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https://www.readbyqxmd.com/read/27889508/physiological-responses-and-changes-in-gene-expression-in-the-large-yellow-croaker-larimichthys-crocea-following-exposure-to-hypoxia
#1
Qian-Feng Wang, Wei-Liang Shen, Cong-Cong Hou, Cheng Liu, Xiong-Fei Wu, Jun-Quan Zhu
Organisms at all levels of evolutionary complexity react to hypoxic stress. To clarify the effects of acute hypoxia on physiological and biochemical responses of Larimichthys crocea, we measured the activity levels of the antioxidant enzymes superoxide dismutase and catalase, hemoglobin concentration, functional indices of the liver (aspartate transaminase, alanine transaminase), heart (phosphocreatine kinase), and immune system (alkaline phosphatase), as well as mRNA expression levels of the immunity-related genes Hsp70 and HIF-1α at different time points of hypoxic...
November 24, 2016: Chemosphere
https://www.readbyqxmd.com/read/27871865/iterative-reconstruction-of-radially-sampled-31-p-bssfp-data-using-prior-information-from-1-h-mri
#2
Kristian Rink, Nadia Benkhedah, Moritz C Berger, Christine Gnahm, Nicolas G R Behl, Jonathan M Lommen, Vanessa Stahl, Peter Bachert, Mark E Ladd, Armin M Nagel
The purpose of this study is to improve direct phosphorus ((31)P) MR imaging. Therefore, 3D density-adapted radially-sampled balanced steady-state free precession (bSSFP) sequences were developed and an iterative approach exploiting additional anatomical information from hydrogen ((1)H) data was evaluated. Three healthy volunteers were examined at B0=7T in order to obtain the spatial distribution of the phosphocreatine (PCr) intensities in the human calf muscle with a nominal isotropic resolution of 10mm in an acquisition time of 10min...
November 19, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27870506/differential-neurometabolite-alterations-in-brains-of-medication-free-individuals-with-bipolar-disorder-and-those-with-unipolar-depression-a-two-dimensional-proton-magnetic-resonance-spectroscopy-study
#3
Hui Li, Haiyun Xu, Yinnan Zhang, Jitian Guan, Jie Zhang, Chongtao Xu, Zhiwei Shen, Bo Xiao, Chunlian Liang, Kaiyuan Chen, Jinling Zhang, Renhua Wu
OBJECTIVES: Bipolar disorder (BD) is a mental disorder characterized by periods of elevated mood and depression. Many individuals with BD are initially misdiagnosed and treated for unipolar depression (UD). In this study, we report direct comparisons between medication-free individuals with BD and those with UD in terms of the neurometabolites in the anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), parietal cortex (PC), and posterior cingulate cortex (PCC) of the brain...
November 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27862510/dynamic-31-p-mrsi-using-spiral-spectroscopic-imaging-can-map-mitochondrial-capacity-in-muscles-of-the-human-calf-during-plantar-flexion-exercise-at-7%C3%A2-t
#4
Ladislav Valkovič, Marek Chmelík, Martin Meyerspeer, Borjan Gagoski, Christopher T Rodgers, Martin Krššák, Ovidiu C Andronesi, Siegfried Trattnig, Wolfgang Bogner
Phosphorus MRSI ((31) P-MRSI) using a spiral-trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle. The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunteers, who performed a plantar flexion exercise inside a whole-body 7 T MR scanner using an MR-compatible ergometer and a surface coil. In five volunteers the knee was flexed (~60°) to shift the major workload from the gastrocnemii to the soleus muscle...
December 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27859827/elevated-phosphodiester-and-t2-levels-can-be-measured-in-the-absence-of-fat-infiltration-in-duchenne-muscular-dystrophy-patients
#5
M T Hooijmans, E H Niks, J Burakiewicz, J J G M Verschuuren, A G Webb, H E Kan
Quantitative MRI and MRS are increasingly important as non-invasive outcome measures in therapy development for Duchenne muscular dystrophy (DMD). Many studies have focussed on individual measures such as fat fraction and metabolite levels in relation to age and functionality, but much less attention has been given to how these indices relate to each other. Here, we assessed spatially resolved metabolic changes in leg muscles of DMD patients, and classified muscles according to the degree of fat replacement compared with healthy controls...
