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I I Dedov, D G Kurbatov, R V Rozhivanov, A E Lepetukhin, S A Dubskiĭ, N P Goncharov
The article presents original experience with use of undecanoate (nebido, BayerHealthcare Pharmaceuticals, Germany) in androgenic testosteron replacement therapy in males with hypogonadism. Prospective studies of nebido efficacy were made in males with vein-occlusive erectile dysfunction (n = 20), chronic pelvic pain syndrome (n = 77), metabolic syndrome (n = 170). Retrospective studies assessed efficacy of nebido monotherapy in patients with erectile dysfunction and hypogonadism (n = 34), hematological and urological safety of the drug (n = 40)...
November 2011: Urologii︠a︡
Odery Ramos, César Luiz Boguszewski, Sandra Teixeira, Ricardo De Bem, Benito Parolim, João Carlos Prolla
CONTEXT: Acromegalic patients have better chances to develop colorectal polyps and cancer and, considered a high-risk group, need to undergo frequent screening examinations. Moreover, in acromegalia, the increased bowel length and the intestinal loop complexity can lead to higher levels of technical difficulties and increase the risks of complications at conventional colonoscopy. Computed tomographic colonography, also known as virtual colonoscopy, is an innovative and secure technology which is revolutionizing the diagnosis of colon and rectum neoplasias...
April 2009: Arquivos de Gastroenterologia
Julio Brito, Lya Sáez, Melchor Lemp, Claudio Liberman, Harold Michelsen, A Verónica Araya
BACKGROUND: Growth hormone (GH) producing adenomas, frequently express several hormones. This condition could confer them a higher proliferative capacity. Ki-67 is a nuclear protein antigen that is a marker for proliferative activity. AIM: To measure the immunohistochemical hormone expression in pituitary adenomas, excised from patients with acromegaly. To determine if the plurihormonal condition of these adenomas is associated with a higher proliferative capacity, assessed through the expression of Ki-67...
July 2008: Revista Médica de Chile
No abstract text is available yet for this article.
1949: Ceskoslovenská Gynekologie
Antonio Mestron, Susan M Webb, Ricardo Astorga, Pedro Benito, Miguel Catala, Sonia Gaztambide, Jose-Manuel Gomez, Irene Halperin, Tomas Lucas-Morante, Basilio Moreno, Gabriel Obiols, Pedro de Pablos, Concha Paramo, Antonio Pico, Elena Torres, Cesar Varela, Jose-Antonio Vazquez, Juana Zamora, Merce Albareda, Montserrat Gilabert
OBJECTIVE: To undertake a multicentre epidemiological study reflecting acromegaly in Spain. DESIGN: Voluntary reporting of data on patients with acromegaly to an online database, by the managing physician. METHODS: Data on demographics, diagnosis, estimated date of initial symptoms and diagnosis, pituitary imaging, visual fields, GH and IGF-I concentrations (requested locally), medical, radiotherapy and neurosurgical treatments, morbidity and mortality were collected...
October 2004: European Journal of Endocrinology
No abstract text is available yet for this article.
May 18, 1952: Orvosi Hetilap
A Bennet
Hypertrichosis, characterized by increased hair growth located in non-androgen-dependent areas, does not justify the monitoring of hormone levels, conversely to hirsutism, with increased hair growth in androgen-dependent areas of the female genitals. Adult hypertrichosis is iatrogenic (minoxidil, ciclosporine, diazoxide or glucocorticosteroids), of metabolic origin (porphyria), nutritional (anorexia) or paraneoplastic (hypertrichosis lanuoginosa). Metabolic or general assessment can help clinical diagnosis...
May 2002: Annales de Dermatologie et de Vénéréologie
P Morillas, A Frutos, V Bertomeu, R Valero, J A Rodríguez, V Climent, M Moragón
The Carney complex is an autosomal dominant syndrome characterised by multiple neoplasies, including myxomas at various sites (cardiac, cutaneous, mammary), spotty pigmentation, endocrine overactivity (Cushing's syndrome, acromegalia), testicular tumours and schwannomas. This report describes the case of a 43-year-old woman with an acute inferior myocardial infarction, probably due to coronary embolization from a large left atrial myxoma and who presented this association. A brief review of the Carney complex is provided after discussion of this rare case that required an screening of family members...
June 2001: Revista Española de Cardiología
T B Hansen, J Gram, P B Jensen, J H Kristiansen, B Ekelund, J S Christiansen, F B Pedersen
BACKGROUND: Many adult patients in chronic hemodialysis exhibit malnourishment and muscle wasting, which in some may be due partly to blockage of the biological action of growth hormone and the somatomedines. Growth hormone (GH) promotes protein synthesis, and long-term treatment with growth hormone has induced an augmentation in lean body-mass (LBM) in normal elderly persons, in persons with GH deficiency as well as growth improvement in uremic children. The purpose of this study was to evaluate the effect of long-term GH treatment on soft tissues in hemodialyzed patients by dual-energy X-ray absorptiometry (DXA) with special regard to the improvement in lean body mass and fat mass (FM)...
