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Prognostic factors in cervical cancer

Omar Mahmoud, Lara Hathout, Sherif G Shaaban, Mohamed A Elshaikh, Sushil Beriwal, William Small
PURPOSE: The Gynecologic Oncology group (GOG) 0263 trial is currently exploring whether adding chemotherapy to adjuvant radiotherapy improves recurrence-free and/or overall survival in stage IB-IIA cervical cancer patients with pathologic intermediate-risk factors. Using the National Cancer Data Base, we evaluated the benefit of adjuvant chemoradiotherapy over adjuvant radiotherapy alone in the community practice setting. MATERIALS: The analysis included 869 stage IB-IIA cervical cancer patients who underwent radical hysterectomy retrieving intermediate-risk factors justifying adjuvant therapy...
October 18, 2016: Gynecologic Oncology
S F Lax, K F Tamussino, P F Lang
Malignancies of the uterus metastasize by direct invasion of neighboring structures, lymphatically or hematogenously. Endometrial and cervical cancers lymphatically spread to the pelvic and para-aortic lymph nodes. For endometrial cancer the depth of myometrial invasion, lymphosvascular space involvement (LVSI) and a microcystic, elongated and fragmented (MELF) glandular invasion pattern are predictors for lymph node metastases. Metastases to the pelvic lymph nodes occur in approximately 10 % of endometrial cancer patients and in 30 % of these cases the para-aortic lymph nodes are also involved...
October 18, 2016: Der Pathologe
Mijin Kim, Won Gu Kim, Suyeon Park, Hyemi Kwon, MinJi Jeon, Jong Jin Lee, Jin-Sook Ryu, Tae Yong Kim, YoungKee Shong, Won Bae Kim
BACKGROUND: For patients with lung metastases of differentiated thyroid carcinoma (DTC), there is no consensus on the maximal size of metastatic lesions to use when determining the intensity of follow-up and additional therapeutic options. We evaluated the clinical outcomes and survival of patients with metastatic DTC confined to the lung, using the maximal diameter of lung lesions in the initial computed tomography (CT). METHODS: This retrospective cohort study included 112 DTC patients with metastases confined to the lung...
October 17, 2016: Thyroid: Official Journal of the American Thyroid Association
Fei Sun, Lu Xiao, Xin-Xing Jang, Ying Xiong, Qi Li, Xiao-Jing Yue, Yun-Jian Wei, Yan-Xing Wei, Yan-Lin Ma, Yan-Hong Yu
Transient receptor potential vanilloid 6 (TRPV6) has been shown to promote caner proliferation in several solid tumors, leading to unfavorable clinical outcomes. Our study aimed to elucidate the clinical significance of TRPV6 in patients with early-stage cervical squamous cell carcinoma (CSCC). The mRNA expression of TRPV6 was measured in 12 paired early-stage CSCC specimens and six cervical carcinoma cell lines using quantitative real-time PCR (qRT-PCR). Western blotting and immunohistochemistry (IHC) were employed to examine the protein expression level of TRPV6 in four paired specimens, 175 paraffin-embedded early-stage CSCC specimens, and 50 normal cervical tissues (NCTs), respectively...
October 17, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yeon-Joo Kim, Joo-Young Kim, Youngkyong Kim, Young Kyung Lim, Jonghwi Jeong, Chiyoung Jeong, Meyoung Kim, Myong Cheol Lim, Sang-Soo Seo, Sang-Yoon Park
OBJECTIVE: The purpose of this work was to identify prognostic factors for survival after magnetic resonance image (MRI)-guided brachytherapy combined with external beam radiotherapy for cervical cancer. MATERIAL AND METHODS: External beam radiotherapy of 45-50.4 Gy was delivered by either three-dimensional conformal radiotherapy or helical tomotherapy. Patients also received high-dose-rate MRI-guided brachytherapy of 5 Gy in 6 fractions. RESULTS: We analyzed 128 patients with International Federation of Gynecology and Obstetrics stage IB-IVB cervical cancer who underwent MRI-guided brachytherapy...
October 12, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Linda P Cho, Matthias Manuel, Paul Catalano, Larissa Lee, Antonio L Damato, Robert A Cormack, Ivan Buzurovic, Mandar Bhagwat, Desmond O'Farrell, Phillip M Devlin, Akila N Viswanathan
OBJECTIVE: To determine prognostic factors for progression-free survival (PFS) and overall survival (OS) for stage I-II cervical-cancer patients treated using computed-tomography (CT)-planned high-dose-rate (HDR) intracavitary brachytherapy (BT). METHODS: A total of 150 patients were treated for Stage I-II cervical cancer using CT-planned BT between 4/2004 and 10/2014. Of these, 128 were eligible for inclusion. Kaplan-Meier local control (LC), pelvic control (PC), overall survival (OS), and PFS estimates were calculated...
