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Surveillance, epidemiology end result

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https://www.readbyqxmd.com/read/29340114/survival-benefit-evaluation-of-radiotherapy-in-esophageal-cancer-patients-aged-80-and-older
#1
Shan Huang, Shuyu Zheng, Tuotuo Gong, Hongbing Ma, Yue Ke, Songchuan Zhao, Wenyu Wang, Lijun Jia, Xiaozhi Zhang
Purpose: To evaluate the survival benefit of radiotherapy (RT) in esophageal cancer (EC) patients aged ≥ 80. Materials and Methods: Records for all EC patients aged ≥ 65 years were extracted from the Surveillance, Epidemiology, and End Results database. Chi-square test compared the characteristic and treatment between patients aged ≥ 80 with those aged 65-79. Focusing on patients aged ≥ 80, we employed multivariable logistic regression to identify the association between selection of RT and patients' characteristics...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#2
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29338535/different-lymph-node-staging-systems-for-patients-with-adenocarcinoma-of-esophagogastric-junction
#3
Zhangjian Zhou, Xin Xie, Nan Hao, Dongmei Diao, Yongchun Song, Peng Xia, Chengxue Dang, Hao Zhang
OBJECTIVE: In addition to the traditional TNM N staging system, lymph node ratio (LNR) and log odds of metastatic lymph nodes (LODDS) staging methods were developed in cancers. We aimed to examine their relative prognostic performance in patients with adenocarcinoma of esophagogastric junction (AEG). PATIENTS AND METHODS: Patients who underwent surgical resection for AEG were identified from the Surveillance, Epidemiology, and End Results (SEER) Program and the First Affiliated Hospital of Xi'an Jiaotong University as the training and validation sets, respectively...
January 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29338082/racial-ethnic-differences-in-thyroid-cancer-incidence-in-the-united-states-2007-2014
#4
Kristin S Weeks, Amanda R Kahl, Charles F Lynch, Mary E Charlton
BACKGROUND: Small tumor diagnostic tools including ultrasound-guided fine needle aspiration (FNA) and computed tomography (CT) could be causing rising and racially/ethnically different thyroid cancer incidence rates due to variable overdiagnosis of indolent tumors. Papillary tumors and <40 mm tumors are most likely to be overdiagnosed as indolent tumors by FNA and CT. METHODS: Age-adjusted incidence rates (AAIRs) for the years 2007-2014 were calculated for race/ethnicity (white, Hispanic, Asian, African American, Native American) by patient/tumor characteristics for microscopically confirmed malignant thyroid cancer cases in the Surveillance, Epidemiology, and End Results Program 18 database (SEER 18; N = 93,607)...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29335829/pancreaticoduodenectomy-for-periampullary-tumours-a-review-article-based-on-surveillance-end-results-and-epidemiology-seer-database
#5
REVIEW
S K Kamarajah
INTRODUCTION: This study set to examine relative survival of patients with periampullary cancers undergoing pancreaticoduodenectomy (PD). METHODS: Using the Surveillance, End Results and Epidemiology (SEER) database, this study identified 9877 patients with non-metastatic pancreatic adenocarcinoma who underwent PD between 2004 and 2013. RESULTS: Ampullary carcinomas have the best survival among periampullary malignancies. Lymph node ratio is a significant prognostic factor, even when stratified by tumour types...
January 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29334859/bayesian-analysis-of-semi-parametric-cox-models-with-latent-variables
#6
Jingheng Cai, Chenyi Liang
Respiratory cancer is one of the most commonly diagnosed cancers as well as the leading cause of cancer death. Numerous efforts have been devoted to reducing the death rate of respiratory cancer. In this article, we propose a semi-parametric Cox model with latent variables to assess the effects of observed and latent risk factors on survival time of respiratory cancer. The characteristics of latent risk factors are characterized via multiple observed indicators by a confirmatory factor analysis model. We develop a Bayesian estimation procedure to obtain the estimates of parameters...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29334560/proposed-modification-of-the-8th-edition-of-the-ajcc-staging-system-for-pancreatic-ductal-adenocarcinoma
#7
Si Shi, Jie Hua, Chen Liang, Qingcai Meng, Dingkong Liang, Jin Xu, Quanxing Ni, Xianjun Yu
OBJECTIVE: The aim of this study was to improve the 8th edition (8th) of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: The new 8th AJCC staging system for PDAC was released in October, 2016, and will be applied in clinical practice in 2018. METHODS: Two large cohorts were included in this analysis. One consisted of 45,856 PDAC patients in the Surveillance, Epidemiology, and End Results (SEER) database (2004-2014), and the other consisted of 3166 PDAC patients in the Fudan University Shanghai Cancer Center (FUSCC) database (2005-2015)...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29333596/risk-of-adverse-events-associated-with-front-line-anti-myeloma-treatment-in-medicare-patients-with-multiple-myeloma
#8
Ying Chen, David R Lairson, Wenyaw Chan, Xianglin L Du
This study aims to examine the risks of adverse events associated with anti-multiple myeloma (MM) therapies in a large population-based cohort of elderly patients with MM. Patients diagnosed with advanced MM from 2005 through 2009 and receiving anti-MM therapy were identified from the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked data. We compared safety outcomes between novel agents (proteasome inhibitor (PI) and immunomodulatory drugs (IMiD)) and other therapies and between PI- or IMiD-based regimens and PI plus IMiD combination regimens...
