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femoral head necrosis

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https://www.readbyqxmd.com/read/29337456/-pediatrics-perthes-disease-current-knowledges-and-treatment
#1
Sophie Merckaert, Pierre-Yves Zambelli
Perthes's disease corresponds to an interruption of the vascularization of the epiphyseal nucleus of the femoral head followed by avascular necrosis. This necrosis weakens the bone and subchondral fractures associated with a deformation of the femoral head is seen. It is important not to miss an extrusion of the femoral head, which makes surgical treatment unavoidable. The loss of joint congruence causes functional limitations and represents an increased risk for early hip osteoarthritis. Non weight bearing limits the subchondral fractures, but requires an important adaptation from the patient and his entourage...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29286832/avascular-necrosis-of-the-femoral-head
#2
Roberto Seijas, Andrea Sallent, Eila Rivera, Oscar Ares
About 250000 patients are operated on annually for hip arthroplasty in the USA alone. Of this number, about 10% the cause of their osteoarthritis is the avascular necrosis of the femoral head. But the causes of necrosis are multiple and many of them are still unknown. That is why small advances in etiopathogenesis, diagnosis and treatment of different causes are very important in order to reduce the number of affected patients. It may seem that small changes, studies focused on the details of different diseases do not bring great changes to science, but it is these small changes that end up adding great evolutions in our knowledge...
December 29, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29286130/salidroside-inhibits-steroid-induced-avascular-necrosis-of-the-femoral-head-via-the-pi3k-akt-signaling-pathway-in%C3%A2-vitro-and-in%C3%A2-vivo-studies
#3
Xing-He Xue, Zhen-Hua Feng, Zhen-Xing Li, Xiao-Yun Pan
Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections and immunological diseases, however they may cause steroid‑induced avascular necrosis of the femoral head (SANFH). Salidroside (Sal) has demonstrated an anti‑apoptotic effect on neurocytes by activating the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway. In the present study, primary osteoblasts were used in vitro and in rats in vivo to determine the anti-apoptotic effect of Sal on SANFH...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29281187/review-on-hyperbaric-oxygen-treatment-in-femoral-head-necrosis
#4
Enrico Camporesi, Giuliano Vezzani, Vincenzo Zanon, Daniele Manelli, Garrett Enten, Silvia Quartesan, Gerardo Bosco
BACKGROUND: Femoral head necrosis (FHN) is a common invalidating disease with an unclear etiology and pathophysiology that affects middle-aged people. FHN may lead to joint collapse and require invasive treatments. Because of its clinical and socioeconomic significance, an early diagnosis, staging and appropriate treatment are required. Unfortunately, to date a unique algorithm for the treatment of FHN has not been defined. OBJECTIVE: In this report we summarize the Tenth European Consensus Conference on hyperbaric medicine (April 2016, France), during which experts from Europe revised the list of accepted indications for hyperbaric oxygen (HBO₂) treatment, including FHN...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29275617/-treatment-of-patients-with-different-degree-of-acute-respiratory-distress-syndrome-caused-by-inhalation-of-white-smoke
#5
F W Yang, H M Xin, J H Zhu, X Y Feng, X C Jiang, Z Y Gong, Y L Tong
Objective: To summarize the treatment experience of patients with different degree of acute respiratory distress syndrome (ARDS) caused by inhalation of white smoke from burning smoke bomb. Methods: A batch of 13 patients with different degree of ARDS caused by inhalation of white smoke from burning smoke bomb, including 2 patients complicated by pulmonary fibrosis at the late stage, were admitted to our unit in February 2016. Patients were divided into mild (9 cases), moderate (2 cases), and serious (2 cases) degree according to the ARDS Berlin diagnostic criteria...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29261271/managing-dislocations-of-the-hip-knee-and-ankle-in-the-emergency-department-digest
#6
Caylyne Arnold, Zane Fayos, David Bruner, Dylan Arnold, Nachi Gupta, Jeffrey Nusbaum
Dislocation of the major joints of the lower extremities--hip, knee, and ankle--can occur due to motor-vehicle crashes, falls, and sports injuries. Hip dislocations are the most common, and they require emergent management to prevent avascular necrosis of the femoral head. Knee dislocations are uncommon but potentially dangerous injuries that can result in amputation due to the potential for missed secondary injury, especially if they are reduced spontaneously. Isolated ankle dislocations are relatively rare, as most ankle dislocations involve an associated fracture...
December 20, 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29260700/-slipped-capital-femoral-epiphysis-is-diagnosed-too-late
#7
Anders Elneff Graversen, Niels Wisbech Pedersen, Roland Knudsen
Slipped capital femoral epiphysis (SCFE) is a serious orthopaedic hip disease in the adolescent population. It has a prevalence of 10.8 per 100.000 children and usually occurs in children 9-16 years of age. Despite focus on delay of the diagnosis, no improvements have been made. An adolescent complaining of stress-related pain in the hip, groin, thigh or knee should be suspected of having SCFE, until an X-ray has excluded this diagnosis. Delayed diagnosis may have serious consequences in terms of further displacement of the femoral head and risk of increased avascular necrosis...
