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https://www.readbyqxmd.com/read/28747375/evaluation-of-the-rapid-polymyxin-np-test-for-polymyxin-b-resistance-detection-using-enterobacter-cloacae-and-enterobacter-aerogenes-isolates
#1
Shelby Simar, Diane Sibley, Deborah Ashcraft, George Pankey
Background: Polymyxin resistance is an increasing problem worldwide. Currently, determining susceptibility to polymyxins is problematic and lengthy. Polymyxins diffuse poorly into agar, potentially giving inaccurate disk diffusion and Etest results. A rapid screening test (2 h) for detection of polymyxin-resistance in Enterobacteriaceae, developed by Nordmann and Poirel (Rapid Polymyxin NP Test, 2016), detects glucose metabolization in the presence of polymyxins E and B via pH-induced color change. Sensitivity/specificity were 99...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28743810/polymyxin-combinations-combat-escherichia-coli-harboring-mcr-1-and-blandm-5-preparation-for-a-postantibiotic-era
#2
Zackery P Bulman, Liang Chen, Thomas J Walsh, Michael J Satlin, Yuli Qian, Jürgen B Bulitta, Charles A Peloquin, Patricia N Holden, Roger L Nation, Jian Li, Barry N Kreiswirth, Brian T Tsuji
The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as an important indicator that the golden era of antibiotics is under serious threat. We assessed the bacterial killing of 15 different FDA-approved antibiotics alone and in combination with polymyxin B in time-killing experiments against Escherichia coli MCR1_NJ, the first reported isolate in the United States to coharbor mcr-1 and a New Delhi metallo-β-lactamase gene (blaNDM-5)...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28726622/mcr-1-and-blakpc-3-in-escherichia-coli-sequence-type-744-after-meropenem-and-colistin-therapy-portugal
#3
Marta Tacão, Rafael Dos Santos Tavares, Pedro Teixeira, Inês Roxo, Elmano Ramalheira, Sónia Ferreira, Isabel Henriques
Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-blaKPC-3, already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resistance to carbapenems and polymyxins after therapy with drugs from both classes.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28724927/dual-functionality-nanobioconjugates-targeting-intracellular-bacteria-in-cancer-cells-with-enhanced-antimicrobial-activity
#4
Rohini Singh, Smita Patil, Neetu Singh, Shalini Gupta
Bacterial drug resistance has emerged as a serious global threat mandating the development of novel methodologies that allow facile modulation of antimicrobial action in a controlled fashion. Conjugating antibiotics to nanoparticles helps to meet this goal by increasing the drug's overall avidity, bioavailability and easier internalisation into mammalian cells, targeting bacteria that otherwise escape antibacterial action by host cell-localisation. We used polymyxin B sulfate (PMB) and sushi peptide as model drugs against Gram-negative bacteria and established their enhanced antimicrobial activity on Escherichia coli (E...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724555/susceptibility-testing-for-the-polymyxins-two-steps-back-three-steps-forward
#5
Shawn Vasoo
Optimizing and standardizing susceptibility testing for the polymyxins have become a pressing issue given the rise multidrug-resistant Gram-negative bacilli. Recently both CLSI-EUCAST have recommended broth microdilution (BMD) (without polysorbate) as the reference method for polymyxin susceptibility testing. In this issue, Chew et al. (doi: https://doi.org/10.1128JCM.00268-17.) compare the performance of three commercial BMD panels and the Etest to reference BMD for polymyxin B and colistin, on 76 Enterobacteriaceae isolates (21 mcr-1 positive)...
July 19, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28721845/combination-of-polymyxin-b-and-meropenem-eradicates-persister-cells-from-acinetobacter-baumannii-strains-in-exponential-growth
#6
Stephanie W Gallo, Carlos Alexandre S Ferreira, Sílvia D de Oliveira
No abstract text is available yet for this article.
July 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28716359/predictors-of-polymyxin-b-treatment-failure-in-gram-negative-healthcare-associated-infections-among-critically-ill-patients
#7
Bahiah Ismail, Mohd Nazri Shafei, Azian Harun, Saedah Ali, Mahamarowi Omar, Zakuan Zainy Deris
BACKGROUND: With increasing prevalence and spread of multidrug resistant Gram-negative infections, parenteral polymyxins resurged in clinical practice. The primary aim of the study was to determine the predictors of treatment failure and in-hospital mortality among critically ill patients treated with polymyxin B. METHODS: Demographic data, underlying diseases, procedures and details on polymyxin B therapy were retrospectively analyzed in a cohort of 84 patients who received intravenous polymyxin B in an intensive care unit from 2010 to 2014...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28714872/immunomodulatory-activity-of-octenyl-succinic-anhydride-modified-porang-amorphophallus-oncophyllus-glucomannan-on-mouse-macrophage-like-j774-1-cells-and-mouse-primary-peritoneal-macrophages
#8
Sellen Gurusmatika, Kosuke Nishi, Eni Harmayani, Yudi Pranoto, Takuya Sugahara
Porang is a local plant of Indonesia, which has a high content of glucomannan. In this study, porang glucomannan (PG) was esterified with octenyl succinic anhydride (OSA) to enhance emulsion properties to be widely used in food industry. OSA-modified PG (OSA-PG) enhanced the phagocytosis activity of macrophage-like J774.1 cells and mouse peritoneal macrophages. In addition, OSA-PG increased the production of IL-6 and TNF-α by enhancing their gene expression. Immunoblot analysis displayed that OSA-PG tended to activate both nuclear factor-κB and mitogen-activated protein kinase cascades...
