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Mohit Sharma, Raghu Radhakrishnan
Limited mouth opening (LMO) in Oral Submucous Fibrosis (OSF) has been attributed to both the submucosal and muscle fibrosis (MF). While, reflectory trismus was proposed before as an auxiliary mechanism by another group; the stretch mediated muscle damage (MSD), histopathological changes in blood vessels (like endothelial dysfunction, endothelial hypertrophy and endarteritis obliterans) and upregulated anaerobic isoforms of lactate dehydrogenase (LDH), have been proposed by us as complementary events leading to MF...
October 15, 2016: Journal of Oral Pathology & Medicine
M Lungova, M Krutyeva, W Pyckhout-Hintzen, A Wischnewski, M Monkenbusch, J Allgaier, M Ohl, M Sharp, D Richter
We have studied the motion of polyhedral oligomeric silsesquioxane (POSS) nanoparticles modified with poly(ethylene glycol) (PEG) arms immersed in PEG matrices of different molecular weight. Employing neutron spin echo spectroscopy in combination with pulsed field gradient (PFG) NMR we found the following. (i) For entangled matrices the center of mass mean square displacement (MSD) of the PEG-POSS particles is subdiffusive following a t^{0.56} power law. (ii) The diffusion coefficient as well as the crossover to Fickian diffusion is independent of the matrix molecular weight and takes place as soon as the center of mass has moved a distance corresponding to the particle radius-this holds also for unentangled hosts...
September 30, 2016: Physical Review Letters
Ken Nash, Frank Ghinassi, Jaspreet S Brar, Abdulkader Alam, Mary Catherine Bohan, Kalyani Gopalan, Amie Carter, K N Roy Chengappa
OBJECTIVES: 1. A quality performance improvement (QI) project to implement an electronic screening and monitoring tool to record components of the metabolic syndrome (e-MSD) during clinic visits by persons with serious mental illness (SMI). 2. To encourage psychiatrists to use this tool in their documentation. METHODS: Working with the information technology staff, five psychiatrists developed, tested, revised and embedded the e-MSD tool into the medication management document within the electronic health record...
2016: Clinical Schizophrenia & related Psychoses
Hong-Hua Li, Fei Li, Chun-Ji Gao, Wen-Rong Huang, Jian Bo, Li-Ping Dou, Li-Li Wang, Yu Jing, Lu Wang, Wen-Jun Li, Li Yu, Dai-Hong Liu
The features of graft-versus-host disease (GVHD) were compared between patients who underwent myeloablative conditioning and received a peripheral blood stem cell transplant (PBSCT) from either a haploidentical donor (HID) or a matched sibling donor (MSD) during the same period of time. The HID group included more patients with advanced disease. Both groups received the same GVHD prophylaxis with the addition of antithymoglobulin (ATG) in HID group. Higher cumulative incidences (CI) of acute GVHD grade 2-4 (35·1% vs...
October 7, 2016: British Journal of Haematology
Roopa Gaonkar, S Yallappa, B L Dhananjaya, Gurumurthy Hegde
Citral is a widely used monoterpene aldehyde in aromatherapy, food and pesticide industries. A new validated reverse phase high performance liquid chromatography (RP - HPLC) procedure for the detection and quantification of cis-trans isomers of citral was developed. The RP-HPLC analysis was carried out using Enable C - 18G column (250×4.6mm, 5μ), with acetonitrile and water (70: 30) mobile phase in isocratic mode at 1mL/min flow. A photodiode array (PDA) detector was set at 233nm for the detection of citral...
October 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
F Belva, M Bonduelle, M Roelants, D Michielsen, A Van Steirteghem, G Verheyen, H Tournaye
STUDY QUESTION: What is the semen quality of young adult men who were conceived 18-22 years ago by ICSI for male infertility? SUMMARY ANSWER: In this cohort of 54 young adult ICSI men, median sperm concentration, total sperm count and total motile sperm count were significantly lower than in spontaneously conceived peers. WHAT IS KNOWN ALREADY: The oldest ICSI offspring cohort worldwide has recently reached adulthood. Hence, their reproductive health can now be investigated...
October 5, 2016: Human Reproduction
Qingmin Feng, Shenglin Liu, Lei Yang, Mingxing Xie, Qiang Zhang
OBJECTIVE: Studies from industrialized countries show that musculoskeletal disorders (MSD) occur commonly in sonographers. However, little is known about sonographers in China, where the awareness of ergonomics and MSD, workload, and available equipment/facilities may differ. We aimed to investigate the prevalence of MSD and associated risk factors in sonographers in central China. METHODS: A cross-sectional survey was conducted with 381 sonographers from 14 randomly selected tertiary hospitals in Hubei province, central China...
