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https://www.readbyqxmd.com/read/28333318/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#1
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
STUDY QUESTION: Is oral dydrogesterone 30 mg daily (10 mg three times daily [TID]) non-inferior to micronized vaginal progesterone (MVP) 600 mg daily (200 mg TID) for luteal support in in vitro fertilization (IVF), assessed by the presence of fetal heartbeats determined by transvaginal ultrasound at 12 weeks of gestation? SUMMARY ANSWER: Non-inferiority of oral dydrogesterone versus MVP was demonstrated at 12 weeks of gestation, with a difference in pregnancy rate and an associated confidence interval (CI) that were both within the non-inferiority margin...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28327466/regional-deep-hyperthermia-impact-of-observer-variability-in-ct-based-manual-tissue-segmentation-on-a-simulated-temperature-distribution
#2
Bassim Aklan, Josefin Hartmann, Diana Zink, Hadi Siavooshhaghighi, Ricarda Merten, Florian Putz, Oliver Ott, Rainer Fietkau, Christoph Bert
The aim of this study was to systematically investigate the influence of inter- and intra-observer segmentation variation of tumor and organs at risk on the simulated temperature coverage of the target. CT scans of six patients with tumors in the pelvic region acquired for radiotherapy treatment planning were used for the hyperthermia treatment planning. To study the effect of inter-observer variation, three observers manually segmented in the CT images of each patient the following structures: fat, muscle, bone and bladder...
March 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28325585/gender-differences-in-demographic-and-clinical-correlates-among-veterans-with-musculoskeletal-disorders
#3
Diana M Higgins, Brenda T Fenton, Mary A Driscoll, Alicia A Heapy, Robert D Kerns, Matthew J Bair, Constance Carroll, Penny L Brennan, Diana J Burgess, John D Piette, Sally G Haskell, Cynthia A Brandt, Joseph L Goulet
BACKGROUND: Studies suggest that women may be at greater risk for developing chronic pain and pain-related disability. METHODS: Because musculoskeletal disorders (MSD) are the most frequently endorsed painful conditions among veterans, we sought to characterize gender differences in sociodemographic and clinical correlates among veterans upon entry into Veterans Health Administration's Musculoskeletal Disorders Cohort (n = 4,128,008). RESULTS: Women were more likely to be younger, Black, unmarried, and veterans of recent conflicts...
March 18, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28319267/risk-factors-associated-with-failure-of-treatment-for-cesarean-scar-pregnancy
#4
Ying-Cheng Chiang, Yi-An Tu, Jehn-Hsiahn Yang, Shin-Yu Lin, Chien-Nan Lee, Jin-Chung Shih
OBJECTIVE: To identify risk factors associated with treatment failure among women with cesarean scar pregnancy (CSP). METHODS: In a retrospective study, the medical records of patients with CSP treated at National Taiwan University Hospital, Taipei, Taiwan, from 1994 to 2015 were reviewed. The women were managed primarily with hysterotomy, evacuation, or methotrexate. Receiver operating characteristic (ROC) curve analysis and logistic regression analysis were used to evaluate the factors associated with treatment failure...
March 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28306646/prevalence-of-musculoskeletal-disorders-among-surgeons-performing-minimally-invasive-surgery-a-systematic-review
#5
Chantal C J Alleblas, Anne Marie de Man, Lukas van den Haak, Mark E Vierhout, Frank Willem Jansen, Theodoor E Nieboer
OBJECTIVE: The aim of this study was to review musculoskeletal disorder (MSD) prevalence among surgeons performing minimally invasive surgery. BACKGROUND: Advancements in laparoscopic surgery have primarily focused on enhancing patient benefits. However, compared with open surgery, laparoscopic surgery imposes greater ergonomic constraints on surgeons. Recent reports indicate a 73% to 88% prevalence of physical complaints among laparoscopic surgeons, which is greater than in the general working population, supporting the need to address the surgeons' physical health...
