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Syphilis IgG

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https://www.readbyqxmd.com/read/28899886/brainstem-encephalitis-and-acute-polyneuropathy-associated-with-hepatitis-e-infection
#1
Omar Jabbar Salim, Amy Davidson, Kathy Li, John Paul Leach, Craig Heath
A 59-year-old man presented with feverish illness. His Glasgow Coma Scale was 15, had reduced visual acuity in the left eye with partial left ptosis and mild left hemiparesis with an extensor left plantar. Over 48 hours, he accrued multiple cranial nerves palsies and progressed to a flaccid paralysis necessitating admission to an intensive care unit.Cerebrospinal fluid (CSF) study showed 20 lymphocytes and raised protein. Viral and bacterial PCRs were negative. Samples for Lyme, blood-borne viruses, syphilis and autoantibodies were also negative...
September 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28878003/evaluation-of-the-lumipulse%C3%A2-g-tp-n-chemiluminescent-immunoassay-as-a-syphilis-screening-test
#2
Daniel A Ortiz, Michael J Loeffelholz
A syphilis diagnosis is often aided by the detection of treponemal and non-treponemal antibodies. Automated treponemal antibody detection systems enable high-volume clinical laboratories to perform syphilis screening at a faster pace with lower labor costs. The Lumipulse G TP-N chemiluminescent immunoassay is an automated system that qualitatively detects IgG and IgM antibodies against Treponema pallidum antigens in human serum and plasma. To assess performance characteristics and workflow efficiency, the Lumipulse G TP-N assay was compared to the Bioplex 2200 Syphilis IgG multiplex flow immunoassay...
September 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28856228/traditional-versus-reverse-syphilis-algorithms-a-comparison-at-a-large-academic-medical-center
#3
Craig D Dunseth, Bradley A Ford, Matthew D Krasowski
OBJECTIVES: An increasing number of institutions are transitioning from the traditional syphilis testing algorithm (initial screening with nontreponemal tests) to the 'reverse' algorithm (initial screening with treponemal tests such as syphilis IgG). The aim of this study was to evaluate the switch in syphilis algorithm at an academic medical center with a population with low syphilis prevalence. DESIGN AND METHODS: We performed a six-year retrospective study at the University of Iowa Hospitals and Clinics, an academic medical center, comparing the traditional algorithm (n=12,612) with the reverse algorithm (n=10,453)...
August 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28812057/screening-for-syphilis-in-cases-of-suspected-gonorrhea-and-chlamydia-infections
#4
Kumara V Nibhanipudi, Kenneth Cody
Background. In all cases of suspected sexually transmitted infections (STIs), it has been routine practice to screen for syphilis with a blood sample. The incidence of syphilis seems to be lower than that of commonly screened STIs. Objective. The objective of our study was to determine whether it is cost-effective to screen for syphilis with serological testing in cases of suspected gonorrhea and chlamydia infections. Hypothesis. Our hypothesis is that it is not cost-effective to screen for syphilis in cases of presumed gonorrhea and chlamydia infections...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28792374/evaluation-of-an-automated-quantitative-latex-immunoturbidimetric-non-treponemal-assay-for-diagnosis-and-follow-up-of-syphilis-a-prospective-cohort-study
#5
Kara Osbak, Said Abdellati, Achilleas Tsoumanis, Marjan Van Esbroeck, Luc Kestens, Tania Crucitti, Chris Kenyon
PURPOSE: We evaluated the Sekure rapid plasma reagin (RPR-S) (Sekisui Diagnostics) automated quantitative latex immunoturbidimetric assay performed on the SK500 clinical chemistry system for clinical appropriateness. METHODOLOGY: Syphilis-infected individuals and controls were recruited into a prospective cohort study conducted at a sexually transmitted infection clinic in Antwerp, Belgium. Sera collected at diagnosis (baseline) and at 3, 6, 9 and 12 months post-treatment were tested with RPR-S and Macro-Vue RPR card (RPR-C) (Becton Dickinson) assays; RPR-C was considered the reference test...
