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https://www.readbyqxmd.com/read/29777843/underexpansion-of-wallstents%C3%A2-in-the-treatment-of-nonthrombotic-iliac-vein-lesions
#1
Jacob E Mandel, Yuriy Ostrozhynskyy, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: Iliac vein stenting is increasingly being used in the treatment of venous insufficiency for patients with nonthrombotic iliac vein lesions (NIVL). We have noticed that many stents do not deploy to the expected stent area as designated by the manufactured diameter. The purpose of this study was to evaluate the dynamics of Wallstent® expansion in the iliocaval system. METHODS: Retrospective analysis of all patients with NIVL who were treated with iliac vein stenting using Wallstents®...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29766227/noncontrast-computed-tomography-factors-predictive-of-extracorporeal-shock-wave-lithotripsy-outcomes-in-patients-with-pancreatic-duct-stones
#2
Ri Liu, Weiwei Su, Jing Gong, Yu Zhang, Jianping Lu
PURPOSE: To assess the usefulness of factors unique to NCCT for the prediction of ESWL outcomes in patients with pancreatic duct stones. MATERIALS AND METHODS: We retrospectively evaluated 148 patients with multiple PDS who had undergone ESWL therapy. All patients received an examination for NCCT both before and after ESWL. The following parameters were measured and recorded: patient characteristics including sex and age; NCCT parameters including mean stone length, mean stone volumes before and after ESWL, mean value of CT attenuation, standard deviation of CT attenuation, variation coefficient of CT attenuation, skin-to-stone distance, and pancreatic duct diameter; ESWL outcome indexes including stone clearance rate calculated using the formula [Formula: see text], and the number of ESWL sessions...
May 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29755609/towards-an-eu-measure-of-child-deprivation
#3
Anne-Catherine Guio, David Gordon, Eric Marlier, Hector Najera, Marco Pomati
This paper proposes a new measure of child material and social deprivation (MSD) in the European Union (EU) which includes age appropriate child-specific information available from the thematic deprivation modules included in the 2009 and 2014 waves of the "EU Statistics on Income and Living Conditions" (EU-SILC). It summarises the main results of the in-depth analysis of these two datasets, identifies an optimal set of robust children MSD items and recommends a child-specific MSD indicator for use by EU countries and the European Commission in their regular social monitoring...
2018: Child Indicators Research
https://www.readbyqxmd.com/read/29747605/gender-dependent-association-between-sleep-duration-and-overweight-incidence-in-chinese-school-children-a-national-follow-up-study
#4
Muqing Cao, Yanna Zhu, Xiuhong Li, Yajun Chen, Jun Ma, Jin Jing
BACKGROUND: The relationship between sleep duration and overweight risk remains unexplored among Chinese children. This study aims to evaluate this association in a national investigation with school-aged population. METHODS: There were 18,302 normal weight children in this Chinese national study which conducted during 2013-2014 included in the research. Anthropometric measurements were performed both at baseline and after 6-9 month. Sleep duration, physical activity, food intake and social economic information were collected by self-report questionnaire...
May 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29733318/combining-microfluidics-and-microrheology-to-determine-rheological-properties-of-soft-matter-during-repeated-phase-transitions
#5
Matthew D Wehrman, Melissa J Milstrey, Seth Lindberg, Kelly M Schultz
The microstructure of soft matter directly impacts macroscopic rheological properties and can be changed by factors including colloidal rearrangement during previous phase changes and applied shear. To determine the extent of these changes, we have developed a microfluidic device that enables repeated phase transitions induced by exchange of the surrounding fluid and microrheological characterization while limiting shear on the sample. This technique is µ2 rheology, the combination of microfluidics and microrheology...
April 19, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29728143/measurement-error-of-mean-sac-diameter-and-crown-rump-length-among-pregnant-women-at-mulago-hospital-uganda
#6
Sam Ali, Rosemary Kusaba Byanyima, Sam Ononge, Jerry Ictho, Jean Nyamwiza, Emmanuel Lako Ernesto Loro, John Mukisa, Angella Musewa, Annet Nalutaaya, Ronald Ssenyonga, Ismael Kawooya, Benjamin Temper, Achilles Katamba, Joan Kalyango, Charles Karamagi
BACKGROUND: Ultrasonography is essential in the prenatal diagnosis and care for the pregnant mothers. However, the measurements obtained often contain a small percentage of unavoidable error that may have serious clinical implications if substantial. We therefore evaluated the level of intra and inter-observer error in measuring mean sac diameter (MSD) and crown-rump length (CRL) in women between 6 and 10 weeks' gestation at Mulago hospital. METHODS: This was a cross-sectional study conducted from January to March 2016...
