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Alejandra Ramírez-Martínez, Estela Camarillo-Hernández, Magda Carvajal-Moreno, Manuel Vargas-Ortíz, Nathalie Wesolek, Guadalupe Del Carmen Rodriguez Jimenes, Miguel Ángel Garcia Alvarado, Alain-Claude Roudot, Marco Antonio Salgado Cervantes, Victor J Robles-Olvera
The present study evaluated the exposure of Southeast Mexican population to Aflatoxin M1 (AFM1) and M2 (AFM2) through the consumption of Oaxaca cheese. The intake of Oaxaca cheese was assessed via a food 7-day dairy questionnaire (N = 1100, 2014 and 2015). Thirty Oaxaca cheeses were randomly sampled, and the origin of the samples was also investigated. AFM1 and AFM2 were quantified by HPLC-FD. The exposure was assessed through the combination of the Probabilistic Density Functions (probabilistic approach)...
March 21, 2018: International Journal of Environmental Health Research
Luk Van Baelen, Karin De Ridder, Jérôme Antoine, Lies Gremeaux
Background: Although gabapentin has been licensed in the European Union only for neuropathic pain and epilepsy for patients who have partial seizures, it has also been prescribed in treatment for substance use disorders. Many studies report the potential risk of abuse of gabapentin by people with substance use disorders. The objective of this paper is to determine if people who have been in treatment for substance use disorders bought gabapentin in a time span that could indicate consumption at a dose that exceeded the maximum approved dose of 3600 mg/day...
2018: Archives of Public Health, Archives Belges de Santé Publique
Meixian Xiang, Li Wu, Hanwen Su, Bing Han, Huanxiang Liu, Xincai Xiao, Xian Yin, Ya Fan, Lang Zhang, Yuying Huang, Lei Zhao, Guangzhong Yang
Allergic rhinitis (AR), one of the common diseases of the upper respiratory system, is associated with high risk of nasopharyngeal carcinoma. Biyuanling Granules (BLG), a formulated preparation of traditional Chinese medicine, has been used in China for treatment of AR for more than a decade; however, its exact action against allergic rhinitis and the mechanism involved remain unclear. In this study, we studied the effects of BLG on allergic rhinitis induced by toluene-2, 4- diisocyanate (TDI) in guinea pigs...
February 27, 2018: Oncotarget
Megumi Akiyama, Yoshihiko Matsui, Junki Kido, Taku Matsushita, Nobutaka Shirasaki
The probability distributions of total potential doses of disinfection byproducts and volatile organic compounds via ingestion, inhalation, and dermal exposure were estimated with Monte Carlo simulations, after conducting physiologically based pharmacokinetic model simulations to takes into account the differences in availability between the three exposures. If the criterion that the 95th percentile estimate equals the TDI (tolerable daily intake) is regarded as protecting the majority of a population, the drinking water criteria would be 140 (trichloromethane), 66 (bromodichloromethane), 157 (dibromochloromethane), 203 (tribromomethane), 140 (dichloroacetic acid), 78 (trichloroacetic acid), 6...
March 16, 2018: Regulatory Toxicology and Pharmacology: RTP
Christine Prouty, Shima Mohebbi, Qiong Zhang
Given the increasing vulnerability of communities to the negative impacts of untreated wastewater, resource recovery (RR) systems provide a paradigm shift away from a traditional approach of waste separation and treatment towards a productive recovery of water, energy and nutrients. The aim of this research is to understand the relationships between factors that influence the adoption and sustainability of wastewater-based RR systems to inform technology implementation strategies. The study presents a theory-informed, community-influenced system dynamics (SD) model to provide decision-makers with an adaptable tool that simulates system-level responses to the strategies that are developed for the coastal town of Placencia, Belize...
March 7, 2018: Water Research
René Günther, Wiebke Schrempf, Antje Hähner, Thomas Hummel, Martin Wolz, Alexander Storch, Andreas Hermann
Background: Nonmotor symptoms are very common in neurodegenerative diseases. In patients suffering from amyotrophic lateral sclerosis (ALS), olfactory dysfunction was first reported more than 20 years ago; however, its pathophysiological correlates and further implications remain elusive. Methods: In this so far largest case-control study, we analyzed olfactory performance with the "Sniffin' Sticks," a validated olfactory testing kit used in clinical routine...
