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https://www.readbyqxmd.com/read/28737249/haploidentical-transplantation-compared-with-matched-sibling%C3%A2-and-unrelated-donor-transplantation-for-adults-with-standard-risk-acute-lymphoblastic-leukaemia-in-first-complete-remission
#1
Li-Jie Han, Yu Wang, Zhi-Ping Fan, Fen Huang, Jian Zhou, Yue-Wen Fu, Hong Qu, Li Xuan, Na Xu, Jie-Yu Ye, Zhi-Lei Bian, Yong-Ping Song, Xiao-Jun Huang, Qi-Fa Liu
We retrospectively investigated outcomes of haploidentical donor (HID) transplant for adults with standard-risk acute lymphoblastic leukaemia (ALL) in first complete remission (CR1) compared with human leucocyte antigen (HLA)-matched sibling donor (MSD) and HLA-matched unrelated donor (MUD) transplants. A total of 348 adult patients were enrolled, including 127 HID, 144 MSD and 77 MUD recipients. The cumulative incidence of grade II-IV acute graft-versus-host disease (aGVHD) was 39·5%, 24·0% and 40·3% for HID, MSD and MUD, respectively (P = 0·020)...
July 24, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28736802/psychotropic-substances-in-house-dusts-a-preliminary-assessment
#2
Angelo Cecinato, Paola Romagnoli, Mattia Perilli, Catia Balducci
Psychotropic substances (PSs) are known to affect air and waters, while scarce attention has been paid to their occurrence in settled dusts although they can reach important concentrations there; moreover, no procedures have been developed for this specific purpose. In this study, a list of PSs (i.e., nicotine, cotinine, caffeine, cocaine, cannabinol, Δ(9)-tetrahydrocannabinol, cannabidiol, amphetamine, heroin, and methadone) were characterized in dusts from Rome and Fiumicino international airport, Italy, and from Ouargla city, Algeria...
July 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28733215/development-of-nanoluc-bridging-immunoassay-for-detection-of-anti-drug-antibodies
#3
Nidhi Nath, Rod Flemming, Becky Godat, Marjeta Urh
Anti-drug antibodies (ADAs) are generated in-vivo as an immune response to therapeutic antibody drugs and can significantly affect the efficacy and safety of the drugs. Hence, detection of ADAs is recommended by regulatory agencies during drug development process. A widely accepted method for measuring ADAs is "bridging" immunoassay and is frequently performed using enzyme-linked immunosorbent assay (ELISA) or electrochemiluminescence (ECL) platform developed by Meso Scale Discovery (MSD). ELISA is preferable due to widely available reagents and instruments and broad familiarity with the technology; however, MSD platform has gained wide acceptability due to a simpler workflow, higher sensitivity, and a broad dynamic range but requires proprietary reagents and instruments...
July 18, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28732397/combined-sewer-overflow-events-and-childhood-emergency-department-visits-a-case-crossover-study
#4
Cole Brokamp, Andrew F Beck, Louis Muglia, Patrick Ryan
In localities with combined sewer systems, combined sewer overflow (CSO) events frequently occur following high precipitation and can result in the release of untreated sewage and industrial wastewater into surface waters. We hypothesized that either direct contact with or proximity to aerosolized CSO effluent would increase the risk for childhood emergency department (ED) visits for asthma, gastrointestinal (GI) illnesses, and skin and soft tissue infections (SSTIs) in Cincinnati, OH, USA. ED visits for 2010-2014 due to GI diseases, asthma, and SSTIs were extracted from the Cincinnati Children's Hospital Medical Center electronic health records...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28720536/a-diffusing-wave-spectroscopy-study-of-pharmaceutical-emulsions-for-physical-stability-assessment
#5
Andreas Niederquell, Alexandra H E Machado, Martin Kuentz
Emulsions are broadly used in pharmaceutics either as intermediate products or as final dosage forms. Such disperse systems are only kinetically stabilized and therefore early detection of physical instability is highly desirable. This work employed diffusing wave spectroscopy (DWS) to study a series of model emulsions that were categorized, based on their composition, as either "simple" or "complex". DWS data were compared with results of droplet size imaging, apparent viscosity obtained by microfluidics, and near-infrared (NIR) analytical centrifugation...
July 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28708393/selective-deamination-of-mutagens-by-a-mycobacterial-enzyme
#6
Vandana Gaded, Ruchi Anand
Structure-based methods are powerful tools that are being exploited to unravel new functions with therapeutic advantage. Here, we report the discovery of a new class of deaminases, predominantly found in mycobacterial species that act on the commercially important s-triazine class of compounds. The enzyme, Msd from Mycobacterium smegmatis was taken as a representative candidate from an evolutionarily conserved sub-group that possesses high density of Mycobacterium deaminases. Biochemical investigation reveals that Msd specifically acts on mutagenic nucleobases like 5-azacytosine and isoguanine, and does not accept natural bases as substrates...
