keyword
https://read.qxmd.com/read/38537079/amino-acid-supplementation-confers-protection-to-red-blood-cells-prior-to-plasmodium-falciparum-bystander-stress
#1
JOURNAL ARTICLE
Heather Colvin Binns, Elmira Alipour, Cameron E Sherlock, Dinah S Nahid, John F Whitesides, Anderson O'Brien Cox, Cristina M Furdui, Glen S Marrs, Daniel B Kim-Shapiro, Regina Joice Cordy
Malaria is a highly oxidative parasitic disease in which anemia is the most common clinical symptom. A major contributor to malarial anemia pathogenesis is the destruction of bystander, uninfected red blood cells (RBCs). Metabolic fluctuations are known to occur in the plasma of individuals with acute malaria, emphasizing the role of metabolic changes in disease progression and severity. Here, we report that conditioned media from Plasmodium falciparum culture induces oxidative stress in uninfected, catalase-depleted RBCs...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38537031/anti-biofilm-effectiveness-of-protocols-for-cleaning-complete-dentures-in-hospitalized-patients-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Anna Clara Gurgel Gomes, Janaina Gomes Maciel, Amanda Aparecida Maia Neves Garcia, Letycia Accioly Simões Coelho, Giulia Murcia Rodrigues, Vinicius Carvalho Porto, Grigorios Polyzois, Marlise Inêz Klein, Simone Soares, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek
BACKGROUND: Denture biofilm acts as a potential reservoir for respiratory pathogens, considerably increasing the risk of lung infections, specifically aspiration pneumonia, mainly 48h after hospital admission. The establishment of a straightforward, affordable, and applicable hygiene protocol in a hospital environment for the effective control of denture biofilm can be particularly useful to prevent respiratory infections or reduce the course of established lung disease. OBJECTIVES: To evaluate the anti-biofilm effectiveness of denture cleaning protocols in hospitalized patients...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536847/outcome-of-complicated-osteoarticular-brucellosis-in-a-tertiary-care-center-in-saudi-arabia
#3
JOURNAL ARTICLE
Ebrahim Mahmoud, Areej Alaman, Raghad Alsayari, Anadel Hakeem, Mohammad Bosaeed, Azaheer Ibrahim, Saleh Algazlan, Abdullah Almanea, Ahmed A Abulaban
OBJECTIVE: To evaluate the outcome of complicated osteoarticular brucellosis. METHODS: A retrospective chart review was conducted at King Abdulaziz Medical City (KAMC), in Riyadh, Saudi Arabia. All patients aged more than 14 who have been diagnosed with complicated brucellosis with osteoarticular disease between July 2016 and December 2022 were included. RESULTS: A total of 82 (10.7%) patients met the criteria, with a male predominance of 66 (80...
2024: PloS One
https://read.qxmd.com/read/38536524/clinical-impact-and-cost-consequence-analysis-of-eplex%C3%A2-blood-culture-identification-panels-for-the-rapid-diagnosis-of-bloodstream-infections-a-single-center-randomized-controlled-trial
#4
JOURNAL ARTICLE
Yvan Caspar, A Deves, C Richarme, M Le Marechal, L Ponderand, A-L Mounayar, S Lejeune, J Arata-Bardet, M Gallouche, C Recule, D Maubon, C Garnaud, M Cornet, M Veloso, B Chabani, M Maurin, S David-Tchouda, P Pavese
To assess clinical impact and perform cost-consequence analysis of the broadest multiplex PCR panels available for the rapid diagnosis of bloodstream infections (BSI). Single-center, randomized controlled trial conducted from June 2019 to February 2021 at a French University hospital with an institutional antimicrobial stewardship program. Primary endpoint was the percentage of patients with optimized antimicrobial treatment 12 h after transmission of positivity and Gram stain results from the first positive BC...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536470/a-multicentre-survey-on-the-perception-of-palliative-care-among-health-professionals-working-in-haematology
#5
JOURNAL ARTICLE
Sara Di Lorenzo, Lisa Mozzi, Flavia Salmaso, Claudia Silvagni, Silvia Soffientini, Vanessa Valenti, Vittorina Zagonel
PURPOSE: Patients with haematologic malignancies have less access to palliative care and are referred later than patients with solid tumours. We developed a survey to investigate this phenomenon, with the intention of analysing palliative care perceptions among health professionals who treat haematology patients and identifying barriers and facilitators to referrals to palliative care services. METHODS: This was a multicentre exploratory descriptive web-based survey...
