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https://www.readbyqxmd.com/read/29766272/blood-pressure-is-normal-but-is-the-heart
#1
Serkan Fazlı Çelik, Cemşit Karakurt, Yılmaz Tabel, Taner Elmas, Saim Yoloğlu
BACKGROUND: There is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. METHODS: Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography...
May 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29761655/fennel-induces-cytotoxic-effects-against-testicular-germ-cells-in-mice-evidences-for-suppressed-pre-implantation-embryo-development
#2
Aram Minas, Gholamreza Najafi, Ali Shalizar Jalali, Mazdak Razi
Foeniculum vulgare (FVE; fennel) is an aromatic plant belonging to Umbelliferae family, which is widely used in traditional societies because of its different pharmaceutical properties. To uncover the fennel-derived essential oil (FVEO)-induced effects on male reproductive potential, 24 mature male albino mice were divided into, control, 0.37, 0.75, and 1.5 mg kg-1 FVEO-received groups. Following 35 days, the animals were euthanized and the testicular tissue and sperm samples were collected. The histological alterations, tubular differentiation (TDI), spermiogenesis (SPI) indices, apoptosis ratio, and RNA damage of germinal cells were analyzed...
May 15, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29749652/evolution-of-echocardiography-in-subclinical-detection-of-cancer-therapy-related-cardiac-dysfunction
#3
REVIEW
Rohit Moudgil, Saamir Hassan, Nicolas Palaskas, Juan Lopez-Mattei, Jose Banchs, Syed Wamique Yusuf
Cancer therapies have resulted in increased survivorship in oncological patients. However, the benefits have been marred by the development of premature cardiovascular disease. The current definition outlines measurement of ejection fraction as a mean to diagnose cancer therapeutic-related cardiac dysfunction (CTRCD); however, up to 58% of the patients do not regain their cardiac function after the CTRCD diagnosis, despite therapeutic interventions. Therefore, there has been a growing interest in the markers for early myocardial changes (ie, changes with normal left ventricular ejection fraction [LVEF]) that may predict the development of subsequent left ventricular ejection fraction reduction or progression to heart failure...
May 11, 2018: Echocardiography
https://www.readbyqxmd.com/read/29741095/temporal-variability-of-cumulative-risk-assessment-on-phthalates-in-chinese-pregnant-women-repeated-measures-analysis
#4
Hui Gao, Bei-Bei Zhu, Xing-Yong Tao, Yuan-Duo Zhu, Xuguang Tao, Fang-Biao Tao
The assessment of combined effects of multiple phthalate exposures at low levels is a newly developed concept to avoid underestimating their actual cumulative health risk. A previous study included 3,455 Chinese pregnant women. Each of women provided up to three urine samples (in total of 9,529). This previous study characterized the concentrations of phthalate metabolites. In the present study, the data from 9,529 samples was re-analyzed to examine the cumulative risk assessment (CRA) with two models: (1) the creatinine-based and; (2) the volume-based...
May 9, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29735754/an-assessment-of-the-in-vitro-inhibition-of-cytochrome-p450-enzymes-cyp-udp-glucuronsyltransferases-ugt-and-transporters-by-phosphodiester-or-phosphorothioate-linked-oligonucleotides
#5
Faraz Kazmi, Phyllis Yerino, Chase McCoy, Andrew Parkinson, David B Buckley, Brian W Ogilvie
Oligonucleotides represent an expanding class of pharmacotherapeutics in development for various indications. Typically, oligonucleotides are developed with phosphorothioate linkages for the improvement of biological stability; however limited data are available on the potential of these molecules to cause drug-drug interactions (DDIs). In the present study, two non therapeutic oligonucleotides with either phosphodiester (PD-GP and PD-Ac) or phosphorothioate (PT-GP and PT-Ac) linkages were evaluated in vitro for their potential to inhibit P450s and UGTs in both human liver microsomes (HLM) and cryopreserved human hepatocytes (CHH) and to inhibit select transporters in expression systems...
