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major depression & vulnerability

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https://www.readbyqxmd.com/read/28537802/seasonal-pattern-in-bipolar-disorders-and-cardio-vascular-risk-factors-a-study-from-the-face-bd-cohort
#1
Pierre A Geoffroy, Ophelia Godin, Diane Mahee, Chantal Henry, Valérie Aubin, Jean-Michel Azorin, Thierry Bougerol, Philippe Courtet, Sébastien Gard, Jean-Pierre Kahn, Christine Passerieux, Marion Leboyer, Frank Bellivier, Bruno Etain
Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. This study examines whether a SP in BD is associated with an increased risk of MetS and its sub-components. One thousand four hundred and seventy-one outpatients with BD were systematically enrolled from 2009 to 2016...
May 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28523546/histone-modifications-in-major-depressive-disorder-and-related-rodent-models
#2
Jan M Deussing, Mira Jakovcevski
Major depressive disorder (MDD) is a multifactorial disease, weakly linked to multiple genetic risk factors. In contrast to that, environmental factors and "gene × environment" interaction between specific risk genes and environmental factors, such as severe or early stress exposure, have been strongly linked to MDD vulnerability. Stressors can act on the interface between an organism and the environment, the epigenome. The molecular foundation for the impact of stressors on the risk to develop MDD is based on the hormonal stress response itself: the glucocorticoid receptor (GR, encoded by NR3C1)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28506823/hyperammonemia-compromises-glutamate-metabolism-and-reduces-bdnf-in-the-rat-hippocampus
#3
Fabiana Galland, Elisa Negri, Carollina Da Ré, Fernanda Fróes, Liliane Strapazzon, Maria Cristina Guerra, Lucas Silva Tortorelli, Carlos-Alberto Gonçalves, Marina Concli Leite
Ammonia is putatively the major toxin associated with hepatic encephalopathy (HE), a neuropsychiatric manifestation that results in cognitive impairment, poor concentration and psychomotor alterations. The hippocampus, a brain region involved in cognitive impairment and depressive behavior, has been studied less than neocortical regions. Herein, we investigated hippocampal astrocyte parameters in a hyperammonemic model without hepatic lesion and in acute hippocampal slices exposed to ammonia. We also measured hippocampal BDNF, a neurotrophin commonly related to synaptic plasticity and cognitive deficit, and peripheral S100B protein, used as a marker for brain damage...
May 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28504561/sexual-violence-and-intimate-partner-violence-in-college-women-with-a-mental-health-and-or-behavior-disability
#4
Amy Bonomi, Emily Nichols, Rebecca Kammes, Troye Green
OBJECTIVES: We address questions about (1) how college women with a disability experience sexual violence (SV) and intimate partner violence (IPV) across partners, including disability-specific abuse and (2) how SV/IPV impacts psychological, behavioral, physical, and academic life domains. METHODS/DESIGN: Twenty-seven female college students (mean age, 21.2; 66.6% white; 66.6% heterosexual) were randomly sampled from university registrar records. To be eligible for the study, students had to have at least one experience of SV/IPV since age 18 and a disability (88...
May 15, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28491024/the-serotonin-transporter-and-early-life-stress-translational-perspectives
#5
REVIEW
Danielle J Houwing, Bauke Buwalda, Eddy A van der Zee, Sietse F de Boer, Jocelien D A Olivier
The interaction between the serotonin transporter (SERT) linked polymorphic region (5-HTTLPR) and adverse early life stressing (ELS) events is associated with enhanced stress susceptibility and risk to develop mental disorders like major depression, anxiety, and aggressiveness. In particular, human short allele carriers are at increased risk. This 5-HTTLPR polymorphism is absent in the rodent SERT gene, but heterozygous SERT knockout rodents (SERT(+/-)) show several similarities to the human S-allele carrier, therefore creating an animal model of the human situation...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28486706/association-of-anhedonia-with-adolescent-smoking-susceptibility-and-initiation
#6
Matthew D Stone, Janet Audrain-McGovern, Adam M Leventhal
Introduction: Emerging literature implicates anhedonia-diminished capacity to experience pleasure-as a maintaining factor underlying cigarette smoking in adults. The role of anhedonia in adolescent smoking uptake has largely been uninvestigated, leaving unclear whether anhedonia is associated with smoking initiation and with psychosocial determinants of susceptibility to smoking initiation that could be targeted in prevention. This study examined the association of anhedonia with smoking initiation (ever smoke: yes/no) and factors indicative of susceptibility to smoking initiation among never-smokers (smoking outcome expectancies, curiosity about smoking, and willingness and future intention to initiate smoking)...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28476213/reprint-of-using-neuroimaging-to-individualize-tms-treatment-for-depression-toward-a-new-paradigm-for-imaging-guided-intervention
#7
Bruce M Luber, Simon Davis, Elisabeth Bernhardt, Andrada Neacsiu, Lori Kwapil, Sarah H Lisanby, Timothy J Strauman
The standard clinical technique for using repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) is associated with limited efficacy to date. Such limited efficacy may be due to reliance on scalp-based targeting rather than state-of-the-science methods which incorporate fMRI-guided neuronavigation based on a specific model of neurocircuit dysfunction. In this review, we examine such a specific model drawn from regulatory focus theory, which postulates two brain/behavior systems, the promotion and prevention systems, underlying goal pursuit...
