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https://www.readbyqxmd.com/read/29345495/milton-frank-shore-1928-2017
#1
Robert Henley Woody
Presents an obituary for Milton Frank Shore, who passed away on January 6, 2017, due to pneumonia. During a long career, he was a tireless advocate for children, particularly those who were underserved. In addition, he made important contributions as an author, editor, and administrator. He was actively engaged in independent practice at the time of his death. Milt was one of the founders of American Psychological Association (APA) Division 37 (Child, Youth, and Family Services) and served as its president (1978-1979)...
January 2018: American Psychologist
https://www.readbyqxmd.com/read/29345007/aetiology-of-neonatal-conjunctivitis-evaluated-in-a-population-based-setting
#2
Minna Honkila, Marjo Renko, Irma Ikäheimo, Tytti Pokka, Matti Uhari, Terhi Tapiainen
AIM: Our aim was to study prospectively the aetiology of neonatal conjunctivitis in a population-based setting. METHODS: Altogether 173 neonates with clinical conjunctivitis aged on average 20 (SD 10) days were recruited from child welfare clinics in Oulu, Finland, in 2010-2015. Conjunctival specimens were collected from 167 neonates for multiplex polymerase chain reaction to detect 16 respiratory viruses, from 163 for polymerase chain reaction to detect Chlamydia trachomatis and Neisseria gonorrhoeae and from 160 for bacterial culture studies...
January 18, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29328418/microrna%C3%A2-3941-targets-igf2-to-control-lps%C3%A2-induced-acute-pneumonia-in-a549-cells
#3
Shinuan Fei, Lichun Cao, Liangzhi Pan
The present study aimed to investigate the potential roles and regulatory mechanism of microRNA (miR)-3941 in lipopolysaccharides (LPS)‑induced acute pneumonia. The expression of miR‑3941 in child patients with acute pneumonia was detected and A549 cells were treated with LPS to establish the cellular model of acute pneumonia. The effects of miR‑3941 in LPS‑induced cell injury were investigated by assessing cell viability, apoptosis and inflammation. In addition, the regulatory relationship between miR‑3941 and insulin‑like growth factor 2 (IGF2) was explored, as well as the association between miR‑3941 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/protein kinase B (PI3K/AKT) pathway...
December 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29302520/care-seeking-for-childhood-pneumonia-by-rural-and-poor-urban-communities-in-lucknow-a-community-based-cross-sectional-study
#4
Anurag Minz, Monika Agarwal, J V Singh, V K Singh
Context: Globally, around 16% of under-five children die due to pneumonia. Childhood pneumonia, if identified early is a readily treatable through low-cost antibiotics. Access to timely and appropriate care is a key action to control pneumonia. Aims: The aim of the study was to understand the caregiver's care-seeking behavior for the management of childhood pneumonia among rural and urban poor communities in Lucknow. Settings and Design: Rural areas and urban slums of Lucknow district, from September 2014 to August 2015...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29289941/azithromycin-to-prevent-post-discharge-morbidity-and-mortality-in-kenyan-children-a-protocol-for-a-randomised-double-blind-placebo-controlled-trial-the-toto-bora-trial
#5
Patricia B Pavlinac, Benson O Singa, Grace C John-Stewart, Barbra A Richardson, Rebecca L Brander, Christine J McGrath, Kirkby D Tickell, Mary Amondi, Doreen Rwigi, Joseph B Babigumira, Sam Kariuki, Ruth Nduati, Judd L Walson
INTRODUCTION: Child mortality due to infectious diseases remains unacceptably high in much of sub-Saharan Africa. Children who are hospitalised represent an accessible population at particularly high risk of death, both during and following hospitalisation. Hospital discharge may be a critical time point at which targeted use of antibiotics could reduce morbidity and mortality in high-risk children. METHODS AND ANALYSIS: In this randomised, double-blind, placebo-controlled trial (Toto Bora Trial), 1400 children aged 1-59 months discharged from hospitals in Western Kenya, in Kisii and Homa Bay, will be randomised to either a 5-day course of azithromycin or placebo to determine whether a short course of azithromycin reduces rates of rehospitalisation and/or death in the subsequent 6-month period...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29283957/early-tracheostomy-in-patients-with-traumatic-cervical-spinal-cord-injury-appears-safe-and-may-improve-outcomes
#6
Christopher Flanagan, Benjamin R Childs, Timothy A Moore, Heather A Vallier
STUDY DESIGN: Retrospective case series OBJECTIVE.: To characterize outcomes associated with tracheostomy timing following traumatic cervical spinal cord injury (CSCI). SUMMARY OF BACKGROUND DATA: The morbidity associated with cervical spine trauma is substantially increased in the setting of concomitant CSCI. Despite recent evidence, it remains uncertain if early tracheostomy following traumatic CSCI can improve outcomes. METHODS: From January 1, 2007, to December 31, 2015, retrospective chart review identified seventy (70) patients who presented to a single Level 1 trauma center with traumatic CSCI and received tracheostomy for management of respiratory compromise...
