Kokila Shankar, Sélène Bonnet-Zahedi, Kristel Milan, Andrea Ruiz D'argence, Elizabeth Sneddon, Ran Qiao, Supakorn Chonwattangul, Lieselot Lg Carrette, Marsida Kallupi, Olivier George
Nicotine use produces psychoactive effects, and chronic use is associated with physiological and psychological symptoms of addiction. However, chronic nicotine use is known to decrease food intake and body weight gain, suggesting that nicotine also affects central metabolic and appetite regulation. We recently showed that acute nicotine self-administration in nicotine-dependent animals produces a short-term increase in food intake, contrary to its long-term decrease of feeding behavior. As feeding behavior is regulated by complex neural signaling mechanisms, this study aimed to test the hypothesis that nicotine intake in animals exposed to chronic nicotine may increase activation of pro-feeding regions and decrease activation of pro-satiety regions to produce the acute increase in feeding behavior...
April 20, 2024: Neuropharmacology