keyword
MENU ▼
Read by QxMD icon Read
search

copeland

keyword
https://www.readbyqxmd.com/read/28940537/spending-per-medicare-beneficiary-is-higher-in-hospital-owned-small-and-medium-sized-physician-practices
#1
Michael F Pesko, Andrew M Ryan, Stephen M Shortell, Kennon R Copeland, Patricia P Ramsay, Xuming Sun, Jayme L Mendelsohn, Diane R Rittenhouse, Lawrence P Casalino
OBJECTIVE: To examine the relationship of physician versus hospital ownership of small- and medium-sized practices with spending and utilization of care. DATA SOURCE/STUDY SETTING/DATA COLLECTION: Survey data for 1,045 primary care-based practices of 1-19 physicians linked to Medicare claims data for 2008 for 282,372 beneficiaries attributed to the 3,010 physicians in these practices. STUDY DESIGN: We used generalized linear models to estimate the associations between practice characteristics and outcomes (emergency department visits, index admissions, readmissions, and spending)...
September 21, 2017: Health Services Research
https://www.readbyqxmd.com/read/28938089/drug-discovery-and-chemical-biology-of-cancer-epigenetics
#2
REVIEW
Scott Ribich, Darren Harvey, Robert A Copeland
Comprehensive whole-exome sequencing, DNA copy-number determination, and transcriptomic analyses of diverse cancers have greatly expanded our understanding of the biology of many tumor types. In addition to mutations in the common cell-of-origin specific driver mutations, these studies have also revealed a large number of loss-of-function and gain-of-function mutations in chromatin-modifying proteins (CMPs). This has revealed that epigenetic dysregulation is a common feature of most pediatric and adult cancers...
September 21, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28919000/intraobserver-and-interobserver-reliability-of-the-copeland-levy-classification-for-arthroscopic-evaluation-of-subacromial-impingement
#3
Ehud Atoun, Ron Gilat, Alexander van Tongel, Riten Pradhan, Ornit Cohen, Ehud Rath, Ofer Levy
BACKGROUND: Defining a simple and reliable classification for acromial and bursal impingement lesions is necessary to standardize terminology, to improve communication, and to allow better evaluation of the proper treatment of impingement lesions and rotator cuff tears. The purpose of this study was to assess orthopedic surgeons' intraobserver and interobserver reliability of the Copeland-Levy classification. METHODS: Six fellowship-trained orthopedic surgeons reviewed shoulder arthroscopy videos of 69 consecutive patients who underwent shoulder arthroscopy for rotator cuff tear repair or subacromial decompression...
September 14, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28917877/effects-of-hydrothermal-alkali-and-freezing-thawing-pre-treatments-on-modification-of-corn-starch-with-octenyl-succinic-anhydride
#4
Shujun Wang, Tiangui Li, Shuo Wang, Les Copeland
Pre-treatments by freezing/thawing (F/T) and hydrothermal-alkali (HA) were used in the modification of starch with octenyl succinic anhydride (OSA). In comparison with OSA-modified starch prepared without pre-treatment (degree of substitution, DS=0.0172; reaction efficiency, RE=73.9%), HA pre-treatment increased the DS of OSA-starch and RE of subsequent OSA modification (0.0185 and 79.7%, respectively). In contrast, F/T pre-treatment gave the opposite results (0.0152 and 65.5%, respectively). OSA modification markedly increased the viscosities but decreased the gelatinization parameters of native starch...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917039/in-vitro-translation-assays-for-selenocysteine-insertion
#5
Mark H Pinkerton, Paul R Copeland
The molecular characterization of the protein and RNA factors that are required for Sec incorporation in mammals has been largely carried out using in vitro translation systems specifically modified for this purpose. This chapter outlines the various systems and modifications that have been used to decipher the mechanism of Sec incorporation.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917036/selenocysteine-trna-ser-sec-the-central-component-of-selenoprotein-biosynthesis-isolation-identification-modification-and-sequencing
#6
Bradley A Carlson, Byeong Jae Lee, Petra A Tsuji, Paul R Copeland, Ulrich Schweizer, Vadim N Gladyshev, Dolph L Hatfield
