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https://www.readbyqxmd.com/read/29929081/decellularized-peripheral-nerve-supports-schwann-cell-transplants-and-axon-growth-following-spinal-cord-injury
#1
Susana R Cerqueira, Yee-Shuan Lee, Robert C Cornelison, Michaela W Mertz, Rebecca A Wachs, Christine E Schmidt, Mary Bartlett Bunge
Schwann cell (SC) transplantation has been comprehensively studied as a strategy for spinal cord injury (SCI) repair. SCs are neuroprotective and promote axon regeneration and myelination. Nonetheless, substantial SC death occurs post-implantation, which limits therapeutic efficacy. The use of extracellular matrix (ECM)-derived matrices, such as Matrigel, supports transplanted SC survival and axon growth, resulting in improved motor function. Because appropriate matrices are needed for clinical translation, we test here the use of an acellular injectable peripheral nerve (iPN) matrix...
May 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29929068/are-hertwig-s-epithelial-root-sheath-cells-necessary-for-periodontal-formation-by-dental-follicle-cells
#2
Yongwen Guo, Weihua Guo, Jie Chen, Guoqing Chen, Weidong Tian, Ding Bai
OBJECTIVE: The role of Hertwig's epithelial root sheath (HERS) cells in periodontal formation has been controversial. This study aimed to further clarify whether HERS cells participate in formation of the periodontium, and the necessity of HERS cells in differentiation of dental follicle cells (DFCs) for periodontal regeneration. DESIGN: HERS cells and DFCs were isolated and identified from post-natal 7-day Sprauge-Dawley rats. In vitro, direct co-culture of HERS cells and DFCs as well as the individual culture of HERS and DFCs were performed and followed by alizarin red staining and the quantitative real-time polymerase chain reaction analysis...
June 18, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29929019/the-rehabilitation-of-advanced-heart-failure-patients-after-left-ventricular-assist-device-a-narrative-review
#3
REVIEW
Sarah M Eickmeyer, Kim D Barker, Anjum Sayyad, Leslie Rydberg
As an increasing number of patients with advanced heart failure are receiving a Left Ventricular Assist Device (LVAD) as either destination therapy or bridge to transplantation, there is increasing attention on functional outcomes and quality of life after LVAD implantation. Rehabilitation providers in the acute inpatient rehabilitation setting increasingly will treat patients with LVAD and should understand the exercise physiology, medical management, rehabilitation considerations, and outcomes after rehabilitation for patients with LVAD...
June 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29928989/-risk-score-for-development-of-veno-occlusive-disease-after-allogeneic-hematopoietic-cell-transplant
#4
Christopher Strouse, Ying Zhang, Mei-Jie Zhang, Alyssa DiGilio, Marcelo Pasquini, Mary M Horowitz, Stephanie Lee, Vincent Ho, Muthalagu Ramanathan, Wichai Chinratanalab, Alison Loren, Linda J Burns, Andrew Artz, Kathleen F Villa, Wael Saber
BACKGROUND: A risk score identifying patients at high risk for veno-occlusive disease (VOD) may aid efforts to study preventive strategies for this uncommon complication of hematopoietic cell transplantation (HCT). METHODS: Patients receiving a first allogeneic HCT between 2008-2013 as reported to the Center for International Blood & Marrow Transplant Research (N=13,097) were randomly divided into training and validation sets. Independent prognostic factors for development of VOD by day+100 post HCT were identified with a multivariate logistic regression model...
June 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29928948/single-dose-daily-fractionated-is-not-inferior-to-twice-a-day-fractionated-total-body-irradiation-prior-to-allogeneic-stem-cell-transplantation-for-acute-leukemia-a-useful-practice-simplification-resulting-from-the-sarasin-study
#5
Yazid Belkacemi, Myriam Labopin, Sebastian Giebel, Norbert Claude Gorin, Gokoulakrichenane Loganadane, Leszek Miszczyk, Mauricette Michallet, Gerard Socié, Nicolaas Pm Schaap, Jan J Cornelissen, Ibrahim Yakoub-Agha, Emmanuelle Polge, Mohamad Mohty, Arnon Nagler
PURPOSE: Total-body irradiation (TBI) is a major constituent of myeloablative conditioning regimens. The standard technique consists of 12Gy in 6 fractions over 3 days. The SARASIN study aimed to compare standard-fractionation to one-daily fractionation prior to transplant in leukemia. MATERIAL AND METHODS: We retrospectively compared TBI regimens delivered in 2993 patients from the EBMT database, transplanted between 2000 and 2014 for acute lymphoblastic (ALL, n=1729) or acute myelogenous (AML, n=1264) leukemia...
