keyword
MENU ▼
Read by QxMD icon Read
search

copeland

keyword
https://www.readbyqxmd.com/read/29152924/population-based-birth-defects-data-in-the-united-states-2010-2014-a-focus-on-gastrointestinal-defects
#1
Philip J Lupo, Jennifer L Isenburg, Jason L Salemi, Cara T Mai, Rebecca F Liberman, Mark A Canfield, Glenn Copeland, Sarah Haight, Sanjiv Harpavat, Adrienne T Hoyt, Cynthia A Moore, Wendy N Nembhard, Hoang N Nguyen, Rachel E Rutkowski, Amy Steele, C J Alverson, Erin B Stallings, Russell S Kirby
BACKGROUND: Gastrointestinal defects are a phenotypically and etiologically diverse group of malformations. Despite their combined prevalence and clinical impact, little is known about the epidemiology of these birth defects. Therefore, the objective of the 2017 National Birth Defects Prevention Network (NBDPN) data brief was to better describe the occurrence of gastrointestinal defects. METHODS: As part of the 2017 NBDPN annual report, 28 state programs provided additional data on gastrointestinal defects for the period 2010-2014...
November 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/29145839/structural-effects-of-intra-articular-tgf-%C3%AE-1-in-moderate-to-advanced-knee-osteoarthritis-mri-based-assessment-in-a-randomized-controlled-trial
#2
A Guermazi, G Kalsi, J Niu, M D Crema, R O Copeland, A Orlando, M J Noh, F W Roemer
BACKGROUND: To determine effects of allogeneic human chondrocytes expressing TGF-β1 (TG-C) on structural progression of MRI features of knee osteoarthritis over a 1 year period. METHODS: This phase II randomized controlled trial of TG-C included patients with moderate to advanced osteoarthritis. Patients were randomized to receive an intraarticular 3:1 mixture of non-transduced allogeneic human chondrocytes and TG-C or placebo. 3 T MRI was acquired for all patients at baseline and follow-up (3, 6 and 12 months)...
November 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29134166/anterior-extension-of-tumor-is-as-important-as-tumor-size-to-facial-nerve-outcome-and-extent-of-resection-for-vestibular-schwannomas
#3
Ricky H Wong, William R Copeland, Jeffrey T Jacob, Sananthan Sivakanthan, Jamie J Van Gompel, Harry van Loveren, Michael J Link, Siviero Agazzi
Objectives  We examined vestibular schwannoma tumor dimension and direction of growth to determine whether these correlate with facial nerve outcome as well as extent of resection (EOR). Design  Retrospective review of prospectively maintained databases. Participants  206 patients were a part of this study. Main Outcome Measures  Tumor dimensions were measured using preoperative magnetic resonance imaging, and a series of ratios were then calculated to further characterize tumor dimension. Regression analyses were performed to investigate correlation with facial nerve outcome and EOR...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29130932/p120-catenin-is-an-obligate-haploinsufficient-tumor-suppressor-in-intestinal-neoplasia
#4
Sarah P Short, Jumpei Kondo, Whitney G Smalley-Freed, Haruna Takeda, Michael R Dohn, Anne E Powell, Robert H Carnahan, Mary K Washington, Manish Tripathi, D Michael Payne, Nancy A Jenkins, Neal G Copeland, Robert J Coffey, Albert B Reynolds
p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an "obligatory" haploinsufficient tumor suppressor. Whereas monoallelic loss of p120 was associated with a significant increase in tumor multiplicity, loss of both alleles was never observed in tumors from these mice. Moreover, forced ablation of the second allele did not further enhance tumorigenesis, but instead induced synthetic lethality in combination with Apc loss of heterozygosity...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29126081/multiple-chronic-condition-profiles-and-survival-among-oldest-old-male-patients-with-hip-fracture
#5
Jinmyoung Cho, Eileen M Stock, I-Chia Liao, John E Zeber, Brian K Ahmedani, Rashmita Basu, Charlene C Quinn, Laurel A Copeland
To improve understanding of survival among very elderly male patients with surgically repaired hip fractures, this study applied classification techniques to multiple chronic conditions (MCC) then modeled survival by latent class. Veterans Health Administration (VHA)'s electronic medical records on male inpatients age 85-100 years (n=896) with hip fracture diagnosis and repair were used. MCC defined by Charlson and Elixhauser disorders, medications, demographic covariates, and 5 years follow-up survival were included...
