keyword
MENU ▼
Read by QxMD icon Read
search

Critical carr

keyword
https://www.readbyqxmd.com/read/28125659/biodiversity-areas-under-threat-overlap-of-climate-change-and-population-pressures-on-the-world-s-biodiversity-priorities
#1
Juliann E Aukema, Narcisa G Pricope, Gregory J Husak, David Lopez-Carr
Humans and the ecosystem services they depend on are threatened by climate change. Places with high or growing human population as well as increasing climate variability, have a reduced ability to provide ecosystem services just as the need for these services is most critical. A spiral of vulnerability and ecosystem degradation often ensues in such places. We apply different global conservation schemes as proxies to examine the spatial relation between wet season precipitation, population change over three decades, and natural resource conservation...
2017: PloS One
https://www.readbyqxmd.com/read/28125254/is-that-a-human-categorization-dis-fluency-drives-evaluations-of-agents-ambiguous-on-human-likeness
#2
Evan W Carr, Galit Hofree, Kayla Sheldon, Ayse P Saygin, Piotr Winkielman
A fundamental and seemingly unbridgeable psychological boundary divides humans and nonhumans. Essentialism theories suggest that mixing these categories violates "natural kinds." Perceptual theories propose that such mixing creates incompatible cues. Most theories suggest that mixed agents, with both human and nonhuman features, obligatorily elicit discomfort. In contrast, we demonstrate top-down, cognitive control of these effects-such that the discomfort with mixed agents is partially driven by disfluent categorization of ambiguous features that are pertinent to the agent...
January 26, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28116356/tambora-and-the-mackerel-year-phenology-and-fisheries-during-an-extreme-climate-event
#3
Karen E Alexander, William B Leavenworth, Theodore V Willis, Carolyn Hall, Steven Mattocks, Steven M Bittner, Emily Klein, Michelle Staudinger, Alexander Bryan, Julianne Rosset, Benjamin H Carr, Adrian Jordaan
Global warming has increased the frequency of extreme climate events, yet responses of biological and human communities are poorly understood, particularly for aquatic ecosystems and fisheries. Retrospective analysis of known outcomes may provide insights into the nature of adaptations and trajectory of subsequent conditions. We consider the 1815 eruption of the Indonesian volcano Tambora and its impact on Gulf of Maine (GoM) coastal and riparian fisheries in 1816. Applying complex adaptive systems theory with historical methods, we analyzed fish export data and contemporary climate records to disclose human and piscine responses to Tambora's extreme weather at different spatial and temporal scales while also considering sociopolitical influences...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28095684/effect-of-the-protein-corona-on-antibody-antigen-binding-in-nanoparticle-sandwich-immunoassays
#4
Helena de Puig, Irene Bosch, Marc Carré-Camps, Kimberly Hamad-Schifferli
We investigated the effect of the protein corona on the function of nanoparticle (NP) antibody (Ab) conjugates in dipstick sandwich immunoassays. Ab specific for Zika virus nonstructural protein 1 (NS1) were conjugated to gold NPs, and another anti-NS1 Ab was immobilized onto the nitrocellulose membrane. Sandwich immunoassay formation was influenced by whether the strip was run in corona forming conditions, i.e., in human serum. Strips run in buffer or pure solutions of bovine serum albumin exhibited false positives, but those run in human serum did not...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28074831/rgs9-2-modulates-responses-to-oxycodone-in-pain-free-and-chronic-pain-states
#5
Sevasti Gaspari, Valeria Cogliani, Lefteris Manouras, Ethan M Anderson, Vasiliki Mitsi, Kleopatra Avrampou, Fiona B Carr, Venetia Zachariou
Regulator of G protein signalling 9-2 (RGS9-2) is a striatal enriched signal transduction modulator, known to play a critical role in the development of addiction-related behaviours following exposure to psychostimulants or opioids. RGS9-2 controls the function of several GPCRs, including dopamine and mu opioid (MOR) receptors. We previously showed that RGS9-2 complexes negatively control morphine analgesia, and promote the development of morphine tolerance. In contrast, RGS9-2 positively modulates the actions of other opioid analgesics, such as fentanyl and methadone...
