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https://www.readbyqxmd.com/read/29329020/a-novel-mouse-model-of-atopic-dermatitis-that-is-t-helper-2-th2-polarized-by-an-epicutaneous-allergen
#1
Hyun Jung Park, Wahn Soo Choi, Won Young Lee, Youngsok Choi, Chankyu Park, Jin Hoi Kim, Kwon Ho Hong, Hyuk Song
The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensitized with one of four chemical allergens - toluene diisocyanate (TDI), hexamethylene diisocyanate (HDI), trimellitic anhydride (TMA), or 2,4-dinitrochlorobenzene (DNCB) - for 3 weeks. Based on results of experiment 1, immunological features were compared between TMA-sensitized BALB/c mice and NC/Nga mice, after exposure to mite extracts, harmful chemicals and detergents in experiment 2...
December 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29326503/impact-of-dental-trauma-on-quality-of-life-among-11-14-years-schoolchildren
#2
Ibrahim Hassan El-Kalla, Hanaa Mahmoud Shalan, Rabaa Abo Bakr
Background: Traumatic injuries are common dental problems in pediatric dentistry that may influence the children's quality of life. Aim: the aim of this study is to assess the impact of traumatic dental injuries (TDI) and oral health-related quality of life (OHRQoL) among Egyptian schoolchildren aged 11-14 years. Materials and Methods: A cross-sectional study was carried out involving a sample of 11700 schoolchildren from public and private schools of Mansoura city, Egypt...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29324080/risk-assessment-of-dietary-exposure-to-perchlorate-for-the-austrian-population
#3
Katharina Vejdovszky, Roland Grossgut, Hermann Unterluggauer, Norbert Inreiter, Johann Steinwider
Perchlorate is frequently found as contaminant in a diversity of food. Based on analytical data of perchlorate occurrence in food products from the Austrian market, this study calculated dietary perchlorate exposure of the Austrian population for the three age classes of adults, children and infants. Furthermore, a detailed risk assessment was conducted based on the tolerable daily intake (TDI) of 0.3 µg/kg bodyweight/day, established by the European Food Safety Authority in 2014. Calculations of a scenario of average food consumption did not indicate elevated health risks by dietary perchlorate uptake...
January 11, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29321922/longitudinal-pharmacoepidemiological-and-health-services-research-for-substance-users-in-treatment-protocol-of-the-belgian-tdi-ima-linkage
#4
Luk Van Baelen, Karin De Ridder, Jérôme Antoine, Lies Gremeaux
Background: Not much is known about the health seeking behavior of people with substance use disorders before they enter specialized treatment and afterwards. This paper explains in detail the protocol that has been followed to establish the Belgian TDI-IMA-database, which is linking two separate databases: the Treatment Demand Indicator (TDI) and the database of the Intermutualistic Agency (IMA). The Treatment Demand Indicator is measuring incidence of people with substance use disorders entering drug treatment...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29313286/once-daily-triple-therapy-in-patients-with-copd-patient-reported-symptoms-and-quality-of-life
#5
Maggie Tabberer, David A Lomas, Ruby Birk, Noushin Brealey, Chang-Qing Zhu, Steve Pascoe, Nicholas Locantore, David A Lipson
INTRODUCTION: Directly recorded patient experience of symptoms and health-related quality of life (HRQoL) can complement lung function and exacerbation rate data in chronic obstructive pulmonary disease (COPD) clinical studies. The FULFIL study recorded daily symptoms and activity limitation together with additional patient-reported outcomes of dyspnea and HRQoL, as part of the prespecified analyses. FULFIL co-primary endpoint data have been previously reported. METHODS: FULFIL was a phase III, 24-week, randomized, double-blind, double-dummy, multicenter study comparing once-daily single inhaler triple therapy [fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI)] 100 µg/62...
