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https://www.readbyqxmd.com/read/28633449/night-work-as-a-risk-factor-of-future-disability-pension-due-to-musculoskeletal-diagnoses-a-prospective-cohort-study-of-swedish-twins
#1
Sanna Kärkkäinen, Annina Ropponen, Jurgita Narusyte, Lisa Mather, Torbjörn Åkerstedt, Karri Silventoinen, Ellenor Mittendorfer-Rutz, Pia Svedberg
Background: This study investigated the associations between night work, sleep and disability pension (DP) due to musculoskeletal disorders (MSD), while controlling for several confounding factors including both genetic factors and shared family background. Methods: The study sample consisted of 27 165 Swedish twin individuals born in 1935-58 with comprehensive survey data on sociodemographic, health and lifestyle factors. Night work was assessed as years of working hours at night at least every now and then, and categorized into 'not at all, 1-10 years and over 10 years'...
June 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28617528/influence-of-ablation-therapy-on-the-quality-of-life-in-children-with-supraventricular-tachycardia
#2
E Szafran, A Baszko, A Bukowska-Posadzy, A Łaźniak, T Moszura, A Siwińska, J Walkowiak, W Bobkowski
OBJECTIVE: Numerous restrictions, which are imposed on children with arrhythmia, influence their quality of life (QoL) and may have a negative impact on their further development. Ablation is a highly successful treatment leaving patients free from arrhythmia and other related limitations. There are very few studies evaluating the influence of ablation on the QoL in children with arrhythmia, based on small groups of patients. The aim of this study was to evaluate the impact of ablation on the QoL in children with supraventricular tachycardia (SVT)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28610569/a-novel-tamponade-agent-for-management-of-post-partum-hemorrhage-adaptation-of-the-xstat-mini-sponge-applicator-for-obstetric-use
#3
Maria I Rodriguez, Jeffrey T Jensen, Kenton Gregory, Mary Bullard, Paul Longo, Jerry Heidel, Alison Edelman
BACKGROUND: Although uterine tamponade is an effective treatment for postpartum hemorrhage (PPH), current methods have key limitations in their use, particularly in low resource settings. The XStat™ Mini Sponge Dressing (MSD) is approved for the management of non-compressible wounds in the battlefield/trauma setting. The MSD applies highly compressed medical sponges capable of stopping high-flow arterial bleeding within seconds. The objective of our study was to adopt the MSD for use in managing PPH...
June 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28605693/evaluation-of-flunixin-meglumine-pour-on-administration-on-prostaglandin-e2-concentration-in-inflammatory-exudate-after-induction-of-inflammation-in-cattle
#4
Julien Thiry, René Fournier, Olivier Roy, Mathias Catala
The effect of flunixin transdermal pour-on solution (Finadyne® Transdermal; MSD Animal Health) on prostaglandin E2 (PGE2) synthesis in bovine inflammatory exudate was evaluated in a tissue cage model of acute inflammation. Twelve calves were randomly allocated to two-treatment groups over two sequences. Three weeks prior to the first period, sterile hollow perforated polyethylene balls were surgically embedded in the subcutis at four distinct sites in each animal. On the first day of each period, an aseptic inflammation was induced by injecting 0...
April 20, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28597921/feasibility-of-canine-detection-of-mass-storage-devices-a-study-of-volatile-organic-compounds-emanating-from-electronic-devices-using-solid-phase-microextraction
#5
Lauryn E DeGreeff, Michelle Cerreta, Mark Rispoli
Detection of canines are well-known to be valuable in the location of contraband, such as explosives or narcotics. More recently, canines have been trained and utilized in the detection of concealed mass storage devices that might contain evidence of illegal activity such as child pornography. To lay the analytical foundation for this detection work, research was carried out to determine the volatile organic compounds associated with mass storage devices (MSD) that could be used by trained canines for detection...
