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https://www.readbyqxmd.com/read/28434530/accelerated-cellular-senescence-as-underlying-mechanism-for-functionally-impaired-bone-marrow-derived-progenitor-cells-in-ischemic-heart-disease
#1
Evelien Nollet, Vicky Y Hoymans, Inez R Rodrigus, Dina De Bock, Marc Dom, Viviane O M Van Hoof, Christiaan J Vrints, Emeline M Van Craenenbroeck
BACKGROUND AND AIMS: Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy. In search for underlying mechanisms for this BM dysfunction, accelerated cellular senescence was explored. METHODS: We analysed telomere length of BM-derived mononuclear cells (MNC) by MMqPCR in patients with coronary artery disease (n = 12), ischemic heart failure (HF; n = 9), non-ischemic HF (n = 7) and controls (n = 10), and related it to their myeloid differentiation capacity...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28421319/inferior-vena-cava-segmentation-with-parameter-propagation-and-graph-cut
#2
Zixu Yan, Feng Chen, Fa Wu, Dexing Kong
PURPOSE: The inferior vena cava (IVC) is one of the vital veins inside the human body. Accurate segmentation of the IVC from contrast-enhanced CT images is of great importance. This extraction not only helps the physician understand its quantitative features such as blood flow and volume, but also it is helpful during the hepatic preoperative planning. However, manual delineation of the IVC is time-consuming and poorly reproducible. METHODS: In this paper, we propose a novel method to segment the IVC with minimal user interaction...
April 18, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28418219/alpha-2-macroglobulin-as-a-region-specific-secretory-protein-in-male-reproductive-tract-and-its-dynamics-during-sperm-transit-towards-the-female-spermatheca-in-the-blue-crab
#3
Thanyaporn Senarai, Rapeepun Vanichviriyakit, Shinji Miyata, Chihiro Sato, Prapee Sretarugsa, Wattana Weerachatyanukul, Ken Kitajima
A 250-kDa protein was isolated from fluid in the middle spermatic duct (MSD) of the blue crab (Portunus pelagicus). N-terminal and partial amino acid sequences revealed that this MSD-specific protein is high similar to the plasma-enriched protein Alpha-2 macroglobulin (α2M). The P. pelagicus ortholog (Ppα2M) is a large glycoprotein possessing mannose and N-acetylglucosamine chains. Ppa2m mRNA was detected in the spermatic duct, androgenic gland, and hematopoietic tissue, whereas the protein was primarily observed in the apical cytoplasm of MSD epithelium and in the matrix of the acrosome of MSD sperm; however, distally within spermatic duct, Ppα2M was lost from the sperm membrane but remained in the sperm acrosome...
April 18, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28411738/implementing-powered-stretcher-and-load-systems-was-a-cost-effective-intervention-to-reduce-the-incidence-rates-of-stretcher-related-injuries-in-a-paramedic-service
#4
Daniel P Armstrong, Richard Ferron, Cindi Taylor, Brent McLeod, Steve Fletcher, Renée S MacPhee, Steven L Fischer
Paramedic services are considering moving towards the use of powered stretcher and load systems to reduce stretcher related injuries, but cost is perceived as a barrier. This study compared injury incidence rates, days lost, and compensation costs between Niagara Emergency Medical Service (NEMS) and Hamilton Paramedic Service (HPS) pre- (four years) and post- (one year) implementation of powered stretcher and load systems in NEMS. Prior to the intervention stretcher related musculoskeletal disorder (MSD) incidence rates averaged 20...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28411097/-acute-liver-failure-related-to-inherited-metabolic-diseases-in-young-children
#5
Filipa Dias Costa, Rita Moinho, Sandra Ferreira, Paula Garcia, Luísa Diogo, Isabel Gonçalves, Carla Pinto
INTRODUCTION: Pediatric acute liver failure (ALF) due to inherited metabolic diseases (IMD) is a rare life-threatening condition with a poor prognosis. Early intervention may be lifesaving. OBJECTIVE: To describe clinical presentation, investigation and outcomes of ALF related to IMD in young children. MATERIAL AND METHODS: Retrospective review of the medical records of children aged up to 24 months, admitted to a tertiary pediatric and neonatal Intensive Care Unit during a 27-year period, fulfilling the ALF criteria, with documented metabolic etiology...