March 27, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38535886/stop-in-time-how-to-reduce-unnecessary-antibiotics-in-newborns-with-late-onset-sepsis-in-neonatal-intensive-care
#6
REVIEW
Domenico Umberto De Rose, Maria Paola Ronchetti, Alessandra Santisi, Paola Bernaschi, Ludovica Martini, Ottavia Porzio, Andrea Dotta, Cinzia Auriti
The fear of missing sepsis episodes in neonates frequently leads to indiscriminate use of antibiotics, and prescription program optimization is suggested for reducing this inappropriate usage. While different authors have studied how to reduce antibiotic overprescription in the case of early onset sepsis episodes, with different approaches being available, less is known about late-onset sepsis episodes. Biomarkers (such as C-reactive protein, procalcitonin, interleukin-6 and 8, and presepsin) can play a crucial role in the prompt diagnosis of late-onset sepsis, but their role in antimicrobial stewardship should be further studied, given that different factors can influence their levels and newborns can be subjected to prolonged therapy if their levels are expected to return to zero...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535577/-staphylococcus-capitis-central-line-associated-bloodstream-infections-in-the-neonatal-intensive-care-unit-a-single-center-four-year-experience-in-central-line-management-during-sepsis-treatment
#7
JOURNAL ARTICLE
Anna Sala, Valentina Pivetti, Alessandra Vittorini, Claudia Viggiano, Francesca Castoldi, Valentina Fabiano, Gianluca Lista, Francesco Cavigioli
Coagulase-negative staphylococci (CoNS) are reportedly responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in neonatal intensive care units (NICUs). Staphylococcus capitis is an increasingly prevalent pathogen in the neonatal setting, frequently causing central-line-associated bloodstream infections (CLABSIs) that can be difficult to eradicate. Central venous catheter (CVC) removal versus in situ treatment with CoNS CLABSIs is a controversial treatment strategy with no clear consensus...
March 7, 2024: Pathogens
https://read.qxmd.com/read/38535058/periportal-edema-as-an-extrarenal-manifestation-of-acute-pyelonephritis
#8
JOURNAL ARTICLE
Yu-Yun Chang, Kuei-Hong Kuo
Acute pyelonephritis is a common infection of the upper urinary tract that affects approximately 250,000 adults in the United States. Individuals with acute pyelonephritis require hospitalization and intravenous antimicrobial therapy. Diagnoses of acute pyelonephritis are made on the basis of clinical and laboratory findings. Individuals with complex or severe acute pyelonephritis undergo contrast-enhanced computed tomography (CT) for the diagnosis and assessment of perirenal abnormalities. However, extrarenal manifestations, such as periportal edema and gallbladder wall thickening, may complicate the diagnostic process...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38534719/antimicrobial-treatment-challenges-in-the-management-of-infective-spondylodiscitis-associated-with-hemodialysis-a-comprehensive-review-of-literature-and-case-series-analysis
#9
JOURNAL ARTICLE
Ioana A Ratiu, Corina F Moisa, Laura Țiburcă, Edy Hagi-Islai, Anamaria Ratiu, Gabriel Cristian Bako, Cristian Adrian Ratiu, Liana Stefan
Infective spondylodiscitis (ISD), the infection of vertebral bodies and surrounding tissues, is a rare complication with major impact on the long-term survival of hemodialysis (HD) patients. Although the most frequent etiology is staphylococcal , identifying these pathogens in blood cultures and biopsy cultures is often difficult. This paper aims to present suitable antibiotic combinations for the treatment of these patients, which is usually challenging in the case of an unidentified pathogen. We presented the therapies applied for 13 HD patients and 19 patients without chronic kidney disease (CKD), diagnosed with ISD between 2013 and 2023 in Bihor County...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#10
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38534685/an-overview-of-antibiotic-therapy-for-early-and-late-onset-neonatal-sepsis-current-strategies-and-future-prospects
#11
REVIEW
Giovanni Boscarino, Rossana Romano, Carlotta Iotti, Francesca Tegoni, Serafina Perrone, Susanna Esposito
Neonatal sepsis is a clinical syndrome mainly associated with a bacterial infection leading to severe clinical manifestations that could be associated with fatal sequalae. According to the time of onset, neonatal sepsis is categorized as early- (EOS) or late-onset sepsis (LOS). Despite blood culture being the gold standard for diagnosis, it has several limitations, and early diagnosis is not immediate. Consequently, most infants who start empirical antimicrobial therapy do not have an underlying infection. Despite stewardship programs partially reduced this negative trend, in neonatology, antibiotic overuse still persists, and it is associated with several relevant problems, the first of which is the increase in antimicrobial resistance (AMR)...