June 9, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28597314/deltamethrin-as-inductor-agent-of-precocious-ovarian-degeneration-in-rhipicephalus-sanguineus-s-l-acari-ixodidae-ticks
#6
Maria Izabel Camargo-Mathias, Natalia Rubio Claret Pereira, Camila da Silva Reis, Cristiane Regina de Almeida, Douglas Rodrigo Dos Santos Mendes, Giselle Bezerra de Araújo, Lays Postali, Tober Figueroa, Allan Roberto Fernandes Ferreira, Juan Parente Santos, Patrícia Rosa de Oliveira
The cosmopolitan species Rhipicephalus sanguineus s.l. is one of the most widely distributed ticks all over the world. These ectoparasites are vectors of several pathogens and cause significant direct damage to their hosts. The biological success of these ectoparasites has been attributed to their ovaries and salivary glands, organs that ensure their survival in various environmental conditions. The importance of the ovaries in ticks is that, after mating, the individuals are able to lay approximately three thousand eggs...
June 8, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28592329/autoimmune-antibody-decline-in-parkinson-s-disease-and-multiple-system-atrophy-a-step-towards-immunotherapeutic-strategies
#7
Tomasz Brudek, Kristian Winge, Jonas Folke, Søren Christensen, Karina Fog, Bente Pakkenberg, Lars Østergaard Pedersen
BACKGROUND: Parkinson's' disease (PD) and Multiple System Atrophy (MSA) are progressive brain disorders characterized by intracellular accumulations of α-synuclein and nerve cell loss in specific brain areas. This loss causes problems with movement, balance and/or autonomic functions. Naturally occurring autoantibodies (NAbs) play potentially an important role in clearing or/and blocking circulating pathological proteins. Little is known about the functional properties of anti-α-synuclein NAbs in PD and MSA, and there have been opposing reports regarding their plasma concentrations in these disorders...
June 7, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28589493/a-randomized-placebo-controlled-trial-evaluating-the-safety-and-efficacy-of-adding-omarigliptin-to-antihyperglycemic-therapies-in-japanese-patients-with-type-2-diabetes-and-inadequate-glycemic-control
#8
Ira Gantz, Taro Okamoto, Yuka Ito, Asako Sato, Kotoba Okuyama, Edward A O'Neill, Samuel S Engel, Eseng Lai
INTRODUCTION: Daily dipeptidyl peptidase-4 (DPP-4) inhibitors are commonly used with other orally administered antihyperglycemic agents (AHA), as combination therapy, to treat Japanese patients with type 2 diabetes. When combination therapy is indicated, use of a once-weekly (q.w.) orally administered DPP-4 inhibitor might be an appropriate therapeutic option for some patients. METHODS: A 52-week trial was conducted to assess the safety and tolerability (primary objectives) and glycemic efficacy (secondary objectives) of the q...
June 6, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28585925/conserved-linear-dynamics-of-single-molecule-brownian-motion
#9
Maged F Serag, Satoshi Habuchi
Macromolecular diffusion in homogeneous fluid at length scales greater than the size of the molecule is regarded as a random process. The mean-squared displacement (MSD) of molecules in this regime increases linearly with time. Here we show that non-random motion of DNA molecules in this regime that is undetectable by the MSD analysis can be quantified by characterizing the molecular motion relative to a latticed frame of reference. Our lattice occupancy analysis reveals unexpected sub-modes of motion of DNA that deviate from expected random motion in the linear, diffusive regime...
June 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28583093/physical-working-conditions-as-covered-in-european-monitoring-questionnaires
#10
Tore Tynes, Cecilie Aagestad, Sannie Vester Thorsen, Lars Louis Andersen, Merja Perkio-Makela, Francisco Javier Pinilla García, Luz Galiana Blanco, Greet Vermeylen, Agnes Parent-Thirion, Wendela Hooftman, Irene Houtman, Falk Liebers, Hermann Burr, Maren Formazin
BACKGROUND: The prevalence of workers with demanding physical working conditions in the European work force remains high, and occupational physical exposures are considered important risk factors for musculoskeletal disorders (MSD), a major burden for both workers and society. Exposures to physical workloads are therefore part of the European nationwide surveys to monitor working conditions and health. An interesting question is to what extent the same domains, dimensions and items referring to the physical workloads are covered in the surveys...
