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https://www.readbyqxmd.com/read/29332145/the-experiences-and-beliefs-of-older-people-in-scottish-very-sheltered-housing-about-using-multi-compartment-compliance-aids
#1
Derek Stewart, Kathrine Gibson Smith, Joan MacLeod, Alison Strath, Vibhu Paudyal, Katrina Forbes-McKay, Scott Cunningham, Katie MacLure
Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To describe experiences and beliefs surrounding very sheltered housing (VSH) residents' use of MCAs with emphasis on issues of personalisation, reablement, shared decision-making, independence and support...
January 13, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29332013/patterns-and-predictors-of-disclosure-of-hiv-positive-status-among-youth-living-with-hiv-in-ibadan-nigeria
#2
Adesola Olumide, Eme Owoaje
Background Information on disclosure of HIV status among youth is sparse in spite of the fact that they bear a significant burden of the HIV epidemic. Our objective was to determine the predictors of HIV disclosure among youth aged 18-35 years in Ibadan, Nigeria. Methods A cross-sectional study was conducted among youth with HIV attending two HIV support groups and one ARV clinic in Ibadan, Nigeria. Information was obtained with the aid of an interviewer-administered questionnaire. Descriptive and analytic statistics were conducted...
January 15, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29331129/perspective-structural-fluctuation-of-protein-and-anfinsen-s-thermodynamic-hypothesis
#3
Fumio Hirata, Masatake Sugita, Masasuke Yoshida, Kazuyuki Akasaka
The thermodynamics hypothesis, casually referred to as "Anfinsen's dogma," is described theoretically in terms of a concept of the structural fluctuation of protein or the first moment (average structure) and the second moment (variance and covariance) of the structural distribution. The new theoretical concept views the unfolding and refolding processes of protein as a shift of the structural distribution induced by a thermodynamic perturbation, with the variance-covariance matrix varying. Based on the theoretical concept, a method to characterize the mechanism of folding (or unfolding) is proposed...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#4
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330499/three-dimensional-physical-model-assisted-planning-and-navigation-for-laparoscopic-partial-nephrectomy-in-patients-with-endophytic-renal-tumors
#5
Gang Fan, Jun Li, Mingfeng Li, Mingji Ye, Xiaming Pei, Feiping Li, Shuai Zhu, Han Weiqin, Xiao Zhou, Yu Xie
Resection of completely endophytic renal tumors is a huge challenge for surgeons due to a lack of definite visual clues, especially in the laparoscopic approach. Three-dimensional (3D) kidney models, which can illustrate the clear relationship between renal masses and surrounding health tissues, were considered as reliable tools for understanding renal tumor characteristics in previous studies. We hypothesized that 3D kidney models can be used not only for planning but also for navigating laparoscopic partial nephrectomy (LPN) in patients with completely endophytic renal tumors...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329553/inhibitors-of-the-integrase-transportin-sr2-interaction-block-hiv-nuclear-import
#6
Jonas Demeulemeester, Jolien Blokken, Stéphanie De Houwer, Lieve Dirix, Hugo Klaassen, Arnaud Marchand, Patrick Chaltin, Frauke Christ, Zeger Debyser
BACKGROUND: Combination antiretroviral therapy efficiently suppresses HIV replication in infected patients, transforming HIV/AIDS into a chronic disease. Viral resistance does develop however, especially under suboptimal treatment conditions such as poor adherence. As a consequence, continued exploration of novel targets is paramount to identify novel antivirals that do not suffer from cross-resistance with existing drugs. One new promising class of targets are HIV protein-cofactor interactions...
January 12, 2018: Retrovirology
https://www.readbyqxmd.com/read/29329316/electroencephalography-power-and-coherence-changes-with-age-and-motor-skill-development-across-the-first-half-year-of-life
#7
Ran Xiao, Joanne Shida-Tokeshi, Douglas L Vanderbilt, Beth A Smith
Existing research in infants has correlated electroencephalography (EEG) measures of power and coherence to cognitive development and to locomotor experience, but only in infants older than 5 months of age. Our goal was to explore the relationship between EEG measures of power and coherence and motor skill development in younger infants who are developing reaching skill. Twenty-one infants with typical development between 38 and 203 days of age participated. Longitudinal EEG recording sessions were recorded in monthly increments, with 3-5 sessions acquired for 19 participants and 1 session for 2 participants, resulting in 71 sessions in total...
