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femoral head necrosis

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https://www.readbyqxmd.com/read/28913399/reactive-scoliosis-a-challenging-phenomenon-in-adolescent-patients-with-hip-arthritis
#1
Madhav Chowdhry, Laura Matsen Ko, Corinna Franklin, Javad Parvizi
Functional limb length discrepancy (LLD) in adolescents can result from soft tissue contracture following long-standing hip disease. We present a case of a 13-year-old girl with difficulty in ambulation due to right hip pain and LLD. Radiographs revealed severe arthritis of right hip with signs of avascular necrosis of the femoral head. The patient had developed reactive scoliosis of lumbar spine along with pelvic obliquity. After failing conservative management, total hip arthroplasty (THA) without attempting to equalize LLD was performed...
September 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28900820/outcome-of-childhood-leukaemia-survivors-and-necrosis-of-the-femoral-head-treated-with-autologous-mesenchymal-stem-cells
#2
T de Rojas, S Martínez-Álvarez, S Lerma-Lara, M Á Díaz, L Madero, M Ramírez
PURPOSE: Corticoid-induced osteonecrosis (ON) of femoral head can lead to severe hip joint impairment and hip replacement, with negative impact in young survivors of acute lymphoblastic leukaemia (ALL) with long life expectancy. We aim to improve quality of life in these patients with a novel approach. METHODS/PATIENTS: Based on the regenerative capacities of mesenchymal stem cells (MSCs), we performed locally implanted autologous cell therapy in two adolescents suffering of bilateral femoral ON...
September 12, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28882372/reduced-survival-for-uncemented-compared-to-cemented-total-hip-arthroplasty-after-operatively-treated-acetabular-fractures
#3
John Clarke-Jenssen, Marianne Westberg, Olav Røise, Stein Arne Øvre Storeggen, Tone Bere, Ingunn Silberg, Jan Erik Madsen
BACKGROUND: Post traumatic arthritis and avascular necrosis of the femoral head are common complications after operatively treated acetabular fractures. This may cause severe disabilities for the patient, necessitating a total hip arthroplasty. Even though an arthroplasty may provide good symptomatic relief, the long-term results are more uncertain and no consensus exists according to preferred prosthetic designs. With this cohort study, we aimed to investigate the medium to long term arthroplasty survival and clinical results of total hip arthroplasty after operatively treated acetabular fractures...
September 4, 2017: Injury
https://www.readbyqxmd.com/read/28878383/avascular-necrosis-of-femoral-head-a-metabolomic-biophysical-biochemical-electron-microscopic-and-histopathological-characterization
#4
Aswath Narayanan, Prakash Khanchandani, Roshan M Borkar, Chandrashekar Reddy Ambati, Arun Roy, Xu Han, Ritesh N Bhoskar, Srinivas Ragampeta, Francis Gannon, Vijaya Mysorekar, Balasubramanyam Karanam, Sai Muthukumar V, Venketesh Sivaramakrishnan
Avascular necrosis of the femur head (AVNFH) is a debilitating disease caused due to the use of alcohol, steroids, following trauma or unclear (idiopathic) etiology, affecting mostly the middle aged population. Clinically AVNFH is associated with impaired blood supply to the femoral head resulting in bone necrosis and collapse. Although Homocysteine (HC) has been implicated in AVNFH, levels of homocysteine and its associated pathway metabolites have not been characterized. We demonstrate elevated levels of homocysteine and concomitantly reduced levels of vitamins B6 and B12, in plasma of AVNFH patients...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877384/exosomes-secreted-from-mutant-hif-1%C3%AE-modified-bone-marrow-derived-mesenchymal-stem-cells-attenuate-early-steroid-induced-avascular-necrosis-of-femoral-head-in-rabbit
#5
Haile Li, Danping Liu, Chen Li, Shanjian Zhou, Dachuan Tian, Dawei Xiao, Huan Zhang, Feng Gao, Jianhua Huang
Mesenchymal stem cells (MSCs)-derived exosomes exhibit protective effects on damaged or diseased tissues. Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in bone development. However, HIF-1α is easily biodegradable under normoxic conditions. The bone-marrow-derived mesenchymal stem cells (BMSCs) were transfected with adenovirus carrying triple point-mutations (amino acids 402, 564, and 803) in the HIF-1α coding sequence (CDS). The mutant HIF-1α can efficiently express functional proteins under normoxic conditions...