June 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28582951/the-effects-of-physical-and-psychosocial-factors-and-ergonomic-conditions-on-the-prevalence-of-musculoskeletal-disorders-among-dentists-in-malaysia
#11
Mohd Firdaus Mohd Taib, Sangwoo Bahn, Myung Hwan Yun, Mohd Syukri Mohd Taib
BACKGROUND: Musculoskeletal disorders (MSDs) have been recognized as one of the main occupational health problems for dentists. Many studies have suggested that dentists experience work-related pain or discomfort in the neck, shoulder, and back, as well as in other parts of the body. OBJECTIVE: This study aimed to examine the relationship between specific physical and psychosocial factors and/or ergonomic conditions on MSD symptoms among dentists in Malaysia. METHODS: A group of 85 dentists was asked to complete a questionnaire to determine whether their complaints were related to physical and psychosocial factors and/or ergonomic conditions in their practices...
June 1, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28579359/evolution-in-treatment-strategy-for-metastatic-spine-disease-presently-evolving-modalities
#12
REVIEW
N Kumar, R Malhotra, A S Zaw, K Maharajan, N Naresh, A Kumar, B Vellayappan
The advent of minimally invasive surgery (MIS) in the surgical management armamentarium and stereotactic radiosurgery in the domain of radiotherapy, has led to a major evolution in treatment of metastatic spine disease (MSD). We reviewed the recent literature to discuss evolution from open to MIS approaches in MSD and the concurrent evolution in radiotherapy. This will provide a sound base for further development and understanding of treatment paradigms in MSD. Literature review showed that evolution of surgery can be traced from inappropriate open surgery (i...
May 17, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28573884/content-and-psychometric-evaluations-of-questionnaires-for-assessing-physical-function-in-people-with-neck-disorders-a-systematic-review-of-the-literature
#13
Birgitta Wiitavaara, Marina Heiden
PURPOSE: The purpose was to investigate how physical function is assessed in people with musculoskeletal disorders (MSD) in the neck. Specifically, we aimed to determine: (1) Which questionnaires are used to assess physical function in people with MSD in the neck? (2) What do those questionnaires measure? (3) What are the measurement properties of the questionnaires? MATERIALS AND METHODS: A systematic review was performed to identify questionnaires and psychometric evaluations...
June 2, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28571369/network-confinement-and-heterogeneity-slows-nanoparticle-diffusion-in-polymer-gels
#14
Emmabeth Parrish, Matthew A Caporizzo, Russell J Composto
Nanoparticle (NP) diffusion was measured in polyacrylamide gels (PAGs) with a mesh size comparable to the NP size, 21 nm. The confinement ratio (CR), NP diameter/mesh size, increased from 0.4 to 3.8 by increasing crosslinker density and from 0.4 to 2.1 by adding acetone, which collapsed the PAGs. In all gels, NPs either became localized, moving less than 200 nm, diffused microns, or exhibited a combination of these behaviors, as measured by single particle tracking. Mean squared displacements (MSDs) of mobile NPs decreased as CR increased...
May 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28566233/expanding-the-genetic-cause-of-multiple-sulfatase-deficiency-a-novel-sumf1-variant-in-a-patient-displaying-a-severe-late-infantile-form-of-the-disease
#15
Ilona Jaszczuk, Lars Schlotawa, Thomas Dierks, Andreas Ohlenbusch, Dominique Koppenhöfer, Mariusz Babicz, Monika Lejman, Karthikeyan Radhakrishnan, Agnieszka Ługowska
Multiple sulfatase deficiency (MSD) is a rare inherited metabolic disease caused by defective cellular sulfatases. Activity of sulfatases depends on post-translational modification catalyzed by formylglycine-generating enzyme (FGE), encoded by the SUMF1 gene. SUMF1 pathologic variants cause MSD, a syndrome presenting with a complex phenotype. We describe the first Polish patient with MSD caused by a yet undescribed pathologic variant c.337G>A [p.Glu113Lys] (i.e. p.E113K) in heterozygous combination with the known deletion allele c...
