keyword
https://read.qxmd.com/read/32585323/conserved-t-cell-epitopes-of-respiratory-syncytial-virus-rsv-delivered-by-recombinant-live-attenuated-influenza-vaccine-viruses-efficiently-induce-rsv-specific-lung-localized-memory-t-cells-and-augment-influenza-specific-resident-memory-t-cell-responses
#21
JOURNAL ARTICLE
Victoria Matyushenko, Tatiana Kotomina, Igor Kudryavtsev, Daria Mezhenskaya, Polina Prokopenko, Anastasia Matushkina, Konstantin Sivak, Arman Muzhikyan, Larisa Rudenko, Irina Isakova-Sivak
Respiratory syncytial virus (RSV) can cause recurrent infection in people because it does not stimulate a long-lived immunological memory. There is an urgent need to develop a safe and efficacious vaccine against RSV that would induce immunological memory without causing immunopathology following natural RSV infection. We have previously generated two recombinant live attenuated influenza vaccine (LAIV) viruses that encode immunodominant T-cell epitopes of RSV M2 protein in the neuraminidase or NS1 genes. These chimeric vaccines afforded protection against influenza and RSV infection in mice, without causing pulmonary eosinophilia or inflammatory RSV disease...
June 22, 2020: Antiviral Research
https://read.qxmd.com/read/32324238/azithromycin-treatment-vs-placebo-in-children-with-respiratory-syncytial-virus-induced-respiratory-failure-a-phase-2-randomized-clinical-trial
#22
RANDOMIZED CONTROLLED TRIAL
Michele Kong, Wei Wei Zhang, Kate Sewell, Gregory Gorman, Hui-Chien Kuo, Inmaculada Aban, Namasivayam Ambalavanan, Richard J Whitley
IMPORTANCE: Despite a high disease burden, there is no effective treatment for respiratory syncytial virus (RSV) infection. OBJECTIVES: To determine whether administration of azithromycin (AZM) to children with RSV-induced respiratory failure is safe and to define the effect of AZM therapy on nasal matrix metalloproteinase 9 (MMP-9) levels. DESIGN, SETTING, AND PARTICIPANTS: This randomized, double-blind, placebo-controlled phase 2 trial was conducted at a single tertiary pediatric intensive care unit from February 2016 to February 2019...
April 1, 2020: JAMA Network Open
https://read.qxmd.com/read/32216549/impact-of-respiratory-syncytial-virus-infection-on-host-functions-implications-for-antiviral-strategies
#23
REVIEW
MengJie Hu, Marie A Bogoyevitch, David A Jans
Respiratory syncytial virus (RSV) is one of the leading causes of viral respiratory tract infection in infants, the elderly, and the immunocompromised worldwide, causing more deaths each year than influenza. Years of research into RSV since its discovery over 60 yr ago have elucidated detailed mechanisms of the host-pathogen interface. RSV infection elicits widespread transcriptomic and proteomic changes, which both mediate the host innate and adaptive immune responses to infection, and reflect RSV's ability to circumvent the host stress responses, including stress granule formation, endoplasmic reticulum stress, oxidative stress, and programmed cell death...
October 1, 2020: Physiological Reviews
https://read.qxmd.com/read/31622448/respiratory-syncytial-virus-nonstructural-proteins-1-and-2-exceptional-disrupters-of-innate-immune-responses
#24
REVIEW
Koen Sedeyn, Bert Schepens, Xavier Saelens
Human respiratory syncytial virus (RSV) is the most important cause of acute lower respiratory tract disease in infants worldwide. As a first line of defense against respiratory infections, innate immune responses, including the production of type I and III interferons (IFNs), play an important role. Upon infection with RSV, multiple pattern recognition receptors (PRRs) can recognize RSV-derived pathogen-associated molecular patterns (PAMPs) and mount innate immune responses. Retinoic-acid-inducible gene-I (RIG-I) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) have been identified as important innate receptors to mount type I IFNs during RSV infection...