August 10, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28583150/prevalence-of-pregnancy-relevant-infections-in-a-rural-setting-of-ghana
#6
Fabian Völker, Paul Cooper, Oliver Bader, Angela Uy, Ortrud Zimmermann, Raimond Lugert, Uwe Groß
BACKGROUND: Although infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal and child health are missing. METHODS: We conducted a cross-sectional, single-centre pilot study in a rural area of Ghana to assess the infectiological profile during pregnancy. Screening of 180 expectant mothers was done by vaginal swabs and serology to detect the most common pregnancy-relevant infections...
June 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28397205/assessment-of-the-implementation-of-the-infectious-diseases-screening-programmes-among-pregnant-women-in-the-lesser-poland-region-and-comparison-with-similar-programmes-conducted-in-other-european-union-countries
#7
Małgorzata Radoń-Pokracka, Maciej Piasecki, Alicja Lachowska, Sebastian Baczkowski, Joanna Spaczyńska, Magdalena Górecka, Magdalena Nowak, Hubert Huras
OBJECTIVES: The aim of the study was to assess the level of implementation of recommendations of the Ministry of Health regarding infectious disease screening during pregnancy. MATERIAL AND METHODS: The study included 477 patients who were admitted to the delivery room between December 2015 and February 2016. Data on screening test results were collected based on medical records covering the period before the admission. RESULTS: The Human Immunodeficiency Virus (HIV) screening was conducted in 410 (86%)...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28056870/anti-n-methyl-d-aspartate-receptor-nmdar-antibody-encephalitis-presents-in-atypical-types-and-coexists-with-neuromyelitis-optica-spectrum-disorder-or-neurosyphilis
#8
Kaiyu Qin, Wenqing Wu, Yuming Huang, Dongmei Xu, Lei Zhang, Bowen Zheng, Meijuan Jiang, Cheng Kou, Junhua Gao, Wurong Li, Jinglin Zhang, Sumei Wang, Yanfei Luan, Chaoling Yan, Dan Xu, Xinmei Zheng
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases of anti-NMDAR encephalitis with incomplete forms, 3 cases of which were accompanied by neuromyelitis optica spectrum disorder or neurosyphilis respectively. CASE PRESENTATION: A 33-year-old man presented with dysarthria, movement disorder and occasional seizures...
January 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/27835625/use-of-treponemal-screening-assay-strength-of-signal-to-avoid-unnecessary-confirmatory-testing
#9
Gregory J Berry, Michael J Loeffelholz
BACKGROUND: Our reverse syphilis testing algorithm consists of a treponemal IgG multiplex flow immunoassay (MFI) followed by both rapid plasma reagin titer and the Treponema pallidum particle agglutination (TPPA) test on specimens with a reactive MFI result. We report here the impact of a modified reverse algorithm, in which the strength of signal of the MFI is used to avoid unnecessary TPPA testing. METHODS: The Bioplex syphilis IgG MFI was used as the syphilis screening assay, and specimens with equivocal (antibody index 0...
December 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27622800/seroprevalence-of-human-t-lymphotropic-virus-in-blood-bank-donors-at-fundaci%C3%A3-n-valle-del-lili-cali-colombia-2008-2014
#10
Carmenza Macía, Sandra Vargas, Ana María Mora, Ashly Melissa Sarmiento, Robinson Pacheco, Fernando Rosso
INTRODUCTION: Human lymphotropic virus (HTLV I/II) is a retrovirus that is prevalent across the Colombian Pacific coast, and is potentially transmissible by transfusion. Blood bank screening has been regulated since 2004, in order to reduce transmission of HTLV I/II through donation. Information on the seroprevalence of the virus in southwestern Colombia is limited.  OBJECTIVE: To determine the seroprevalence and the behavior of reactivity to HTLV I/II before and after the introduction of Western blot, and the comorbidity of HTLV and other infectious markers in donors from a blood bank in Cali, Colombia...