November 17, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27847932/neurochemical-alterations-in-anterior-cingulate-cortex-in-bipolar-disorder-a-proton-magnetic-resonance-spectroscopy-study-1h-mrs
#6
Beata Galińska-Skok, Beata Konarzewska, Bożena Kubas, Eugeniusz Tarasów, Agata Szulc
OBJECTIVES: The aim of this study was to determine neurochemical alterations in bipolar disorder using proton magnetic resonance spectroscopy (1H-MRS). METHODS: We investigated a group of 27 patients diagnosed with bipolar disorder (with manic and mixed episodes, depression and after remission of symptoms) and 10 healthy subjects. MR imaging and 1H-MRS were performed on a 1.5 T scanner. Voxels of 8 cm3 were positioned in the anterior cingulate, left frontal lobe and left temporal lobe...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27847299/an-mrspec-database-query-and-visualization-engine-with-applications-as-a-clinical-diagnostic-and-research-tool
#7
Filip Miscevic, Justin Foong, Benjamin Schmitt, Susan Blaser, Michael Brudno, Andreas Schulze
PURPOSE: Proton magnetic resonance spectroscopy (MRspec), one of the very few techniques for in vivo assessment of neuro-metabolic profiles, is often complicated by lack of standard population norms and paucity of computational tools. METHODS: 7035 scans and clinical information from 4430 pediatric patients were collected from 2008 to 2014. Scans were conducted using a 1.5T (n=3664) or 3T scanner (n=3371), and with either a long (144ms, n=5559) or short echo time (35ms, n=1476)...
November 9, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27816519/cognitive-decline-in-type-2-diabetic-db-db-mice-may-be-associated-with-brain-region-specific-metabolic-disorders
#8
Hong Zheng, Yongquan Zheng, Liangcai Zhao, Minjiang Chen, Guanghui Bai, Yongsheng Hu, Wenyi Hu, Zhihan Yan, Hongchang Gao
Type 2 diabetes has been associated with cognitive decline, but its metabolic mechanism remains unclear. In the present study, we attempted to investigate brain region-specific metabolic changes in db/db mice with cognitive decline and explore the potential metabolic mechanism linking type 2 diabetes and cognitive decline. We analyzed the metabolic changes in seven brain regions of two types of mice (wild-type mice and db/db mice with cognitive decline) using a (1)H NMR-based metabolomic approach. Then, a mixed-model analysis was used to evaluate the effects of mice type, brain region, and their interaction on metabolic changes...
November 3, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27781150/brain-metabolite-levels-and-language-abilities-in-preschool-children
#9
Catherine Lebel, Frank P MacMaster, Deborah Dewey
INTRODUCTION: Language acquisition occurs rapidly during early childhood and lays the foundation for future reading success. However, little is known about the brain-language relationships in young children. The goal of this study was to investigate relationships between brain metabolites and prereading language abilities in healthy preschool-aged children. METHODS: Participants were 67 healthy children aged 3.0-5.4 years scanned on a 3T GE MR750w MRI scanner using short echo proton spectroscopy with a voxel placed in the anterior cingulate gyrus (n = 56) and/or near the left angular gyrus (n = 45)...