October 2019: PLoS Pathogens
https://read.qxmd.com/read/31050005/nasal-or-throat-sampling-is-adequate-for-the-detection-of-the-human-respiratory-syncytial-virus-in-children-with-acute-respiratory-infections
#25
JOURNAL ARTICLE
Van Hoan Nguyen, Fiona M Russell, David Ab Dance, Keoudomphone Vilivong, Souphatsone Phommachan, Chanthaphone Syladeth, Jana Lai, Ruth Lim, Melinda Morpeth, Mayfong Mayxay, Paul N Newton, Xavier De Lamballerie, Audrey Dubot-Pérès
Human respiratory syncytial virus (HRSV) is one of the most important causes of acute respiratory infections (ARI) in young children. HRSV diagnosis is based on the detection of the virus in respiratory specimens. Nasopharyngeal swabbing is considered the preferred method of sampling, although there is limited evidence of the superiority of nasopharyngeal swabs (NPS) over the less invasive nasal (NS) and throat (TS) swabs for virus detection by real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR)...
September 2019: Journal of Medical Virology
https://read.qxmd.com/read/30805760/assessing-the-performance-of-three-resveratrol-in-binding-with-sirt1-by-molecular-dynamics-simulation-and-mm-gbsa-methods-the-weakest-binding-of-resveratrol-3-to-sirt1-triggers-a-possibility-of-dissociation-from-its-binding-site
#26
JOURNAL ARTICLE
Han Chen, Yan Wang, Zheng Gao, Wen Yang, Jian Gao
SIRT1 is an NAD+-dependent deacetylase, whose activators have potential therapeutic applications in the age-related, metabolic, neurode-generative and cardiovascular diseases. Resveratrol (RSV) has been regarded as potent SIRT1 activator in the treatment of atherosclerosis and cardiovascular diseases. Moreover, the previous crystal structure of SIRT1 complex with RSV indicated that three RSV participated in the SIRT1 activation, namely RSV1 and RSV2 strengthened the interaction of SIRT1 to its substrate peptide and promoted the stimulation of SIRT1 activity, while RSV3 exhibited an auxiliary function...
April 2019: Journal of Computer-aided Molecular Design
https://read.qxmd.com/read/30558248/human-respiratory-syncytial-virus-ns-1-targets-trim25-to-suppress-rig-i-ubiquitination-and-subsequent-rig-i-mediated-antiviral-signaling
#27
JOURNAL ARTICLE
Junsu Ban, Na-Rae Lee, Noh-Jin Lee, Jong Kil Lee, Fu-Shi Quan, Kyung-Soo Inn
Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract disease. Retinoic acid-inducible gene-I (RIG-I) serves as an innate immune sensor and triggers antiviral responses upon recognizing viral infections including RSV. Since tripartite motif-containing protein 25 (TRIM25)-mediated K63-polyubiquitination is crucial for RIG-I activation, several viruses target initial RIG-I activation through ubiquitination. RSV NS1 and NS2 have been shown to interfere with RIG-I-mediated antiviral signaling...
December 14, 2018: Viruses
https://read.qxmd.com/read/30526144/resveratrol-protects-against-isoproterenol-induced-myocardial-infarction-in-rats-through-vegf-b-ampk-enos-no-signalling-pathway
#28
JOURNAL ARTICLE
Lifeng Feng, Jiling Ren, Yafei Li, Guifang Yang, Licheng Kang, Shengzheng Zhang, Changzhen Ma, Jing Li, Jie Liu, Liang Yang, Zhi Qi
According to our previous results, resveratrol (RSV, 3, 5, 4-trihydroxystilbene), a naturally polyphenolic phytoalexin, could attenuate myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B (VEGF-B) in isolated rat heart or H9c2 cells. However, the molecular mechanism remains unclear. In this study, we investigated the protective effect of RSV on myocardial infarction (MI) in rats and further explored the underlying signal pathway after VEGF-B. Rats received RSV or normal saline by intragastric administration for 7 consecutive days and followed by subcutaneously isoproterenol (ISO) or normal saline injections for another 2 days...