June 18, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29928900/characterization-and-comparison-of-human-limbal-explant-cultures-grown-under-defined-and-xeno-free-conditions
#6
Kristyna Brejchova, Peter Trosan, Pavel Studeny, Pavlina Skalicka, Tor Paaske Utheim, Jan Bednar, Katerina Jirsova
Human limbal epithelial cells (LECs) intended for treatment of limbal stem cell deficiency are commonly cultivated on a 3T3 feeder layer with complex culture medium supplemented with fetal bovine serum (FBS). However, FBS is a xenogeneic component containing poorly characterised constituents and exhibits quantitative and qualitative lot-to-lot variations. Human limbal explants were plated on untreated or fibrin coated plastic plates and cultured in two non-xenogeneic media (supplemented with either human serum or platelet lysate only)...
June 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#7
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29928768/high-altitude-trekking-after-lung-transplantation-a-prospective-study-using-lung-ultrasound-to-detect-comets-tails-for-interstital-pulmonary-edema-in-lung-transplant-recipients-and-healthy-volunteers
#8
Ulrike Weber, Judith Schiefer, Jakob Mühlbacher, Martin Hermann Bernardi, Clemens Maria Ortner, Peter Jaksch
The intensity of physical activity which can be tolerated after lung transplantation and the tolerance to prolonged exercise at high altitude are poorly investigated. Lung ultrasound comet tails have been used in the diagnosis of interstitial pulmonary edema and high pulmonary altitude edema. The aim was to asses the number of lung ultrasound comet tails and to monitor changes in the optic nerve sheath diameter (ONSD) during a climb to the top of Mount Kilimanjaro in 10 lung transplant recipients and 10 healthy controls at three different altitude levels: 1360m, 3505m, 4900m...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29928683/everolimus-and-papillomavirus-lesions-in-female-renal-transplant-recipient-a-case-report
#9
T Simundic, L Zibar, K Sego
We describe the case of a transplanted patient with high-risk HPV infection that manifested as multiple genital condylomas and abnormal Papanicolaou (Pap) smear. Her immunosuppressants were corticosteroids, cyclosporine, and azathioprine. Since gynecologic treatments to eradicate condylomas were completely unsuccessful, cyclosporine was replaced by everolimus. Soon after, condylomas disappeared, HPV status became negative, and Pap smear returned to normal and has remained normal since.
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29928656/long-term-phase-1-2-intraspinal-stem-cell-transplantation-outcomes-in-als
#10
Stephen A Goutman, Morton B Brown, Jonathan D Glass, Nicholas M Boulis, Karl Johe, Tom Hazel, Merit Cudkowicz, Nazem Atassi, Lawrence Borges, Parag G Patil, Stacey A Sakowski, Eva L Feldman
Objective: Intraspinal human spinal cord-derived neural stem cell (HSSC) transplantation is a potential therapy for amyotrophic lateral sclerosis (ALS); however, previous trials lack controls. This post hoc analysis compared ambulatory limb-onset ALS participants in Phase 1 and 2 (Ph1/2) open-label intraspinal HSSC transplantation studies up to 3 years after transplant to matched participants in Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) and ceftriaxone datasets to provide required analyses to inform future clinical trial designs...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928147/associations-between-physical-and-psychosocial-factors-and-health-related-quality-of-life-in-women-who-gave-birth-after-a-kidney-transplant
#11
Yuki Yoshikawa, Junji Uchida, Chiharu Akazawa, Nobuhiko Suganuma
Purpose: Health-related quality of life (HRQOL) among kidney transplant recipients is associated with physical and psychosocial characteristics. Furthermore, pregnancy and childcare may be particularly challenging for women. The aim of this study was to assess the relationship between patients' psychosocial characteristics and HRQOL, specifically for recipients who have given birth after their kidney transplant. Patients and methods: This was a cross-sectional study...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29928141/assessment-and-management-of-patients-with-intestinal-failure-a-multidisciplinary-approach
#12
REVIEW
Jennie T Grainger, Yasuko Maeda, Suzanne C Donnelly, Carolynne J Vaizey
Intestinal failure (IF) is a condition characterized by the inability to maintain a state of adequate nutrition, or fluid and electrolyte balance due to an anatomical or a physiological disorder of the gastrointestinal system. IF can be an extremely debilitating condition, significantly affecting the quality of life of those affected. The surgical management of patients with acute and chronic IF requires a specialist team who has the expertise in terms of technical challenges and decision-making. A dedicated IF unit will have the expertise in patient selection for surgery, investigative workup and planning, operative risk assessment with relevant anesthetic expertise, and a multidisciplinary team with support such as nutritional expertise and interventional radiology...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29928125/graft-outcomes-following-immunosuppressive-therapy-with-different-combinations-in-kidney-transplant-recipients-a-nationwide-cohort-study
#13
Yung-Fong Tsai, Fu-Chao Liu, Chang-Fu Kuo, Ting-Ting Chung, Huang-Ping Yu
Background: Immunosuppression plays an essential role to overcome immune-related allograft rejection, but it also causes some nephrotoxicity. This study aimed to investigate how the immunosuppressant combinations affect graft outcomes in kidney transplant recipients. Methods: A nationwide population-based cohort study using the Taiwan National Health Insurance Database was conducted. A total of 3,441 kidney transplant recipients who underwent kidney transplantation during the targeted period were included...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29928026/delayed-graft-function-is-associated-with-an-increased-rate-of-renal-allograft-rejection-a-retrospective-single-center-analysis
#14
Susanne Weber, Thomas Dienemann, Johannes Jacobi, Kai-Uwe Eckardt, Alexander Weidemann
INTRODUCTION: The association of delayed graft function (DGF) and biopsy proven acute rejection (BPAR) of renal allografts is controversial. Borderline rejections comprise a major portion of biopsy results but the significance of such histologic changes is debated. The present study explores the impact of DGF on BPAR with a special emphasis on discriminating the effects of borderline rejection. METHODS: Single center analysis of 417 deceased donor kidney recipients (age>18; transplantation date 1/2008-2/2015)...
