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https://www.readbyqxmd.com/read/29324863/correction-orion-detecting-regions-of-the-human-non-coding-genome-that-are-intolerant-to-variation-using-population-genetics
#1
Ayal B Gussow, Brett R Copeland, Ryan S Dhindsa, Quanli Wang, Slavé Petrovski, William H Majoros, Andrew S Allen, David B Goldstein
[This corrects the article DOI: 10.1371/journal.pone.0181604.].
2018: PloS One
https://www.readbyqxmd.com/read/29317398/active-for-health-rotherham-be-active-to-stay-healthy
#2
Rebecca Atchinson, Gabbi Frith, Amy Roden, Robert J Copeland, Lindsey J Reece
No abstract text is available yet for this article.
January 9, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29298081/paratracheal-paraseptal-emphysema-and-expiratory-central-airway-collapse-in-smokers
#3
Carla R Copeland, Hrudaya Nath, Nina L J Terry, Carla G Wilson, Young-Il Kim, David A Lynch, Sandeep Bodduluri, J Michael Wells, Mark T Dransfield, Alejandro A Díaz, George R Washko, Marilyn G Foreman, Surya P Bhatt
RATIONALE: Expiratory central airway collapse (ECAC) is associated with respiratory morbidity independent of underlying lung disease. However, not all smokers develop ECAC and the etiology of ECAC in adult smokers is unclear. Paraseptal emphysema in the paratracheal location, by untethering airway walls, may predispose smokers to developing ECAC. OBJECTIVE: To evaluate whether paratracheal paraseptal emphysema (paratracheal PSE) is associated with ECAC. METHODS: We analyzed paired inspiratory and expiratory computed tomography scans from participants enrolled in a multicenter study (COPDGene) of smokers aged 45-80 years...
January 3, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29273127/role-of-behavioral-health-in-management-of-pediatric-atopic-dermatitis
#4
REVIEW
Mary D Klinnert, Genery Booster, Mandy Copeland, Jennifer Moyer Darr, Lisa J Meltzer, Michael Miller, Alyssa Oland, Shauna Perry, Brian K Wise, Bruce G Bender
OBJECTIVE: To describe the behavioral components and complications in treating pediatric patients with atopic dermatitis (AD) and the critical role of behavioral health professionals in addressing disease impact and behavioral aspects of disease management for these patients and families. DATA SOURCES: Studies and review articles were selected from medical and psychology databases for relevance to pertinent topics. RESULTS: AD has significant negative effects in affected individuals and their families on quality of life, behavioral, emotional, and sleep disturbances, and family functioning...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29233521/the-elements-of-translational-chemical-biology
#5
REVIEW
Robert A Copeland, P Ann Boriack-Sjodin
A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these molecules.
November 27, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29232128/mechanisms-underlying-the-formation-of-complexes-between-maize-starch-and-lipids
#6
Chen Chao, Jinglin Yu, Shuo Wang, Les Copeland, Shujun Wang
This study aimed to reveal the mechanism of formation of complexes between native maize starch (NMS) and different types of lipids, namely palmitic acid (PA), monopalmitate glycerol (MPG), dipalmitate glycerol (DPG) and tripalmitate glycerol (TPG). The complexing index followed the order of MPG (96.3%) > PA (41.8%) > TPG (8.3%) > DPG (1.1%), indicating that MPG formed more complexes with NMS than PA, and that few complexes were formed between NMS and DPG and TPG. The NMS-PA complex presented higher thermal transition temperatures and lower enthalpy change than the NMS-MPG complex, indicating that although MPG formed more starch complexes, they had less stable crystalline structures than the complex between NMS and PA...
December 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29215235/the-2017-retirement-confidence-survey-many-workers-lack-retirement-confidence-and-feel-stressed-about-retirement-preparations
#7
Lisa Greenwald, Craig Copeland, Jack VanDerhei
No abstract text is available yet for this article.
March 21, 2017: EBRI Issue Brief
https://www.readbyqxmd.com/read/29215233/individual-retirement-account-balances-contributions-withdrawals-and-asset-allocation-longitudinal-results-2010%C3%A2-2014-the-ebri-ira-database
#8
Craig Copeland
No abstract text is available yet for this article.
