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https://www.readbyqxmd.com/read/29910741/physiology-and-pathophysiology-in-ultra-marathon-running
#1
REVIEW
Beat Knechtle, Pantelis T Nikolaidis
In this overview, we summarize the findings of the literature with regards to physiology and pathophysiology of ultra-marathon running. The number of ultra-marathon races and the number of official finishers considerably increased in the last decades especially due to the increased number of female and age-group runners. A typical ultra-marathoner is male, married, well-educated, and ~45 years old. Female ultra-marathoners account for ~20% of the total number of finishers. Ultra-marathoners are older and have a larger weekly training volume, but run more slowly during training compared to marathoners...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29910344/exertional-rhabdomyolysis-after-an-extreme-conditioning-competition-a-case-report
#2
Ramires Alsamir Tibana, Nuno Manuel Frade de Sousa, Gabriel Veloso Cunha, Jonato Prestes, James W Navalta, Fabricio Azevedo Voltarelli
This case report describes an instance of exercise-induced rhabdomyolysis caused by an extreme conditioning program (ECP) competition. A 35-year-old female presented with abdominal pain and soreness, which began one day after she completed two days of ECPcompetition composed of five workouts. Three days after competition, creatine kinase (CK) was 77,590 U/L accompanied by myalgia and abnormal liver function tests, while renal function was normal and this resulted in a diagnosis of rhabdomyolysis. A follow-up examination revealed that her serum level of CK was still elevated to 3034 U/L on day 10 and 1257 U/L on day 25 following the ECP competition...
April 26, 2018: Sports (Basel)
https://www.readbyqxmd.com/read/29910216/protective-effects-of-shenfu-injection-against-myocardial-ischemia-reperfusion-injury-via-activation-of-enos-in-rats
#3
Wang Yan-Yan, Li Yan-Yan, Li Lin, Yang Dong-Li, Zhou Kun, Li Yu-Hong
The aim of the present study was to investigate the protective effects of Shenfu injection (SFI) against myocardial ischemia/reperfusion injury (MIRI) in model rats and to explore its mechanism of action. Sprague-Dawley (SD) rats were pretreated with SFI and L-NAME via tail vein injection and then rats were subjected to ischemia by occlusion of the left anterior descending coronary artery for 30min followed by reperfusion for 120min. Left ventricular function was evaluated by echocardiography. Hemodynamic was measured by the Millar pressure - volume system; serum creatine kinase (CK), lactate dehydrogenase (LDH) and serum troponin (TNNI3) levels were determined...
June 16, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29910097/a-novel-compound-heterozygous-mutation-in-the-pomk-gene-causing-limb-girdle-muscular-dystrophy-dystroglycanopathy-in-a-sib-pair
#4
Sonja Strang-Karlsson, Katherine Johnson, Ana Töpf, Liwen Xu, Monkol Lek, Daniel G MacArthur, Olivera Casar-Borota, Maria Williams, Volker Straub, Carina Wallgren-Pettersson
We describe two Finnish siblings in whom an incidentally detected elevated creatine kinase activity eventually led to a diagnosis of limb-girdle muscular dystrophy-dystroglycanopathy (Type C12; MDDGC12). When diagnosed at age 10 and 13 years, they were mildly affected with a slow or non-progressive disease course. The main symptoms comprised infrequent hip cramps triggered by flexion, neck cramps triggered by yawning, transient growing pains, calf hypertrophy and mild proximal muscle weakness. Their cognitive and motor developments were unremarkable and they were physically active...
May 16, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29908956/complement-activation-in-acute-myocardial-infarction-an-early-marker-of-inflammation-and-tissue-injury
#5
Lorena Bavia, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Miguel Ibraim Abboud Hanna Sobrinho, Renato Mitsunori Nisihara, Iara Jose de Messias-Reason
BACKGROUND: Acute myocardial infarction (AMI) is a potentially fatal condition, being a major cause of death worldwide. Ischemia suffered during AMI causes tissue damage, leading to an inflammatory process. Moreover, myocardial injury can generate damage-associated molecular patterns that activate pattern recognition molecules including some complement proteins. METHODS: Here we investigated products of complement activation, C3d and soluble C5b9 (sC5b9), as potential biomarkers for myocardial injury and inflammation, as well as serum cytokines (IL-6 and TNF-alpha), alpha-1-acid glycoprotein (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital)...