January 11, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28071719/quantitative-proteomic-profiling-of-the-extracellular-matrix-of-pancreatic-islets-during-the-angiogenic-switch-and-insulinoma-progression
#6
Alexandra Naba, Karl R Clauser, D R Mani, Steven A Carr, Richard O Hynes
The angiogenic switch, the time at which a tumor becomes vascularized, is a critical step in tumor progression. Indeed, without blood supply, tumors will fail to grow beyond 1 mm(3) and are unlikely to disseminate. The extracellular matrix (ECM), a major component of the tumor microenvironment, is known to undergo significant changes during angiogenesis and tumor progression. However the extent of these changes remains unknown. In this study, we used quantitative proteomics to profile the composition of the ECM of pancreatic islets in a mouse model of insulinoma characterized by a precisely timed angiogenic switch...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27992417/mutations-in-the-histone-methyltransferase-gene-kmt2b-cause-complex-early-onset-dystonia
#7
Esther Meyer, Keren J Carss, Julia Rankin, John M E Nichols, Detelina Grozeva, Agnel P Joseph, Niccolo E Mencacci, Apostolos Papandreou, Joanne Ng, Serena Barral, Adeline Ngoh, Hilla Ben-Pazi, Michel A Willemsen, David Arkadir, Angela Barnicoat, Hagai Bergman, Sanjay Bhate, Amber Boys, Niklas Darin, Nicola Foulds, Nicholas Gutowski, Alison Hills, Henry Houlden, Jane A Hurst, Zvi Israel, Margaret Kaminska, Patricia Limousin, Daniel Lumsden, Shane McKee, Shibalik Misra, Shekeeb S Mohammed, Vasiliki Nakou, Joost Nicolai, Magnus Nilsson, Hardev Pall, Kathryn J Peall, Gregory B Peters, Prab Prabhakar, Miriam S Reuter, Patrick Rump, Reeval Segel, Margje Sinnema, Martin Smith, Peter Turnpenny, Susan M White, Dagmar Wieczorek, Sarah Wiethoff, Brian T Wilson, Gidon Winter, Christopher Wragg, Simon Pope, Simon J H Heales, Deborah Morrogh, Alan Pittman, Lucinda J Carr, Belen Perez-Dueñas, Jean-Pierre Lin, Andre Reis, William A Gahl, Camilo Toro, Kailash P Bhatia, Nicholas W Wood, Erik-Jan Kamsteeg, Wui K Chong, Paul Gissen, Maya Topf, Russell C Dale, Jonathan R Chubb, F Lucy Raymond, Manju A Kurian
Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclear architecture. Despite MLL proteins being postulated as essential for normal development, little is known about the specific functions of the different MLL lysine methyltransferases. Here we report heterozygous variants in the gene KMT2B (also known as MLL4) in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance and characteristic brain magnetic resonance imaging findings...
December 19, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27934002/reversible-transformation-of-pt-nanoparticles-into-single-atoms-inside-high-silica-chabazite-zeolite
#8
Manuel Moliner, Jadeene E Gabay, Chris E Kliewer, Robert T Carr, Javier Guzman, Gary L Casty, Pedro Serna, Avelino Corma
We report the encapsulation of platinum species in highly siliceous chabazite (CHA) crystallized in the presence of N,N,N-trimethyl-1-adamantammonium and a thiol-stabilized Pt complex. When compared to Pt/SiO2 or Pt-containing Al-rich zeolites, the materials in this work show enhanced stability toward metal sintering in a variety of industrial conditions, including H2, O2, and H2O. Remarkably, temperatures in the range 650-750 °C can be reached without significant sintering of the noble metal. Detailed structural determinations by X-ray absorption spectroscopy and aberration-corrected high-angle annular dark-field scanning transmission electron microscopy demonstrate subtle control of the supported metal structures from ∼1 nm nanoparticles to site-isolated single Pt atoms via reversible interconversion of one species into another in reducing and oxidizing atmospheres...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27907062/sepsis-prevalence-and-outcome-on-the-general-wards-and-emergency-departments-in-wales-results-of-a-multi-centre-observational-point-prevalence-study
#9
Tamas Szakmany, Robert M Lundin, Ben Sharif, Gemma Ellis, Paul Morgan, Maja Kopczynska, Amrit Dhadda, Charlotte Mann, Danielle Donoghue, Sarah Rollason, Emma Brownlow, Francesca Hill, Grace Carr, Hannah Turley, James Hassall, James Lloyd, Llywela Davies, Michael Atkinson, Molly Jones, Nerys Jones, Rhodri Martin, Yousef Ibrahim, Judith E Hall
Data on sepsis prevalence on the general wards is lacking on the UK and in the developed world. We conducted a multicentre, prospective, observational study of the prevalence of patients with sepsis or severe sepsis on the general wards and Emergency Departments (ED) in Wales. During the 24-hour study period all patients with NEWS≥3 were screened for presence of 2 or more SIRS criteria. To be eligible for inclusion, patients had to have a high clinical suspicion of an infection, together with a systemic inflammatory response (sepsis) and evidence of acute organ dysfunction and/or shock (severe sepsis)...
