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https://www.readbyqxmd.com/read/29351645/dosimetry-during-percutaneous-coronary-interventions-of-chronic-total-occlusions
#1
Jérémie Dabin, Joren Maeremans, Danielle Berus, Werner Schoonjans, Giulia Tamborino, Jo Dens, Peter Kayaert
Percutaneous coronary interventions (PCI) of coronary chronic total occlusions (CTO) increase the risk of high radiation exposure for both the patient and the cardiologist. This study evaluated the maximum dose to the patients' skin (MSD) and the exposure of the cardiologists during CTO-PCI. Moreover, the efficiency of radioprotective drapes to reduce cardiologist exposure was assessed. Patient dose was measured during 31 procedures; dose to the cardiologist's extremities were measured during 65 procedures, among which 31 were performed with radioprotective drapes...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29347492/elucidating-fluctuating-diffusivity-in-center-of-mass-motion-of-polymer-models-with-time-averaged-mean-square-displacement-tensor
#2
Tomoshige Miyaguchi
There have been increasing reports that the diffusion coefficient of macromolecules depends on time and fluctuates randomly. Here a method is developed to elucidate this fluctuating diffusivity from trajectory data. Time-averaged mean-square displacement (MSD), a common tool in single-particle-tracking (SPT) experiments, is generalized to a second-order tensor with which both magnitude and orientation fluctuations of the diffusivity can be clearly detected. This method is used to analyze the center-of-mass motion of four fundamental polymer models: the Rouse model, the Zimm model, a reptation model, and a rigid rodlike polymer...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347382/aging-in-mortal-superdiffusive-l%C3%A3-vy-walkers
#3
Helena Stage
A growing body of literature examines the effects of superdiffusive subballistic movement premeasurement (aging or time lag) on observations arising from single-particle tracking. A neglected aspect is the finite lifetime of these Lévy walkers, be they proteins, cells, or larger structures. We examine the effects of aging on the motility of mortal walkers, and discuss the means by which permanent stopping of walkers may be categorized as arising from "natural" death or experimental artifacts such as low photostability or radiation damage...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345245/isolating-long-wavelength-fluctuation-from-structural-relaxation-in-two-dimensional-glass-cage-relative-displacement
#4
Hayato Shiba, Peter Keim, Takeshi Kawasaki
It has recently been revealed that long-wavelength fluctuation exists in two- dimensional (2D) glassy systems, having the same origin as that given by the Mermin- Wagner theorem for 2D crystalline solids. Here, extending our recent studies, we discuss the quantification of long-wavelength acoustic fluctuation of a lightly supercooled liquid. This fluctuation can be estimated by subtracting the mean-squared displacement (MSD) of particles relative to its cage, represented by the cage-relative MSD, from the original particle MSD...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29336615/pharmacokinetic-bioequivalence-safety-and-acceptability-of-ornibel%C3%A2-a-new-polymer-composition-contraceptive-vaginal-ring-etonogestrel-ethinylestradiol-11-00-3-474%C3%A2-mg-compared-with-nuvaring%C3%A2-etonogestrel-ethinylestradiol-11-7-2-7%C3%A2-mg
#5
Jaime Algorta, Maria Diaz, Raquel de Benito, Marc Lefebvre, Eric Sicard, Milton Furtado, Pedro Antonio Regidor, Celestino Ronchi
OBJECTIVE: To show the clinical development of Ornibel® (ExeltisHealthcare, Spain) a contraceptive vaginal ring manufactured with a new polymer composition and containing etonogestrel/ethinylestradiol, compared to Nuvaring® (MSD, Spain). SUBJECTS AND METHODS: Randomised, single dose, 2-period, 2-sequence, 2-stage crossover, comparative bioavailability study conducted in 40 healthy female subjects. All subjects received both treatments for 28 days in each of two periods, separated by a 28 days washout...
