Srirupa Chatterjee, Priya Luthra, Ekaterina Esaulova, Eugene Agapov, Benjamin C Yen, Dominika M Borek, Megan R Edwards, Anuradha Mittal, David S Jordan, Parameshwar Ramanan, Martin L Moore, Rohit V Pappu, Michael J Holtzman, Maxim N Artyomov, Christopher F Basler, Gaya K Amarasinghe, Daisy W Leung
Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatric, elderly and immune-compromised populations1,2 . A gap in our understanding of hRSV disease pathology is the interplay between virally encoded immune antagonists and host components that limit hRSV replication. hRSV encodes for non-structural (NS) proteins that are important immune antagonists3-6 ; however, the role of these proteins in viral pathogenesis is incompletely understood. Here, we report the crystal structure of hRSV NS1 protein, which suggests that NS1 is a structural paralogue of hRSV matrix (M) protein...
June 30, 2017: Nature Microbiology