December 27, 2017: Spine
https://www.readbyqxmd.com/read/29278608/pneumonia-risk-stratification-scores-for-children-in-low-resource-settings-a-systematic-literature-review
#7
Katrina V Deardorff, Eric D McCollum, Amy Sarah Ginsburg
BACKGROUND: Pneumonia is the leading infectious cause of death among children less than five years of age. Predictive tools, commonly referred to as risk scores, can be employed to identify high-risk children early for targeted management to prevent adverse outcomes. This systematic review was conducted to identify pediatric pneumonia risk scores developed, validated, and implemented in low-resource settings. METHODS: We searched CAB Direct, Cochrane Reviews, Embase, PubMed, Scopus, and Web of Science for studies that developed formal risk scores to predict treatment failure or mortality among children less than five years of age diagnosed with a respiratory infection or pneumonia in low-resource settings...
December 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29241620/trends-in-and-projections-of-indicators-of-universal-health-coverage-in-bangladesh-1995-2030-a-bayesian-analysis-of-population-based-household-data
#8
Md Shafiur Rahman, Md Mizanur Rahman, Stuart Gilmour, Khin Thet Swe, Sarah Krull Abe, Kenji Shibuya
BACKGROUND: Many countries are implementing health system reforms to achieve universal health coverage (UHC) by 2030. To understand the progress towards UHC in Bangladesh, we estimated trends in indicators of the health service and of financial risk protection. We also estimated the probability of Bangladesh's achieving of UHC targets of 80% essential health-service coverage and 100% financial risk protection by 2030. METHODS: We estimated the coverage of UHC indicators-13 prevention indicators and four treatment indicators-from 19 nationally representative population-based household surveys done in Bangladesh from Jan 1, 1991, to Dec 31, 2014...
January 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29237494/adherence-to-the-integrated-management-of-childhood-illness-guidelines-in-namibia-kenya-tanzania-and-uganda-evidence-from-the-national-service-provision-assessment-surveys
#9
Carsten Krüger, Monika Heinzel-Gutenbrunner, Mohammed Ali
BACKGROUND: Integrated Management of Childhood Illness (IMCI) is regarded as a standard public health approach to lowering child mortality in developing countries. However, little is known about how health workers adhere to the guidelines at the national level in sub-Saharan African countries. METHODS: Data from the Service Provision Assessment surveys of Namibia (NA) (survey year: 2009), Kenya (KE) (2010), Tanzania (TZ) (2006) and Uganda (UG) (2007) were analysed for adherence to the IMCI guidelines by health workers...
