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https://www.readbyqxmd.com/read/29793191/development-and-validation-of-a-prediction-model-for-functional-decline-in-older-medical-inpatients
#1
Toshihiko Takada, Shingo Fukuma, Yosuke Yamamoto, Yukio Tsugihashi, Hiroyuki Nagano, Michio Hayashi, Jun Miyashita, Teruhisa Azuma, Shunichi Fukuhara
OBJECTIVE: To prevent functional decline in older inpatients, identification of high-risk patients is crucial. The aim of this study was to develop and validate a prediction model to assess the risk of functional decline in older medical inpatients. METHODS: In this retrospective cohort study, patients ≥65 years admitted acutely to medical wards were included. The healthcare database of 246 acute care hospitals (n = 229,913) was used for derivation, and two acute care hospitals (n = 1767 and 5443, respectively) were used for validation...
May 17, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29792874/pet-staging-of-amyloidosis-using-striatum
#2
Bernard J Hanseeuw, Rebecca A Betensky, Elizabeth C Mormino, Aaron P Schultz, Jorge Sepulcre, John A Becker, Heidi I L Jacobs, Rachel F Buckley, Molly R LaPoint, Patrizia Vanini, Nancy J Donovan, Jasmeer P Chhatwal, Gad A Marshall, Kathryn V Papp, Rebecca E Amariglio, Dorene M Rentz, Reisa A Sperling, Keith A Johnson
INTRODUCTION: Amyloid PET data are commonly expressed as binary measures of cortical deposition. However, not all individuals with high cortical amyloid will experience rapid cognitive decline. Motivated by postmortem data, we evaluated a three-stage PET classification: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid; hypothesizing this model could better reflect Alzheimer's dementia progression than a model based only on cortical measures. METHODS: We classified PET data from 1433 participants (646 normal, 574 mild cognitive impairment, and 213 AD), explored the successive involvement of cortex and striatum using 3-year follow-up PET data, and evaluated the associations between PET stages, hippocampal volumes, and cognition...
May 21, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29792390/mental-health-crisis-resolution-teams-and-crisis-care-systems-in-england-a-national-survey
#3
Brynmor Lloyd-Evans, Danielle Lamb, Joseph Barnby, Michelle Eskinazi, Amelia Turner, Sonia Johnson
Aims and methodA national survey investigated the implementation of mental health crisis resolution teams (CRTs) in England. CRTs were mapped and team managers completed an online survey. RESULTS: Ninety-five per cent of mapped CRTs (n = 233) completed the survey. Few CRTs adhered fully to national policy guidelines. CRT implementation and local acute care system contexts varied substantially. Access to CRTs for working-age adults appears to have improved, compared with a similar survey in 2012, despite no evidence of higher staffing levels...
May 24, 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29792155/design-synthesis-and-investigation-of-new-diphenyl-substituted-pyridazinone-derivatives-as-both-cholinesterase-and-a%C3%AE-aggregation-inhibitors
#4
Burcu Kilic, Merve Erdogan, Hayrettin O Gulcan, Fatma Aksakal, Nihan Oruklu, E Umit Bagriacik, Deniz S Dogruer
Backround: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses. OBJECTIVE: In this study, three series of diphenyl-2-(2-(4-substitutedpiperazin-1-yl)ethyl)pyridazin-3(2H)-one derivatives were designed, synthesized and investigated for their ability to inhibit both cholinesterase enzymes and amyloid-β aggregation...
May 23, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29790571/-epidemiology-of-alzheimer-s-disease-and-other-dementias
#5
REVIEW
J Garre-Olmo
INTRODUCTION: Dementia is a clinical syndrome resulting from a number of causations and which is usually accompanied by progressive and diffuse brain dysfunction. The different subtypes are characterised by a clinical picture with common symptoms that differ in terms of their aetiology, age, clinical presentation, clinical course and associated disorders. AIM: To present an update on the information available about the descriptive epidemiology of dementia and its main subtypes...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29789049/the-impact-of-cholinesterase-inhibitors-with-or-without-memantine-on-antipsychotic-prescribing
#6
Amie Taggart Blaszczyk, Belinda Hong Mang, Hennie Garza, Monica Mathys
Background Alzheimer's disease (AD) medications have been suggested to positively affect behavior, though not universally in all studies. Their impact on antipsychotic use is not well-defined. Methods This cross-sectional, retrospective study evaluated residents with AD on cholinesterase inhibitors, memantine, both, or neither throughout multiple long-term care facilities during July 2014. Patients were included if they: were between 65 and 89 years of age, had a diagnosis of AD, and had a cognitive assessment within three months of the study period...
