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https://www.readbyqxmd.com/read/28942608/early-anthracycline-induced-cardiotoxicity-monitored-by-echocardiographic-doppler-parameters-combined-with-serum-hs-ctnt
#1
Chu-Jie Zhang, Xiao-Li Pei, Fei-Yan Song, Ye Guo, Qun-Ling Zhang, Xian-Hong Shu, David H Hsi, Lei-Lei Cheng
PURPOSE: As growing numbers of long-term cancer survivors faced with the cardiac side effects by anthracycline treatment, it is necessary to explore the optimal monitoring method for the early detection of cardiac toxicity. METHODS: We conducted a retrospective analysis of 82 consecutive patients with diffuse large B-cell lymphoma treated with chemotherapy. Echocardiographic Doppler imaging-derived Tei index and mitral annular peak systolic velocity (Sm) measured by tissue Doppler imaging TDI, serum high-sensitivity cardiac troponin T (hs-cTnT) levels, and left ventricular ejection fraction (LVEF) by multigated radionuclide angiography (MUGA) were obtained before, after 2-4, and after 6-8 chemotherapy cycles...
September 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/28942133/bush-mint-hyptis-suaveolens-and-spreading-hogweed-boerhavia-diffusa-medicinal-plant-extracts-differentially-affect-activities-of-cyp1a2-cyp2d6-and-cyp3a4-enzymes
#2
Nicholas Ekow Thomford, Kevin Dzobo, Faustina Adu, Shadreck Chirikure, Ambroise Wonkam, Collet Dandara
ETHNO-PHARMACOLOGICAL RELEVANCE: Hyptis suaveolens (L) Poit and Boerhavia diffusa Linn are medicinal herbal plants commonly found in the tropics and sub-tropics. They are used to treat various conditions among them boils, dyslipidaemia, eczema, malaria, jaundice and gonorrhoea. Thus, the herbal medicinal extracts are now found as part of some commercial herbal formulations. There has not been adequate characterisation of these medicinal herbs on their effects on drug metabolising enzymes...
September 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28941391/chlorinated-paraffins-leaking-from-hand-blenders-can-lead-to-significant-human-exposures
#3
Bo Yuan, Anna Strid, Per Ola Darnerud, Cynthia A de Wit, Jessica Nyström, Åke Bergman
BACKGROUND: Chlorinated paraffins (CPs, polychlorinated n-alkanes) are versatile, high-production-volume chemicals. A previous study indicated that hand blenders leak CPs into prepared food. OBJECTIVES: (1) to estimate exposure to CPs from hand blender use compared to background CP exposure from diet; (2) to assess the risk from human dietary exposure to CPs from hand blender use; (3) to investigate how hand blenders leak out CPs. METHODS: CPs were analyzed in food market baskets, in cooking oil/water samples (1g oil/100mL water) mixed using 16 different hand blenders, and in dismantled components of the hand blenders...
September 20, 2017: Environment International
https://www.readbyqxmd.com/read/28940082/applicability-and-efficacy-of-diatom-indices-in-water-quality-evaluation-of-the-chambal-river-in-central-india
#4
Prateek Srivastava, Sarika Grover, Jyoti Verma, Ambrina Sardar Khan
Diatom indices have gained considerable popularity in estimation of the trophic state and degree of pollution in lotic ecosystems. However, their applicability and efficacy have rarely been tested in Indian streams and rivers. In the present study, benthic diatom assemblages were sampled at 27 sites along the Chambal River in Central India. PCA revealed three groups of sites, namely, heavily polluted (HVPL), moderately polluted (MDPL), and least polluted (SANT). A total of 100 diatom taxa belonging to 40 genera were identified...
September 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28937256/evaluation-of-left-and-right-ventricular-systolic-and-diastolic-electromechanical-synchrony-in-older-people-a-population-based-observational-study
#5
R Laszlo, H Konz, K Kunz, D Dallmeier, J Klenk, M Denkinger, W Koenig, D Rothenbacher, J M Steinacker
It is unknown whether physiological ageing also goes along with electromechanical asynchrony of contraction. Aim of the study was to evaluate synchrony of contraction in older people with ("non-healthy") or without ("healthy") evidence for structural cardiac disease. In 547 persons (age 76.7+/-5.5 years, 306 male, 241 female) recruited from a population-based cohort of the ActiFE-Um study including a random sample of people >/= 65 years old living in the region of Ulm, Germany, various PW- and TDI-Doppler based markers for asynchrony were obtained by echocardiography...
