Luciana Daniela Garlisi Torales, Benjamin A Sempowski, Georgia L Krikorian, Kristina M Woodis, Scott M Paulissen, Christopher L Smith, Sarah E Sheppard
Central conducting lymphatic anomaly (CCLA) is a complex lymphatic anomaly characterized by abnormalities of the central lymphatics and may present with nonimmune fetal hydrops, chylothorax, chylous ascites, or lymphedema. CCLA has historically been difficult to diagnose and treat; however, recent advances in imaging, such as dynamic contrast magnetic resonance lymphangiography, and in genomics, such as deep sequencing and utilization of cell-free DNA, have improved diagnosis and refined both genotype and phenotype...
April 15, 2024: Journal of Clinical Investigation