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https://www.readbyqxmd.com/read/28209604/birth-size-risk-factors-across-life-and-cognition-in-late-life-protocol-of-prospective-longitudinal-follow-up-of-the-mynah-mysore-studies-of-natal-effects-on-ageing-and-health-cohort
#1
Murali Krishna, G Mohan Kumar, S R Veena, G V Krishnaveni, Kalyanaraman Kumaran, Samuel Christaprasad Karat, Patsy Coakley, Clive Osmond, John R M Copeland, Giriraj Chandak, Dattatray Bhat, Mathew Varghese, Martin Prince, Caroline Fall
INTRODUCTION: For late-life neurocognitive disorders, as for other late-life chronic diseases, much recent interest has focused on the possible relevance of Developmental Origins of Health and Disease (DOHaD). Programming by undernutrition in utero, followed by overnutrition in adult life may lead to an increased risk, possibly mediated through cardiovascular and metabolic pathways. This study will specifically examine, if lower birth weight is associated with poorer cognitive functioning in late life in a south Indian population...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28201873/insights-into-the-formation-and-structures-of-starch-protein-lipid-complexes
#2
Shujun Wang, Mengge Zheng, Jinglin Yu, Shuo Wang, Les Copeland
The aim of the present study was to characterize the multi-scale structures of ternary complexes of a model system of starch, fatty acid (FA) and β-lactoglobulin (βLG) prepared using a Rapid Visco Analyser (RVA). The addition of βLG to starch-lauric acid or starch-oleic acid RVA pastes resulted in the increased intensity or occurrence of a new viscosity peak during cooling when the RVA protocol was repeated. The viscosity peak was attributed to the formation of starch-βLG-FA complexes. Differential scanning calorimetry (DSC) results showed clearly that starch-βLG-FAs complex was formed as gelatinized starch was cooled in the presence of βLG and FAs...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28198983/prolonged-sedentary-time-and-physical-fitness-among-canadian-men-and-women-aged-60-to-69
#3
Shilpa Dogra, Janine M Clarke, Jennifer L Copeland
BACKGROUND: Evidence for associations between prolonged sedentary time and breaks in sedentary time and fitness is limited in older adults. This study examines associations between objectively measured and self-reported total sedentary time and breaks in sedentary time with cardiorespiratory and musculoskeletal fitness among Canadian men and women aged 60 to 69. DATA AND METHODS: Data from cycles 1 and 2 of the Canadian Health Measures Survey were used for analysis...
February 15, 2017: Health Reports
https://www.readbyqxmd.com/read/28197806/recruiting-families-at-risk-for-hereditary-breast-and-ovarian-cancer-from-a-statewide-cancer-registry-a-methodological-study
#4
Maria C Katapodi, Deb Duquette, James J Yang, Kari Mendelsohn-Victor, Beth Anderson, Christos Nikolaidis, Emily Mancewicz, Laurel L Northouse, Sonia Duffy, David Ronis, Kara J Milliron, Nicole Probst-Herbst, Sofia D Merajver, Nancy K Janz, Glenn Copeland, Scott Roberts
PURPOSE: Cancer genetic services (counseling/testing) are recommended for women diagnosed with breast cancer younger than 45 years old (young breast cancer survivors-YBCS) and at-risk relatives. We present recruitment of YBCS, identification and recruitment of at-risk relatives, and YBCS willingness to contact their cancer-free, female relatives. METHODS: A random sample of 3,000 YBCS, stratified by race (Black vs. White/Other), was identified through a population-based cancer registry and recruited in a randomized trial designed to increase use of cancer genetic services...