July 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28704995/molecular-dynamics-simulations-of-amide-functionalized-imidazolium-bis-trifluoromethanesulfonyl-imide-dicationic-ionic-liquids
#7
Hassan Khakan, Saeid Yeganegi
In the present study the structure and dynamics of three dicationic ionic liquids (DILs) with a functional amide group in the imidazolium ring with bis(trifluoromethanesulfonyl)imide, [TFSI]- anion has been studied by molecular dynamics simulations. Densities, radius distribution functions (RDFs), combined distribution functions (CDFs), spatial distribution functions (SDFs), mean-square displacements (MSD), and self-diffusivities for the ions have been calculated from MD simulations. The calculated densities for [C4(amim)2][TFSI]2 at different temperatures agreed well with the experimental values...
July 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28686131/occupational-health-and-safety-management-practices-and-musculoskeletal-disorders-in-aged-care
#8
Jodi Oakman, Timothy Bartram
Purpose The purpose of this paper is to examine whether occupational health and safety (OHS) management used to manage musculoskeletal disorders (MSDs) in the aged care sector reflects contemporary research evidence of best practice to reduce the incidence of these disorders. Design/methodology/approach In total, 58 interviews were conducted with managers and supervisors in the aged care sector across four organisations in Australia. Policies and procedures relating to MSDs were reviewed for each organisation...
May 15, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28681215/consequences-of-increases-in-antibiotic-resistance-pattern-on-outcome-of-pancreatic-resection-for-cancer
#9
Luca Gianotti, Nicolò Tamini, Francesca Gavazzi, Anna Mariani, Marta Sandini, Fabio Ferla, Marco Cereda, Giovanni Capretti, Stefano Di Sandro, Davide Paolo Bernasconi, Luciano De Carlis, Alessandro Zerbi
BACKGROUND: The role of drug-resistance infections on surgical outcomes is controversial. The aim of the study was to determine whether increase antibiotic resistance was an independent risk factor for development of major non-infectious postoperative complications. METHODS: This work included a multicenter cohort study of patients who underwent pancreatic resections for cancer over a 3-year interval. The primary outcome was major non-infectious complication rate developing after the occurrence of multi-drug sensitive (MDS) infection, multi-drug-resistant infection (MDR), and extensive drug-resistant (XDR) infection...
July 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28662690/comparative-efficacy-of-a-new-spot-on-combination-product-containing-selamectin-and-sarolaner-stronghold%C3%A2-plus-versus-fluralaner-bravecto%C3%A2-against-induced-infestations-with-ixodes-ricinus-ticks-on-cats
#10
Thomas Geurden, Stasia Borowski, Magda Wozniakiewicz, Vickie King, Josephus Fourie, Julian Liebenberg
BACKGROUND: Ticks are increasingly reported on cats worldwide, with Ixodes ricinus being a relevant species across Europe and in near by areas of North Africa and the Middle East. Yet there are few acaracidal products with proven efficacy approved for use in cats. The objective of this study was to compare the efficacy of a new spot-on formulation containing selamectin and sarolaner with a topical application of fluralaner (Bravecto®) against Ixodes ricinus ticks on cats. To that end, twenty-four (24) cats were randomly allocated to one of three treatment groups...
June 29, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28653070/colloidal-diffusion-over-a-quenched-two-dimensional-random-potential
#11
Yun Su, Xiao-Guang Ma, Pik-Yin Lai, Penger Tong
A two-layer colloidal system is developed for the study of diffusion over a quenched two-dimensional random potential. A mixture of bidisperse silica spheres is used to form a randomly packed colloidal monolayer on the bottom substrate. The corrugated surface of the bottom colloidal monolayer provides a gravitational potential field for the dilute diffusing particles in the top layer. The population probability histogram P(x,y) of the diffusing particles is obtained to fully characterize the random potential landscape U(x,y) via the Boltzmann distribution...
July 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28650514/automatic-segmentation-of-the-spine-by-means-of-a-probabilistic-atlas-with-a-special-focus-on-ribs-suppression
#12
Silvia Ruiz-España, Juan Domingo, Antonio Díaz-Parra, Esther Dura, Víctor D'Ocón-Alcañiz, Estanislao Arana, David Moratal
PURPOSE: The development of automatic and reliable algorithms for the detection and segmentation of the vertebrae are of great importance prior to any diagnostic task. However, an important problem found to accurately segment the vertebrae is the presence of the ribs in the thoracic region. To overcome this problem, a probabilistic atlas of the spine has been developed dealing with the proximity of other structures, with a special focus on ribs suppression. METHODS: The data sets used consist of Computed Tomography images corresponding to 21 patients suffering from spinal metastases...