September 6, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28861192/comparison-of-outcomes-of-total-hip-arthroplasty-between-patients-with-ankylosing-spondylitis-and-avascular-necrosis-of-the-femoral-head
#6
Sun-Ho Lee, Gun-Woo Lee, Young-Jun Seol, Kyung-Soon Park, Taek-Rim Yoon
BACKGROUND: The objective of this study was to compare clinical and radiological outcomes of total hip arthroplasty (THA) between ankylosing spondylitis (AS) of the hip joint and avascular necrosis (AVN) of the femoral head. METHODS: Thirty patients (30 hips) underwent cementless THA for AS between 2003 and 2012. They were compared to 30 patients (30 hips) who underwent the same procedure for AVN of the femoral head. Each group was matched for age and gender, and both groups had similar preoperative demographic characteristics...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28844681/dynamic-hip-system-blade-versus-cannulated-compression-screw-for-the-treatment-of-femoral-neck-fractures-a-retrospective-study
#7
Chao Chen, Li Yu, Xin Tang, Mo-Zhen Liu, Li-Zhong Sun, Changjian Liu, Zhen Zhang, Chang-Zhou Li
OBJECTIVE: The aim of this study was to compare clinical outcomes of patients with femoral neck fractures treated with the dynamic hip system blade (DHS-BLADE) or cannulated compression screws. METHODS: Eighty-six patients with femoral neck fractures were treated by closed reduction internal fixation with a DHS-BLADE (n = 42; 18 males and 24 females; mean age: 56.3 years (37-87)) or cannulated compression screws (n = 44; 20 males and 24 females; mean age: 53...
August 24, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28844125/stem-cell-therapy-for-avascular-necrosis-of-femoral-head-in-sickle-cell-disease-report-of-11-cases-and-review-of-literature
#8
Mir Sadat-Ali, Md Q Azam, Ezzat M Elshabouri, Ahmad M Tantawy, Sadananda Acharya
Background and Objective: Sickle cell disease (SCD) is quite common in eastern Saudi Arabia and Avascular necrosis of femoral head (ANFH) occurs in 30% of the young patients leading to early joint arthroplasty. This study was conducted to assess the benefits of injection of osteoblasts in the avascular lesions of the head of femur. Patients and Methods: A preset technique was used, 10 CC of bone marrow aspiration was performed under local anesthesia and aseptic technique...
August 31, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28840126/autologous-stem-cells-combined-core-decompression-for-treatment-of-avascular-necrosis-of-the-femoral-head-a-systematic-meta-analysis
#9
REVIEW
Shibing Xu, Lei Zhang, Hongting Jin, Letian Shan, Li Zhou, Luwei Xiao, Peijian Tong
OBJECTIVE: This study aims to systematically evaluate the efficacy and safety of core decompression combined transplantation of autologous bone marrow stem cells (CDBMSCs) for treatment of avascular necrosis of the femoral head (ANFH). METHODS: Randomized controlled trials (RCTs) regarding effectiveness of core decompression combined transplantation of autologous bone marrow stem cells for treating ANFH were searched in 8 comprehensive databases prior to September 2016...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811788/clinical-results-of-femoral-head-fracture-dislocation-treated-according-to-the-pipkin-classification
#10
Xiao Yu, Qing-Jiang Pang, Xian-Jun Chen
OBJECTIVE: To summarize the clinical results of femoral head fracture-dislocation treated according to Pipkin classification. METHODS: Atotal of 19 patients with femoral head fracture-dislocation were retrospectively analyzed from Mar. 2008 to Mar. 2015. According to the classification of Pipkin criteria, there were 4 cases in Type-I, 6 cases in Type-II, 6 cases in Type-IIIand 3 cases in Type-IV. Various procedures were taken according to the different types of the fracture, the time of the fracture, and the age of the patients...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28802420/dhs-osteosynthesis-with-internal-bone-grafting-in-unstable-delayed-presented-intracapsular-neck-femur-fractures
#11
Wasudeo M Gadegone, R M Chandak, Vijayanand R Lokhande
OBJECTIVES: The aim of this study was to assess fracture union and complications following use of dynamic hip screw (DHS) with internal bone grafting in treatment of unstable delayed presented intracapsular neck femur fractures in patients younger than 65 years of age. MATERIAL AND METHODS: Thirty two patients with displaced intracapsular neck femur fractures(Garden III and IV, Pauwels III, with comminution) with delayed presentation (15-60 days) in the 45-65 year age group (mean 54...