October 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27779341/study-of-neurometabolic-and-behavioral-alterations-in-rodent-model-of-mild-traumatic-brain-injury-a-pilot-study
#10
Kavita Singh, Richa Trivedi, Seenu Haridas, Kailash Manda, Subash Khushu
Mild traumatic brain injury (mTBI) is the most common form of TBI (70-90%) with consequences of anxiety-like behavioral alterations in approximately 23% of mTBI cases. This study aimed to assess whether mTBI-induced anxiety-like behavior is a consequence of neurometabolic alterations. mTBI was induced using a weight drop model to simulate mild human brain injury in rodents. Based on injury induction and dosage of anesthesia, four animal groups were included in this study: (i) injury with anesthesia (IA); (ii) sham1 (injury only, IO); (iii) sham2 (only anesthesia, OA); and (iv) control rats...
October 25, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27747196/shiga-toxin-mediated-neurologic-changes-in-murine-model-of-disease
#11
Suman Pradhan, Christine Pellino, Kayleigh MacMaster, Dennis Coyle, Alison A Weiss
Seizures and neurologic involvement have been reported in patients infected with Shiga toxin (Stx) producing E. coli, and hemolytic uremic syndrome (HUS) with neurologic involvement is associated with more severe outcome. We investigated the extent of renal and neurologic damage in mice following injection of the highly potent form of Stx, Stx2a, and less potent Stx1. As observed in previous studies, Stx2a brought about moderate to acute tubular necrosis of proximal and distal tubules in the kidneys. Brain sections stained with hematoxylin and eosin (H&E) appeared normal, although some red blood cell congestion was observed...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27743811/could-the-pulmonary-v%C3%AB-o2-off-transient-response-to-maximal-short-term-exercise-be-better-characterized-by-a-triexponential-decay
#12
Rogério Santos de Oliveira Cruz, Tiago Turnes, Rafael Alves de Aguiar, Fabrizio Caputo
The off-transient pulmonary oxygen uptake (V˙O2) response to a single bout of intense, exhaustive exercise has been characterized over the years by a second-order exponential model. In this paper, we report the superiority of a third-order exponential decay in describing the V˙O2 off-kinetics after a maximal cycling exercise lasting 60-s. Our findings are in accordance with a biphasic pattern of phosphocreatine resynthesis when muscle pH is affected.
January 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27742491/altered-breast-milk-components-in-preeclampsia-an-in-vitro-proton-nmr-spectroscopy-study
#13
Kamini Dangat, Deepti Upadhyay, Anitha Kilari, Uma Sharma, Nisha Kemse, Savita Mehendale, Sanjay Lalwani, Girija Wagh, Sadhana Joshi, Naranamangalam R Jagannathan
OBJECTIVE: To investigate the metabolic profile of milk on day 3 and at the 6th month of lactation in mothers with preeclampsia (PE) and normotensive mothers. STUDY DESIGN: Women with PE (n=29) and control women (n=31) were recruited for this study. Milk was collected on day 3 and at the 6th month of lactation. Proton NMR spectroscopy was used to identify 25 milk metabolites (alpha-lactose, beta-lactose, oligosaccharides, myo-inositol, alanine, glutamate, glutamine, glycine, histidine, isoleucine, leucine, lysine, phenylalanine, tyrosine, valine, acetone, citrate, creatine, phosphocreatine, acetate, choline, lactate, lipid, phosphocholine and glycerophosphocholine)...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27737951/insulin-resistance-is-associated-with-reduced-mitochondrial-oxidative-capacity-measured-by-31p-magnetic-resonance-spectroscopy-in-non-diabetic-participants-from-the-baltimore-longitudinal-study-of-aging
#14
Elisa Fabbri, Chee W Chia, Richard G Spencer, Kenneth W Fishbein, David A Reiter, Donnie Cameron, Ariel C Zane, Zenobia A Moore, Marta Gonzalez-Freire, Marco Zoli, Stephanie A Studenski, Rita R Kalyani, Josephine M Egan, Luigi Ferrucci
Whether individuals with insulin resistance but without criteria for diabetes exhibit reduced mitochondrial oxidative capacity is unclear; addressing this question could guide research for new therapeutics. We investigated 248 non-diabetic participants from the Baltimore Longitudinal Study of Aging (BLSA) to determine whether impaired mitochondrial capacity is associated with prediabetes, insulin resistance, duration and severity of hyperglycemia exposure. Mitochondrial capacity was assessed as post-exercise phosphocreatine recovery time constant (τPCr) by (31)P-magnetic resonance spectroscopy, with higher τPCr reflecting reduced capacity...
