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femoral head necrosis

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https://www.readbyqxmd.com/read/29750297/col2a1-mutation-c-3508g-a-leads-to-avascular-necrosis-of-the-femoral-head-in-a-chinese-family-a-case-report
#1
Fang Liu, Zhizheng Xiong, Qi Liu, Jinxi Hu, Wenhua Li, Na Zhang
Avascular necrosis of the femoral head (ANFH) is a consequence of ischemia. Although the majority of cases of ANFH are sporadic, certain familial cases of ANFH have been reported to be associated with collagen type II α1 chain (COL2A1) mutations, which lead to COL2A1 gene dysfunction. The structure of secreted type II collagen contains a core area with a triple helical glycine (Gly)‑X‑Y domain, and the replacement of Gly in this region as a result of COL2A1 mutations may damage the structure of type II collagen...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29750162/screening-of-serum-protein-markers-for-avascular-osteonecrosis-of-femoral-head-differentially-expressed-after-treatment-with-yuanshi-shengmai-chenggu-tablets
#2
Peng Deng, Jianchun Zeng, Jie Li, Wenjun Feng, Jinlun Chen, Yirong Zeng
Avascular necrosis of the femoral head (ANFH) is an a frequently occurring orthopaedic disease with high morbidity. Traditional Chinese Medicine (TCM) Yuanshi Shengmai Chenggu Tablet is a valid prescription for treating steroid-induced femoral head necrosis. However, there are rare investigations about the serum protein marker expression after the acting of drugs on hormone and TCM. In the present study, we aimed to systematically discover and validate the serum biomarkers expression difference in patients with steroid-induced avascular necrosis of femoral head (SANFH) after taking Yuanshi Shengmai Chenggu Tablets (SANFH-TCM), so as to reveal the action mechanism of TCM from the molecular level by using isobaric tags for relative and absolute quantification (iTRAQ) with multiple reaction monitoring quantification...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29744100/bilateral-fibular-hemimelia-associated-with-hip-dislocation-and-femoral-head-necrosis
#3
Salahiddine Saghir, Hicham Bousbaa, Aomar Agadr
We describe a case of association of congenital bone abnormalities. It will allow clinicians to look systematically for other skeletal malformations and teach them how to evaluate these cases for the first time. This early screening will enable appropriate treatment to avoid complications and to preserve functional prognosis.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29729342/safflower-carthamus-tinctorius-l-polysaccharide-attenuates-cellular-apoptosis-in-steroid-induced-avascular-necrosis-of-femoral-head-by-targeting-caspase-3-dependent-signaling-pathway
#4
Daping Cui, Dewei Zhao, Benjie Wang, Baoyi Liu, Lei Yang, Hui Xie, Zihua Wang, Liangliang Cheng, Xing Qiu, Zhijie Ma, Mingyang Yu, Di Wu, Hao Long
The present study aimed to investigate the effects of a purified polysaccharide (SPS) from the safflower in a cellular model of steroid-associated necrosis of the femoral head (SANFH), which was established in primary murine osteoblasts suffering dexamethasone pretreatment. After treatment with SPS (25, 50 and 100 μg/ml), the degree of necrosis induced by dexamethasone was significantly reduced in osteoblasts as evidenced by an increase of cell viability and a decrease of apoptosis in osteoblasts. Furthermore, pretreatment with SPS (25, 50 and 100 μg/ml) significantly attenuated the activation of caspase-3 and cleavage of PARP relative to the model control cells...