May 7, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29729568/bioaccumulation-of-microcystin-congeners-in-soil-plant-system-and-human-health-risk-assessment-a-field-study-from-lake-taihu-region-of-china
#6
Qing Cao, Alan D Steinman, Xiang Wan, Liqiang Xie
A 120-day field study was carried out near Lake Taihu to evaluate the bioaccumulation of microcystin (MC) congeners in a soil-plant system, as well as to assess human health risk when consuming edible plants irrigated with MCs-contaminated water. Natural cyanobacteria bloom-containing lake water (lake water) and half-diluted natural cyanobacteria bloom-containing lake water with tap water (half-lake water) were used to irrigate lettuce and rice. An additional treatment involving fertilization with a cyanobacteria bloom was applied just to the lettuce experiment...
May 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29719657/comparative-study-of-semen-traits-and-histomorphometric-features-of-testes-of-broiler-breeder-males-with-different-phenotypic-traits
#7
Alireza Talebi, Manoochehr Alimehr, Mohammad Hossein Alavi, Gholamreza Najafi, Naeimeh Simaei
Fertility reduction due to sub-fertile males is a major concern in breeder flocks. Phenotypic traits of broiler breeder males and their relationships with fertility can be used as reliable indicators for identification and removal of sub-fertile males from the breeder flocks. This study was conducted to investigate semen traits (semen volume, sperm motility, sperm viability and sperm count) and testes histomorphometric features including tubule differentiation index (TDI), spermiation index (SPI), Sertoli cell index (SCI) and mitotic index (MI) of broiler breeder males with the same age but different phenotypic traits...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29717106/role-of-clusterin-progranulin-in-toluene-diisocyanate-induced-occupational-asthma
#8
Gil-Soon Choi, Hoang Kim Tu Trinh, Eun-Mi Yang, Young-Min Ye, Yoo Seob Shin, Seung-Hyun Kim, Hae-Sim Park
Toluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients with TDI-OA, asymptomatic exposed controls (AECs), and unexposed healthy normal controls (NCs)...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29716713/are-objective-measures-of-tricuspid-annular-motion-and-velocity-used-as-frequently-as-recommended-by-current-guidelines-a-pilot-study
#9
Angel López-Candales, Antonio J Sotolongo-Fernandez, Francisco López Menéndez, Maria D Candales
In this retrospective study 420 echocardiograms from a single center were reviewed showing that TAPSE was acquired in 66% while TA TDI s' signals were recorded in 98% of all echocardiograms. Based on these results greater efforts are required to standardize acquisition and reporting of objective measurements of RV function.
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29714450/obstructive-sleep-apnea-syndrome-is-associated-with-impaired-pulmonary-artery-distensibility-and-right-ventricular-systolic-dysfunction
#10
Süha Çetin, Mustafa Gökhan Vural, Hikmet Fırat, Ramazan Akdemir
Background/aim: We investigated whether obstructive sleep apnea syndrome (OSAS) has any impact on pulmonary artery distensibility (PAD) and right ventricular (RV) function. Materials and methods: Subjects were categorized according to apnea–hypopnea index (AHI) as follows: controls (n = 17 and AHI < 5), mild-to-moderate OSAS (n = 22 and AHI = 5–30), and severe OSAS (n = 29 and AHI > 30). All subjects underwent transthoracic echocardiography after polysomnography to assess PAD and RV function. PAD was recorded as M-Mode trace of the right pulmonary artery and was defined as (PAmax –PAmin/PAmin) × 100...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713156/indacaterol-glycopyrronium-reduces-the-risk-of-clinically-important-deterioration-after-direct-switch-from-baseline-therapies-in-patients-with-moderate-copd-a-post-hoc-analysis-of-the-crystal-study
#11
Timm Greulich, Konstantinos Kostikas, Mina Gaga, Maryam Aalamian-Mattheis, Nadine S Lossi, Francesco Patalano, Xavier Nunez, Veronica A Pagano, Robert Fogel, Claus F Vogelmeier, Andreas Clemens