September 22, 2017: Physiological Research
https://www.readbyqxmd.com/read/28926528/the-improving-rural-cancer-outcomes-trial-a-cluster-randomised-controlled-trial-of-a-complex-intervention-to-reduce-time-to-diagnosis-in-rural-cancer-patients-in-western-australia
#6
Jon D Emery, Victoria Gray, Fiona M Walter, Shelley Cheetham, Emma J Croager, Terry Slevin, Christobel Saunders, Timothy Threlfall, Kirsten Auret, Anna K Nowak, Elizabeth Geelhoed, Max Bulsara, C D'Arcy J Holman
BACKGROUND: Rural Australians have poorer survival for most common cancers, due partially to later diagnosis. Internationally, several initiatives to improve cancer outcomes have focused on earlier presentation to healthcare and timely diagnosis. We aimed to measure the effect of community-based symptom awareness and general practice-based educational interventions on the time to diagnosis in rural patients presenting with breast, prostate, colorectal or lung cancer in Western Australia...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28913326/improvement-in-white-matter-tract-reconstruction-with-constrained-spherical-deconvolution-and-track-density-mapping-in-low-angular-resolution-data-a-pediatric-study-and-literature-review
#7
Benedetta Toselli, Domenico Tortora, Mariasavina Severino, Gabriele Arnulfo, Andrea Canessa, Giovanni Morana, Andrea Rossi, Marco Massimo Fato
INTRODUCTION: Diffusion-weighted magnetic resonance imaging (DW-MRI) allows noninvasive investigation of brain structure in vivo. Diffusion tensor imaging (DTI) is a frequently used application of DW-MRI that assumes a single main diffusion direction per voxel, and is therefore not well suited for reconstructing crossing fiber tracts. Among the solutions developed to overcome this problem, constrained spherical deconvolution with probabilistic tractography (CSD-PT) has provided superior quality results in clinical settings on adult subjects; however, it requires particular acquisition parameters and long sequences, which may limit clinical usage in the pediatric age group...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28901214/total-dose-iron-dextran-infusion-versus-oral-iron-for-treating-iron-deficiency-anemia-in-pregnant-women-a-randomized-controlled-trial
#8
A M Darwish, E E Khalifa, E Rashad, E Farghally
STUDY OBJECTIVE: To test safety, efficacy and cost-effectiveness of total dose infusion (TDI) of low molecular weight (LMW) iron dextran for treatment of iron deficiency anemia (IDA) during pregnancy in comparison to oral ferrous fumarate. DESIGN: Prospective interventional randomized controlled trial (RCT). Design classification. Canadian Task Force II3. SETTING: Antenatal clinic and causality unit of a tertiary care referral facility and University Hospital...
September 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28893266/myocardial-performance-index-in-female-athletes
#9
Zahraa Alsafi, Andreas Malmgren, Petri Gudmundsson, Martin Stagmo, Magnus Dencker
BACKGROUND: Long-term intensive training leads to morphological and mechanical changes in the heart generally known as "athlete's heart". Previous studies have suggested that the diastolic and systolic function of the ventricles is unaltered in athletes compared to sedentary. The purpose of this study was to investigate myocardial performance index (MPI) by pulsed wave Doppler (PWD) and by tissue Doppler imaging (TDI) in female elite athletes compared to sedentary controls. METHODS: The study consisted of 32 athletes (mean age 20 ± 2 years) and 34 sedentary controls (mean age 23 ± 2 years)...
September 11, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28873277/what-are-the-important-outcomes-in-traumatic-dental-injuries-an-international-approach-to-the-development-of-a-core-outcome-set
#10
Kate P Kenny, Peter F Day, Mohammad Owaise Sharif, Peter Parashos, Eva Lauridsen, Carlos Alberto Feldens, Nestor Cohenca, Tony Skapetis, Liran Levin, David J Kenny, Serpil Djemal, Olle Malmgren, Yongjin Chen, Misuhiro Tsukisboshi, Lars Andersson
BACKGROUND/AIMS: There are numerous treatment options following Traumatic Dental Injury (TDI). Systematic reviews of different treatments are challenging owing to the diversity of outcomes reported between clinical studies. This issue could be addressed through the development and implementation of a agreed and standardised collection of outcomes known as a Core Outcome Set (COS). The aim of this study was to develop a COS for TDI in children and adults. The secondary aim was to establish what, how, when and by whom these outcomes should be measured...
