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https://www.readbyqxmd.com/read/27921454/methods-and-techniques-for-metabolic-phenotyping
#1
Ian Wilson
No abstract text is available yet for this article.
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27920928/-trans-chlorido-2-rp-2-methyl-sulfan-yl-ferro-cen-yl-2-5-6-7-tetra-hydro-pyrrolo-1-2-c-imidazol-3-yl-idene-bis-tri-phenyl-phosphane-%C3%AE%C2%BAp-palladium-ii-hexa-fluorido-phosphate-di-chloro-form-disolvate
#2
Cody Wilson-Konderka, Alan J Lough, Costa Metallinos
The title solvated complex, [FePd(C5H5)(C12H13N2S)Cl(C18H15P)2]PF6·2CHCl3, bearing a chiral ferrocenyl pyrrolo-imidazolyl-idene N-heterocyclic carbene (NHC) ligand, was synthesized by oxidative addition of a chloro-imidazolium salt to Pd(PPh3)4. The Pd(II) ion is coordinated in a slightly distorted square-planar coordination geometry, with the Cl atom trans to the coordinating C atom of the pyrrolo-imidazolyl-idene ligand. The complex features a pendant thio-ether group that is not involved in coordination to Pd...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27920456/total-serum-bilirubin-is-an-independent-risk-factor-for-coronary-artery-disease-in-men-compared-to-women
#3
A Nguyen, H Adams, J Gin, N Yap, A Wilson-O'Brien, J Garlick, A M Wilson
No abstract text is available yet for this article.
2016: Acta Cardiologica
https://www.readbyqxmd.com/read/27920071/estimation-of-risk-for-initial-atherosclerotic-cardiovascular-disease-events-taking-stock-and-moving-forward
#4
Peter W F Wilson, Michael J Pencina
No abstract text is available yet for this article.
December 6, 2016: Circulation
https://www.readbyqxmd.com/read/27919975/long-term-high-quality-survival-with-single-agent-mifepristone-treatment-despite-advanced-cancer
#5
Jerome H Check, Diane Check, Carrie Wilson, Patrice Lofberg
CASE REPORT: We show long-term high-quality survival following single-agent treatment with a progesterone receptor antagonist in two cases of advanced metastatic cancer. Because no biopsy was performed (patient refused) the exact type of lung cancer was not determined but the majority of oncologists who evaluated the patient thought that the rapid onset and syndrome of inappropriate anti-diuretic hormone was more consistent with small-cell lung cancer. The US Food and Drug Association granted a compassionate-use investigational new drug approval for use of single-agent 200 mg mifepristone orally/day to a moribund woman with never-treated metastatic lung cancer and a male with bilateral renal cell carcinoma who had undergone only a unilateral hemi-nephrectomy...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919750/mapping-the-functional-connectome-in-traumatic-brain-injury-what-can-graph-metrics-tell-us
#6
Karen Caeyenberghs, Helena Verhelst, Adam Clemente, Peter H Wilson
OBJECTIVE: Traumatic brain injury (TBI) is associated with cognitive and motor deficits, and poses a significant personal, societal, and economic burden. One mechanism by which TBI is thought to affect cognition and behaviour is through changes in functional connectivity. Graph theory is a powerful framework for quantifying topological features of neuroimaging-derived functional networks. The objective of this paper is to review studies examining functional connectivity in TBI with an emphasis on graph theoretical analysis that is proving to be valuable in uncovering network abnormalities in this condition...
December 2, 2016: NeuroImage
https://www.readbyqxmd.com/read/27919661/a-functional-near-infrared-spectroscopy-study-of-the-effects-of-configural-properties-on-sustained-attention
#7
Neil R de Joux, Kyle M Wilson, Paul N Russell, Kristin M Finkbeiner, William S Helton
Forty-five participants performed a vigilance task during which they were required to respond to a critical signal at a local feature level, while the global display was altered between groups (either a circle, a circle broken apart and reversed, or a reconnected figure). The shape in two of the groups formed a configurative whole (the circle and reconnected conditions), while the remaining shape had no complete global element (broken circle). Performance matched the results found in the previous experiments using this stimulus set, where a configural superiority effect was found to influence accuracy over time...
December 2, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27919416/a-3d-model-of-the-achilles-tendon-to-determine-the-mechanisms-underlying-nonuniform-tendon-displacements
#8
Geoffrey G Handsfield, Joshua M Inouye, Laura C Slane, Darryl G Thelen, G Wilson Miller, Silvia S Blemker
The Achilles is the thickest tendon in the body and is the primary elastic energy-storing component during running. The form and function of the human Achilles is complex: twisted structure, intratendinous interactions, and differential motor control from the triceps surae muscles make Achilles behavior difficult to intuit. Recent in vivo imaging of the Achilles has revealed nonuniform displacement patterns that are not fully understood and may result from complex architecture and musculotendon interactions...
