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osteonecrosis gene

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https://www.readbyqxmd.com/read/28009825/neuropeptide-y1-receptor-regulates-glucocorticoid-induced-inhibition-of-osteoblast-differentiation-in-murine-mc3t3-e1-cells-via-erk-signaling
#1
Wei Yu, Chao Zhu, Wenning Xu, Leisheng Jiang, Shengdan Jiang
High dose glucocorticoid (GC) administration impairs the viability and function of osteoblasts, thus causing osteoporosis and osteonecrosis. Neuropeptide Y1 receptor (Y1 receptor) is expressed in bone tissues and cells, and regulates bone remodeling. However, the role of Y1 receptor in glucocorticoid-induced inhibition of osteoblast differentiation remains unknown. In the present study, osteoblastic cell line MC3T3-E1 cultured in osteogenic differentiation medium was treated with or without of 10(-7) M dexamethasone (Dex), Y1 receptor shRNA interference, Y1 receptor agonist [Leu(31), Pro(34)]-NPY, and antagonist BIBP3226...
December 21, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28000841/genome-wide-association-scans-for-idiopathic-osteonecrosis-of-the-femoral-head-in-a-korean-population
#2
Seung-Hoon Baek, Kang-Il Kim, Kyung-Sik Yoon, Tae-Ho Kim, Shin-Yoon Kim
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease and is associated with genetic predisposition, and exposure to certain risk factors. In particular, idiopathic ONFH in twins and the clustering of cases in families have indicated that genetic factors are involved. However, the majority of cases of ONFH are sporadic and various studies have demonstrated that differences in the study design and/or the ethnic groups analyzed leads to different results. The present study performed one of the first genome‑wide association studies to identify genetic loci that may increase the risk of idiopathic ONFH...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28000662/hematopoietic-stem-cells-in-neural-crest-derived-bone-marrow
#3
Nan Jiang, Mo Chen, Guodong Yang, Lusai Xiang, Ling He, Thomas K Hei, Gregory Chotkowski, Dennis P Tarnow, Myron Finkel, Lei Ding, Yanheng Zhou, Jeremy J Mao
Hematopoietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensively studied. Neural crest-derived bones differ from appendicular bones in developmental origin, mode of bone formation and pathological bone resorption. Whether neural crest-derived bones harbor HSCs is elusive. Here, we discovered HSC-like cells in postnatal murine mandible, and benchmarked them with donor-matched, mesoderm-derived femur/tibia HSCs, including clonogenic assay and long-term culture. Mandibular CD34 negative, LSK cells proliferated similarly to appendicular HSCs, and differentiated into all hematopoietic lineages...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27994198/osteoprotegerin-polymorphisms-are-associated-with-alcohol-induced-osteonecrosis-of-femoral-head-in-chinese-han-population-from-henan-province
#4
Yizhou Li, Yongchang Guo, Quanjian Wang, Yongri Ouyang, Yuju Cao, Tianbo Jin, Jianzhong Wang
Alcohol-induced osteonecrosis of femoral head (ONFH) is one of the most important pathogenesis of nontraumatic ONFH. However, its pathogenesis mechanism is still unknown. Osteoprotegerin (OPG) has been implicated in multiple functions including blocking osteoclast maturation, controlling vascular calcifications, promoting tumour growth and metastasis. This study is focussed on OPG gene polymorphisms associated with alcohol-induced ONFH. A total of 509 participants (209 patients and 300 normal individuals) were recruited, and we selected 13 single-nucleotide polymorphisms (SNPs) to evaluate the association between genetic susceptibility variants and alcohol-induced ONFH by using the χ(2) test and genetic model analysis...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27957785/a-thymidylate-synthase-polymorphism-is-associated-with-increased-risk-for-bone-toxicity-among-children-treated-for-acute-lymphoblastic-leukemia
#5
Yaron Finkelstein, Traci M Blonquist, Veena Vijayanathan, Kristen E Stevenson, Donna S Neuberg, Lewis B Silverman, Lynda M Vrooman, Stephen E Sallan, Peter D Cole
BACKGROUND: Bone fractures and osteonecrosis frequently complicate therapy for childhood acute lymphoblastic leukemia (ALL). Bone toxicity has been associated with exposure to corticosteroids and methotrexate (MTX) and age greater than 10 years. We tested whether common genetic polymorphisms were associated with bone toxicity during treatment for ALL. PROCEDURE: A total of 615 of 794 children enrolled on Dana Farber Cancer Institute ALL Consortium protocol 05-001 (NCT00400946) met eligibility criteria for inclusion in this analysis...