January 2019: Free Radical Research
https://read.qxmd.com/read/30037068/gene-expression-of-sirtuin-1-and-endogenous-secretory-receptor-for-advanced-glycation-end-products-in-healthy-and-slightly-overweight-subjects-after-caloric-restriction-and-resveratrol-administration
#29
RANDOMIZED CONTROLLED TRIAL
Alessandra Roggerio, Célia M Cassaro Strunz, Ana Paula Pacanaro, Dalila Pinheiro Leal, Julio Y Takada, Solange D Avakian, Antonio de Padua Mansur
Sirtuin-1 (Sirt-1) and an endogenous secretory receptor for an advanced glycation end product (esRAGE) are associated with vascular protection. The purpose of this study was to examine the effects of resveratrol (RSV) and caloric restriction (CR) on gene expression of Sirt-1 and esRAGE on serum levels of Sirt1 and esRAGE in healthy and slightly overweight subjects. The study included 48 healthy subjects randomized to 30 days of RSV (500 mg/day) or CR (1000 cal/day). Waist circumference ( p = 0.011), TC ( p = 0...
July 21, 2018: Nutrients
https://read.qxmd.com/read/29872390/resveratrol-prevents-cellular-and-behavioral-sensory-alterations-in-the-animal-model-of-autism-induced-by-valproic-acid
#30
JOURNAL ARTICLE
Mellanie Fontes-Dutra, Júlio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Gustavo Della-Flora Nunes, Mauro Mozael Hirsch, Guilherme Bauer-Negrini, Rudimar S Riesgo, Victorio Bambini-Júnior, Cecília Hedin-Pereira, Carmem Gottfried
Autism spectrum disorder (ASD) is characterized by impairments in both social communication and interaction and repetitive or stereotyped behaviors. Although its etiology remains unknown, genetic and environmental risk factors have been associated with this disorder, including the exposure to valproic acid (VPA) during pregnancy. Resveratrol (RSV) is an anti-inflammatory and antioxidant molecule known to prevent social impairments in the VPA animal model of autism. This study aimed to analyze the effects of prenatal exposure to VPA, as well as possible preventive effects of RSV, on sensory behavior, the localization of GABAergic parvalbumin (PV+ ) neurons in sensory brain regions and the expression of proteins of excitatory and inhibitory synapses...
2018: Frontiers in Synaptic Neuroscience
https://read.qxmd.com/read/29327810/nebulized-hypertonic-saline-in-infants-hospitalized-with-moderately-severe-bronchiolitis-due-to-rsv-infection-a-multicenter-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Yoshihiko Morikawa, Masaru Miura, Megumi Y Furuhata, Saeko Morino, Tae Omori, Masahiro Otsuka, Michiko Chiga, Toshimasa Obonai, Hiroshi Hataya, Tetsuji Kaneko, Kenji Ishikura, Masataka Honda, Yukihiro Hasegawa
INTRODUCTION: The efficacy of nebulized hypertonic saline (HS) therapy for shortening hospital length of stay (LOS) or improving bronchiolitic symptoms remains controversial. Most studies enrolled small numbers of subjects and did not consider the role of respiratory syncytial virus (RSV), the most common cause of acute bronchiolitis. Our aim was to evaluate the efficacy and safety of nebulized HS therapy for acute bronchiolitis due to RSV in moderately ill hospitalized infants. MATERIALS AND METHODS: This was an open-label, multicenter, randomized controlled trial comparing a nebulized HS treatment group with a normal saline (NS) group...
March 2018: Pediatric Pulmonology
https://read.qxmd.com/read/29110727/the-nonstructural-proteins-of-pneumoviruses-are-remarkably-distinct-in-substrate-diversity-and-specificity
#32
JOURNAL ARTICLE
Michael Ribaudo, Sailen Barik
BACKGROUND: Interferon (IFN) inhibits viruses by inducing several hundred cellular genes, aptly named 'interferon (IFN)-stimulated genes' (ISGs). The only two RNA viruses of the Pneumovirus genus of the Paramyxoviridae family, namely Respiratory Syncytial Virus (RSV) and Pneumonia Virus of Mice (PVM), each encode two nonstructural (NS) proteins that share no sequence similarity but yet suppress IFN. Since suppression of IFN underlies the ability of these viruses to replicate in the host cells, the mechanism of such suppression has become an important area of research...
