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https://www.readbyqxmd.com/read/29166699/comparison-of-clinical-outcomes-of-coronary-artery-stent-implantation-in-patients-with-end-stage-chronic-kidney-disease-including-hemodialysis-for-three-everolimus-eluting-ees-stent-designs-bioresorbable-polymer-ees-platinum-chromium-ees-and-cobalt-chrome-ees
#1
Takao Sato, Katsuharu Hatada, Syohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Minoru Takahashi, Taku Matsubara, Masaaki Okabe, Yoshifusa Aizawa
BACKGROUNDS: New-generation bioresorbable polymer-everolimus eluting stents (BP-EES) are available. This study aimed to compare the clinical outcomes for BP-EES compared to more established stent designs, namely the platinum chromium-EES (PtCr-EES) and cobalt chrome-EES(CoCr-EES) in patients with the end-stage chronic kidney disease (CKD) including hemodialysis (HD). METHODS: One-hundred-forty-one consecutive stents (BP-EES [n = 44], PtCr-EES [n = 45], and CoCr-EES [n = 52]) were implanted in 104 patients with CKD...
November 22, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29157032/pain-fatigue-function-and-participation-among-long-term-manual-wheelchair-users-partnered-with-a-mobility-service-dog
#2
Claude Vincent, Dany H Gagnon, Frédéric Dumont
PURPOSE: To assess the effects of a mobility service dog (MSD) on pain, fatigue, wheelchair-related functional tasks, participation and satisfaction among manual wheelchair users over a nine-month period. METHOD: A longitudinal study with repeated assessment times before and three, six and nine months after intervention was achieved. Intervention consisted in partnering each participant with a MSD. The setting is a well-established provincial service dog training school and participants homes...
November 20, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29155316/influence-of-age-on-acute-and-chronic-gvhd-in-children-receiving-hla-identical-sibling-bmt-for-acute-leukemia-implications-for-prophylaxis
#3
Muna Qayed, Tao Wang, Michael T Hemmer, Stephen Spellman, Mukta Arora, Daniel Couriel, Amin Alousi, Joseph Pidala, Hisham Abdel-Azim, Mahmoud Aljuf, Mouhab Ayas, Menachem Bitan, Mitchell Cairo, Sung Won Choi, Christopher Dandoy, David Delgado, Robert Peter Gale, Gregory Hale, Haydar Frangoul, Rammurti T Kamble, Mohamed Kharfan-Dabaja, Leslie Lehman, John Levine, Margaret MacMillan, David I Marks, Taiga Nishihori, Richard F Olsson, Peiman Hematti, Olov Ringden, Ayman Saad, Prakash Satwani, Bipin N Savani, Kirk R Schultz, Sachiko Seo, Shalini Shenoy, Edmund K Waller, Lolie Yu, Mary M Horowitz, John Horan
Relapse remains the major cause of mortality post hematopoietic cell transplantation (HCT) for pediatric acute leukemia. Previous research suggests that reducing the intensity of calcineurin inhibitor based graft versus host disease (GVHD) prophylaxis may be an effective strategy in abrogating the risk of relapse in pediatric patients undergoing matched sibling donor (MSD) HCT. We reasoned that benefits of this strategy could be maximized by selectively applying it to those patients least likely to develop GVHD...