April 11, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28396634/morphological-properties-of-mass-spring-networks-for-optimal-locomotion-learning
#6
Gabriel Urbain, Jonas Degrave, Benonie Carette, Joni Dambre, Francis Wyffels
Robots have proven very useful in automating industrial processes. Their rigid components and powerful actuators, however, render them unsafe or unfit to work in normal human environments such as schools or hospitals. Robots made of compliant, softer materials may offer a valid alternative. Yet, the dynamics of these compliant robots are much more complicated compared to normal rigid robots of which all components can be accurately controlled. It is often claimed that, by using the concept of morphological computation, the dynamical complexity can become a strength...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28391807/automatic-liver-segmentation-from-abdominal-ct-volumes-using-graph-cuts-and-border-marching
#7
Miao Liao, Yu-Qian Zhao, Xi-Yao Liu, Ye-Zhan Zeng, Bei-Ji Zou, Xiao-Fang Wang, Frank Y Shih
BACKGROUND AND OBJECTIVE: Identifying liver regions from abdominal computed tomography (CT) volumes is an important task for computer-aided liver disease diagnosis and surgical planning. This paper presents a fully automatic method for liver segmentation from CT volumes based on graph cuts and border marching. METHODS: An initial slice is segmented by density peak clustering. Based on pixel- and patch-wise features, an intensity model and a PCA-based regional appearance model are developed to enhance the contrast between liver and background...
May 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28391246/influence-of-obesity-and-physical-workload-on-disability-benefits-among-construction-workers-followed-up-for-37-years
#8
Suzan J W Robroek, Bengt Järvholm, Allard J van der Beek, Karin I Proper, Jens Wahlström, Alex Burdorf
OBJECTIVES: The objectives of this study are to investigate the relation between obesity and labour force exit via diagnosis-specific disability benefits, and whether physical workload modifies this association. METHODS: A longitudinal analysis was performed among 3 28 743 Swedish construction workers in the age of 15-65 years. Body weight and height were measured at a health examination and enriched with register information on disability benefits up to 37 years later...
April 8, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28388953/a-randomized-controlled-study-on-the-efficacy-of-a-novel-combination-vaccine-against-enzootic-pneumonia-mycoplasma-hyopneumoniae-and-porcine-circovirus-type-2-pcv2-in-the-presence-of-strong-maternally-derived-pcv2-immunity-in-pigs
#9
Panagiotis D Tassis, Ioannis Tsakmakidis, Vassileios G Papatsiros, Dimitrios Koulialis, Tom Nell, Georgia Brellou, Eleni D Tzika
BACKGROUND: Mycoplasma hyopneumoniae (M. hyo) and Porcine Circovirus Type 2 (PCV2) are major pathogens that cause significant health problems in swine worldwide. Maternal derived immunity (MDI) has been suggested as a significant immediate defence factor for newborn piglets and may interfere with piglet's vaccination-induced immunity. The study aimed to assess the efficacy of a novel combination vaccine (consisting of PCV2 subunits and inactivated M. hyo strain J), against PCV2 and M...
April 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28379243/protic-ammonium-carboxylate-ionic-liquids-insight-into-structure-dynamics-and-thermophysical-properties-by-alkyl-group-functionalization
#10
Th Dhileep N Reddy, Bhabani S Mallik
This study is aimed at characterising the structure, dynamics and thermophysical properties of five alkylammonium carboxylate ionic liquids (ILs) from classical molecular dynamics simulations. The structural features of these ILs were characterised by calculating the site-site radial distribution functions, g(r), spatial distribution functions and structure factors. The structural properties demonstrate that ILs show greater interaction between cations and anions when alkyl chain length increases on the cation or anion...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28378579/a-click-chemistry-platform-for-the-rapid-synthesis-of-bispecific-molecules-for-inducing-protein-degradation
#11
Ryan P Wurz, Ken Dellamaggiore, Hannah Dou, Noelle Javier, Mei-Chu Lo, John D McCarter, Dane Mohl, Christine Sastri, J Russell Lipford, Victor J Cee
Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and proteasomal degradation of the target protein. The generation of effective PROTACs depends on the nature of the protein/ligase ligand pair, linkage site, linker length, and linker composition, all of which have been difficult to address in a systematic way. Herein, we describe a "click chemistry" approach for the synthesis of PROTACs...