February 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28196272/deep-sequencing-of-71-candidate-genes-to-characterize-variation-associated-with-alcohol-dependence
#5
Shaunna L Clark, Daniel E Adkins, Gaurav Kumar, Karolina A Aberg, Sri Nerella, Linying Xie, Ann L Collins, James J Crowley, Corey R Quackenbush, Christopher E Hilliard, Andrey A Shabalin, Scott I Vrieze, Roseann E Peterson, William E Copeland, Judy L Silberg, Matt McGue, Hermine Maes, William G Iacono, Patrick F Sullivan, Elizabeth J Costello, Edwin J van den Oord
BACKGROUND: Previous genome-wide association studies (GWASs) have identified a number of putative risk loci for alcohol dependence (AD). However, only a few loci have replicated and these replicated variants only explain a small proportion of AD risk. Using an innovative approach, the goal of this study was to generate hypotheses about potentially causal variants for AD that can be explored further through functional studies. METHODS: We employed targeted capture of 71 candidate loci and flanking regions followed by next-generation deep sequencing (mean coverage 78X) in 806 European Americans...
February 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28185147/incompatible-with-care-examining-trisomy-18-medical-discourse-and-families-counter-discourse-for-recuperative-ethos
#6
Megan J Thorvilson, Adam J Copeland
Parents whose child is diagnosed with a serious disease such as trisomy 18 first rely on the medical community for an accurate description and prognosis. In the case of trisomy 18, however, many families are told the disease is "incompatible with life" even though some children with the condition live for several years. This paper considers parents' response to current medical discourse concerning trisomy 18 by examining blogs written by the parents of those diagnosed. Using interpretive humanistic reading and foregrounding Cathryn Molloy's recuperative ethos theory (2015), we find that parents demonstrate recuperative ethos in response to physicians' descriptions of trisomy 18, particularly in rhetoric addressing survival, medicalized language, and religious and/or spiritual rhetoric...
February 10, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28169574/fitness-equipment-in-public-parks-frequency-of-use-and-community-perceptions-in-a-small-urban-centre
#7
Jennifer L Copeland, Cheryl Currie, Ali Walker, Erin Mason, Taura Willoughby, Ashley Amson
BACKGROUND: Providing freely accessible exercise facilities may increase physical activity at a population level. An increasingly popular strategy is outdoor fitness equipment in urban parks. Few studies have evaluated the effectiveness of this intervention in smaller cities. This study examined fitness equipment use, perceived effectiveness, and ways to increase use in a city of 95,000 people in 2015. METHODS: Two parks with fitness equipment and 4 without were directly observed...
February 7, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28167247/results-and-limitations-of-humeral-head-resurfacing-105-cases-at-a-mean-follow-up-of-5-years
#8
K Soudy, C Szymanski, C Lalanne, C Bourgault, A Thiounn, A Cotten, C Maynou
BACKGROUND: The objective of this study was to assess clinical and computed-tomography (CT) outcomes at least 2 years after humeral head resurfacing to treat concentric gleno-humeral osteoarthritis. HYPOTHESIS: Humeral head resurfacing provides similar outcomes to those achieved with stemmed humeral head implants. MATERIALS AND METHODS: This single-centre retrospective studyincluded 40 Copeland™ and 65 Aequalis™ humeral resurfacing heads implanted between 2004 and 2012...
February 3, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28162849/comparison-of-brief-versus-extended-personalised-feedback-in-an-online-intervention-for-cannabis-users-short-term-findings-of-a-randomised-trial
#9
Jan Copeland, Sally Rooke, Dan Rodriquez, Melissa M Norberg, Lisa Gibson
: Previous studies have shown brief online self-help interventions to be a useful method of treating cannabis use and related problems; however, no studies have compared the effects of brief versus extended feedback for online brief intervention programs. OBJECTIVES: The current study was a two arm randomised trial aimed at testing the short term effectiveness of a brief and extended feedback version of Grassessment, a brief online intervention for cannabis users that provides individualised feedback regarding use, motives, and harms...
