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https://www.readbyqxmd.com/read/29142810/the-role-of-ivabradine-in-diastolic-heart-failure-with-preserved-ejection-fraction-a-doppler-echocardiographic-study
#1
Federico Cacciapuoti, Valerio Massimo Magro, Michele Caturano, Diana Lama, Fulvio Cacciapuoti
Background: Ivabradine (IVA) is effective in patients with coronary artery disease (CAD) or systolic heart failure in sinus rhythm. Its action consists in reducing heart rate (HR) and improving the time of left ventricular (LV) diastolic filling. The aim of this study was to evaluate the effects of IVA added to conventional therapy on patients with diastolic heart failure (DHF) and preserved ejection fraction (HFpEF). Methods: We evaluated 25 patients with DHF in the New York Heart Association (NYHA) Class II-III and sinus rhythm...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29137850/the-importance-of-subclinical-left-ventricular-dysfunction-and-blood-pressure-pattern-in-asymptomatic-type-2-diabetic-patients-the-diagnostic-and-prognostic-significance-of-tissue-doppler-parameters-left-ventricular-global-longitudinal-strain-and-nighttime
#2
Angelina Stevanovic, Milica Dekleva
The primary aims of this study have been to explore the diagnostic and prognostic significance of Tissue Doppler parameters (TDI), global longitudinal strain (GLS), and blood pressure (BP) pattern in normotensive diabetic patients. METHODS: The study consisted of 121 diabetic patients and 41 healthy subjects. Conventional and TDI echocardiography were performed on all patients, including E/Em (ratio of diastolic velocities). GLS was derived from two-dimensional speckle-tracking. Ambulatory BP monitoring (ABPM) was obtained over 24h...
September 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29136360/investigating-socioeconomic-position-in-dental-caries-and-traumatic-dental-injury-among-children-in-quebec
#3
P Da Rosa, Marie-Claude Rousseau, A Edasseri, M Henderson, B Nicolau
OBJECTIVES: Socioeconomic position (SEP) is inversely associated with most oral health outcomes, but the patterns of association may vary depending on the specific outcome. We estimated associations between SEP and two oral health outcomes, dental caries and traumatic dental injuries (TDI), in Quebec children. METHODS: We used data from the baseline visit of the QUALITY (QUebec Adipose and Lifestyle Investigation in Youth) Cohort, an ongoing study in Montreal and Quebec, Canada...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29133005/correlation-between-contrast-time-density-time-on-digital-subtraction-angiography-and-flow-an-in-vitro-study
#4
Denise Brunozzi, Sophia F Shakur, Rahim Ismail, Andreas Linninger, Chih-Yang Hsu, Fady T Charbel, Ali Alaraj
BACKGROUND: and Purpose Digital subtraction angiography (DSA) provides an excellent anatomic characterization of cerebral vasculature, but hemodynamic assessment is often qualitative and subjective. Various clinical algorithms have been produced to semi-quantify flow from data obtained from DSA, but few have tested these against reliable flow values. MATERIALS AND METHODS: An arched flow model was created and injected with contrast. 17 injections were acquired in anterior-posterior and lateral DSA projections, 4 injections were acquired in oblique projection...
November 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29131855/phytyl-fatty-acid-esters-in-vegetables-pose-a-risk-for-patients-suffering-from-refsum-s-disease
#5
Stephanie Krauß, Lea Michaelis, Walter Vetter
Patients suffering from Refsum's disease show mutations in the enzyme necessary for the degradation of phytanic acid. Accumulation of this tetramethyl-branched fatty acid in inner organs leads to severe neurological and cardiac dysfunctions which can even result in death. Thus, patients with Refsum's disease have to follow a specific diet resigning foods with high levels of phytanic acid and trans-phytol like products from ruminant animals with a tolerable daily intake (TDI) of ≤ 10 mg/d. We recently reported the occurrence of phytyl fatty acid esters (PFAE, trans-phytol esterified with a fatty acid) in bell pepper with trans-phytol amounts of up to 5...
