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Prognostic factors in cervical cancer

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https://www.readbyqxmd.com/read/28535655/-clinical-analysis-of-surgery-for-recurrent-cervical-cancer-a-review-of-45-cases
#1
Y Han, L Y Wu, N Li, X G Li, R Zhang, Y C Sun
Objective: To study the efficacy of surgery for recurrent cervical cancer and the influencing factors on prognosis. Methods: To retrospectively analyze the clinical data of 45 patients with recurrent cervical cancer undergoing surgical treatment in our hospital from January 1980 to October 2015, and study their clinical features and prognosis. Results: The Recurrence Free Interval (RFI) of these 45 patients was 3~120 months, and their median RFI was 15 months. Of the 45 cases, 21 recurred inside the radiotherapy field, including 18 with central recurrence and 3 with non-central recurrence; and 24 recurred outside the radiotherapy field, including 16 with pelvic recurrence who did not receive radiotherapy and 8 with distant recurrence...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28534183/prognostic-importance-of-lymph-node-to-primary-tumor-standardized-uptake-value-ratio-in-invasive-squamous-cell-carcinoma-of-uterine-cervix
#2
Hyun Hoon Chung, Gi Jeong Cheon, Jae-Weon Kim, Noh-Hyun Park, Yong Sang Song
PURPOSE: Using integrated PET/CT, we evaluated the prognostic value of [(18)F]FDG uptake ratio between pelvic lymph node (LN) and primary tumor in invasive squamous cell carcinoma (SCCA) of the uterine cervix. METHODS: We retrospectively reviewed patients with International Federation of Gynecology and Obstetrics (FIGO) stages IB to IIA cervical SCCA who underwent preoperative [(18)F]FDG PET/CT scans. PET/CT parameters such as maximum standardized uptake value (SUV) of the primary cervical cancer (SUVcervix) and LN (SUVLN), and the LN-to-cervical cancer SUV ratio (SUVLN/SUVcervix) were assessed...
May 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28521296/the-prognostic-value-of-long-non-coding-rnas-in-cervical-cancer-a-meta-analysis
#3
Xiangrong Cui, Xuan Jing, Xueqing Wu
Cervical cancer is one of the most common malignancies in women worldwide. Numerous literatures demonstrate that aberrantly expressed lncRNAs are involved in tumorigenesis and development, and may have the potential to be prognostic markers. However, their prognostic functions in cervical remain controversial. Therefore, we performed this meta-analysis to evaluate the prognostic significance of lncRNAs in cervical cancer. We searched databases to identify relevant articles. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498261/clear-cell-carcinoma-of-the-uterine-cervix-a-clinical-and-pathological-analysis-of-47-patients-without-intrauterine-diethylstilbestrol-exposure
#4
Li Yang, Aiwen Zheng, Xiang Zhang, Xianhua Fang, Wenyong Sun, Yaqing Chen
OBJECTIVES: The aim of this study was to summarize the clinical and pathological characteristics and to conduct prognosis analysis of patients who were diagnosed with clear cell carcinoma of the uterine cervix (CCCUC) and without a history of exposure to diethylstilbestrol. METHODS: We performed a retrospective review of all the patients with CCCUC who were diagnosed and treated at Zhejiang Cancer Hospital between 1998 and 2014. Charts were reviewed for clinical and pathological characteristics, and prognosis analysis was conducted...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498238/nomogram-predicting-overall-survival-in-operable-cervical-cancer-patients
#5
Ru-Ru Zheng, Xiao-Wan Huang, Wen-Yue Liu, Rong-Rong Lin, Fei-Yun Zheng, Feng Lin