March 10, 2024: Antibiotics
https://read.qxmd.com/read/38534681/the-use-of-chromid-%C3%A2-colistin-r-for-the-detection-of-colistin-resistant-gram-negative-bacteria-in-positive-blood-cultures
#12
JOURNAL ARTICLE
Emma C L Marrs, Olivia Milburn, Gary J Eltringham, Danielle J C Fenwick, Sylvain Orenga, Gulsen Hazırolan, Pinar Zarakolu, John D Perry
The aim of this study was to assess the utility of CHROMID® Colistin R for direct detection of colistin-resistant Gram-negative bacteria from positive blood cultures. A total of 390 blood cultures from hospitalised patients containing Gram-negative bacteria were included in this study. These blood cultures were referred to clinical laboratories in the United Kingdom and Türkiye. A further 16 simulated positive blood culture bottles were included that contained a range of colistin-resistant strains as well as susceptible control strains...
March 7, 2024: Antibiotics
https://read.qxmd.com/read/38534666/rapid-phenotypic-antibiotic-susceptibility-profiling-of-clinical-escherichia-coli-and-klebsiella-pneumoniae-blood-cultures
#13
JOURNAL ARTICLE
Idan Hefetz, Rita Bardenstein, Shahar Rotem, Galia Zaide, Gal Bilinsky, Ohad Shifman, Oren Zimhony, Ronit Aloni-Grinstein
Bloodstream infections (BSI) are defined by the presence of viable bacteria or fungi, accompanied by systemic signs of infection. Choosing empirical therapy based solely on patient risk factors and prior antibiotic susceptibility test (AST) may lead to either ineffective treatment or unnecessarily broad-spectrum antibiotic exposure. In general, Clinical & Laboratory Standards Institute guideline-approved ASTs have a turnaround time of 48-72 h from sample to answer, a period that may result in a critical delay in the appropriate selection of therapy...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534649/the-impact-of-covid-19-on-multidrug-resistant-bacteria-at-a-slovenian-tertiary-medical-center
#14
JOURNAL ARTICLE
Tatjana Mrvič, Sintija Stevanoska, Bojana Beović, Mateja Logar, Sergeja Gregorčič, Benica Žnidaršič, Katja Seme, Ivana Velimirović, Nataša Švent Kučina, Polona Maver Vodičar, Veronika Križan Hergouth, Sašo Džeroski, Mateja Pirs
The COVID-19 pandemic has strained healthcare systems globally. Shortages of hospital beds, reassignment of healthcare workers to COVID-19-dedicated wards, an increased workload, and evolving infection prevention and control measures have potentially contributed to the spread of multidrug-resistant bacteria (MDRB). To determine the impact of the COVID-19 pandemic at the University Medical Center Ljubljana, a tertiary teaching hospital, we analyzed the monthly incidence of select bacterial species per patient from 2018 to 2022...
February 23, 2024: Antibiotics
https://read.qxmd.com/read/38534636/comparative-assessment-of-the-antibacterial-and-antibiofilm-actions-of-benzalkonium-chloride-erythromycin-and-l-lactic-acid-against-raw-chicken-meat-campylobacter-spp-isolates
#15
JOURNAL ARTICLE
Dimitra Kostoglou, Athina Vass, Efstathios Giaouris
Campylobacter spp. are significant zoonotic agents, which cause annually millions of human cases of foodborne gastroenteritis worldwide. Their inclusion in biofilms on abiotic surfaces seems to play a pivotal role in their survival outside of the host, growth, and spread. To successfully mitigate the risks that arise with these bacteria, it is crucial to decrease their prevalence within the food production chain (from farm to the table), alongside the successful treatment of the resulting illness, known as campylobacteriosis...