January 17, 2017: EBRI Issue Brief
https://www.readbyqxmd.com/read/29204765/approaches-to-multidimensional-health-in-representations-of-islamic-themes-among-black-male-characters-in-american-film-and-television
#9
Kameron J Copeland
Historically, representations of Islamic themes in media narratives of Black men have been characterized by personal transformations in the midst of surviving in crime-ridden inner city areas. These young Black men are usually at-risk due to their statuses as Black, economically disadvantaged men. Beginning with Malcolm X and Alex Haley's The Autobiography of Malcolm X, the Black male Islamic redemption narrative has become a common theme in Black popular culture, as it is usually supplemented with unique methods of confronting the various dimensions of health...
December 5, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/29203698/beautiful-piles-of-bones-an-interview-with-2017-genetics-society-of-america-medal-recipient-david-m-kingsley
#10
David M Kingsley
The Genetics Society of America Medal is awarded to an individual for outstanding contributions to the field of genetics in the last 15 years. Recipients of the GSA Medal are recognized for elegant and highly meaningful contributions to modern genetics, exemplifying the ingenuity of GSA membership. The 2017 recipient is David M. Kingsley, whose work in mouse, sticklebacks, and humans has shifted paradigms about how vertebrates evolve. Kingsley first fell in love with genetics in graduate school, where he worked on receptor mediated endocytosis with Monty Krieger...
December 2017: Genetics
https://www.readbyqxmd.com/read/29195773/cognitive-deficits-in-bipolar-disorders-implications-for-emotion
#11
REVIEW
Isabela M M Lima, Andrew D Peckham, Sheri L Johnson
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome...
November 21, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29195034/birth-defect-survival-for-hispanic-subgroups
#12
Keila N Lopez, Wendy N Nembhard, Ying Wang, Gang Liu, James E Kucik, Glenn Copeland, Suzanne M Gilboa, Russell S Kirby, Mark Canfield
BACKGROUND: Previous studies demonstrate that infant and childhood mortality differ among children with birth defects by maternal race/ethnicity, but limited mortality information is published for Hispanic ethnic subgroups. METHODS: We performed a retrospective cohort study using data for children with birth defects born to Hispanic mothers during 1999-2007 from 12 population-based state birth defects surveillance programs. Deaths were ascertained through multiple sources...
December 1, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29186148/a-case-control-collapsing-analysis-identifies-epilepsy-genes-implicated-in-trio-sequencing-studies-focused-on-de-novo-mutations
#13
Xiaolin Zhu, Raghavendra Padmanabhan, Brett Copeland, Joshua Bridgers, Zhong Ren, Sitharthan Kamalakaran, Ailbhe O'Driscoll-Collins, Samuel F Berkovic, Ingrid E Scheffer, Annapurna Poduri, Davide Mei, Renzo Guerrini, Daniel H Lowenstein, Andrew S Allen, Erin L Heinzen, David B Goldstein
Trio exome sequencing has been successful in identifying genes with de novo mutations (DNMs) causing epileptic encephalopathy (EE) and other neurodevelopmental disorders. Here, we evaluate how well a case-control collapsing analysis recovers genes causing dominant forms of EE originally implicated by DNM analysis. We performed a genome-wide search for an enrichment of "qualifying variants" in protein-coding genes in 488 unrelated cases compared to 12,151 unrelated controls. These "qualifying variants" were selected to be extremely rare variants predicted to functionally impact the protein to enrich for likely pathogenic variants...
November 29, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29167819/successful-amplification-of-dna-aboard-the-international-space-station
#14
Anna-Sophia Boguraev, Holly C Christensen, Ashley R Bonneau, John A Pezza, Nicole M Nichols, Antonio J Giraldez, Michelle M Gray, Brandon M Wagner, Jordan T Aken, Kevin D Foley, D Scott Copeland, Sebastian Kraves, Ezequiel Alvarez Saavedra
As the range and duration of human ventures into space increase, it becomes imperative that we understand the effects of the cosmic environment on astronaut health. Molecular technologies now widely used in research and medicine will need to become available in space to ensure appropriate care of astronauts. The polymerase chain reaction (PCR) is the gold standard for DNA analysis, yet its potential for use on-orbit remains under-explored. We describe DNA amplification aboard the International Space Station (ISS) through the use of a miniaturized miniPCR system...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/29164928/clozapine-diabetes-mellitus-cardiovascular-risk-and-mortality-results-of-a-21-year-naturalistic-study-in-patients-with-schizophrenia-and-schizoaffective-disorder
#15
Katlyn L Nemani, M Claire Greene, Melissa Ulloa, Brenda Vincenzi, Paul M Copeland, Sulaiman Al-Khadari, David C Henderson
The goal of this 21-year naturalistic study of clozapine treated patients was to examine the cardiovascular risk factors following clozapine initiation and resultant mortality estimates from cardiovascular disease. Data was collected from medical records of clozapine treated patients with schizophrenia or schizoaffective disorder from January 1992 to February 2012. Demographics, clozapine dosage and laboratory results were extracted at 12-month intervals. At clozapine initiation, the mean age of 96 patients was 36...