2017: PloS One
https://www.readbyqxmd.com/read/29128807/apigenin-a-novel-candidate-involving-herb-drug-interaction-hdi-interacts-with-organic-anion-transporter-1-oat1
#6
Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang
BACKGROUND: Apigenin is a flavonoid compound, widely distributed in natural plants. Various studies have suggested that apigenin has inhibitory effects towards several drug transporters, such as the organic anion transporting (OAT) polypeptides, 1B1 and 1B3 (OATP1B1 and OATP1B3). However, the mechanism by which apigenin interacts with OAT1 has not been well studied. METHODS: MDCK cells stably-expressing OAT1 were used to examine the inhibitory effects of apigenin on OAT1...
June 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29127870/concentrations-of-several-phthalates-contaminants-in-egyptian-bottled-water-effects-of-storage-conditions-and-estimate-of-human-exposure
#7
Ghada Zaki, Tamer Shoeib
The occurrence and concentrations of six common phthalates were investigated for the first time in bottled water locally produced in the Egyptian market. The compounds investigated were dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), n-butyl benzyl phthalate (BBP), diethyl hexyl phthalate (DEHP), and Di-n-octyl phthalate (D-n-OP). A set of 108 bottled water samples from six different commercial brands of water bottled in transparent polyethylene terephthalate (PET) plastic bottles with high density polyethylene (HDPE) plastic caps were investigated...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29121301/tissue-doppler-assessment-of-diastolic-function-and-relationship-with-mortality-in-critically-ill-septic-patients-a-systematic-review-and-meta-analysis
#8
F Sanfilippo, C Corredor, A Arcadipane, G Landesberg, A Vieillard-Baron, M Cecconi, N Fletcher
Background: Myocardial dysfunction may contribute to circulatory failure in sepsis. There is growing evidence of an association between left ventricular diastolic dysfunction (LVDD) and mortality in septic patients. Utilizing echocardiography, we know that tissue Doppler imaging (TDI) variables e' and E/e' are reliable predictors of LVDD and are useful measurements to estimate left ventricular (LV) filling pressures. Methods: We conducted a systematic review and meta-analysis to investigate the association of e' and E/e' with mortality of patients with severe sepsis or septic shock...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29118885/mitral-annular-dynamics-and-left-ventricular-diastole
#9
Angel Lopez-Candales, Dagmar F Hernandez-Suarez, Francisco Lopez Menendez
Background: Though diastolic interrogation of the mitral annulus (MA) using tissue Doppler imaging (TDI) has been quite useful in assessing left ventricular (LV) diastolic function, the relative contribution of the previous cycle MA systolic displacement or velocity components to subsequent LV diastole has not been previously investigated. We therefore sought to determine the association between MA systolic dynamics and LV diastolic function parameters. Methods: For this retrospective study, only complete echocardiograms having good endocardial border resolution of both left atrial (LA) and LV chambers with M-mode (MAPSE) and tissue Doppler of the lateral MA (MA TDI S') as well as complete Doppler data to perform assessment of LV diastole were included in our analysis...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29118563/cardiac-dysfunction-as-an-early-predictor-of-portal-hypertension-in-chronic-hepatitis-c
#10
Cecilia Marconi, Mattia Bellan, Paola Giarda, Rosalba Minisini, Serena Favretto, Michela Emma Burlone, Lisa Franzosi, Mario Pirisi
Background: Cirrhotic cardiomyopathy is characterized by a set of cardiovascular modifications observed in advanced chronic liver disease. The aim of this study was to investigate cardiovascular alterations in chronic liver disease with different stages of fibrosis and to correlate cardiac involvement with endoscopic complications of portal hypertension. Methods: Seventy patients with chronic hepatitis C-related chronic liver disease and 20 sex- and age-matched controls underwent clinical evaluation, hepatic transient elastography, and echocardiography...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29114936/examination-of-olfactory-training-effectiveness-in-relation-to-its-complexity-and-the-cause-of-olfactory-loss