May 4, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29726622/improved-stent-expansion-with-prolonged-compared-with-short-balloon-inflation-a-meta-analysis
#7
Marwan Saad, Mahesh Bavineni, Barry F Uretsky, Srikanth Vallurupalli
BACKGROUND: Despite evidence from individual studies suggesting that prolonged inflation improves coronary stent expansion, relatively shorter inflation times are commonly employed in clinical practice. METHODS: We performed an electronic search of PubMed, Web of Science, Cochrane, and CINAHL databases to retrieve outcome studies comparing prolonged versus short inflation times during stent deployment. Outcomes studied included minimal stent diameter (MSD) and minimal stent area (MSA)...
May 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29721565/capturing-the-effect-of-pf-3-c-2-f-5-3-vs-pf-6-flexible-anion-vs-rigid-and-scaled-charge-vs-unit-on-the-transport-properties-of-bmim-based-ionic-liquids-a-comparative-md-study
#8
Mohammad H Kowsari, Soraya Ebrahimi
Comprehensive molecular dynamics simulations are performed to study the average single-particle dynamics and the transport properties of 1-butyl-3-methylimidazolium hexafluorophosphate, [bmim][PF6], and 1-butyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [bmim][FAP], ionic liquids (ILs) at 400 K. We applied one of the most widely used nonpolarizable all-atom force fields for ILs, both with the original unit (±1) charges on each ion and with the partial charges uniformly scaled to 80-85%, taking into account the average polarizability and tracing the experimentally compatible transport properties...
May 3, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29717691/probability-of-major-depression-diagnostic-classification-using-semi-structured-versus-fully-structured-diagnostic-interviews
#9
Brooke Levis, Andrea Benedetti, Kira E Riehm, Nazanin Saadat, Alexander W Levis, Marleine Azar, Danielle B Rice, Matthew J Chiovitti, Tatiana A Sanchez, Pim Cuijpers, Simon Gilbody, John P A Ioannidis, Lorie A Kloda, Dean McMillan, Scott B Patten, Ian Shrier, Russell J Steele, Roy C Ziegelstein, Dickens H Akena, Bruce Arroll, Liat Ayalon, Hamid R Baradaran, Murray Baron, Anna Beraldi, Charles H Bombardier, Peter Butterworth, Gregory Carter, Marcos H Chagas, Juliana C N Chan, Rushina Cholera, Neerja Chowdhary, Kerrie Clover, Yeates Conwell, Janneke M de Man-van Ginkel, Jaime Delgadillo, Jesse R Fann, Felix H Fischer, Benjamin Fischler, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G Greeno, Brian J Hall, John Hambridge, Patricia A Harrison, Ulrich Hegerl, Leanne Hides, Stevan E Hobfoll, Marie Hudson, Thomas Hyphantis, Masatoshi Inagaki, Khalida Ismail, Nathalie Jetté, Mohammad E Khamseh, Kim M Kiely, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Laura Marsh, Anthony McGuire, Sherina Mohd Sidik, Tiago N Munhoz, Kumiko Muramatsu, Flávia L Osório, Vikram Patel, Brian W Pence, Philippe Persoons, Angelo Picardi, Alasdair G Rooney, Iná S Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Christina M van der Feltz-Cornelis, Henk C van Weert, Paul A Vöhringer, Jennifer White, Mary A Whooley, Kirsty Winkley, Mitsuhiko Yamada, Yuying Zhang, Brett D Thombs
BACKGROUND: Different diagnostic interviews are used as reference standards for major depression classification in research. Semi-structured interviews involve clinical judgement, whereas fully structured interviews are completely scripted. The Mini International Neuropsychiatric Interview (MINI), a brief fully structured interview, is also sometimes used. It is not known whether interview method is associated with probability of major depression classification.AimsTo evaluate the association between interview method and odds of major depression classification, controlling for depressive symptom scores and participant characteristics...
