keyword
https://read.qxmd.com/read/38536663/-it-s-opened-my-eyes-to-a-whole-new-world-positive-behaviour-support-training-for-staff-and-family-members-supporting-residents-with-dementia-in-aged-care-settings
#1
JOURNAL ARTICLE
Alinka C Fisher, Katrina Reschke, Nijashree Shah, Sau Cheung, Claire O'Connor, Olivier Piguet
OBJECTIVES: This study examined the acceptability and usefulness of Positive Behaviour Support (PBS) training in enhancing the capabilities of support staff and family members providing behaviour support to residents with dementia in residential aged care (RAC). METHODS: A mixed-methods pilot study was conducted across 3 RAC organisations, involving pre- and post-training questionnaire assessments for clinical leaders (n = 8), support staff (n = 37) and family members (n = 18)...
2024: American Journal of Alzheimer's Disease and Other Dementias
https://read.qxmd.com/read/38536471/prevalence-of-swallowing-disorder-in-different-dementia-subtypes-among-older-adults-a-meta-analysis
#2
JOURNAL ARTICLE
Alfiani Rahmi Putri, Yu-Hao Chu, Ruey Chen, Kai-Jo Chiang, Kondwani Joseph Banda, Doresses Liu, Hui-Chen Lin, Shu-Fen Niu, Kuei-Ru Chou
BACKGROUND: Ageing process and abnormal protein accumulation in dementia damage neural pathways affecting the swallowing process and leading to swallowing disorder. OBJECTIVE: To estimate the prevalence of swallowing disorder among older adults with different dementia subtypes. METHODS: We conducted a systematic search across multiple databases, including PubMed, Embase, Scopus, Web of Science and OVID Medline. The meta-analysis employed R (version 4...
March 1, 2024: Age and Ageing
https://read.qxmd.com/read/38535924/plasma-concentrations-of-high-mobility-group-box-1-proteins-and-soluble-receptors-for-advanced-glycation-end-products-are-relevant-biomarkers-of-cognitive-impairment-in-alcohol-use-disorder-a-pilot-study
#3
JOURNAL ARTICLE
Fernando Rodríguez de Fonseca, Francisco Medina-Paz, Mira Sapozhnikov, Isaac Hurtado-Guerrero, Leticia Rubio, Stella Martín-de-Las-Heras, Nerea Requena-Ocaña, María Flores-López, María Del Mar Fernández-Arjona, Patricia Rivera, Antonia Serrano, Pedro Serrano, Sara C Zapico, Juan Suárez
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and inflammation in the brain, activated by increased reactive oxygen/nitrogen species (ROS/RNS), advanced glycation end-products (AGEs) and high-mobility group box 1 protein (HMGB1). In a pilot study, we examine the potential clinical value of circulating biomarkers of oxidative stress including ROS/RNS, HMGB1, the soluble receptor for AGE (sRAGE), the brain biomarker of aging apolipoprotein D (ApoD), and the antioxidant regulator nuclear factor erythroid 2-related factor 2 (NRF2) as predictive indices for cognitive impairment (CI) in abstinent patients with AUD ( n = 25) compared to patients with established Alzheimer's disease (AD, n = 26) and control subjects ( n = 25)...
February 29, 2024: Toxics
https://read.qxmd.com/read/38535006/current-trends-and-applications-of-pet-mri-hybrid-imaging-in-neurodegenerative-diseases-and-normal-aging
#4
REVIEW
Jonathan Lee, Jonathan Renslo, Kasen Wong, Thomas G Clifford, Bryce D Beutler, Paul E Kim, Ali Gholamrezanezhad
Dementia is a significant global health issue that is exacerbated by an aging population. Imaging plays an established role in the evaluation of patients with neurocognitive disorders such as dementia. In current clinical practice, magnetic resonance imaging (MRI) and positron emission tomography (PET) are primary imaging modalities used separately but in concert to help diagnose and classify dementia. The clinical applications of PET/MRI hybrid imaging in dementia are an active area of research, particularly given the continued emergence of functional MRI (fMRI) and amyloid PET tracers...
