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https://www.readbyqxmd.com/read/27914867/new-hbm-values-for-emerging-substances-inventory-of-reference-and-hbm-values-in-force-and-working-principles-of-the-german-human-biomonitoring-commission
#1
REVIEW
Petra Apel, Jürgen Angerer, Michael Wilhelm, Marike Kolossa-Gehring
The German Human Biomonitoring Commission (HBM Commission) derives health-related guidance values (Human Biomonitoring assessment values, HBM values) according to the procedures described in the HBM Commission's position papers. Since the last adaption of the methodology in 2014, the HBM Commission has established a series of new HBM values, mainly on the basis of internationally agreed TDI/RfD values, or of toxicologically well- founded points of departure observed in animal studies. The derivation of these new HBM values for HBCDD, triclosan, 2-MBT, PFOA and PFOS as well as for the metabolites of glycol ethers, of Hexamoll(®) DINCH(®), DPHP, DEHTP, NMP, NEP, and 4-MBC is specified, and the HBM values are presented together with already established HBM values for other substances...
September 17, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27901203/case-control-study-examining-the-impact-of-oral-health-problems-on-the-quality-of-life-of-the-families-of-preschoolers
#2
Ramon Targino Firmino, Monalisa Cesarino Gomes, Raquel Gonçalves Vieira-Andrade, Carolina Castro Martins, Saul Martins Paiva, Ana Flávia Granville-Garcia
The aim of this study was to evaluate the impact of dental caries, traumatic dental injuries (TDI), toothaches, and malocclusion on the oral health-related quality of life (OHRQoL) of the families of Brazilian preschool children. A population-based, matched case-control study involving 415 pre-schoolers aged 3-5 years was conducted. The case (impact on OHRQoL) and control groups (no impact on OHRQoL) were matched for age, gender, and family income at an 1:4 ratio. Impact on the OHRQoL of a family was assessed using the Brazilian version of the Early Childhood Oral Health Impact Scale (B-ECOHIS)...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27894060/combined-use-of-tissue-doppler-imaging-and-natriuretic-peptides-as-prognostic-marker-in-asymptomatic-aortic-stenosis
#3
Miquel Gomez Perez, Mireia Ble, Mercedes Cladellas, Lluis Molina, Joan Vila, Alexandra Mas-Stachurska, Laura Higueras-Ortega, Julio Marti-Almor
INTRODUCTION: Tissue Doppler imaging (TDI) and N-terminal-pro-Brain Natriuretic Peptide (NT-proBNP) provides useful non-invasive information about left ventricle filling pressures and both have demonstrated to be a prognostic marker in some valve disease as aortic stenosis (AS). OBJECTIVES: To assess the clinical value of combined TDI and NT-proBNP information in asymptomatic AS patients. MATERIAL AND METHODS: Prospective study of 350 initially asymptomatic moderate to severe AS patients with: Mean aortic valve area 0...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27888645/olfaction-in-patients-with-allergic-rhinitis-an-indicator-of-successful-mp-azeflu-therapy
#4
Ludger Klimek, Sophia C Poletti, Annette Sperl, Magdalena Spielhaupter, Cornel Bardenhewer, Joaquim Mullol, Karl Hörmann, Thomas Hummel
BACKGROUND: The purpose of this study was to investigate the effect of MP-AzeFlu on olfaction and the interaction between severity of allergic rhinitis and olfactory improvement after therapy. METHODS: A prospective, multicenter, observational study was performed on 47 patients with persistent allergic rhinitis. Duration and severity of allergic rhinitis was diagnosed and classified using the modified Allergic Rhinitis and its Impact on Asthma (ARIA) criteria and the proof of allergen sensitization from positive skin-prick tests, specific immonoglobulin E (IgE) in serum, and nasal provocation response...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27881171/assessment-of-left-atrial-mechanical-functions-and-atrial-electromechanical-delay-in-juvenile-idiopathic-arthritis-by-tissue-doppler-echocardiography
#5
Azza Z El Eraky, Nesrin M Handoka, Mona Sayed Ghaly, Samah Ismail Nasef, Nahed A Eldahshan, Ahmed M Ibrahim, Sherein Shalaby
BACKGROUND: Juvenile idiopathic arthritis (JIA) is a systemic chronic inflammatory disease. Studies using tissue Doppler imaging (TDI) for the evaluation of cardiac functions of children with JIA are limited. Thus, this study was conducted to evaluate Left ventricular function, left atrial mechanical functions and atrial electromechanical delay in JIA. METHODS: This study was carried out as a across sectional study. A total of 34 patients with active JIA and 34 controls were included...
