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https://www.readbyqxmd.com/read/28222575/the-effect-of-pacing-strategy-on-physiological-kinetic-and-performance-variables-during-simulated-rowing-ergometer
#1
Eleni Dimakopoulou, Elias Zacharogiannis, Chrysoula Chairopoulou, Socratis Kaloupsis, Theodoros Platanou
BACKGROUND: This study compared the effects of self selected (SSP), negative (NPS) and even (EPS) pacing strategy on performance time, kinetic and physiological variables in overall 2km rowing and in first and second 1km. METHODS: Fifteen male rowers (15.37 ± 1.34 yrs) realized four tests: an incremental test on a rowing ergometer to determine their VO2peak and three experimental 2 km rowing race, where first 1km was manipulated. From SSP a negative pacing strategy, 4% slower than the mean velocity of SSP, and an even pacing strategy (EPS) with mean velocity of SSP, were developed...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28222565/carbon-modular-orthosis-ca-m-o-an%C3%A2-innovative-hybrid-modular-ankle-foot-orthosis-to-tune-the-variable-rehabilitation-needs-in-hemiplegic-cerebral-palsy
#2
E Tavernese, M Petrarca, G Rosellini, E Di Stanislao, A Pisano, G Di Rosa, E Castelli
BACKGROUND: Hemiplegic Celebral Palsy (CP) children commonly use AFO orthoses as walking aids. It is known that AFOs may have a detrimental effect on gait. To enhance mechanical properties of AFOs we developed an innovative, custom-made, carbon, ankle-foot orthosis (Ca.M.O) which offers the opportunity to tune its response to the patient's gait characteristics and/or functional maturity. OBJECTIVE: To assess the efficacy of Ca.M.O. in improving gait in a group of hemiplegic CP children and to compare its performances with those of commonly prescribed AFO...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#3
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222511/evaluation-of-a-dna-a%C3%AE-42-vaccine-in-aged-nzw-rabbits-antibody-kinetics-and-immune-profile-after-intradermal-immunization-with-full-length-dna-a%C3%AE-42-trimer
#4
Doris Lambracht-Washington, Min Fu, Mary Wight-Carter, Matthew Riegel, Roger N Rosenberg
A pathological hallmark of Alzheimer's disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222373/phytochelatins-play-key-roles-for-the-difference-in-root-arsenic-accumulation-of-different-triticum-aestivum-cultivars-in-comparison-with-arsenate-uptake-kinetics-and-reduction
#5
Gao Ling Shi, Lai Qing Lou, Dao Jun Li, Zhu Bing Hu, Qing Sheng Cai
In the previous studies, we have found that arsenic (As) accumulation in roots of bread wheat (Triticum aestivum L.) seedlings were significantly different among different wheat cultivars, and As(V) tolerant wheat cultivars have much higher capacities of root As accumulation. However, the reason for the difference remains unclear. Four wheat cultivars with high (MM45 and FM8) or low (QF1 and HM29) levels of arsenic (As) accumulation were selected to investigate the relationship between root As(V) uptake kinetics and root As accumulation...
February 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28222371/remediating-1-4-dioxane-contaminated-water-with-slow-release-persulfate-and-zerovalent-iron
#6
Ann Kambhu, Megan Gren, Wei Tang, Steve Comfort, Clifford E Harris
1,4-dioxane is an emerging contaminant that was used as a corrosion inhibitor with chlorinated solvents. Metal-activated persulfate can degrade dioxane but reaction kinetics have typically been characterized by a rapid decrease during the first 30 min followed by either a slower decrease or no further change (i.e., plateau). Our objective was to identify the factors responsible for this plateau and then determine if slow-release formulations of sodium persulfate and Fe(0) could provide a more sustainable degradation treatment...
February 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28222303/organic-dye-removal-from-aqueous-solutions-by-hierarchical-calcined-ni-fe-layered-double-hydroxide-isotherm-kinetic-and-mechanism-studies
#7
Chunsheng Lei, Meng Pi, Panyong Kuang, Yingqing Guo, Fenge Zhang
Hierarchically porous nickel-iron-layered double hydroxide (NiFe-LDH) with a Ni(2+)/Fe(3+) molar ratio of 3 was successfully synthesised through a simple hydrothermal route. After calcination at 400°C, NiFe-LDH transformed into nickel-iron-layered double oxides (NiFe-LDO). The as-prepared samples were characterised through X-ray powder diffraction, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and nitrogen adsorption...
February 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28222266/kinetic-and-diffusion-driven-instabilities-in-the-bromate-sulfite-ferrocyanide-system
#8
István Molnár, Istvan Szalai
The spatiotemporal dynamics of the Bromate-Sulfite-Ferrocyanide (BSF) reaction-diffusion system in a open one-side-fed reactor (OSFR) is investigated by numerical simulations. The results of the simulations are compared with experiments performed in an annular shape OSFR. Both kinetic and diffusion driven instabilities are identified in the model. There are two hydrogen ion consuming pathways in the mechanism, the partial oxidation of sulfite to dithionate and the oxidation of ferrocyanide by bromate ions. The dynamical effects of them are similar as they support the same negative feedback loop via sulfite ion...