January 16, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29336205/prediction-of-natalizumab-anti-drug-antibodies-persistency
#6
Florian Deisenhammer, Marlies Jank, Anna Lauren, Anders Sjödin, Malin Ryner, Anna Fogdell-Hahn, Claudia Sievers, Raija Lindberg, Poul Erik Jensen, Finn Sellebjerg, Louis Christodoulou, Mary Birchler, Marc Pallardy, Michael Auer, Roland Liblau
BACKGROUND: Anti-drug antibodies (ADA) against natalizumab develop early during treatment. ADA persistency is defined by two consecutive positive results as performed by the current qualitative ELISA assay (positive/negative). Very little is known about the magnitude of the natalizumab ADA response and persistency. DESIGN/METHODS: We developed a highly sensitive natalizumab ADA titration assay on the Meso Scale Discovery (MSD) platform and a pharmacokinetic (PK) assay...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29331728/the-effect-of-bioadhesive-on-the-interfacial-compatibility-and-pervaporation-performance-of-composite-membranes-by-md-and-gcmc-simulation
#7
Baohe Wang, Yan Nie, Jing Ma
Combing molecular dynamics (MD) and Grand Canonical Monte Carlo (GCMC) simulation, the effect of bioadhesive transition layer on the interfacial compatibility of the pervaporation composite membranes, and the pervaporation performance toward penetrant molecules were investigated. In our previous experimental study, the structural stability and permeability selectivity of the composite membranes were considerably enhanced by the introduction of bioadhesive carbopol (CP). In the present study, the interfacial compatibility and the interfacial energies between the chitosan (CS) separation layer, CP transition layer and the support layer were investigated, respectively...
January 5, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29330391/impact-of-antithymocyte-globulin-doses-in-reduced-intensity-conditioning-before-allogeneic-transplantation-from-matched-sibling-donor-for-patients-with-acute-myeloid-leukemia-a-report-from-the-acute-leukemia-working-party-of-european-group-of-bone-marrow-transplantation
#8
Raynier Devillier, Myriam Labopin, Patrice Chevallier, Marie-Pierre Ledoux, Gérard Socié, Anne Huynh, Jean-Henri Bourhis, Jean-Yves Cahn, Gabrielle Roth-Guepin, Ghulam Mufti, Déborah Desmier, Mauricette Michallet, Nathalie Fegueux, Fabio Ciceri, Fréderic Baron, Didier Blaise, Arnon Nagler, Mohamad Mohty
Antithymocyte globulin (ATG) is commonly used for graft-vs.-host disease (GVHD) prophylaxis in unrelated donor allogeneic transplantation (Allo-HSCT). However, its use is still controversial in matched sibling donor (MSD) Allo-HSCT, notably after reduced intensity conditioning (RIC). ATG dose may influence the outcome, explaining in part the discordant conclusions in MSD Allo-HSCT. We, therefore, analyzed the impact of ATG doses in patients with acute myeloid leukemia in first complete remission undergoing RIC Allo-HSCT from a MSD...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29319149/pr%C3%A3-valence-et-d%C3%A3-terminants-des-troubles-musculosquelettiques-des-membres-sup%C3%A3-rieurs-chez-les-artisans-tunisiens
#9
Amira Omrane, Imene Kacem, Meriem Heni, Adnene Henchi, Sana Elmhami, Irtyah Merchaoui, Awatef Kraiem, Taoufik Khalfallah, Lamia Bouzgarrou
Musculoskeletal disorders (MSDs) of the upper limbs are a major occupational health problem. We report the results of a cross-sectional survey of 334 craftsmen from the governorate of Monastir in Tunisia. The objectives of this study were to assess the prevalence of MSDs among these workers and determine their risk factors. A pre-established questionnaire based on the Nordic MSD questionnaires, Karassik and the one developed by Malchaire in 2000 was used. In the 12 months prior to the survey, the prevalence of MSDs was 92...