October 13, 2016: Diabetes
https://www.readbyqxmd.com/read/27695638/frontal-metabolite-concentration-deficits-in-opiate-dependence-relate-to-substance-use-cognition-and-self-regulation
#15
Donna E Murray, Timothy C Durazzo, Thomas P Schmidt, Christoph Abé, Joseph Guydish, Dieter J Meyerhoff
OBJECTIVE: Proton magnetic resonance spectroscopy (1H MRS) in opiate dependence showed abnormalities in neuronal viability and glutamate concentration in the anterior cingulate cortex (ACC). Metabolite levels in dorsolateral prefrontal cortex (DLPFC) or orbitofrontal cortex (OFC) and their neuropsychological correlates have not been investigated in opiate dependence. METHODS: Single-volume proton MRS at 4 Tesla and neuropsychological testing were conducted in 21 opiate-dependent individuals (OD) on buprenorphine maintenance therapy...
August 2016: Journal of Addiction Research & Therapy
https://www.readbyqxmd.com/read/27680221/a-case-of-cerebrotendinous-xanthomatosis-mimicking-the-clinical-phenotype-of-mitochondrial-disease-with-a-novel-frame-shift-mutation-c-43_44-delgg-in-cyp27a1-gene-exon-1
#16
Junpei Koge, Shintaro Hayashi, Hiroo Yamaguchi, Takahisa Tateishi, Hiroyuki Murai, Jun-Ichi Kira
A 37-old-male with a history of early childhood mental retardation was admitted to our hospital. He experienced recurrent syncopes at 23 years old, and at age 35 gait disturbance and hearing impairment developed gradually and worsened over time. His grandparents were in a consanguineous marriage. He was of short stature and absent of tendon xanthomas. Neurological examinations revealed scanning speech, dysphagia, right sensorineural hearing loss, spasticity in both upper and lower extremities, and spastic gait...
September 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27672632/comparison-of-brain-development-in-sow-reared-and-artificially-reared-piglets
#17
Reeba M Jacob, Austin T Mudd, Lindsey S Alexander, Chron-Si Lai, Ryan N Dilger
INTRODUCTION: Provision of adequate nutrients is critical for proper growth and development of the neonate, yet the impact of breastfeeding versus formula feeding on neural maturation has to be fully determined. Using the piglet as a model for the human infant, our objective was to compare neurodevelopment of piglets that were either sow-reared (SR) or artificially reared (AR) in an artificial setting. METHODS: Over a 25-day feeding study, piglets (1.5 ± 0...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27672179/ereply-phosphocreatine-in-cardiovascular-disease-how-can-we-relate-the-evidence-to-clinical-practice
#18
Evgeny Fominskiy, Giovanni Landoni
No abstract text is available yet for this article.
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27672178/ecomment-phosphocreatine-in-cardiovascular-disease-how-can-we-relate-the-evidence-to-clinical-practice
#19
Oliver I Brown
No abstract text is available yet for this article.
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27663970/magnetic-resonance-spectroscopic-analysis-of-neurometabolite-changes-in-the-developing-rat-brain-at-7-tesla
#20
Jaivijay Ramu, Tetyana Konak, Serguei Liachenko
We utilized proton magnetic resonance spectroscopy to evaluate the metabolic profile of the hippocampus and anterior cingulate cortex of the developing rat brain from postnatal days 14 to 70. Measured metabolite concentrations were modelled using linear, exponential, or logarithmic functions and the time point at which the data reached plateau (i.e. when the portion of the data could be fit to horizontal line) was estimated and was interpreted as the time when the brain has reached maturity with respect to that metabolite...
September 20, 2016: Brain Research
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