#11
Anna Oleszkiewicz, Sandra Hanf, Katie L Whitcroft, Antje Haehner, Thomas Hummel
OBJECTIVE: Although the effectiveness of olfactory training (OT) had already been documented, the optimal regimen for such training remains unexplored. We examined whether the complexity of OT, namely alteration of odor quantity and quality, increases its effectiveness. DESIGN: One-hundred eight patients (Mage = 60.1 ± 1) with postinfectious (n = 57) or idiopathic (n = 51) olfactory dysfunction underwent OT preceded and followed by examination of olfactory function...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29103088/left-ventricular-functions-in-children-with-newly-diagnosed-graves-disease-a-single-center-study-from-upper-egypt
#12
Kotb Abbass Metwalley, Hekma Saad Farghaly, Abdelrahman Abdelhamid
This study aimed to evaluate the left ventricular (LV) functions in a cohort of children with Graves' disease (GD). This is a cross-sectional case-control study. It included 36 children with GD and 36 healthy children matched for age and gender. Thyroid hormones (TSH, FT4, and FT3) and anti-thyroid autoantibodies [anti-thyroid peroxidase (anti-TPO), thyrotropin receptor (TRAbs), and thyroglobulin antibodies] were measured. Conventional and tissue Doppler imaging (TDI) echocardiographies were used to assess left ventricular systolic and diastolic functions...
November 4, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29098525/prognostic-value-of-real-time-three-dimensional-echocardiography-compared-to-two-dimensional-echocardiography-in-patients-with-systolic-heart-failure
#13
Frederico J N Mancuso, Valdir A Moises, Dirceu R Almeida, Dalva Poyares, Luciana J Storti, Flavio S Brito, Sergio Tufik, Angelo A V de Paola, Antonio C C Carvalho, Orlando Campos
Heart failure (HF) is associated with morbidity and mortality. Real-time three-dimensional echocardiography (RT3DE) may offer additional prognostic data in patients with HF. The study aimed to evaluate the prognostic value of real-time three-dimensional echocardiography (RT3DE). This is a prospective study that included 89 patients with HF and left ventricular ejection fraction (LVEF) < 0.50 who were followed for 48 months. Left atrium and ventricular volumes and functions were evaluated by RT3DE. TDI and two-dimensional echocardiography parameters were also obtained...
November 2, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29092529/a-new-experimental-scheme-for-nuclear-%C3%AE-resonance-time-domain-interferometry
#14
F Caporaletti, A I Chumakov, R Rüffer, G Monaco
Time-domain interferometry (TDI) based on nuclear resonant scattering of synchrotron radiation by Mössbauer nuclei is a promising technique to study slow dynamics at the interatomic length scale. In order to improve the efficiency of this technique, a new TDI scheme is developed involving the use of a nuclear absorber with a two-line energy spectrum combined with a single-line spectrum. Different from other TDI setups, the issue of external vibrations is much reduced since the two absorbers are at rest and no velocity transducer is used...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29072062/morpho-functional-cardiovascular-adaptation-in-hypertensive-patients-two-dimensional-speckle-tracking-echocardiographic-study
#15
Ines P Monte, Chiara DI Benedetto, Filippo A Atanasio, Valentina Losi, Salvatore Licciardi, Corrado Tamburino
BACKGROUND: Twenty-four-hour Blood Pressure (BP) variability is an important predictor of organ damage and cardiovascular events. Although epidemiological data are widely based on evaluation of office (Clinic) BP, 24-hour Ambulatory BP monitoring (ABPM) accurately assess the severity of hypertension to predict cardiovascular events in hypertensive patients, because it more accurately reflects BP load on heart and blood vessels. Conventional transthoracic echocardiography (TTE), such as M-mode and two-dimensional (2D), and more advanced techniques, such as tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE), are used to identify pathological changes of the hypertensive heart disease...