2018: PloS One
https://www.readbyqxmd.com/read/29927838/-logistics-in-coordinating-the-first-adult-trans-atlantic-bilateral-hand-transplant-lessons-learned
#15
Oded Ben-Amotz, Erwin A Kruger, Christine McAndrew, David Bozentka, David Steinberg, Benjamin Chang, Laurent Lantieri, L Scott Levin
Hand transplantation requires precise preoperative planning and surgical execution. Coordinating a transplant team-including surgeons, anesthesiologists, nurses, and supporting staff-is a time-sensitive challenge when a donor-recipient match is confirmed. International human limb transplantation occurs when the recipient and donor are in separate countries. We describe the logistics behind the first trans-Atlantic adult bilateral hand transplantation, which, to date, required the highest level of coordination and timing...
June 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927830/living-donation-of-vascularized-composite-allografts
#16
Bohdan Pomahac, Muayyad Alhefzi, Ericka M Bueno, Sue V McDiarmid, L Scott Levin
Living donation has become a medically and ethically accepted practice in solid organ transplantation. Published proceedings from the international kidney transplant community and from the Ethics Committee of The Transplantation Society (TTS) articulated the general principles as well as specific recommendations for living donation, which remain the backbone of the Centers for Medicare and Medicaid Services (CMS) and Organ Procurement and Transplantation Network (OPTN) requirements and policies.Meanwhile, there have been major advancements in another revolutionary field of transplant medicine: vascularized composite allotransplantation, or VCA...
June 14, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29927763/nutrition-dietary-intake-and-eating-behavior-after-liver-transplantation
#17
Lucilene Rezende Anastácio, Samanta Catherine Ferreira
PURPOSE OF REVIEW: Nutritional status of patients after liver transplantation is affected by dietary intake and this, in turn, is affected by eating behavior. The present review will highlight recent studies on these topics after liver transplantation. RECENT FINDINGS: Malnutrition drops significantly after liver transplantation. Recovery of weight lost during liver disease occurs within 1 year. Liver transplantation recipients gain weight up to the second or third year, often becoming overweight and obese...
June 20, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29927618/sertoli-cells-engineered-to-express-insulin-to-lower-blood-glucose-in-diabetic-mice
#18
Gurvinder Kaur, Lea Ann Thompson, Rachel L Babcock, Karl Mueller, Jannette M Dufour
Long-term survival of allo- and xenotransplanted immune-privileged Sertoli cells (SCs) is well documented suggesting that SCs can be used to deliver foreign proteins for cell-based gene therapy. The aim of this study was to use a lentivirus carrying proinsulin cDNA to achieve stable expression and lowering of blood glucose levels (BGLs). A SC line transduced with the lentivirus (MSC-LV-mI) maintained stable insulin expression in vitro. These MSC-LV-mI cells were transplanted and grafts were analyzed for cell survival, continued proinsulin mRNA, and insulin protein expression...
June 21, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29927482/patient-selection-and-timing-of-allogeneic-hematopoietic-stem-cell-transplantation-for-relapsed-follicular-lymphoma
#19
Mike Fillon
No abstract text is available yet for this article.
June 21, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29927463/expenses-of-the-brazilian-public-healthcare-system-with-chronic-kidney-disease
#20
Paulo Roberto Alcalde, Gianna Mastroianni Kirsztajn
INTRODUCTION: The prevalence of chronic kidney disease (CKD) is increasing worldwide, with costs that can be impeditive. OBJECTIVE: To establish the expenses of the Brazilian Public Healthcare System (SUS), with hospitalizations due to CKD and related diseases; evaluating expenses with renal replacement therapy (RRT). METHODS: We have assessed the values paid by the SUS in the triennium 2013-2015, for estimating annual expenses with CKD treatment and hospitalization, associated diseases, and exams...
June 4, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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