May 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29727407/three-dimensional-mri-analysis-of-femoral-head-remodeling-after-reduction-in-patients-with-developmental-dysplasia-of-the-hip
#5
Yuta Tsukagoshi, Hiroshi Kamada, Makoto Kamegaya, Ryoko Takeuchi, Shogo Nakagawa, Yohei Tomaru, Kenta Tanaka, Mio Onishi, Tomofumi Nishino, Masashi Yamazaki
BACKGROUND: Previous reports on patients with developmental dysplasia of the hip (DDH) showed that the prereduced femoral head was notably smaller and more nonspherical than the intact head, with growth failure observed at the proximal posteromedial area. We evaluated the shape of the femoral head cartilage in patients with DDH before and after reduction, with size and sphericity assessed using 3-dimensional (3D) magnetic resonance imaging (MRI). METHODS: We studied 10 patients with unilateral DDH (all female) who underwent closed reduction...
May 2, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29725783/stem-cell-therapy-for-osteonecrosis-of-the-femoral-head-current-trends-and-comprehensive-review
#6
REVIEW
Lei Zhao, Alan David Kaye, Aaron J Kaye, Alaa Abd-Elsayed
PURPOSE OF REVIEW: Osteonecrosis of the femoral head (ONFH) is a common and frequently occurring disease. It is caused by interruption of blood supply with different etiologies. ONFH leads to degeneration and necrosis of the subchondral bone of the femoral head and eventually collapse of the femoral head. ONFH has a high disability rate, seriously affecting the quality of living of patients, and often involves middle-aged and younger people. RECENT FINDINGS: In recent years, the technology and understanding of stem cells and regenerative medicine have been developing rapidly...
May 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29715363/hip-joint-contact-pressure-distribution-during-pavlik-harness-treatment-of-an-infant-hip-a-patient-specific-finite-element-model
#7
Behzad Vafaeian, Samer Adeeb, Marwan El-Rich, Dornoosh Zonoobi, Abhilash R Hareendranathan, Jacob L Jaremko
Developmental dysplasia of the hip (DDH) in infants under 6 months of age is typically treated by the Pavlik harness (PH). During successful PH treatment, a subluxed/dislocated hip is spontaneously reduced into the acetabulum, and DDH undergoes self-correction. PH treatment may fail due to avascular necrosis (AVN) of the femoral head. An improved understanding of mechanical factors accounting for the success/failure of PH treatment may arise from investigating articular cartilage contact pressure (CCP) within a hip during treatment...
July 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29698303/closed-reduction-osteotomy-and-fibular-graft-are-effective-in-treating-pediatric-femoral-neck-pseudarthrosis-after-infection
#8
Rajesh Kumar Kanojia, Sumit Gupta, Ajay Kumar, Bachha Kanakeya Reddy
BACKGROUND: When treatment of acute septic arthritis of the hip is delayed, severe sequelae can occur. This may take the form of coxa breva, vara, or valga. Pseudoarthrosis of the femoral neck is a rare complication with only a few studies to guide treatment. QUESTION/PURPOSES: In a small series of patients with pseudarthrosis of the femoral neck after acute septic arthritis, we wanted to determine (1) whether femoral neck union can be achieved using a variety of surgical approaches; (2) whether these patients satisfied criteria outlined by Hunka and Choi, defined as a stable hip, a flexion arc ≥ 70° and no fixed adduction or abduction contractures, fixed flexion deformity not more than 20°, pain relief, and restoration of activities of daily living after surgery; and (3) any treatment-related complications if observed...
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29691613/lesion-size-measurement-in-femoral-head-necrosis
#9
Marvin E Steinberg, Seong C Oh, Viviane Khoury, Jayaram K Udupa, David R Steinberg
BACKGROUND: Management of patients with early stages of osteonecrosis of the femoral head remains controversial. Uniform use of an effective method of evaluation and classification, including both stage and lesion size, would allow for comparison and would significantly improve treatment of patients. There is no consensus on how best to determine lesion size. The purpose of this study was to evaluate and compare accuracy and ease of use of different techniques for determining the size of femoral head lesions...
