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Prognostic factors in cervical cancer

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https://www.readbyqxmd.com/read/28916879/a-score-combining-baseline-neutrophilia-and-primary-tumor-suvpeak-measured-from-fdg-pet-is-associated-with-outcome-in-locally-advanced-cervical-cancer
#1
Antoine Schernberg, Sylvain Reuze, Fanny Orlhac, Irène Buvat, Laurent Dercle, Roger Sun, Elaine Limkin, Alexandre Escande, Christine Haie-Meder, Eric Deutsch, Cyrus Chargari, Charlotte Robert
PURPOSE: We investigated whether a score combining baseline neutrophilia and a PET biomarker could predict outcome in patients with locally advanced cervical cancer (LACC). METHODS: Patients homogeneously treated with definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT) between 2006 and 2013 were analyzed retrospectively. We divided patients into two groups depending on the PET device used: a training set (TS) and a validation set (VS). Primary tumors were semi-automatically delineated on PET images, and 11 radiomics features were calculated (LIFEx software)...
September 15, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28915656/patterns-and-clinical-significance-of-cervical-lymph-node-metastasis-in-papillary-thyroid-cancer-patients-with-delphian-lymph-node-metastasis
#2
Guibin Zheng, Hua Zhang, Shaolong Hao, Chengxin Liu, Jie Xu, Jinyao Ning, Guochang Wu, Lixin Jiang, Guojun Li, Haitao Zheng, Xicheng Song
Although the roles of Delphian lymph node (DLN) metastasis in papillary thyroid cancer (PTC) have been previously reported, there are still limited data on correlations of clinicopathologic factors with DLN metastasis and unique patterns of cervical node subsite metastasis in PTC patients with DLN metastasis. We retrospectively reviewed medical records of 320 patients with a diagnosis of PTC who underwent primary surgery. Clinicopathologic features and DLN metastasis patterns were analyzed for predicting extensive cervical lymph node metastasis...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913152/early-vulvar-and-umbilical-incisional-scar-recurrence-of-cervical-squamous-cell-carcinoma-earlier-than-usually-expected
#3
Hüseyin Çağlayan Özcan, Aynur Mustafa, Zehra Bozdağ, Seyhun Sucu, Mete Gürol Uğur, Özcan Balat
Cutaneous metastasis is considered as a hazardous condition depending on the mean survival around 9 months, which usually originates from cancers of the breast, lung, ovary, colon, and rarely from the cervix. The crucial prognostic factor of cutaneous metastasis depends on the period between the primary malignancy and cutaneous metastasis. We report two cases of the unusual presentation of squamous cell cancer of the cervix that developed vulvar and umbilical metastasis in the 5(th) month of primary treatment...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28913135/prognostic-risk-factors-for-lymph-node-involvement-in-patients-with-endometrial-cancer
#4
Tayfun Toptaş, Tayup Şimşek, Şeyda Karaveli
OBJECTIVE: We aimed to analyze variables affecting lymph node (LN) involvement and to assess the need for systematic lymphadenectomy in patients with endometrial cancer (EC). MATERIALS AND METHODS: A single centre retrospective analysis was conducted in a total of 128 consecutive patients with EC who underwent systematic pelvic or combined pelvic and paraaortic lymphadenectomy between 2009 and 2012. Mann-Whitney U, chi-square, and Fisher's exact test were used for univariate analyses when appropriate...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28903428/comparison-of-clinical-utilities-of-the-platelet-count-and-platelet-lymphocyte-ratio-for-predicting-survival-in-patients-with-cervical-cancer-a-single-institutional-study-and-literature-review
#5
Katsumi Kozasa, Seiji Mabuchi, Naoko Komura, Eriko Yokoi, Kuroda Hiromasa, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Eiji Kobayashi, Tadashi Kimura
OBJECTIVE: To compare the clinical utilities of the platelet count and platelet-lymphocyte ratio (PLR) for predicting survival in patients with cervical cancer. RESULTS: Multivariate analyses demonstrated that thrombocytosis and elevated PLR were found to be independent prognostic factors for progression-free survival (PFS, P = 0.0077, P = 0.044) and overall survival (OS, P = 0.025, P = 0.019) in separate Multivariate analyses. In the ROC analysis, the platelet count showed a significantly greater area under the ROC curve (AUC) value than that of PLR for predicting patient recurrence (0...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902345/cx32-suppresses-extrinsic-apoptosis-in-human-cervical-cancer-cells-via-the-nf%C3%A2-%C3%AE%C2%BAb-signalling-pathway
#6
Yongchang Lai, Lixia Fan, Yifan Zhao, Hui Ge, Xue Feng, Qin Wang, Xiaomin Zhang, Yuexia Peng, Xiyan Wang, Liang Tao
Tumour necrosis factor α (TNFα) and TNF‑related apoptosis inducing ligand (TRAIL) usually trigger either survival or apoptosis signals in various cell types, and nuclear factor κB (NF‑κB) is a key factor that regulates their biological effects. Connexin 32 (Cx32) is a gap junction (GJ) protein that plays vital roles in tumourigenesis and tumour progression. Our previous study explored abnormal Cx32 expression in para‑nuclear areas, exacerbated prognostic parameters and suppressed streptonigrin/cisplatin-induced apoptosis in human cervical cancer (CaCx) cells...