September 5, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28870428/retro-and-orthonasal-olfactory-function-in-relation-to-olfactory-bulb-volume-in-patients-with-hypogonadotrophic-hypogonadism
#11
Murat Salihoglu, Onuralp Kurt, Seyid Ahmet Ay, Kamil Baskoy, Aytug Altundag, Muzaffer Saglam, Ferhat Deniz, Hakan Tekeli, Arif Yonem, Thomas Hummel
INTRODUCTION: Idiopathic hypogonadotrophic hypogonadism (IHH) with an olfactory deficit is defined as Kallmann syndrome (KS) and is distinct from normosmic IHH. OBJECTIVE: Because olfactory perception not only consists of orthonasally gained impressions but also involves retronasal olfactory function, in this study we decided to comprehensively evaluate both retronasal and orthonasal olfaction in patients with IHH. METHODS: This case-control study included 31 controls and 45 IHH patients...
August 24, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28866176/electrospinning-of-gelatin-with-tunable-fiber-morphology-from-round-to-flat-ribbon
#12
Fuat Topuz, Tamer Uyar
The electrospinning of gelatin with tunable fiber morphology from round to flat/ribbon was shown, and the detailed studies were conducted to correlate the fiber morphology with electrospinning process parameters and gelatin concentration in electrospinning solution. Particularly, variations in the applied voltage and the concentration of gelatin led to the transition of fiber shape from round to flat/ribbon. The formation of flat-shaped fibers was attributed to rapid evaporation of the solvent (formic acid) from the fiber matrix with increasing the applied voltage and gelatin concentration...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28864498/new-ultrasonographic-screening-method-for-oropharyngeal-dysphagia-tissue-doppler-imaging
#13
Noriaki Manabe, Ken Haruma, Rui Nakato, Hiroaki Kusunoki, Tomoari Kamada, Jiro Hata
BACKGROUND: Ultrasound Tissue Doppler imaging (US-TDI) has been used to diagnose regional wall motion (WM) abnormalities in coronary artery disease, but has not been applied to oropharyngeal diseases. This study aimed first to validate an US-TDI method to assess cervical esophageal (CE) WM, and secondly to use the method to evaluate CE WM in patients with oropharyngeal dysphagia (OD). METHODS: First, we enrolled 22 healthy men (mean age: 59.7 years) who all underwent both US-TDI and videofluoroscopy (VF) and then esophageal high-resolution manometry (HRM) in the same week...
September 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28863688/a-high-voltage-pulse-generator-based-on-silicon-controlled-rectifier-for-field-reversed-configuration-experiment
#14
Munan Lin, Ming Liu, Guanghui Zhu, Yanpeng Wang, Peiyun Shi, Xuan Sun
A high voltage pulse generator based on a silicon-controlled rectifier has been designed and implemented for a field reversed configuration experiment. A critical damping circuit is used in the generator to produce the desired pulse waveform. Depending on the load, the rise time of the output trigger signal can be less than 1 μs, and the peak amplitudes of trigger voltage and current are up to 8 kV and 85 A in a single output. The output voltage can be easily adjusted by changing the voltage on a capacitor of the generator...
August 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28857447/perception-of-parents-and-self-reports-of-children-regarding-the-impact-of-traumatic-dental-injury-on-quality-of-life
#15
Érick Tássio Barbosa Neves, Matheus França Perazzo, Monalisa Cesarino Gomes, Carolina Castro Martins, Saul Martins Paiva, Ana Flávia Granville-Garcia
BACKGROUND/AIM: Traumatic Dental Injuries occur frequently among young children. The aim of this study was to evaluate the impact of traumatic dental injuries on oral health-related quality of life (OHRQoL) in preschool children using the Scale of Oral Health Outcomes for 5-year-old children (SOHO-5). MATERIALS AND METHODS: The present study involved 769 five-year-old children enrolled at public and private preschools. Two examiners underwent a training process which involved the determination of inter-examiner and intra-examiner agreement (Kappa statistic) for all clinical conditions (K > 0...