February 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28222257/an-iron-ii-ylide-complex-as-a-masked-open-shell-iron-alkylidene-species-in-its-alkylidene-transfer-reactions-with-alkenes
#9
Jian Liu, Lianrui Hu, Lei Wang, Hui Chen, Liang Deng
Transition-metal alkylidenes are important reactive organometallic intermediates, and our current knowledge on them has been mainly restricted to those with closed-shell electronic configurations. In this study, we present the exploration on open-shell iron alkylidenes with a weak-field tripodal amido-phosphine-amido ligand. We found that a high-spin (amido-phosphine-amido)iron(II) complex can react with (p-tolyl)2CN2 to afford a high-spin (amido-ylide-amido)iron(II) complex, 2, which could transfer its alkylidene moiety to a variety of alkenes, either the electron-rich or electron-deficient ones, to form cyclopropane derivatives...
February 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28222253/flow-cytometry-based-rapid-duplexed-immunoassay-for-fusarium-mycotoxins
#10
Árpád Czéh, Miklós Mézes, Francis Mandy, Zsuzsanna Szőke, György Nagyéri, Noémi Laufer, Balázs Kőszegi, Tamás Koczka, Sándor Kunsági-Máté, György Lustyik
At small food processing facilities, the most frequently used test to determine if grain-derived mycotoxin concentrations are compliant with legal limits is the enzyme-linked immunosorbent assay (ELISA). Each kit is designed to detect one of the six dangerous mycotoxins. With the increasing occurrence of coinfection of grain with multiple-mycotoxins in the field and/or during storage, ELISA is no longer a cost effective best assay option. With ELISA, each species of mycotoxin requires different sample preparation/extraction and a 45 min incubation...
February 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28222243/studies-on-the-binding-of-modest-modulators-of-the-human-enzyme-sirtuin-6-using-std-nmr
#11
Beatriz E Bolívar, John T Welch
Pyrazinamide (PZA), an essential constituent of short course tuberculosis chemotherapy, binds weakly but selectively to Sirtuin 6 (SIRT6). Despite structural similarities between nicotinamide (NAM), PZA, and pyrazinoic acid (POA), these inhibitors modulate SIRT6 via different mechanisms and binding sites, as suggested by Saturation Transfer Difference (STD) Nuclear Magnetic Resonance (NMR). Available experimental evidence, such as that derived from crystal structures and kinetic experiments, is of only limited utility in the elucidation of the mechanistic details of sirtuin inhibition by NAM or other inhibitors...
February 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28222073/a-phase-i-study-of-intravenous-and-oral-rucaparib-in-combination-with-chemotherapy-in-patients-with-advanced-solid-tumours
#12
Richard H Wilson, Tr Jeffry Evans, Mark R Middleton, L Rhoda Molife, James Spicer, Veronique Dieras, Patricia Roxburgh, Heidi Giordano, Sarah Jaw-Tsai, Sandra Goble, Ruth Plummer
BACKGROUND: This study evaluated safety, pharmacokinetics, and clinical activity of intravenous and oral rucaparib, a poly(ADP-ribose) polymerase inhibitor, combined with chemotherapy in patients with advanced solid tumours. METHODS: Initially, patients received escalating doses of intravenous rucaparib combined with carboplatin, carboplatin/paclitaxel, cisplatin/pemetrexed, or epirubicin/cyclophosphamide. Subsequently, the study was amended to focus on oral rucaparib (once daily, days 1-14) combined with carboplatin (day 1) in 21-day cycles...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28222028/expression-purification-and-characterization-of-human-cytosolic-sulfotransferase-sult-1c4
#13
Amber L Guidry, Zachary E Tibbs, Melissa Runge-Morris, Charles N Falany
Human cytosolic sulfotransferase 1C4 (hSULT1C4) is a dimeric Phase II drug-metabolizing enzyme primarily expressed in the developing fetus. SULTs facilitate the transfer of a hydrophilic sulfonate moiety from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) onto an acceptor substrate altering the substrate's biological activity and increasing the compound's water solubility. While several of the hSULTs' endogenous and xenobiotic substrates have been identified, the physiological function of hSULT1C4 remains unknown...