August 2017: Injury
https://www.readbyqxmd.com/read/28798870/histopathological-and-imageological-studies-on-clinical-outcomes-of-mineralized-collagen-reconstruction-rod-for-femoral-head-necrosis-with-one-case-report
#12
Baogang Xie, Hao Wang, Jianhua Hao, Ping Wang, Na Zhang, Jingjing Wu, Zhiye Qiu, Fuzhai Cui
In this article, the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological methods. Computed radiography (CR) computerized tomography (CT), common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head, interface between the host bone and implant and the bone reconstruction process. The results showed that the density of rods increased closed to that of host bones after 1 year implanting, and the interface between them turns to blurring...
August 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28797104/increased-microrna-93-5p-inhibits-osteogenic-differentiation-by-targeting-bone-morphogenetic-protein-2
#13
Ying Zhang, Qiu-Shi Wei, Wei-Bin Ding, Lei-Lei Zhang, Hui-Chao Wang, Ying-Jie Zhu, Wei He, Yu-Na Chai, You-Wen Liu
BACKGROUND AND PURPOSE: Trauma-induced osteonecrosis of the femoral head (TIONFH) is a major complication of femoral neck fractures. Degeneration and necrosis of subchondral bone can cause collapse, which results in hip joint dysfunction in patients. The destruction of bone metabolism homeostasis is an important factor for osteonecrosis. MicroRNAs (miRNAs) have an important role in regulating osteogenic differentiation, but the mechanisms underlying abnormal bone metabolism of TIONFH are poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/28790551/bilateral-subcapital-femoral-neck-fracture-in-a-28-year-old-postpartum-woman
#14
Miroslav Kezunovic, Nikola Bulatovic, Vojin Kadic
INTRODUCTION: Subcapital femoral neck fractures are associated with high morbidity and mortality. These fractures mostly occur as a result of a high-force impact from traffic accidents and a fall from a great height, though non-traumatic forms are described in transient osteoporosis during the second half of pregnancy, in convulsions during electric shock, eclampsia, hypocalcemia, osteomalacia, renal osteodystrophy and myeloma. CASE REPORT: In this report we present a bilateral subcapital femoral neck fracture in a woman sustained two days after delivery...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28776544/quantitative-evaluation-of-pain-with-pain-index-extracted-from-electroencephalogram
#15
Jian-Xiong An, Yong Wang, Doris K Cope, John P Williams
BACKGROUND: The current pain assessment methods are strongly subjective and easily affected by outside influences, and there is an urgent need to develop a reliable objective and quantitative pain-monitoring indicator. The aim of this study was to evaluate the feasibility of using Pain index (Pi) to assess pain symptoms in pain patients. METHODS: Subjects were enrolled from patients seeking treatment at Pain Medicine Center of China Medical University Aviation General Hospital from October 2015 to December 2016, such as postherpetic neuralgia, spinal cord injury, femoral head necrosis, lumbar disc herniation, trigeminal neuralgia, complex regional pain syndrome, perineal pain, phantom limb pain, etc...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28774681/sildenafil-improves-blood-perfusion-in-steroid-induced-avascular-necrosis-of-femoral-head-in-rabbits-via-a-protein-kinase-g-dependent-mechanism
#16
Qichun Song, Jianlong Ni, Hongyuan Jiang, Zhibin Shi
OBJECTIVE: The aim of the study were to evaluate the effect of sildenafil against avascular necrosis of femoral head (ANFH) in a rabbit model, and to study the role of protein kinase G (PKG) pathway and vascular endothelial growth factor (VEGF) in ANFH. METHODS: Three weeks after inducing ANFH with methylprednisolone injection, 45 female adult New Zealand white rabbits were divided into three groups and treated as follows: group SI received daily intraperitoneal sildenafil with a dose of 10 mg/kg per day; group SD received daily sildenafil identically to group SI plus auricular vein injection DT3 (a specific PKG inhibitor); group NS received only normal saline...