November 24, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27881009/late-cardiac-effect-of-anthracycline-therapy-in-physically-active-breast-cancer-survivors-a-prospective-study
#6
A C Nagy, P GulAcsi-BArdos, Z CserEp, L Hangody, T Forster
The late-onset cardiotoxic effect of anthracycline is known, however the early detection and prevention of subclinical myocardial damage has not been fully understood yet. Besides medical therapy regular physical activities may also play a role in the prevention and reduction of side effects of chemotherapy. The aim of our present study was to detect the effect of regular physical activities on the diastolic function and on the symptoms of late heart failure in case of anthracycline chemotherapy. The prospective study included 55 female patients (age 31-65 year, average 49...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27876281/post-transplant-surveillance-for-acute-rejection-and-allograft-vasculopathy-by-echocardiography-usefulness-of-myocardial-velocity-and-deformation-imaging
#7
Michael Dandel, Roland Hetzer
Diagnosing and monitoring acute rejection (AR) and cardiac allograft vasculopathy (CAV) is essential for graft and transplant patient survival and, consequently, a major objective for heart transplant patient surveillance. Because functionally relevant CAV can arise and progress without clinical symptoms and sub-clinical ARs can facilitate the development of CAV, standard surveillance of AR and CAV includes routine endomyocardial biopsy (EMB) and coronary angiography (CA) screenings at pre-defined time intervals...
October 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27867131/neuronavigation-based-on-track-density-image-extracted-from-deterministic-high-definition-fiber-tractography-a-case-report
#8
Peng-Hu Wei, Fei Cong, Ge Chen, Ming-Chu Li, Xin-Guang Yu, Yu-Hai Bao
BACKGROUND: Diffusion tensor imaging(DTI)-based navigation is unable to resolve crossing fibers or to determine with accuracy the fanning, origin, and termination of fibers. It is important to improve the accuracy of localizing white matter fibers for improved surgical approaches. We propose a solution to this problem using navigation based on track density imaging(TDI)extracted from high definition fiber tractography(HDFT). CASE DESCRIPTION: A 28-year-old asymptomatic female patient with a left-lateral ventricle meningioma was enrolled in the present study...
November 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27857519/vitamin-e-effect-in-a-rat-model-of-toluene-diisocyanate-induced-asthma
#9
Andrea Daniela Muti, Alina Elena Pârvu, Leon Adrian Muti, Remus Moldovan, Adriana Mureşan
BACKGROUND AND AIM: The aim of the study was to evaluate vitamin E effect upon oxidative stress associated with toluene -2, 4-diisocyanate (TDI)-induced asthma in rats. METHODS: The five study groups were: control, vehicle, TDI, vehicle+E, TDI+E. TDI animals were sensitized by nasal administration of TDI 10% (5μl/nostril) between days 1-7 and 15-21. Between days 22-28 groups TDI+E and vehicle+E rats received vitamin E (50 mg/kg, i. v.), and control, vehicle and TDI groups received saline solution...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27852078/clomiphene-citrate-versus-letrozole-for-ovarian-stimulation-in-therapeutic-donor-sperm-insemination
#10
Hady El Hachem, Roland Antaki, Camille Sylvestre, Isaac-Jacques Kadoch, Louise Lapensée, Pierre Emmanuel Bouet
AIM: To compare clomiphene citrate (CC) and letrozole for ovarian stimulation (OS) in therapeutic donor sperm insemination (TDI) cycles. METHODS: Retrospective cohort study between January 2011 and June 2014 at a University-affiliated private IVF clinic in Montreal, Canada. 257 normo-ovulatory women ≤40 years of age with no history of infertility undergoing 590 TDI cycles in the absence of a male partner (single women and same-sex couples) or azoospermia were included...