May 22, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28558844/radiation-related-lymphopenia-is-associated-with-spleen-irradiation-dose-during-radiotherapy-in-patients-with-hepatocellular-carcinoma
#16
Jing Liu, Qianqian Zhao, Weiye Deng, Jie Lu, Xiaoqing Xu, Renben Wang, Xia Li, Jinbo Yue
BACKGROUND: The decrease in peripheral blood lymphocytes induced by radiation lessens the antitumour effect of the immune response, which might cause immunosuppression. We aimed to investigate the correlation between the decrease in peripheral blood lymphocytes during radiotherapy (RT) and the spleen irradiation dose in patients with hepatocellular carcinoma (HCC). METHODS: The subjects were 59 patients with HCC who had received RT from 2005 to 2014. The Min ALC (minimum value of absolute counts for peripheral blood lymphocytes) was collected from the routine workup for each patient prior to RT and weekly during RT...
May 30, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28554305/-then-they-trust-you%C3%A2-%C3%A2
#17
Marsha Love, Felipe Tendick-Matesanz, Jane Thomason, Davine Carter, Myra Glassman, Joseph Zanoni
The home care workforce, already at 2.7 million caregivers, will become the nation's fastest growing occupation by 2024 as the senior boom generation accelerates the demand for in home services to meet its long-term care needs. The physically challenging work of assisting clients with intimate, essential acts of daily living places home care workers (HCWs) at risk for musculoskeletal disorders (MSDs); yet, HCWs typically receive little formal job training and may lack appropriate assistive devices. In this qualitative pilot study, HCW focus groups described workplace MSD risk factors and identified problem-solving strategies to improve ergonomic conditions...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28552421/reduced-intensity-conditioning-with-busulfan-fludarabine-and-antithymocyte-globulin-for-hematopoietic-cell-transplantation-from-unrelated-or-haploidentical-family-donors-in-patients-with-acute-myeloid-leukemia-in-remission
#18
Kyoo-Hyung Lee, Je-Hwan Lee, Jung-Hee Lee, Dae-Young Kim, Han-Seung Park, Eun-Ji Choi, Sun-Hye Ko, Miee Seol, Young-Shin Lee, Young-A Kang, Mijin Jeon, Seunghyun Baek, You-Lee Kang, Sung-Han Kim, Sung-Cheol Yun, Hawk Kim, Jae-Cheol Jo, Yunsuk Choi, Young-Don Joo, Sung-Nam Lim
To investigate the role of antithymocyte globulin (ATG)-containing reduced-intensity conditioning (RIC) in hematopoietic cell transplantation (HCT) from unrelated (UD) or haploidentical family donors (HFD), we conducted a phase 2 trial of 237 patients (age range, 16 to 69 years) with acute myeloid leukemia (AML) in remission. Patients undergoing UD-HCT (n = 93) or HFD-HCT (n = 59) received RIC comprising busulfan, fludarabine, and ATG, 9 mg/kg, whereas those undergoing HCT from matched sibling donors (MSD, n = 85) received myeloablative busulfan and cyclophosphamide conditioning or aforementioned RIC with ATG, 4...
May 25, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28550420/associations-between-common-diseases-and-work-ability-and-sick-leave-among-health-care-workers
#19
Sophie van den Berg, Alex Burdorf, Suzan J W Robroek
PURPOSE: This study investigates whether common diseases, i.e., musculoskeletal diseases (MSD), cardiovascular diseases (CVD), mental disorders (MD), and respiratory diseases (RD), influence work ability and sick leave and whether lifestyle-related factors, and psychosocial and physical work-related factors are associated with low work ability and sick leave. METHODS: In a cross-sectional study among 8364 Dutch health care employees, self-reported information was acquired concerning common diseases, lifestyle-related factors, psychosocial and physical work-related factors, work ability, and sick leave...
May 26, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28546462/alternative-donor-graft-sources-for-adults-with-hematologic-malignancies-a-donor-for-all-patients-in-2017
#20
REVIEW
Tamila L Kindwall-Keller, Karen K Ballen
Hematopoietic stem cell transplant (HSCT) is potentially curative for a wide variety of malignant diseases, including acute and leukemias, lymphoma, and myelodysplasia. Choice of a stem cell donor is dependent on donor availability, donor compatibility and health, recipient disease type, and recipient condition. Current sources of stem cell donation for HSCT are matched sibling donors (MSDs), matched unrelated donors (MUDs), 1-antigen mismatched unrelated donors (MMUDs), haploidentical donors (haplo), and umbilical cord blood (UCB) units...
May 25, 2017: Oncologist
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