Pedro Marchant, Erika Vivanco, Andrés Silva, Jan Nevermann, Ignacio Fuentes, Boris Barrera, Carolina Otero, Iván L Calderón, Fernando Gil, Juan A Fuentes
The rise of multidrug-resistant bacteria is a global concern, leading to a renewed reliance on older antibiotics like polymyxins as a last resort. Polymyxins, cationic cyclic peptides synthesized nonribosomally, feature a hydrophobic acyl tail and positively charged residues. Their antimicrobial mechanism involves initial interaction with Gram-negative bacterial outer-membrane components through polar and hydrophobic interactions. Outer membrane vesicles (OMVs), nano-sized proteoliposomes secreted from the outer membrane of Gram-negative bacteria, play a crucial role in tolerating harmful molecules, including cationic peptides such as polymyxins...
2024: Frontiers in Microbiology