December 13, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27930516/single-nucleotide-polymorphisms-of-mmp2-in-mmp-timp-pathways-associated-with-the-risk-of-alcohol-induced-osteonecrosis-of-the-femoral-head-in-chinese-males-a-case-control-study
#6
Yan Yu, Zhilan Xie, Jihan Wang, Chu Chen, Shuli Du, Peng Chen, Bin Li, Tianbo Jin, Heping Zhao
The proportion of alcohol-induced osteonecrosis of the femoral head (ONFH) in all ONFH patients was 30.7%, with males prevailing among the ONFH patients in mainland China (70.1%). Matrix metalloproteinase 2 (MMP2), a member of the MMP gene family, encodes the enzyme MMP2, which can promote osteoclast migration, attachment, and bone matrix degradation. In this case-control study, we aimed to investigate the association between MMP2 and the alcohol-induced ONFH in Chinese males.In total, 299 patients with alcohol-induced ONFH and 396 healthy controls were recruited for a case-control association study...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27924611/quantitative-real-time-gene-profiling-of-human-alveolar-osteoblasts
#7
Dawn E Coates, Sobia Zafar, Trudy J Milne
The use of quantitative real-time reverse transcriptase PCR (qRT(2)-PCR) for the identification of differentially regulated genes is a powerful technology. The protocol presented here uses qRT(2)-PCR gene arrays to investigate the regulation of 84 angiogenic related genes in human primary alveolar osteoblasts following treatment with the bisphosphonate, zoledronic acid (ZA), and geranylgeraniol (GGOH). GGOH has potential as a therapeutic agent for Bisphosphate-Related Osteonecrosis of the Jaw (BRONJ), a serious side-effect resulting from the treatment for metastatic cancer (Zafar et al...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27869039/the-role-of-rs1984112_g-at-cd36-gene-in-increasing-reticulocyte-level-among-sickle-cell-disease-patients
#8
Miniar Kalai, Marwa Dridi, Leila Chaouch, Imen Moumni, Houyem Ouragini, Imen Darragi, Imen Boudrigua, Dorra Chaouachi, Fethi Mellouli, Mohamed Bejaoui, Salem Abbes
AIMS AND BACKGROUND: Mediators of adhesion become a potential new target for pharmacological therapy to struggle the complications of sickle cell disease (SCD). Several mechanisms for increased adherence have been postulated and the well-studied are CD36 and VLA4 which encoded by ITGA4. Herein, we sought to determine whether one polymorphism of CD36 namely: rs1984112 and three exons of ITGA4 (4, 5, and 6) are implicated in hemolytic status and clinical events among SCD Tunisian patients...
November 20, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27858915/genetic-polymorphisms-of-cyp3a4-among-chinese-patients-with-steroid-induced-osteonecrosis-of-the-femoral-head
#9
Yuan Wang, Xiuling Li, Yaoyu Gao, Zhi Li, Lidong Yu, Qingbo Meng, Li Sun, Jianzhong Wang
BACKGROUND: Steroid therapy has been an important reason of nontraumatic osteonecrosis of the femoral head (ONFH). Steroids are metabolized by hepatic cytochrome P4503A, a low endogenous activity of this enzyme can contribute to the pathogenesis of ONFH. The aim of this study was to investigate the associations of polymorphisms of cytochrome P4503A4 (CYP3A4) gene with steroid-induced ONFH in Chinese patients. METHODS: A total of 150 steroid-induced ONFH patients and 250 healthy controls were enrolled...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27818895/magnesium-alloy-transfected-bmscs-bmp-2-composite-in-repair-of-femoral-head-necrosis-with-assessment-of-visceral-organs
#10
Kaka A A Katiella, Zhang Yanru, Zhang Hui
BACKGROUND: This study was designed to investigate the effect of BMSCs transfected BMP-2 composite with magnesium alloy rod in the repair of the femoral head necrosis in New Zealand white rabbits. Multifactorial but mostly traumatic, osteonecrosis of the femoral head account for 10 % of the 250,000 total hip arthroplasties done annually in the United States while its prevalence in most countries in not known. However, early intervention prior to collapse is critical to successful outcomes in joint preserving procedures...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27704894/associations-of-igfbp3-gene-polymorphism-and-gene-expression-with-the-risk-of-osteonecrosis-of-the-femoral-head-in-a-han-population-in-northern-china
#11
Yang Song, Zhenwu Du, Qiwei Yang, Ming Ren, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Jincheng Wang, Guizhen Zhang
The critical roles of IGFBP3 in regulating the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells strongly indicate its potential effects on the pathogenesis of osteonecrosis of the femoral head (ONFH). In this study, we investigated the association of IGFBP3 gene polymorphism and its protein expression with the development of ONFH to further explore its molecular pathogenesis. Ligase detection reactions and enzyme-linked immunosorbent assay were used to detect the polymorphisms of rs2453839[C/T] and rs3110697[A/G] and the serum protein expression of IGFBP3 gene in 182 cases and 179 controls, respectively...