November 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29149980/incidence-of-infectious-complications-in-children-with-acute-lymphoblastic-leukemia-treated-with-hematopoietic-stem-cell-transplantation
#4
A Zaucha-Prażmo, J R Kowalczyk, K Drabko, K Czyżewski, J Goździk, O Zając-Spychała, J Wachowiak, J Frączkiewicz, E Gorczyńska, K Kałwak, J Styczyński
OBJECTIVE: We analyzed incidence and profile of infections in children with acute lymphoblastic leukemia (ALL) treated with hematopoietic stem cell transplantation (HSCT) in Polish pediatric HSCT departments, over a 2-year period. PATIENTS AND METHODS: Hospital records of 67 patients, who underwent allogeneic HSCT for ALL, were analyzed retrospectively for microbiologically documented infection: bacterial infection (BI), viral infection (VI), and fungal infection (FI)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29137385/improved-outcome-of-haploidentical-transplantation-in-severe-aplastic-anemia-using-reduced-intensity-fludarabine-based-conditioning
#5
Wu Yamei, Luo Rongmu, Cao Yongbin, Si Yingjian, Li Xiaohong, Zhang Xiaomei, Yan Pei, Du Zhenlan, Wang Haitao, Wang Jing, Wang Bojing, Wu Xiaoxiong, Da Wanming
Significant improvements in hematopoietic stem cell transplantation (HSCT) with haploidentical family donors (HFD) have confirmed its therapeutic role in severe aplastic anemia (SAA) and led to the evolution of treatment algorithms. However, the optimal conditioning regimen for HFD-HSCT remains undefined, especially the dosage of cyclophosphamide (Cy). A total of 77 patients with SAA from two research centers, who received HFD-HSCT with reduced-intensity fludarabine + cyclophosphamide + thymoglobulin ± busulfan conditioning regimen plus third-party cells infusion were included in this study, of which 67 pairs had 4-5 loci mismatched...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128598/histological-and-radiological-evaluation-of-subcutaneous-implants-in-mouse-of-a-3d-printable-material-fulcure-720-and-experimental-application-in-mandibular-reconstruction
#6
J Megías Barrera, L García-Consuegra, A Novoa, S Costilla, S Junquera, G Ascani
INTRODUCTION: The aim of this study was to evaluate the bioactivity of FullCure compared to porous polyethylene implants (Medpor) in rats prior to custom-made scaffold support manufacturing for mandible segmental defects (MSD) reconstruction in sheep. METHODS: 12 Fullcure and Medpor laminaes were implanted in the left and right dorsum respectively of 6 wistar rats. Toxicity was assessed by skin, kidney and liver histopathology 3 months post-implantation. Computed Tomography (CT) was carried out in order to assess radiological differences between implants...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29126116/c-621-15-w-and-others-v-sanofi-pasteur-an-example-of-judicial-distortion-and-indifference-to-science
#7
Laura R Smillie, Mark R Eccleston-Turner, Sarah L Cooper
This case commentary examines the CJEU's recent decision in C-621/15 W and Others v Sanofi Pasteur MSD SNC [2017] ECR I. This commentary critically examines the decision through the lens of the cultural conflict between law and science. We argue that the CJEU's decision reflects both a distortion of scientific knowledge and an improper indifference to the legitimate methods by which scientific knowledge is generated in the context of vaccines. These judicial approaches may, the authors argue, inadvertently fuel the vaccine scepticism that is growing across the developed world, and in particular in Europe...
November 8, 2017: Medical Law Review
https://www.readbyqxmd.com/read/29121051/process-evaluation-of-knowledge-transfer-across-industries-leveraging-coca-cola-s-supply-chain-expertise-for-medicine-availability-in-tanzania
#8
Erika Linnander, Christina T Yuan, Shirin Ahmed, Emily Cherlin, Kristina Talbert-Slagle, Leslie A Curry
Persistent gaps in the availability of essential medicines have slowed the achievement of global health targets. Despite the supply chain knowledge and expertise that ministries of health might glean from other industries, limited empirical research has examined the process of knowledge transfer from other industries into global public health. We examined a partnership designed to improve the availability of medical supplies in Tanzania by transferring knowledge from The Coca-Cola system to Tanzania's Medical Stores Department (MSD)...
2017: PloS One
https://www.readbyqxmd.com/read/29115204/use-of-the-smartphone-application-pregnant-with-diabetes
#9
Sidse Kjærhus Nørgaard, Vibeke Ladefoged Nichum, Charlotte Barfred, Hellen Marguerite Juul, Anna Lilja Secher, Lene Ringholm, Peter Damm, Elisabeth Reinhardt Mathiesen
INTRODUCTION: The aim of this article was to evaluate the awareness and use of the smartphone application (app) "Pregnant with Diabetes" locally, nationally and internationally. METHODS: In 2013, a patient initiated collaboration with the staff at Centre for Pregnant Women with Diabetes, Rigs-hospitalet, to develop the app "Pregnant with Diabetes". The app communicates clinically important antenatal health information to women with diabetes, based on recommendations from our centre...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29114726/concordance-between-different-amyloid-immunoassays-and-visual-amyloid-positron-emission-tomographic-assessment
#10
Shorena Janelidze, Josef Pannee, Alvydas Mikulskis, Ping Chiao, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Importance: Visual assessment of amyloid positron emission tomographic (PET) images has been approved by regulatory authorities for clinical use. Several immunoassays have been developed to measure β-amyloid (Aβ) 42 in cerebrospinal fluid (CSF). The agreement between CSF Aβ42 measures from different immunoassays and visual PET readings may influence the use of CSF biomarkers and/or amyloid PET assessment in clinical practice and trials. Objective: To determine the concordance between CSF Aβ42 levels measured using 5 different immunoassays and visual amyloid PET analysis...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29104228/work-life-imbalance-and-musculoskeletal-disorders-among-south-korean-workers
#11
Young-Mee Kim, Sung-Il Cho
Employed workers often have family responsibilities such as childcare or homemaking. This dual burden may increase work-related health problems, particularly if there are conflicts between work and family responsibilities. This study assessed whether difficulty in work-life balance is associated with musculoskeletal disorders (MSD) among Korean employees. Data from the population-based Korean Working Conditions Survey of 2011, including 28,640 male and 21,392 female workers, were used. Men and women were analyzed separately to investigate gender differences...