December 11, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29247327/il-21-enhances-the-degradation-of-cartilage-through-the-jak-stat-signaling-pathway-during-osteonecrosis-of-femoral-head-cartilage
#8
Bin Chen, Yi Liu, Lei Cheng
This study aims to investigate the role of interleukin-21 (IL-21) in the mechanism of osteonecrosis of the femoral head. The serum content of IL-21 in patients with osteonecrosis of the femoral head (ONFH) and with femoral neck fracture (FNF) was examined by an enzyme-linked immunosorbent assay (ELISA). The cartilage specimens were stained with safranin-O. The expression of IL-21, tumor necrosis factor-α (TNF-α), cyclooxygenase (COX-2), a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), matrix metalloproteinase-13(MMP-13), and aggrecan in the cartilage was detected, by immunohistochemistry and western blot analysis...
December 15, 2017: Inflammation
https://www.readbyqxmd.com/read/29242788/obturator-dislocation-of-hip-with-ipsilateral-fracture-neck-femur-a-case-report
#9
Sumit Kumar Jain, Parit Aggarwal, Arun Yadav
Introduction: Traumatic dislocation of the hip with ipsilateral fracture neck femur is a rare injury because of the different mechanism of both these injuries. The management of such injuries is a challenge as the chances of nonunion and avascular necrosis of femoral head are very high with fixation methods. We report a case of obturator dislocation of the hip with ipsilateral fracture neck of the femur which was treated with uncemented total hip replacement. Case Report: A 32-year-old male sustained obturator dislocation with ipsilateral fracture neck femur following road traffic accident...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29228956/analysis-of-bearing-wear-whole-blood-and-synovial-fluid-metal-ion-concentrations-and-histopathological-findings-in-patients-with-failed-asr-hip-resurfacings
#10
Lari Lehtovirta, Aleksi Reito, Jyrki Parkkinen, Harry Hothi, Johann Henckel, Alister Hart, Antti Eskelinen
BACKGROUND: Adverse Reaction to Metal Debris (ARMD) is still a major reason for revision surgeries in patients with metal-on-metal (MoM) hip replacements. ARMD consists of a wide range of alterations in periprosthetic tissues, most important of which are metallosis, inflammation, pseudotumors and necrosis. Studies investigating histopathological findings and their association to implant wear or indirect measures of wear have yielded inconsistent results. Therefore, we aimed to investigate bearing surface wear volume, whole blood and synovial fluid metal ion concentrations, histopathological findings in periprosthetic tissues and their associations...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29228594/bone-strengthening-pill-bsp-promotes-bone-cell-and-chondrocyte-repair-and-the-clinical-and-experimental-study-of-bsp-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#11
Zheng Li, Lulin Wang, Jin Wei, Liguo Zhu, Xisheng Weng, Jin Jin, Hong Xiao, Jun Zhang, Heming Wang, Guantong Shi, Lingpeng Pei, Fangde Zou, Wanqiang Zhang, Tianzun Tao, Xin Dong
About 1 in 3 people suffer from bone and joint disease, which is a disease of bone and cartilage cells. Osteonecrosis of the femoral head (ONFH) is a typical example of bone and joint disease involving bone cell necrosis. Osteonecrosis of the femoral head leads to the occurrence of premature osteoarthritis of the hip and collapse of the cartilage cells, and there is currently no effective drug treatment available. In order to study the effects of "bone-strengthening pill" (BSP) on the repair of bone and cartilage cells, we investigated the potential effects of the herbal mixture BSP in an animal model of avascular necrosis of the femoral head and in patients...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208853/investigations-of-cartilage-matrix-degeneration-in-patients-with-early-stage-femoral-head-necrosis
#12
Ronghua Xu, Bo Wei, Jiayi Li, Chenyu Huang, Rongcai Lin, Cheng Tang, Yan Xu, Qingqiang Yao, Liming Wang
BACKGROUND The purpose of this study was to explore changes in cartilage matrix in early-stage femoral head necrosis (FHN). MATERIAL AND METHODS Femoral head samples of patients with early FHN were collected during total hip arthroplasty (THA), high-field 7.0T MRI scans were performed in vitro, and the average T2 values were calculated. Cartilage samples were obtained from the weight-bearing area (FHN group) and non-weight-bearing area (Control group), divided into 3 equal parts and used for biochemical analysis, histopathological staining, and gene expression analysis...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29207081/increased-serum-protein-levels-by-yuanshi-shengmai-chenggu-tablet-in-treatment-of-avascular-osteonecrosis-of-the-femoral-head
#13
Jianchun Zeng, Peng Deng, Jie Li, Wenjun Feng, Jinlun Chen, Yirong Zeng
The traditional Chinese medicine (TCM) Yuanshi Shengmai Chenggu Tablet is used for treating the common orthopedic disease, hormone‑induced avascular necrosis of the femoral head (ANFH) in China. However, its underlying mechanism and the changes induced in the treatment of ANFH remain to be fully elucidated. In the present study, through the use of isobaric Tag for Relative and Absolute Quantitation and multiple reaction monitoring quantifications, corticosteroid‑induced femoral head necrosis and the effects of treatment with Yuanshi Shengmai Chenggu Tablet were examined...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203431/surgical-reduction-of-congenital-hip-dislocation
#14
REVIEW
C Glorion
Surgical reduction of congenital hip dislocation is technically challenging. In our practice, surgical reduction is usually reserved for patients who have failed non-operative treatment, which is the first-line strategy. However, primary surgery may be indicated if the dislocation is diagnosed late and can be performed until 8 years of age. The reduction step is crucial. It starts with painstaking exposure of the capsule. Identifying the lower part of the acetabulum is the key to accurate repositioning of the epiphysis...