November 6, 2017: Virology Journal
https://read.qxmd.com/read/28861397/modulation-of-host-immunity-by-human-respiratory-syncytial-virus-virulence-factors-a-synergic-inhibition-of-both-innate-and-adaptive-immunity
#33
REVIEW
Gisela Canedo-Marroquín, Orlando Acevedo-Acevedo, Emma Rey-Jurado, Juan M Saavedra, Margarita K Lay, Susan M Bueno, Claudia A Riedel, Alexis M Kalergis
The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide. Symptoms of hRSV infection include bronchiolitis and pneumonia. The lung pathology observed during hRSV infection is due in part to an exacerbated host immune response, characterized by immune cell infiltration to the lungs. HRSV is an enveloped virus, a member of the Pneumoviridae family, with a non-segmented genome and negative polarity-single RNA that contains 10 genes encoding for 11 proteins...
2017: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/28797008/resveratrol-attenuates-adriamycin-induced-focal-segmental-glomerulosclerosis-through-c3ar-c5ar-sphingosine-kinase-1-pathway
#34
JOURNAL ARTICLE
Guoyong Liu, Qiang Wang, Yan Shi, Xiaofei Peng, Hong Liu, Youming Peng, Liyu He
BACKGROUND/AIM: Focal segmental glomerulosclerosis (FSGS) typically presents with nephrotic range proteinuria, which could eventually develop into end-stage renal disease. Resveratrol (RSV) is a natural polyphenol compound, which has been reported to suppress inflammatory response and renal interstitial fibrosis. This study is aimed at evaluating the renoprotective effect of RSV treatment on adriamycin-induced FSGS. METHODS: In Balb/c mice, adriamycin nephropathy was induced by adriamycin (10 mg/kg body weight, diluted in normal saline) via a tail vein on day 0...
2017: Pharmacology
https://read.qxmd.com/read/28665409/structural-basis-for-human-respiratory-syncytial-virus-ns1-mediated-modulation-of-host-responses
#35
JOURNAL ARTICLE
Srirupa Chatterjee, Priya Luthra, Ekaterina Esaulova, Eugene Agapov, Benjamin C Yen, Dominika M Borek, Megan R Edwards, Anuradha Mittal, David S Jordan, Parameshwar Ramanan, Martin L Moore, Rohit V Pappu, Michael J Holtzman, Maxim N Artyomov, Christopher F Basler, Gaya K Amarasinghe, Daisy W Leung
Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatric, elderly and immune-compromised populations1,2 . A gap in our understanding of hRSV disease pathology is the interplay between virally encoded immune antagonists and host components that limit hRSV replication. hRSV encodes for non-structural (NS) proteins that are important immune antagonists3-6 ; however, the role of these proteins in viral pathogenesis is incompletely understood. Here, we report the crystal structure of hRSV NS1 protein, which suggests that NS1 is a structural paralogue of hRSV matrix (M) protein...
June 30, 2017: Nature Microbiology
https://read.qxmd.com/read/28368490/nasosorption-as-a-minimally-invasive-sampling-procedure-mucosal-viral-load-and-inflammation-in-primary-rsv-bronchiolitis
#36
JOURNAL ARTICLE
Ryan S Thwaites, Kazuhiro Ito, Jasmine M S Chingono, Matthew Coates, Hannah C Jarvis, Tanushree Tunstall, Lauren Anderson-Dring, Lindsey Cass, Garth Rapeport, Peter J Openshaw, Simon Nadel, Trevor T Hansel
Background: Existing respiratory mucosal sampling methods are flawed, particularly in a pediatric bronchiolitis setting. Methods: Twenty-four infants with bronchiolitis were recruited: 12 were respiratory syncytial virus (RSV)-positive, 12 were RSV-negative. Infants were sampled by nasosorption and nasopharyngeal aspiration (NPA). Results: Nasosorption was well tolerated and identified all RSV+ samples. RSV load measured by nasosorption (but not NPA) correlated with length of hospital stay (P = ...