Purpose: COPD is a progressive disease characterized by exacerbations and a decline in health status and lung function. Clinically important deterioration (CID) is a composite endpoint used to evaluate treatment efficacy. This analysis evaluated the impact of a direct switch to once-daily indacaterol/glycopyrronium 110/50 µg (IND/GLY) from previous monotherapy with a long-acting β2 -agonist (LABA) or long-acting muscarinic antagonist (LAMA) or with an LABA and an inhaled corticosteroid (LABA + ICS) on reducing CID...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29694547/echocardiographic-assessment-of-ventricular-function-in-young-patients-with-asthma
#12
Camilla Rayane De-Paula, Giselle Santos Magalhães, Nulma Souto Jentzsch, Camila Figueredo Botelho, Cleonice de Carvalho Coelho Mota, Tatiane Moisés Murça, Lidiana Fatima Correa Ramalho, Timothy C Tan, Carolina Andrade Braganca Capuruço, Maria da Gloria Rodrigues-Machado
BACKGROUND: Despite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined. OBJECTIVES: To compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls. METHODS: Eighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study...
March 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29676046/effectiveness-of-an-audiovisual-aid-on-the-knowledge-of-schoolteachers-regarding-emergency-management-of-dental-injuries
#13
Sabarinathan Niviethitha, Chanram Bhawarlal, Hemalatha Ramkumar, Senthil Dhakshanamoorthy, Hariharan Shanmugam
BACKGROUND/AIM: Traumatic Dental Injuries (TDI) occur frequently at school environment. Many studies have shown that teachers' knowledge on emergency management of TDI is inadequate. The aim of this study was to evaluate the knowledge level among schoolteachers in Chennai, India, regarding TDI using a questionnaire and to evaluate the effectiveness of a newly developed audiovisual aid (AV) as an educational tool by reapplying the questionnaire. METHODS: The questionnaire was distributed to 345 teachers in 15 randomly selected schools...
April 19, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29658810/early-changes-in-ediary-copd-symptoms-predict-clinically-relevant-treatment-response-at-12-weeks-analysis-from-the-crystal-study
#14
Konstantinos Kostikas, Maryam Aalamian-Mattheis, Veronica Anna Pagano, Xavier Nunez, Robert Fogel, Francesco Patalano, Andreas Clemens
Early detection of treatment response is important in the long-term treatment and management of patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated whether early improvement in symptoms, recorded in the first 7 or 14 days via an electronic diary (eDiary) compared with baseline, can predict clinically meaningful treatment responders at 12 weeks. CRYSTAL was a 12-week, randomized, open-label study that demonstrated the increased effectiveness of indacaterol/glycopyrronium (IND/GLY) or glycopyrronium (GLY), after a direct switch from on-going baseline therapies, in patients with symptomatic COPD and moderate airflow obstruction...
April 16, 2018: COPD
https://www.readbyqxmd.com/read/29656209/phosphorylation-of-low-density-lipoprotein-receptor-related-protein-6-is-involved-in-receptor-for-advanced-glycation-end-product-mediated-%C3%AE-catenin-stabilization-in-a-toluene-diisocyanate-induced-asthma-model
#15
Jing Xiong, Wenqu Zhao, Yun Lin, Lihong Yao, Guohua Huang, Changhui Yu, Hangming Dong, Guanhua Xiao, Haijin Zhao, Shaoxi Cai
BACKGROUND: We have previously demonstrated that the receptor for advanced glycation end products (RAGE)/β-catenin axis plays a vital role in regulating airway inflammation and airway remodeling in a toluene diisocyanate (TDI)-induced murine asthma model. However, the exact mechanism of β-catenin activation remains unclear. Given that phosphorylation of the low-density lipoprotein receptor-related protein 6 (Lrp6) is a key step in mediating β-catenin stabilization in canonical wnt/β-catenin signaling, we explored the possible relationship between RAGE and Lrp6 in regulating β-catenin stabilization in TDI-induced asthma...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29652856/temperature-effects-explain-continental-scale-distribution-of-cyanobacterial-toxins
#16
Evanthia Mantzouki, Miquel Lürling, Jutta Fastner, Lisette de Senerpont Domis, Elzbieta Wilk-Wo Zniak
Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale...