January 2, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29316935/estimating-the-returns-to-united-kingdom-publicly-funded-musculoskeletal-disease-research-in-terms-of-net-value-of-improved-health-outcomes
#10
Matthew Glover, Erin Montague, Alexandra Pollitt, Susan Guthrie, Stephen Hanney, Martin Buxton, Jonathan Grant
BACKGROUND: Building on an approach applied to cardiovascular and cancer research, we estimated the economic returns from United Kingdom public- and charitable-funded musculoskeletal disease (MSD) research that arise from the net value of the improved health outcomes in the United Kingdom. METHODS: To calculate the economic returns from MSD-related research in the United Kingdom, we estimated (1) the public and charitable expenditure on MSD-related research in the United Kingdom between 1970 and 2013; (2) the net monetary benefit (NMB), derived from the health benefit in quality adjusted life years (QALYs) valued in monetary terms (using a base-case value of a QALY of £25,000) minus the cost of delivering that benefit, for a prioritised list of interventions from 1994 to 2013; (3) the proportion of NMB attributable to United Kingdom research; and (4) the elapsed time between research funding and health gain...
January 10, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29284995/prevalence-of-musculoskeletal-disorders-among-dentists-in-iran-a-systematic-review
#11
Narges Sadat Shams-Hosseini, Tahereh Vahdati, Zeinab Mohammadzadeh, Ali Yeganeh, Somayeh Davoodi
Introduction: Musculoskeletal disorders (MSD) have become significant problems for all health care workers especially dentists. This systematic review provides prevalence of MSD in dentists of Iran. Material and Methods: In this study all published literatures about MSD in Iranian dentists were selected without any time limits or other restrictions. However, it was found that the studies about MSD among Iranian dentist are very low. Results: The results of literatures investigations show that the prevalence was between 0...
December 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29284969/musculoskeletal-disorders-and-mental-health-related-issues-as-occupational-hazards-among-dental-practitioners-in-salem-city-a-cross-sectional-study
#12
Vanita D Revankar, Yadav Chakravarthy, S Naveen, Arun Senthamil Selvan, Aarthi Ganapathy, A S Prasad
Background: Like in any other profession, dental surgeons are also afflicted by many occupational health hazards such as Musculoskeletal disorders (MSD) and mental health related issues. Aims: To assess the distribution of MSD and mental health related issues amidst dentists in Salem City according to age, sex and number of working hours per week. Objectives: A survey was organized to check the rate of occurrence of these occupational health hazards among dental practitioners in Salem city...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29282463/prevalence-of-work-related-musculoskeletal-disorders-among-surgeons-and-interventionalists-a-systematic-review-and-meta-analysis
#13
Sherise Epstein, Emily H Sparer, Bao N Tran, Qing Z Ruan, Jack T Dennerlein, Dhruv Singhal, Bernard T Lee
Importance: Physicians in procedural specialties are at high risk for work-related musculoskeletal disorders (MSDs). This has been called "an impending epidemic" in the context of the looming workforce shortage; however, prevalence estimates vary by study. Objectives: To estimate the prevalence of work-related MSDs among at-risk physicians and to evaluate the scope of preventive efforts. Data Sources and Study Selection: Systematic search in MEDLINE (Ovid), Embase (Elsevier), Web of Science, PubMed (National Center for Biotechnology Information), and 2 clinical trial registries, without language restriction, for studies reporting on the prevalence and prevention of work-related MSDs among at-risk physicians published until December 2016...
December 27, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29280092/classifying-clinical-notes-with-pain-assessment-using-machine-learning
#14
Samah Jamal Fodeh, Dezon Finch, Lina Bouayad, Stephen L Luther, Han Ling, Robert D Kerns, Cynthia Brandt
Pain is a significant public health problem, affecting millions of people in the USA. Evidence has highlighted that patients with chronic pain often suffer from deficits in pain care quality (PCQ) including pain assessment, treatment, and reassessment. Currently, there is no intelligent and reliable approach to identify PCQ indicators inelectronic health records (EHR). Hereby, we used unstructured text narratives in the EHR to derive pain assessment in clinical notes for patients with chronic pain. Our dataset includes patients with documented pain intensity rating ratings > = 4 and initial musculoskeletal diagnoses (MSD) captured by (ICD-9-CM codes) in fiscal year 2011 and a minimal 1 year of follow-up (follow-up period is 3-yr maximum); with complete data on key demographic variables...