May 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29788900/association-between-vascular-comorbidity-and-progression-of-alzheimer-s-disease-a-two-year-observational-study-in-norwegian-memory-clinics
#7
Rannveig Sakshaug Eldholm, Karin Persson, Maria Lage Barca, Anne-Brita Knapskog, Lena Cavallin, Knut Engedal, Geir Selbaek, Eva Skovlund, Ingvild Saltvedt
BACKGROUND: Vascular risk factors increase the risk of Alzheimer's disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of this study was to examine the association between vascular disease and vascular risk factors and progression of AD. METHODS: In a longitudinal observational study in three Norwegian memory clinics, 282 AD patients (mean age 73.3 years, 54% female) were followed for mean 24 (16-37) months...
May 22, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29788097/hypertension-treatment-for-older-people-navigating-between-scylla-and-charybdis
#8
Simon Paul Conroy, Rudi Gerardus Johannes Westendorp, Miles D Witham
Hypertension is a common condition in older people, but is often one of many conditions, particularly in frail older people, and so is rarely managed in isolation in the real world-which belies the bulk of the evidence upon which is treatment decisions are often based. In this article, we discuss the issues of ageing, including frailty and dementia, and their impact upon blood pressure management. We examine the evidence base for managing hypertension in older people, and explore some therapeutic ideas that might influence treatment decisions and strategies, including shared decision making...
May 21, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29787954/the-effectiveness-of-a-cognitive-training-program-in-people-with-mild-cognitive-impairment-a-study-in-urban-community
#9
Chalermpong Sukontapol, Sasithorn Kemsen, Sirintorn Chansirikarn, Daochompu Nakawiro, Orawan Kuha, Unchulee Taemeeyapradit
OBJECTIVE: To assess the effectiveness of a cognitive training program on global cognition among people with mild cognitive impairment. METHODS: In this experimental study, using purposive sampling, 60 participants age 50 years and over who complained of subjective memory impairment were screened in their communities by public health volunteers with the Abbreviated Mental Test. Those with dementia were excluded as well as those with depression, which were screened out by the Thai Geriatric Depression Scale (TGDS-15)...
May 19, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29787630/people-with-dementia-getting-lost-in-australia-dementia-related-missing-person-reports-in-the-media
#10
Margaret MacAndrew, Linda Schnitker, Nicole Shepherd, Elizabeth Beattie
OBJECTIVE: This study aimed to understand the circumstances in which people with dementia become lost, and the outcomes of these incidents. METHODS: A search was conducted of news articles published in Australia between 2011 and 2015 reporting a missing person with a diagnosis of dementia. RESULTS: Over the five-year period, 130 missing person cases were reported. The average age of the missing person was 75 years with more men (74%) than women reported missing...
May 22, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29786922/finding-factors-that-predict-treatment-resistant-depression-results-of-a-cohort-study
#11
M Soledad Cepeda, Jenna Reps, Patrick Ryan
BACKGROUND: Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment-resistant depression (TRD). Predicting who will develop TRD may help healthcare providers make more effective treatment decisions. We sought to identify factors that predict TRD in a real-world setting using claims databases. METHODS: A retrospective cohort study was conducted in a US claims database of adult subjects with newly diagnosed and treated depression with no mania, dementia, and psychosis...
May 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29786916/herbal-medicine-as-a-promising-therapeutic-approach-for-the-management-of-vascular-dementia-a-systematic-literature-review
#12
REVIEW
Adel Ghorani-Azam, Samaneh Sepahi, Elham Khodaverdi, Seyed Ahmad Mohajeri
Vascular dementia (VaD) generally refers to memory deficits and cognitive abnormalities that are resulted from vascular disease. In this study, we aimed to systematically review the literature wherein therapeutic effects of medicinal plants have been studied on VaD. A systematic literature search was performed in the PubMed, Scopus, Web of Science, Google Scholar, and other databases using VaD, and medicinal plants as key terms. No strict inclusion criteria were defined, and almost all clinical studies were included...
May 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29786594/-brain-microbleeds-definition-pathophysiology-and-the-consequences
#13
Marek Mazurek, Ewa Papuć, Konrad Rejdak
Brain microbleeds are defined as small, circular hypointense changes in T2-sequensec of brain MRI, well demarcated from the surrounding tissue. They represent the phagocytized products of blood distribution extravasated from pathologically altered vessels. The echo-T2-dependent gradient (GRE) and magnetic susceptibility testing (SWI) sequences are usually used to visualize them. The pathogenesis of microbleeds very complex but angiopathy associated with arterial hypertension and cerebral amyloid angiopathy play a special role...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785803/depressive-spectrum-states-in-a-population-based-cohort-of-70-year-olds-followed-over-9-years
#14
Robert Sigström, Margda Waern, Pia Gudmundsson, Ingmar Skoog, Svante Östling
OBJECTIVE: Depression may be understood as a spectrum of more or less symptomatic states. Little is known about the long-term course of these states in older populations. We examined the prevalence and course of depressive states of different severity in a Swedish population sample of older people followed over 9 years. METHODS: A population-based sample of 70-year olds without dementia (N = 563, response rate 71.1%) underwent a psychiatric examination; 450 survivors without dementia were reexamined at ages 75 and/or 79 years...