November 17, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27847179/demonstration-of-rebound-phenomenon-following-abrupt-withdrawal-of-the-jak1-inhibitor-oclacitinib
#11
Tomoki Fukuyama, Joy Rachel Ganchingco, Wolfgang Bäumer
The janus kinase-inhibitor oclacitinib is licensed for the control of pruritus associated with allergic skin diseases in dogs. Strikingly, it has been clinically reported that abrupt withdrawal of oclacitinib leads to a rebound pruritus in dogs. Therefore, the primary objective of this study was to mimic the rebound phenomenon of oclacitinib using a chronic pruritic mouse model of allergic contact dermatitis. Chronic allergic contact dermatitis was induced by repetitive toluene-2,4-diisocyanate (TDI) challenge in BALB/c mice...
November 12, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27826597/are-the-current-classifications-and-radiographic-measurements-for-trochlear-dysplasia-appropriate-in-the-skeletally-immature-patient
#12
Matthew Stepanovich, James D Bomar, Andrew T Pennock
BACKGROUND: The assessment and classification of trochlear dysplasia in pediatric patients has yet to be well documented or validated. PURPOSE: To examine several different measurements/classifications of trochlear dysplasia in skeletally immature patients to assess inter- and intraobserver reliability and to determine which best correlates with patellar instability. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 3. METHODS: Radiographs and magnetic resonance imaging (MRI) scans of 36 skeletally immature patients undergoing surgery for patellar instability were compared with 27 age-matched cohort patients who had similar imaging for an acute knee injury but no clinical evidence of patellar instability...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27800451/time-from-the-beginning-of-the-right-ventricle-isovolumetric-contraction-to-the-peak-of-the-s-wave-a-new-tdi-indicator-for-the-non-invasive-estimation-of-pulmonary-hypertension
#13
Mozhgan Parsaee, Fereshteh Ghaderi, Azin Alizadehasl, Hooman Bakhshandeh
BACKGROUND: Echocardiography is a key screening tool in the diagnostic algorithm of pulmonary hypertension (PH). In addition, tissue doppler imaging (TDI) is a promising method for the noninvasive estimation of pulmonary artery pressure (PAP). OBJECTIVES: The aim of this study was to validate the accuracy of measuring the time from the beginning of the right ventricular isovolumetric contraction time (RV IVRT) to the peak of the S wave in the TDI of the base of the RV free wall (time to peak or TTP), as an indicator for the non-invasive estimation of pulmonary hypertension...
August 2016: Research in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27769850/integrated-exposure-and-risk-characterization-of-bisphenol-a-in-europe
#14
Dimosthenis A Sarigiannis, Spyros P Karakitsios, Evangelos Handakas, Konstantina Simou, Ermioni Solomou, Alberto Gotti
The current study aims at a comprehensive risk characterization of bisphenol A (BPA) supported by an integrated exposure modelling framework that comprises far field and near field exposure modelling coupled to a dynamic lifetime PBTK model. Exposure analysis was done on European data of BPA food residues and human biomonitoring (HBM). The latter were further assimilated through an advanced exposure reconstruction modelling framework to estimate the corresponding external and internal systemic dose of BPA and its metabolites...