August 29, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28894377/hpip-a-predictor-of-lymph-node-metastasis-and-poor-survival-in-cervical-cancer
#7
Shan Cao, Jingxia Sun, Shuai Lin, Lu Zhao, Di Wu, Tian Liang, Wenji Sheng
BACKGROUND: The aim of this study was to explore the relationships of HPIP expression status with the clinicopathological variables and survival outcomes of patients with cervical cancer (CC). METHODS: We compared the HPIP expression of 119 samples from CC tissues, 20 from cervical intraepithelial tissues, and 20 from normal cervical tissues by using immunohistochemical staining. RESULTS: It was observed that the ratio of elevated HPIP expression was higher in CC tissues than in cervical intraepithelial neoplasia (P=0...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28884382/therapy-free-interval-has-prognostic-value-in-patients-with-recurrent-cervical-cancer-treated-with-chemotherapy-following-definitive-concurrent-chemoradiotherapy
#8
Mitsuru Kozaki, Saki Sakuma, Wataru Kudaka, Yoshino Kinjyo, Yusuke Taira, Yoshihisa Arakaki, Yuko Shimoji, Tadaharu Nakasone, Tomoko Nakamoto, Akihiko Wakayama, Takuma Ooyama, Yoichi Aoki
PURPOSE: Patients with cervical cancer recurrence after concurrent chemoradiotherapy (CCRT) who are not candidates for surgical resection or salvage radiotherapy have a dismal prognosis. The predictive factors for the effects of chemotherapy and prognostic factors in these patients were analyzed. METHODS: We collected data for patients with recurrent cervical cancer who were primarily treated with CCRT between 2000 and 2013. Among them, 57 patients treated with only systemic chemotherapy were analyzed for the overall survival (OS), the overall response rate (ORR), and prognostic factors...
September 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28870908/bcl-2-like-protein-11-bim-expression-is-associated-with-favorable-prognosis-for-patients-with-cervical-cancer
#9
Bo Wook Kim, Hanbyoul Cho, Kris Ylaya, Haruhisa Kitano, Joon-Yong Chung, Stephen M Hewitt, Jae-Hoon Kim
BACKGROUND/AIM: Bcl-2-like protein 11 (BIM) is a pro-apoptotic member of the Bcl-2 protein family. BIM elicits cell death by binding to pro-survival Bcl-2 proteins. Even though the association of BIM expression with cell death has been investigated, its clinical survival significance in cervical cancer has not. In the current study, the prognostic significance of BIM in cervical cancer was investigated. PATIENTS AND METHODS: The study included normal cervical tissues (n=254), cervical intraepithelial neoplasia (CIN) tissues (n=275), and invasive cervical cancer (n=164)...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870055/-lymph-node-metastasis-and-prognostic-factors-for-t1-esophageal-cancer
#10
X F Duan, X B Shang, P Tang, H J Jiang, L Gong, J Yue, M Q Ma, Z T Yu
Objective: To evaluate the lymph node metastasis (LNM) pattern and related prognostic factors for T1 esophageal cancer. Methods: Clinical data of 143 cases of pT1 esophageal cancer patients (120 male and 23 female patients with median age of 60 years) who underwent esophagectomy and lymph node resection during January 2011 and July 2016 at the Department of Esophageal Cancer of Tianjin Medical University Cancer Institute and Hospital were reviewed, including 50 cases of T1a patients and 93 cases of T1b patients...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28860816/ct-guided-125-i-interstitial-brachytherapy-for-pelvic-recurrent-cervical-carcinoma-after-radiotherapy
#11
Lina Tong, Ping Liu, Bin Huo, Zhi Guo, Hong Ni
