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https://www.readbyqxmd.com/read/28648919/myocardial-strain-rate-by-anatomic-doppler-spectrum-first-clinical-experience-using-retrospective-spectral-tissue-doppler-from-ultra-high-frame-rate-imaging
#1
Lars Christian Naterstad Lervik, Birger Brekke, Svein Arne Aase, Mai Tone Lønnebakken, Dordi Stensvåg, Brage H Amundsen, Hans Torp, Asbjorn Støylen
Strain rate imaging by tissue Doppler (TDI) is vulnerable to stationary reverberations and noise (clutter). Anatomic Doppler spectrum (ADS) presents retrospective spectral Doppler from ultra-high frame rate imaging (UFR-TDI) data for a region of interest, that is, ventricular wall or segment, at one time instance. This enables spectral assessment of strain rate (SR) without the influence of clutter. In this study, we assessed SR with ADS and conventional TDI in 20 patients with a recent myocardial infarction and 10 healthy volunteers...
June 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28644704/numerical-analysis-of-time-dependent-inhibition-kinetics-comparison-between-rat-liver-microsomes-and-rat-hepatocyte-data-for-mechanistic-model-fitting
#2
Chuong Pham, Swati Nagar, Ken Korzekwa
Time dependent inhibition (TDI) may confound drug interaction predictions. Recently, models were generated for an array of TDI kinetic schemes using numerical analysis of microsomal assays. Additionally, a distinct terminal inactivation step was identified for certain mechanism based inhibitors (MBI) following reversible metabolite intermediate complex (MIC) formation. Longer hepatocyte incubations potentially allow analysis of slow TDI and terminal inactivation. In the experiments presented here, we compared the quality of TDI parameterization by numerical analysis between hepatocyte and microsomal data...
June 23, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28640201/deoxynivalenol-biomarkers-in-the-urine-of-uk-vegetarians
#3
Liz Wells, Laura Hardie, Courtney Williams, Kay White, Yunru Liu, Barbara De Santis, Francesca Debegnach, Georgio Moretti, Stephanie Greetham, Carlo Brera, Maria Papageorgiou, Natalie J Thatcher, Alan Rigby, Stephen L Atkin, Thozhukat Sathyapalan
Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycotoxin. This study provides the levels of DON and de-epoxi Deoxynivalenol (DOM-1) in urine analysed by liquid chromatography-mass spectrometry (LC-MS) in UK vegetarians. Over two consecutive days, morning urine samples were collected from 32 vegetarians and 31 UK adult volunteers, and associated food consumption 24 h prior to the sample was recorded...
June 22, 2017: Toxins
https://www.readbyqxmd.com/read/28638852/olfactory-dysfunction-in-patients-with-primary-progressive-ms
#4
Felix A Schmidt, Matthew B Maas, Rohat Geran, Charlotte Schmidt, Hagen Kunte, Klemens Ruprecht, Friedemann Paul, Önder Göktas, Lutz Harms
OBJECTIVE: We tested the hypothesis that olfactory function is more impaired in patients with primary progressive MS (PPMS) than that in relapsing-remitting MS (RRMS). METHODS: Standardized olfactory testing was performed in 32 patients with PPMS, 32 patients with RRMS, and 32 healthy controls (HCs). Patients with olfactory dysfunction due to an alternative primary etiology were excluded. The validated olfactory testing method yielded individual scores for olfactory threshold, odor discrimination, and odor identification, along with a composite Threshold Discrimination Identification (TDI) score...