April 5, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28373889/the-effects-of-modified-simiao-decoction-in-the-treatment-of-gouty-arthritis-a-systematic-review-and-meta-analysis
#12
REVIEW
Ya-Fei Liu, Ying Huang, Cai-Yu-Zhu Wen, Jun-Jun Zhang, Guo-Lan Xing, Sheng-Hao Tu, Zhe Chen
The modified Simiao decoctions (MSD) have been wildly applied in the treatment of gouty arthritis in China. However, the evidence needs to be evaluated by a systematic review and meta-analysis. After filtering, twenty-four randomised, controlled trials (RCTs) comparing the effects of MSD and anti-inflammation medications and/or urate-lowering therapies in patients with gouty arthritis were included. In comparison with anti-inflammation medications, urate-lowering therapies, or coadministration of anti-inflammation medications and urate-lowering therapies, MSD monotherapy significantly lowered serum uric acid (p < 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28371736/on-demand-dissolution-of-modular-synthetic-extracellular-matrix-reveals-local-epithelial-stromal-communication-networks
#13
Jorge Valdez, Christi D Cook, Caroline Chopko Ahrens, Alex J Wang, Alexander Brown, Manu Kumar, Linda Stockdale, Daniel Rothenberg, Kasper Renggli, Elizabeth Gordon, Douglas Lauffenburger, Forest White, Linda Griffith
Methods to parse paracrine epithelial-stromal communication networks are a vital need in drug development, as disruption of these networks underlies diseases ranging from cancer to endometriosis. Here, we describe a modular, synthetic, and dissolvable extracellular matrix (MSD-ECM) hydrogel that fosters functional 3D epithelial-stromal co-culture, and that can be dissolved on-demand to recover cells and paracrine signaling proteins intact for subsequent analysis. Specifically, synthetic polymer hydrogels, modified with cell-interacting adhesion motifs and crosslinked with peptides that include a substrate for cell-mediated proteolytic remodeling, can be rapidly dissolved by an engineered version of the microbial transpeptidase Sortase A (SrtA) if the crosslinking peptide includes a SrtA substrate motif and a soluble second substrate...
June 2017: Biomaterials
https://www.readbyqxmd.com/read/28366958/back-and-neck-pain-disability-and-upper-limb-symptoms-of-home-healthcare-workers-a-case-control-study-from-northern-italy
#14
Matteo Riccò, Federica Pezzetti, Carlo Signorelli
OBJECTIVES: Work-related musculoskeletal disorders (MSD) are quite frequent in healthcare workers (HCWs), but data about MSD in home-based healthcare workers (HHWs) are lacking. In this study we describe the prevalence of MSD among Italian HHWs. MATERIAL AND METHODS: A case-control study was carried out among 300 random-selected female HCWs, the sample comprising 100 HHWs, 100 HCWs with a low exposure to patient handling (MAPO - Movimentazione e Assistenza Pazienti Ospedalizzati - Movement and Assistance of Hospital Patients index 0-5) and 100 HCWs with high exposure to patient handling (MAPO index ≥ 5...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28357530/magnetic-resonance-imaging-of-first-trimester-pregnancy-expected-intrauterine-contents-in-relation-to-gestational-age
#15
Zachary J Viets, Constantine A Raptis, Kathryn J Fowler, Charles F Hildebolt, Motoyo Yano
PURPOSE: To determine if and when fetal structures are identifiable during first trimester pregnancy on magnetic resonance imaging (MRI) in women with acute abdominopelvic pain. METHODS: Sixty-four first trimester MRI examinations performed for evaluation of abdominopelvic pain were reviewed retrospectively. T2-weighted images were assessed independently by three radiologists for the presence of gestational sac, yolk sac, fetal pole, and limb buds. Mean sac diameter and sac volume were determined, and logistic regression analyses were performed...