January 8, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29306590/new-definition-criteria-of-myocardial-dysfunction-in-patients-with-liver-cirrhosis-a-speckle-tracking-and-tissue-doppler-imaging-study
#6
Roxana Cristina Rimbaş, Sorina Mihăilă Baldea, Ruxandra Drăgoi Galrinho Antunes Guerra, Simona Ionela Visoiu, Mihai Rimbaş, Corina Silvia Pop, Dragoş Vinereanu
There are no clear recommendations regarding cirrhotic cardiomyopathy (CC) evaluation in patients with pre-transplant liver cirrhosis. The roles of new methods, tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) in the diagnosis and prognosis of cirrhotic cardiomyopathy remain controversial. We investigated the utility of TDI/STE parameters in cirrhotic cardiomyopathy diagnosis and also in predicting mortality in patients with liver cirrhosis. Left/right ventricular function was studied using conventional TDI (velocities) and STE (strain/strain rate)...
January 3, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29300883/left-atrial-function-to-identify-patients-with-atrial-fibrillation-at-high-risk-of-stroke-new-insights-from-a-large-registry
#7
Melissa Leung, Philippe J van Rosendael, Rachid Abou, Nina Ajmone Marsan, Dominic Y Leung, Victoria Delgado, Jeroen J Bax
Aims: Atrial fibrillation (AF) is an independent risk factor for ischaemic stroke. The CHA2DS2-VASc is the most widely used risk stratification model; however, echocardiographic refinement may be useful, particularly in low risk AF patients. The present study examined the association between advanced echocardiographic parameters and ischaemic stroke, independent of CHA2DS2-VASc score. Methods and results: One thousand, three hundred and sixty-one patients (mean age 65±12 years, 74% males) with first diagnosis of AF and baseline transthoracic echocardiogram were followed by chart review for the occurrence of stroke over a mean of 7...
December 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29290381/a-comparison-of-the-strain-and-tissue-doppler-based-indices-as-echocardiographic-correlates-of-the-left-ventricular-filling-pressures
#8
Rohan Magoon, Vishwas Malik, Arindam Choudhury, Sandeep Chauhan, Milind P Hote, Sivasubramanian Ramakrishnan, Vishwajeet Singh
OBJECTIVES: Diastolic strain and strain rate, combined with E (peak transmitral velocity), have been proposed as novel noninvasive predictors of left ventricle (LV) filling pressures, avoiding angulation errors inherent to tissue Doppler indices (TDI). The primary objective was to study the correlation of strain-based indices (SBI) and TDI with pulmonary artery catheter-derived LV end-diastolic pressures (LVEDP). The secondary aim was to determine appropriate cut-off of indices to predict LVEDP ≥15 mmHg...
November 28, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29289289/airborne-pcdd-fs-in-two-e-waste-recycling-regions-after-stricter-environmental-regulations
#9
Manwen Zhang, Guixian Feng, Wenhua Yin, Bing Xie, Mingzhong Ren, Zhencheng Xu, Sukun Zhang, Zongwei Cai
Since the 2010s, the authorities of Guangdong province and local governments have enhanced law enforcement and environmental regulations to abolish open burning, acid washing, and other uncontrolled e-waste recycling activities. In this study, ambient air and indoor dust near different kinds of e-waste recycling processes were collected in Guiyu and Qingyuan to investigate the pollution status of particles and polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) after stricter environmental regulations. PM2...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29282169/maternal-stress-and-behavioral-and-clinical-factors-associated-with-dental-trauma-in-schoolchildren
#10
Clarissa Lopes Drumond, Ednele Primo Miranda, Débora Souto Souza, Leandro Silva Marques, Maria Letícia Ramos-Jorge, Joana Ramos-Jorge
PURPOSE: The purpose of this study was to evaluate associations between traumatic dental injury (TDI) and maternal stress and demographic, behavioral, and clinical characteristics of schoolchildren. METHODS: A cross-sectional investigation was conducted involving 396 eight- to 11- year-old schoolchildren in the city of Diamantina, Minas Gerais, Brazil. Maternal stress and demographic and behavioral (breastfeeding and non-nutritive sucking habits) factors were evaluated using a questionnaire...