2018: PloS One
https://www.readbyqxmd.com/read/29329259/extreme-overvalued-beliefs-how-violent-extremist-beliefs-become-normalized
#8
Tahir Rahman
Extreme overvalued beliefs (EOB) are rigidly held, non-deusional beliefs that are the motive behind most acts of terrorism and mass shootings. EOBs are differentiated from delusions and obsessions. The concept of an overvalued idea was first described by Wernicke and later applied to terrorism by McHugh. Our group of forensic psychiatrists (Rahman, Resnick, Harry) refined the definition as an aid in the differential diagnosis seen in acts of violence. The form and content of EOBs is discussed as well as group effects, conformity, and obedience to authority...
January 12, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29327397/translating-international-hiv-treatment-guidelines-into-local-priorities-in-indonesia
#9
Noor Tromp, Rozar Prawiranegara, Adiatma Siregar, Rudi Wisaksana, Lucas Pinxten, Juul Pinxten, Arry Lesmana Putra, Deni Sunjaya Lesmana, Maarten Jansen, Jan Hontelez, Scott Maurits, Febrina Maharani, Leon Bijlmakers, Rob Baltussen
OBJECTIVE: International guidelines recommend countries to expand Antiretroviral therapy (ART) to all HIV-infected individuals and establish local-level priorities in relation to other treatment, prevention and mitigation interventions through fair processes. However, no practical guidance is provided for such priority setting processes. Evidence-informed deliberative processes (EDPs) fill this gap and combine stakeholder deliberation to incorporate relevant social values with rational decision-making informed by evidence on these values...
January 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29327375/impact-of-hiv-aids-epidemic-on-human-capital-development-in-west-africa
#10
Rasaki Stephen Dauda
West Africa occupies the third position with respect to the burden of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) globally, after Southern and East Africa. About 5 million adults and children are infected with the disease in the subregion, while HIV prevalence in the general population hovers around 2% and 5%. This paper attempts to investigate the impact of HIV/AIDS epidemic on human capital development in 11 West African countries over the period 1990 to 2011. The study used a dynamic panel data modeling approach, using first difference, difference generalized methods of moment, and system generalized methods of moment estimating techniques...
January 12, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29327183/bidirectional-jejunojejunal-anastomosis-prevents-early-small-bowel-obstruction-due-to-the-kinking-after-closure-of-the-mesenteric-defect-in-the-laparoscopic-roux-en-y-gastric-bypass
#11
Pierre Munier, Hefzi Alratrout, Iole Siciliano, Philippe Keller
BACKGROUND: The closure of the mesenteric defects (CMD) in Roux-en-Y gastric bypass (RYGB) reduces the risk of small bowel obstruction (SBO) due to internal hernia but might be associated with an increased risk of early SBO triggered by the jejunojejunal anastomosis (JJS) kinking. The aim of this study was to assess how enlarging the JJS with a bidirectional linear stapling can aid in avoiding the risk of early SBO by kinking. MATERIALS AND METHODS: This retrospective cohort study concerns 1327 patients who underwent RYGB with CMD between May 2007 and August 2016...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29325033/cancer-risk-in-older-people-living-with-human-immunodeficiency-virus-infection-in-the-united-states
#12
Parag Mahale, Eric A Engels, Anna E Coghill, Amy R Kahn, Meredith S Shiels
Background: Cancer risk is increased in people living with HIV (PLWH). Improved survival has led to an aging of PLWH. We evaluated the cancer risk in older PLWH (age ≥50 years). Methods: We included data from the HIV/AIDS Cancer Match Study (1996-2012) and evaluated risk of Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, and cervical, anal, lung, liver, oral cavity/pharyngeal, breast, prostate, and colon cancers in older PLWH compared to the general population by calculating the standardized incidence ratios (SIRs) and excess absolute risks (EARs)...
January 8, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29324943/knowledge-beliefs-and-attitudes-of-older-women-in-hiv-aids-prevention
#13
Milena Silva Costa, Maria Adelaide Silva Paredes Moreira, Antonia Oliveira Silva, Eliane de Sousa Leite, Luipa Michele Silva, Jéssica Barbosa Sampaio
OBJECTIVE: To analyze the knowledge, religious beliefs and the adoption of preventive measures against HIV/AIDS of non-Catholic elderly women. METHOD: A qualitative study, carried out in religious institutions of a municipality in the state of Ceará, Northeast Brazil, with 78 elderly women. Of these, 64 were evangelicals, seven spiritualists and seven Jehovah's Witnesses. A semi-structured interview script was used followed by thematic content analysis of participants' responses...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29324525/pharmacy-students-preparedness-to-communicate-with-mental-health-disorders-patients
#14
Claudia Chow, Hana Morrissey, Patrick Ball
The aim of this project was to explore whether fourth-year pharmacy students in England are prepared to communicate with mental health patients. Mental health problems are rising in the United Kingdom, affecting around one in four people. A questionnaire-based study measured the knowledge about and attitude toward mental health problems. Participants were fourth-year pharmacy students from two west midlands universities. More males than females correctly answered the "attitude towards mental health" questions...