February 21, 2024: Antibiotics
https://read.qxmd.com/read/38534380/fluvastatin-converts-human-macrophages-into-foam-cells-with-increased-inflammatory-response-to-inactivated-mycobacterium-tuberculosis-h37ra
#16
JOURNAL ARTICLE
María Teresa Montero-Vega, Joaquín Matilla, Eulalia Bazán, Diana Reimers, Ana De Andrés-Martín, Rafael Gonzalo-Gobernado, Carlos Correa, Francisco Urbano, Diego Gómez-Coronado
Cholesterol biosynthesis inhibitors (statins) protect hypercholesterolemic patients against developing active tuberculosis, suggesting that these drugs could help the host to control the pathogen at the initial stages of the disease. This work studies the effect of fluvastatin on the early response of healthy peripheral blood mononuclear cells (PBMCs) to inactivated Mycobacterium tuberculosis (Mtb) H37Ra . We found that in fluvastatin-treated PBMCs, most monocytes/macrophages became foamy cells that overproduced NLRP3 inflammasome components in the absence of immune stimulation, evidencing important cholesterol metabolism/immunity connections...
March 18, 2024: Cells
https://read.qxmd.com/read/38534130/trichothecenes-with-cytotoxic-activity-and-benzene-derivatives-with-hypolipidemic-activity-from-trichothecium-sp
#17
JOURNAL ARTICLE
An-An Yang, Yi-Fan Guo, Ke-Ran Hao, Yi-Ting Wu, Liang Xing
Five trichothecenes including a new one, together with two previously undescribed benzene derivatives were isolated from the solid culture of Trichothecium sp. Their structures were established by 1D and 2D NMR data in conjunction with HR-ESI-MS analysis. Compounds 1-5 exhibited cytotoxicity against MCF-7 cell lines at various levels ranging from IC50 of 7.23 to 16.95  μ M. Compound 6 decreased the concentration of blood lipids in zebra fish at the concentration of 20  μ M.
March 27, 2024: Natural Product Research
https://read.qxmd.com/read/38533793/implementation-of-a-minimally-invasive-cell-culture-system-to-measure-the-regulation-of-inflammation-in-a-school-based-sample-of-adolescents
#18
JOURNAL ARTICLE
Thomas W McDade, Matteo Giletta, Aaron A Miller, Keegan C Krause, Nathalie Michels
Dysregulated inflammation underlies many human diseases, and measures of responsiveness to activation, and sensitivity to inhibition, provide important information beyond baseline assessments of chronic inflammation. This study implements a simplified cell culture protocol in a school-based setting, using finger stick capillary blood collected from 333 adolescents (age 11.4-15.6 years) incubated with lipopolysaccharide (LPS). Median cytokine responses for IL6, IL1β, and TNFα were 61.9, 26...
March 27, 2024: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://read.qxmd.com/read/38533604/artificial-vascular-with-pressure-responsive-property-based-on-deformable-microfluidic-channels
#19
JOURNAL ARTICLE
Zhenlin Chen, Lei Fan, Shuxun Chen, Han Zhao, Qiang Zhang, Yun Qu, Ya Huang, Xinge Yu, Dong Sun
In vitro blood vessel models are significant for disease modeling, drug assays, and therapeutic development. Microfluidic technologies allow creating physiologically relevant culture models reproducing the features of the in vivo vascular microenvironment. However, current microfluidic technologies are limited by impractical rectangular cross-sections and single or nonsynchronous compound mechanical stimuli. This study proposes a new strategy for creating round-shaped deformable soft microfluidic channels to serve as artificial in vitro vasculature for developing in vitro models with vascular physio-mechanical microenvironments...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38533504/interaction-between-peripheral-blood-mononuclear-cells-and-trypanosoma-cruzi-infected-adipocytes-implications-for-treatment-failure-and-induction-of-immunomodulatory-mechanisms-in-adipose-tissue
#20
JOURNAL ARTICLE
Leyllane Rafael Moreira, Ana Carla Silva, Cíntia Nascimento da Costa-Oliveira, Claudeir Dias da Silva-Júnior, Kamila Kássia Dos Santos Oliveira, Diego José Lira Torres, Michelle D Barros, Michelle Christiane D S Rabello, Virginia Maria Barros de Lorena
BACKGROUND/INTRODUCTION: Adipose tissue (AT) has been highlighted as a promising reservoir of infection for viruses, bacteria and parasites. Among them is Trypanosoma cruzi , which causes Chagas disease. The recommended treatment for the disease in Brazil is Benznidazole (BZ). However, its efficacy may vary according to the stage of the disease, geographical origin, age, immune background of the host and sensitivity of the strains to the drug. In this context, AT may act as an ally for the parasite survival and persistence in the host and a barrier for BZ action...
2024: Frontiers in Immunology
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