May 2, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29706451/in-search-of-decoding-the-syntax-of-the-bioelements-in-human-hair-a-critical-overview
#10
Berislav Momčilović, Juraj Prejac, Anatoly Viktorovich Skalny, Ninoslav Mimica
The principles and practice of assessing the human body nutritional status or its environmental exposure through hair bioelement analysis are presented; herein the term "bioelements" is used as a common denominator for the major elements, trace elements and ultra-trace elements that are found in the human body. The accumulation of bioelements in the hair followed the statistical Power Law and the resulting sigmoid curve can be zoned into five regions in the ascending order of abundance (Low, Marginal, Adequate, High, and Excessive)...
April 12, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29705916/a-population-of-wheat-multiple-synthetic-derivatives-an-effective-platform-to-explore-harness-and-utilize-genetic-diversity-of-aegilops-tauschii-for-wheat-improvement
#11
Yasir Serag Alnor Gorafi, June-Sik Kim, Awad Ahmed Elawad Elbashir, Hisashi Tsujimoto
The multiple synthetic derivatives platform described in this study will provide an opportunity for effective utilization of Aegilops tauschii traits and genes for wheat breeding. Introducing genes from wild relatives is the best option to increase genetic diversity and discover new alleles necessary for wheat improvement. A population harboring genomic fragments from the diploid wheat progenitor Aegilops tauschii Coss. in the background of bread wheat (Triticum aestivum L.) was developed by crossing and backcrossing 43 synthetic wheat lines with the common wheat cultivar Norin 61...
April 28, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29702652/impact-of-lower-challenge-doses-of-enterotoxigenic-escherichia-coli-on-clinical-outcome-intestinal-colonization-and-immune-responses-in-adult-volunteers
#12
Subhra Chakraborty, Clayton Harro, Barbara DeNearing, Jessica Brubaker, Sean Connor, Nicole Maier, Len Dally, Jorge Flores, A Louis Bourgeois, Richard Walker, David A Sack
A reliable and effective human challenge model is needed to help down-select the most promising ETEC vaccines currently under development. Such a model would need to reliably induce diarrhea in a high proportion of volunteers using the lowest possible inoculum to maximize safety and sensitivity. Previously we validated a challenge model that utilized a dose of 2x107 CFU of ETEC strain H10407 (LT+, ST+, CFA/I+ and O78+) to induce attack rates for moderate to severe diarrhea (MSD) of ~60-70%. Here we detail efforts to further refine the model in an attempt to determine if a lower challenge dose of H10407 can be used...
April 27, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29700898/development-and-stability-of-a-heat-stable-formulation-of-carbetocin-for-the-prevention-of-postpartum-haemorrhage-for-use-in-low-and-middle-income-countries
#13
Mattias Malm, Ingbritt Madsen, Johan Kjellström
Postpartum haemorrhage is a leading cause of maternal death worldwide. Oxytocin, currently the drug of choice for prevention of PPH, requires constant refrigeration. In pursuit of an alternative medicine, Ferring Pharmaceuticals have developed a heat-stable formulation of carbetocin, an oxytocin analogue. This study aimed to define that formulation, and to investigate its stability under ICH climate zone IV conditions (30°C/75% relative humidity) for at least 3 years and at extreme temperatures, such as 60°C, for shorter periods of time...
April 27, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29689168/comparing-flow-cytometry-qbeads-plexscreen-assays-with-other-immunoassays-for-determining-multiple-analytes
#14
Mei Ding, Anders Cavallin, Nils-Olov Hermansson, Pia Berntsson, Lisa Jinton, Sandra Rodrigo Blomqvist
Immunoassays, utilizing the affinity of antibodies to their antigens, are powerful techniques and have been widely used for quantifying analytes, such as cytokines, in biological samples in the clinic and in drug discovery. Various immunoassays have been developed to fit for different purposes. Recently, bead-based flow cytometry assays have emerged as interesting options for multiplex quantification of analytes. In this study, we compared high-throughput flow cytometry multiplex iQue QBeads PlexScreen assays with several other commonly used immunoassays, including MSD, Luminex, ELISA, HTRF, and AlphaLISA assays...