OBJECTIVE: Nomograms are widely used as predictive tools to predict oncological outcomes intuitively and precisely. The aim of our study was to develop a nomogram for predicting overall survival (OS) of patients with early stage cervical cancer. METHODS: In this retrospective study, the clinical, pathological, and hematological data and prognosis of 795 cervical cancer patients were investigated. We identified and incorporated independent significant prognostic factors for OS to develop a nomogram...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28492539/non-junctional-cx32-mediates-anti-apoptotic-and-pro-tumor-effects-via-epidermal-growth-factor-receptor-in-human-cervical-cancer-cells
#6
Yifan Zhao, Yongchang Lai, Hui Ge, Yunquan Guo, Xue Feng, Jia Song, Qin Wang, Lixia Fan, Yuexia Peng, Minghui Cao, Andrew L Harris, Xiyan Wang, Liang Tao
The role of connexin proteins (Cx), which form gap junctions (GJ), in progression and chemotherapeutic sensitivity of cervical cancer (CaCx), is unclear. Using cervix specimens (313 CaCx, 78 controls) and CaCx cell lines, we explored relationships among Cx expression, prognostic variables and mechanisms that may link them. In CaCx specimens, Cx32 was upregulated and cytoplasmically localized, and three other Cx downregulated, relative to controls. Cx32 expression correlated with advanced FIGO staging, differentiation and increased tumor size...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28466456/new-procedures-for-the-identification-of-sentinel-lymph-node-shaping-the-horizon-of-future-management-in-early-stage-uterine-cervical-cancer
#7
Diego Rossetti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Lymph node metastasis is one of the most important prognostic factors for uterine cervical cancer, although lymph node status is not part of the International Federation of Gynaecology and Obstetrics (FIGO) staging. Considering the increasing attention about the topic, we performed a comprehensive review of the literature, to assess the accuracy of real-time fluorescence sentinel lymph node (SLN) for the detection of nodal metastases in patients with early stage cervical cancer (ESCC). In this work, we discuss the different techniques for SLN mapping and the accuracy of each one of them and, basing on these data, summarize the most important recommendations...
May 2, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28463843/prognostic-parameters-for-patients-with-cervical-cancer-figo-stages-ia2-iib-a-long-term-follow-up
#8
Bogdan Obrzut, Andrzej Semczuk, Maciej Naróg, Marzanna Obrzut, Piotr Król
OBJECTIVE: We assessed the prognostic factors related to 10-year overall survival and disease-free survival in cervical cancer patients that underwent primary surgical protocols in 1 institution. MATERIALS AND METHODS: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that underwent a Piver type III radical hysterectomy and pelvic lymphadenectomy between 1998 and 2001 were included. Univariate and multivariate analyses of 10-year overall survival and 10-year disease-free survival were performed...
May 3, 2017: Oncology
https://www.readbyqxmd.com/read/28430988/prognostic-significance-of-surgical-extranodal-extension-in-head-and-neck-squamous-cell-carcinoma-patients
#9
Fumihiko Matsumoto, Taisuke Mori, Satoko Matsumura, Yoshifumi Matsumoto, Masahiko Fukasawa, Masanori Teshima, Kenya Kobayashi, Seiichi Yoshimoto
Background: Lymph node metastasis with extranodal extension represents one of the most important adverse prognostic factors for survival in patients with head and neck squamous cell carcinoma. We propose that extranodal extension occurs to differing extents. The aim of this study was to determine the prognostic significance of extranodal extension in patients with head and neck squamous cell carcinoma. Methods: Two hundred and ninety-eight patients with head and neck squamous cell carcinoma who underwent surgical resection and neck dissection were included...