August 31, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28846062/association-of-the-salivary-triggering-receptor-expressed-on-myeloid-cells-its-ligand-peptidoglycan-recognition-protein-1-axis-with-oral-inflammation-kidney-disease
#16
Karita M Nylund, Hellevi Ruokonen, Timo Sorsa, Anna Maria Heikkinen, Jukka H Meurman, Fernanda Ortiz, Taina Tervahartiala, Jussi Furuholm, Nagihan Bostanci
BACKGROUND: Triggering Receptor Expressed on Myeloid Cells (TREM-1) is a cell-surface receptor involved in amplification of inflammatory response to bacterial infections, along with its ligand peptidoglycan recognition protein 1 (PGLYRP1). TREM-1 is shed by matrix metalloproteinases (MMPs) to its soluble (s) form. The aim of the study was to investigate association of sTREM-1 and PGLYRP1 with oral inflammatory burden among chronic kidney disease (CKD) patients at predialysis and post-transplantation stages...
August 28, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28841033/exploring-the-impact-of-malocclusion-and-dentofacial-anomalies-on-the-occurrence-of-traumatic-dental-injuries-in-adolescents
#17
Paulo Floriani Kramer, Luciana M Pereira, Mariana Cezar Ilha, Tássia Silvana Borges, Maria Perpétua Mota Freitas, Carlos Alberto Feldens
OBJECTIVE: To investigate the association between malocclusion/dentofacial anomalies and traumatic dental injuries (TDI) in adolescents. MATERIALS AND METHODS: The sample of this cross-sectional study comprised 509 adolescents aged 11 to 14 years enrolled at public schools in the city of Osório, southern Brazil. Parents answered a structured questionnaire addressing demographic and socioeconomic characteristics. An examiner who had undergone a training and calibration exercise recorded malocclusion/dentofacial anomalies (Dental Aesthetic Index, DAI), TDI (Andreasen), and dental caries (World Health Organisation)...
August 25, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28840383/comprehensive-echocardiographic-assessment-of-biventricular-function-in-the-rabbit-animal-model-in-cardiovascular-research-feasibility-and-normal-values
#18
Sara Roldan Ramos, Guido Pieles, Wei Hui, Ryo Ishii, Cameron Slorach, Mark K Friedberg
Quantification of cardiac structure and function is central in cardiovascular research. Rabbits are valuable research models of cardiovascular human disease; however, there is little normal data available. The aim of this study was to investigate feasibility and provide normal values for comprehensive echocardiographic assessment of biventricular function in rabbits. New Zealand white rabbits underwent trans-thoracic echocardiography using a general electric (GE) Vivid 7/E9 system with a 10 MHz transducer, under light sedation, to evaluate biventricular function and dimensions...
August 24, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28834203/traumatic-dental-injuries-in-brazilian-children-and-oral-health-related-quality-of-life
#19
Fernando Silva-Oliveira, Daniela Goursand, Raquel Conceição Ferreira, Paula Cristina Pelli Paiva, Haroldo Neves Paiva, Efigênia Ferreira Ferreira, Patrícia Maria Zarzar
BACKGROUND/AIM: Population-based studies that investigate the impact of TDI on oral health-related quality of life (OHRQoL) among school children and its association to socioeconomic factors are scarce and offer conflicting results. The aim of this study was to evaluate the impact of TDI on OHRQoL among school children and its association to socioeconomic status. MATERIAL AND METHODS: A cross-sectional study was conducted with 588 12-year-old children enrolled in public and private schools in the urban areas in the city of Diamantina (southeastern Brazil)...
August 23, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28828571/comparison-of-heavy-metal-levels-of-farmed-and-escaped-farmed-rainbow-trout-and-health-risk-assessment-associated-with-their-consumption
#20
Memet Varol, Muhammet Raşit Sünbül
In this study, levels of ten metals (arsenic, cadmium, cobalt, chromium, copper, iron, manganese, nickel, lead, and zinc) in muscles of farmed and escaped farmed rainbow trout (Oncorhynchus mykiss) in the Keban Dam Reservoir (Turkey) were determined. Also, human health risks associated with their consumption were assessed. Of ten metals, only Co and Fe levels in escaped rainbow trout were significantly higher than those in farmed rainbow trout. The metal levels in farmed and escaped rainbow trout were below the maximum permissible limits...
August 21, 2017: Environmental Science and Pollution Research International
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