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https://www.readbyqxmd.com/read/29786783/a-xenograft-model-for-venous-malformation
#1
Jillian Goines, Xian Li, Yuqi Cai, Paula Mobberley-Schuman, Megan Metcalf, Steven J Fishman, Denise M Adams, Adrienne M Hammill, Elisa Boscolo
Vascular malformations are defects caused by the abnormal growth of the vasculature. Among them, venous malformation (VM) is an anomaly characterized by slow-flow vascular lesions with abnormally shaped veins, typically in sponge-like configuration. VMs can expand over years causing disfigurement, obstruction of vital structures, thrombosis, bleeding, and pain. Treatments have been very limited and primarily based on supportive care, compression garments, sclerotherapy, and/or surgical resection. Sirolimus treatment has recently shown efficacy in some patients with complicated vascular anomalies, including VMs...
May 21, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29786180/-bartter-syndrome-severe-rare-orphan-kidney-disease-a-step-towards-therapy-through-pharmacogenetic-and-epidemiological-studies
#2
EDITORIAL
Elena Conte, Paola Imbrici, Dalila Sahbani, Antonella Liantonio, Diana Conte
Bartter syndromes (BS) types 1-5 are rare salt-losing tubulopathies presenting with overlapping clinical phenotypes including marked salt wasting and hypokalemia leading to polyuria, polydipsia, volume contraction, muscle weakness and growth retardation. These diseases are due to an impairment of sodium, potassium, chloride reabsorption caused by mutations in genes encoding for ion channel or transporters expressed in specific nephron tubule segments. Particularly, BS type 3 is a clinically heterogeneous form caused by mutations in CLCNKB gene which encodes the ClC-Kb chloride channel involved in NaCl reabsorption in the renal tubule...
May 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29785535/effects-of-trypsinization-and-of-a-combined-trypsin-collagenase-and-dnase-digestion-on-liberation-and-in-vitro-function-of-satellite-cells-isolated-from-juvenile-porcine-muscles
#3
Claudia Miersch, Katja Stange, Monika Röntgen
Muscle stem cells, termed satellite cells (SC), and SC-derived myogenic progenitor cells (MPC) are involved in postnatal muscle growth, regeneration, and muscle adaptability. They can be released from their natural environment by mechanical disruption and tissue digestion. The literature contains several isolation protocols for porcine SC/MPC including various digestion procedures, but comparative studies are missing. In this report, classic trypsinization and a more complex trypsin, collagenase, and DNase (TCD) digestion were performed with skeletal muscle tissue from 4- to 5-d-old piglets...
May 21, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29784874/select-%C3%AE-arrestins-control-cell-surface-abundance-of-the-mammalian-kir2-1-potassium-channel-in-a-yeast-model
#4
Natalie A Hager, Collin J Krasowski, Timothy D Mackie, Alexander R Kolb, Patrick G Needham, Andrew A Augustine, Alison Dempsey, Christopher Szent-Gyorgyi, Marcel P Bruchez, Daniel J Bain, Adam V Kwiatkowski, Allyson F O'Donnell, Jeffrey L Brodsky
Protein composition at the plasma membrane is tightly regulated, with rapid protein internalization and selective targeting to the cell surface occurring in response to environmental changes. For example, ion channels are dynamically relocalized to or from the plasma membrane in response to physiological alterations, allowing cells and organisms to maintain osmotic and salt homeostasis. To identify additional factors that regulate the selective trafficking of a specific ion channel, we used a yeast model for a mammalian potassium channel, the K+ inwardly rectifying channel Kir2...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29783116/modelling-environment-contamination-with-heavy-metals-in-flathead-grey-mullet-mugil-cephalus-and-upper-sediments-from-north-african-coasts-of-the-mediterranean-sea
#5
Naouel Ouali, Bourhane-Eddine Belabed, Haroun Chenchouni
Heavy metals are a serious hazard for aquatic ecosystems and human health. They negatively affect aquatic life functioning through accumulation resulting physiological/growth disturbances in aquatic lifeforms. This survey focused on the assessment of heavy metal pollution in the Gulf of Annaba (northeastern Algeria), the largest and most diversified industrial hub in Africa, using a multi-compartment approach (water-sediment-biota). The study aims to characterize the spatiotemporal variation of trace metal (TM) contamination and its effects on the growth of the Flathead grey mullet (Mugil cephalus)...