October 6, 2016: Gynecologic Oncology
Alexandre Escande, Christine Haie-Meder, Pierre Maroun, Sébastien Gouy, Renaud Mazeron, Thomas Leroy, Enrica Bentivegna, Philippe Morice, Eric Deutsch, Cyrus Chargari
OBJECTIVE: To study the prognostic value of leucocyte disorders in a prospective cohort of cervical cancer patients receiving definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT). RESULTS: 113 patients were identified. All patients received a pelvic irradiation concomitant with chemotherapy, extended to the para-aortic area in 13 patients with IVB disease. Neutrophilia and leukocytosis were significant univariate prognostic factors for poorer local failure-free survival (p = 0...
October 4, 2016: Oncotarget
Toshiyuki Seki, Hiroshi Tanabe, Chie Nagata, Jiro Suzuki, Kayo Suzuki, Hirokuni Takano, Seiji Isonishi, Kazuhiko Ochiai, Satoshi Takakura, Aikou Okamoto
OBJECTIVE: Patients with adeno/adenosquamous carcinoma may have a poorer prognosis than patients with squamous cell carcinoma. Radiotherapy and concurrent chemoradiotherapy are used as adjuvant therapies for cervical cancer, regardless of the histological subtype. The aim of this study was to investigate the prognostic outcome of adjuvant therapy for patients with adeno/adenosquamous carcinoma with pathological risk factors. METHODS: The medical records of 135 patients with stage IB-IIB cervical cancer with squamous cell carcinoma or adeno/adenosquamous carcinoma who underwent primary surgery followed by adjuvant therapy were retrospectively reviewed...
September 27, 2016: Japanese Journal of Clinical Oncology
Kyu Chan Lee, Hun Jung Kim, KiHoon Sung, Young Eun Choi, Seok Ho Lee, Soyi Lim, Kwang Beom Lee, Jin Woo Shin, Chan Yong Park, Young Saing Kim, Sun Jin Sym, Young Sup Shim, Seung Joon Choi
OBJECTIVES: We investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer. METHODS: We conducted a review of 40 patients treated with RT. All patients received external beam RT and intracavitary brachytherapy. The primary tumor volume and squamous cell carcinoma antigen levels were measured pre-RT and mid-RT. Overall survival (OS) and progression free survival (PFS) were estimated, and possible prognostic factors for survival were analyzed...
September 23, 2016: International Journal of Gynecological Cancer
Xiaofeng Zhang, Fengshuang Li, Prof Linzhong Zhu
AIM: To investigate expression pattern, clinical significance and potential roles of fyn related kinase (FRK) in cervical cancer. METHODS: Expression of FRK protein and mRNA in 100 pairs of cervical cancer and matched non-cancerous tissue samples were detected by Western blot, immunohistochemistry and quantitative PCR, respectively. Statistical analyses were performed to evaluate associations of FRK protein expression with various clinicopathologic features and patients' prognosis...
September 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jiayuan Wu, Caixia Liang, Manyu Chen, Wenmei Su
Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor-stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field of predicting tumor prognosis. However, the prognostic value of TSR in solid tumors necessitates further elucidation. We conducted a meta-analysis on 14 studies with 4238 patients through a comprehensive electronic search on databases updated on May 2016 to explore the relationship between TSR and prognosis of solid tumors. The overall hazard ratio showed that rich stroma in tumor tissue was associated with poor overall survival (OS) (14 studies, 4238 patients) and disease-free survival (DFS) (9 studies, 2235 patients) of patients with solid tumors...
September 20, 2016: Oncotarget
Annukka Pasanen, Taru Tuomi, Jorma Isola, Synnöve Staff, Ralf Bützow, Mikko Loukovaara
OBJECTIVE: The aim was to study the association of L1 cell adhesion molecule (L1CAM) expression with the outcome of patients with endometrial cancer, especially with regard to conventional risk variables, and to compare the patterns of relapse in L1CAM-positive and -negative cancers. METHODS: This was a retrospective study of 805 women. The Kaplan-Meier method and univariate and multivariate Cox regression models were applied for survival analyses. Missing data were replaced using multiple imputation...
October 2016: International Journal of Gynecological Cancer
Juan Zhou, San-Gang Wu, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Qiong-Hua Chen, Zhen-Yu He
PURPOSE: To evaluate the clinical outcomes in patients with International Federation of Gynecology and Obstetrics (FIGO) stage I to IVA squamous cell carcinoma (SCC), adenocarcinoma (AC), and adenosquamous carcinoma (ASC) of the uterine cervix after definitive radiotherapy. METHODS: Patients with a primary diagnosis of FIGO stage I-IVA SCC, AC, and ASC of the uterine cervix who had undergone definitive beam radiation with implants or isotopes between 1988 and 2013 were identified using the Surveillance, Epidemiology, and End Results database...