November 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29097718/attenuation-of-temporal-correlations-of-neuronal-oscillations-in-patients-with-mild-spastic-diplegia
#12
Fei Gao, Xiangci Wu, Yi Feng, Huibin Jia
The aim of this study was to investigate the temporal correlations of neuronal oscillations in patients with mild spastic diplegia (MSD). Resting-state electroencephalography (EEG) was recorded from 15 male adolescent and young adult patients with MSD and 15 healthy controls. We characterized the temporal correlations of neuronal oscillations, both on long temporal scale (i.e., >1 second) and short-to-intermediate temporal scale (i.e., <≈1 second) using detrended fluctuation analysis (DFA) and an analysis of the life- and waiting-time statistics of oscillation bursts respectively...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091642/orthotropic-elastic-moduli-of-biological-tissues-from-ultrasound-assisted-diffusing-wave-spectroscopy
#13
Dibbyan Mazumder, Gurudas Kar, Ram Mohan Vasu, Debasish Roy, Rajan Kanhirodan
We obtain vibro-acoustic (VA) spectral signatures of a remotely palpated region in tissue or tissue-like objects through diffusing-wave spectroscopy (DWS) measurements. Remote application of force is through focused ultrasound, and the spectral signatures correspond to vibrational modes of the focal volume (also called the ROI) excited through ultrasound forcing. In DWS, one recovers the time evolution of mean-square displacement (MSD) of Brownian particles from the measured decay of intensity autocorrelation of light, adapted also to local particles pertaining only to the ROI...
November 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29084202/role-of-thymoglobulin-in-matched-sibling-allogeneic-hematopoietic-stem-cell-transplantation-with-busulfan-and-fludarabine-conditioning-in-myeloid-malignanicies
#14
D-Y Shin, J-H Lee, S Park, J-O Lee, J-H Moon, J-S Ahn, Y Choi, I-C Song, H-J Shin, W S Lee, H S Lee, S-S Yoon
In vivo T-cell depletion using anti-thymocyte globulin (ATG) is widely used in allogeneic hematopoietic stem cell transplantation (HSCT) for prophylaxis of GvHD. We investigated the influence of thymoglobulin dose (an ATG) on GvHD following matched sibling donor (MSD) HSCT with a busulfan and fludarabine preparative regimen. Medical records of 180 patients who received MSD HSCT with a conditioning regimen of busulfan, fludarabine, and ATG (BuFluATG) were reviewed retrospectively. The median age was 53 years (range 18-68)...
October 30, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29083344/invasive-meningococcal-disease-on-the-workplaces-a-systematic-review
#15
Matteo Riccò, Luigi Vezzosi, Anna Odone, Carlo Signorelli
Background and aims of the work: Invasive Meningococcal Disease (IMD) represents a global health threat, and occupational settings have the potential to contribute to its spreading. Therefore, here we present the available evidences on the epidemiology of IMD on the workplaces. METHODS: The following key words were used to explore PubMed: Neisseria meningitidis, meningococcus, meningococcal, invasive meningococcal disease, epidemiology, outbreaks, profession(al), occupation(al). RESULTS: We identified a total of 12 IMD cases among healthcare workers (HCW), 44 involving biological laboratory workers (BLW), 8 among school personnel, and eventually 27 from other settings, including 3 large industrial working populations...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29079252/effect-of-an-intensified-multifactorial-intervention-on-cardiovascular-outcomes-and-mortality-in-type-2-diabetes-j-doit3-an-open-label-randomised-controlled-trial
#16
Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Masayuki Kato, Sumie Okahata, Hisayuki Katsuyama, Mikiko Haraguchi, Ai Morita, Ken Ohashi, Kazuo Hara, Atsushi Morise, Kazuo Izumi, Naoki Ishizuka, Yasuo Ohashi, Mitsuhiko Noda, Takashi Kadowaki
BACKGROUND: Limited evidence suggests that multifactorial interventions for control of glucose, blood pressure, and lipids reduce macrovascular complications and mortality in patients with type 2 diabetes. However, safe and effective treatment targets for these risk factors have not been determined for such interventions. METHODS: In this multicentre, open-label, randomised, parallel-group trial, undertaken at 81 clinical sites in Japan, we randomly assigned (1:1) patients with type 2 diabetes aged 45-69 years with hypertension, dyslipidaemia, or both, and an HbA1c of 6·9% (52·0 mmol/mol) or higher, to receive conventional therapy for glucose, blood pressure, and lipid control (targets: HbA1c <6·9% [52·0 mmol/mol], blood pressure <130/80 mm Hg, LDL cholesterol <120 mg/dL [or 100 mg/dL in patients with a history of coronary artery disease]) or intensive therapy (HbA1c <6·2% [44·3 mmol/mol], blood pressure <120/75 mm Hg, LDL cholesterol <80 mg/dL [or 70 mg/dL in patients with a history of coronary artery disease])...