OBJECTIVE: This retrospective study aimed to evaluate the feasibility, safety, and clinical efficacy of computed tomography (CT)-guided (125)I seed interstitial brachytherapy for pelvic recurrent cervical cancer in patients with a history of pelvic radiotherapy. METHODS: From March 2011 to December 2015, 35 pelvic recurrent lesions (33 patients) were reirradiated using this type of salvage therapy. The medical history, dose-volume histogram parameters, complications, local control, overall survival (OS), and affected factors were analyzed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28859123/prognostic-significance-of-the-co-expression-of-egfr-and-her2-in-adenocarcinoma-of-the-uterine-cervix
#12
Asako Ueda, Akira Takasawa, Taishi Akimoto, Kumi Takasawa, Tomoyuki Aoyama, Yoshihiko Ino, Masanori Nojima, Yusuke Ono, Masaki Murata, Makoto Osanai, Tadashi Hasegawa, Tsuyoshi Saito, Norimasa Sawada
Prognostic factors and therapeutic targets are needed for the patients with cervical adenocarcinoma because they have a poor prognosis. Recently, co-expression of multiple receptor tyrosine kinases (RTKs) has been found to be associated with aggressive biological behavior and poor prognosis of several types of malignancy. To evaluate the significance of the expression of multiple RTKs in uterine cervical cancers, we examined the expression profile of RTKs (EGFR, HER2 and c-Met) and the correlation of their expression with clinicopathological features and prognosis of patients with cervical adenocarcinomas...
2017: PloS One
https://www.readbyqxmd.com/read/28841361/p53r2-overexpression-in-cervical-cancer-promotes-akt-signaling-and-emt-and-is-correlated-with-tumor-progression-metastasis-and-poor-prognosis
#13
Chao Jiang, Rui Xu, Xiao-Xing Li, Yan-Yan Wang, Wen-Qian Liang, Ju-Deng Zeng, Shan-Shan Zhang, Xiao-Yi Xu, Yang Yang, Mei-Yin Zhang, Hui-Yun Wang, X F Steven Zheng
p53R2 is a p53-inducible ribonucleotide reductase subunit involved in deoxyribonucleotide biosynthesis and DNA repair. Although p53R2 has been linked to human cancer, its role in cervical cancer remains unknown. In this study, we investigated the expression and clinical significance of p53R2 in early-stage cervical cancer. p53R2 expression is significantly upregulated at both mRNA and protein levels in cervical cancer cells and tissues, compared with that in matched normal cervical cells and tissues, respectively...
September 17, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28778083/the-prognostic-impact-of-overall-treatment-time-on-disease-outcome-in-uterine-cervical-cancer-patients-treated-primarily-with-concomitant-chemoradiotherapy-a-nationwide-taiwanese-cohort-study
#14
Shih-Min Lin, Hsiu-Ying Ku, Ting-Chang Chang, Tsang-Wu Liu, Ji-Hong Hong
The importance of the overall treatment time (OTT) has a paradoxical status in the current era of concomitant chemoradiotherapy. The main objective of this nationwide study was to evaluate the correlation between overall treatment duration and clinical outcome in cervical cancer patients treated primarily with curative concurrent chemoradiotherapy (CCRT). In this population-based cohort study, 2,594 patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I-IVA uterine cervical cancer were studied...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28774279/pretreatment-glycemic-control-status-is-an-independent-prognostic-factor-for-cervical-cancer-patients-receiving-neoadjuvant-chemotherapy-for-locally-advanced-disease
#15
Jing Li, Ni-Ya Ning, Qun-Xian Rao, Rong Chen, Li-Juan Wang, Zhong-Qiu Lin
BACKGROUND: To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer (LACC). METHODS: A retrospective cohort study was conducted to examine LACC patients undergoing NACT and radical hysterectomy between 2002 and 2011. Patients were divided into three groups: patients without diabetes mellitus (DM), diabetic patients with good glycemic control, and diabetic patients with poor glycemic control...