December 26, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29274621/anti-inflammatory-activity-of-cannabinoid-receptor-2-ligands-in-primary-hpdl-fibroblasts
#15
Ammaar H Abidi, Chaela S Presley, Mustafa Dabbous, David A Tipton, Suni M Mustafa, Bob M Moore
OBJECTIVES: Approximately 65 million adults in the US have periodontitis, causing tooth loss and decreased quality of life. Cannabinoids modulate immune responses, and endocannabinoids are prevalent during oral cavity inflammation. Targets for intervention in periodontal inflammation are cannabinoid type 1 and 2 receptors (CB1R, CB2R), particularly CB2R because its levels increase during inflammation. We previously demonstrated that SMM-189 (CB2R inverse agonist) decreased pro-inflammatory cytokine production in primary microglial cells...
December 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29274274/identifying-return-to-work-trajectories-using-sequence-analysis-in-a-cohort-of-workers-with-work-related-musculoskeletal-disorders
#16
Christopher McLeod, Eline Reiff, Esther Maas, Ute Bültmann
Objectives This study aimed to identify return-to-work (RTW) trajectories among workers with work-related musculoskeletal disorders (MSD) and examine the associations between different MSD and these RTW trajectories. Methods We used administrative workers' compensation data to identify accepted MSD lost-time claims with an injury date between 2010-2012 in British Columbia, Canada. Cox regression analyses were used to investigate differences in time to RTW between MSD. Validated day-to-day calendar measures of four RTW states (sickness absence, modified RTW, RTW, and non-RTW) were grouped into RTW trajectories spanning a one-year period using sequence analysis...
December 23, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29246372/john-i-ingle-dds-msd-1919-2017-the-legacy-of-an-extraordinary-leader
#17
Leif K Bakland, Ilan Rotstein
No abstract text is available yet for this article.
January 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29240109/carry-free-full-symbol-one-step-modified-signed-digit-addition
#18
Shuai Kong, Junjie Peng, Youyi Fu, Xinyu Wei
Optical computing has advantages over electronic computing because it can carry much more information and process more data bits. Providing that carry-look-ahead is applied in optical computing in the same way electronic computing accomplishes addition calculation, it will be more inefficient because of the delay caused by a large number of serial carries. On the basis of the research on relations among the augend, addend, results, and the redundancy of modified signed-digit (MSD) number, the implementation method of carry-free one-step MSD addition is presented...
December 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29229410/pre-weaning-maternal-separation-increases-eating-later-in-life-in-male-and-female-offspring-but-increases-brainstem-dopamine-receptor-1a-and-2a-only-in-males
#19
Julliet Araújo de Souza, Matilde Cesiana da Silva, Rhowena Jane Barbosa de Matos, Larissa Cavalcanti do Amaral Almeida, Luana Cruz Beltrão, Felipe Leitão de Souza, Raul Manhães de Castro, Sandra Lopes de Souza
Maternal separation stress (MS) is a model of early life stress performed by the separation between dam and pups in the first days of life. This model has been associated with eating behavior and dopaminergic system abnormal phenotypes. This study aims to investigate whether maternal separation in the light or dark phase of the circadian cycle promotes phenotypic adjustments in the eating behavior and the dopamine system in both males and females. Lactating Wistar rats were separated from their litters from postnatal day 1 (PND 1) to PND 14 for 6 h in the light or dark phase of the circadian cycle...
December 8, 2017: Appetite
https://www.readbyqxmd.com/read/29211071/molecular-dynamics-simulation-of-geminal-dicationic-ionic-liquids-cn-mim-2-ntf2-2-structural-and-dynamical-properties
#20
Majid Moosavi, Fatemeh Khashei, Elaheh Sedghamiz
In this work, the structural and dynamical properties of two imidazolium-based geminal dicationic ionic liquids (GDILs), i.e. [Cn(mim)2][NTf2]2 with n = 3 and 5, have been studied to obtain a fundamental understanding of the molecular basis of the macroscopic and microscopic properties of the bulk liquid phase. To achieve this purpose, molecular dynamics (MD) simulation, density functional theory (DFT) and atoms in molecule (AIM) methods were used. Interaction energies, charge transfers and hydrogen bonds between the cation and anions of each studied GDIL were investigated by DFT calculations and also AIM...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
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