December 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27648614/necrotic-bone-stimulates-proinflammatory-responses-in-macrophages-through-the-activation-of-toll-like-receptor-4
#12
Naga Suresh Adapala, Ryosuke Yamaguchi, Matthew Phipps, Olumide Aruwajoye, Harry K W Kim
In Legg-Calvé-Perthes disease, loss of blood supply results in ischemic osteonecrosis of the femoral head (ONFH). Generally, macrophages play important roles in inflammatory responses to tissue necrosis, but their role in ONFH is not known. The purpose of this study was to determine the macrophage-inflammatory responses after ONFH and the receptor mechanisms involved in sensing the necrotic bone, using a piglet model of Legg-Calvé-Perthes disease. Induction of ONFH resulted in increased numbers of CD14(+) macrophages in the fibrovascular repair tissue compared with normal, as determined by immunohistochemistry...
November 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27637086/a-single-nucleotide-polymorphism-in-mmp9-is-associated-with-decreased-risk-of-steroid-induced-osteonecrosis-of-the-femoral-head
#13
Jieli Du, Wanlin Liu, Tianbo Jin, Zhenqun Zhao, Rui Bai, Huiqin Xue, Junyu Chen, Mingqi Sun, Xiyang Zhang, Guoqiang Wang, Jianzhong Wang
Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27631232/association-between-genetic-polymorphisms-of-mmp8-and-the-risk-of-steroid-induced-osteonecrosis-of-the-femoral-head-in-the-population-of-northern-china
#14
Jieli Du, Tianbo Jin, Yuju Cao, Junyu Chen, Yongchang Guo, Mingqi Sun, Jian Li, Xiyang Zhang, Guoqiang Wang, Jianzhong Wang
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (ONFH) is the most common clinical nontraumatic ONFH. Once ONFH occurs, it seriously reduces patients' quality of life. The matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP) system was found to play a significant role in the development of ONFH. The aim of this study was to identify the associations between 7 genes selected from the MMP/TIMP system and steroid-induced ONFH. METHODS: We genotyped 34 single-nucleotide polymorphisms (SNPs) of 7 genes selected from the MMP/TIMP system in a case-control study with 285 cases of steroid-induced ONFH and 308 healthy controls...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27627619/tet3-mediates-alterations-in-the-epigenetic-marker-5hmc-and-akt-pathway-in-steroid-associated-osteonecrosis
#15
Jie Zhao, Xin-Long Ma, Jian-Xiong Ma, Lei Sun, Bin Lu, Ying Wang, Guo-Sheng Xing, Yan Wang, Ben-Chao Dong, Li-Yan Xu, Ming-Jie Kuang, Lin Fu, Hao-Hao Bai, Yue Ma, Wei-Lin Jin
Steroid-associated osteonecrosis (SAON) is one of the common complications of clinical glucocorticoid (GC) administration, with osteocyte apoptosis appearing as the primary histopathological lesion. However, the precise mechanism underlying SAON remains unknown. Epigenetic modification may be a major cause of SAON. Recently, cumulative research revealed that Ten-Eleven Translocation (TET) proteins can catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and then alter the epigenetic state of DNA...