2018: Frontiers in Neurology
Eun Song Song, Somy Yoon, Joo Hyun Cho, Eun Mi Yang, Hwa Jin Cho, Young Youn Choi, Jae Sook Ma, Gwang Hyeon Eom, Young Kuk Cho
BACKGROUND: Kawasaki disease (KD) is known as systemic vasculitis, and more than half of the patients with KD have myocarditis, which can induce ventricular dysfunction. In this study, we evaluate left ventricular (LV) dysfunction in patients with KD based on the myocardial performance index (MPI) using pulse Doppler (PD) and tissue Doppler imaging (TDI), from the acute to convalescent phases. METHODS: We retrospectively studied 89 children diagnosed with KD from January 2010 to August 2012...
March 12, 2018: World Journal of Pediatrics: WJP
Anber Naqvi, Abdul Qadir, Adeel Mahmood, Mujtaba Baqar, Iqra Aslam, Farhan Sajid, Mehvish Mumtaz, Jun Li, Gan Zhang
The present study biomonitored the placental polychlorinated biphenyl (PCB) concentrations in women from Punjab Province, Pakistan, that provides the pioneer data for occurrence and body burden of PCBs in placental tissues from South Asian women. The ∑34 PCB concentrations in placental tissues were ranged from 20.2 to 115.98 ng/g lipid weight (lip. wt.), with predominance of tetra-PCB (54.67%). The levels of ∑8 DL-PCBs and ∑6 -indicator PCBs were ranged from 2.03 to 27.64 ng/g (lip. wt.) and 1.71 to 30...
March 11, 2018: Environmental Science and Pollution Research International
Shuang Liu, Zhengyu Guan, Xianfeng Zheng, Pingping Meng, Yonghuai Wang, Yang Li, Yan Zhang, Jun Yang, Dalin Jia, Chunyan Ma
AIMS: To assess LA diastolic and systolic function and atrial dyssynchrony in patients with heart failure with preserved ejection fraction (HFpEF) and to examine whether LA dysfunction and dyssynchrony account for the patients' symptoms of HFpEF. METHODS: Fifty-five patients with HFpEF, 31 asymptomatic patients with left ventricular diastolic dysfunction (LVDD) and 33 healthy individuals were enrolled in the study. The LA active ejection fraction (LAAEF) was calculated...
April 15, 2018: International Journal of Cardiology
Nitesh Tewari, Vijay Prakash Mathur, Neerja Singh, Subash Singh, Ramesh Kumar Pandey
BACKGROUND/AIMS: Traumatic dental injuries of primary-dentition (TDI-p) have a global prevalence of approximately 11-47%. They have immediate and long term effects. Original research analysing the long-term sequelae of TDI-p on permanent-dentition (LSP) are few in number. The aim of this study was to explore the correlation between age of TDI-p, type of TDI-p and LSP. MATERIAL AND METHODS: Retrospective analysis of patient-data from 2008-2017, reporting with LSP due to TDI-p was performed...
March 1, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Vincenzo Russo, Anna Rago, Andrea Antonio Papa, Giulia Arena, Luisa Politano, Gerardo Nigro
BACKGROUND: Atrial electromechanical delay (AEMD) is an echocardiographic parameter correlated with the onset of supraventricular arrhythmias in several clinical conditions. Inter-atrial septal pacing in the region of Bachmann's bundle (BB) has been shown to be safe and feasible in myotonic dystrophy type 1 (DM1) patients, with a low rate of sensing and pacing defects. The aim of this study was to assess the impact of temporary BB pacing compared with right atrial appendage (RAA) pacing on AEMD in DM1 patients undergoing pacemaker (PM) implantation for cardiac rhythm abnormalities...
February 27, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Xiaohui Zhang, Wei Zeng, Yuanmin Li, Dapeng Hou, Xiuchang Li, Wenbo Xu
BACKGROUND: There are no previous studies dealing with paroxysmal atrial fibrillation (AF) and hypertension using electrocardiogram and tissue doppler imaging (TDI). The aim of this study was to investigate and identify the predictive indicators for paroxysmal AF in hypertensive patients using P wave dispersion (Pd) and TDI. METHODS: Patients with hypertension were enrolled. Patients with paroxysmal AF were classified as the PAF group, and patients without a history of paroxysmal AF were classified as the NAF group...
February 22, 2018: Heart Surgery Forum
Katherine L Whitcroft, Mandy Cuevas, Peter Andrews, Thomas Hummel
BACKGROUND: Our primary aim in this study was to determine which of the "Sniffin' Sticks" subtest components (threshold, discrimination, or identification) best reflect overall change in olfactory function during treatment for chronic rhinosinusitis (CRS). Our secondary aim was to determine whether duration of CRS affects olfactory outcomes after treatment. METHODS: A retrospective cohort study was performed. Sniffin' Sticks test scores from patients medically treated for CRS at our center from 1999 to 2016 were analyzed...