June 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29904441/ischemic-modified-albumin-predicts-critical-coronary-artery-disease-in-unstable-angina-pectoris-and-non-st-elevation-myocardial-infarction
#6
Abdullah Orhan Demirtas, Turgut Karabag, Derya Demirtas
Background: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. Methods: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29903623/immune-checkpoint-mediated-myositis-and-myasthenia-gravis-a-case-report-and-review-of-evaluation-and-management
#7
Kylie H Kang, William Grubb, Komal Sawlani, Michael K Gibson, Christopher J Hoimes, Lisa R Rogers, Pierre Lavertu, Min Yao
BACKGROUND: We present a case of myositis and possible overlapping neuromuscular junction disorder following treatment with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). METHODS: We report a 75-year-old man with recurrent stage IVA, T1N2cM0 oral cavity HNSCC treated with weight-dosed nivolumab who presented three weeks later with severe fatigue, generalized weakness, and bilateral ptosis. Evaluation demonstrated elevated creatine kinase and myopathic motor units on electromyography, supporting a diagnosis of an underlying muscle disease...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29902618/polycyclic-aromatic-hydrocarbon-exposure-impairs-pre-migratory-fuelling-in-captively-dosed-sanderling-calidris-alba
#8
Kristin Bianchini, Christy A Morrissey
Efficient fuelling is essential for migratory birds because fuel loads and fuelling rates affect individual fitness and survival during migration. Many migrant shorebirds are exposed to oil pollution and its toxic constituents, polycyclic aromatic hydrocarbons (PAHs), at migratory staging sites, which has the potential to interfere with avian refuelling physiology. In this study, we orally dosed shorebirds with environmentally-relevant PAH mixtures to simulate dietary exposure during staging. Forty-nine wild-caught Sanderling (Calidris alba) were exposed to 0 (control), 12...
June 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29901562/massive-creatine-kinase-elevation-in-2-patients-during-short-term-and-low-dose-antipsychotic-monotherapy-with-quetiapine
#9
Patrick Bach, Anne Koopmann, Derik Hermann, Falk Kiefer, Jan Malte Bumb
No abstract text is available yet for this article.
June 12, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29901189/protective-effects-of-scoparone-against-ischemia%C3%A2-reperfusion%C3%A2-induced-myocardial-injury
#10
Chunfu Wan, Yueyue Wei, Jianguo Ma, Xiaoyong Geng
The present study aimed to investigate the protective effects and molecular mechanisms of scoparone on ischemia‑reperfusion (I/R) injury in primary cultured cardiac myocytes and rats. An in vivo rat model of I/R injury and an in vitro primary cultured cardiac myocyte model of oxygen‑glucose deprivation/reoxygenation were used to investigate the protective effects of scoparone. Cell viability, lactate dehydrogenase (LDH) release, superoxide dismutase (SOD), creatine kinase (CK) and malondialdehyde (MDA) levels, and reactive oxygen species (ROS) production were subsequently measured...
June 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900763/hematology-and-serum-biochemistry-values-of-the-red-panda-subspecies-ailurus-fulgens-styani
#11
Caitlin Burrell, Li Luo, Marieke Kester Jones, Andrea Lee, Elizabeth Freeman, Copper Aitken-Palmer
  Health evaluations were conducted on individuals ( n = 62, age < 1 to 11 yr) from a captive red panda ( Ailurus fulgens styani) population at the Chengdu Research Base for Giant Panda Breeding in Sichuan Province, People's Republic of China. Individuals were anesthetized using combinations of ketamine, dexmedetomidine, diazepam, isoflurane, and tiletamine/zolazepam. Whereas physical exams revealed no abnormalities for 40% of red pandas, 24% had dental abnormalities and 18% had orthopedic abnormalities...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29898248/serum-myoglobin-creatine-kinase-and-cell-free-dna-in-endurance-sled-dogs-and-sled-dogs-with-clinical-rhabdomyolysis
#12
Veronica C Devall, Robert Goggs, Christina Hansen, Christopher W Frye, Jo-Annie Letendre, Joseph J Wakshlag
OBJECTIVE: To evaluate whether cell-free DNA (cfDNA) concentrations are increased in dogs with exertional rhabdomyolysis and whether concentrations are correlated with serum myoglobin concentration and creatine kinase activity. DESIGN: Observational cohort study. SETTING: Yukon Quest 1,000-mile International Sled Dog Race 2015. ANIMALS: Twelve normal competitive sled dogs; 5 dogs with rhabdomyolysis. INTERVENTIONS: None...
June 13, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29898093/x-linked-spinal-and-bulbar-muscular-atrophy-kennedy-s-disease-the-first-case-described-in-the-brazilian-amazon
#13
Camila Nascimento Alves, Tiago Kiyoshi Kitabayashi Braga, Danusa Neves Somensi, Bruno Sérgio Vilhena do Nascimento, José Antônio Santos de Lima, Satomi Fujihara
The X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is a rare X-linked, recessive, lower motor neuron disease, characterized by weakness, atrophy, and fasciculations of the appendicular and bulbar muscle. The disease is caused by an expansion of the CAG repetition in the androgen receptor gene. Patients with Kennedy's disease have more than 39 CAG repetitions. We report a case of 57-year-old man, resident of Monte Dourado (PA, Brazil) who complained of brachiocrural paresis evolving for 3 years along with fasciculations and tremors of extremities...