January 15, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29332137/variation-in-guideline-concordant-care-for-elderly-patients-with-metastatic-breast-cancer-in-the-united-states
#9
Philip D Poorvu, Ines Vaz-Luis, Rachel A Freedman, Nancy U Lin, William T Barry, Eric P Winer, Michael J Hassett
PURPOSE: Prior studies have identified shortcomings in the quality of care for early-stage breast cancer. Guidelines recommend systemic therapy for metastatic breast cancer (MBC), but few studies have examined guideline concordance for these patients. METHODS: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data to identify patients aged ≥ 66 diagnosed in 2010-2011 with de novo MBC who were continuously enrolled in fee-for-service Medicare...
January 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29330308/survival-outcomes-of-primary-cutaneous-t-cell-lymphoma-in-hiv-infected-patients-a-national-population-based-study
#10
Jianhong Wang, Rong Liang, Caixia Hao, Xiangxiang Liu, Na Zhang, Xiaohui Duan, Hongjuan Dong, Baoxia Dong, Hongtao Gu, Guangxun Gao, Tao Zhang, Qingxian Bai, Xiequn Chen
This study aimed to investigate clinical characteristics and survival outcomes of primary cutaneous T-cell lymphoma (CTCL) in HIV-infected and non-HIV-infected patients. All data were from the Surveillance, Epidemiology, and End Results program, 1973-2013, of the U.S. National Cancer Institute. Data of 318 HIV-infected patients and 1272 non-HIV-infected patients with primary CTCL were analyzed. Endpoints were overall survival and cancer-specific mortality. Independent variables included demographics, pre-existing malignancy, treatments, and environmental factors...
January 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29330212/early-and-locally-advanced-metaplastic-breast-cancer-presentation-and-survival-by-receptor-status-in-surveillance-epidemiology-and-end-results-seer-2010-2014
#11
Mary C Schroeder, Priya Rastogi, Charles E Geyer, Lance D Miller, Alexandra Thomas
BACKGROUND: Metaplastic breast cancer (MBC) is a rare disease subtype characterized by an aggressive clinical course. MBC is commonly triple negative (TN), although hormone receptor (HR) positive and human epidermal growth receptor 2 (HER2) positive cases do occur. Previous studies have reported similar outcomes for MBC with regard to HR status. Less is known about outcomes for HER2 positive MBC. MATERIALS AND METHODS: Surveillance, Epidemiology, and End Results Program data were used to identify women diagnosed 2010-2014 with MBC or invasive ductal carcinoma (IDC)...
January 12, 2018: Oncologist
https://www.readbyqxmd.com/read/29329160/predictive-effect-of-the-total-number-of-examined-lymph-nodes-on-n-staging-and-survival-in-pancreatic-neuroendocrine-neoplasms
#12
Xianbin Zhang, Lili Lu, Peng Liu, Fei Cao, Yushan Wei, Li Ma, Peng Gong
OBJECTIVES: We aim to examine the predictive effect of the total number of examined lymph nodes on N stage and survival in pancreatic neuroendocrine neoplasms (pNENs) and to determine the optimal threshold. METHODS: A pNENs data set from 2004 to 2013 was extracted from the Surveillance, Epidemiology, and End Result database. Multivariate logistic regression and Cox proportional hazards model were used to identify predictive factors associated with N stage and survival, respectively...
January 12, 2018: Pancreas
https://www.readbyqxmd.com/read/29322826/evaluation-of-the-eighth-american-joint-committee-on-cancer-staging-system-for-malignant-melanoma-of-the-skin
#13
Omar Abdel-Rahman
AIM: To validate the changes among the American Joint Committee on Cancer (AJCC) eighth staging system for cutaneous melanoma. METHODOLOGY: Surveillance, Epidemiology and End Results database (2004-2014) was queried. Kaplan-Meier survival estimates were evaluated according to both AJCC seventh and eighth systems. RESULTS: Overall survival was assessed according to the two editions and p-values for overall trend were significant (p < 0...