April 18, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28423530/patterns-of-failure-and-clinical-outcomes-of-definitive-radiotherapy-for-cervical-esophageal-cancer
#10
Lina Zhao, Yongchun Zhou, Yunfeng Mu, Guangjin Chai, Feng Xiao, Lina Tan, Steven H Lin, Mei Shi
PURPOSE: Because of the scarcity of cervical esophageal cancer (CEC), data for this disease entity is limited. We aim to evaluate the outcomes, prognostic factors and failure patterns of CEC treated by contemporary radiotherapy (RT). METHODS: We retrospectively analyzed 86 CEC patients consecutively treated between 2007 and 2015 by definitive RT with or without concurrent chemotherapy. RT was mainly delivered with Intensity Modulated Irradiation Therapy (IMRT) or Volumetric-Modulated Arc Therapy (VMAT)...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405687/gins2-is-a-novel-prognostic-biomarker-and-promotes-tumor-progression-in-early-stage-cervical-cancer
#11
Fei Ouyang, Junling Liu, Meng Xia, Chuyong Lin, Xianqiu Wu, Liping Ye, Libing Song, Jun Li, Jing Wang, Peng Guo, Mian He
GINS complex subunit 2 (GINS2), a member of the GINS complex, is involved in DNA replication. GINS2 is upregulated in a variety of aggressive tumors. However, its role in cervical cancer carcinogenesis remains to be elucidated. We investigated the clinical significance of GINS2 in patients with early-stage cervical cancer and its biological functions in cervical cancer progression. GINS2 expression was analyzed in cervical cancer cell lines and in 8 matched cervical cancer samples at the mRNA and protein levels using real-time PCR and western blotting, respectively...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28401338/serum-he4-is-correlated-to-prognostic-factors-and-survival-in-patients-with-endometrial-cancer
#12
A Stiekema, Car Lok, C M Korse, W J van Driel, V van der Noort, G G Kenter, K K Van de Vijver
The extent of surgery and the decision for adjuvant treatment in patients with endometrial cancer (EC) depend on the presence of risk factors for lymph node metastases and disease recurrence. Postoperative markers such as myometrial infiltration and specific mutations can select patients for adjuvant treatment but will not influence surgical planning. A biomarker stratifying patients into low-risk and high-risk groups before surgery could identify patients who benefit from more extensive surgery. Therefore, we evaluated the correlation of serum biomarker HE4 with clinical and recently identified prognostic pathological variables and survival...
April 11, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28400350/extraperitoneal-lymph-node-dissection-in-locally-advanced-cervical-cancer-the-prognostic-factors-associated-with-survival
#13
Mehmet Faruk Köse, Mine Kiseli, Günsu Kimyon, Reyhan Öcalan, Müfit Celal Yenen, Gökhan Tolunay, Ahmet Taner Turan, Isin Üreyen, Nurettin Boran
OBJECTIVE: Surgical staging is recently recommended for decision of the treatment in locally advanced cervical cancer. We aimed to investigate the clinical outcomes as well as the factors associated with overall survival (OS) in locally advanced cervical cancer patients who had undergone extraperitoneal lymph node dissection and managed according to the lymph node status. MATERIAL AND METHODS: Medical records of 233 women with stage IIb-IVa cervical cancer who were clinically staged and undergone extraperitoneal lymph node dissection were retrospectively reviewed...
February 7, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28386210/re-evaluation-of-the-role-of-thoracoscopic-esophagectomy-as-a-japanese-style-radical-surgery
#14
Harushi Udagawa, Masaki Ueno, Shusuke Haruta, Tsuyoshi Tanaka, Aya Mizuno, Yu Ohkura
PURPOSE: To investigate the value of thoracoscopic surgery in radical esophagectomy with three-field lymphadenectomy. MATERIALS AND METHOD: The subjects were 329 consecutive patients who, without preoperative chemoradiotherapy, underwent R0 radical esophagectomy with three-field lymphadenectomy for thoracic squamous cell esophageal cancers during 1998-2013. Open thoracotomy was applied in 212 (O), and thoracoscopic surgery in 117 (V). Survivals according to TNM Stages and Efficacy index (EI) were analyzed...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28385388/microrna-138-is-a-potential-biomarker-and-tumor-suppressor-in-human-cervical-carcinoma-by-reversely-correlated-with-tcf3-gene
#15
Huiqin Li, Yang Sheng, Ying Zhang, Nan Gao, Xiangyun Deng, Xiugui Sheng
BACKGROUND: The aim of our work is to identify the functional mechanism of microRNA-138 (miR-138) in human cervical cancer. METHODS: MiR-138 expression was investigated by qRT-PCR in cervical cancer cell lines and human tumors. Correlations of patients' clinicopathological factors and overall survival with miR-138 expression were analyzed. In SiHa and HeLa cells, miR-138 was either upregulated or downregulated to evaluate its regulations on cervical cancer in vitro proliferation, invasion and in vivo xenograft growth...