July 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28713357/extensively-drug-resistant-klebsiella-pneumoniae-causing-nosocomial-bloodstream-infections-in-china-molecular-investigation-of-antibiotic-resistance-determinants-informing-therapy-and-clinical-outcomes
#9
Wenzi Bi, Haiyang Liu, Rhys A Dunstan, Bin Li, Von Vergel L Torres, Jianming Cao, Lijiang Chen, Jonathan J Wilksch, Richard A Strugnell, Trevor Lithgow, Tieli Zhou
The rise in diversity of antimicrobial resistance phenotypes seen in Klebsiella pneumoniae is becoming a serious antibiotic management problem. We sought to investigate the molecular characteristics and clinical implications of extensively drug-resistant (XDR) K. pneumoniae isolated from different nosocomial bloodstream infections (BSIs) patients from July 2013 to November 2015. Even in combination treatment, meropenem did not protect against mortality of BSIs patients (P = 0.015). In contrast, tigecycline in combination with other antimicrobial agents significantly protected against mortality (P = 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28711508/virulent-and-pathogenic-features-on-the-cronobacter-sakazakii-polymyxin-resistant-pmr-mutant-strain-s-3
#10
Xuerui Bao, Ling Yang, Lequn Chen, Bing Li, Lin Li, Yanyan Li, Zhenbo Xu
Cronobacter sakazakii is a well-known opportunistic pathogen responsible for necrotizing enterocolitis, meningitis and septicaemia in the premature, immunocompromised infants and neonates. This pathogen possesses various virulence factors and regulatory systems, and pmrA/pmrB regulatory system has been identified in a variety of bacterial species. The current study aims to investigate role of pmrA gene in the pathogenicity and virulence characteristics of Cronobacter sakazakii using whole genome sequencing and RNA-seq...
July 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28711154/western-diet-induced-dysbiosis-in-farnesoid-x-receptor-knockout-mice-causes-persistent-hepatic-inflammation-after-antibiotic-treatment
#11
Prasant K Jena, Lili Sheng, Hui-Xin Liu, Karen M Kalanetra, Annie Mirsoian, William J Murphy, Samuel W French, Viswanathan V Krishnan, David A Mills, Yu-Jui Yvonne Wan
Patients who have liver cirrhosis and liver cancer also have reduced farnesoid X receptor (FXR). The current study analyzes the effect of diet through microbiota that affect hepatic inflammation in FXR knockout (KO) mice. Wild-type and FXR KO mice were on a control (CD) or Western diet (WD) for 10 months. In addition, both CD- and WD-fed FXR KO male mice, which had hepatic lymphocyte and neutrophil infiltration, were treated by vancomycin, polymyxin B, and Abx (ampicillin, neomycin, metronidazole, and vancomycin)...