April 13, 2018: Toxins
https://www.readbyqxmd.com/read/29648694/safety-of-nifedipine-in-threatened-preterm-labor-investigation-by-three-dimensional-echocardiography
#17
Leonti Grin, Avishag Laish-Farkash, Simon Shenhav, Xavier Piltz, Liah Ganelin, Mark Rabinovich, Eyal Y Anteby, Chaim Yosefy
OBJECTIVE: To evaluate atrial and ventricular parameters using real time three-dimensional transthoracic echocardiography (RT3DTTE) in women treated with nifedipine in the early third trimester (III-T) of pregnancy. METHODS: A prospective single-subject design study in a university-affiliated hospital, where each participant served as her own control. We studied 25 pregnant women at a gestational age of 25-33 weeks with TPTL prior to vs 48 hours postnifedipine treatment...
April 12, 2018: Echocardiography
https://www.readbyqxmd.com/read/29627473/synthesis-and-characterization-of-chitosan-modified-polyurethane-bio-nanocomposites-with-biomedical-potential
#18
Muhammad Asif Javaid, Rasheed Ahmad Khera, Khalid Mahmood Zia, Kei Saito, Ijaz Ahmad Bhatti, Muhammad Asghar
A series of chitosan (CS) and montmorillonite (MMT) clay based polyurethane bio-nanocomposites were synthesized by step growth polymerization; reacting hydroxyl terminated polybutadiene (HTPB) and toluene diisocyanate (TDI) to improve thermal and antibacterial properties of polyurethane (PU). Five different PU samples were prepared by varying mole ratio of CS and 1,4-butane diol (from 0 to 2 mol). Structural studies of PUs through FTIR and1 H NMR spectroscopy confirmed the incorporation of CS into the polymer matrix...
April 5, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29622989/echocardiographic-predictors-of-atrial-fibrillation-after-mitral-valve-replacement
#19
REVIEW
Al-Shimaa Mohamed Sabry, Heba Abd El-Kader Mansour, Tarek Helmy Abo El-Azm, Shimaa Ahmed Mostafa, Basant Samy Zahid
Objectives: Detection of the echocardiographic predictors of post-operative atrial fibrillation in patients with rheumatic mitral valve disease undergoing mitral valve replacement. Methods: The study included 50 patients with rheumatic mitral valve disease undergoing mitral valve replacement. Preoperative assessment included standard two-dimensional echocardiography to assess LA diameter, volume, and emptying fraction, LV volume and ejection fraction. TDI derived velocity, strain of the left atrium and speckle tracking to assess left ventricular function then postoperative follow up for 1 month for occurrence of atrial fibrillation...
December 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29621577/six-months-exposure-to-a-real-life-mixture-of-13-chemicals-below-individual-noaels-induced-non-monotonic-sex-dependent-biochemical-and-redox-status-changes-in-rats
#20
Anca Oana Docea, Eliza Gofita, Marina Goumenou, Daniela Calina, Otilia Rogoveanu, Marius Varut, Cristian Olaru, Efthalia Kerasioti, Polyxeni Fountoucidou, Ioannis Taitzoglou, Ovidiu Zlatian, Valerii N Rakitskii, Antonio F Hernandez, Dimitrios Kouretas, Aristidis Tsatsakis
This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study...
April 2, 2018: Food and Chemical Toxicology
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