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Prognostic factors in cervical cancer

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https://www.readbyqxmd.com/read/29774091/sensitive-molecular-detection-of-small-nodal-metastasis-in-uterine-cervical-cancer-using-hpv16-e6-ck19-muc1-cancer-biomarkers
#1
Vanessa Samouëlian, Nawel Mechtouf, Eric Leblanc, Guillaume B Cardin, Valérie Lhotellier, Denis Querleu, Françoise Révillion, Francis Rodier
Metastatic nodal involvement is a critical prognostic factor in uterine cervical cancer (UCC). To improve current methods of detecting UCC metastases in lymph nodes (LNs), we used quantitative PCR (qPCR) to assess mRNA expression of potential metastatic biomarkers. We found that expression of HPV16-E6, cytokeratin19 (CK19), and mucin1 (MUC1) is consistently upregulated in tumors and metastatic tissues, supporting a role for these genes in UCC progression. These putative biomarkers were able to predict the presence of histologically positive metastatic LNs with respective sensitivities and specificities of 82% and 99% (CK19), 76% and 95% (HPV16-E6), and 76% and 78% (MUC1)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764015/-treatment-and-prognosis-of-264-patients-with-hypopharyngeal-carcinoma
#2
W Xu, Z H Lyu, N Sa, J K Ma, J J Tian, S H Feng, P Cui, H Y Cao
Objective: To investigate the key factors influencing the prognosis of hypopharyngeal carcinoma and the therapeutic methods improving the efficacy of treatments for hypopharyngeal carcinoma. Methods: Two hundred and sixty-four cases of hypopharyngeal squamous cell carcinoma treated from May 2010 to May 2015 were analyzed retrospectively. There were 211 cases of pyriform sinus carcinoma, 37 cases of posterior pharyngeal wall carcinoma, and 16 cases of postcricoid carcinoma. According to UICC 2002 criteria, 2 cases were for stage Ⅰ, 14 for stage Ⅱ, 32 for stage Ⅲ and 216 for stage Ⅳ...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29758203/pretreatment-neutrophil-lymphocyte-and-platelet-lymphocyte-ratio-predict-clinical-outcome-and-prognosis-for-cervical-cancer
#3
MeiLin Zhu, Min Feng, Fei He, BangCai Han, Ke Ma, XinYu Zeng, ZhiRong Liu, XinLian Liu, Juan Li, Hui Cao, YunDan Liang, Cui Jia, LuShun Zhang
Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome in various malignancies. In this study, we aimed to evaluate the predictive and prognostic role of the pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in cervical cancer. We retrospectively investigated 616 patients who underwent initial radical hysterectomy with pelvic lymphadenectomy for cervical cancer between July 2012 and December 2014 in China. Their clinical and histopathological markers and complete blood counts were obtained and analyzed...