July 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28636515/a-brief-period-of-intensive-cardiac-rehabilitation-improves-global-longitudinal-strain-and-diastolic-function-after-a-first-uncomplicated-myocardial-infarction
#5
Gabriella Malfatto, Miriam Revera, Giovanna Branzi, Francesca Ciambellotti, Alessia Giglio, Simonetta Blengino, Matteo Oldani, Camilla Facchini, Gianfranco Parati, Mario Facchini
Objectives In patients with abnormal left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), cardiac rehabilitation with physical training prevents cardiac remodelling. To define the role of rehabilitation in the recovery of ventricular function in less severe cases, we studied its effects on more refined indexes of left ventricular function in uncomplicated, low-risk patients. Methods and results Fifty-five patients underwent percutaneous coronary revascularization after uncomplicated first AMI...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28635219/-olfactory-function-in-children-with-adenoid-hypertrophy-who-underwent-adenotonsillectomy-during-pre-and-post-operative-period
#6
H G Pan, H Yang, G W Chen, L Li, Z B Wu, J M Wang
Objective: To assess the olfactory function in children with adenoid hypertrophy and investigate the changes of both olfactory function and appetite in children with adenoid hypertrophy before and after adenoidectomy. Methods: Forty-four children with adenoid hypertrophy admitted for adenoidectomy, aged 7-12 years, mean age (10.0±2.0) years were tested by Sniffin' Sticks test and visual analog scale(VAS) of the children's appetite preoperatively between March and August 2015.In a appointment 6 months after operation, all of them returned and were tested again...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28632156/image-mosaicking-approach-for-a-double-camera-system-in-the-gaofen2-optical-remote-sensing-satellite-based-on-the-big-virtual-camera
#7
Yufeng Cheng, Shuying Jin, Mi Wang, Ying Zhu, Zhipeng Dong
The linear array push broom imaging mode is widely used for high resolution optical satellites (HROS). Using double-cameras attached by a high-rigidity support along with push broom imaging is one method to enlarge the field of view while ensuring high resolution. High accuracy image mosaicking is the key factor of the geometrical quality of complete stitched satellite imagery. This paper proposes a high accuracy image mosaicking approach based on the big virtual camera (BVC) in the double-camera system on the GaoFen2 optical remote sensing satellite (GF2)...
June 20, 2017: Sensors
https://www.readbyqxmd.com/read/28631387/umeclidinium-bromide-versus-placebo-for-people-with-chronic-obstructive-pulmonary-disease-copd
#8
REVIEW
Han Ni, Aung Htet, Soe Moe
BACKGROUND: People with chronic obstructive pulmonary disease (COPD) have poor quality of life, reduced survival, and accelerated decline in lung function, especially associated with acute exacerbations, leading to high healthcare costs. Long-acting bronchodilators are the mainstay of treatment for symptomatic improvement, and umeclidinium is one of the new long-acting muscarinic antagonists approved for treatment of patients with stable COPD. OBJECTIVES: To assess the efficacy and safety of umeclidinium bromide versus placebo for people with stable COPD...
June 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28616561/left-atrial-appendage-function-assessment-and-thrombus-identification
#9
Jacek Kurzawski, Agnieszka Janion-Sadowska, Marcin Sadowski
BACKGROUND: The diagnosis of thrombus in the left atrium in patients with persistent atrial fibrillation (AF) and may be inconsistent because of variability in thrombus morphology. In some cases it is challenging and requires unusual approach. New Doppler-derived methods might be helpful to identify such thrombi. We evaluated quantitative differences in mechanical function of the left atrial appendage (LAA) basal segments using tissue Doppler imaging (TDI)and speckle tracking echocardiography (STE) in patients with non-valvular AF with and without LAA thrombus and compared them with SR patients...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28602893/daily-uptake-of-mycotoxins-tdi-might-not-be-protective-for-nursed-infants
#10
G H Degen, F Partosch, K Muñoz, U Gundert-Remy
Exclusive breast feeding is recommended by international bodies for the first six months of life. Because of the presence of contaminants, breast feeding might lead to toxicologically relevant exposure of the nursed child. Exposure towards mycotoxins is of specific interest because of their widespread occurrence in food and of their toxicological profile. We calculated the relationship between maternal intake at the level of the existing TDIs and the exposure in the nursed infants of several mycotoxins to evaluate whether maternal exposure at the TDI is also safe for the nursed infant...