May 21, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29785228/evaluating-the-utility-of-a-structured-clinical-protocol-for-reducing-the-impact-of-behavioural-and-psychological-symptoms-of-dementia-in-progressive-neurological-diseases-a-pilot-study
#15
Nicholas P Ryan, Laura Scott, Maryanne McPhee, Susan Mathers, Marie-Claire Davis, Roxanne Maule, Fiona Fisher
Objectives: Behavioural and psychological symptoms of dementia (BPSD) cause significant distress to both aged care residents and staff. Despite the high prevalence of BPSD in progressive neurological diseases (PNDs) such as multiple sclerosis, Huntington's disease, and Parkinson's disease, the utility of a structured clinical protocol for reducing BPSD has not been systematically evaluated in PND populations. Method: Staff ( n = 51) and individuals with a diagnosis of PND ( n = 13) were recruited into the study, which aimed to evaluate the efficacy of a PND-specific structured clinical protocol for reducing the impact of BPSD in residential aged care (RAC) and specialist disability accommodation (SDA) facilities...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29784047/memory-related-subjective-cognitive-symptoms-in-the-adult-population-prevalence-and-associated-factors-results-of-the-life-adult-study
#16
Tobias Luck, Susanne Roehr, Francisca S Rodriguez, Matthias L Schroeter, A Veronica Witte, Andreas Hinz, Anja Mehnert, Christoph Engel, Markus Loeffler, Joachim Thiery, Arno Villringer, Steffi G Riedel-Heller
BACKGROUND: Subjectively perceived memory problems (memory-related Subjective Cognitive Symptoms/SCS) can be an indicator of a pre-prodromal or prodromal stage of a neurodegenerative disease such as Alzheimer's disease. We therefore sought to provide detailed empirical information on memory-related SCS in the dementia-free adult population including information on prevalence rates, associated factors and others. METHODS: We studied 8834 participants (40-79 years) of the population-based LIFE-Adult-Study...
May 21, 2018: BMC Psychology
https://www.readbyqxmd.com/read/29782317/dementia-research-populations-progress-problems-and-predictions
#17
Sally Hunter, Nadja Smailagic, Carol Brayne
Alzheimer's disease (AD) is a clinicopathologically defined syndrome leading to cognitive impairment. Following the recent failures of amyloid-based randomized controlled trials to change the course of AD, there are growing calls for a re-evaluation of basic AD research. Epidemiology offers one approach to integrating the available evidence. Here we examine relationships between evidence from population-based, clinicopathological studies of brain aging and a range of hypotheses from all areas of AD research...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782310/putative-gonadotropin-releasing-hormone-agonist-therapy-and-dementia-an-application-of-medicare-hospitalization-claims-data
#18
Mark A Smith, Richard L Bowen, Richard Q Nguyen, George Perry, Craig S Atwood, Alfred A Rimm
BACKGROUND: Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. OBJECTIVE: To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29781774/a-perfect-storm-challenges-encountered-by-family-caregivers-of-persons-with-alzheimer-s-disease-during-natural-disasters
#19
Allison Gibson, Jessica Walsh, Lisa M Brown
Since Hurricane Katrina there has been a movement across the U.S. to examine best practice for disaster response within the aging population. However, little is known about the experience of natural disasters from the perspective of family caregivers of persons with Alzheimer's disease and related dementia (ADRD). In this exploratory, qualitative study, family caregivers (n=27) were interviewed about their experience with the historic 2015 South Carolina flood. By using thematic analysis, themes were identified to better understand what unique challenges caregivers of person with ADRD experienced...
May 21, 2018: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29781725/the-effects-of-an-expanded-cognitive-stimulation-therapy-model-on-the-improvement-of-cognitive-ability-of-elderly-with-mild-stage-dementia-living-in-a-community-a-randomized-waitlist-controlled-trial
#20
Daniel Kim-Wan Young, Petrus Yat-Nam Ng, Timothy Kwok, Florence Ho, Daphne Cheng, Vivan Mak, Andrew Lau
OBJECTIVE: This research study aims to evaluate the effectiveness of an expanded cognitive stimulation therapy (CST) model that combines a CST group and tai chi on improving the cognitive ability of community-dwelling Chinese elderly with mild stage dementia (EwMD). METHOD: A randomized waitlist controlled trial design was adopted in this study. The treatment group participated in a structured CST group followed by tai chi twice a week, with a total of 14 sessions throughout the study period...
May 21, 2018: Aging & Mental Health
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