The selenocysteine (Sec) tRNA([Ser]Sec) population consists of two isoforms that differ from each other by a single 2'-O-methylribosyl moiety at position 34 (Um34). These two isoforms, which are encoded in a single gene, Trsp, and modified posttranscriptionally, are involved individually in the synthesis of two subclasses of selenoproteins, designated housekeeping and stress-related selenoproteins. Techniques used in obtaining these isoforms for their characterization include extraction of RNA from mammalian cells and tissues, purifying the tRNA([Ser]Sec) population by one or more procedures, and finally resolving the two isoforms from each other...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28914059/physiochemical-characteristics-and-molecular-structures-for-digestible-carbohydrates-of-silages
#7
Basim Refat, Luciana Louzada Prates, Yaogeng Lei, David Christensen, John J McKinnon, Peiqiang Yu
The main objectives of this study were (1) to assess the magnitude of differences among new barley silage varieties (BS) selected for varying rates of in vitro NDFD digestibility (ivNDFD; Cowboy BS with higher ivNDFD , Copeland BS with intermediate ivNDFD and Xena BS with lower ivNDFD) as regards to their physiochemical features (energy), carbohydrate nutrient fractions and rumen digestive contents in dairy cows in comparison with a new corn silage hybrid (Pioneer 7213R), and (2) to identify the pattern of interactive association between the molecular structure of carbohydrates and digestible carbohydrates content...
September 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28905502/prevalence-trends-of-selected-major-birth-defects-a-multi-state-population-based-retrospective-study-united-states-1999-to-2007
#8
Amanda M St Louis, Keewan Kim, Marilyn L Browne, Gang Liu, Rebecca F Liberman, Wendy N Nembhard, Mark A Canfield, Glenn Copeland, Jane Fornoff, Russell S Kirby
BACKGROUND: We evaluated selected birth defects over a 9-year period to assess prevalence trends by selected maternal and infant factors. METHODS: Data were pooled from 11 population-based birth defects surveillance programs in the United States for children born between 1999 and 2007. Overall prevalence, as well as 3-year interval prevalence, was calculated for 26 specific birth defects, stratified by maternal age, maternal race/ethnicity, and infant sex. Average annual percent change (AAPC) was calculated for each birth defect...
September 14, 2017: Birth defects research
https://www.readbyqxmd.com/read/28904992/too-many-choices-confuse-patients-with-dementia
#9
R C Hamdy, J V Lewis, A Kinser, A Depelteau, R Copeland, T Kendall-Wilson, K Whalen
Choices are often difficult to make by patients with Alzheimer Dementia. They often become acutely confused when faced with too many options because they are not able to retain in their working memory enough information about the various individual choices available. In this case study, we describe how an essentially simple benign task (choosing a dress to wear) can rapidly escalate and result in a catastrophic outcome. We examine what went wrong in the patient/caregiver interaction and how that potentially catastrophic situation could have been avoided or defused...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/28904206/a-disease-associated-frameshift-mutation-in-caveolin-1-disrupts-caveolae-formation-and-function-through-introduction-of-a-de-novo-er-retention-signal
#10
Courtney A Copeland, Bing Han, Ajit Tiwari, Eric D Austin, James E Loyd, James D West, Anne K Kenworthy
Caveolin-1 (CAV1) is an essential component of caveolae and is implicated in numerous physiological processes. Recent studies have identified heterozygous mutations in the CAV1 gene in patients with pulmonary arterial hypertension (PAH), but the mechanisms by which these mutations impact caveolae assembly and contribute to disease remain unclear. To address this question, we examined the consequences of a familial PAH-associated frameshift mutation in CAV1, P158PfsX22, on caveolae assembly and function. We show that C-terminus of the CAV1 P158 protein contains a functional ER-retention signal that inhibits ER exit and caveolae formation and accelerates CAV1 turnover in Cav1(-/-) MEFs...