May 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29758011/invasion-related-factors-as-potential-diagnostic-and-therapeutic-targets-in-oral-squamous-cell-carcinoma-a-review
#4
REVIEW
Samadarani B S M Siriwardena, Takaaki Tsunematsu, Guangying Qi, Naozumi Ishimaru, Yasusei Kudo
It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)-the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29757873/management-of-vertebral-metastasis-in-patients-with-uterine-cervical-cancer
#5
Mustafa Kocaer, Varol Gülseren, İsa Aykut Özdemir, Özgü Güngördük, Emre Merter Mart, Muzaffer Sanci, Kemal Güngördük
AIM: We sought to identify risk factors and management options for uterine cervical cancer (UCC) patients with a vertebral metastasis (VM) treated over the course of 23 years. METHODS: Among 844 UCC patients, 18 were diagnosed with a VM. Thirty-six control patients with UCC but without recurrence were matched to these 18 in terms of stage and histological tumor type using a dependent random sampling method. A logistic regression analysis was used to identify factors prognostic of VM; the results are presented as odds ratios with 95% confidence intervals (CIs)...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29755594/perineural-invasion-in-early-stage-cervical-cancer-and-its-relevance-following-surgery
#6
Yi Zhu, Guonan Zhang, Yan Yang, Ling Cui, Shijun Jia, Yu Shi, Shuiqin Song, Shiqiang Xu
Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that has attracted attention as a novel prognostic factor for cancer. The present study aimed to investigate the prognostic value of PNI in patients with early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2-IIA). A total of 210 patients who underwent radical hysterectomy and pelvic lymphadenectomy between 2007 and 2012 were included in the current study, of whom 8.57% (18/210) exhibited PNI...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29747270/-prognostic-analysis-of-stage-%C3%A2-b2-and%C3%A2-a2-cervical-squamous-cancer-without-high-risk-factors-treated-with-neo-adjuvant-chemotherapy-and-radical-hysterectomy
#7
P P Li, B Li, Y T Wang, S H Liu, Y N Zhang, R Zhang, P Bai, X G Li, L Y Wu
Objective: To analyze the prognosis of Ⅰb2 and Ⅱa2 cervical squamous cancer without high risk factors treated with neo-adjuvant chemotherapy (NACT) and radical hysterectomy. Methods: This retrospective study included patients with International Federation of Gynecology and Obstetrics (FIGO) stage Ⅰ b2 and Ⅱ a2 cervical squamous cancer without high risk factors who underwent platinum-based NACT followed by radical surgery from January 2008 to January 2015. The responses of NACT were observed and compared in their effect on postoperative pathologic risk factors...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29736362/preoperative-elevated-platelet-count-as-a-prognostic-factor-in-vulvar-squamous-cell-cancer-a-mini-review
#8
REVIEW
Ahmed Abu-Zaid, Osama Alomar, Hany Salem
Preoperative thrombocytosis has been shown to be a marker of advanced disease and poor survival in gynecologic malignancies, specifically endometrial, ovarian, and cervical cancers. The aim of this study is to provide a focused mini-review on all the existing literature concerning the role of preoperative thrombocytosis as a prognostic factor in vulvar squamous cell cancer (SCC). A PubMed search (until February 20, 2018) of all peer-reviewed and English-published articles was conducted using the following keywords: platelet, thrombocytosis, and vulvar cancer...
March 6, 2018: Curēus
https://www.readbyqxmd.com/read/29731822/cbx3-hp1%C3%AE-is-upregulated-in-tongue-squamous-cell-carcinoma-and-is-associated-with-an-unfavorable-prognosis
#9
Huayong Zhang, Xiaoyan Fu, Xuan Su, Ankui Yang
Increased expression of CBX3/HP1γ, a core component of heterochromatin protein 1, has recently proved to be involved in human tumorigenesis and patient prognosis. The present study aimed to investigate the expression of CBX3/HP1γ and its clinicopathological significance in primary tongue squamous cell carcinoma (TSCC). Gene expression profiles of CBX3/HP1γ in TSCC from Oncomine database were analyzed. The expression of CBX3/HP1γ at protein level was measured using immunohistochemistry (IHC). The potential associations between CBX3/HP1γ expression and multiple clinicopathological parameters were estimated using the Chi square test...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29728261/melanoma-of-the-lower-genital-tract-prognostic-factors-and-treatment-modalities
#10
REVIEW
Angiolo Gadducci, Silvestro Carinelli, Maria Elena Guerrieri, Giovanni Damiano Aletti
Primary melanomas originating from the gynecological tract are rare and aggressive cancers. The vulva is the most frequent site (70%), followed by vagina and more rarely by cervix. The clinical outcome of patients with female genital tract melanoma is very poor, with a 5-year overall survival (OS) of 37-50% for vulvar, 13-32% for vaginal, and approximately 10% for cervical melanoma. In this systematic review, we analyzed the pathogenesis and the different factors influencing the prognosis of melanomas of the lower genital tract, with particular emphasis on biologic variables that may influence new therapeutic approaches...
