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https://www.readbyqxmd.com/read/28433350/open-repair-of-chronic-thoracic-and-thoracoabdominal-aortic-dissection-using-deep-hypothermia-and-circulatory-arrest
#1
Joel Corvera, Hannah Copeland, David Blitzer, Adam Hicks, Joshua Manghelli, Philip Hess, John Fehrenbacher
BACKGROUND: Chronic dissection of the thoracic and thoracoabdominal aorta as sequela of a prior type A or B dissection is a challenging problem that requires close radiographic surveillance and prompt operative intervention in the presence of symptoms or aneurysm formation. Open repair of chronic thoracic and thoracoabdominal aortic dissection using deep hypothermia has been our preferred method to treat this complex pathology. The advantages of this technique include organ and spinal cord protection, the flexibility to extend the repair proximally into the arch, and the ability to limit ischemia to all vascular beds...
March 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28428443/mechanisms-of-pinometostat-epz-5676-treatment-emergent-resistance-in-mll-rearranged-leukemia
#2
Carly T Campbell, Jessica N Haladyna, David A Drubin, Ty M Thomson, Michael J Maria, Taylor Yamauchi, Nigel J Waters, Edward J Olhava, Roy M Pollock, Jesse J Smith, Robert A Copeland, Stephen J Blakemore, Kathrin M Bernt, Scott R Daigle
DOT1L is a protein methyltransferase involved in the development and maintenance of MLL-rearranged (MLL-r) leukemia through its ectopic methylation of histones associated with well characterized leukemic genes.  Pinometostat (EPZ-5676), a selective inhibitor of DOT1L, is in clinical development in relapsed/refractory acute leukemia patients harboring rearrangements of the MLL gene. The observation of responses and subsequent relapses in the adult trial treating MLL-r patients motivated preclinical investigations into potential mechanisms of pinometostat treatment emergent resistance (TER) in cell lines confirmed to have MLL-r...
April 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28427303/values-based-practice-a-framework-for-thinking-with
#3
Kay Mohanna
Values are those principles that govern behaviours, and values-based practice has been described as a theory and skills base for effective healthcare decision-making where different (and hence potentially conflicting) values are in play. The emphasis is on good process rather than pre-set right outcomes, aiming to achieve balanced decision-making. In this article we will consider the utility of this model by looking at leadership development, a current area of much interest and investment in healthcare. Copeland points out that 'values based leadership behaviors are styles with a moral, authentic and ethical dimension', important qualities in healthcare decision-making...
April 21, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28416443/astrocytes-modulate-thalamic-sensory-processing-via-mglu2-receptor-activation
#4
C S Copeland, T M Wall, R E Sims, S A Neale, E Nisenbaum, H R Parri, T E Salt
Astrocytes possess many of the same signalling molecules as neurons. However, the role of astrocytes in information processing, if any, is unknown. Using electrophysiological and imaging methods, we report the first evidence that astrocytes modulate neuronal sensory inhibition in the rodent thalamus. We found that mGlu2 receptor activity reduces inhibitory transmission from the thalamic reticular nucleus to the somatosensory ventrobasal thalamus (VB): mIPSC frequencies in VB slices were reduced by the Group II mGlu receptor agonist LY354740, an effect potentiated by mGlu2 positive allosteric modulator (PAM) LY487379 co-application (30 nM LY354740: 10...
April 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28412344/insights-into-structure-and-function-of-high-pressure-modified-starches-with-different-crystalline-polymorphs
#5
Jinrong Wang, Huaping Zhu, Sha Li, Shujun Wang, Shuo Wang, Les Copeland
The effect of high pressure (HP) treatment at 200-600MPa for 30min on properties of three starches with different polymorphs was investigated. HP treatment altered greatly the morphology of wheat starch, especially at 400MPa or higher. The crystallinity of wheat starch decreased from 22.6% for native starch to 3.4% for starch after treatment at 600MPa. The short-range molecular order as measured by FTIR and Raman spectroscopy decreased with increasing treatment pressure. HP treatment had little effect on structural properties of potato and yam starches, except for yam starch after treatment at 600MPa...
April 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28411561/selective-attention-moderates-the-relationship-between-attentional-capture-by-signals-of-nondrug-reward-and-illicit-drug-use
#6
Lucy Albertella, Jan Copeland, Daniel Pearson, Poppy Watson, Reinout W Wiers, Mike E Le Pelley
BACKGROUND: The current study examined whether cognitive control moderates the association between (non-drug) reward-modulated attentional capture and use of alcohol and other drugs (AOD). METHODS: Participants were 66 university students who completed an assessment including questions about AOD use, a visual search task to measure value-modulated attentional capture, and a goal-directed selective attention task as a measure of cognitive control. RESULTS: The association between the effect of value-modulated attentional capture and illicit drug use was moderated by level of cognitive control...