March 10, 2024: Diagnostics
https://read.qxmd.com/read/38534798/a-protocol-for-evaluating-digital-technology-for-monitoring-sleep-and-circadian-rhythms-in-older-people-and-people-living-with-dementia-in-the-community
#5
JOURNAL ARTICLE
Ciro Della Monica, Kiran K G Ravindran, Giuseppe Atzori, Damion J Lambert, Thalia Rodriguez, Sara Mahvash-Mohammadi, Ullrich Bartsch, Anne C Skeldon, Kevin Wells, Adam Hampshire, Ramin Nilforooshan, Hana Hassanin, The Uk Dementia Research Institute Care Research Amp Technology Research Group, Victoria L Revell, Derk-Jan Dijk
Sleep and circadian rhythm disturbance are predictors of poor physical and mental health, including dementia. Long-term digital technology-enabled monitoring of sleep and circadian rhythms in the community has great potential for early diagnosis, monitoring of disease progression, and assessing the effectiveness of interventions. Before novel digital technology-based monitoring can be implemented at scale, its performance and acceptability need to be evaluated and compared to gold-standard methodology in relevant populations...
February 29, 2024: Clocks & Sleep
https://read.qxmd.com/read/38533734/the-association-between-physical-activity-and-cognition-in-a-racially-ethnically-diverse-cohort-of-older-adults-results-from-the-kaiser-healthy-aging-and-diverse-life-experiences-study
#6
JOURNAL ARTICLE
Mariana L Almeida, Anna M Pederson, Scott C Zimmerman, Ruijia Chen, Sarah Ackley, Alicia Riley, Chloe W Eng, Rachel A Whitmer, Kristen M George, Rachel L Peterson, Elizabeth Rose Mayeda, Paola Gilsanz, Dan M Mungas, Sarah Tomaszewski Farias, M Maria Glymour
OBJECTIVE: Most prior research on physical activity (PA) and cognition is based on predominantly white cohorts and focused on associations of PA with mean (average) cognition versus the distribution of cognition. Quantile regression offers a novel way to quantify how PA affects cognition across the entire distribution. METHODS: The Kaiser Healthy Aging and Diverse Life Experiences study includes 30% white, 19% black, 25% Asian, and 26% Latinx adults age 65+ living in Northern California (n = 1600)...
March 27, 2024: Alzheimer Disease and Associated Disorders
https://read.qxmd.com/read/38533723/substance-use-problems-and-disorders-among-adults-50-years-and-older-receiving-mental-health-treatment-for-a-primary-neurocognitive-disorder
#7
JOURNAL ARTICLE
Orrin D Ware, Sol Baik, Todd D Becker, Hannah Neukrug, Sheryl Zimmerman
OBJECTIVES: This study sought to (1) identify the percentage of high-risk substance use or substance use disorder (SUD) and (2) examine the factors associated with high-risk substance use or SUD in adults aged 50 years and older receiving mental health treatment with a primary delirium or dementia diagnosis. METHOD: This study used 7 years (2013-2019) of national administrative data on community mental health center patients aged 50 years and older with a primary delirium or dementia diagnosis receiving treatment in the United States (U...
March 27, 2024: Aging & Mental Health
https://read.qxmd.com/read/38533683/molecular-networking-guided-investigation-of-the-secondary-metabolome-of-four-morus-species-and-their-in-vivo-neuroprotective-potential-for-the-mitigation-of-alzheimer-s-disease
#8
JOURNAL ARTICLE
Nesrine M Hegazi, Tarik A Mohamed, Abeer Salama, Ahmed R Hamed, Hamada H Saad, Ibrahim A Saleh, Eman H Reda, Ahmed A A Elsayed, Mahmoud A A Ibrahim, Paul W Paré, Thomas Efferth, Mohamed-Elamir F Hegazy
Alzheimer's Disease (AD) is a fatal age-related neurodegenerative condition with a multifactorial etiology contributing to 70% of dementia globally. The search for a multi-target agent to hit different targets involved in the pathogenesis of AD is crucial. In the present study, the neuroprotective effects of four Morus extracts were assessed in LPS-induced AD in mice. Among the studied species, M. macroura exhibited a profound effect on alleviating the loss of cognitive function, improved the learning ability, restored the acetylcholine esterase (AChE) levels to normal, and significantly reduced the tumor necrosis factor alpha (TNF-α) brain content in LPS-treated mice...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38533619/amyloid-pathology-mediates-the-associations-between-plasma-fibrinogen-and-cognition-in-non-demented-adults
#9
JOURNAL ARTICLE
Li-Yun Ma, Jing-Hui Song, Pei-Yang Gao, Ya-Nan Ou, Yan Fu, Liang-Yu Huang, Zuo-Teng Wang, Dan-Dan Zhang, Rui-Ping Cui, Yin-Chu Mi, Lan Tan
Though previous studies revealed the potential associations of elevated levels of plasma fibrinogen with dementia, there is still limited understanding regarding the influence of Alzheimer's disease (AD) biomarkers on these associations. We sought to investigate the interrelationships among fibrinogen, cerebrospinal fluid (CSF) AD biomarkers, and cognition in non-demented adults. We included 1996 non-demented adults from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study and 337 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database...