May 1, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29727352/role-of-extensive-lymphadenectomy-in-early-stage-cervical-cancer-patients-with-radical-hysterectomy-followed-by-adjuvant-radiotherapy
#11
Natsuo Tomita, Mika Mizuno, Shinji Kondo, Masahiko Mori, Sho Takeshita, Jun Sakata, Hirofumi Tsubouchi, Takeshi Kodaira
OBJECTIVES: The objective of this study was to assess the effect of extensive lymphadenectomy on survival of early-stage cervical cancer patients with radical hysterectomy followed by adjuvant radiotherapy (RT). MATERIALS AND METHODS: A retrospective analysis was performed on early-stage patients with high-risk factors who received radical hysterectomy with lymphadenectomy followed by adjuvant RT. All patients were divided into the less than or equal to 40 dissected pelvic lymph nodes (DPLN ≤40) and greater than 40 dissected pelvic lymph nodes (DPLN >40) groups to assess the effect of extensive lymphadenectomy...
April 30, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29720427/up-regulation-of-inflammation-related-lncrna-il7r-predicts-poor-clinical-outcome-of-patients-with-cervical-cancer
#12
Yangyang Fan, Yan Nan, Juanjuan Huang, Hui Zhong, Weidong Zhou
The long-term chronic inflammation of cervical intraepithelial neoplasia (CIN) induces the initiation and progression of cervical cancer. Long non-coding RNAs (LncRNAs) are being identified to be involved into inflammation and carcinogenesis and could function as cancer biomarkers in clinical. However, the significance of inflammation-related LncRNA (e.g. LncRNA-IL7R) in cervical cancer is limited. We here investigated the clinical role of inflammation-related LncRNA-IL7R (Lnc-IL7R) in healthy cervical tissue (n=15), CIN 1/2/3 (n=35), cervical cancer (n=70), and clarified its function via knockdown in vitro and in vivo The results showed that the expression of Lnc-IL7R was increased from normal tissues to neoplastic lesions and cervical cancer...
May 2, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29703026/acquired-treatment-response-from-neoadjuvant-chemotherapy-predicts-a-favorable-prognosis-for-local-advanced-cervical-cancer-a-meta-analysis
#13
Yunshan Zhu, Jianhua Yang, Xiao Zhang, Danxia Chen, Songying Zhang
BACKGROUND: Local advanced cervical cancer (LACC) is a considerable health crisis for women, and neoadjuvant chemotherapy (NACT) followed by radical surgery has been a suggested therapy method. However, the correlation between the tumor treatment response to NACT and the prognosis of LACC remains controversial. METHODS: A comprehensive meta-analysis was performed to precisely assess the prognostic role of the clinical response and pathological response to NACT for LACC...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696064/long-term-survival-following-neoadjuvant-chemotherapy-and-concomitant-radiochemotherapy-in-locally-advanced-cervical-cancer-results-of-the-oncology-institute-prof-dr-ion-chiricuta-experience
#14
Andreea Marita, Claudia Ordeanu, Alin Rancea, Todor Nicolae, Viorica-Magdalena Nagy
Objective: to analyze the efficiency of (NACT) followed by concurrent radiochemotherapy (RCT) in patients with locally advanced cervical cancer, 5-year overall, specific and disease-free survival and the prognostic factors correlated with the response and survival. Materials and methods: 207 patients with cervical carcinoma stages IIB-IIIB, who received 2-4 cycles of neoadjuvant chemotherapy followed by concurrent chemoradiation were retrospectively analyzed for an objective response (OR), overall survival (OS), and disease-specific survival (DSS) rate...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#15
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29671552/cervical-cancer-evaluation-and-management
#16
Jennifer Wipperman, Tara Neil, Tracy Williams
Human papillomavirus infection is the precursor for the development of cervical cancer and is detectable in 99.7% of squamous cell carcinoma and adenocarcinoma cases. Early detection of precancerous lesions with Papanicolaou testing remains the primary mechanism for cancer prevention. Once cervical cancer is diagnosed, treatment may involve surgery, radiation therapy, chemotherapy, or a combination. The choice of therapy depends on the stage of disease, lymph node involvement, patient comorbidities, and risk factors for recurrence...