2016: PloS One
Nodooshan H Salmani, S H Koohi, H Daneshmandi, A R Choobineh
BACKGROUND: In Iranian orthotic and prosthetic workshops, the majority of activities are carried out by manpower and the tasks are labor-intensive. In these workshops, ergonomic aspects of working conditions are seldom considered. OBJECTIVE: This study was conducted in orthotic and prosthetic workshops with the objectives of determination of prevalence rate of MSDs among employees and assessment of ergonomics working conditions. METHODS: In this cross-sectional study, all employees (n = 42; 29 males and 13 females) in 11 active orthotic and prosthetic production centers of Shiraz city participated...
September 27, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
Sana Salah, Mariem Rekik, Iheb Bel Haj Youssef, Soumaya Boudokhane, Houda Migaou, Anis Jellad, Zohra Ben Salah Frih
OBJECTIVE: The objective of this study was to assess the musculoskeletal disorders (MSD) of diabetes mellitus (DM) patients in a Physical Medicine and Rehabilitation (PMR) department. MATERIAL/PATIENTS AND METHODS: We carried out a retrospective study (January-December 2013) in which we enrolled 193 patients with DM. General (epidemic and clinical) characteristics were measured. Statistical analysis was performed using the statistical software SPSS 16. RESULTS: The participants' median age was 58 years (20-86), 98 men (50...
September 2016: Annals of Physical and Rehabilitation Medicine
Haifa Aroui, Irtyah Merchaoui, Mohamed Adnène Henchi, Ines Rassas, Noura Belhadj, Neila Chaari, Charfeddine Amri
OBJECTIVE: To determine the population attributable fraction (AF) related to occupational exposure to repetitive movements, in the genesis of musculoskeletal disorders (MSD) of the hand and wrist. MATERIAL/PATIENTS AND METHODS: Cohort study of 602 people divided into two groups (exposed to repetitive movements, unexposed group), matched for age, gender, job tenure and work schedules. The study had two components: a clinical study of the MSD of hands and wrists, and a study of workstations...
September 2016: Annals of Physical and Rehabilitation Medicine
Wei Deng, Yan Xu, Wenchun Chen, David S Paul, Anum K Syed, Matthew A Dragovich, Xin Liang, Philip Zakas, Michael C Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B Doering, Wolfgang Bergmeier, X Frank Zhang, Renhao Li
Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb-IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane 'Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance...
2016: Nature Communications
Tzahi Neuman, Michal London, Juliane Kania-Almog, Anna Litvin, Yaniv Zohar, Ludmila Fridel, Judith Sandbank, Iris Barshak, Gilad W Vainer
INTRODUCTION: Immunotherapy is a novel treatment for lung cancer. Pembrolizumab (Merck Sharp and Dohme, Kenilworth, NJ) is a monoclonal antibody against programmed cell death 1 that has been approved for use with NSCLC together with a companion diagnostic by Dako (Carpinteria, CA). Ventana's BenchMark XT (Ventana Medical Systems, Tucson, AZ) is a widely used immunohistochemical (IHC) platform. However, data on its reliability and reproducibility with the 22C3 antibody are scant. METHODS: We performed a comprehensive calibration of 22C3 programmed cell death ligand 1 (PD-L1) staining on the BenchMark XT platform using Dako's prediluted 22C3 anti-PD-L1 primary antibody with two of Ventana's detection systems...
September 21, 2016: Journal of Thoracic Oncology
Helena Hognert, Helena Kopp Kallner, Sharon Cameron, Christina Nyrelli, Izabella Jawad, Rebecca Heller, Annette Aronsson, Ingela Lindh, Lina Benson, Kristina Gemzell-Danielsson
STUDY QUESTION: Does a progestin releasing subdermal contraceptive implant affect the efficacy of medical abortion if inserted at the same visit as the progesterone receptor modulator, mifepristone, at medical abortion? SUMMARY ANSWER: A etonogestrel releasing subdermal implant inserted on the day of mifepristone did not impair the efficacy of the medical abortion compared with routine insertion at 2-4 weeks after the abortion. WHAT IS ALREADY KNOWN: The etonogestrel releasing subdermal implant is one of the most effective long acting reversible contraceptive methods...
September 22, 2016: Human Reproduction
Xiaodan Zhu, Chunhong Jia, Lifang Duan, Wei Zhang, Pingzhong Yu, Min He, Li Chen, Ercheng Zhao
The residue behavior and dietary intake risk of three fungicides (pyrimethanil, iprodione, kresoxim-methyl) in tomatoes (Lycopersicon esculentum Mill.) grown in greenhouse were investigated. A simple, rapid analytical method for the quantification of fungicide residues in tomatoes was developed using gas chromatography coupled with mass spectrum detection (GC-MSD). The fortified recoveries were ranged from 87% to 103% with relative standard deviations (RSDs) varied from 4.7% to 12.1%. The results indicated that the dissipation rate of the studied fungicides in tomatoes followed first order kinetics with half lives in the range of 8...