February 2, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28161950/structural-orders-of-wheat-starch-do-not-determine-the-in-vitro-enzymatic-digestibility
#10
Shujun Wang, Shaokang Wang, Lu Liu, Shuo Wang, Les Copeland
In this study, we elucidated the underlying mechanisms that are responsible for the rate-limiting step for wheat starch digestion. Wheat starch samples with a degree of gelatinization (DG) ranging from 0 to 100% were prepared. As DG increased, the ordered structures of the starch were disrupted increasingly. In contrast, almost all of the increase in the rate and extent of in vitro enzymatic digestion coincided with a DG of only 6% and a minor loss of structural order. As DG increased beyond 6%, digestibility of the starch increased only slightly...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28159845/prevalence-and-determinants-of-undetected-dementia-in-the-community-a-systematic-literature-review-and-a-meta-analysis
#11
Linda Lang, Angela Clifford, Li Wei, Dongmei Zhang, Daryl Leung, Glenda Augustine, Isaac M Danat, Weiju Zhou, John R Copeland, Kaarin J Anstey, Ruoling Chen
OBJECTIVES: Detection of dementia is essential for improving the lives of patients but the extent of underdetection worldwide and its causes are not known. This study aimed to quantify the prevalence of undetected dementia and to examine its correlates. METHODS/SETTING/PARTICIPANTS: A systematic search was conducted until October 2016 for studies reporting the proportion of undetected dementia and/or its determinants in either the community or in residential care settings worldwide...
February 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28158711/developing-virtual-public-health-networks-aspiration-and-reality
#12
Amelia A Lake, Jon Warren, Alison Copeland, Rosemary Rushmer, Clare Bambra
No abstract text is available yet for this article.
December 2, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/28154977/sex-differences-in-the-response-of-total-pyy-and-glp-1-to-moderate-intensity-continuous-and-sprint-interval-cycling-exercise
#13
Tom J Hazell, Logan K Townsend, Jillian R Hallworth, Jon Doan, Jennifer L Copeland
BACKGROUND: Exercise interventions are often less effective at improving body composition for females than males, potentially due to post-exercise hormonal responses that increase energy intake in females. Recently, sprint interval training was shown to effectively reduce body fat in females despite being relatively low during exercise energy expenditure. PURPOSE: To determine whether any sex difference in total PYY, GLP-1 or perceived hunger exists following moderate-intensity continuous exercise (MICT) and sprint interval exercise (SIT) METHODS: Twenty-one active participants (11 females) participated in three sessions in a randomized crossover design: (1) MICT, 30-min cycling at 65% VO2max; (2) SIT, 6 × 30 s "all-out" sprints with 4-min recovery periods; (3) control (CTRL; no exercise)...
February 2, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28154168/synergistic-effects-of-the-in-cis-t251i-and-p587l-mitochondrial-dna-polymerase-%C3%AE-disease-mutations
#14
Karen L DeBalsi, Matthew J Longley, Kirsten E Hoff, William C Copeland
Human mitochondrial DNA (mtDNA) polymerase gamma (Pol γ) is the only polymerase known to replicate the mitochondrial genome. The Pol γ holoenzyme consists of the p140 catalytic subunit (POLG) and the p55 homodimeric accessory subunit (POLG2), which enhances binding of Pol γ to DNA and promotes processivity of the holoenzyme. Mutations within POLG impede maintenance of mtDNA and cause mitochondrial diseases. Two common POLG mutations usually found in cis in patients primarily with progressive external ophthalmoplegia (PEO) generate T251I and P587L amino acid substitutions...
February 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28146334/dementia-and-co-occurring-chronic-conditions-a-systematic-literature-review-to-identify-what-is-known-and-where-are-the-gaps-in-the-evidence
#15
REVIEW
Mark B Snowden, Lesley E Steinman, Lucinda L Bryant, Monique M Cherrier, Kurt J Greenlund, Katherine H Leith, Cari Levy, Rebecca G Logsdon, Catherine Copeland, Mia Vogel, Lynda A Anderson, David C Atkins, Janice F Bell, Annette L Fitzpatrick
OBJECTIVE: The challenges posed by people living with multiple chronic conditions are unique for people with dementia and other significant cognitive impairment. There have been recent calls to action to review the existing literature on co-occurring chronic conditions and dementia in order to better understand the effect of cognitive impairment on disease management, mobility, and mortality. METHODS: This systematic literature review searched PubMed databases through 2011 (updated in 2016) using key constructs of older adults, moderate-to-severe cognitive impairment (both diagnosed and undiagnosed dementia), and chronic conditions...