September 13, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27446959/association-of-complement-receptor-2-gene-polymorphisms-with-susceptibility-to-osteonecrosis-of-the-femoral-head-in-systemic-lupus-erythematosus
#16
Tae-Ho Kim, Sang-Cheol Bae, Sang-Han Lee, Shin-Yoon Kim, Seung-Hoon Baek
Osteonecrosis of the femoral head (ONFH) is a complex and multifactorial disease that is influenced by a number of genetic factors in addition to environmental factors. Some autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), are associated with the development of ONFH. Complement receptor type 2 (CR2) is membrane glycoprotein which binds C3 degradation products generated during complement activation. CR2 has many important functions in normal immunity and is assumed to play a role in the development of autoimmune disease...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27446285/risk-factors-for-symptomatic-osteonecrosis-in-childhood-all-a-retrospective-study-of-a-slovenian-pediatric-all-population-between-1970-and-2004
#17
Nataša Karas-Kuželički, Simona Mencej-Bedrač, Janez Jazbec, Janja Marc, Irena Mlinarič-Raščan
Treatment induced non-traumatic osteonecrosis (ON) has been reported increasingly in children treated for acute lymphoblastic leukemia (ALL). Several risk factors for ON have been identified in childhood cancer patients; however, their diagnostic and prognostic power is limited and the etiology of the disease remains unclear. Therefore, a continuous effort is focused on the identification of additional ON risk factors. We performed a retrospective study of 313 childhood ALL patients to test the association between the ON occurrence in children receiving ALL therapy and common polymorphisms in potential target genes: Thiopurine S-methyltransferase (TPMT; 460G>A, 719A>G), 5,10-methylenetetrahydrofolate reductase (MTHFR; 677C>T, 1298A>C), estrogen receptor alpha 1 (ESR1; XbaI) and collagen type I, α1 (COL1A1; Sp1)...
August 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27396977/p-glycoprotein-overexpression-in-bone-marrow-derived-multipotent-stromal-cells-decreases-the-risk-of-steroid-induced-osteonecrosis-in-the-femoral-head
#18
Ning Han, Zengchun Li, Zhengdong Cai, Zuoqin Yan, Yingqi Hua, Chong Xu
P-glycoprotein (P-gp) plays a role in steroid-induced osteonecrosis of the femoral head (ONFH), but the underlying mechanism remains unknown. We hypothesized that P-gp overexpression can prevent ONFH by regulating bone marrow-derived multipotent stromal cell (BMSC) adipogenesis and osteogenesis. BMSCs from Sprague-Dawley rats were transfected with green fluorescent protein (GFP) or the multidrug resistance gene 1 (MDR1) encoding GFP and P-gp. Dexamethasone was used to induce BMSC differentiation. Adipogenesis was determined by measuring peroxisome proliferator-activated receptor (PPAR-γ) expression and the triglyceride level...
July 11, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27385686/hif-1-dependent-il-6-activation-in-articular-chondrocytes-initiating-synovitis-in-femoral-head-ischemic-osteonecrosis
#19
Ryosuke Yamaguchi, Nobuhiro Kamiya, Naga Suresh Adapala, Hicham Drissi, Harry K W Kim
BACKGROUND: Ischemic osteonecrosis of the femoral head in children is associated with chronic hip synovitis and increased levels of the pro-inflammatory cytokine interleukin-6 (IL-6) in the synovial fluid due to unknown mechanisms. The purpose of this study was to investigate hypoxia-inducible factor-1 (HIF-1) activation as a molecular mechanism linking the induction of ischemic osteonecrosis to IL-6 production and the initiation of hip synovitis. METHODS: Ischemic osteonecrosis was surgically induced in the right femoral head of 6 piglets...
July 6, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27378744/differential-expression-of-mir-672-5p-and-mir-146a-5p-in-osteoblasts-in-rats-after-steroid-intervention
#20
Pengfei Li, Nan Sun, Jianchun Zeng, Yirong Zeng, Yueguang Fan, Wenjun Feng, Jie Li
BACKGROUND: Apoptosis of osteoblasts and osteocytes is one cause of steroid-induced osteonecrosis of the femoral head; however, the molecular mechanism of steroid affecting osteoblasts at the genetic level is unclear. The aim of the present work is to examine differential expression of osteoblasts in rats after steroid intervention and to verify expression by real-time polymerase chain reaction (RT-PCR). METHODS: Primary culture, passaging and identification of osteoblasts of SD neonatal rats were conducted; osteoblasts were divided into two groups, the control group, and the steroid group...
October 10, 2016: Gene
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