April 15, 2017: Journal of Infectious Diseases
https://read.qxmd.com/read/28295570/agreement-among-4-sampling-methods-to-identify-respiratory-pathogens-in-dairy-calves-with-acute-bovine-respiratory-disease
#37
JOURNAL ARTICLE
D Doyle, B Credille, T W Lehenbauer, R Berghaus, S S Aly, J Champagne, P Blanchard, B Crossley, L Berghaus, S Cochran, A Woolums
BACKGROUND: Four sampling techniques commonly are used for antemortem identification of pathogens from cattle with bovine respiratory disease (BRD): the nasal swab (NS), guarded nasopharyngeal swab (NPS), bronchoalveolar lavage (BAL), and transtracheal wash (TTW). Agreement among these methods has not been well characterized. OBJECTIVE: To evaluate agreement among TTW and NS, NPS, or BAL for identification of viral and bacterial pathogens in dairy calves with BRD...
May 2017: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/27905537/unique-nonstructural-proteins-of-pneumonia-virus-of-mice-pvm-promote-degradation-of-interferon-ifn-pathway-components-and-ifn-stimulated-gene-proteins
#38
JOURNAL ARTICLE
Jayeeta Dhar, Sailen Barik
Pneumonia Virus of Mice (PVM) is the only virus that shares the Pneumovirus genus of the Paramyxoviridae family with Respiratory Syncytial Virus (RSV). A deadly mouse pathogen, PVM has the potential to serve as a robust animal model of RSV infection, since human RSV does not fully replicate the human pathology in mice. Like RSV, PVM also encodes two nonstructural proteins that have been implicated to suppress the IFN pathway, but surprisingly, they exhibit no sequence similarity with their RSV equivalents. The molecular mechanism of PVM NS function, therefore, remains unknown...
December 1, 2016: Scientific Reports
https://read.qxmd.com/read/27358012/respiratory-syncytial-virus-subtype-on1-na1-ba9-predominates-in-hospitalized-children-with-lower-respiratory-tract-infections
#39
JOURNAL ARTICLE
Ruyan Fan, Chuping Fan, Jian Zhang, Bo Wen, Yefei Lei, Chan Liu, Lijuan Chen, Wenpei Liu, Chuan Wang, Xiaowang Qu
Respiratory syncytial virus (RSV) infection is the leading cause of acute respiratory tract disease in children less than 5 years old. The aim of this study was to further elucidate the molecular properties and clinical characteristics of RSV infection. The study sample included 238 patients <5 years old who were hospitalized with clinical symptoms of upper or lower respiratory tract infection (URTI or LRTI) in the Pediatric Department at the First People's Hospital of Chenzhou, South China in 2014. We subjected nasopharyngeal aspirate (NPA) or nasal swab (NS) samples from the patients to indirect fluorescence assay screens...
February 2017: Journal of Medical Virology
https://read.qxmd.com/read/26876241/adverse-effects-of-a-10-day-course-of-ibuprofen-in-holstein-calves
#40
JOURNAL ARTICLE
P Walsh, F R Carvallo Chaigneau, M Anderson, N Behrens, H McEligot, B Gunnarson, L J Gershwin
Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for various conditions in cattle. Ibuprofen is an inexpensive short-acting NSAID and is readily available in liquid formulation for administration to bottle-fed calves. We compared the adverse effects of a 10-day course of ibuprofen and placebo in 16 five- to six-week-old Holstein bull calves that were being treated for experimentally induced bovine respiratory syncytial virus infection. Ibuprofen was administered as a liquid in milk replacer at 30 mg/kg divided three times daily...
October 2016: Journal of Veterinary Pharmacology and Therapeutics
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