May 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29782610/castration-induces-satellite-cell-activation-that-contributes-to-skeletal-muscle-maintenance
#6
Alanna Klose, Wenxuan Liu, Nicole D Paris, Sophie Forman, John J Krolewski, Kent L Nastiuk, Joe V Chakkalakal
Background: Sarcopenia, the age-related loss of skeletal muscle, is a side effect of androgen deprivation therapy (ADT) for prostate cancer patients. Resident stem cells of skeletal muscle, satellite cells (SCs), are an essential source of progenitors for the growth and regeneration of skeletal muscle. Decreased androgen signaling and deficits in the number and function of SCs are features of aging. Although androgen signaling is known to regulate skeletal muscle, the cellular basis for ADT-induced exacerbation of sarcopenia is unknown...
2018: JCSM rapid communications
https://www.readbyqxmd.com/read/29781092/assimilation-of-nitrogen-and-carbon-isotopes-from-fish-diets-to-otoliths-as-measured-by-nanoscale-secondary-ion-mass-spectrometry
#7
Jen-Chieh Shiao, Kotaro Shirai, Kentaro Tanaka, Naoto Takahata, Yuji Sano, Sung-Yun Hsiao, Der-Chuen Lee, Yung-Che Tseng
RATIONALE: Nitrogen and carbon stable isotope ratios (δ15 N and δ13 C values) of carbonate-bound organic materials in otoliths can provide information to address the biological and ecological functions of fish. Correct interpretation of otolith δ15 N and δ13 C profiles requires knowledge of the metabolic routes of nitrogen and carbon isotopes. However, the isotopic assimilation of δ15 N and δ13 C compositions from diets to otoliths has rarely been investigated. METHODS: This study traced the daily nitrogen and carbon isotopic assimilation between diets and otoliths using nanoscale secondary ion mass spectrometry (NanoSIMS)...
May 21, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29780813/loss-of-heterogeneity-quiescence-and-differentiation-in-muscle-stem-cells
#8
REVIEW
Haser Hasan Sutcu, Miria Ricchetti
Skeletal muscle stem cells in the adult display heterogeneity that has been functionally linked to their behavior, self-renewal capacity, and resistance to stress in hostile environments. Behavioral heterogeneity emerges also during developmental myogenesis. Muscle stem cell diversity may be functionally linked to the changing needs of skeletal muscle regeneration. Intriguingly, dramatic reduction of stem cell diversity, the "clonal drift", that implies loss of stem cells and related expansion of clonally related stem cells has been reported for tissue replacement in several adult tissues and suggested in the zebrafish embryo...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29780359/the-mitotic-and-metabolic-effects-of-phosphatidic-acid-in-the-primary-muscle-cells-of-turbot-scophthalmus-maximus
#9
Tingting Wang, Xuan Wang, Huihui Zhou, Haowen Jiang, Kangsen Mai, Gen He
Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand for aquaculture industry. In this study, the modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, and metabolic pathways were systematically examined in primary muscle cells of turbot ( Scophthalmus maximus ). PA was found to stimulate cell proliferation and promote G1/S phase transition through activation of target of rapamycin signaling pathway. The expression of myogenic regulatory factors, including myoD and follistatin , was upregulated, while that of myogenin and myostatin was downregulated by PA...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29778583/a-novel-view-on-the-pathogenesis-of-complications-after-intravesical-bcg-for-bladder-cancer
#10
Manu P Bilsen, Krista E van Meijgaarden, Hanna K de Jong, Simone A Joosten, Corine Prins, Lucia J M Kroft, Jacqueline T Jonker, Stijn Crobach, Rob C Pelger, Tom H M Ottenhoff, Sandra M Arend
Intravesical Bacillus Calmette-Guérin (BCG) is widely used for high-risk, non-muscle-invasive bladder cancer. We describe four cases which illustrate the spectrum of BCG-induced complications, varying from granulomatous prostatitis to sepsis. Considerable debate exists whether inflammation or infection is the predominant mechanism in the pathogenesis of BCG-disease. In two patients with systemic illness symptoms resolved first after adding prednisone, indicating a principle role for inflammation in systemic disease...