April 3, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28385383/prognostic-significance-of-gene-amplification-of-actn4-in-stage-i-and-ii-oral-tongue-cancer
#16
T Kakuya, T Mori, S Yoshimoto, Y Watabe, N Miura, H Shoji, K Onidani, T Shibahara, K Honda
Despite complete resection of the early stage of oral tongue cancer by partial glossectomy, late cervical lymph node metastasis is frequently observed. Gene amplification of ACTN4 (protein name: actinin-4) is closely associated with the metastatic potential of various cancers. This retrospective study was performed to demonstrate the potential usefulness of ACTN4 gene amplification as a prognostic biomarker in patients with stage I/II oral tongue cancer. Fifty-four patients with stage I/II oral tongue cancer were enrolled retrospectively, in accordance with the reporting recommendations for tumour marker prognostic studies (REMARK) guidelines...
April 3, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28362704/downregulation-of-adamts18-may-serve-as-a-poor-prognostic-biomarker-for-cervical-cancer-patients
#17
Lin Zhang, Yibin Liu, Pengtao Zheng
ADAMTS18 is a member of ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family proteins which have been found to play important roles in cancer progression and metastasis in different cancer types. The present study aims at evaluating the prognostic significance of ADAMTS18 in cervical cancer. The expression levels of ADAMTS18 was evaluated by real-time PCR in normal (N=28) and cervical cancer tissues from patients at different stages as well as in tumor tissues from 35 cervical cancer patients with primary cancer and 29 patients with metastasis...
March 30, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28357468/salvage-radiotherapy-with-or-without-concurrent-chemotherapy-for-pelvic-recurrence-after-hysterectomy-alone-for-early-stage-uterine-cervical-cancer
#18
Sang-Won Kim, Mison Chun, Hee-Sug Ryu, Suk-Joon Chang, Tae Wook Kong, Eun Ju Lee, Yong Hee Lee, Young-Taek Oh
PURPOSE: Treatment outcomes of patients with pelvic recurrence after hysterectomy alone for uterine cervical cancer who received salvage radiotherapy (RT) with or without concurrent chemotherapy were investigated. METHODS: Salvage RT for recurrent cervical cancer confined to the pelvic cavity after hysterectomy alone was received by 33 patients. The median interval between initial hysterectomy and recurrence was 26 months. Whole-pelvic irradiation was delivered to median dose of 45 Gy, followed by a boost with a median dose of 16 Gy to the gross tumor volume...
March 29, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28355940/immunohistochemical-analysis-of-egfr-and-hyaluronan-in-tongue-cancer-and-the-development-of-regional-recurrence-in-patients-initially-diagnosed-n0
#19
Eva Lindell Jonsson, Karin Nylander, Lars Hallén, Göran Laurell
OBJECTIVE: To investigate whether the extent of expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the mobile tongue can predict the risk of cervical metastasis and survival. STUDY DESIGN: Retrospective histopathologic study. METHODS: Surgical specimens from 64 patients who had undergone surgery for squamous cell carcinoma of the mobile tongue were assessed using immunohistochemistry to investigate the expression of HA and EGFR in the primary tumours, and the data were then correlated to cervical metastasis and survival...
March 30, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28337289/overexpression-of-trim24-is-correlated-with-the-progression-of-human-cervical-cancer
#20
Li Lin, Weihua Zhao, Bo Sun, Xinyu Wang, Qiao Liu
TRIM24, originally known as intermediary factor 1-alpha, is involved in the development of several cancers. This study aimed to evaluate the expression level and prognostic value of TRIM24 in cervical cancer. In the present study, we showed that the expression of TRIM24 was markedly upregulated in cervical cancer cell lines and cancerous specimens at both transcriptional and translational levels. TRIM24 expression was analyzed in 147 archived cervical cancer specimens using immunohistochemistry, and the correlation between TRIM24 expression and clinicopathological parameters was evaluated...
2017: American Journal of Translational Research
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