2016: PloS One
https://www.readbyqxmd.com/read/27875209/jacobi-fiber-surfaces-for-bivariate-reeb-space-computation
#10
Julien Tierny, Hamish Carr
This paper presents an efficient algorithm for the computation of the Reeb space of an input bivariate piecewise linear scalar function f defined on a tetrahedral mesh. By extending and generalizing algorithmic concepts from the univariate case to the bivariate one, we report the first practical, output-sensitive algorithm for the exact computation of such a Reeb space. The algorithm starts by identifying the Jacobi set of f, the bivariate analogs of critical points in the univariate case. Next, the Reeb space is computed by segmenting the input mesh along the new notion of Jacobi Fiber Surfaces, the bivariate analog of critical contours in the univariate case...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27871682/factors-affecting-mortality-after-penetrating-cardiac-injuries-10-year-experience-at-urban-level-i-trauma-center
#11
Michael J Mina, Rashi Jhunjhunwala, Rondi B Gelbard, Stacy D Dougherty, Jacquelyn S Carr, Christopher J Dente, Jeffrey M Nicholas, Amy D Wyrzykowski, Jeffrey P Salomone, Gary A Vercruysse, David V Feliciano, Bryan C Morse
BACKGROUND: Despite the lethality of injuries to the heart, optimizing factors that impact mortality for victims that do survive to reach the hospital is critical. METHODS: From 2003 to 2012, prehospital data, injury characteristics, and clinical patient factors were analyzed for victims with penetrating cardiac injuries (PCIs) at an urban, level I trauma center. RESULTS: Over the 10-year study, 80 PCI patients survived to reach the hospital...
October 15, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27864051/individual-differences-in-speech-in-noise-perception-parallel-neural-speech-processing-and-attention-in-preschoolers
#12
Elaine C Thompson, Kali Woodruff Carr, Travis White-Schwoch, Sebastian Otto-Meyer, Nina Kraus
From bustling classrooms to unruly lunchrooms, school settings are noisy. To learn effectively in the unwelcome company of numerous distractions, children must clearly perceive speech in noise. In older children and adults, speech-in-noise perception is supported by sensory and cognitive processes, but the correlates underlying this critical listening skill in young children (3-5 year olds) remain undetermined. Employing a longitudinal design (two evaluations separated by ∼12 months), we followed a cohort of 59 preschoolers, ages 3...
February 2017: Hearing Research
https://www.readbyqxmd.com/read/27806266/kinetic-insights-into-the-binding-between-the-nsh3-domain-of-crkii-and-proline-rich-motifs-in-cabl
#13
Danyun Zeng, Veer S Bhatt, Qingliang Shen, Jae-Hyun Cho
The interaction between CrkII and cAbl is implicated in diverse cellular processes. This interaction starts with the binding of the N-terminal Src homology 3 (nSH3) domain of CrkII to the proline-rich motifs of cAbl (PRMs(cAbl)). Despite its critical importance, the detailed binding mechanism between the nSH3 domain and PRMs remains elusive. In this study, we used nuclear magnetic resonance Carr-Purcell-Meiboom-Gill relaxation dispersion experiment to study the binding kinetics between the nSH3 domain of CrkII and PRMs(cAbl)...
November 1, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27743628/controlled-peel-testing-of-a-model-tissue-for-diseased-aorta
#14
Christopher Noble, Nicole Smulders, Roger Lewis, Matt J Carré, Steve E Franklin, Sheila MacNeil, Zeike A Taylor
In this study, we examine the effect of collagenase, elastase and glutaraldehyde treatments on the response of porcine aorta to controlled peel testing. Specifically, the effects on the tissue׳s resistance to dissection, as quantified by critical energy release rate, are investigated. We further explore the utility of these treatments in creating model tissues whose properties emulate those of certain diseased tissues. Such model tissues would find application in, for example, development and physical testing of new endovascular devices...