January 10, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29324475/bilateral-cochlear-implants-maximizing-expected-outcomes
#15
Kate E Willis, Nathan J Blum, Stephanie A Waryasz, Marilyn Augustyn
Sonia is a 4 1/12-year-old girl with Waardenburg syndrome and bilateral sensorineural hearing loss who had bilateral cochlear implants at 2 7/12 years of age. She is referred to Developmental-Behavioral Pediatrics by her speech/language pathologist because of concerns that her language skills are not progressing as expected after the cochlear implant. At the time of the implant, she communicated using approximately 20 signs and 1 spoken word (mama). At the time of the evaluation (18 months after the implant) she had approximately 70 spoken words (English and Spanish) and innumerable signs that she used to communicate...
January 10, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29323978/nurse-led-epistaxis-management-within-the-emergency-department
#16
Navid Hakim, Sangha Mitra Mummadi, Karan Jolly, Julian Dawson, Adnan Darr
BACKGROUND: the incidence of epistaxis has increased secondary to increased life expectancy and morbidities. This study sought to assess the knowledge, practice and opinion relating to adequacy of training of advanced nurse practitioners (ANPs) and staff nurses (SNs) in the emergency department. METHODS: a national survey was distributed over an 8-week period; this included a 3-point scoring system based on the National Institute for Health and Care Excellence Clinical Knowledge Summaries guidance on epistaxis management to assess overall performance...
January 11, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29323885/unraveling-hidden-mg-mn-h-phase-relations-at-high-pressures-and-temperatures-by-in-situ-synchrotron-diffraction
#17
Kristina Spektor, Wilson A Crichton, Sumit Konar, Stanislav Filippov, Johan Klarbring, Sergei I Simak, Ulrich Häussermann
The Mg-Mn-H system was investigated by in situ high pressure studies of reaction mixtures MgH2-Mn-H2. The formation conditions of two complex hydrides with composition Mg3MnH7 were established. Previously known hexagonal Mg3MnH7 (h-Mg3MnH7) formed at pressures 1.5-2 GPa and temperatures between 480 and 500 °C, whereas an orthorhombic form (o-Mg3MnH7) was obtained at pressures above 5 GPa and temperatures above 600 °C. The crystal structures of the polymorphs feature octahedral [Mn(I)H6]5- complexes and interstitial H-...
January 11, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29323044/magnetic-resonance-imaging-guided-focused-ultrasound-to-increase-localized-blood-spinal-cord-barrier-permeability
#18
Allison H Payne, Gregory W Hawryluk, Yoshimi Anzai, Henrik Odéen, Megan A Ostlie, Ethan C Reichert, Amanda J Stump, Satoshi Minoshima, Donna J Cross
Spinal cord injury (SCI) affects thousands of people every year in the USA, and most patients are left with some permanent paralysis. Therapeutic options are limited and only modestly affect outcome. To address this issue, we used magnetic resonance imaging-guided focused ultrasound (MRgFUS) as a non-invasive approach to increase permeability in the blood-spinal cord barrier (BSCB). We hypothesize that localized, controlled sonoporation of the BSCB by MRgFUS will aid delivery of therapeutics to the injury. Here, we report our preliminary findings for the ability of MRgFUS to increase BSCB permeability in the thoracic spinal cord of a normal rat model...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29321048/danish-first-aid-books-compliance-with-the-new-evidence-based-non-resuscitative-first-aid-guidelines
#19
Theo Walther Jensen, Thea Palsgaard Møller, Søren Viereck, Jens Roland, Thomas Egesborg Pedersen, Freddy K Lippert
BACKGROUND: The European Resuscitation Council (ERC) released new guidelines on resuscitation in 2015. For the first time, the guidelines included a separate chapter on first aid for laypersons. We analysed the current major Danish national first aid books to identify potential inconsistencies between the current books and the new evidence-based first aid guidelines. METHODS: We identified first aid books from all the first aid courses offered by major Danish suppliers...
January 10, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29320890/chimeric-antigen-receptors-in-different-cell-types-new-vehicles-join-the-race
#20
Dennis C Harrer, Jan Dörrie, Niels Schaft
Adoptive cellular therapy has evolved into a powerful force in the battle against cancer, holding promise for curative responses in patients with advanced and refractory tumors. Autologous T cells, reprogrammed to target malignant cells via the expression of a chimeric antigen receptor (CAR) represent the frontrunner in this approach. Tremendous clinical regressions have been achieved using CAR-T cells against a variety of cancers both in numerous preclinical studies and in several clinical trials, most notably against ALL, and resulted in a very recent FDA-approval of the first CAR-T-cell therapy...
January 10, 2018: Human Gene Therapy
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