May 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28470399/predicting-relapse-with-individual-residual-symptoms-in-major-depressive-disorder-a-reanalysis-of-the-star-d-data
#8
Hitoshi Sakurai, Takefumi Suzuki, Kimio Yoshimura, Masaru Mimura, Hiroyuki Uchida
BACKGROUND: Residual symptoms are detrimental to prognosis in major depressive disorder (MDD); however, little is known about the contribution of each residual symptom in predicting outcomes. The objective of this analysis was to identify which individual symptoms, based on self-report and clinician interview, could predict subsequent relapse. METHODS: The data of 1133 outpatients with nonpsychotic MDD who entered a 12-month naturalistic follow-up phase after achieving remission with level 1 treatment (i...
May 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28464113/breeding-and-genetics-symposium-climate-change-and-selective-breeding-in-aquaculture
#9
P Sae-Lim, A Kause, H A Mulder, I Olesen
Aquaculture is the fastest growing food production sector and it contributes significantly to global food security. Based on Food and Agriculture Organization (FAO) of the United Nations, aquaculture production must increase significantly to meet the future global demand for aquatic foods in 2050. According to Intergovernmental Panel on Climate Change (IPCC) and FAO, climate change may result in global warming, sea level rise, changes of ocean productivity, freshwater shortage, and more frequent extreme climate events...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28463239/subcortical-brain-structure-and-suicidal-behaviour-in-major-depressive-disorder-a-meta-analysis-from-the-enigma-mdd-working-group
#10
M E Rentería, L Schmaal, D P Hibar, B Couvy-Duchesne, L T Strike, N T Mills, G I de Zubicaray, K L McMahon, S E Medland, N A Gillespie, S N Hatton, J Lagopoulos, D J Veltman, N van der Wee, T G M van Erp, K Wittfeld, H J Grabe, A Block, K Hegenscheid, H Völzke, I M Veer, H Walter, K Schnell, E Schramm, C Normann, D Schoepf, C Konrad, B Zurowski, B R Godlewska, P J Cowen, B W J H Penninx, N Jahanshad, P M Thompson, M J Wright, N G Martin, H Christensen, I B Hickie
The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts...
May 2, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28452902/delirium-associated-with-fluoxetine-discontinuation-a-case-report
#11
Kuang-Yuan Fan, Hsing-Cheng Liu
BACKGROUND: Withdrawal symptoms on selective serotonin reuptake inhibitor (SSRI) discontinuation have raised clinical attention increasingly. However, delirium is rarely reported in the SSRI discontinuation syndrome. CASE: We report a case of delirium developing after fluoxetine discontinuation in a 65-year-old female patient with major depressive disorder. She experienced psychotic depression with limited response to treatment of fluoxetine 40 mg/d and quetiapine 100 mg/d for 3 months...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28451473/blunted-reward-processing-in-remitted-melancholic-depression
#12
Anna Weinberg, Stewart A Shankman
Blunted reward response appears to be a trait-like marker of vulnerability for Major Depressive Disorder (MDD). As such, it should be present in remitted individuals; however, depression is a heterogeneous syndrome. Reward-related impairments may be more pronounced in individuals with melancholic depression. The present study examined neural responses to rewards in remitted melancholic depression (rMD; N = 29), remitted non-melancholic depression (rNMD; N = 56), and healthy controls (HC; N = 81). Event-related potentials to monetary gain and loss were recorded during a simple gambling paradigm...
January 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28451076/dsm-5-and-icd-11-as-competing-models-of-ptsd-in-preadolescent-children-exposed-to-a-natural-disaster-assessing-validity-and-co-occurring-symptomatology
#13
Annette M La Greca, BreAnne A Danzi, Sherilynn F Chan
Background: Major revisions have been made to the DSM and ICD models of post-traumatic stress disorder (PTSD). However, it is not known whether these models fit children's post-trauma responses, even though children are a vulnerable population following disasters. Objective: Using data from Hurricane Ike, we examined how well trauma-exposed children's symptoms fit the DSM-IV, DSM-5 and ICD-11 models, and whether the models varied by gender. We also evaluated whether elevated symptoms of depression and anxiety characterized children meeting PTSD criteria based on DSM-5 and ICD-11...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28450265/construct-and-face-validity-of-a-new-model-for-the-three-hit-theory-of-depression-using-pacap-mutant-mice-on-cd1-background
#14
József Farkas, László Á Kovács, László Gáspár, Anna Nafz, Tamás Gaszner, Balázs Ujvári, Viktória Kormos, Valér Csernus, Hitoshi Hashimoto, Dóra Reglődi, Balázs Gaszner
Major depression is a common cause of chronic disability. Despite decades of efforts, no equivocally accepted animal model is available for studying depression. We tested the validity of a new model based on the three-hit concept of vulnerability and resilience. Genetic predisposition (hit 1, mutation of pituitary adenylate cyclase-activating polypeptide, PACAP gene), early-life adversity (hit 2, 180-min maternal deprivation, MD180) and chronic variable mild stress (hit 3, CVMS) were combined. Physical, endocrinological, behavioral and functional morphological tools were used to validate the model...