February 2000: Clinical Nephrology
F Grunenberger, J L Schliengen, T Vogel, D Orenstein, D Maitrot, A Ruellan
Pituitary stimulation tests are widely used to explore hypophyseal adenomas. There are few disadvantages, although a few cases of pituitary necrosis have been published. We report a new case with a dramatic outcome. A 30-year-old man with clinical signs of acromegalia and major visual disorders was found to have a voluminous macro-adenoma of the pituitary gland. Thirty minutes after beginning the stimulation test, the patient complained of major headache and experienced persistant vomiting for several hours...
November 2, 1996: La Presse Médicale
P Becker, D Schachter, E Gallardo, E Colin, J Selman, C Martínez
The clinical manifestations and the surgical treatment results of 280 patients (179 female), undergoing a total of 319 operations at the Asenjo Institute of Neurosurgery were retrospectively analyzed. The surgical approach for the first operation was transphenoidal in 89.3% of patients and transcraneal in the rest. Tumors were non-secretory in 169 (60.4%) patients, prolactinomas in 75 (27.8%) and produced acromegalia in 29 (10.4%) and Cushing syndrome in 7 (2.5%) patients. There was extraselar extension in 42% of women and 71% of men...
July 1994: Revista Médica de Chile
L E Afzelius, D Elmqvist, S Laurin, A M Risberg, M Aberg
Obstructive sleep apnea syndrome was every likely caused by an enlarged tongue in a 60-year-old man with acromegalia. The diagnosis was confirmed by polygraphic sleep recordings and by roentgenologic examination. The patient was treated with a tongue-reduction plasty which gave him good subjective relief and better sleep. A whole night polygraphic sleep recording showed a couple of hours of normal sleep without apneas or arousals. The last part of the night was, however, still disturbed by several apneas with concomitant arousals...
1982: ORL; Journal for Oto-rhino-laryngology and its related Specialties
A S Efimov, Iu V Bezdrobnyĭ, N Iu Evdokimova, I V Komissarenko, N P Demchenko
Insulin receptors from fatty cell cytoplasmatic membranes were studied in 8 patients with acromegalia, who did not exhibit distinct impairments in carbohydrate metabolism. Concentration of insulin receptors was decreased 1.5-fold in the patients as compared with healthy people. However, affinity of free and blocked receptors to insulin as well as the degree of negative cooperativity between them were not distinctly altered.
September 1981: Voprosy Medit︠s︡inskoĭ Khimii
G A Kuchaeva
Clinical observations of 90 patients suffering from syringomyelia revealed growth defects frequent with this pathology, such as, short height, acromegalia, macrosomia, cheiromegalia, costal hump. Hormonal examinations with determination of the growth hormone content in the blood carried out by functional tests confirmed the frequently observed disturbance of the somatotropic function of the hypophysis in syringomegalic patients. The leading role of the change of the hypothalamus functional state and the disturbance of the hypothalamohypophysial interrelations were revealed...
1980: Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova
V Severineanu, G Lungu, R Lungu
No abstract text is available yet for this article.
July 1984: Revista de Chirurgie, Oncologie, Radiologie, O. R. L., Oftalmologie, Stomatologie. Seria: Stomatologie
(no author information available yet)
No abstract text is available yet for this article.
1971: L'Année Endocrinologique
(no author information available yet)
No abstract text is available yet for this article.
September 1971: Revue de Stomatologie et de Chirurgie Maxillo-faciale
S Holck, U M Wewer, R Albrechtsen
Thirty-eight human pituitary adenomas (24 endocrine active and 14 endocrine inactive tumors) were studied immunohistochemically for the presence of the basement membrane component, laminin, and ultrastructurally for the presence of basement membrane. Immunoreactivity of laminin delineated staining of epithelial and endothelial basement membranes, the reaction product being confined mostly to the perivascular zones. Moreover, a hitherto undescribed presence of intercellular laminin-positive droplets was observed in ten of the active adenomas (nine patients with hyperprolactinemia and/or acromegalia and one patient with Cushing's syndrome)...
1986: Acta Neuropathologica
A Bazex, C Boulard, G Delsol, J Bazex, J L Louvet
This entity, isolated by Gorlin, is characterized by the presence of cutaneous and mucous neuromas, facial disfiguration resembling acromegalia as well as morphological changes to the extremities similar to those produced by Marfan's disease. These factors are also associated with multiple endocrinological neoplasms type II of Sipple's syndrome. In other words, malignant tumors developing from thyroid "C" cells as well as from bilateral benign pheochromocytoma (neoplasias which derive from the A.P.U.D. system)...
February 1977: Annales de Dermatologie et de Vénéréologie
J Sany, F Rosenberg, R Bataille, H Serre
The authors consider the problems posed by secondary and associated chondrocalcinosis (CCA) on the basis of a study carried out at many French Rheumatology centres (Centres de Rhumatologie Française) and in the light of data in the literature. CCA is associated with gout in 4 percent of cases, with hyperparathyroidism in 3.9 percent of cases, with haemochromatosis in 1.7 percent of cases and with hypothyroidism in 0.8 percent of cases. The existence of secondary CCA in gout, hyperparathyroidism, haemochromatosis, Wilson's disease, ochronosis, hypophosphatasia and perhaps hypothyroidism seems proven...
October 1977: Revue du Rhumatisme et des Maladies Ostéo-articulaires
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