September 19, 2016: Journal of Cancer Research and Clinical Oncology
Shane R Stecklein, Anuja Jhingran, Jennifer Burzawa, Preetha Ramalingam, Ann H Klopp, Patricia J Eifel, Michael Frumovitz
OBJECTIVE: To analyze patterns of recurrence and survival and identify prognostic factors in women with neuroendocrine cervical cancer (NECC). METHODS: We reviewed patients with International Federation of Gynecology and Obstetrics stage I-IVA NECC who were enrolled in the Neuroendocrine Cervical Tumor Registry and treated with curative intent. Event-free survival (EFS) and overall survival (OS) according to disease and treatment characteristics were analyzed using the Kaplan-Meier method...
September 16, 2016: Gynecologic Oncology
Wei Wang, Hong-Juan Chu, Yan-Chun Liang, Jia-Ming Huang, Chun-Liang Shang, Hao Tan, Duo Liu, Yun-He Zhao, Tian-Yu Liu, Shu-Zhong Yao
Fatty acid-binding protein 5 (FABP5) was found in our previous study to be a potential biomarker for lymph node metastasis of cervical cancer. However, the roles of FABP5 in cervical cancer remain unclear. In the present study, FABP5 expression was found to be significantly upregulated in cervical cancer tissues, and high FABP5 expression was significantly correlated with lymph node metastasis, lymphovascular space invasion, the International Federation of Gynecology and Obstetrics (FIGO) stage, and tumor size...
September 19, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Tomoka Usami, Akimasa Takahashi, Maki Matoda, Sanshiro Okamoto, Eiji Kondo, Hiroyuki Kanao, Kenji Umayahara, Nobuhiro Takeshima
OBJECTIVES: In most patients, stage IVB cervical cancer is incurable, and the outcomes are poor. There is significant individual variation in patients with stage IVB cervical cancer, in whom standard treatment has not been well defined. This study aims to review the outcomes and discuss treatment strategies in patients with stage IVB cervical cancer. METHODS: From January 1, 1992, to December 31, 2011, we retrospectively reviewed the data of patients with stage IVB cervical cancer who were given a diagnosis at the Department of Gynecology of the Cancer Institute Hospital...
September 2016: International Journal of Gynecological Cancer
Hao Yang, Cong Feng, Bo-Ning Cai, Jun Yang, Hai-Xia Liu, Lin Ma
The aim of this study was to evaluate the effectiveness and toxicities of three-dimensional conformal radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) in patients with cervical esophageal cancer. Specifically, we asked whether technological advances conferred an advantage with respect to the clinical curative effect. Seventy-eight patients with cervical esophageal cancer treated with definitive radiotherapy with or without concomitant chemotherapy at our institution between 2007 and 2014 were enrolled in the study: 26 received 3DCRT, 30 were treated with IMRT, and 22 underwent VMAT...
September 15, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
YongJie Huang, Yang Li, Fen F Wang, WeiGuo Lv, Xing Xie, Xiaodong Cheng
Cervical cancer is the most common cause of cancer-related deaths in women from developing countries. Identification of novel prognostic predictors or therapeutic targets may improve patient prognosis. In the current study, we demonstrated by real-time PCR that miR-224 expression was significantly upregulated (1.82-fold, P = 0.0025) in cervical cancer tissues (n = 126) compared with in normal cervical tissues (n = 64). Higher expression of miR-224 was significantly associated with poorer prognostic factors, including advanced FIGO stage, nodal metastasis, larger tumor size, vascular involvement and deep stromal invasion (all P < 0...
2016: PloS One
Sanaa Elmajjaoui, Nabil Ismaili, Hanane El Kacemi, Tayeb Kebdani, Hassan Sifat, Noureddine Benjaafar
BACKGROUND: On behalf of the medical staff of the National Institute of Oncology of Rabat, we conducted a retrospective study to report epidemiology and 5-year outcomes of cervical carcinoma in Moroccan women. METHODS: We reviewed all women diagnosed with invasive cervical carcinoma in our institute between January 2006 and December 2006. Outcomes and prognoses are analyzed in patients who received at least one treatment. RESULTS: The analysis included 646 women...
2016: BMC Women's Health
Uiju Cho, Hae-Mi Kim, Hong Sik Park, Oh-Joo Kwon, Ahwon Lee, Seong-Whan Jeong
OBJECTIVE: The protein GS28 (28-kDa Golgi SNARE protein) has been described as a SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors) protein family member that plays a critical role in mammalian ER-Golgi or intra-Golgi vesicle transport. Little is known about the possible roles of GS28 in pathological conditions. The purpose of this study was to evaluate GS28 expression in cervical cancer tissues and explore its correlation with clinicopathological features and prognosis...
2016: PloS One
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