March 29, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28353216/dissolution-comparisons-using-a-multivariate-statistical-distance-msd-test-and-a-comparison-of-various-approaches-for-calculating-the-measurements-of-dissolution-profile-comparison
#16
J-M Cardot, B Roudier, H Schütz
The f 2 test is generally used for comparing dissolution profiles. In cases of high variability, the f 2 test is not applicable, and the Multivariate Statistical Distance (MSD) test is frequently proposed as an alternative by the FDA and EMA. The guidelines provide only general recommendations. MSD tests can be performed either on raw data with or without time as a variable or on parameters of models. In addition, data can be limited-as in the case of the f 2 test-to dissolutions of up to 85% or to all available data...
March 28, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28333318/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#17
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
STUDY QUESTION: Is oral dydrogesterone 30 mg daily (10 mg three times daily [TID]) non-inferior to micronized vaginal progesterone (MVP) 600 mg daily (200 mg TID) for luteal support in in vitro fertilization (IVF), assessed by the presence of fetal heartbeats determined by transvaginal ultrasound at 12 weeks of gestation? SUMMARY ANSWER: Non-inferiority of oral dydrogesterone versus MVP was demonstrated at 12 weeks of gestation, with a difference in pregnancy rate and an associated confidence interval (CI) that were both within the non-inferiority margin...
May 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28327466/regional-deep-hyperthermia-impact-of-observer-variability-in-ct-based-manual-tissue-segmentation-on-a-simulated-temperature-distribution
#18
Bassim Aklan, Josefin Hartmann, Diana Zink, Hadi Siavooshhaghighi, Ricarda Merten, Florian Putz, Oliver Ott, Rainer Fietkau, Christoph Bert
The aim of this study was to systematically investigate the influence of inter- and intra-observer segmentation variation of tumor and organs at risk on the simulated temperature coverage of the target. CT scans of six patients with tumors in the pelvic region acquired for radiotherapy treatment planning were used for the hyperthermia treatment planning. To study the effect of inter-observer variation, three observers manually segmented in the CT images of each patient the following structures: fat, muscle, bone and bladder...
March 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28325585/gender-differences-in-demographic-and-clinical-correlates-among-veterans-with-musculoskeletal-disorders
#19
Diana M Higgins, Brenda T Fenton, Mary A Driscoll, Alicia A Heapy, Robert D Kerns, Matthew J Bair, Constance Carroll, Penny L Brennan, Diana J Burgess, John D Piette, Sally G Haskell, Cynthia A Brandt, Joseph L Goulet
BACKGROUND: Studies suggest that women may be at greater risk for developing chronic pain and pain-related disability. METHODS: Because musculoskeletal disorders (MSD) are the most frequently endorsed painful conditions among veterans, we sought to characterize gender differences in sociodemographic and clinical correlates among veterans upon entry into Veterans Health Administration's Musculoskeletal Disorders Cohort (n = 4,128,008). RESULTS: Women were more likely to be younger, Black, unmarried, and veterans of recent conflicts...
March 18, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28319267/risk-factors-associated-with-failure-of-treatment-for-cesarean-scar-pregnancy
#20
Ying-Cheng Chiang, Yi-An Tu, Jehn-Hsiahn Yang, Shin-Yu Lin, Chien-Nan Lee, Jin-Chung Shih
OBJECTIVE: To identify risk factors associated with treatment failure among women with cesarean scar pregnancy (CSP). METHODS: In a retrospective study, the medical records of patients with CSP treated at National Taiwan University Hospital, Taipei, Taiwan, from 1994 to 2015 were reviewed. The women were managed primarily with hysterotomy, evacuation, or methotrexate. Receiver operating characteristic (ROC) curve analysis and logistic regression analysis were used to evaluate the factors associated with treatment failure...
March 20, 2017: International Journal of Gynaecology and Obstetrics
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