October 7, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27739880/the-performance-of-hpmc-matrix-tablets-using-various-agglomeration-manufacturing-processes
#15
Darjan Košir, Franc Vrečer
CONTEXT: The flow and compaction properties of a compaction mixture or powder and the drug-release profile of final tablets are important critical quality attributes (CQAs) that have an impact on the overall performance of hydrophilic matrix tablets. The selection of granulation method can importantly affect these CQAs. OBJECTIVE: This study investigates various agglomeration methods of sustained-release formulation using HPMC K4M as a release polymer with various wet- and dry-granulation techniques...
October 14, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27698341/self-amplified-photo-induced-gap-quenching-in-a-correlated-electron-material
#16
S Mathias, S Eich, J Urbancic, S Michael, A V Carr, S Emmerich, A Stange, T Popmintchev, T Rohwer, M Wiesenmayer, A Ruffing, S Jakobs, S Hellmann, P Matyba, C Chen, L Kipp, M Bauer, H C Kapteyn, H C Schneider, K Rossnagel, M M Murnane, M Aeschlimann
Capturing the dynamic electronic band structure of a correlated material presents a powerful capability for uncovering the complex couplings between the electronic and structural degrees of freedom. When combined with ultrafast laser excitation, new phases of matter can result, since far-from-equilibrium excited states are instantaneously populated. Here, we elucidate a general relation between ultrafast non-equilibrium electron dynamics and the size of the characteristic energy gap in a correlated electron material...
October 4, 2016: Nature Communications
https://www.readbyqxmd.com/read/27679663/investigating-what-works-to-support-family-carers-of-people-with-dementia-a-rapid-realist-review
#17
M Parkinson, S M Carr, R Rushmer, C Abley
INTRODUCTION: Advances in longevity and medicine mean that many more people in the UK survive life-threatening diseases but are instead susceptible to life-limiting diseases such as dementia. Within the next 10 years those affected by dementia in the UK is set to rise to over 1 million, making reliance on family care of people with dementia (PWD) essential. A central challenge is how to improve family carer support to offset the demands made by dementia care which can jeopardise carers' own health...
September 27, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/27627129/pbs-nanocrystal-emission-is-governed-by-multiple-emissive-states
#18
Justin R Caram, Sophie N Bertram, Hendrik Utzat, Whitney R Hess, Jessica A Carr, Thomas S Bischof, Andrew P Beyler, Mark W B Wilson, Moungi G Bawendi
Lead chalcogenide colloidal nanocrystals (NCs) are promising materials for solution processable optoelectronics. However, there is little agreement on the identity and character of PbS NC emission for different degrees of quantum confinement-a critical parameter for realizing applications for these nanocrystals. In this work, we combine ensemble and single NC spectroscopies to interrogate preparations of lead sulfide NCs. We use solution photon correlation Fourier spectroscopy (S-PCFS) to measure the average single NC linewidth of near-infrared-emitting PbS quantum dots and find it to be dominated by homogeneous broadening...
October 12, 2016: Nano Letters
https://www.readbyqxmd.com/read/27606232/a-proposed-model-for-selecting-measurement-procedures-for-the-assessment-and-treatment-of-problem-behavior
#19
Linda A LeBlanc, Paige B Raetz, Tyra P Sellers, James E Carr
Practicing behavior analysts frequently assess and treat problem behavior as part of their ongoing job responsibilities. Effective measurement of problem behavior is critical to success in these activities because some measures of problem behavior provide more accurate and complete information about the behavior than others. However, not every measurement procedure is appropriate for every problem behavior and therapeutic circumstance. We summarize the most commonly used measurement procedures, describe the contexts for which they are most appropriate, and propose a clinical decision-making model for selecting measurement produces given certain features of the behavior and constraints of the therapeutic environment...
March 2016: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/27593977/optimized-air-and-investigational-molli-cardiac-t1-mapping-pulse-sequences-produce-similar-intra-scan-repeatability-in-patients-at-3t
#20
KyungPyo Hong, Jeremy Collins, Daniel C Lee, Jane E Wilcox, Michael Markl, James Carr, Daniel Kim
This study was conducted to improve the precision of arrhythmia-insensitive rapid (AIR) cardiac T1 mapping through pulse sequence optimization and then evaluate the intra-scan repeatability in patients at 3T against investigational modified Look-Locker inversion recovery (MOLLI) T1 mapping. In the first development phase (five human subjects), we implemented and tested centric-pair k-space ordering to suppress image artifacts associated with eddy currents. In the second development phase (15 human subjects), we determined optimal flip angles to reduce the measurement variation in T1 maps...
October 2016: NMR in Biomedicine
keyword
keyword
53734
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"