July 31, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28768791/the-correlation-between-salter-s-criteria-for-avascular-necrosis-of-the-femoral-head-and-kalamchi-s-prognostic-classification-following-the-treatment-of-developmental-dysplasia-of-the-hip
#17
Y Tsukagoshi, M Kamegaya, H Kamada, T Saisu, M Morita, J Kakizaki, Y Tomaru, M Yamazaki
AIMS: The aim of this study was to evaluate the correlation between Salter's criteria and Kalamchi's classification of avascular necrosis in patients treated for developmental dysphasia of the hip (DDH). PATIENTS AND METHODS: The study involved a retrospective analysis of 123 patients (123 hips) with DDH treated by operative and non-operative reduction before the age of two years, with a minimum follow-up of ten years. Salter's criteria (S1 to S4) were determined from radiographs obtained at one to two years post-reduction, whilst the Kalamchi grade was determined from radiographs obtained at ten or more years of age...
August 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28754159/the-role-of-electrical-stimulation-in-the-management-of-avascular-necrosis-of-the-femoral-head-in-adults-a-systematic-review
#18
Talal Al-Jabri, Jessica Yan Qi Tan, Gabriel Yihan Tong, Ravikiran Shenoy, Babar Kayani, Timothy Parratt, Tahir Khan
BACKGROUND: Avascular necrosis of the femoral head causes significant morbidity and occurs in up to 20,000 people per year. A variety of nonoperative and operative measures have been trialled however a definitive treatment algorithm is yet to be established. Young adults in many cases have undergone multiple surgical procedures in their lifetime with increasing risks of complications. Less invasive techniques may help reduce the number of operations required and positively influence the natural history of the disease process...
July 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28750788/autologous-platelet-concentrates-as-treatment-for-avascular-necrosis-of-femoral-head-in-a-dog
#19
Estefanía Parra, Andrea Vergara, Raúl F Silva
Avascular necrosis of the femoral head is a developmental disturbance that generally affects young dogs of small breeds and produces ischemic necrosis of the femoral head resulting in an incongruous and malformed joint. The most common treatment is the excisional arthroplasty of the head and femoral neck. The aim of this study is to describe the treatment of avascular necrosis in a Yorkshire dog using intra-articular injections of autologous platelet concentrate. Evaluations were made at 0, 15, 30, 60, and 120 days of treatment, describing the following parameters: clinical gait analysis, perimetry, goniometry, and radiographic evaluations...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28740529/legg-calv%C3%A3-perthes-disease-classifications-and-prognostic-factors
#20
REVIEW
Virginie Rampal, Jean-Luc Clément, Federico Solla
INTRODUCTION: Legg-Calvé-Perthes Disease (LCPD) represents idiopathic avascular necrosis of femoral head in pediatric population. Indications for treatment depend mostly on prognosis about femoral head sphericity and hip congruence at the end of growth. The aim of this review is to highline prognostic factors of LCPD. METHODS: Bibliographic search in PubMed allowed selection of 33 articles concerning prognostic factors and/or classification of LCPD. CONCLUSION: Clinical factors of poor prognosis are overweight, female sex, age exceeding 6 years old, and lack of hip abduction...
January 2017: Clinical Cases in Mineral and Bone Metabolism
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