February 11, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27558164/first-report-of-tertiary-syphilis-presenting-as-lipoatrophic-panniculitis-in-an-immunocompetent-patient
#11
Francesco Drago, Giulia Ciccarese, Carlo F Tomasini, Paola Calamaro, Maurizio Boggio, Alfredo Rebora, Aurora Parodi
We describe herein a woman who developed subcutaneous gummas in her trochanteric regions, bilaterally, although she had been treated for syphilis two decades earlier. Evidence of Treponema pallidum latent late infection was the presence of IgG antibodies against T. pallidum and the positive non-treponemal and treponemal tests. Moreover, immunohistochemical staining for T. pallidum detected some spirochetes close to the atrophic adipocytes allowing the diagnosis of lypo-atrophic panniculitis tertiary syphilis...
August 24, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27509513/increasing-hiv-incidence-among-men-who-have-sex-with-men-in-jiangsu-province-china-results-from-five-consecutive-surveys-2011-2015
#12
Haiyang Hu, Xiaoyan Liu, Zhi Zhang, Xiaoqin Xu, Lingen Shi, Gengfeng Fu, Xiping Huan, Ying Zhou
Epidemics of HIV among men who have sex with men (MSM) are major public health concerns in most parts of China. This study examined the trends in HIV incidence and associated factors among MSM in Jiangsu Province. Five consecutive cross-sectional surveys were conducted among MSM from 2011 to 2015 in eight cities throughout Jiangsu Province. Participants were recruited from MSM venues or via the internet. Demographic and behavioral data were collected through HIV bio-behavioral surveys. Blood specimens were collected to test for HIV and syphilis...
August 6, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27448458/feasibility-of-a-simple-microsieve-based-immunoassay-platform
#13
Daniel R Zweitzig, Arjan G Tibbe, Ai T Nguyen, Cees J M van Rijn, Mark J Kopnitsky, Kathleen Cichonski, Leon W M M Terstappen
The intrinsic properties of silicon microsieves, such as an optically flat surface, high overall porosity, and low flow resistance have led to an increasing number of biotechnology applications. In this report, the feasibility of creating a microsieve-based immunoassay platform was explored. Microsieves containing 5μm pores were coupled with poly-acrylic acid chains, and then mounted into a plastic holder to enable rapid reagent exchanges via a wicking mechanism. The mounted microsieves were coated with infectious disease-related antigens at [2...
October 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27353706/evaluation-of-six-recombinant-proteins-for-serological-diagnosis-of-lyme-borreliosis-in-china
#14
Wei Liu, Hui Xin Liu, Lin Zhang, Xue Xia Hou, Kang Lin Wan, Qin Hao
OBJECTIVE: In this study, we evaluated the diagnostic efficiency of six recombinant proteins for the serodiagnosis of Lyme borreliosis (LB) and screened out the appropriate antigens to support the production of a Chinese clinical ELISA (enzyme-linked immunosorbent assay) kit for LB. METHODS: Six recombinant antigens, Fla B.g, OspC B.a, OspC B.g, P39 B.g, P83 B.g, and VlsE B.a, were used for ELISA to detect serum antibodies in LB, syphilis, and healthy controls. The ELISA results were used to generate receiver operating characteristic (ROC) curves, and the sensitivity and specificity of each protein was evaluated...
