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Colistina

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https://www.readbyqxmd.com/read/29506194/influence-of-diluent-volume-of-colistimethate-sodium-on-aerosol-characteristics-and-pharmacokinetics-in-ventilator-associated-pneumonia-caused-by-mdr-bacteria
#1
Kevin Bihan, Noël Zahr, Marie-Hélène Becquemin, Xiao Lu, Jean-François Bertholon, Corinne Vezinet, Charlotte Arbelot, Antoine Monsel, Jean-Jacques Rouby, Olivier Langeron, Qin Lu
Objectives: Nebulized colistimethate sodium (CMS) can be used to treat ventilator-associated pneumonia caused by MDR bacteria. The influence of the diluent volume of CMS on aerosol delivery has never been studied. The main objectives of the study were to compare aerosol particle characteristics and plasma and urine pharmacokinetics between two diluent volumes in patients treated with nebulized CMS. Methods: A crossover study was conducted in eight patients receiving nebulized CMS every 8 h...
February 28, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27684296/determination-of-colistin-and-colistimethate-levels-in-human-plasma-and-urine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#2
Kevin Bihan, Qin Lu, Manon Enjalbert, Maxime Apparuit, Olivier Langeron, Jean-Jacques Rouby, Christian Funck-Brentano, Noël Zahr
BACKGROUND: Colistin is a polypeptide antibiotic from the polymyxin E group used for the treatment of infections caused by multidrug-resistant gram-negative bacteria. The main constituents, accounting for approximately 85% of this mixture, are colistin A (polymyxin E1) and colistin B (polymyxin E2). The aim of this study was to develop and validate new and fast methods of quantification of colistin A and B and its precursors [colistin methanesulfonate sodium (CMS) A and B] by ultraperformance liquid chromatography-tandem mass spectrometry in plasma and urine with short pretreatment and run times...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/24125007/-emergence-of-colistin-resistant-klebsiella-pneumoniae-microbiological-and-epidemiological-characterization-of-the-isolates-producing-and-non-producing-kpc-type-carbapenemase
#3
Marcela Nastro, Néstor Carranza, Fernando Aprigliano, Elsa Saposnik, Claudia Barberis, Susana García, Carlos Vay, Carlos H Rodríguez, Angela Famiglietti
Se estudiaron 64 aislamientos de K. pneumoniae resistentes a colistina recuperados de materiales clínicos de 57 pacientes atendidos entre los años 2010 y 2012 en el Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, con el objetivo de describir las características microbiológicas y epidemiológicas y los factores relacionados con la emergencia de estos aislamientos. Se incluyeron en el estudio 54 aislamientos de K. pneumoniae sensibles a colistina contemporáneos a los aislamientos resistentes...
July 2013: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/10079538/-clinical-manifestations-of-stenotrophomas-xanthomonas-maltophilia-infection
#4
R Julve, E Rovira, A Belda, J Prat, R Escoms, A Albert, F Gonzalvo
OBJECTIVE: Stenotrophomonas maltophilia (SM) is a gram-negative bacillus whose incidence like nosocomial pathogen has been incremented in the last years, especially in immunocompromised patients, subjected to invasive procedures and those receiving broad-spectrum antimicrobial therapy. METHOD: We report 15 isolations of SM between 1994-1996. RESULTS: The criteria for SM infection were fulfilled by 9 patients (60%), and 6 patients (40%) were colonized...
September 1998: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
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