March 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28299449/contribution-of-job-exposure-matrices-for-exposure-assessment-in-occupational-safety-and-health-monitoring-systems-application-from-the-french-national-occupational-disease-surveillance-and-prevention-network
#6
Arnaud Florentin, Denis Zmirou-Navier, Christophe Paris
OBJECTIVES: To detect new hazards ("signals"), occupational health monitoring systems mostly rest on the description of exposures in the jobs held and on reports by medical doctors; these are subject to declarative bias. Our study aims to assess whether job-exposure matrices (JEMs) could be useful tools for signal detection by improving exposure reporting. METHODS: Using the French national occupational disease surveillance and prevention network (RNV3P) data from 2001 to 2011, we explored the associations between disease and exposure prevalence for 3 well-known pathology/exposure couples and for one debatable couple...
March 16, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28297926/aging-ballistic-l%C3%A3-vy-walks
#7
Marcin Magdziarz, Tomasz Zorawik
Aging can be observed for numerous physical systems. In such systems statistical properties [like probability distribution, mean square displacement (MSD), first-passage time] depend on a time span t_{a} between the initialization and the beginning of observations. In this paper we study aging properties of ballistic Lévy walks and two closely related jump models: wait-first and jump-first. We calculate explicitly their probability distributions and MSDs. It turns out that despite similarities these models react very differently to the delay t_{a}...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297292/a-comprehensive-evaluation-of-adaptive-daily-planning-for-cervical-cancer-hdr-brachytherapy
#8
Rebecca Meerschaert, Adrian Nalichowski, Jay Burmeister, Arun Paul, Steven Miller, Zhenghui Hu, Ling Zhuang
The purpose of this study was to evaluate adaptive daily planning for cervical cancer patients who underwent high-dose-rate intracavitary brachytherapy (HDR-BT) using comprehensive interfractional organ motion measurements. This study included 22 cervical cancer patients who underwent 5 fractions of HDR-BT. Regions of interest (ROIs) including high-risk clinical tumor volume (HR-CTV) and organs at risk (OARs) were manually contoured on daily CT images. All patients were clinically treated with adaptive daily plans (ADP), which involved ROI delineation and dose optimization at each treatment fraction...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28290948/mortality-surveillance-for-infectious-diseases-in-the-u-s-department-of-defense-1998-2013
#9
Robert N Potter, Ladd A Tremaine, Joel C Gaydos
INTRODUCTION: The Mortality Surveillance Division (MSD) of the U.S. Armed Forces Medical Examiner System was established in 1998 to improve surveillance for all military deaths although emphasizing deaths from infectious diseases. Establishment of the MSD was part of the 1997 Department of Defense initiative to improve surveillance and response for emerging infectious diseases. Before 1998, mortality surveillance was limited to compiling information from death certificates, a system that provided limited useful information and lacked the timeliness needed to take meaningful action to address emerging infectious disease threats...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28289957/molecular-dynamics-simulation-of-effect-of-glycerol-monostearate-on-amorphous-polyethylene-in-the-presence-of-water
#10
Shinya Iwata
Polyethylene (PE) is used widely as an electrical insulating material. However, the deterioration of its insulating ability is accelerated by exposure to a humid environment. To prevent the influence of water molecules, mixing 2,3-dihydroxypropyl octadecanoate-known as glycerol monostearate (GMS)-into PE has been proposed. However, the physical mechanism underlying the effect of GMS remains unclear. In the present study, the behavior of water molecules in amorphous PE with and without GMS molecule(s) was investigated in terms of diffusion and clustering using molecular dynamics (MD) simulations...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28279161/methylated-site-display-msd-aflp-a-sensitive-and-affordable-method-for-analysis-of-cpg-methylation-profiles
#11
Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, Harunobu Yunokawa, Toru Maruyama, Wataru Fujibuchi, Hisaka Kurita, Chiharu Tohyama, Seiichiroh Ohsako
BACKGROUND: It has been pointed out that environmental factors or chemicals can cause diseases that are developmental in origin. To detect abnormal epigenetic alterations in DNA methylation, convenient and cost-effective methods are required for such research, in which multiple samples are processed simultaneously. We here present methylated site display (MSD), a unique technique for the preparation of DNA libraries. By combining it with amplified fragment length polymorphism (AFLP) analysis, we developed a new method, MSD-AFLP...