October 24, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29078763/prevalence-of-musculoskeletal-disorders-among-school-teachers-from-urban-and-rural-areas-in-chuquisaca-bolivia-a-cross-sectional-study
#17
María Teresa Solis-Soto, Anabel Schön, Angel Solis-Soto, Manuel Parra, Katja Radon
BACKGROUND: Musculoskeletal disorders (MSD) are important health problems in working populations. The study aimed to determine the prevalence of MSD among school teachers from urban and rural areas in Chuquisaca, Bolivia. METHODS: A cross-sectional study was conducted in 60 randomly selected schools. In total, 1062 teachers were invited to participate (response 58%). The Spanish version of the Standardized Nordic questionnaire was used assessing the 12-months and 7-days prevalence of MSD as well as the 12-months prevalence of work limiting pain...
October 27, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29069963/radiological-analysis-of-minimal-safe-distance-and-optimal-screw-angle-to-avoid-facet-violation-in-open-door-laminoplasty-using-precontoured-plate
#18
Woo-Kie Min, Il Seo, Sang-Bong Na, Young-Seo Choi, Ji-Yeon Choi
PURPOSE: This study aimed to present radiologic analysis of minimal safe distance (MSD) and optimal screw angle (OSA) that enables to fix screws in a lateral mass safely without facet joint violation in open-door laminoplasty using a plate. METHODS: A retrospective analysis was made of 22 patients (male: 17; female: 5), average age 62 years. Seventy-nine lateral mass screws were fixed among a total of 158 screws. MSD that doesn't allow 5-mm screws to violate a facet joint was measured for C3-C7 and a comparative analysis was performed...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29065892/the-value-of-blood-cytokines-and-chemokines-in-assessing-copd
#19
Eric Bradford, Sean Jacobson, Jason Varasteh, Alejandro P Comellas, Prescott Woodruff, Wanda O'Neal, Dawn L DeMeo, Xingnan Li, Victor Kim, Michael Cho, Peter J Castaldi, Craig Hersh, Edwin K Silverman, James D Crapo, Katerina Kechris, Russell P Bowler
BACKGROUND: Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in multiple large well-characterized cohorts of susceptible current and former smokers. METHODS: We used two MSD multiplex panels to measure 9 cytokines and chemokines in 2123 subjects from COPDGene and 1117 subjects from SPIROMICS. These biomarkers included: interleukin (IL)-2, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, eotaxin/CCL-11, eotaxin-3/CCL-26, and thymus and activation-regulated chemokine (TARC)/CCL-17...
October 24, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29063945/a-screening-tool-for-the-risk-of-disability-retirement-due-to-musculoskeletal-disorders
#20
Rahman Shiri, Markku Heliövaara, Kirsi Ahola, Leena Kaila-Kangas, Eija Haukka, Johanna Kausto, Peppiina Saastamoinen, Päivi Leino-Arjas, Tea Lallukka
Objective This study aimed to develop and validate a risk screening tool using a points system to assess the risk of future disability retirement due to musculoskeletal disorders (MSD). Methods The development population, the Health 2000 Survey, consisted of a nationally representative sample of Finnish employees aged 30-60 years (N=3676) and the validation population, the Helsinki Health Study, consisted of employees of the City of Helsinki aged 40-60 years (N=6391). Both surveys were linked to data on disability retirement awards due to MSD from national register for an 11-year follow-up...
October 24, 2017: Scandinavian Journal of Work, Environment & Health
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