May 2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27215069/performance-evaluation-of-a-novel-chemiluminescence-assay-detecting-treponema-pallidum-antibody-as-a-syphilis-screening-method
#15
Qixia Chen, Jingna An, Chenli Rao, Tingting Wang, Dongdong Li, Shu Feng, Chuanmin Tao
BACKGROUND: Syphilis is a major concern to global public health with increasing incidence. So its screening test should have sufficient sensitivity and specificity. We evaluated the performance of the Lumipulse G TP-N assay detection for syphilis screening and compared it with the InTec ELISA test kit for TP, which is widely used. METHODS: Samples of several patient groups including 133 clinical and serologically characterized syphilitic sera, 175 samples containing potentially interfering agents, and 2290 unselected samples submitted for routine screening were detected by both the Lumipulse G TP-N assay and the InTec ELISA test kit for TP...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27152908/application-of-goldmag-immune-probe-in-timely-detection-of-syphilis-based-on-gis-platform
#16
Zhong Tang, Zhisheng Liang, Yi Nong, Xiaochun Wu, Hui Luo, Kun Gao
The purpose of this study was to apply goldmag immunoprobes into establishment of nanoparticles-based colorimetric assay as well as construction of immunochromatography quantitative and qualitative system by exploring point-of-care testing of syphilis with goldmag particles carrier-based immunoprobe and analysis of spatial data of Geographic Information System (GIS) platform. Goat anti-rabbit immunoglobulin G (IgG) was coupled on the surface of modified nanoparticles, taking N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide as the connector...
May 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27151014/-relationship-between-m-protein-of-multiple-myeloma-and-false-positive-syphilis-serological-results
#17
Tao-Jun He, Fan Mo, Xiao-You Xiao, Qiao-Yun Dan, Su-Jie Li, Yin-Hui Zhang, Xue-Dong Lu
BACKGROUND: The false positive in conventional syphilis serological test was found in patients with multiple myeloma (MM). OBJECTIVE: To investigate the relationship between the M-protein of patients with MM and the false positive in conventional syphilis serologic test. METHODS: The M-protein of 68 MM cases was typed with immunofixation electrophoresis and 68 cases of MM were screened with non-specific and specific syphilis serologic tests, then the samples with syphilic serological positive were chosen and confirmed with immonobloting test, finally the relationship between M protein of MM and the false positive of syphilis serological test were analysed...
April 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/26982990/cerebrospinal-fluid-examination-may-be-useful-in-diagnosing-neurosyphilis-in-asymptomatic-hiv-patients-with-syphilis
#18
Ronald Salamano, Raquel Ballesté, Abayubá Perna, Natalia Rodriguez, Diego Lombardo, Natalia García, Pablo López, Pablo Cappuccio
Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity...
February 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/26961856/contribution-of-a-comparative-western-blot-method-to-early-postnatal-diagnosis-of-congenital-syphilis
#19
COMPARATIVE STUDY
Antonella Marangoni, Claudio Foschi, Maria Grazia Capretti, Paola Nardini, Monica Compri, Luigi Tommaso Corvaglia, Giacomo Faldella, Roberto Cevenini
Serology has a pivotal role in the diagnosis of congenital syphilis (CS), but problems arise because of the passive transfer of IgG antibodies across the placenta. The aim of this study was to assess the diagnostic value of a comparative Western blot (WB) method finalized to match the IgG immunological profiles of mothers and their own babies at birth in order to differentiate between passively transmitted maternal antibodies and antibodies synthesized by the infants against Treponema pallidum Thirty infants born to mothers with unknown or inadequate treatment for syphilis were entered in a retrospective study, conducted at St...
May 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/26853900/diagnostic-value-of-recombinant-tp0821-protein-in-serodiagnosis-for-syphilis
#20
Y Xie, M Xu, C Wang, J Xiao, Y Xiao, C Jiang, X You, F Zhao, T Zeng, S Liu, X Kuang, Y Wu
UNLABELLED: Syphilis is a multistage sexually transmitted disease that remains a serious public health concern worldwide. The coexistence of Treponema pallidum with other closely related members of spirochaeta, such as Leptospira spp. and Borrelia burgdorferi, has complicated the serodiagnosis due to cross-reactive antigens. In this study, recombinant Tp0821 protein was expressed in Escherichia coli and purified by metal affinity chromatography. Then enzyme-linked immunosorbent assays (ELISAs) based on Tp0821 for the detection of specific antibodies were established...
April 2016: Letters in Applied Microbiology
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