July 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28700048/distribution-of-the-bla-oxa-bla-veb-1-and-bla-ges-1-genes-and-resistance-patterns-of-esbl-producing-pseudomonas-aeruginosa-isolated-from-hospitals-in-tehran-and-qazvin-iran
#12
Sahar Amirkamali, Taghi Naserpour-Farivar, Khadijeh Azarhoosh, Amir Peymani
INTRODUCTION: Pseudomonas aeruginosa is one of the most common nosocomial pathogens. The emergence of extended spectrum β-lactamases (ESBLs) has been increasingly reported as a major clinical concern worldwide. The main aim of the present study was to determine the distribution of bla OXA, bla PER-1, bla VEB-1, and bla GES-1 genes among ESBL-producing P. aeruginosa isolated from two distinct provinces in Iran. METHODS: In this study, a total of 75 (27.5%) ESBL-producing isolates were identified from 273 P...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28696672/magnetic-extraction-of-acinetobacter-baumannii-using-colistin-functionalized-%C3%AE-fe2o3-au-core-shell-composite-nanoclusters
#13
Charleson S Bell, Raquel Mejias, Sinead Miller, Jasmine Greer, Mark McClain, Timothy L Cover, Todd D Giorgio
Acinetobacter baumannii is a gram-negative bacterium of increasing concern due to its virulence and persistence in combat and healthcare environments. The incidence of both community-acquired and nosocomial A. baumannii infections is on the rise in foreign and domestic healthcare facilities. Treatment options are limited due to the acquisition of multi-drug resistance to the few effective antibiotics. Currently, the most effective pharmaceutically-based treatment for multi-drug-resistant A. baumannii infections is the antibiotic colistin (polymyxin E)...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28695731/investigating-the-interaction-of-octapeptin-a3-with-model-bacterial-membranes
#14
Mei-Ling Han, Hsin-Hui Shen, Karl A Hansford, Elena K Schneider, Sivashangarie Sivanesan, Kade D Roberts, Philip E Thompson, Anton P Le Brun, Yan Zhu, Marc-Antoine Sani, Frances Separovic, Mark A T Blaskovich, Mark A Baker, Samuel M Moskowitz, Matthew A Cooper, Jian Li, Tony Velkov
Octapeptins are cyclic lipopeptides with a broader spectrum of activity against fungi and polymyxin-resistant Gram-negative and Gram-positive bacteria. In the present study, we investigated the interaction of octapeptin A3 with asymmetric outer membrane models of Gram-negative pathogen Pseudomonas aeruginosa using neutron reflectometry, together with fluorimetric and calorimetry methods. For the first time, our neutron reflectometry results reveal that the interaction of octapeptin A3 with the Gram-negative outer membrane involves an initial transient polar interaction with the phospholipid and lipid A headgroups, followed by the penetration of the entire octapeptin molecule into the fatty acyl core of the outer membrane...
July 11, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28693659/what-s-lurking-around-the-corner-polymyxin-b-resistance-among-klebsiella-pnemoniae-carbapenemase-producing-enterobacteriaceae-and-others-as-a-burden-of-use
#15
Leandro Reus Rodrigues Perez
No abstract text is available yet for this article.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28692823/high-hiv-infection-prevalence-in-a-group-of-men-who-have-sex-with-men-msm
#16
Raquel Maria Cardoso Torres, Marly Marques da Cruz, André Reynaldo Santos Périssé, Denise Ribeiro Franqueira Pires
OBJECTIVE: To evaluate, by phenotypic and genotypic parameters, the presence of virulence and resistance factors in clinical Acinetobacter baumannii strains and verify the correlation between these variables. SETTINGS: Observational study conducted in an Universitary Hospital in Belo Horizonte, Brazil. METHODS: The confirmation of A. baumannii-calcoaceticus complex was performed by blaOXA51 detection, through the polymerase chain reaction (PCR) multiplex, as well as to investigate the presence of other oxacillinases (blaOXA23, 24, 58)...
July 7, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28690852/is-polymyxin-b-immobilized-fiber-column-ineffective-for-septic-shock-a-discussion-on-the-press-release-for-euphrates-trial
#17
Toshiaki Iba, Lucy Fowler
The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from "Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock (EUPHRATES)" trial has been announced as a press release. According to that report, less than a 5% mortality difference was recognized in the "per protocol population" (n = 244, 31.9 vs. 36.9%) and the decrease was not statistically significant. However, among the patients in refractory shock with a multiple organ dysfunction score of more than 9 and an EAA between 0...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28683827/expanding-landscapes-of-the-diversified-mcr-1-bearing-plasmid-reservoirs
#18
Qingjing Wang, Jian Sun, Jun Li, Youfa Ding, Xing-Ping Li, Jingxia Lin, Bachar Hassan, Youjun Feng
BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinical use. METHODS: The mcr-1-harboring plasmids were acquired from swine and human Escherichia coli isolated in China, from 2015 to 2016, and subjected to Illumina PacBio RSII and Hi-Seq2000 for full genome sequencing...
July 6, 2017: Microbiome
https://www.readbyqxmd.com/read/28678874/molecular-characteristics-of-mcr-1-carrying-plasmids-and-new-mcr-1-variant-recovered-from-polyclonal-clinical-escherichia-coli-from-argentina-and-canada
#19
Nathalie Tijet, Diego Faccone, Melina Rapoport, Christine Seah, Fernando Pasterán, Paola Ceriana, Ezequiel Albornoz, Alejandra Corso, Alejandro Petroni, Roberto G Melano
We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins...
2017: PloS One
https://www.readbyqxmd.com/read/28676713/effect-of-the-meropenem-mic-on-the-killing-activity-of-meropenem-and-polymyxin-b-in-combination-against-kpc-producing-klebsiella-pneumoniae
#20
Brandon Kulengowski, Jeffrey J Campion, David J Feola, David S Burgess
No abstract text is available yet for this article.
July 5, 2017: Journal of Antibiotics
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