May 17, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29777737/type-i-collagen-induces-mesenchymal-cell-differentiation-into-myofibroblasts-through-yap-induced-tgf-%C3%AE-1-activation
#11
Xiaoling Liu, Xinyu Long, Weiwei Liu, Yeli Zhao, Toshihiko Hayashi, Masayuki Yamato, Kazunori Mizuno, Hitomi Fujisaki, Shunji Hattori, Shin-Ichi Tashiro, Takaaki Ogura, Yuji Atsuzawa, Takashi Ikejima
In organ fibrosis, mechanical stress and transforming growth factor beta-1 (TGF-β1) promote differentiation into myofibroblast from mesenchymal cells, leading to extracellular matrix (ECM) remodeling or active synthesis, deposition or degradation of ECM components. A major component of ECM, type I collagen (col I) triple helical molecules assemble into fibrils or are denatured to gelatin without triple-helicity in remodeling. However, whether changes of ECM components in remodeling have influence on mesenchymal cell differentiation remains elusive...
May 16, 2018: Biochimie
https://www.readbyqxmd.com/read/29777633/hypertrophic-effect-of-inhaled-beta-2-agonist-with-and-without-concurrent-exercise-training-a-randomized-controlled-trial
#12
Søren Jessen, Johan Onslev, Anders Lemminger, Vibeke Backer, Jens Bangsbo, Morten Hostrup
INTRODUCTION: Due to a high prevalence of asthma and exercise-induced bronchoconstriction in elite athletes, there is a high use of beta2 -adrenoceptor agonists (beta2 -agonists) in the athletic population. While anabolic in rodents, no study has been able to detect hypertrophy in humans after chronic beta2 -agonist inhalation. METHODS: We investigated if inhaled beta2 -agonist, terbutaline, alters body composition and metabolic rate with and without concurrent exercise training in healthy young men...
May 19, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29777169/difructose-dianhydride-improves-intestinal-calcium-absorption-wound-healing-and-barrier-function
#13
Sang In Lee, In Ho Kim
The gastrointestinal tract (GIT) is critical for nutrient absorption and is an important barrier against harmful pathogens and antigens. Difructose anhydrides (DFA)-IVs are nondigestible disaccharides that enhance calcium and iron absorption by affecting the intestinal epithelial tissue. However, their effects on intestinal functions are not fully understood. In this study, we performed a feeding trial and found that dietary DFA-IVs improved growth performance, relative breast muscle and liver weight, and digestibility and blood calcium and iron concentrations in broilers...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776718/high-urinary-ferritin-reflects-myoglobin-iron-evacuation-in-dmd-patients
#14
Jérémy Rouillon, Thibaud Lefebvre, Jérôme Denard, Vincent Puy, Raed Daher, Jérôme Ausseil, Aleksandar Zocevic, Paul Fogel, Katell Peoc'h, Brenda Wong, Laurent Servais, Thomas Voit, Herve Puy, Zoubida Karim, Fedor Svinartchouk
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the dystrophin gene leading to the absence of the normal dystrophin protein. The efforts of many laboratories brought new treatments of DMD to the reality, but ongoing and forthcoming clinical trials suffer from absence of valuable biomarkers permitting to follow the outcome of the treatment day by day and to adjust the treatment if needed. In the present study the levels of 128 urinary proteins including growth factors, cytokines and chemokines were compared in urine of DMD patients and age related control subjects by antibody array approach...