March 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28402660/reply-to-comment-on-terrestrial-scavenging-of-marine-mammals-cross-ecosystem-contaminant-transfer-and-potential-risks-to-endangered-california-condors-gymnogyps-californianus
#7
Myra E Finkelstein, Victoria J Bakker, Holly Copeland, Joe Burnett, Jennie Jones Scherbinski, Joseph Brandt, Carolyn M Kurle
No abstract text is available yet for this article.
April 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28398800/rethinking-the-black-panther-party-can-help-us-rethink-our-strategies-in-public-health
#8
Carmen Dickinson-Copeland, Samantha Bent Weber
No abstract text is available yet for this article.
May 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28390434/surgical-site-infections-following-oral-cavity-cancer-resection-and-reconstruction-is-a-risk-factor-for-plate-exposure
#9
Christopher M Yao, Hedyeh Ziai, Gordon Tsang, Andrea Copeland, Dale Brown, Jonathan C Irish, Ralph W Gilbert, David P Goldstein, Patrick J Gullane, John R de Almeida
BACKGROUND: Plate-related complications following head and neck cancer ablation and reconstruction remains a challenging problem often requiring further management and reconstructive surgeries. We aim to identify an association between surgical site infections (SSI) and plate exposure. METHODS: A retrospective study between 1997 and 2014 was performed to study the association between postoperative SSI and plate exposures. Eligible patients included those with a history of oral squamous cell carcinoma who underwent surgical resection, neck dissection, and free tissue reconstruction...
April 8, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28381369/reliability-of-video-recordings-to-evaluate-quality-of-anesthesia-recovery-in-dogs
#10
Jennifer E Copeland, Erik H Hofmeister, Benjamin M Brainard, Jane E Quandt
OBJECTIVE: To assess the reliability of using video recordings to evaluate anesthesia recovery in dogs. STUDY DESIGN: Prospective study. ANIMALS: A total of 30 dogs undergoing surgery. METHODS: Recovery monitoring and video recording lasted from extubation until 1 hour later. Scoring was done in real time at the end of the hour by a graduate student using three systems: a simple descriptive scale, visual analog scale and numeric rating scale...
January 12, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28378429/impact-of-lifestyle-behavior-change-on-glycemic-control-in-youth-with-type-2-diabetes
#11
Andrea Kriska, Laure El Ghormli, Kenneth C Copeland, Janine Higgins, Carolyn E Ievers-Landis, Lorraine E Levitt Katz, Paula M Trief, Aimee D Wauters, Patrice M Yasuda, Linda M Delahanty
BACKGROUND: Little is known about the feasibility and impact of lifestyle intervention, determined by change in diet and cardiovascular fitness (CRF), on glycemic control in youth who are overweight with type 2 diabetes. This was examined in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial cohort from across 15 US centers. SUBJECTS: TODAY enrolled 699 youth aged 10 to 17 years with type 2 diabetes <2 years and body mass index ≥85th percentile at baseline...
April 4, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28377413/quantifying-the-release-of-biomarkers-of-myocardial-necrosis-from-cardiac-myocytes-and-intact-myocardium
#12
Jack Marjot, Thomas E Kaier, Eva D Martin, Shiney S Reji, O'Neal Copeland, Mohammed Iqbal, Bob Goodson, Sarah Hamren, Sian E Harding, Michael S Marber
BACKGROUND: Myocardial infarction is diagnosed when biomarkers of cardiac necrosis exceed the 99th centile, although guidelines advocate even lower concentrations for early rule-out. We examined how many myocytes and how much myocardium these concentrations represent. We also examined if dietary troponin can confound the rule-out algorithm. METHODS: Individual rat cardiac myocytes, rat myocardium, ovine myocardium, or human myocardium were spiked into 400-μ L aliquots of human serum...
April 4, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28359617/fluid-attenuated-inversion-recovery-flair-signal-intensity-can-identify-stroke-within-6-and-8-hours
#13
John Legge, Ada Graham, Shailesh Male, David Copeland, Richard Lee, Nitin Goyal, Ramin Zand
BACKGROUND: Patients with wake-up or unknown time of onset stroke are usually excluded from recanalization. However, a few studies indicate that some magnetic resonance sequences can help predict time from symptom onset (SxO). Our goal was to assess the value of fluid-attenuated inversion recovery (FLAIR) signal intensity ratio (SIR) in identifying patients within 6 and 8 hours of stroke onset. MATERIALS AND METHODS: We studied consecutive acute stroke patients with known time of onset who underwent magnetic resonance imaging (MRI) within 48 hours of SxO...
March 27, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28355616/medical-evacuations-in-the-oil-and-gas-industry-a-retrospective-review-with-implications-for-future-evacuation-and-preventative-strategies%C3%A2
#14
Sharyn Toner, Derkje H Andrée Wiltens, Johannes Berg, Hector Williams, Susan Klein, Simon Marshall, Neil Nerwich, Ryan Copeland
BACKGROUND: Businesses increasingly conduct operations in remote areas where medical evacuation [Medevac(s)] carries more risk. Royal Dutch Shell developed a remote healthcare strategy whereby enhanced remote healthcare is made available to the patient through use of telemedicine and telemetry. To evaluate that strategy, a review of Medevacs of Shell International employees [i.e. expatriate employees (EEs) and frequent business travellers (FBTs)] was undertaken. METHOD: A retrospective review of Medevac data (period 2008-12) that were similar in operational constraints and population profile was conducted...