October 28, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29109096/dhplc-elution-patterns-of-vdr-pcr-products-can-predict-prostate-cancer-susceptibility-in-african-american-men
#6
REVIEW
Robert L Copeland, Desta Beyene, Victor Apprey, Mohammad R Daremipouran, Tammey J Naab, Olakunle O Kassim, Yasmine M Kanaan
BACKGROUND/AIM: Denaturing high-performance liquid chromatography (DHPLC) is a technique that is used to detect mutations. The aim of the present study was to determine whether DHPLC elution patterns of vitamin D receptor (VDR) gene PCR products can serve as indicators of susceptibility to prostate cancer (PCa) risk. MATERIALS AND METHODS: DNA samples of PCa cases and controls were screened for mutations and/or polymorphisms in coding exons of VDR gene using DHPLC analysis...
November 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29100208/differential-exposure-and-acute-health-impacts-of-inhaled-solid-fuel-emissions-from-rudimentary-and-advanced-cookstoves-in-female-cd-1-mice
#7
Eugene A Gibbs-Flournoy, M Ian Gilmour, Mark Higuchi, James Jetter, Ingrid George, Lisa Copeland, Randy Harrison, Virginia C Moser, Janice A Dye
BACKGROUND: There is an urgent need to provide access to cleaner end user energy technologies for the nearly 40% of the world's population who currently depend on rudimentary cooking and heating systems. Advanced cookstoves (CS) are designed to cut emissions and solid-fuel consumption, thus reducing adverse human health and environmental impacts. STUDY PREMISE: We hypothesized that, compared to a traditional (Tier 0) three-stone (3-S) fire, acute inhalation of solid-fuel emissions from advanced natural-draft (ND; Tier 2) or forced-draft (FD; Tier 3) stoves would reduce exposure biomarkers and lessen pulmonary and innate immune system health effects in exposed mice...
October 31, 2017: Environmental Research
https://www.readbyqxmd.com/read/29100041/dna-polymerase-%C3%AE-a-missing-link-of-the-base-excision-repair-machinery-in-mammalian-mitochondria
#8
Rajendra Prasad, Melike Çağlayan, Da-Peng Dai, Cristina A Nadalutti, Ming-Lang Zhao, Natalie R Gassman, Agnes K Janoshazi, Donna F Stefanick, Julie K Horton, Rachel Krasich, Matthew J Longley, William C Copeland, Jack D Griffith, Samuel H Wilson
Mitochondrial genome integrity is fundamental to mammalian cell viability. Since mitochondrial DNA is constantly under attack from oxygen radicals released during ATP production, DNA repair is vital in removing oxidatively generated lesions in mitochondrial DNA, but the presence of a strong base excision repair system has not been demonstrated. Here, we addressed the presence of such a system in mammalian mitochondria involving the primary base lesion repair enzyme DNA polymerase (pol) β. Pol β was localized to mammalian mitochondria by electron microscopic-immunogold staining, immunofluorescence co-localization and biochemical experiments...
December 2017: DNA Repair
https://www.readbyqxmd.com/read/29096779/predicting-persistent-limited-and-delayed-problematic-cannabis-use-in-early-adulthood-findings-from-a-longitudinal-study
#9
Sherika Hill, Lilly Shanahan, E Jane Costello, William Copeland
OBJECTIVE: To identify risk profiles associated with patterns of problematic cannabis use in early adulthood. METHOD: Data came from 1,229 participants in the Great Smoky Mountains Study, a prospective 20-year cohort study from 1993 to 2015 that is representative of western North Carolina with yearly assessments conducted from ages 9 and 16 years, and assessments at ages 19, 21, 26, and 30 years. Patterns of problematic cannabis use (i.e., DSM-5 cannabis use disorder or daily use) in early adulthood included the following: nonproblematic use in late adolescence (ages 19-21) and early adulthood (ages 26-30); limited problematic use in late adolescence only; persistent problematic use in late adolescence and early adulthood; and delayed problematic use in early adulthood only...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29096778/adult-associations-of-childhood-suicidal-thoughts-and-behaviors-a-prospective-longitudinal-analysis
#10
William E Copeland, David B Goldston, E Jane Costello
OBJECTIVE: Suicidal thoughts and behavior (STBs) have their peak period of onset in adolescence, but little is known about how such behavior is associated with later functioning. The aim of this study is to test whether childhood STBs are related to adult psychiatric, suicidal, and functional outcomes. METHOD: This is a prospective, population-based community study of 1,420 participants assessed with structured interviews up to 7 times in childhood/adolescence (ages 9-16 years; 6,674 observations) for STBs including passive and active ideation, plans, and attempts...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29093768/draft-genome-sequence-of-marinobacterium-rhizophilum-cl-yj9-t-dsm-18822-t-isolated-from-the-rhizosphere-of-the-coastal-tidal-flat-plant-suaeda-japonica