August 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28763329/efficacy-of-modified-dose-dense-paclitaxel-in-recurrent-cervical-cancer
#16
Hiroko Machida, Aida Moeini, Marcia A Ciccone, Sayedamin Mostofizadeh, Tsuyoshi Takiuchi, Laurie L Brunette, Lynda D Roman, Koji Matsuo
OBJECTIVE: To examine survival outcomes of women with recurrent cervical cancer who received salvage chemotherapy with modified dose-dense paclitaxel (MDDP) monotherapy (paclitaxel 80 mg/m, administered on day 1, 8, and 15 without day 22). MATERIALS AND METHODS: A retrospective study was conducted to evaluate cause-specific survival after the first recurrence (SAR) of women with recurrent cervical cancer diagnosed between 2006 and 2014. Pooled analyses were performed to examine SAR in women who received MDDP monotherapy (n=17) for any treatment line, compared with those who received salvage chemotherapy with paclitaxel-doublet (n=18) and nonpaclitaxel regimens (n=52)...
July 31, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28762954/comparison-of-clinical-utilities-of-the-platelet-count-and-platelet-lymphocyte-ratio-for-predicting-survival-in-patients-with-cervical-cancer-a-single-institutional-study-and-literature-review
#17
Katsumi Kozasa, Seiji Mabuchi, Naoko Komura, Eriko Yokoi, Kuroda Hiromasa, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Eiji Kobayashi, Tadashi Kimura
OBJECTIVE: To compare the clinical utilities of the platelet count and platelet-lymphocyte ratio (PLR) for predicting survival in patients with cervical cancer. RESULTS: Multivariate analyses demonstrated that thrombocytosis and elevated PLR were found to be independent prognostic factors for progression-free survival (PFS, P = 0.0077, P = 0.044) and overall survival (OS, P = 0.025, P = 0.019) in separate Multivariate analyses. In the ROC analysis, the platelet count showed a significantly greater area under the ROC curve (AUC) value than that of PLR for predicting patient recurrence (0...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28761376/the-impact-of-examined-lymph-node-count-on-survival-in-squamous-cell-carcinoma-and-adenocarcinoma-of-the-uterine-cervix
#18
Juan Zhou, Wen-Wen Zhang, San-Gang Wu, Zhen-Yu He, Jia-Yuan Sun, Yan Wang, Qiong-Hua Chen
INTRODUCTION: The prognostic impact of the number of examined lymph nodes (ELNs) in different histological subtypes of cervical cancer remains unclear. We aimed to assess the impact of the number of ELNs in stage IA2-IIA cervical cancer with different histological subtypes. METHODS: Data of patients with stage IA2-IIA squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the uterine cervix between 1988 and 2013 were retrieved from the Surveillance, Epidemiology, and End Results program...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28760449/tumor-microenvironment-determines-response-to-a-heat-activated-thermosensitive-liposome-formulation-of-cisplatin-in-cervical-carcinoma
#19
Yannan N Dou, Naz Chaudary, Martin C Chang, Michael Dunne, Huang Huang, David A Jaffray, Michael Milosevic, Christine Allen
Significant heterogeneity in the tumor microenvironment of human cervical cancer patients is known to challenge treatment outcomes in this population. The current standard of care for cervical cancer patients is radiation therapy and concurrent cisplatin (CDDP) chemotherapy. Yet this treatment strategy fails to control loco-regional disease in 10-30% of patients. In order to improve the loco-regional control rate, a thermosensitive liposome formulation of CDDP (HTLC) was developed to increase local concentrations of drug in response to mild hyperthermia (HT)...
July 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28753926/the-prostaglandin-ep3-receptor-is-an-independent-negative-prognostic-factor-for-cervical-cancer-patients
#20
Helene Heidegger, Sebastian Dietlmeier, Yao Ye, Christina Kuhn, Aurelia Vattai, Caroline Aberl, Udo Jeschke, Sven Mahner, Bernd Kost
We know that one of the main risk factors for cervical cancer is an infection with high-risk human papillomavirus (HR-HPV). Prostaglandins and their receptors are very important for the tumour growth and tumour-associated angiogenesis. Little is known about the expression of the Prostaglandin E receptor type 3 (EP3) or the Prostaglandin (PG)E₂-EP3 signalling in cervical cancer, so the aim of the study was to analyse the expression of the EP3 receptor in cervical cancer and find prognostic factors in relation to survival; EP3 immunohistological staining of 250 cervical cancer slides was performed and analysed with a semi-quantitative score...
July 19, 2017: International Journal of Molecular Sciences
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