April 25, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29687874/effects-of-platelet-rich-plasma-on-angiogenesis-and-osteogenesis-associated-factors-in-rabbits-with-avascular-necrosis-of-the-femoral-head
#10
X-L Zhang, K-Q Shi, P-T Jia, L-H Jiang, Y-H Liu, X Chen, Z-Y Zhou, Y-X Li, L-S Wang
OBJECTIVE: Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues. The present study aimed to examine the effects of PRP on the recovery of avascular necrosis of the femoral head (ANFH), and to provide novel insights into the clinical treatment of this disease. MATERIALS AND METHODS: A total of 24 New Zealand white rabbits were randomly divided into the normal control group, ANFH model and PRP-treated groups (n =1 2 each)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29686621/pravastatin-protects-against-avascular-necrosis-of-femoral-head-via-autophagy
#11
Yun Liao, Ping Zhang, Bo Yuan, Ling Li, Shisan Bao
Autophagy serves as a stress response and may contribute to the pathogenesis of avascular necrosis of the femoral head induced by steroids. Statins promote angiogenesis and ameliorate endothelial functions through apoptosis inhibition and necrosis of endothelial progenitor cells, however the process used by statins to modulate autophagy in avascular necrosis of the femoral head remains unclear. This manuscript determines whether pravastatin protects against dexamethasone-induced avascular necrosis of the femoral head by activating endothelial progenitor cell autophagy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29681819/avascular-necrosis-of-bone-following-chemotherapy-in-cancer-patients-with-coagulopathy-report-of-two-cases
#12
Hui-Ching Hsu, Tzu-Yao Liao, Dave Wei-Chih Chen, Yu-Hsiang Juan, Chuang-Chi Liaw
We report 2 cases of patients with solid tumors and coagulopathy who experienced avascular necrosis (AVN) of the bone following chemotherapy. Both cases exhibited nontraumatic bilateral AVN of the femoral heads, and one also showed bilateral AVN of the humeral heads. One case had multiple thromboembolic complications, including pulmonary obstructive syndrome and paraneoplastic pain. The other showed multiple paraneoplastic syndromes, with hypercalcemia and thrombocytosis. Groin pain and claudication of the lower extremities developed and persisted...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29607863/total-hip-replacement-in-sickle-cell-disorder-a-preliminary-report-of-challenges-and-early-outcome-of-21-consecutive-patients
#13
A U Katchy, U E Anyaehie, C U Nwadinigwe, G O Eyichukwu
Objective: The aim of this study is to describe the pattern of presentation osteoarthritic patients with sickle cell disorder (SCD) in our environment, determine the implant sizes taking the peculiar nature of the pathology and our operating environment into consideration, highlight the challenges and technical difficulties encountered during the procedure, measure the functional outcome and observe complications of treatment, recommend ways of improving outcome. Patients and Methods: Between November 2008 and November 2012, 29 consecutive primary total hip replacements (THRs) were performed on 21 patients with avascular necrosis of the head of femur secondary to SCD...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29576650/histological-observation-of-the-retinacula-of-weitbrecht-and-its-clinical-significance-a-cadaveric-study
#14
Bang Dou, Jiong Mei, Zhiyuan Wang, Ming Ni, Guangyao Jia, Shiwei Liu
Background: The retinacular arteries provide major supply to the femoral head, their injuries may lead to the femoral head necrosis (FHN) in femoral neck fractures. Although the femoral neck fracture was seriously displaced in some patients, FHN did not occur, which suggests that the blood supply is not fully blocked. This study was aimed to find the association between the structure of the retinacula of Weitbrecht and the mechanism of protecting retinacular arteries from being injured...
March 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29575173/vascular-supply-of-the-femoral-head-in-sheep-implications-for-the-ovine-femoroacetabular-impingement-model
#15
Moritz Tannast, Nadja Wolfer, Michael K Ryan, Katja M Nuss, Brigitte von Rechenberg, Simon D Steppacher
Sheep hips have a natural non-spherical head similar to a cam-type deformity in human beings. By performing an intertrochanteric varus osteotomy, cam-type femoroacetabular impingement can be induced experimentally. In sheep, the aspherical portion is located superiorly-exactly matching the region where the superior retinacular vessels enter the femoral head-neck junction in human beings. In order to fully exploit the potential of this experimental FAI model, a safe osteochondroplasty of the superior asphericity would need to be done without the risk of avascular necrosis...