October 25, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29070458/-receptor-for-advanced-glycation-end-products-upregulates-muc5ac-expression-and-promotes-mucus-overproduction-in-mice-with-toluene-diisocyanate-induced-asthma
#16
Jing Xiong, Wen-Qu Zhao, Guo-Hua Huang, Li-Hong Yao, Hang-Ming Dong, Chang-Hui Yu, Hai-Jin Zhao, Shao-Xi Cai
OBJECTIVE: To explore the role of the receptor for advanced glycation end products (RAGE) in regulating the expression of MUC5AC and mucus production in a mouse model of toluene diisocyanate (TDI)?induced asthma. METHODS: BALB/c mice were randomly divided into control group, vehicle (AOO) group, TDI?induced asthma group and RAGE inhibitor (FPS?ZM1) group. PAS staining, Western blotting, and immunohistochemistry were used to analyze the changes in mucus production and MUC5AC expression in the airway of the mice, and the expression of p?ERK was detected with Western blotting...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29065189/establishment-of-a-novel-hepatocyte-model-that-expresses-four-cytochrome-p450-genes-stably-via-mammalian-derived-artificial-chromosome-for-pharmacokinetics-and-toxicity-studies
#17
Daisuke Satoh, Satoru Iwado, Satoshi Abe, Kanako Kazuki, Shinobu Wakuri, Mitsuo Oshimura, Yasuhiro Kazuki
The utility of HepG2 cells to assess drug metabolism and toxicity induced by chemical compounds is hampered by their low cytochrome P450 (CYP) activities. To overcome this limitation, we established HepG2 cell lines expressing major CYP enzymes involved in drug metabolism (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and CYP oxidoreductase (POR) using the mammalian-derived artificial chromosome vector. Transchromosomic HepG2 (TC-HepG2) cells expressing four CYPs and POR were used to determine time- and concentration-dependent inhibition and toxicity of several compounds by luminescence detection of CYP-specific substrates and cell viability assays...
2017: PloS One
https://www.readbyqxmd.com/read/29062362/assessment-of-elementary-school-teachers-level-of-knowledge-and-attitude-regarding-traumatic-dental-injuries-in-the-united-arab-emirates
#18
Manal A Awad, Eman AlHammadi, Mariam Malalla, Zainab Maklai, Aisha Tariq, Badria Al-Ali, Alaa Al Jameel, Hisham El Batawi
INTRODUCTION: In this cross-sectional study, the level of knowledge and attitude of elementary school teachers regarding traumatic dental injuries (TDI) were assessed. MATERIALS AND METHODS: A questionnaire was distributed to 330 elementary school teachers in 30 randomly selected schools in the Emirates of Sharjah and Dubai. The questionnaire collected information on participants' demographic characteristics, first aid training, and attitude about emergency management of TDI...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/29059558/dioxin-concentrations-in-dietary-supplements-containing-animal-oil-on-the-japanese-market-between-2007-and-2014
#19
Tomoaki Tsutsumi, Satoshi Takatsuki, Reiko Teshima, Rieko Matsuda, Takahiro Watanabe, Hiroshi Akiyama
We determined the concentrations of dioxins (polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls) in 46 dietary supplement products, containing the oil of fish, marine mammals, or egg yolk, on the Japanese market between 2007 and 2014. Dioxins were detected in 43 of the 46 products tested at concentrations from 0.00015 to 67 pg TEQ/g. The highest concentration of dioxins was found in a shark liver oil product which varied insignificantly in five batches collected over a two-year period...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29057491/insight-into-curcumin-nanomicelle-induced-derangements-in-male-reproduction-potential-an-experimental-study
#20
S Moshari, V Nejati, G Najafi, M Razi
This study was conducted to investigate the possible effects of nanomicelle curcumin (NMC) on spermatogenesis, sperm parameters and in vitro fertilisation potential. For this purpose, 24 mature male Wistar rats were divided into control and test groups. The animals in test groups received 7.5, 15 and 30 mg kg b.w(-1) of NMC (NO = 6 rats in each group). Following 48 days, the DNA integrity of testicular tissues, tubular differentiation (TDI) and spermiogenesis (SPI) indices, sperm parameters and DNA integrity were analysed...
October 23, 2017: Andrologia
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