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major depression & vulnerability

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https://www.readbyqxmd.com/read/28443533/childhood-adversity-adult-stress-and-the-risk-of-major-depression-or-generalized-anxiety-disorder-in-us-soldiers-a-test-of-the-stress-sensitization-hypothesis
#1
G Bandoli, L Campbell-Sills, R C Kessler, S G Heeringa, M K Nock, A J Rosellini, N A Sampson, M Schoenbaum, R J Ursano, M B Stein
BACKGROUND: The stress sensitization theory hypothesizes that individuals exposed to childhood adversity will be more vulnerable to mental disorders from proximal stressors. We aimed to test this theory with respect to risk of 30-day major depressive episode (MDE) and generalized anxiety disorder (GAD) among new US Army soldiers. METHODS: The sample consisted of 30 436 new soldier recruits in the Army Study to Assess Risk and Resilience (Army STARRS). Generalized linear models were constructed, and additive interactions between childhood maltreatment profiles and level of 12-month stressful experiences on the risk of 30-day MDE and GAD were analyzed...
April 26, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28432794/posttraumatic-stress-and-anxiety-in-patients-with-an-implantable-cardioverter-defibrillator-trajectories-and-vulnerability-factors
#2
M Habibović, J Denollet, S S Pedersen
BACKGROUND: Implantable cardioverter defibrillator (ICD) therapy is first-line treatment for the primary and secondary prevention of sudden cardiac death. Despite the unequivocal medical benefits, living with an ICD may affect patients' psychological functioning and general well-being. We examined the trajectories of symptoms of posttraumatic stress disorder (PTSD) and anxiety in patients with an ICD and the vulnerability factors associated with an increased risk of symptoms of PTSD and anxiety...
April 22, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28428806/is-low-total-cholesterol-levels-associated-with-suicide-attempt-in-depressive-patients
#3
A Messaoud, R Mensi, A Mrad, A Mhalla, I Azizi, B Amemou, I Trabelsi, M H Grissa, N Haj Salem, A Chadly, W Douki, M F Najjar, L Gaha
BACKGROUND: Patients with major depressive disorder (MDD) have a high risk of suicide. Many pathophysiological factors involved in MDD and suicide such us a low cholesterol levels have been associated with MDD and increased vulnerability to suicide. In this study, we investigate the relation between lipid parameters and suicide risk in patients with MDD. METHODS: Plasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) were determined in 160 patients meeting the DSM-IV-TR criteria for MDD (110 patients without suicidal behavior and 52 suicidal attempters) and 151 healthy controls...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28425449/the-impact-of-treatments-for-depression-on-the-dynamic-network-structure-of-mental-states-two-randomized-controlled-trials
#4
Evelien Snippe, Wolfgang Viechtbauer, Nicole Geschwind, Annelie Klippel, Peter de Jonge, Marieke Wichers
Evidence is growing that vulnerability to depression may be characterized by strong negative feedback loops between mental states. It is unknown whether such dynamics between mental states can be altered by treatment. This study examined whether treatment with imipramine or treatment with Mindfulness-Based Cognitive Therapy (MBCT) reduces the connectivity within dynamic networks of mental states in individuals with depressive symptoms. In the Imipramine trial, individuals diagnosed with major depression were randomized to imipramine treatment or placebo-pill treatment (n = 50)...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419611/well-being-therapy-in-depression-new-insights-into-the-role-of-psychological-well-being-in-the-clinical-process
#5
Giovanni A Fava, Fiammetta Cosci, Jenny Guidi, Elena Tomba
A specific psychotherapeutic strategy for increasing psychological well-being and resilience, well-being therapy (WBT), has been developed and validated in a number of randomized controlled trials. The findings indicate that flourishing and resilience can be promoted by specific interventions leading to a positive evaluation of one's self, a sense of continued growth and development, the belief that life is purposeful and meaningful, the possession of quality relations with others, the capacity to manage effectively one's life, and a sense of self-determination...
April 18, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28415589/gabaergic-neurons-in-nucleus-accumbens-are-correlated-to-resilience-and-vulnerability-to-chronic-stress-for-major-depression
#6
Zhaoming Zhu, Guangyan Wang, Ke Ma, Shan Cui, Jin-Hui Wang
BACKGROUND: Major depression, persistent low mood, is one of common psychiatric diseases. Chronic stressful life is believed to be a major risk factor that leads to dysfunctions of the limbic system. However, a large number of the individuals with experiencing chronic stress do not suffer from major depression, called as resilience. Endogenous mechanisms underlying neuronal invulnerability to chronic stress versus major depression are largely unknown. As GABAergic neurons are vulnerable to chronic stress and their impairments is associated with major depression, we have examined whether the invulnerability of GABAergic neurons in the limbic system is involved in resilience...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412893/public-attitudes-and-feelings-of-warmth-toward-women-and-men-experiencing-depression-during-the-perinatal-period
#7
Jennifer N Felder, Sarah Banchefsky, Bernadette Park, Sona Dimidjian
OBJECTIVE: Depression is a major public health concern and often goes untreated. In response to a growing body of research documenting stigma as a barrier to depression care, this study focused on examining public stigma toward potentially vulnerable subpopulations. METHODS: Participants (N=241) were recruited from Amazon's Mechanical Turk and randomly assigned to provide anonymous ratings on attitudes and feelings of warmth toward pregnant women and expectant fathers experiencing depression, mothers and fathers experiencing postpartum depression, or women and men experiencing depression during nonperinatal periods...