March 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29570157/femoral-head-wedge-resection-for-the-treatment-of-avascular-necrosis-of-the-femoral-head-after-pediatric-femoral-neck-fracture-a-case-report
#16
Ha Yong Kim, Yong Han Cha, Won Sik Choy, Sang Wook Jeung, Yeon Seung Min
This research focuses on femoral head wedge resection for the treatment of avascular necrosis (AVN) of the femoral head. A 9-year-old girl presented to the emergency room complaining of right hip pain that occurred after a pedestrian car accident. After 8 months of internal fixation using cannulated screws for Delbet-type 2 fracture of the femoral neck, AVN of the femoral head developed in the patient. Even though valgus-derotation-extension intertrochanteric osteotomy was performed for the treatment of AVN, it progressed further and femoral head wedge resection was performed to recover the femoral head sphericity...
May 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/29569139/bone-preserving-total-hip-arthroplasty-in-avascular-necrosis-of-the-hip-a-matched-pairs-analysis
#17
David Merschin, Richard Häne, Mersedeh Tohidnezhad, Thomas Pufe, Wolf Drescher
PURPOSE: Short-stem hip arthroplasty has the potential advantage of femoral bone stock preservation, especially in view of the expected revisions in the often relatively young patients. Despite short-stem hip prosthesis are increasingly used for total hip arthroplasty, there are no sufficient mid- and long-term results especially for patients with avascular femoral head osteonecrosis. The present study investigates mid-term functional results as well as the revision rate following implantation of a short-stem prosthesis...
March 22, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29564212/neglected-traumatic-hip-dislocation-influence-of-the-increased-intracapsular-pressure
#18
Elsayed Ibraheem Elsayed Massoud
AIM: To investigate that the increased intracapsular pressure, during the delay period, can interrupt the blood flow to the femoral head. METHODS: An observational retrospective study included a group of 17 patients with traumatic hip dislocation, their ages at time of injury averaged 26 (range from 3 to 70) years. Outcomes were assessed clinically and radiographically at a period averaged 11.5 (range from 4 to 20) years. RESULTS: Minor trauma caused dislocation in seven and severe trauma in ten patients...
March 18, 2018: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29562413/-a-therapeutic-effect-analysis-of-femur-first-principle-and-combined-anteversion-technique-during-total-hip-arthroplasty
#19
X Q Wang, C S Wu, S Sun, J Wang, W Li, W Zhang
Objective: To investigate the situation of hip dislocation with the application of "femur first" principle and "combined anteversion technique" during total hip arthroplasty. Methods: A retrospective analysis has been done on the clinical data about 104 patients(133 hips)who were diagnosed as hip disease and were treated with total hip arthroplasty by the doctors from the Department of Joint Orthorpaedics of Shandong Provincial Hospital Affiliated to Shandong University from June 2014 to June 2016, and all the prostheses applied in the operation were cementless ones...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29551919/variation-and-significance-of-serum-leptin-blood-lipid-level-adiponectin-no-and-tnf-%C3%AE-for-patients-with-non-traumatic-ischemic-necrosis-of-the-femoral-head
#20
Bing Xu, Qiong-Hua Hu, Bo Zhao, Zong-Ke Zhou
Objective: To investigate the changes of serum leptin, lipid levels, adiponectin, NO and TNF-α in patients withnon-traumatic ischemic necrosis of the femoral head of the femoral head and its meanings. Methods: A total of 80 patients with ischemic necrosis of the femoral head were selected from January 2015 to January 2016. And 30 healthy volunteers who took the same time were selected as the control group. Both subjects were given venous blood in the morning fasting...
December 2017: Saudi Journal of Biological Sciences
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