November 28, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27919113/analysis-of-flap-weight-and-postoperative-complications-based-on-flap-weight-in-patients-undergoing-microsurgical-breast-reconstruction
#9
Gretl Lam, Katie E Weichman, Patrick L Reavey, Stelios C Wilson, Jamie P Levine, Pierre B Saadeh, Robert J Allen, Mihye Choi, Nolan S Karp, Vishal D Thanik
Background Higher body mass index (BMI) has been shown to increase postoperative complications in autologous breast reconstruction. However, the correlation with flap weight is unknown. Here, we explore the relationship of flap weights and complication rates in patients undergoing microvascular breast reconstruction. Methods Retrospective chart review identified all patients undergoing microvascular breast reconstruction with abdominally based flaps at a single institution between November 2007 and April 2013...
December 5, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27918881/a-preliminary-investigation-of-a-relapse-prevention-mobile-application-to-maintain-smoking-abstinence-among-individuals-with-posttraumatic-stress-disorder
#10
Terrell A Hicks, Shaun P Thomas, Sarah M Wilson, Patrick S Calhoun, Eric R Kuhn, Jean C Beckham
OBJECTIVES: Smokers with posttraumatic stress disorder (PTSD) have increased difficulty achieving and maintaining abstinence. Contingency management approaches to smoking cessation interventions have demonstrated short-term efficacy, but are limited by high rates of relapse. The goal of this pilot study was to evaluate the usability and feasibility of a smartphone-based smoking cessation application (Stay Quit Coach) designed to prevent relapse among individuals with PTSD. METHODS: Smokers (N = 11) were randomized to 1) QUIT4EVER, an intervention combining mobile contingency management smoking cessation counseling and medications, and Stay Quit Coach or 2) a contact control condition that was identical to QUIT4EVER except Stay Quit Coach was not included...
December 5, 2016: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/27918534/multiethnic-genome-wide-meta-analysis-of-ectopic-fat-depots-identifies-loci-associated-with-adipocyte-development-and-differentiation
#11
Audrey Y Chu, Xuan Deng, Virginia A Fisher, Alexander Drong, Yang Zhang, Mary F Feitosa, Ching-Ti Liu, Olivia Weeks, Audrey C Choh, Qing Duan, Thomas D Dyer, John D Eicher, Xiuqing Guo, Nancy L Heard-Costa, Tim Kacprowski, Jack W Kent, Leslie A Lange, Xinggang Liu, Kurt Lohman, Lingyi Lu, Anubha Mahajan, Jeffrey R O'Connell, Ankita Parihar, Juan M Peralta, Albert V Smith, Yi Zhang, Georg Homuth, Ahmed H Kissebah, Joel Kullberg, René Laqua, Lenore J Launer, Matthias Nauck, Michael Olivier, Patricia A Peyser, James G Terry, Mary K Wojczynski, Jie Yao, Lawrence F Bielak, John Blangero, Ingrid B Borecki, Donald W Bowden, John Jeffrey Carr, Stefan A Czerwinski, Jingzhong Ding, Nele Friedrich, Vilmunder Gudnason, Tamara B Harris, Erik Ingelsson, Andrew D Johnson, Sharon L R Kardia, Carl D Langefeld, Lars Lind, Yongmei Liu, Braxton D Mitchell, Andrew P Morris, Thomas H Mosley, Jerome I Rotter, Alan R Shuldiner, Bradford Towne, Henry Völzke, Henri Wallaschofski, James G Wilson, Matthew Allison, Cecilia M Lindgren, Wolfram Goessling, L Adrienne Cupples, Matthew L Steinhauser, Caroline S Fox
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size-weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six traits associated with ectopic fat (hereinafter referred to as ectopic-fat traits)...
December 5, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27918150/seroprevalence-and-risk-factors-for-leptospira-seropositivity-in-beef-cattle-sheep-and-deer-farmers-in-new-zealand
#12
J M Sanhueza, C Heuer, P R Wilson, J Benschop, J M Collins-Emerson
Leptospirosis is a global zoonosis that in New Zealand affects primarily people occupationally exposed to livestock. The objective of this study was to estimate the seroprevalence of five Leptospira serovars in farmers working on cattle, sheep and deer farms that had the serological status of animals previously assessed and to identify risk factors for farmer seropositivity. A total of 178 farmers from 127 properties participated in the study. Blood samples were tested using the microscopic agglutination test (MAT) for the presence of antibodies to Leptospira...
December 5, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27917569/distinct-intrinsic-functional-brain-network-abnormalities-in-methamphetamine-dependent-patients-with-and-without-a-history-of-psychosis
#13
Jonathan C Ipser, Anne Uhlmann, Paul Taylor, Brian H Harvey, Don Wilson, Dan J Stein
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP)...