March 9, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28266613/screening-with-an-nmnat2-msd-platform-identifies-small-molecules-that-modulate-nmnat2-levels-in-cortical-neurons
#12
Yousuf O Ali, Gillian Bradley, Hui-Chen Lu
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a key neuronal maintenance factor and provides potent neuroprotection in numerous preclinical models of neurological disorders. NMNAT2 is significantly reduced in Alzheimer's, Huntington's, Parkinson's diseases. Here we developed a Meso Scale Discovery (MSD)-based screening platform to quantify endogenous NMNAT2 in cortical neurons. The high sensitivity and large dynamic range of this NMNAT2-MSD platform allowed us to screen the Sigma LOPAC library consisting of 1280 compounds...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265296/fit-to-play-posture-and-seating-position-analysis-with-professional-musicians-a-study-protocol
#13
Daniela Ohlendorf, Eileen M Wanke, Natalie Filmann, David A Groneberg, Alexander Gerber
BACKGROUND: Musical performance-associated musculoskeletal disorders (MSD) are a common health problem among professional musicians. Considering the manifold consequences arising for the musicians, they can be seen as a threat for their professional activity. String players are the most affected group of musicians in this matter. Faults in upper body posture while playing the instrument, causing un-ergonomic static strain on the back and unergonomic limp-movements, are a main reason for musculoskeletal disorders and pain syndromes...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28247253/study-of-structural-and-transport-properties-of-argon-krypton-and-their-binary-mixtures-at-different-temperatures
#14
Sunil Ghimire, Narayan Prasad Adhikari
Molecular dynamics simulation of argon, krypton, and their binary mixtures were performed at different temperatures and constant pressure (P = 1.013 bar) using GROMACS - Groningen Machine for Chemical Simulations. The gases are modeled by Lennard-Jones pair potential, with parameters taken from the literature. The study of radial distribution functions (RDFs) shows a single peak which indicates that there is no packing effect in gaseous state for argon, krypton, and their binary mixtures. The self-diffusion coefficients of argon and krypton is determined by using mean-square displacement(MSD) method and the mutual diffusion coefficients of binary mixtures are determined using Darken's relation...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28242574/an-improved-size-exclusion-hplc-method-for-molecular-size-distribution-analysis-of-immunoglobulin-g-using-sodium-perchlorate-in-the-eluent
#15
Hsiaoling Wang, Mark S Levi, Alfred V Del Grosso, William M McCormick, Lokesh Bhattacharyya
Size exclusion (SE) high performance liquid chromatography (HPLC) is widely used for the molecular size distribution (MSD) analyses of various therapeutic proteins. We report development and validation of a SE-HPLC method for MSD analyses of immunoglobulin G (IgG) in products using a TSKgel SuperSW3000 column and eluting it with 0.4M NaClO4, a chaotropic salt, in 40mM phosphate buffer, pH 6.8. The chromatograms show distinct peaks of aggregates, tetramer, and two dimers, as well as the monomer and fragment peaks...