December 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29228533/denosumab-treatment-of-severe-disuse-osteoporosis-in-a-boy-with-spinal-muscular-atrophy
#10
Stepan Kutilek
Denosumab is a fully human recombinant monoclonal antibody to the receptor activator of nuclear factor-κB ligand. Denosumab is used in the treatment of postmenopausal osteoporosis and cancer-related bone disorders. There are only very scarce data on denosumab treatment in children. 14-year-old boy with spinal muscular atrophy (SMA) and severe disuse osteoporosis (spinal bone mineral density L1-L4 BMD-6.2SD Z-score) and two prevalent fragility fractures was treated with denosumab. He received 60 mg  subcutaneous injection at the baseline and seven months later...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29227466/morbidity-and-mortality-of-a-cohort-of-peruvian-hiv-infected-children-2003-2012
#11
Amira N Baker, Angela M Bayer, Rolando M Viani, Lenka Kolevic, Myung-Shin Sim, Jaime G Deville
BACKGROUND: Data on pediatric HIV in Peru is limited. The National Institute of Child Health (Instituto Nacional de Salud del Niño: INSN) cares for the most HIV-infected children under age 18 in the country. We describe the outcomes of children seen at INSN's HIV clinic over the 10 years when antiretroviral therapy (ART) and prevention of mother-to-child transmission (PMTCT) interventions became available in 2004. METHODS: We conducted a retrospective review of INSN HIV clinic patients between 2003-2012...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227265/-peculiarities-of-the-analysis-of-the-level-of-proinflammatory-cytokins-in-the-community-acquired-pneumonia-in-children
#12
A Akhaeyva, D Zhupenova, T Kenzhetaeva, A Kysabekova, S Dzhabaeva
The high specific gravity in the structure of morbidity in children of all age groups, complicated course, determines the urgency of studying the clinical and diagnostic aspects of community-acquired pneumonia. In recent years, interest has been growing in the study of the child's cytokine status. A number of studies indicate that cytokines regulate the severity and duration of the inflammatory process. In this regard, the study of the possibility of determining the level of proinflammatory cytokines (IL-6 , TNF-α) is of great practical importance for assessing the prognosis of community-acquired pneumonia in children...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29219134/does-infant-feeding-method-influence-the-incidence-and-pattern-of-morbidities-among-human-immunodeficiency-virus-exposed-uninfected-nigerian-infants
#13
Olusoga Babatunde Ogunfowora, Tinuade Adetutu Ogunlesi, Abiodun Folashade Adekanmbi, Victor Ayodeji Ayeni
BACKGROUND: Human immunodeficiency virus (HIV)-exposed infants enrolled into the prevention of mother-to-child transmission of HIV program generally receive antiretroviral therapy (ARV), but the feeding methods differ based on several socioeconomic and cultural differences. OBJECTIVE: The objective of the study was to examine the incidence and pattern of morbidities among HIV-exposed uninfected (HEU) Nigerian infants and determine any relationship with infant feeding methods...
October 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29210350/rotavirus-vaccine-will-improve-child-survival-by-more-than-just-preventing-diarrhea-evidence-from-bangladesh
#14
Senjuti Saha, Mathuram Santosham, Manzoor Hussain, Robert E Black, Samir K Saha
Despite the high burden of rotavirus diarrhea, uptake of rotavirus vaccines in Asia remains low. This primarily stems from a perception of rotavirus as a non-life-threatening pathogen amidst a background of competing health priorities and limited resources. In the largest pediatric hospital of Bangladesh, where there is a fierce competition for beds, we found that between November 2015 and October 2016, 12% of 23,064 admissions were due to gastrointestinal infections, 54% of which were caused by rotavirus. One in four cases requiring hospitalization, or 5,879 cases, was refused because of unavailability of beds...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29207800/right-pulmonary-venous-atresia-a-rare-cause-for-recurrent-unilateral-pneumonia
#15
Prashant P Patil
Recurrent unilateral pneumonia poses a diagnostic dilemma for all paediatricians. Isolated pulmonary venous atresia is an uncommon entity, which presents with recurrent unilateral pulmonary infections, dyspnoea on exertion and haemoptysis. It is associated with significant mortality and morbidity. Owing to rarity of condition, there may be some difficulties in the diagnosis and therapy. Pulmonary angiography is the investigation of choice. However, the current multislice CT scanners may obviate the need for pulmonary angiography...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207760/epituberculosis-revisited-case-report-and-review