December 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29198718/quadratus-femoris-muscle-pedicle-bone-flap-transplantation-in-the-treatment-of-femoral-neck-fracture-for-chinese-young-and-middle-aged-patients-a-systematic-review-and-meta-analysis
#15
Xiao-Jian Wang, Zhi-Hua Zhang, Lu Li, Yun-Xing Su, Lei Wei
PURPOSE: To compare the efficacy of quadratus femoris muscle pedicle bone flap transplantation combined with hollow compression screw fixation versus AO hollow compression screw fixation in the treatment of femoral neck fracture for Chinese young and middle-aged patients. METHODS: Case-controlled studies (CCTs) were used to compare the two operative methods in the treatment of femoral neck fractures. Data were retrieved from the Cochrane Library, Pubmed Database, CNKI, Chinese Biomedical Database...
November 4, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29192936/outcomes-of-femoral-head-marrow-stimulation-techniques-at-minimum-2-year-follow-up
#16
David E Hartigan, Itay Perets, Edwin O Chaharbakhshi, John P Walsh, Leslie C Yuen, Benjamin G Domb
This study compared patients who underwent femoral head microfracture with a control group of patients who did not require microfracture. Patients had more than 2 years of follow-up. The patient groups had similar demographic and radiographic features, including sex, age within 5 years, body mass index within 5 points, equal Tönnis grade, lateral center edge angle within 5°, labral treatment, and capsular closure vs release. Inclusion criteria were a minimum of 2 years of follow-up, Outerbridge grade IV cartilage damage, and femoral head marrow stimulation technique performed at the time of arthroscopy...
November 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/29185671/managing-dislocations-of-the-hip-knee-and-ankle-in-the-emergency-department
#17
Caylyne Arnold, Zane Fayos, David Bruner, Dylan Arnold
Dislocation of the major joints of the lower extremities--hip, knee, and ankle--can occur due to motor-vehicle crashes, falls, and sports injuries. Hip dislocations are the most common, and they require emergent management to prevent avascular necrosis of the femoral head. Knee dislocations are uncommon but potentially dangerous injuries that can result in amputation due to the potential for missed secondary injury, especially if they are reduced spontaneously. Isolated ankle dislocations are relatively rare, as most ankle dislocations involve an associated fracture...
December 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29181581/evaluation-of-femoral-head-viability-via-bone-scintigraphy-in-the-postoperative-pediatric-patient
#18
Ashishkumar K Parikh, Eleby R Washington, Adam J Bobbey, Stephanie E Spottswood
BACKGROUND: Evaluating postoperative patients with hardware is challenging following surgical intervention for hip maladies such as femoral neck fractures and slipped capital femoral epiphysis (SCFE). These children are at increased risk of developing avascular necrosis, and imaging may be requested to confirm or exclude this diagnosis. Children with Legg-Calvé-Perthes disease can be monitored for restoration of blood flow to the capital femoral epiphysis to guide management and help with prognosis...
November 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29181188/intra-articular-osteochondroma-of-the-posteroinferior-femoral-neck-associated-with-hip-joint-osteochondromatosis-a-case-report
#19
Sung Il Wang, Eun Hae Park, Sun Jung Yoon, Jung Ryul Kim
Osteochondromas are usually extra-articular lesions originating from the metaphysis of long bones. Intra-articular osteochondromas may also occur, causing pain and discomfort and restricting the range of motion. Osteochondromas of the femoral neck are intra-articular lesions that are difficult to access for surgical resection, particularly when located posteriorly. We herein present a rare case of an intra-articular osteochondroma involving the posteroinferior aspect of the femoral neck associated with secondary synovial osteochondromatosis (SOC) of the hip joint in a 25-year-old woman...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29167942/prognostic-analysis-of-different-morphology-of-the-necrotic-viable-interface-in-osteonecrosis-of-the-femoral-head
#20
Wei Wu, Wei He, Qiu-Shi Wei, Zhen-Qiu Chen, Da-Wei Gao, Peng Chen, Qing-Wen Zhang, Bin Fang, Lei-Lei Chen, Bao-Ling Li
PURPOSE: The purpose of this study was to investigate the collapse progression in different morphologies of the necrotic-viable interface in osteonecrosis of the femoral head (ONFH). METHODS: A total of 168 patients (202 hips) with Association Research Circulation Osseous (ARCO) stage II ONFH were included. Ending with the collapse of the femoral head, all patients received conservative treatment but without surgical intervention and were followed for three to 91 months...
November 22, 2017: International Orthopaedics
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