April 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28402002/mental-health-and-associated-factors-among-young-offenders-in-chile-a-cross-sectional-study
#8
Jorge Gaete, Nicolas Labbé, Paloma Del Villar, Catalina Allende, Ricardo Araya, Eduardo Valenzuela
BACKGROUND: Few studies in Latin America have explored mental disorder among young offenders, or variables associated with it. AIMS: Our aim was to test for associations between childhood adversity or substance misuse and psychiatric disorders among young offenders. METHODS: Sentenced adolescent offenders were recruited from young offenders' institutions or community centres provided by the Chilean National Service for Minors. Psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview, conducted by trained psychologists...
April 12, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28396255/the-recent-progress-in-animal-models-of-depression
#9
REVIEW
Qingzhong Wang, Matthew A Timberlake, Kevin Prall, Yogesh Dwivedi
Major depression disorder (MDD) is a debilitating mental illness with significant morbidity and mortality. Despite the growing number of studies that have emerged, the precise underlying mechanisms of MDD remain unknown. When studying MDD, tissue samples like peripheral blood or post-mortem brain samples are used to elucidate underlying mechanisms. Unfortunately, there are many uncontrollable factors with such samples such as medication history, age, time after death before post-mortem tissue was collected, age, sex, race, and living conditions...
April 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28390440/prevalence-of-and-risk-factors-for-minor-and-major-depression-among-community-dwelling-older-adults-in-taiwan
#10
Chi-Shin Wu, Shu-Han Yu, Chun-Yi Lee, Han-Yun Tseng, Yen-Feng Chiu, Chao Agnes Hsiung
BACKGROUND: This study was conducted to estimate prevalence rates and risk factors for late-life depression in a large nationwide representative sample from Taiwan. METHODS: A total of 5,664, randomly sampled individuals aged ≥55 years were enrolled. Clinically, relevant depressive symptoms were classified using the Center for Epidemiological Studies Depression Scale (CES-D score ≥16), and major depression was confirmed using the Primary Care Evaluation of Mental Disorders...
April 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28387209/college-binge-drinking-and-its-association-with-depression-and-anxiety-a-prospective-observational-study
#11
R Nourse, P Adamshick, J Stoltzfus
OBJECTIVE: Binge drinking is a significant public health problem across college campuses in the United States. Despite substantial research and the use of evidence-based methods, the binge drinking culture remains an obstinate health crisis on campuses. This study examined the current binge drinking rate on a selected college campus, the association between binge drinking and anxiety and depression as well as the associated consequences of students' alcohol use. METHODS: A sample of 201 students from a small, private Mid-Atlantic college completed validated scales as well as demographics and questionnaires...
March 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/28373849/deep-brain-stimulation-in-anorexia-nervosa-hope-for-the-hopeless-or-exploitation-of-the-vulnerable-the-oxford-neuroethics-gold-standard-framework
#12
Rebecca J Park, Ilina Singh, Alexandra C Pike, Jacinta O A Tan
Neurosurgical interventions for psychiatric disorders have a long and troubled history (1, 2) but have become much more refined in the last few decades due to the rapid development of neuroimaging and robotic technologies (2). These advances have enabled the design of less invasive techniques, which are more focused, such as deep brain stimulation (DBS) (3). DBS involves electrode insertion into specific neural targets implicated in pathological behavior, which are then repeatedly stimulated at adjustable frequencies...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28372994/neural-activation-during-cognitive-reappraisal-in-girls-at-high-risk-for-depression
#13
F Simsek, K Oguz, O Kitis, S T Akan, M J Kempton, A S Gonul
OBJECTIVE: Although emotion dysregulation, one of the core features of depression, has long been thought to be a vulnerability factor for major depressive disorder (MDD), surprisingly few functional magnetic resonance imaging (fMRI) studies have investigated neural correlates of emotion regulation strategies in unaffected high risk individuals. METHOD: Sixteen high risk (RSK) young women and fifteen matched low risk controls (CTL) were scanned using fMRI while performing an emotion regulation task...
March 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28369312/depressive-disorder-subtypes-as-predictors-of-incident-obesity-in-us-adults-moderation-by-race-ethnicity
#14
Brittanny M Polanka, Elizabeth A Vrany, Jay Patel, Jesse C Stewart
We compared the relative importance of atypical major depressive disorder (MDD), nonatypical MDD, and dysthymic disorder in predicting 3-year obesity incidence and change in body mass index and determined whether race/ethnicity moderated these relationships. We examined data from 17,787 initially nonobese adults in the National Epidemiologic Survey on Alcohol and Related Conditions waves 1 (2001-2002) and 2 (2004-2005) who were representative of the US population. Lifetime subtypes of depressive disorders were determined using a structured interview, and obesity outcomes were computed from self-reported height and weight...