October 18, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27767228/predictors-of-left-ventricular-systolic-function-recovery-in-the-setting-of-sinus-tachycardia-in-patients-with-cancer
#15
Saamir A Hassan, Syed Wamique Yusuf, Jyoti Sharma, Jasmine Khan, Michele Guindani, Vicente Valero, Mariana Chavez-McGregor, Jose Banchs
OBJECTIVES: To identify unique echocardiographic features that could be used to reliably predict LVEF recovery upon resolution of sinus tachycardia in patients with cancer. BACKGROUND: Sinus tachycardia may be a manifestation of underlying cardiomyopathy or can lead to a reversible form of dilated cardiomyopathy known as tachycardia-mediated cardiomyopathy. While distinguishing the two can be challenging, predicting recovery regardless of cause can be of significant clinical importance in the cancer population...
October 21, 2016: Echocardiography
https://www.readbyqxmd.com/read/27754092/os-20-06-daily-alcohol-consumption-affects-left-ventricular-diastolic-function-in-hypertension-a-tissue-doppler-study
#16
Leonardo Sechi, GianLuca Colussi, Marileda Novello, Francesca Pezzutto, Cristiana Catena
OBJECTIVE: Studies on heavy alcoholic drinkers have reported an association between alcohol intake and left ventricular (LV) function. The effect of moderate alcohol intake on LV function in hypertensive patients, however, is unknown. The aim of the study was to investigate the relationship between alcohol consumption and LV function in hypertension. DESIGN AND METHOD: In 335 non-alcoholic hypertensive patients (age 52 ± 14) we measured plasma glucose, lipids, and liver tests, and 24-h creatinine clearance (CrCl)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#17
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27742514/transient-diabetes-insipidus-after-discontinuation-of-vasopressin-in-neurological-icu-patients-case-series-and-literature-review
#18
Michael A Bohl, James Forseth, Peter Nakaji
BACKGROUND: Arginine vasopressin (AVP) is a common second-line or third-line vasopressor used in critically ill neurosurgical patients. Neurosurgical indications include hyperdynamic therapy for vasospasm, maintenance of cerebral perfusion pressure in patients with intracranial hypertension, and prevention of hypotension in patients with sepsis. CASE DESCRIPTION: A series of six neurosurgical patients receiving AVP infusions developed severe but transient diabetes insipidus (tDI) after cessation of AVP...
October 11, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27740479/diverging-wave-volumetric-imaging-using-subaperture-beamforming
#19
Pedro Santos, Geir Ultveit Haugen, Lasse Lovstakken, Eigil Samset, Jan D'hooge
Several clinical settings could benefit from 3-D high frame rate (HFR) imaging and, in particular, HFR 3-D tissue Doppler imaging (TDI). To date, the proposed methodologies are based mostly on experimental ultrasound platforms, making their translation to clinical systems nontrivial as these have additional hardware constraints. In particular, clinically used 2-D matrix array transducers rely on subaperture (SAP) beamforming to limit cabling between the ultrasound probe and the back-end console. Therefore, this paper is aimed at assessing the feasibility of HFR 3-D TDI using diverging waves (DWs) on a clinical transducer with SAP beamforming limitations...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27738230/haemodialysis-acutely-deteriorates-left-and-right-diastolic-function-and-myocardial-performance-an-effect-related-to-high-ultrafiltration-volumes
#20
Pantelis A Sarafidis, Vasilios Kamperidis, Charalampos Loutradis, Konstantinos Tsilonis, Fani Mpoutsiouki, Athanasios Saratzis, Georgios Giannakoulas, Georgios Sianos, Haralambos Karvounis
BACKGROUND: The effect of acute preload reduction during haemodialysis on left ventricle (LV) and right ventricle (RV) function is not well understood. This study aimed to evaluate acute changes in novel echocardiographic and tissue Doppler-derived indices of LV and RV function during the first and a standard weekly dialysis session and to examine the possible effect of acute intradialytic volume changes in LV and RV diastolic function and pulmonary circulation loading. METHODS: Forty-one adult patients receiving standard thrice-weekly haemodialysis participated in this study...
October 13, 2016: Nephrology, Dialysis, Transplantation
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