September 13, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28891124/dockground-a-comprehensive-data-resource-for-modeling-of-protein-complexes
#11
Petras J Kundrotas, Ivan Anishchenko, Taras Dauzhenka, Ian Kotthoff, Daniil Mnevets, Matthew M Copeland, Ilya A Vakser
Characterization of life processes at the molecular level requires structural details of protein interactions. The number of experimentally determined structures of protein-protein complexes accounts only for a fraction of known protein interactions. This gap in structural description of the interactome has to be bridged by modeling. An essential part of the development of structural modeling/docking techniques for protein interactions is databases of protein-protein complexes. They are necessary for studying protein interfaces, providing a knowledge base for docking algorithms, developing intermolecular potentials, search procedures, and scoring functions...
September 10, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28880738/military-sexual-trauma-and-obesity-among-women-veterans
#12
Nivedita Pandey, Samir N Ashfaq, Edward W Dauterive, Andrea A MacCarthy, Laurel A Copeland
BACKGROUND/OBJECTIVE: Posttraumatic stress disorder (PTSD), the experience of military sexual trauma (MST) that may contribute to PTSD, and obesity are three issues that complicate care for our population of new veterans. Our aim was to analyze the association of MST and diagnosed PTSD with obesity among female veterans. MATERIALS AND METHODS: Women 20-103 years old using the Veterans Health Administration (VA) in fiscal year 2014 (October 2013-September 2014) with diagnosis and body-mass data were identified in administrative databases (213,985 of 404,183 women)...
September 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28871150/intragastric-balloon-as-an-adjunct-to-lifestyle-programme-in-severely-obese-adolescents-impact-on-biomedical-outcomes-and-skeletal-health
#13
P Sachdev, L Reece, M Thomson, A Natarajan, R J Copeland, J K Wales, N P Wright
Intragastric Balloons are a temporary, reversible, and safer option compared to bariatric surgery to promote significant weight loss leading to improved metabolic outcomes. However due to subsequent weight regain, alternative procedures are now preferred in adults. In adolescents, more amenable to lifestyle change, balloons may be an alternative to less reversible procedures. Our aim was to assess the tolerability and efficacy of the intragastric balloon in severely obese adolescents and the impact of associated weight loss on biomedical outcomes (glucose metabolism, blood pressure, lipid profiles) and bone density...
September 5, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28869271/understanding-the-influence-of-low-frequency-vibrations-on-the-hydrogen-bonds-of-acetic-acid-and-acetamide-dimers
#14
Christopher Copeland, Omkaran Menon, D Majumdar, Szczepan Roszak, Jerzy Leszczynski
Low-frequency vibrations coupled to high-frequency modes are known to influence the hydrogen bond strengths in a weakly interacting dimer. In this context, various acetic acid and acetamide dimers were analyzed using Møller-Plesset second-order perturbation (MP2) and density functional theory (DFT)-based approaches with explicit anharmonicity corrections. The computed low-frequency fundamentals as well as the high-frequency modes, which were found to be related to hydrogen bonding (OH/NH stretching modes), were analyzed and their computed intensities were correlated with their hydrogen-bond strengths/binding energies...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28860611/impact-of-immunosuppression-on-the-metagenomic-composition-of-the-intestinal-microbiome-a-systems-biology-approach-to-post-transplant-diabetes
#15
M Bhat, E Pasini, J Copeland, M Angeli, S Husain, D Kumar, E Renner, A Teterina, J Allard, D S Guttman, A Humar