March 22, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28365538/co-infection-with-hiv-associated-with-reduced-vulnerability-to-symptoms-of-depression-during-antiviral-treatment-for-hepatitis-c
#15
Renata Fialho, Marco Pereira, Neil Harrison, Jennifer Rusted, Richard Whale
In this prospective study, we examined new-onset major depressive disorder (MDD) and the differential expression of depressive symptoms in a sample of 132 HCV mono-infected and 40 HIV/HCV co-infected patients initiating pegylated interferon-based treatment, including protease inhibitor therapy. The semi-structured clinical interview (SCID-I) was used to assess MDD. Severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Of the total sample, 60 patients (34.9%) developed SCID-I defined MDD during antiviral treatment...
March 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28361870/associations-between-daily-affective-instability-and-connectomics-in-functional-subnetworks-in-remitted-patients-with-recurrent-major-depressive-disorder
#16
Michelle N Servaas, Harriëtte Riese, Remco J Renken, Marieke Wichers, Jojanneke A Bastiaansen, Caroline A Figueroa, Hanneke Geugies, Roel Jt Mocking, Linda Geerligs, Jan-BernardC Marsman, André Aleman, Aart H Schene, Robert A Schoevers, Henricus G Ruhé
Remitted patients with major depressive disorder (rMDD) often report more fluctuations in mood as residual symptomatology. It is unclear how this affective instability is associated with information processing related to the default mode (DMS), salience/reward (SRS) and fronto-parietal (FPS) subnetworks in rMDD patients at high risk of recurrence (rrMDD). Sixty-two unipolar, drug-free rrMDD patients (⩾2 MDD-episodes) and 41 HC (HC) were recruited. We used Experience Sampling Methodology (ESM) to monitor mood/cognitions (10 times a day for 6 days) and calculated affective instability using the mean adjusted absolute successive difference...
March 31, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28326741/the-impact-of-childhood-adversities-on-anxiety-and-depressive-disorders-in-adulthood
#17
Marketa Marackova, Jan Prasko, Stanislav Matousek, Klara Latalova, Radovan Hruby, Michaela Holubova, Milos Slepecky, Kristyna Vrbova, Ales Grambal
OBJECTIVES: The childhood adversities model is generally accepted as a predictor of adult psychopathology vulnerability. It stems from child development theories, but the question remains as of how well solid research supports it. The aim of this article is to give a review of the studies concerning childhood adversities and their impact on the development of anxiety disorders and major depressive disorder in adulthood. METHOD: A computerized search of the MEDLINE database of publications up to 31 March 2016 was done, using the keywords "childhood adversities, abuse, maltreatment, bullying" and "anxiety disorders, depressive disorder"...
December 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28320224/identification-of-common-neural-circuit-disruptions-in-cognitive-control-across-psychiatric-disorders
#18
Lisa M McTeague, Julia Huemer, David M Carreon, Ying Jiang, Simon B Eickhoff, Amit Etkin
OBJECTIVE: Cognitive deficits are a common feature of psychiatric disorders. The authors investigated the nature of disruptions in neural circuitry underlying cognitive control capacities across psychiatric disorders through a transdiagnostic neuroimaging meta-analysis. METHOD: A PubMed search was conducted for whole-brain functional neuroimaging articles published through June 2015 that compared activation in patients with axis I disorders and matched healthy control participants during cognitive control tasks...
March 21, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28279571/sex-dependent-mental-illnesses-and-mitochondria
#19
REVIEW
Akiko Shimamoto, Virginie Rappeneau
The prevalence of some mental illnesses, including major depression, anxiety-, trauma-, and stress-related disorders, some substance use disorders, and later onset of schizophrenia, is higher in women than men. While the higher prevalence in women could simply be explained by socioeconomic determinants, such as income, social status, or cultural background, extensive studies show sex differences in biological, pharmacokinetic, and pharmacological factors contribute to females' vulnerability to these mental illnesses...
March 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28278742/cognitive-reactivity-as-outcome-and-working-mechanism-of-mindfulness-based-cognitive-therapy-for-recurrently-depressed-patients-in-remission
#20
M B Cladder-Micus, J van Aalderen, A R T Donders, J Spijker, J N Vrijsen, A E M Speckens
Major depressive disorder is a prevalent condition with high relapse rates. There is evidence that cognitive reactivity is an important vulnerability factor for the recurrence of depression. Mindfulness-based interventions are designed to reduce relapse rates, with cognitive reactivity as one of the proposed working mechanisms. In a randomised controlled trial we compared the effect of mindfulness-based cognitive therapy (MBCT) with treatment-as-usual (TAU) on cognitive reactivity in recurrently depressed patients (N = 115)...
February 7, 2017: Cognition & Emotion
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