictors-of-metastases-a-contemporary-population-based-series
#19
Thenappan Chandrasekar, Zachary Klaassen, Hanan Goldberg, Girish S Kulkarni, Robert J Hamilton, Neil E Fleshner
OBJECTIVE: To assess the patterns and predictors of metastatic disease in renal cell carcinoma (RCC) at the time of diagnosis in a contemporary series. METHODS: The Surveillance, Epidemiology, and End Results database was queried for all patients with kidney RCC from 2010 to 2013 (N = 50,815). Distribution and predictors of distant metastases at diagnosis were assessed. Multivariate logistic regression hazard analyses were performed to determine covariates associated with the likelihood of having metastases at diagnosis, whereas competing risks regression analysis was used to assess predictors of cancer-specific mortality (CSM) in patients with metastatic disease...
July 17, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28726159/diagnosis-and-treatment-delays-among-elderly-breast-cancer-patients-with-pre-existing-mental-illness
#20
Kristy Iglay, Melissa L Santorelli, Kim M Hirshfield, Jill M Williams, George G Rhoads, Yong Lin, Kitaw Demissie
PURPOSE: This study aimed to compare diagnosis and treatment delays in elderly breast cancer patients with and without pre-existing mental illness. METHODS: A retrospective cohort study was conducted using the Surveillance, Epidemiology and End Results-Medicare data including 16,636 women 68+ years, who were diagnosed with stage I-IIIa breast cancer in the United States from 2005 to 2007. Mental illness was identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes recorded on inpatient and outpatient claims during the 3 years prior to breast cancer diagnosis...
July 19, 2017: Breast Cancer Research and Treatment
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