November 22, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29164172/hallucinations-are-real-to-patients-with-dementia
#16
R C Hamdy, A Kinser, J V Lewis, R Copeland, A Depelteau, T Kendall-Wilson, K Whalen
In this case study, we present a patient with preexistent posttraumatic stress disorder and psychosis who has been recently diagnosed with Dementia with Lewy Bodies. He is experiencing vivid hallucinations. What went wrong between him and his wife as a result of these hallucinations is presented. Alternative actions that could have been used are suggested. Objectives: At the end of this case study, readers will know the following:The characteristic clinical features of Dementia with Lewy Bodies (DLB)...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29161108/a-roundtable-discussion-thawing-out-healthcare-technology-s-special-snowflake-cybersecurity-challenges
#17
Robert D Jensen, Scot Copeland, Stephanie Domas, Rick Hampton, Ken Hoyme, Michelle Jump, Inhel Rekik, Suzanne Schwartz, Eugene Vasserman
No abstract text is available yet for this article.
September 2, 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29161058/trends-in-daily-cannabis-use-among-cigarette-smokers-united-states-2002-2014
#18
Renee D Goodwin, Lauren R Pacek, Jan Copeland, Scott J Moeller, Lisa Dierker, Andrea Weinberger, Misato Gbedemah, Michael J Zvolensky, Melanie M Wall, Deborah S Hasin
OBJECTIVES: To estimate changes in the prevalence of daily cannabis use among current, former, and never cigarette smokers from 2002 to 2014 in the United States. METHODS: The National Survey on Drug Use and Health is a nationally representative cross-sectional study conducted annually among persons aged 12 years and older in the United States. RESULTS: Daily cannabis use occurs nearly exclusively among nondaily and daily cigarette smokers compared with former and never smokers (8...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29159815/effectiveness-of-interventions-for-breast-cancer-screening-in-african-american-women-a-meta-analysis
#19
Valire Carr Copeland, Yoo Jung Kim, Shaun M Eack
OBJECTIVE: The purpose of this study was to report the results of a meta-analysis conducted on the effects of clinical trials in breast cancer screening for African American women between 1997 and 2017. DATA SOURCES: Articles published in English and in the United States, between January 1997 and March 2017, were eligible for inclusion if they (1) conducted psychosocial, behavioral, or educational interventions designed to increase screening mammography rates in predominantly African American women of all ages; (2) utilized a randomized, controlled trial (RCT) design; and (3) reported quantitative screening rates following the intervention...
November 21, 2017: Health Services Research
https://www.readbyqxmd.com/read/29152924/population-based-birth-defects-data-in-the-united-states-2010-2014-a-focus-on-gastrointestinal-defects
#20
Philip J Lupo, Jennifer L Isenburg, Jason L Salemi, Cara T Mai, Rebecca F Liberman, Mark A Canfield, Glenn Copeland, Sarah Haight, Sanjiv Harpavat, Adrienne T Hoyt, Cynthia A Moore, Wendy N Nembhard, Hoang N Nguyen, Rachel E Rutkowski, Amy Steele, C J Alverson, Erin B Stallings, Russell S Kirby
BACKGROUND: Gastrointestinal defects are a phenotypically and etiologically diverse group of malformations. Despite their combined prevalence and clinical impact, little is known about the epidemiology of these birth defects. Therefore, the objective of the 2017 National Birth Defects Prevention Network (NBDPN) data brief was to better describe the occurrence of gastrointestinal defects. METHODS: As part of the 2017 NBDPN annual report, 28 state programs provided additional data on gastrointestinal defects for the period 2010-2014...
November 1, 2017: Birth Defects Research
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