February 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28217089/differential-modulation-of-rhythmic-brain-activity-in-healthy-adults-by-a-t-type-calcium-channel-blocker-an-meg-study
#16
Kerry D Walton, Emeline L Maillet, John Garcia, Timothy Cardozo, Isaac Galatzer-Levy, Rodolfo R Llinás
1-octanol is a therapeutic candidate for disorders involving the abnormal activation of the T-type calcium current since it blocks this current specifically. Such disorders include essential tremor and a group of neurological and psychiatric disorders resulting from thalamocortical dysrhythmia (TCD). For example, clinically, the observable phenotype in essential tremor is the tremor itself. The differential diagnostic of TCD is not based only on clinical signs and symptoms. Rather, TCD incorporates an electromagnetic biomarker, the presence of abnormal thalamocortical low frequency brain oscillations...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28216279/outcomes-and-drug-costs-of-sunitinib-regimens-for-metastatic-renal-cell-carcinoma-a-provincial-population-based-study
#17
Aleksi Suo, Urooj Iqbal, June Lim, Chel Lee, Kathy Gesy, Nayyer Iqbal, Tahir Abbas
BACKGROUND: Conventional sunitinib dosing in metastatic renal cell carcinoma (mRCC) administers 50 mg daily on a 4 weeks on/2 weeks off (4/2) schedule. Not all patients tolerate this regimen and many undergo modifications to schedule, dose, or both. MATERIAL AND METHODS: All patients with mRCC treated with sunitinib by the Saskatchewan Cancer Agency between January 1, 2006, and January 1, 2013, were included. Regimens were categorized as standard intermittent dosing (SID), modified intermittent schedule (MIS), modified intermittent dosing (MID), combination of modified schedule and dosing (MSD), or continuous dosing (CD)...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28215676/impact-of-phase-of-the-estrous-cycle-and-season-on-lh-surge-profile-and-fertility-in-dairy-cows-treated-with-different-gnrh-analogs-gonadorelin-vs-buserelin
#18
R Armengol-Gelonch, J M Mallo, D Ponté, A Jimenez, A Valenza, A H Souza
Our aim was to assess the GnRH-induced LH surge profile in dairy cows receiving two GnRH products (gonadorelin vs buserelin) given at proestrus or diestrus phase and to investigate whether season could alter LH surge profile in dairy cows. In Experiment 1, dairy cows at 108.2 ± 2.3 DIM, producing 41.5 ± 0.3 kg/day were randomized to receive, during proestrus and diestrus: Ovarelin(®) i.m. (OVA; n = 56; 100 mg of gonadorelin diacetate tetrahydrate; Ceva Animal Health, France) or Receptal(®) i.m. (REC; n = 52; 10 mcg of buserelin diacetate; MSD, Germany)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28210839/thrombotic-microangiopathy-caused-by-methionine-synthase-deficiency-diagnosis-and-treatment-pitfalls
#19
Maria Helena Vaisbich, Andressa Braga, Maria Gabrielle, Clarissa Bueno, Flávia Piazzon, Fernando Kok
BACKGROUND: Inborn errors of cobalamin (Cbl) metabolism form a large group of rare diseases. One of these, Cbl deficiency type C (CblC), is a well-known cause of thrombotic microangiopathy (TMA), especially in infants. However, there has only been a single published case of TMA associated to Cbl deficiency type G (CblG), also known as methionine synthase deficiency (MSD). CASE DIAGNOSIS/TREATMENT: A 21-month-old boy presented with pallor and oral ulcers during episodes of upper respiratory infection (URI)...
February 16, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28208482/aging-underdamped-scaled-brownian-motion-ensemble-and-time-averaged-particle-displacements-nonergodicity-and-the-failure-of-the-overdamping-approximation
#20
Hadiseh Safdari, Andrey G Cherstvy, Aleksei V Chechkin, Anna Bodrova, Ralf Metzler
We investigate both analytically and by computer simulations the ensemble- and time-averaged, nonergodic, and aging properties of massive particles diffusing in a medium with a time dependent diffusivity. We call this stochastic diffusion process the (aging) underdamped scaled Brownian motion (UDSBM). We demonstrate how the mean squared displacement (MSD) and the time-averaged MSD of UDSBM are affected by the inertial term in the Langevin equation, both at short, intermediate, and even long diffusion times...
January 2017: Physical Review. E
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