Solid organ transplantation (SOT) outcomes have continued to improve, although long-term use of immunosuppressants can lead to complications such as diabetes, compromising post-transplant outcomes. In this study, we have characterized the intestinal microbiome (IM) composition at the metagenomic level in the context of hyperglycemia induced by immunosuppressants. Sprague-Dawley rats were subjected to doses of tacrolimus and sirolimus that reliably induce hyperglycemia and an insulin-resistant state. Subsequent exposure to probiotics resulted in reversal of hyperglycemia...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28860240/genome-sequence-of-roseovarius-sp-strain-mctg156-2b-isolated-from-a-phytoplankton-net-trawl-on-the-scottish-west-coast
#16
Tony Gutierrez, William B Whitman, Marcel Huntemann, Alex Copeland, Amy Chen, Neha Vargese, Nikos C Kyrpides, Manoj Pillay, Natalia Ivanova, Natalia Mikhailova, Supratim Mukherjee, Dimitrios Stamatis, T B K Reddy, Chew Yee Ngan, Mansi Chovatia, Chris Daum, Nicole Shapiro, Tanja Woyke
Roseovarius sp. strain MCTG156(2b) was isolated from a phytoplankton net sample collected on the west coast of Scotland and was selected based on its ability to degrade polycyclic aromatic hydrocarbons. Here, we present the genome sequence of this strain, which is 5,113,782 bp, with 5,142 genes and an average G+C content of 60.7%.
August 31, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28858615/robotic-automation-of-in%C3%A2-vivo-two-photon-targeted-whole-cell-patch-clamp-electrophysiology
#17
Luca A Annecchino, Alexander R Morris, Caroline S Copeland, Oshiorenoya E Agabi, Paul Chadderton, Simon R Schultz
Whole-cell patch-clamp electrophysiological recording is a powerful technique for studying cellular function. While in vivo patch-clamp recording has recently benefited from automation, it is normally performed "blind," meaning that throughput for sampling some genetically or morphologically defined cell types is unacceptably low. One solution to this problem is to use two-photon microscopy to target fluorescently labeled neurons. Combining this with robotic automation is difficult, however, as micropipette penetration induces tissue deformation, moving target cells from their initial location...
August 30, 2017: Neuron
https://www.readbyqxmd.com/read/28856085/attainment-of-5-2-1-0-obesity-recommendations-in-preschool-aged-children
#18
Amrik Singh Khalsa, Roohi Kharofa, Nicholas J Ollberding, Laurie Bishop, Kristen A Copeland
Obesity prevention guidelines recommend children eat ≥ 5 servings of fruits and vegetables, view ≤ 2 h of screen time, participate in 1 h of physical activity, and consume 0 sugar-sweetened beverages daily, commonly known as '5-2-1-0'. We sought to determine: the extent to which preschool-aged children attending child care meet these guidelines, predictors of attainment, and associations of attainment with weight status. We analyzed in 2016, 24-hour dietary, physical activity, and screen time data collected in 2009-10 from 398 preschool-aged children in 30 child-care centers in Cincinnati, OH...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28854061/lassoing-skill-through-learner-choice
#19
Gabriele Wulf, Takehiro Iwatsuki, Brittney Machin, Jessica Kellogg, Clint Copeland, Rebecca Lewthwaite
The authors examined several issues related to the motor learning benefits resulting from giving learners choices. In 2 experiments, participants practiced a novel task, throwing a lasso. In Experiment 1, giving learners a choice ostensibly irrelevant to performance (color of mat under target) resulted in enhanced learning relative to a control group. The choice group also reported more positive affect. Experiment 2 compared the effectiveness of task-irrelevant (mat color) versus task-relevant (video demonstrations of the skill) choices...
August 30, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28847118/small-stories-in-defense-of-the-humble-case-report
#20
LETTER
Christopher S Graffeo, Avital Perry, Lucas P Carlstrom, William R Copeland, Kathryn M Van Abel, Michael J Link
No abstract text is available yet for this article.
September 2017: World Neurosurgery
keyword
keyword
53650
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"