January 11, 2018: Future Oncology
https://www.readbyqxmd.com/read/29322643/disparities-in-cancer-outcomes-across-age-sex-and-race-ethnicity-among-patients-with-pancreatic-cancer
#14
Ryan Nipp, Angela C Tramontano, Chung Yin Kong, Pari Pandharipande, Emily C Dowling, Deborah Schrag, Chin Hur
Age, sex, and racial/ethnic disparities exist, but are understudied in pancreatic adenocarcinoma (PDAC). We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to determine whether survival and treatment disparities persist after adjusting for demographic and clinical characteristics. Our study included PDAC patients diagnosed between 1992 and 2011. We used Cox regression to compare survival across age, sex, and race/ethnicity within early-stage and late-stage cancer subgroups, adjusting for marital status, urban location, socioeconomics, SEER region, comorbidities, stage, lymph node status, tumor location, tumor grade, diagnosis year, and treatment received...
January 11, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29318911/comparison-of-three-prognostic-models-for-predicting-cancer-specific-survival-among-patients-with-gastrointestinal-stromal-tumors
#15
Hani Oweira, Jan Schmidt, Arianeb Mehrabi, Hasan Kulaksiz, Paul Schneider, Othmar Schöb, Anwar Giryes, Omar Abdel-Rahman
AIM: To evaluate the predictive value for cancer-specific survival of the models of the American Joint Committee on Cancer (AJCC) stage, NIH and Armed Forces Institute of Pathology (AFIP) among patients with gastrointestinal stromal tumors (GISTs). METHODS: Surveillance, Epidemiology and End Results database (2010-2014) was accessed. Overall survival analysis and adjusted cancer-specific Cox regression hazard was calculated. RESULTS: For gastric GISTs, concordance-index according to AJCC was 0...
January 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29317836/prognosis-of-patients-with-primary-malignant-main-stem-bronchial-tumors-7-418-cases-based-on-the-seer-database
#16
Ke Ma, Fenghao Sun, Xiaodong Yang, Shuai Wang, Lin Wang, Yulin Jin, Yu Shi, Wei Jiang, Cheng Zhan, Qun Wang
Background: The aim of this study was to identify risk factors for patients with malignant main stem bronchial tumors (MBTs) and to develop a nomogram for predicting prognosis in those patients using data from the Surveillance, Epidemiology, and End Results (SEER) database. Method: A process was used for case screening from the SEER database. The effect of prognostic factors on survival was evaluated using the Kaplan-Meier method and log-rank test, a competing risk model, and the Cox proportional hazards regression model...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29316808/impact-of-prior-malignancy-on-outcomes-of-stage-iv-esophageal-carcinoma-seer-based-study
#17
Anas M Saad, Muneer J Al-Husseini, Ahmed Elgebaly, Omar A Aboshady, Sami Salahia, Omar Abdel-Rahman
INTRODUCTION: Usually, clinical trials on esophageal cancer exclude patients with a prior malignancy, assuming that this may influence survival outcomes. However, little is known about the impact of a prior malignancy on its prognosis. METHODOLOGY: The Surveillance, Epidemiology, and End Results database (SEER) was used to review patients with stage IV squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus during 1973-2014. We calculated overall and esophageal cancer-specific survival using unadjusted Kaplan-Meier and multivariable covariate-adjusted Cox models...
January 10, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29314093/hospice-care-in-medicare-patients-with-primary-liver-cancer-the-impact-on-resource-utilisation-and-mortality
#18
N Fukui, P Golabi, M Otgonsuren, L de Avila, H Bush, Z M Younossi
BACKGROUND: Few studies have assessed the impact of hospice care in patients with primary liver cancer. AIM: To examine the determinants of hospice care and its effects on resource utilisation and survival among Medicare beneficiaries with primary liver cancer. METHODS: We utilised the Surveillance, Epidemiology and End result Registry (SEER) database from 2002 to 2009 for this cross-sectional study. A total of 3385 patients with primary liver cancer were included...
January 3, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29313949/cancer-statistics-2018
#19
Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data, available through 2014, were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data, available through 2015, were collected by the National Center for Health Statistics...
January 4, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29312566/trends-in-colorectal-cancer-mortality-in-hispanics-a-seer-analysis
#20
Afsaneh Barzi, Dongyun Yang, Sayedamin Mostofizadeh, Heinz-Josef Lenz
Background: Colorectal cancer (CRC) mortality among Hispanics is lower than Non-Hispanic Whites (NHW). If Hispanics receive equitable care and achieve the same degree of health benefit, their trend of better survival should be maintained. This study assesses mortality trends among Hispanics overtime to compare their survival improvement with NHW. Methods: We used the Incidence-Based Mortality database of the Surveillance, Epidemiology, and End Results Program (SEER) to assess the mortality gap, which is defined as the difference in stage-specific mortality between NHWs and Hispanics, and currently has an advantage for Hispanics...
December 12, 2017: Oncotarget
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