March 20, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29775750/the-effects-of-capn1-gene-inactivation-on-the-differential-expression-of-genes-in-skeletal-muscle
#15
William T Olive, Brittney N Keel, Amanda K Lindholm-Perry, Justyna Horodyska, Andrew P Foote
Protein turnover is required for muscle growth and regeneration and several proteolytic enzymes, including the calpains, degrade myofibrillar proteins during this process. In a previous experiment, phenotypic differences were observed between μ-calpain knockout (KO) and wild type (WT) mice, including nutrient accretion and fiber type differences. These changes were particularly evident as the animals aged. Thus, we utilized 18 mice (9 KO and 9 WT) to compare transcript abundance to identify differentially expressed genes (DEGs) at 52 wk of age...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29775666/the-effect-of-syndecan-4-and-glypican-1-knockdown-on-the-proliferation-and-differentiation-of-turkey-satellite-cells-differing-in-age-and-growth-rates
#16
Sandra G Velleman, Daniel L Clark, Jeffrey R Tonniges
Posthatch skeletal muscle growth requires myogenic satellite cells and the dynamic expression of cell membrane-associated proteins. The membrane associated heparan sulfate proteoglycans, syndecan-4 and glypican-1, link the satellite cell niche to the intracellular environment. Sydnecan-4 and glypican-1 are differentially expressed with age in turkey satellite cells and their over-expression impacts both satellite cell proliferation and differentiation, but their effect on satellite cells from lines with different growth potentials is not known...
May 15, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29775222/abca1-inhibits-pdgf-induced-proliferation-and-migration-of-rat-airway-smooth-muscle-cell-through-blocking-tlr2-nf-%C3%AE%C2%BAb-nfatc1-signaling
#17
Wei Cheng, Kun Yan, Yanni Chen, Wen Zhang, Zongzheng Ji, Chengxue Dang
Airway remodeling is a key feature of asthma, characterized by abnormal proliferation and migration of airway smooth muscle cells (ASMCs). ABCA1, a member of the ATP-binding cassette family of active transporters, plays an essential role in the progression of lung diseases. However, the contributions of ABCA1 in ASMCs remain to be explored. The purpose of the present study was to investigate the functional role and potential molecular mechanism of ABCA1 in platelet derived growth factor (PDGF)-induced primary rat ASMC proliferation and migration...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774991/aggregate-mesenchymal-stem-cell-delivery-ameliorates-the-regenerative-niche-for-muscle-repair
#18
Marissa A Ruehle, Hazel Y Stevens, Aaron M Beedle, Robert E Guldberg, Jarrod A Call
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease due to the absence of the dystrophin protein from the muscle cell membrane which renders the muscle susceptible to continuous damage. In DMD patients, muscle weakness, together with cycles of degeneration/regeneration and replacement with non-contractile tissue, limit mobility and lifespan. Since the loss of dystrophin result in loss of polarity and a reduction in the number of self-renewing satellite cells, it is postulated that these patients could achieve an improved quality of life if delivered cells could restore satellite cell function...
May 18, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29772187/platelet-rich-plasma-releasate-promotes-regeneration-and-decreases-inflammation-and-apoptosis-of-injured-skeletal-muscle
#19
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S Pang
BACKGROUND: Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on the authors' previous study, PRP releasate can promote proliferation and migration of skeletal muscle cells in vitro, so animal studies are performed to support the use of PRP to treat muscle injury in vivo. PURPOSE: To investigate the effect of PRP releasate on regeneration of injured muscle, as well as its effect on inflammatory reaction and cell apoptosis, in the early stages of the muscle-healing process...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29770950/heme-and-non-heme-iron-on-growth-performances-blood-parameters-tissue-mineral-concentration-and-intestinal-morphology-of-weanling-pigs
#20
Zhao Zhuo, Xiaonan Yu, Sisi Li, Shenglin Fang, Jie Feng
This experiment was conducted to evaluate the effects of heme and non-heme iron sources on growth performances, blood parameters, tissue mineral concentration, and intestinal morphology in weanling pigs. At 25 days of age, 32 newly weaned piglets (Duroc × Landrace × Yorkshire; 8.66 ± 0.59 kg) were allocated to one of the following dietary treatments: control group (basal diet with no extra iron addition), FeSO4 group (basal diet + 100 mg Fe/kg as FeSO4 ), Fe-Gly group (basal diet + 100 mg Fe/kg as Fe-Gly), and Heme group (basal diet + 100 mg Fe/kg as Heme)...
May 16, 2018: Biological Trace Element Research
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