March 27, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38532827/biomarkers-of-chronic-inflammation-and-cognitive-decline-a-prospective-observational-study
#10
JOURNAL ARTICLE
Bhavna A Guduguntla, Alexi Vasbinder, Elizabeth Anderson, Tariq U Azam, Pennelope Blakely, Noah J Webster, Richard Gonzalez, Toni Atonucci, Judith L Heidebrink, Bruno Giordani, Laura Zahodne, Benjamin M Hampstead, Kristine J Ajrouch, Salim S Hayek
We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C-reactive protein (hs-CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs-CRP levels were not significantly higher in participants with mild cognitive impairment ( n  = 97) or dementia ( n  = 59), compared to those with normal cognitive function ( n  = 126)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38531951/interrogation-of-the-human-cortical-peptidome-uncovers-cell-type-specific-signatures-of-cognitive-resilience-against-alzheimer-s-disease
#11
JOURNAL ARTICLE
G R Morgan, B C Carlyle
Alzheimer's disease (AD) is characterised by age-related cognitive decline. Brain accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD diagnosis, yet up to one-third of AD-pathology positive community-dwelling elderly adults experience no symptoms of cognitive decline during life. Conversely, some exhibit chronic cognitive impairment in absence of measurable neuropathology, prompting interest into cognitive resilience-retained cognition despite significant neuropathology-and cognitive frailty-impaired cognition despite low neuropathology...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531695/increased-trend-in-dementia-incidence-within-a-taiwanese-national-cohort-what-have-we-learned-what-can-we-do
#12
EDITORIAL
Davide Angioni, Pierre-Jean Ousset, Bruno Vellas
No abstract text is available yet for this article.
March 16, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38531675/development-and-internal-validation-of-a-dynamic-fall-risk-prediction-and-monitoring-tool-in-aged-care-using-routinely-collected-electronic-health-data-a-landmarking-approach
#13
JOURNAL ARTICLE
Nasir Wabe, Isabelle Meulenbroeks, Guogui Huang, Sandun Malpriya Silva, Leonard C Gray, Jacqueline C T Close, Stephen Lord, Johanna I Westbrook
OBJECTIVES: Falls pose a significant challenge in residential aged care facilities (RACFs). Existing falls prediction tools perform poorly and fail to capture evolving risk factors. We aimed to develop and internally validate dynamic fall risk prediction models and create point-based scoring systems for residents with and without dementia. MATERIALS AND METHODS: A longitudinal cohort study using electronic data from 27 RACFs in Sydney, Australia. The study included 5492 permanent residents, with a 70%-30% split for training and validation...
March 26, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38531510/age-related-changes-in-species-typical-behaviours-in-the-5xfad-mouse-model-of-alzheimer-s-disease-from-4-16-months-of-age
#14
JOURNAL ARTICLE
Timothy P O'Leary, Richard E Brown
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform activities of daily living and the decline in these activities is related to the severity of neurobiological deterioration underlying the disease. The 5xFAD mouse model of AD shows age-related impairments in sensory- motor and cognitive function, but little is known about changes in species-typical behaviours that may model activities of daily living in AD patients. Therefore, we examined species-typical behaviours used as indices of exploration (rearing) and compulsivity (grooming) across six tests of anxiety-like behaviour or motor function in female 5xFAD mice from 3-16 months of age...
March 24, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38531337/informal-care-time-and-costs-of-dementia-care-in-benin-west-africa
#15
JOURNAL ARTICLE
Angeladine Kenne Malaha, Clémence Thébaut, Dismand Stephan Houinato, Grégoire Magloire Gansou, Dieu Donné Gnonlonfoun, Thierry Adoukonou, Pierre-Marie Preux, Maëlenn Guerchet
BACKGROUND: Dementia is a growing global health challenge, with significant socioeconomic implications. This study examined the informal care duration and related costs along with the total cost of care for older individuals with dementia in Benin, West Africa, providing insights into a region with limited dementia research. METHODS: We conducted a cost-of-illness study in Benin. Both hospital and community recruitments were used to enroll adults aged ≥ 60 years and their primary caregivers...