June 7, 2018: Einstein
https://www.readbyqxmd.com/read/29898033/interleukin-6-contributes-to-myocardial-damage-in-pregnant-rats-with-reduced-uterine-perfusion-pressure
#14
Lan Ding, Chuanming Bai, Ying Liu
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29895548/primary-carnitine-deficiency-in-a-57-year-old-patient-with-recurrent-exertional-rhabdomyolysis
#15
Andoni Echaniz-Laguna, Valérie Biancalana, Pauline Gaignard, Jean-Baptiste Chanson
Rhabdomyolysis is an emergency requiring rapid diagnosis and suitable aetiological treatment. We describe the case of a 57-year-old man with recurrent exertional rhabdomyolysis who was diagnosed with systemic primary carnitine deficiency (SPCD). Clinical examination was normal, creatine kinase levels were elevated, plasma free carnitine concentration was mildly decreased, muscle biopsy demonstrated lipid accumulation, carnitine uptake in cultured fibroblasts was decreased and genetic analysis identified a homozygous pathologic c...
June 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29895236/effect-of-compression-garments-on-the-development-of-delayed-onset-muscle-soreness-a-multimodal-approach-using-contrast-enhanced-ultrasound-and-acoustic-radiation-force-impulse-elastography
#16
Rafael Heiss, Marion Kellermann, Bernd Swoboda, Casper Grim, Matthias S May, Wolfgang Wuest, Michael Uder, Armin M Nagel, Thilo Hotfiel
Study Design Controlled laboratory study with repeated measures. Background Delayed-onset muscle soreness (DOMS) is one of the most common reasons for impaired muscle performance in sports. However, little consensus exists regarding which treatments may be most effective and the underlying mechanisms are poorly understood. Objectives To investigate the influence of compression garments on the development of DOMS, focusing on changes in muscle perfusion and muscle stiffness. Methods Muscle perfusion and stiffness, calf circumference, muscle soreness, passive ankle dorsiflexion, and creatine kinase levels were assessed on participants before (baseline) a DOMS-inducing eccentric calf exercise intervention and 60 h later (follow-up)...
June 12, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29893709/svr-24-achievement-two-weeks-after-a-tripled-dose-of-daclatasvir-in-an-hcv-genotype-3-patient
#17
Sara Lo Menzo, Enrico Biagi, Mariachiara Di Nuzzo, Anastasio Grilli, Carlo Contini
Directly-acting antivirals (DAA) have changed the chronic hepatitis C virus (HCV) infection therapeutic scenario allowing virus eradication in more than 95% of patients, independently from the genotype, with 12 to 24-week treatment regimens. We describe a 51-year-old Pakistani man with a chronic HCV-genotype 3 (GT3a) infection with moderate liver fibrosis, who achieved sustained virological response (SVR) 24 after a tripled dose of Daclatasvir (DCV) taken erroneously associated to Sofosbuvir (SOF). The patient had a concomitant intestinal TB infection whose treatment had been delayed in order to firstly eradicate HCV to reduce the liver toxicity of anti-mycobacterial drugs...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29891833/x-linked-dilated-cardiomyopathy-presenting-as-acute-rhabdomyolysis-and-presumed-epstein-barr-virus-induced-viral-myocarditis-a-case-report
#18
Jacques A J Malherbe, Sue Davel
BACKGROUND Rhabdomyolysis and primary dilated cardiomyopathies without skeletal muscle weakness are rare features of X-linked dystrophinopathies. We report a rare case of an X-linked dilated cardiomyopathy (XLDCM) presenting with acute rhabdomyolysis and myocarditis. We illustrate the confounding diagnostic influence of a reactivated, persistent EBV myocarditis as the presumed cause for this patient's XLDCM. CASE REPORT A 23-year-old Australian man presented with acute rhabdomyolysis and elevated creatine kinase (CK) levels...
June 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29891235/prodromal-symptoms-predict-myocardial-involvement-in-patients-with-acute-idiopathic-pericarditis
#19
Aviv Mager, David Berger, Hadas Ofek, Yoav Hammer, Zaza Iakobishvili, Ran Kornowski
BACKGROUND: Myocardial involvement is common in acute idiopathic pericarditis and can, in some cases, lead to life-threatening complications. Acute idiopathic pericarditis is often preceded by various prodromal symptoms, but whether these symptoms can predict myocardial involvement is unclear. The aim of the study was to examine the value of different prodromal symptoms of acute idiopathic pericarditis for predicting myocardial involvement. METHODS AND RESULTS: Patients diagnosed with acute idiopathic pericarditis in 2007-2017 at our hospital were identified by database search...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29887947/agomelatine-protects-against-myocardial-ischemia-reperfusion-injury-by-inhibiting-mitochondrial-permeability-transition-pore-opening
#20
Pengyu Jia, Chunting Liu, Nan Wu, Dalin Jia, Yingxian Sun
Agomelatine is a melatonin (MT1/MT2) receptor agonist and serotonin (5-HT2C) receptor antagonist. To study the effects of agomelatine on myocardial ischemia reperfusion injury (MIRI), an isolated rat heart model was utilized. To induce MIRI, rat hearts were isolated and subjected to 30 min of ischemia followed by 120 min of reperfusion. Rats were intraperitoneally injected with agomelatine (10, 20 or 40 mg/kg) 1 h before heart isolation. Agomelatine (20 mg/kg and 40 mg/kg) significantly improved cardiac function, alleviated pathological changes in the ischemic myocardium, reduced myocardial infarct size and decreased release of creatine kinase-MB and lactate dehydrogenase...
2018: American Journal of Translational Research
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