#11
Dong Han Choi, Gwang Ii Jang, Alla Lapidus, Alex Copeland, T B K Reddy, Supratim Mukherjee, Marcel Huntemann, Neha Varghese, Natalia Ivanova, Manoj Pillay, Brian J Tindall, Markus Göker, Tanja Woyke, Hans-Peter Klenk, Nikos C Kyrpides, Byung Cheol Cho
The genus Marinobacterium belongs to the family Alteromonadaceae within the class Gammaproteobacteria and was reported in 1997. Currently the genus Marinobacterium contains 16 species. Marinobacterium rhizophilum CL-YJ9(T) was isolated from sediment associated with the roots of a plant growing in a tidal flat of Youngjong Island, Korea. The genome of the strain CL-YJ9(T) was sequenced through the Genomic Encyclopedia of Type Strains, Phase I: KMG project. Here we report the main features of the draft genome of the strain...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29093449/abnormal-contractility-in-human-heart-myofibrils-from-patients-with-dilated-cardiomyopathy-due-to-mutations-in-ttn-and-contractile-protein-genes
#12
Petr G Vikhorev, Natalia Smoktunowicz, Alex B Munster, O'Neal Copeland, Sawa Kostin, Cecile Montgiraud, Andrew E Messer, Mohammad R Toliat, Amy Li, Cristobal G Dos Remedios, Sean Lal, Cheavar A Blair, Kenneth S Campbell, Maya Guglin, Ralph Knoll, Steven B Marston
Dilated cardiomyopathy (DCM) is an important cause of heart failure. Single gene mutations in at least 50 genes have been proposed to account for 25-50% of DCM cases and up to 25% of inherited DCM has been attributed to truncating mutations in the sarcomeric structural protein titin (TTNtv). Whilst the primary molecular mechanism of some DCM-associated mutations in the contractile apparatus has been studied in vitro and in transgenic mice, the contractile defect in human heart muscle has not been studied. In this study we isolated cardiac myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D and MYH7 E1426K) and measured their contractility and passive stiffness in comparison with donor heart muscle as a control...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29084087/salsalate-as-an-adjunctive-treatment-for-psychopathology-and-cognition-in-patients-with-schizophrenia-a-pilot-study
#13
Yanli Luo, Fang Liu, Radhika Natarajan, Nawras Shukair, Paul Copeland, Xiaoduo Fan
This pilot study examined the effect of adjunctive salsalate on psychopathology and cognition in patients with schizophrenia. This was a 12-week, open-label trial of salsalate (1.5 g, twice per day) in patients with schizophrenia. Psychopathology, cognition, and daily function were assessed at baseline and week 12 using various rating scales. Blood levels of inflammatory markers including white blood cell count, high-sensitivity C-reactive protein, and interleukin-6 levels were also measured. Eight patients completed the study...
October 27, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29080369/ciprofloxacin-versus-levofloxacin-for-prophylaxis-during-hematopoietic-stem-cell-transplantation
#14
Vanessa Copeland, Milena McLaughlin, Steven Trifilio
The objective of the current retrospective study is to compare differences in rate of breakthrough infections for ciprofloxacin versus levofloxacin prophylaxis in an autologous HSCT patients treated for multiple myeloma. This was a retrospective, cohort study comparing autologous hematopoietic stem-cell transplant (HSCT) recipients treated for multiple myeloma who received ciprofloxacin prophylaxis versus levofloxacin prophylaxis. A total of 297 patients, 143 levofloxacin and 154 ciprofloxacin-treated were included...
October 28, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29070081/understanding-the-experience-of-initiating-community-based-physical-activity-and-social-support-by-people-with-serious-mental-illness-a-systematic-review-using-a-meta-ethnographic-approach
#15
Helen Quirk, Helen Crank, Deborah Harrop, Emma Hock, Robert Copeland
BACKGROUND: People with long-term serious mental illness live with severe and debilitating symptoms that can negatively influence their health and quality of life, leading to outcomes such as premature mortality, morbidity and obesity. An interplay of social, behavioural, biological and psychological factors is likely to contribute to their poor physical health. Participating in regular physical activity could bring symptomatic improvements, weight loss benefits, enhanced wellbeing and when undertaken in a community-based group setting can yield additional, important social support benefits...