March 26, 2024: Neuroepidemiology
https://read.qxmd.com/read/38531336/physical-activity-moderates-the-relationship-between-cardiovascular-disease-risk-burden-and-cognition-in-older-adults
#16
JOURNAL ARTICLE
Sandra T Nguyen, Jing Guo, Suhang Song, Dolly Reyes-Dumeyer, Danurys Sanchez, Adam M Brickman, Jennifer J Manly, Nicole Schupf, Rafael A Lantigua, Richard P Mayeux, Yian Gu
Introduction Older individuals with higher cardiovascular disease (CVD) burden have a higher risk for accelerated cognitive decline and dementia. Physical activity (PA) is an inexpensive and accessible preventive measure to CVD, cognitive impairment, and dementia. The current study examined (1) whether PA moderates the relationship between CVD burden and cognition and (2) whether the moderating effect of PA differs by race/ethnicity groups and by APOE-ɛ4 status. Methods Our cross-sectional study included participants from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a multi-ethnic, community-based, longitudinal study on aging and dementia among individuals aged 65 years and older who reside in northern Manhattan...
March 26, 2024: Neuroepidemiology
https://read.qxmd.com/read/38531174/effect-of-increasing-cognitive-activity-participation-on-default-mode-network-in-older-adults-with-subjective-cognitive-decline-a-randomised-controlled-trial
#17
JOURNAL ARTICLE
Allen Ting Chun Lee, Yishan Luo, Zhaohua Huo, Lin Shi, Winnie Chiu Wing Chu, Linda Chiu Wa Lam
BACKGROUND: Having more cognitive activities may prevent dementia, but its evidence of modulating the functional brain network is limited. This randomised controlled trial (RCT) investigated the effect of increased cognitive activity participation on the default mode network (DMN) in older adults who had already been having regular cognitive activity participation and experiencing subjective cognitive decline (SCD). METHODS: Community-living Chinese individuals aged 55-75 years with regular practice of Chinese calligraphy and screened positive for SCD (but negative for mild cognitive impairment or dementia) were randomly allocated to either the intervention or control group...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38531149/the-social-and-cognitive-online-training-scot-project-a-digital-randomized-controlled-trial-to-promote-socio-cognitive-well-being-in-older-adults
#18
JOURNAL ARTICLE
Giulia Funghi, Claudia Meli, Arianna Cavagna, Lisa Bisoffi, Francesca Zappini, Costanza Papagno, Alessandra Dodich
OBJECTIVES: Effective prevention programs targeting risk factors for cognitive decline in the elderly are recommended given the progressive increase in the aging of the general population. The Social and Cognitive Online Training (SCOT) project is a randomized, controlled, parallel clinical trial designed to prevent the age-related decline in executive and social functions. METHODS: The study included 60 cognitively healthy older adults (age = 71.8±5.3, education = 12...
March 5, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38530864/associations-between-onset-age-of-orthostatic-hypotension-and-incident-myocardial-infarction-stroke-and-dementia-a-prospective-cohort-study
#19
JOURNAL ARTICLE
Jie Liang, Wenya Zhang, Yang Pan, Darui Gao, Yongqian Wang, Wuxiang Xie, Fanfan Zheng
BACKGROUND: The associations of age at orthostatic hypotension onset with incident myocardial infarction (MI), stroke, and dementia remain unknown. This study aimed to examine whether younger onset age of orthostatic hypotension was associated with higher risks of incident MI, stroke, and dementia. METHODS: Data were obtained from the UK Biobank. Information on the diagnosis of orthostatic hypotension, MI, stroke, and dementia was collected at baseline (2006-2010) and follow-ups (median=13 years)...
March 26, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38530577/bajitianwan-formula-extract-ameliorates-bone-loss-induced-by-iron-overload-via-activating-rage-pi3k-akt-pathway-based-on-network-pharmacology-and-transcriptomic-analysis
#20
JOURNAL ARTICLE
Weifan Xu, Tao Jiang, Luying Ding, Yiping Jiang, Lichao Zhang, Tianshuang Xia, Hailiang Xin
Osteoporosis (OP) is closely related to iron overload. Bajitianwan (BJTW) is a traditional Chinese medicine formulation used for treating senile diseases such as dementia and osteoporosis. Modern pharmacological researches have found that BJTW has beneficial effect on bone loss and memory impairment in aging rats. This paper aimed to explore the role and mechanism of BJTW in ameliorating iron overload-induced bone loss. Furthermore, BJTW effectively improved the bone micro-structure of the femur in mice, and altered bone metabolism biomarkers alkaline phosphatase (ALP) and osteocalcin (OCN) in serum, as well as oxidative indexes superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) glutathione (GSH) and malondialdehyde (MDA) in liver...
March 26, 2024: Journal of Natural Medicines
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