February 21, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28221983/biogenic-amines-and-predictive-models-of-quality-of-rainbow-trout-oncorhynchus-mykiss-fillets-during-storage
#14
Qingzheng Li, Jian Lv, Longteng Zhang, Zehong Dong, Ligeng Feng, Yongkang Luo
To estimate biogenic amines and changes in quality of rainbow trout ( Oncorhynchus mykiss ) fillets at different temperatures, we determined the sensory attributes, total volatile basic nitrogen (TVB-N), total viable counts (TVC), and biogenic amines (BAs) of samples that were untreated (CK) or dry cured with 1.8% salt (T). There was no significant difference between CK and T samples in terms of TVB-N, TVC, and BAs. TVB-N and TVC increased significantly (P < 0.05) with storage time at 3, 9, and 15°C. Putrescine (PUT) and cadaverine (CAD) increased significantly (P < 0...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221933/thermal-inactivation-kinetics-of-sporolactobacillus-nakayamae-spores-a-spoilage-bacterium-isolated-from-a-model-mashed-potato-scallion-mixture
#15
Hayriye Bozkurt, Jairus R D David, Ryan J Talley, D Scott Lineback, P Michael Davidson
Sporolactobacillus species have been occasionally isolated from spoiled foods and environmental sources. Thus, food processors should be aware of their potential presence and characteristics. In this study, the heat resistance and influence of the growth and recovery media on apparent heat resistance of Sporolactobacillus nakayamae spores were studied and described mathematically. For each medium, survivor curves and thermal death curves were generated for different treatment times (0 to 25 min) at different temperatures (70, 75, and 80°C) and Weibull and first-order models were compared...
September 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221914/effects-of-inoculation-procedures-on-variability-and-repeatability-of-salmonella-thermal-resistance-in-wheat-flour
#16
Ian M Hildebrandt, Bradley P Marks, Elliot T Ryser, Rossana Villa-Rojas, Juming Tang, Francisco J Garces-Vega, Sarah E Buchholz
Limited prior research has shown that inoculation methods affect thermal resistance of Salmonella in low-moisture foods; however, these effects and their repeatability have not been systematically quantified. Consequently, method variability across studies limits utility of individual data sets and cross-study comparisons. Therefore, the objective was to evaluate the effects of inoculation methodologies on stability and thermal resistance of Salmonella in a low-moisture food (wheat flour), and the repeatability of those results, based on data generated by two independent laboratories...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221910/influence-of-thawing-methods-and-storage-temperatures-on-bacterial-diversity-growth-kinetics-and-biogenic-amine-development-in-atlantic-mackerel
#17
S Onyango, H Palmadottir, T Tómason, V T Marteinsson, P M K Njage, E Reynisson
Limited knowledge is currently available on the influence of fish thawing and subsequent storage conditions on bacterial growth kinetics, succession, and diversity alongside the production of biogenic amines. This study aimed to address these factors during the thawing and subsequent storage of mackerel. Thawing was either done fast in 18°C water for 2 h or slowly at 30°C overnight. Subsequent storage was at 30°C (ambient) for 36 h and 2 to 5°C (refrigerated) for 12 days. The cultivation methods used were total viable counts, hydrogen sulfide-producing bacteria, and Pseudomonas ...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221892/effects-of-ohmic-heating-including-electric-field-intensity-and-frequency-on-thermal-inactivation-of-bacillus-subtilis-spores
#18
Suguru Murashita, Shuso Kawamura, Shigenobu Koseki
Methods for microbial inactivation are important in the food industry; however, conventional external heating (CH) reduces food quality. Accordingly, the nonthermal effects of ohmic heating (OH) on Bacillus subtilis spores in a sodium chloride aqueous solution at 101°C (i.e., the boiling point), as well as the effects of electric field intensity and frequency during OH, were investigated. Survival kinetics were compared between OH and external CH. The inactivation effect on B. subtilis was greater for all electric field conditions (5, 10, and 20 V/cm) than for CH...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221855/survival-kinetics-of-salmonella-enterica-and-enterohemorrhagic-escherichia-coli-on-a-plastic-surface-at-low-relative-humidity-and-on-low-water-activity-foods
#19
Hidekazu Hokunan, Kento Koyama, Mayumi Hasegawa, Shuso Kawamura, Shigenobu Koseki
We investigated the survival kinetics of Salmonella enterica and enterohemorrhagic Escherichia coli under various water activity (aw) conditions to elucidate the net effect of aw on pathogen survival kinetics and to pursue the development of a predictive model of pathogen survival as a function of aw. Four serotypes of S. enterica (Stanley, Typhimurium, Chester, and Oranienburg) and three serotypes of enterohemorrhagic E. coli ( E. coli O26, E. coli O111, and E. coli O157:H7) were examined. These bacterial strains were inoculated on a plastic plate surface at a constant relative humidity (RH) (22, 43, 58, 68, or 93% RH, corresponding to the aw) or on a surface of almond kernels (aw 0...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221847/thermal-and-starvation-stress-response-of-escherichia-coli-o157-h7-isolates-selected-from-agricultural-environments
#20
Achyut Adhikari, Andy Bary, Craig Cogger, Caleb James, Gülhan Ünlü, Karen Killinger
Pathogens exposed to agricultural production environments are subject to multiple stresses that may alter their survival under subsequent stress conditions. The objective of this study was to examine heat and starvation stress response of Escherichia coli O157:H7 strains isolated from agricultural matrices. Seven E. coli O157:H7 isolates from different agricultural matrices-soil, compost, irrigation water, and sheep manure-were selected, and two ATCC strains were used as controls. The E. coli O157:H7 isolates were exposed to heat stress (56°C in 0...
October 2016: Journal of Food Protection
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