February 26, 2018: International Forum of Allergy & Rhinology
Cetin Gecmen, Ozkan Candan, Muzaffer Kahyaoglu, Arzu Kalayci, Ender Ozgun Cakmak, Ahmet Karaduman, Ibrahim Akin Izgi, Cevat Kirma
In this study, our objective was to evaluate right ventricular functions with speckle-tracking and conventional echocardiographic methods in patients with acute inferior myocardial infarction and to investigate the correlation between the echocardiographic parameters and the prediction of the proximal RCA lesions. 77 patients were included in this study. Patients with a RCA occluded proximal to the right ventricular branch were assigned to Group 1 and patients with an RCA occlusion distal to the right ventricle branch were assigned to Group 2...
February 26, 2018: International Journal of Cardiovascular Imaging
Mareeshty Damarasingh, Wagner Marcenes, Stephen A Stansfeld, Eduardo Bernabé
OBJECTIVE: To explore the association between illicit drug use and traumatic dental injuries (TDI) among adolescents. METHOD: We used data from 618 adolescents who participated in Phases I and III of Research with East Adolescents Community Health Survey (RELACHS), a longitudinal school-based study of adolescents in East London. Illicit drug use was collected when participants were 11-12 and 15-16 years old (Phases I and III, respectively). Clinical examinations for TDI were conducted in Phase III only...
February 23, 2018: Acta Odontologica Scandinavica
Edoardo Sciatti, Enrico Vizzardi, Assunta Castiello, Francesca Valentini, Ivano Bonadei, Sandro Gelsomino, Roberto Lorusso, Marco Metra
BACKGROUND: Hypertension is strongly related to arterial stiffness in a cause-effect fashion. Diabetes mellitus is also thought to determine vascular damage, mostly by means of advanced glycosylation end-products (AGEs). Aim of our study was to study the role of type 2 diabetes mellitus (T2DM) as regard ascending aortic elastic properties in hypertensive patients. METHODS: We prospectively enrolled outpatients with hypertension (n = 99) and type 2 diabetes mellitus plus hypertension (n = 42) without cardiovascular events...
February 19, 2018: Echocardiography
Stefano Petti, Ulf Glendor, Lars Andersson
Traumatic dental injuries (TDIs) account for a considerable proportion of bodily injuries. Nevertheless, global TDI frequency is unknown, probably because TDI diagnosis is not standardized. This study estimated world TDI frequency. A literature search (publication years 1996-2016) was aimed at covering as many countries, communities, ethnic groups as possible, thus achieving high generalizability. In particular, nonspecific keywords, no language restrictions and large databanks were used. Observational studies reporting proportions of individuals with at least one TDI (prevalence) and who developed TDI (incidence rate) were considered...
February 18, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Raffaelina Mercogliano, Serena Santonicola
Bisphenol A (BPA), widely used as additive in food packaging, is an environmental and food contaminant that shows a weak estrogenic activity in general population and toxicity in the infant population. A temporary tolerable daily intake (t-TDI) of 4 μg/kg bw/day and a migration limit of 0.6 mg/kg in food from plastic materials, intended to come in contact with food, were fixed. Dietary milk is important in the human diet. The review investigated the contamination levels in human milk and along the dairy supply chain...
February 12, 2018: Food and Chemical Toxicology
Mariana Freschi Bombini, Fernando Augusto Peres, Aline Tamires Lapa, Nailú Angélica Sinicato, Beatriz Ricato Quental, Ágatha de Souza Melo Pincelli, Tiago Nardi Amaral, Caroline Cristina Gomes, Ana Paula Del Rio, João Francisco Marques-Neto, Lilian T L Costallat, Paula Teixeira Fernandes, Fernando Cendes, Leticia Rittner, Simone Appenzeller
BACKGROUND/PURPOSE: To evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes. METHODS: Consecutive SLE and SSc patients were enrolled in this study. Clinical, laboratory disease activity and damage were assessed according to diseases specific guidelines...
February 11, 2018: Autoimmunity Reviews
Yazdan Ghandi, Mehrzad Sharifi, Danial Habibi, Fatemeh Dorreh, Mojtaba Hashemi
Background: The prevalence of obesity is increasing worldwide. Obese children without hypertension are becoming an important health challenge. Aims: Complications of obesity in adults are well established, but in obese children, cardiac dysfunction has not been reported clinically. Settings and Design: The present crosssectional study investigates subclinical systolic and diastolic dysfunction using echocardiographic modalities. Materials and Methods: Twentyfive youngsters with body mass index (BMI) >30 and 25 healthy children with BMI <25 were assigned into case and control group, respectively...
January 2018: Annals of Pediatric Cardiology
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