June 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28592559/time-dependent-inhibition-of-phd2
#11
Isabelle Tcholakov, Charles E Grimshaw, Lihong Shi, Andre Kiryanov, Sean T Murphy, Christopher J Larson, Artur Plonowski, Jacques Ermolieff
Prolyl Hydroxylases (PHDs) down-regulate the level of hypoxia-inducible factors (HIFs) by hydroxylating key proline residues which triggers the degradation of the protein and affect the cell and its ability to respond to hypoxic stress. Several small molecule PHD inhibitors are now in various preclinical and clinical stages for the treatment of anemia. This study provides a detail kinetic analysis for some of these inhibitors. The data generated in this study suggest that these compounds are reversible and compete directly with the co-substrate, 2-oxoglutarate (2-OG) for binding at the enzyme active site...
June 7, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28586098/diastolic-dysfunction-of-hypertrophic-cardiomyopathy-genotype-positive-subjects-without-hypertrophy-is-detected-by-tissue-doppler-imaging-a-systematic-review-and-meta-analysis
#12
Wen Liu, Dandan Sun, Jun Yang
OBJECTIVES: To evaluate whether diastolic dysfunction derived by tissue Doppler imaging (TDI) would be an earlier manifestation in genotype-positive hypertrophic cardiomyopathy (HCM) subjects without left ventricular hypertrophy (LVH). METHODS: We systematically searched Pubmed, Medline, and Web of Science with an upper date limit of June 2016 for studies evaluating the diastolic function of HCM genotype-positive subjects without hypertrophy (G+/LVH-). Based on the inclusion criteria, eligible studies were selected...
June 6, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28583010/occurrence-and-incidence-of-18-per-and-polyfluoroalkyl-compounds-in-edible-oils-commonly-consumed-in-guiyang-china
#13
Hongbo Yang, Guihong Li, Zhu Rao, Feng Guo, Zhanbin Li, Feng Xie, Hong Tan
A systematic examination was conducted for the first time of a wide carbon-chain range of per- and polyfluoroalkyl compounds (PFASs) in eighty-three samples of edible vegetable and animal oils from Guiyang, China. The occurrence and levels of 18 PFASs in 7 types of edible oil were analyzed. Analytes were determined based on a simplified, sensitive and reliable solvent extraction and liquid chromatography tandem mass spectrometry method. Ten target PFASs were found and the most frequently detected compounds with maximum concentration were PFOS (88%, 1...
June 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28577669/diastolic-dysfunction-revisited-a-new-feasible-and-unambiguous-echocardiographic-classification-predicts-major-cardiovascular-events
#14
Niklas Dyrby Johansen, Tor Biering-Sørensen, Jan Skov Jensen, Rasmus Mogelvang
BACKGROUND: Echocardiographic classification of DDF has been widely discussed. The aim of this study was to investigate the independent prognostic value of established echocardiographic measures in a community-based population and create a new classification of DDF. METHODS: Within the Copenhagen City Heart Study, a prospective, community-based study, 1851 participants were examined by echocardiography including Tissue Doppler Imaging (TDI) in 2001 to 2003 and followed with regard to MACE (median, 10...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28577664/feasibility-of-exercise-stress-echocardiography-and-myocardial-response-in-patients-with-repaired-congenital-heart-disease
#15
Babar S Hasan, Fatima I Lunze, Najveen Alvi, Keri M Shafer, Jonathan Rhodes
BACKGROUND: Exercise stress echocardiography (ESE) can unmask ventricular dysfunction in asymptomatic patients with congenital heart disease (CHD), but its acquisition and interpretation is often challenging, and the method has not been validated in CHD. This study aimed to evaluate the feasibility of ESE using Doppler imaging and to assess myocardial response to exercise in patients with biventricular (BiV) and univentricular (UniV) circulation after CHD repair. METHODS: In this single-center prospective study, we recruited 55 participants (17 females), median age 14 years (8-22 years)...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28573516/-persistent-organic-contaminants-in-food-exposure-hazard-potential-and-health-assessment
#16
REVIEW
Ulrike Pabel, Thorsten Buhrke, Klaus Abraham, Thilo Nölke, Matthias Gehling, Alfonso Lampen, Monika Lahrssen-Wiederholt, Reiner Wittkowski
Environmental emissions of organic contaminants are caused by man-made and natural combustion processes, industrial production facilities, and the release from products. Food represents the main source of human exposure for some of these compounds. This is the case for three groups of persistent organic contaminants: (1) per- and polyfluoroalkyl substances (PFAS), (2) polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and for (3) polycyclic aromatic hydrocarbons (PAHs)...