September 15, 2017: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/29278007/what-do-polish-parents-know-about-dental-trauma-and-its-management-in-children-s-treatment-a-questionnaire-study
#11
Magdalena Świątkowska, Joanna Kargol, Anna Turska-Szybka, Dorota Olczak-Kowalczyk
OBJECTIVES: To evaluate the knowledge of Polish parents concerning traumatic dental injuries (TDIs) and their management in children and to assess the influence of TDI experience on parents' knowledge. METHODS: A questionnaire study conducted from May 2014 to February 2015 involved 741 randomly selected individual parents of children aged 1-17 receiving treatment at the Department of Pediatric Dentistry at the Medical University of Warsaw. The questionnaire consisted of 28 questions concerning TDI management...
December 26, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29277690/correlations-between-fev1-and-patient-reported-outcomes-a-pooled-analysis-of-23-clinical-trials-in-patients-with-chronic-obstructive-pulmonary-disease
#12
REVIEW
James F Donohue, Paul W Jones, Christian Bartels, Jessica Marvel, Peter D'Andrea, Donald Banerji, David G Morris, Francesco Patalano, Robert Fogel
BACKGROUND: In clinical trials of inhaled bronchodilators, chronic obstructive pulmonary disease (COPD) guidelines recommend that patient-reported outcomes (PROs) are assessed alongside lung function. How these endpoints are related is unclear. METHODS: Pooled longitudinal data from 23 randomised controlled COPD studies were analyzed (N = 23,213). Treatments included long-acting β2 agonists, long-acting muscarinic antagonists (LABAs or LAMAs) and the LABA/LAMA combination QVA149...
December 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29274131/roles-of-p21-p53-cyclin-d1-cdk-4-estrogen-receptor-%C3%AE-in-aflatoxin-b1-induced-cytotoxicity-in-testicular-tissue-of-mice
#13
Toraj Zamir-Nasta, Mazdak Razi, Hasanzadeh Shapour, Hassan Malekinejad
This study was done in order to investigate time-dependent effect of AFB1 on expression of genes involving in cell cycle check point machinery at G, S, and M phases. For this purpose, 24 mature male Swiss albino mice were randomly divided into control and test groups. The animals in test group subdivided into three groups, which received the AFB1 at a daily dose of 20 µg/kg body weight, through intraperitoneal (i.p.) route, for 7, 14, and 21 days. The p21, p53, cyclin D1, CDK4, and ERα expressions at both mRNA and protein level were analyzed by using reverse transcription PCR (RT-PCR) and immunohistochemistry, respectively...
December 23, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29262403/sacubitril-valsartan-in-an-elderly-patient-with-heart-failure-a-case-report
#14
Matteo Cameli, Maria Concetta Pastore, Antonio Pagliaro, Cristina Di Tommaso, Rosanna Reccia, Valeria Curci, Giulia Elena Mandoli, Sergio Mondillo
Sacubitril/valsartan has recently been approved for the treatment of heart failure with reduced ejection fraction. Given its recent introduction in the armamentarium for the treatment of heart failure (HF), "field-practice" evidence is required to deepen the clinical management of sacubitril/valsartan therapy. We report a relevant case of an elderly patient who achieved major clinical benefits after only 3 months of sacubitril/valsartan therapy. Importantly, in our assessment, we employed speckle tracking echocardiography (STE), a recent echocardiography technique that is non-Doppler and not angle dependent, which analyzes deformations of heart chambers from standard images and allows a fast, reliable, and reproducible assessment of heart function...
2017: Cardiology
https://www.readbyqxmd.com/read/29247318/super-resolution-track-density-imaging-reveals-fine-anatomical-features-in-tree-shrew-primary-visual-cortex-and-hippocampus
#15
Jian-Kun Dai, Shu-Xia Wang, Dai Shan, Hai-Chen Niu, Hao Lei
Diffusion-weighted magnetic resonance imaging (dMRI) is widely used to study white and gray matter (GM) micro-organization and structural connectivity in the brain. Super-resolution track-density imaging (TDI) is an image reconstruction method for dMRI data, which is capable of providing spatial resolution beyond the acquired data, as well as novel and meaningful anatomical contrast that cannot be obtained with conventional reconstruction methods. TDI has been used to reveal anatomical features in human and animal brains...