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671223/laparoscopic-paraaortic-surgical-staging-in-locally-advanced-cervical-cancer-a-single-center-experience
#17
D Vázquez-Vicente, B Fernández Del Bas, J García Villayzán, H A Di Fiore, J Luna Tirado, V Casado Echarren, J García-Foncillas, J Plaza Arranz, L Chiva
BACKGROUND: One aim of this study was to assess the efficacy and safety of laparoscopic paraaortic lymphadenectomy for paraaortic lymph node staging in locally advanced cervical carcinoma. The second aim was to identify prognostic factors in the evolution of this disease and to evaluate how the results of the surgery modify the oncological treatment of patients. MATERIALS AND METHODS: We analyzed 59 patients diagnosed with locally advanced cervical cancer International Federation of Gynecology and Obstetrics stage IB2-IVA who underwent laparoscopic paraaortic lymphadenectomy at our hospital between 2009 and 2015...
April 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29670400/-anln-functions-as-a-key-candidate-gene-in-cervical-cancer-as-determined-by-integrated-bioinformatic-analysis
#18
Leilei Xia, Xiaoling Su, Jizi Shen, Qi Meng, Jiuqiong Yan, Caihong Zhang, Yu Chen, Han Wang, Mingjuan Xu
Background: Cervical cancer, one of the leading causes of female deaths, remains a top cause of mortality in gynecologic oncology and tends to affect younger individuals. However, the pathogenesis of cervical cancer is still far from clear. Given the high incidence and mortality of cervical cancer, uncovering the causes and pathogenesis as well as identifying novel biomarkers are of great significance and are desperately needed. Materials and methods: First, raw data were downloaded from the Gene Expression Omnibus database...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29668638/clinical-impact-of-boost-irradiation-to-pelvic-lymph-node-in-uterine-cervical-cancer-treated-with-definitive-chemoradiotherapy
#19
Kyu Hye Choi, Ji Yoon Kim, Dong Soo Lee, Yun Hee Lee, Sea-Won Lee, SooYoon Sung, Hee Hyun Park, Sei-Chul Yoon, Soo Young Hur, Jong-Sup Park, Yeon Sil Kim
The aim of this study was to analyze tumor control and clinical outcomes of patients with uterine cervical cancer treated by chemoradiotherapy according to pelvic lymph node (PLN) positivity and boost irradiation to PLN and to determine toxicities associated with boost irradiation.We retrospectively reviewed patients with uterine cervical cancer treated with chemoradiotherapy between March 2000 and April 2015. Clinical characteristics, failure pattern, and survival outcomes of patients with or without PLN metastasis and those with or without boost irradiation were analyzed...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29662648/visceral-abdominal-fat-measured-by-computer-tomography-as-a-prognostic-factor-for-gynecological-malignancies
#20
Johanna Nattenmüller, Joachim Rom, Tom Buckner, Jalal Arvin, Benedikt Bau, Christof Sohn, Hans-Ulrich Kauczor, Sarah Schott
Introduction: Obesity is associated with increased incidence of ovarian (OC), cervical (CC) and endometrium cancer (EC). However, the impact of body composition (BC) on overall survival (OS), especially of visceral adipose tissue (VAT) is not yet understood. Methods: In 189 women with gynecological malignancies (31 OC, 104 CC, 54 EC, mean age 62.9y; mean BMI 26.8 kg/m2 ; median follow-up 30.7months) with routine staging CT-scans at baseline (mean interval: 4.3 months), densitometric quantification of total (TAT), visceral, and subcutaneous-fat-area (SAT), inter-muscular-fat-area (IMFA), and skeletal-muscle-index (SMI) was performed to analyze the impact of BC on survival...
March 27, 2018: Oncotarget
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