April 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29686862/tryptophan-metabolic-profile-in-term-and-preterm-breast-milk-implications-for-health
#15
Louise O'Rourke, Gerard Clarke, Aoife Nolan, Claire Watkins, Timothy G Dinan, Catherine Stanton, R Paul Ross, Cornelius Anthony Ryan
Breast milk is the only source of the essential amino acid tryptophan (TRP) in breast-fed infants. Low levels of TRP could have implications for infant neurodevelopment. The objectives of the present study were to compare the relationship of TRP and its neuroactive pathway metabolites kynurenine (Kyn) and kynurenic acid (KynA) in preterm and term expressed breast milk (EBM) in the first 14 d following birth, and the relationship of TRP metabolism to maternal stress and immune status. A total of twenty-four mothers were recruited from Cork University Maternity Hospital: twelve term (>38 weeks) and twelve preterm (<35 weeks)...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29683394/impact-of-4-deltamethrin-impregnated-dog-collars-on-the-prevalence-and-incidence-of-canine-visceral-leishmaniasis
#16
Thaís Aparecida Kazimoto, Sthenia Santos Albano Amora, Fabiano Borges Figueiredo, Jamille Maia E Magalhães, Yannara Barbosa Nogueira Freitas, Maressa Laíse Reginaldo Sousa, Anne Emanuelle Câmara da Silva Melo, Monique Paiva Campos, Nilza Dutra Alves, Guilherme Loureiro Werneck
In Brazil, visceral leishmaniasis is caused by the protozoan Leishmania infantum, primarily transmitted by Lutzomyia longipalpis and with the dog as its main urban reservoir. This study aims to evaluate the effectiveness of 4% deltamethrin-impregnated dog collars (DMC) DIC, Scalibor® 65 cm model and MSD manufacturer, on the prevalence and incidence of canine visceral leishmaniasis (CVL) and on the rate of infection of sandflies by L. infantum. The research was conducted in two areas of the municipality Mossoró, State of Rio Grande do Norte in Northeast of Brazil...
April 23, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29681974/baicalin-downregulates-rlrs-signaling-pathway-to-control-influenza-a-virus-infection-and-improve-the-prognosis
#17
Peng Pang, Ke Zheng, Sizhi Wu, Huachong Xu, Li Deng, Yucong Shi, Xiaoyin Chen
The objective of this study is to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus (IAV) infection. PCR and western blot were used to measure the changes of some key factors in RLRs signaling pathway. MSD electrochemiluminescence was used to measure the expression of pulmonary inflammatory cytokines including IFN- γ , TNF- α , IL-1 β , IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, and KC/GRO. Flow cytometry was used to detect the proportion of Th1, Th2, Th17, and Treg...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29679774/comparable-results-of-autologous-and-allogeneic-haematopoietic-stem-cell-transplantation-for-adults-with-philadelphia-positive-acute-lymphoblastic-leukaemia-in-first-complete-molecular-remission-an-analysis-by-the-acute-leukemia-working-party-of-the-ebmt
#18
Sebastian Giebel, Myriam Labopin, Michael Potter, Xavier Poiré, Henrik Sengeloev, Gerard Socié, Anne Huynh, Boris V Afanasyev, Urs Schanz, Olle Ringden, Peter Kalhs, Dietrich W Beelen, Antonio M Campos, Tamás Masszi, Jonathan Canaani, Mohamad Mohty, Arnon Nagler
BACKGROUND: Allogeneic haematopoietic stem cell transplantation (alloHSCT) is considered a standard treatment for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL) achieving complete remission after induction containing tyrosine kinase inhibitors (TKIs). METHODS: We retrospectively compared results of myeloablative alloHSCT from either matched sibling donor (MSD) or unrelated donor (URD) with autologous (auto) HSCT for adults with Ph+ ALL in molecular remission, treated between 2007 and 2014...
June 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29678809/delayed-immune-reconstitution-after-allogeneic-transplantation-increases-the-risks-of-mortality-and-chronic-gvhd
#19
Nelli Bejanyan, Claudio G Brunstein, Qing Cao, Aleksandr Lazaryan, Xianghua Luo, Julie Curtsinger, Rohtesh S Mehta, Erica Warlick, Sarah A Cooley, Bruce R Blazar, Jeffrey S Miller, Daniel Weisdorf, John E Wagner, Michael R Verneris
Slow immune reconstitution is a major obstacle to the successful use of allogeneic hematopoietic cell transplantation (allo-HCT). As matched sibling donor (MSD) allo-HCT is regarded as the gold standard, we evaluated the pace of immune reconstitution in 157 adult recipients of reduced-intensity conditioning followed by MSD peripheral blood HCT (n = 68) and compared these to recipients of umbilical cord blood (UCB; n = 89). At day 28, UCB recipients had fewer natural killer (NK) cells than MSD recipients, but thereafter, NK cell numbers (and their subsets) were higher in UCB recipients...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29676732/donated-chemical-probes-for-open-science
#20
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart Mj Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia Yi Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose...
April 20, 2018: ELife
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