October 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29069514/multiple-rna-structures-affect-translation-initiation-and-uga-redefinition-efficiency-during-synthesis-of-selenoprotein-p
#16
Marco Mariotti, Sumangala Shetty, Lisa Baird, Sen Wu, Gary Loughran, Paul R Copeland, John F Atkins, Michael T Howard
Gene-specific expansion of the genetic code allows for UGA codons to specify the amino acid selenocysteine (Sec). A striking example of UGA redefinition occurs during translation of the mRNA coding for the selenium transport protein, selenoprotein P (SELENOP), which in vertebrates may contain up to 22 in-frame UGA codons. Sec incorporation at the first and downstream UGA codons occurs with variable efficiencies to control synthesis of full-length and truncated SELENOP isoforms. To address how the Selenop mRNA can direct dynamic codon redefinition in different regions of the same mRNA, we undertook a comprehensive search for phylogenetically conserved RNA structures and examined the function of these structures using cell-based assays, in vitro translation systems, and in vivo ribosome profiling of liver tissue from mice carrying genomic deletions of 3' UTR selenocysteine-insertion-sequences (SECIS1 and SECIS2)...
October 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29067426/effect-of-robotic-assisted-vs-conventional-laparoscopic-surgery-on-risk-of-conversion-to-open-laparotomy-among-patients-undergoing-resection-for-rectal-cancer-the-rolarr-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
David Jayne, Alessio Pigazzi, Helen Marshall, Julie Croft, Neil Corrigan, Joanne Copeland, Phil Quirke, Nick West, Tero Rautio, Niels Thomassen, Henry Tilney, Mark Gudgeon, Paolo Pietro Bianchi, Richard Edlin, Claire Hulme, Julia Brown
Importance: Robotic rectal cancer surgery is gaining popularity, but limited data are available regarding safety and efficacy. Objective: To compare robotic-assisted vs conventional laparoscopic surgery for risk of conversion to open laparotomy among patients undergoing resection for rectal cancer. Design, Setting, and Participants: Randomized clinical trial comparing robotic-assisted vs conventional laparoscopic surgery among 471 patients with rectal adenocarcinoma suitable for curative resection conducted at 29 sites across 10 countries, including 40 surgeons...
October 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29059366/sbcddb-sleeping-beauty-cancer-driver-database-for-gene-discovery-in-mouse-models-of-human-cancers
#18
Justin Y Newberg, Karen M Mann, Michael B Mann, Nancy A Jenkins, Neal G Copeland
Large-scale oncogenomic studies have identified few frequently mutated cancer drivers and hundreds of infrequently mutated drivers. Defining the biological context for rare driving events is fundamentally important to increasing our understanding of the druggable pathways in cancer. Sleeping Beauty (SB) insertional mutagenesis is a powerful gene discovery tool used to model human cancers in mice. Our lab and others have published a number of studies that identify cancer drivers from these models using various statistical and computational approaches...
October 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29058898/reaction-of-co2-with-groups-4-and-6-transition-metal-oxide-clusters
#19
Luis A Flores, Julia G Murphy, William B Copeland, David A Dixon
Density functional theory (DFT) and coupled cluster theory (CCSD(T)) were used to study the addition of CO2 to group 4 (MO2)n and group 6 (MO3)n (n = 1, 2, 3) nanoclusters. The structures and energetics arising from Lewis acid-base addition (physisorption) and formation of CO3(2-) (chemisorption) of CO2 to these clusters were predicted. Physisorption and chemisorption of CO2 are predicted to be thermodynamically allowed for group 4 (MO2)n clusters, with chemisorption being more favored energetically. Correlations of the ligand binding energies (LBEs) for the group 4 clusters are made with the fluoride affinities and M-O and M═O bond strengths of the clusters...
November 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29051913/patients-with-dementia-are-easy-victims-to-predators
#20
R C Hamdy, J V Lewis, R Copeland, A Depelteau, A Kinser, T Kendall-Wilson, K Whalen
Patients with dementia, especially Alzheimer's disease and particularly those in early stages, are susceptible to become victims of predators: Their agnosia (see Case 1) prevents them from detecting and accurately interpreting subtle signals that otherwise would have alerted them that they are about to fall for a scam. Furthermore, their judgment is impaired very early in the disease process, often before other symptoms manifest themselves and usually before a diagnosis is made. Patients with early stages of dementia are therefore prime targets for unscrupulous predators, and it behooves caregivers and health care professionals to ensure the integrity of these patients...
January 2017: Gerontology & Geriatric Medicine
keyword
keyword
53650
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"