May 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28292935/selective-killing-of-smarca2-and-smarca4-deficient-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-cells-by-inhibition-of-ezh2-in-vitro-and-in-vivo-preclinical-models
#15
Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R Grassian, Igor Feldman, Sarah K Knutson, Kristy Kuplast-Barr, Maria Roche, John Campbell, Peter Ho, Robert A Copeland, Richard Chesworth, Jesse J Smith, Heike Keilhack, Scott A Ribich
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that in preclinical models, malignant rhabdoid tumors, which are deficient in the SWI/SNF core component INI1 (SMARCB1), are selectively killed by inhibitors of the H3K27 histone methyltransferase EZH2. Given the demonstrated antagonistic activities of the SWI/SNF complex and the EZH2-containing PRC2 complex, we investigated whether additional cancers with SWI/SNF mutations are sensitive to selective EZH2 inhibition...
March 14, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28289312/core-entrustable-professional-activities-for-new-pharmacy-graduates
#16
Stuart T Haines, Amy L Pittenger, Scott K Stolte, Cecilia M Plaza, Brenda L Gleason, Alexander Kantorovich, Marianne McCollum, Jennifer M Trujillo, Debra A Copeland, Matthew M Lacroix, Quamrun N Masuda, Peter Mbi, Melissa S Medina, Susan M Miller
No abstract text is available yet for this article.
February 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28288681/a-study-to-reduce-readmissions-after-surgery-in-the-veterans-health-administration-design-and-methodology
#17
Laurel A Copeland, Laura A Graham, Joshua S Richman, Amy K Rosen, Hillary J Mull, Edith A Burns, Jeff Whittle, Kamal M F Itani, Mary T Hawn
BACKGROUND: Hospital readmissions are associated with higher resource utilization and worse patient outcomes. Causes of unplanned readmission to the hospital are multiple with some being better targets for intervention than others. To understand risk factors for surgical readmission and their incremental contribution to current Veterans Health Administration (VA) surgical quality assessment, the study, Improving Surgical Quality: Readmission (ISQ-R), is being conducted to develop a readmission risk prediction tool, explore predisposing and enabling factors, and identify and rank reasons for readmission in terms of salience and mutability...
March 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28286674/the-effect-of-exercise-intensity-on-total-pyy-and-glp-1-in-healthy-females-a-pilot-study
#18
Jillian R Hallworth, Jennifer L Copeland, Jon Doan, Tom J Hazell
We compared the acute response of anorexigenic signals (total PYY and GLP-1) in response to submaximal and supramaximal exercise. Nine females completed three sessions: (1) moderate-intensity continuous training (MICT; 30 min; 65%  VO2max); (2) sprint interval training (SIT; 6 × 30 sec "all-out" cycling sprints with 4 min recovery); or (3) control (CTRL; no exercise). PYY and GLP-1 were measured via blood samples drawn before, immediately after, and 90 min after exercise. Perceptions of hunger were rated using a visual analogue scale at all blood sampling time points...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28272178/workplace-violence-and-perceptions-of-safety-among-emergency-department-staff-members-experiences-expectations-tolerance-reporting-and-recommendations
#19
Darcy Copeland, Melissa Henry
Workplace violence (WPV) is a widely recognized problem in emergency departments (EDs). The majority of WPV studies do not include nonclinical staff and do not address expectations of violence, tolerance to violence, or perceptions of safety. Among a multidisciplinary sample of ED staff members, specific study aims were to (a) describe exposure to WPV; (b) describe perceptions of safety, tolerance to violence, and expectation of violence; (c) describe reporting behaviors and perceived barriers to reporting violence; (d) examine relationships between demographic variables, experiences of violence, tolerance to violence, perceptions of safety, and reporting behaviors; and (e) identify perceptions of viable interventions to improve workplace safety...
March 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28271432/pharmacotherapy-for-weight-management-in-the-vha
#20
Todd P Semla, Chris Ruser, Chester B Good, Susan Z Yanovski, Donna Ames, Laurel A Copeland, Charles Billington, U Inge Ferguson, Louis J Aronne, Thomas A Wadden, W Timothy Garvey, Caroline M Apovian, David Atkins
Weight management medications (WMM) are underutilized as an adjunct to behavioral and lifestyle interventions. In fiscal years 2014-2015, a total of approximately 2500 veterans-a mere 2% of veterans receiving care from the Veterans Health Administration (VHA)-eligible for a WMM received a prescription for one. A State of the Art Conference on Weight Management workgroup, focused on pharmacotherapy, developed evidence-based recommendations and strategies to foster the appropriate use of WMM in the VHA. The workgroup identified patient, prescriber, and health system barriers to and facilitators for prescribing WMM...
April 2017: Journal of General Internal Medicine
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