September 17, 2016: Regulatory Toxicology and Pharmacology: RTP
Fei Gao, Huibin Jia, Xiangci Wu, Dongchuan Yu, Yi Feng
The aim of this study was to investigate the resting-state EEG microstate parameters and spatial complexity in male adolescent patients with mild spastic diplegia (MSD). Resting-state EEG data were collected from male adolescent patients with MSD and healthy controls with eyes closed. EEG microstate and omega complexity analysis were performed. Microstate analysis revealed that the occurrence rate of microstate class A and D were significantly higher and the duration of microstate class B was significantly lower in the patients compared to healthy controls, which indicated that the temporal complexity may be higher and certain cognitive functions may be impaired in these patients...
September 17, 2016: Brain Topography
Annalisa Ruggeri, Giorgia Battipaglia, Myriam Labopin, Gerhard Ehninger, Dietrich Beelen, Johanna Tischer, Arnold Ganser, Rainer Schwerdtfeger, Bertram Glass, Jurgen Finke, Mauricette Michallet, Matthias Stelljes, Pavel Jindra, Renate Arnold, Nicolaus Kröger, Mohamad Mohty, Arnon Nagler
BACKGROUND: Allogeneic stem cell transplantation is the only curative option for patients with acute myeloid leukemia (AML) experiencing relapse. Either matched sibling donor (MSD) or unrelated donor (UD) is indicated. METHODS: We analyzed 1554 adults with AML transplanted from MSD (n = 961) or UD (n = 593, HLA-matched 10/10, n = 481; 9/10, n = 112). Compared to MSD, UD recipients were older (49 vs 52 years, p = 0.001), transplanted more recently (2009 vs 2006, p = 0...
September 17, 2016: Journal of Hematology & Oncology
L Zhou, L-Y Wang, X-M Zhang, N-L Zeng, T-W Chen, R Li, Y-C Huang, Y-L Tang
AIM: To determine whether liver lobe-based DCE-MRI can be used to detect the presence and Child-Pugh class of hepatitis B-related cirrhosis. MATERIALS AND METHODS: Fifty-six cirrhotic patients with hepatitis B and 20 healthy participants underwent liver DCE-MRI, and the positive enhancement integral (PEI), time to peak (TTP), maximum slope of increase (MSI) and maximum slope of decrease (MSD) of the left lateral liver lobe (LLL), left medial liver lobe (LML), right liver lobe (RL), and caudate lobe (CL) were measured and analysed statistically to evaluate cirrhosis...
September 12, 2016: Clinical Radiology
Emanuele Brianti, Ettore Napoli, Gabriella Gaglio, Luigi Falsone, Salvatore Giannetto, Fabrizio Solari Basano, Roberto Nazzari, Maria Stefania Latrofa, Giada Annoscia, Viviana Domenica Tarallo, Dorothee Stanneck, Filipe Dantas-Torres, Domenico Otranto
This study investigated the efficacy of two collars for the treatment and prevention of flea infestations. Additionally the effect of these collars on the incidence of Leishmania infantum infection as compared with a group of vaccinated dogs was evaluated. A total of 224 young dogs from private animal shelters were enrolled in April/May into four groups: G1, 55 dogs treated with 10% imidacloprid + 4.5% flumethrin collar (Seresto, Bayer Animal Health); G2, 60 dogs treated with 4% deltamethrin collar (Scalibor protector band, MSD Animal Health); G3, 54 dogs vaccinated with CaniLeish (Virbac Animal Health); and G4, 55 dogs left non-treated as controls...
September 2016: PLoS Neglected Tropical Diseases
Zdzisław A Bogucki, Mariola Kownacka
The purpose of this work is to present a new, still experimental method of treating temporomandibular disorders (TMD) by injecting botulinum toxin Type A (TBX-A), using its effects not as a toxin but as a medication. The mechanism of TBX-A, indications and contraindications for its use, as well as possible side effects, are discussed. Temporomandibular disorders are of concern to approximately 70-80% of the population. The effect of botulinum toxin depends on blocking the release of acetylcholine from a presynaptic neuromuscular synapse and, in the autonomous system, blocking its release from post-ganglionic cholinergic neurons...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mamoru Kato, Koichi Chida, Takashi Moritake, Tadaya Sato, Hajime Oosaka, Hideto Toyoshima, Masayuki Zuguchi, Yoshihisa Abe
The purpose of this research was to measure accurate patient entrance skin dose and maximum skin absorbed dose (MSD) to prevent radiation skin injuries in percutaneous coronary interventions (PCIs). We directly measured the MSD on 50 PCIs by using multiple radiophotoluminescence glass dosimeters and a modified dosimetry gown. Also, we analysed the correlation between the MSD and indirect measurement parameters, such as fluoroscopic time (FT), dose-area product (DAP) and cumulative air kerma (C-AK). There were very strong correlations between MSD and FT, DAP and C-AK, with the correlation between MSD and C-AK being the strongest (r = 0...
September 13, 2016: Radiation Protection Dosimetry
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