December 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27917525/a-comparison-study-of-multivariate-fixed-models-and-gene-association-with-multiple-traits-gamut-for-next-generation-sequencing
#14
Chi-Yang Chiu, Jeesun Jung, Yifan Wang, Daniel E Weeks, Alexander F Wilson, Joan E Bailey-Wilson, Christopher I Amos, James L Mills, Michael Boehnke, Momiao Xiong, Ruzong Fan
In this paper, extensive simulations are performed to compare two statistical methods to analyze multiple correlated quantitative phenotypes: (1) approximate F-distributed tests of multivariate functional linear models (MFLM) and additive models of multivariate analysis of variance (MANOVA), and (2) Gene Association with Multiple Traits (GAMuT) for association testing of high-dimensional genotype data. It is shown that approximate F-distributed tests of MFLM and MANOVA have higher power and are more appropriate for major gene association analysis (i...
December 5, 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/27917518/dental-implant-loss-in-older-versus-younger-patients-a-systematic-review-and-meta-analysis-of-prospective-studies
#15
REVIEW
Daniel Isaac Sendyk, Emanuel da Silva Rovai, Claudio Mendes Pannuti, Maria Cristina Zindel Deboni, Wilson Roberto Sendyk, Ann Wennerberg
The aim of this systematic review was to evaluate implant loss in younger and older patients. An electronic search of four databases (MEDLINE, EMBASE, SCOPUS and the Cochrane Library) was undertaken until May 2016 without time restriction and was supplemented by manual searching. Prospective cohorts were included if they met the following criteria: (1) presence of an exposed group (older subjects) with a minimum age of 60 years; (2) presence of a control group (younger subjects) with a maximum age of 59 years; and (3) outcome data considering implant survival or loss...
December 5, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27917500/an-alloantibody-in-a-homozygous-gyp-mur-individual-defines-jenu-mns49-a-new-high-frequency-antigen-on-glycophorin-b
#16
Genghis H Lopez, Brett Wilson, Yew-Wah Liew, Pawinee Kupatawintu, Morakot Emthip, Catherine A Hyland, Robert L Flower
No abstract text is available yet for this article.
December 4, 2016: Transfusion
https://www.readbyqxmd.com/read/27917200/sero-prevalence-and-associated-factors-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-attending-the-gastroenterology-unit-in-a-tertiary-hospital-in-mwanza-tanzania
#17
Hyasinta Jaka, Martha F Mushi, Mariam M Mirambo, Leonard Wilson, Jeremiah Seni, Majigo Mtebe, Stephen E Mshana
BACKGROUND: Prevalence of H.pylori infection varies greatly between populations in different countries. This study was conducted to determine the magnitude of H.pylori among adult patients with dyspepsia attending the gastroenterology unit at Bugando medical centre. METHODS: A cross sectional study involving 202 dyspeptic patients was conducted between June and July 2014. A Standardized data collection tool was used to collect socio-demographic characteristics. H...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27916927/vitamin-b12-status-among-pregnant-women-in-the-uk-and-its-association-with-obesity-and-gestational-diabetes
#18
Nithya Sukumar, Hema Venkataraman, Sean Wilson, Ilona Goljan, Selvin Selvamoni, Vinod Patel, Ponnusamy Saravanan
BACKGROUND: To evaluate vitamin B12 and folate status in pregnancy and their relationship with maternal obesity, gestational diabetes mellitus (GDM), and offspring birthweight. METHODS: A retrospective case-control study of 344 women (143 GDM, 201 no-GDM) attending a district general hospital and that had B12 and folate levels measured in the early 3rd trimester was performed. Maternal history including early pregnancy body mass index (BMI) and neonatal data (birthweight, sex, and gestational age) was recorded for all subjects...
December 1, 2016: Nutrients
https://www.readbyqxmd.com/read/27916360/combined-resection-and-rfa-in-colorectal-liver-metastases-stratification-of-long-term-outcomes
#19
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Yuhree Kim, Ana Wilson, Faiz Gani, Neda Amini, Timothy M Pawlik
BACKGROUND: Combined hepatic resection and radiofrequency ablation (resection-RFA) is a widely accepted multidisciplinary treatment for unresectable colorectal cancer liver metastases. Worse prognosis after resection-RFA is correlated to tumor morphology, although unfavorable morphology is inherent to this patient cohort. This study aimed to select patients who may or may not benefit from resection-RFA with the aid of tumor biology. METHOD: Data from 485 patients who underwent curative hepatectomy with or without concurrent RFA were retrospectively collected and analyzed...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27915967/liver-transplant-can-resolve-severe-neuropsychiatric-manifestations-of-wilson-disease-a-case-report
#20
Gregory Walker, Trana Hussaini, Robert Stowe, Silke Cresswell, Eric M Yoshida
Although liver transplant for decompensated cirrhosis secondary to Wilson disease is well accepted, the use of transplant for patients with severe neurologic manifestations of this condition remains controversial, and these can be perceived as a contraindication. Here, we describe a 45-year-old woman who presented with an incidental hepatocellular carcinoma at the time of transplant. The patient had severe neurologic manifestations of Wilson disease pretransplant, including dysarthria, hyperreflexia, asymmetrical ataxia, tremor, bradyphrenia, and shuffling gait...
December 2, 2016: Experimental and Clinical Transplantation
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