June 1, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28571651/timing-therapeutic-donor-inseminations-in-natural-cycles-human-chorionic-gonadotrophin-administration-versus-urinary-lh-monitoring
#17
Hady El Hachem, Roland Antaki, Camille Sylvestre, Louise Lapensée, Guillaume Legendre, Pierre Emmanuel Bouet
This cohort study assessed whether timing therapeutic donor sperm inseminations (TDI) in natural cycles (NC) using ultrasound monitoring and ovulation trigger with human chorionic gonadotrophin (US/HCG) improves cumulative live birth rates (LBR) compared with detection of LH surge with urinary kits (u-LH). It included 232 normo-ovulatory women aged ≤40 years, undergoing 538 TDI in NC between 2011 and 2014. In the u-LH group (113 women, 267 cycles), TDI was performed the day following a positive test. In the US/HCG group (119 women, 271 cycles), ovulation was triggered with HCG when a follicle ≥17 mm was noted, and TDI performed 36 h later...
May 18, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28569600/the-associations-among-co-morbidity-cardiac-geometries-and-mechanics-in-hospitalized-heart-failure-with-or-without-preserved-ejection-fraction
#18
Chi-In Lo, Yau-Huei Lai, Sheng-Nan Chang, Jen-Yuan Kuo, Ya-Ching Hsieh, Bernard E Bulwer, Chung-Lieh Hung, Hung-I Yeh
BACKGROUND: The associations among chronic health conditions, ventricular geometric alterations or cardiac contractile mechanics in different phenotypes heart failure (HF) remain largely unexplored. METHODS: We studied 438 consecutive hospitalized patients (mean age: 64.9 ± 16.6 years, 52.5% female) with or without clinical evidence of HF. We examined the associations among clinical co-morbidities, LV geometries and systolic mechanics in terms of global myocardial strains...
June 1, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28569076/clinical-impact-of-blood-glucose-monitoring-accuracy-an-in-silico-study
#19
Enrique Campos-Náñez, Kurt Fortwaengler, Marc D Breton
BACKGROUND: Patients with diabetes rely on blood glucose (BG) monitoring devices to manage their condition. As some self-monitoring devices are becoming more and more accurate, it becomes critical to understand the relationship between system accuracy and clinical outcomes, and the potential benefits of analytical accuracy. METHODS: We conducted a 30-day in-silico study in type 1 diabetes mellitus (T1DM) patients using continuous subcutaneous insulin infusion (CSII) therapy and a variety of BG meters, using the FDA-approved University of Virginia (UVA)/Padova Type 1 Simulator...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28566230/efficacy-and-safety-of-indacaterol-in-patients-with-chronic-obstructive-pulmonary-disease-aged-over-65-years-a-pooled-analysis
#20
Pierre-Olivier Girodet, Jean-Yves Jasnot, Vincent Le Gros, Laurent Decuypère, Weihua Cao, Gilles Devouassoux
BACKGROUND: Although the prevalence of chronic obstructive pulmonary disease (COPD) increases with age, no specific therapeutic approaches are available till date for the elderly population. AIM: To assess the efficacy and safety of once-daily indacaterol 150 and 300 μg in elderly patients with moderate to severe COPD. METHODS: Data were pooled from 11 randomized, double-blind, placebo- and active-controlled studies (8445 patients with COPD)...
May 24, 2017: Respiratory Medicine
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