February 1, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28138826/association-between-maternal-stress-work-status-concern-about-child-weight-and-restrictive-feeding-practices-in-preschool-children
#16
Katheryn Swyden, Susan B Sisson, Amanda S Morris, Karina Lora, Ashley E Weedn, Kristen A Copeland, Beth DeGrace
Objectives To examine the relationship between maternal stress, work status, concern about child weight, and the use of restrictive feeding practices among mothers of preschool children. Methods 285 mothers of 2-to-5-year-old children completed an on-line survey. Questions included demographics, items from the Depression Anxiety Stress Scale, and the Child Feeding Questionnaire. Linear regression and ANOVA examined the relationship between maternal stress, work hours, concern about child weight, and the use of restrictive practices for one 2-to-5-year-old child living within the home...
January 30, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28117058/cannabis-use-and-disorder-from-childhood-to-adulthood-in-a-longitudinal-community-sample-with-american-indians
#17
William E Copeland, Sherika Hill, E Jane Costello, Lilly Shanahan
OBJECTIVE: Recent changes in DSM criteria require new documentation of the prevalence and developmental sequences of cannabis use disorder (CUD). The goal of this study was to investigate the early course of DSM-5 CUD and its overlap with DSM-IV and consumption constructs in a community-representative sample of American Indians. METHOD: Data came from the prospective, longitudinal, population-based Great Smoky Mountains Study in North Carolina (N = 1,420, including 349 American Indians)...
February 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28114395/assisted-reproductive-technology-and-newborn-size-in-singletons-resulting-from-fresh-and-cryopreserved-embryos-transfer
#18
Galit Levi Dunietz, Claudia Holzman, Yujia Zhang, Nicole M Talge, Chenxi Li, David Todem, Sheree L Boulet, Patricia McKane, Dmitry M Kissin, Glenn Copeland, Dana Bernson, Michael P Diamond
OBJECTIVES AND STUDY DESIGN: The aim of this study was two-fold: to investigate the association of Assisted Reproductive Technology (ART) and small newborn size, using standardized measures; and to examine within strata of fresh and cryopreserved embryos transfer, whether this association is influenced by parental infertility diagnoses. We used a population-based retrospective cohort from Michigan (2000-2009), Florida and Massachusetts (2000-2010). Our sample included 28,946 ART singletons conceived with non-donor oocytes and 4,263,846 non-ART singletons...
2017: PloS One
https://www.readbyqxmd.com/read/28105717/beyond-food-the-multiple-pathways-for-inclusion-of-materials-into-ancient-dental-calculus
#19
Anita Radini, Efthymia Nikita, Stephen Buckley, Les Copeland, Karen Hardy
Dental calculus (mineralized dental plaque) was first recognised as a potentially useful archaeological deposit in the 1970s, though interest in human dental calculus as a resource material has increased sharply in the past few years. The majority of recent research has focused on the retrieval of plant microfossils embedded in its matrix and interpretation of these finds as largely the result of deliberate consumption of plant-derived food. However, while most of the material described in published works does represent food, dental calculus is in fact a "depositional environment" as material can enter the mouth from a range of sources...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28099038/an-exome-sequencing-study-to-assess-the-role-of-rare-genetic-variation-in-pulmonary-fibrosis
#20
Slavé Petrovski, Jamie L Todd, Michael T Durheim, Quanli Wang, Jason W Chien, Fran L Kelly, Courtney Frankel, Caroline M Mebane, Zhong Ren, Joshua Bridgers, Thomas J Urban, Colin D Malone, Ashley Finlen Copeland, Christie Brinkley, Andrew S Allen, Thomas O'Riordan, John G McHutchison, Scott M Palmer, David B Goldstein
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is an increasingly recognized, often fatal lung disease of unknown etiology. OBJECTIVES: The aim of this study was to use whole-exome sequencing to improve our understanding of the genetic architecture of pulmonary fibrosis. METHODS: We performed a case-control exome-wide collapsing analysis including 262 unrelated individuals with pulmonary fibrosis; clinically classified as IPF according to ATS/ERS/JRS/ALAT guidelines (81...
January 18, 2017: American Journal of Respiratory and Critical Care Medicine
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