#16
Lavina Vishnu Mirchandani, Sindhu S Kamath, Jayalakshami Thelapurath Kutty, Aparna Iyer
Primary pulmonary tuberculosis can involve regional lymph nodes which may resolve spontaneously or on treatment; or they may enlarge causing extrinsic bronchial compression; or cause endobronchial inflammation and ulceration; or a node may erode through the bronchial wall with extrusion of caseous materials into the bronchial tree, causing focal or lobar pneumonia. This erosion is seen radiologically as hilar lymphadenopathy, with atelectasis and consolidation and described as "epituberculosis". It is more common in infants than older children...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29198820/resveratrol-improves-efficacy-of-oral-amoxicillin-against-childhood-fast-breathing-pneumonia-in-a-randomized-placebo-controlled-double-blind-clinical-trial
#17
Li Qiang, Yunfei Di, Zhilan Jiang, Juanjuan Xu
Childhood pneumonia has been considered as a major cause of child morbidity and mortality worldwide. We aimed to investigate the effect of resveratral in synergizing with oral amoxicillin to improve the treatment outcome of oral amoxicillin administration against childhood fast breathing pneumonia. 647 children diagnosed fast breathing pneumonia were recruited and randomized to receive oral amoxicillin plus either resveratrol (AX + RV) or placebo (AX + placebo). The primary outcome was defined as treatment failure up to day 3, while the secondary outcome was defined as treatment failure at day 6 and 12 upon follow up...
November 30, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29189676/disseminated-cryptococcosis-with-severe-increased-intracranial-pressure-complicated-with-cranial-nerve-palsy-in-a-child
#18
Bilge Aldemir Kocabaş, Mehmet Emin Parlak, Betil Özhak Baysan, Kamil Karaali, Ayşen Bingöl, Şenay Haspolat
Cryptococcosis is less common in children than adults but remains an important cause of pneumonia and meningoencephalitis in both immunocompromised and immunocompetent patients. Intracranial hypertension commonly complicates cryptococcal meningitis and may cause significant visual and neurological morbidity and mortality. Early and aggressive management of intracranial hypertension in accordance with established guidelines reduces the risk of long term complications and death. In this case report, we present a 12-year-old girl with cryptococcal meningitis, pneumonitis and dermatitis complicated with cranial nerve palsy and loss of vision...
November 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29189672/invasive-haemophilus-influenzae-serotype-a-infection-in-children-clinical-description-of-an-emerging-pathogen-alaska-2002-2014
#19
Ian D Plumb, Danielle Lecy, Rosalyn Singleton, Michael C Engel, Matthew Hirschfeld, James W Keck, Joseph Klejka, Karen M Rudolph, Thomas W Hennessy, Michael G Bruce
BACKGROUND: Invasive infections from Haemophilus influenzae serotype a (Hia) have been reported with increasing frequency, especially among indigenous populations. However there are limited population-based-studies of clinical severity. We studied invasive Hia infections in Alaska to determine clinical characteristics, mortality, and sequelae. METHODS: We defined an invasive Hia infection as the first detection of Hia from a usually sterile site in a child <10 years of age from Alaska...
November 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29183312/integrated-community-case-management-in-a-peri-urban-setting-a-qualitative-evaluation-in-wakiso-district-uganda
#20
Robin Altaras, Mark Montague, Kirstie Graham, Clare E Strachan, Laura Senyonjo, Rebecca King, Helen Counihan, Denis Mubiru, Karin Källander, Sylvia Meek, James Tibenderana
BACKGROUND: Integrated community case management (iCCM) strategies aim to reach poor communities by providing timely access to treatment for malaria, pneumonia and diarrhoea for children under 5 years of age. Community health workers, known as Village Health Teams (VHTs) in Uganda, have been shown to be effective in hard-to-reach, underserved areas, but there is little evidence to support iCCM as an appropriate strategy in non-rural contexts. This study aimed to inform future iCCM implementation by exploring caregiver and VHT member perceptions of the value and effectiveness of iCCM in peri-urban settings in Uganda...
November 28, 2017: BMC Health Services Research
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