April 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28443533/childhood-adversity-adult-stress-and-the-risk-of-major-depression-or-generalized-anxiety-disorder-in-us-soldiers-a-test-of-the-stress-sensitization-hypothesis
#15
G Bandoli, L Campbell-Sills, R C Kessler, S G Heeringa, M K Nock, A J Rosellini, N A Sampson, M Schoenbaum, R J Ursano, M B Stein
BACKGROUND: The stress sensitization theory hypothesizes that individuals exposed to childhood adversity will be more vulnerable to mental disorders from proximal stressors. We aimed to test this theory with respect to risk of 30-day major depressive episode (MDE) and generalized anxiety disorder (GAD) among new US Army soldiers. METHODS: The sample consisted of 30 436 new soldier recruits in the Army Study to Assess Risk and Resilience (Army STARRS). Generalized linear models were constructed, and additive interactions between childhood maltreatment profiles and level of 12-month stressful experiences on the risk of 30-day MDE and GAD were analyzed...
April 26, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28432794/posttraumatic-stress-and-anxiety-in-patients-with-an-implantable-cardioverter-defibrillator-trajectories-and-vulnerability-factors
#16
M Habibović, J Denollet, S S Pedersen
BACKGROUND: Implantable cardioverter defibrillator (ICD) therapy is first-line treatment for the primary and secondary prevention of sudden cardiac death. Despite the unequivocal medical benefits, living with an ICD may affect patients' psychological functioning and general well-being. We examined the trajectories of symptoms of posttraumatic stress disorder (PTSD) and anxiety in patients with an ICD and the vulnerability factors associated with an increased risk of symptoms of PTSD and anxiety...
April 22, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28428806/is-low-total-cholesterol-levels-associated-with-suicide-attempt-in-depressive-patients
#17
A Messaoud, R Mensi, A Mrad, A Mhalla, I Azizi, B Amemou, I Trabelsi, M H Grissa, N Haj Salem, A Chadly, W Douki, M F Najjar, L Gaha
BACKGROUND: Patients with major depressive disorder (MDD) have a high risk of suicide. Many pathophysiological factors involved in MDD and suicide such us a low cholesterol levels have been associated with MDD and increased vulnerability to suicide. In this study, we investigate the relation between lipid parameters and suicide risk in patients with MDD. METHODS: Plasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were determined in 160 patients meeting the DSM-IV-TR criteria for MDD (110 patients without suicidal behavior and 52 suicidal attempters) and 151 healthy controls...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28425449/the-impact-of-treatments-for-depression-on-the-dynamic-network-structure-of-mental-states-two-randomized-controlled-trials
#18
Evelien Snippe, Wolfgang Viechtbauer, Nicole Geschwind, Annelie Klippel, Peter de Jonge, Marieke Wichers
Evidence is growing that vulnerability to depression may be characterized by strong negative feedback loops between mental states. It is unknown whether such dynamics between mental states can be altered by treatment. This study examined whether treatment with imipramine or treatment with Mindfulness-Based Cognitive Therapy (MBCT) reduces the connectivity within dynamic networks of mental states in individuals with depressive symptoms. In the Imipramine trial, individuals diagnosed with major depression were randomized to imipramine treatment or placebo-pill treatment (n = 50)...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419611/well-being-therapy-in-depression-new-insights-into-the-role-of-psychological-well-being-in-the-clinical-process
#19
Giovanni A Fava, Fiammetta Cosci, Jenny Guidi, Elena Tomba
A specific psychotherapeutic strategy for increasing psychological well-being and resilience, well-being therapy (WBT), has been developed and validated in a number of randomized controlled trials. The findings indicate that flourishing and resilience can be promoted by specific interventions leading to a positive evaluation of one's self, a sense of continued growth and development, the belief that life is purposeful and meaningful, the possession of quality relations with others, the capacity to manage effectively one's life, and a sense of self-determination...
April 18, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28415589/gabaergic-neurons-in-nucleus-accumbens-are-correlated-to-resilience-and-vulnerability-to-chronic-stress-for-major-depression
#20
Zhaoming Zhu, Guangyan Wang, Ke Ma, Shan Cui, Jin-Hui Wang
BACKGROUND: Major depression, persistent low mood, is one of common psychiatric diseases. Chronic stressful life is believed to be a major risk factor that leads to dysfunctions of the limbic system. However, a large number of the individuals with experiencing chronic stress do not suffer from major depression, called as resilience. Endogenous mechanisms underlying neuronal invulnerability to chronic stress versus major depression are largely unknown. As GABAergic neurons are vulnerable to chronic stress and their impairments is associated with major depression, we have examined whether the invulnerability of GABAergic neurons in the limbic system is involved in resilience...
March 21, 2017: Oncotarget
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