December 16, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29247239/biogas-production-from-food-waste-via-co-digestion-and-digestion-effects-on-performance-and-microbial-ecology
#16
Mirzaman Zamanzadeh, Live Heldal Hagen, Kine Svensson, Roar Linjordet, Svein Jarle Horn
In this work, performance and microbial structure of a digestion (food waste-only) and a co-digestion process (mixture of cow manure and food waste) were studied at mesophilic (37 °C) and thermophilic (55 °C) temperatures. The highest methane yield (480 mL/g VS) was observed in the mesophilic digester (MDi) fed with food waste alone. The mesophilic co-digestion of food waste and manure (McoDi) yielded 26% more methane than the sum of individual digestions of manure and food waste. The main volatile fatty acid (VFA) in the mesophilic systems was acetate, averaging 93 and 172 mg/L for McoDi and MDi, respectively...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29239028/recovery-of-myocardial-mechanics-in-kawasaki-disease-demonstrated-by-speckle-tracking-and-tissue-doppler-methods
#17
Emine Azak, Ibrahim Ilker Cetin, Hazım A Gursu, Ayse Esin Kibar, Murat Surucu, Ali Orgun, Utku Pamuk
AIM: To investigate myocardial deformation and function during treatment for Kawasaki disease (KD) in children. METHODS: We performed speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI) in 15 children with KD and 15 healthy children during treatment for KD. STE was performed for longitudinal and circumferential strain (S) and strain rate (SR) at the left ventricle (LV) and for longitudinal S and SR at the right ventricle (RV). TDI was performed at the base of interventricular septum (IVS), LV, and RV...
December 13, 2017: Echocardiography
https://www.readbyqxmd.com/read/29230597/presence-of-post-systolic-shortening-is-an-independent-predictor-of-heart-failure-in-patients-following-st-segment-elevation-myocardial-infarction
#18
Philip Brainin, Sune Haahr-Pedersen, Morten Sengeløv, Flemming Javier Olsen, Thomas Fritz-Hansen, Jan Skov Jensen, Tor Biering-Sørensen
Following an ischemic event post systolic shortening (PSS) may occur. We investigated the association between PSS in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI) and occurrence of cardiovascular events at follow-up. A total of 373 patients admitted with STEMI and treated with pPCI were prospectively included in the study cohort. All patients were examined by echocardiography a median of 2 days after admission (interquartile range, 1-3 days)...
December 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29230278/laparoscopic-repair-of-a-right-diaphragmatic-hernia-in-a-post-partum-lady
#19
Krish Kulendran, Cian Keogh, Heng-Chin Chiam
Traumatic diaphragmatic injuries (TDI) are often challenging to diagnose. Research suggests that no single diagnostic study is sensitive or specific enough to identify such an injury, unless there is established herniation of intrabdominal contents. It is a rare cause of small bowel obstruction, which carries a substantial mortality rate. This report describes a case of a 41-year-old pregnant female who presented with irretractable vomiting and abdominal pain secondary to a delayed presentation of right-sided TDI...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29226651/quantitative-distinction-of-morphological-characteristics-of-white-blood-cells-in-peripheral-blood-through-texture-analysis-using-gray-level-co-occurrence-matrix
#20
Mai Yamamoto, Keigo Kono, Maiko Kuroki, Satoru Murakami, Ruka Hayata, Kana Nanato, Minrong Shao, Keiko Miwa, Yutaka Tsutsumi, Kazunori Okada, Sanae Kaga, Nobuo Masauzi
BACKGROUND: Texture features are valuable clues for skilled technicians to differentiate peripheral blood (PB) white blood cells (WBCs). Some studies have tried to distinguish WBCs automatically by using texture analysis. However, no study so far has applied a gray level co-occurrence matrix (GLCM) to images of PB WBCs. Here, we developed a new GLCM method, called the CM-Tx method, for automatically distinguishing PB WBCs. METHODS: We used a total of 199 images of six different types of PB WBCs, taken from PB smears of 12 healthy volunteers, as objective standard images for the analysis...
November 1, 2017: Clinical Laboratory
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