June 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28633449/night-work-as-a-risk-factor-of-future-disability-pension-due-to-musculoskeletal-diagnoses-a-prospective-cohort-study-of-swedish-twins
#13
Sanna Kärkkäinen, Annina Ropponen, Jurgita Narusyte, Lisa Mather, Torbjörn Åkerstedt, Karri Silventoinen, Ellenor Mittendorfer-Rutz, Pia Svedberg
Background: This study investigated the associations between night work, sleep and disability pension (DP) due to musculoskeletal disorders (MSD), while controlling for several confounding factors including both genetic factors and shared family background. Methods: The study sample consisted of 27 165 Swedish twin individuals born in 1935-58 with comprehensive survey data on sociodemographic, health and lifestyle factors. Night work was assessed as years of working hours at night at least every now and then, and categorized into 'not at all, 1-10 years and over 10 years'...
June 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28617528/influence-of-ablation-therapy-on-the-quality-of-life-in-children-with-supraventricular-tachycardia
#14
E Szafran, A Baszko, A Bukowska-Posadzy, A Łaźniak, T Moszura, A Siwińska, J Walkowiak, W Bobkowski
OBJECTIVE: Numerous restrictions, which are imposed on children with arrhythmia, influence their quality of life (QoL) and may have a negative impact on their further development. Ablation is a highly successful treatment leaving patients free from arrhythmia and other related limitations. There are very few studies evaluating the influence of ablation on the QoL in children with arrhythmia, based on small groups of patients. The aim of this study was to evaluate the impact of ablation on the QoL in children with supraventricular tachycardia (SVT)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28610569/a-novel-tamponade-agent-for-management-of-post-partum-hemorrhage-adaptation-of-the-xstat-mini-sponge-applicator-for-obstetric-use
#15
Maria I Rodriguez, Jeffrey T Jensen, Kenton Gregory, Mary Bullard, Paul Longo, Jerry Heidel, Alison Edelman
BACKGROUND: Although uterine tamponade is an effective treatment for postpartum hemorrhage (PPH), current methods have key limitations in their use, particularly in low resource settings. The XStat™ Mini Sponge Dressing (MSD) is approved for the management of non-compressible wounds in the battlefield/trauma setting. The MSD applies highly compressed medical sponges capable of stopping high-flow arterial bleeding within seconds. The objective of our study was to adopt the MSD for use in managing PPH...
June 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28605693/evaluation-of-flunixin-meglumine-pour-on-administration-on-prostaglandin-e2-concentration-in-inflammatory-exudate-after-induction-of-inflammation-in-cattle
#16
Julien Thiry, René Fournier, Olivier Roy, Mathias Catala
The effect of flunixin transdermal pour-on solution (Finadyne® Transdermal; MSD Animal Health) on prostaglandin E2 (PGE2) synthesis in bovine inflammatory exudate was evaluated in a tissue cage model of acute inflammation. Twelve calves were randomly allocated to two-treatment groups over two sequences. Three weeks prior to the first period, sterile hollow perforated polyethylene balls were surgically embedded in the subcutis at four distinct sites in each animal. On the first day of each period, an aseptic inflammation was induced by injecting 0...
April 20, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28597921/feasibility-of-canine-detection-of-mass-storage-devices-a-study-of-volatile-organic-compounds-emanating-from-electronic-devices-using-solid-phase-microextraction
#17
Lauryn E DeGreeff, Michelle Cerreta, Mark Rispoli
Detection of canines are well-known to be valuable in the location of contraband, such as explosives or narcotics. More recently, canines have been trained and utilized in the detection of concealed mass storage devices that might contain evidence of illegal activity such as child pornography. To lay the analytical foundation for this detection work, research was carried out to determine the volatile organic compounds associated with mass storage devices (MSD) that could be used by trained canines for detection...
June 9, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28597314/deltamethrin-as-inductor-agent-of-precocious-ovarian-degeneration-in-rhipicephalus-sanguineus-s-l-acari-ixodidae-ticks
#18
Maria Izabel Camargo-Mathias, Natalia Rubio Claret Pereira, Camila da Silva Reis, Cristiane Regina de Almeida, Douglas Rodrigo Dos Santos Mendes, Giselle Bezerra de Araújo, Lays Postali, Tober Figueroa, Allan Roberto Fernandes Ferreira, Juan Parente Santos, Patrícia Rosa de Oliveira
The cosmopolitan species Rhipicephalus sanguineus s.l. is one of the most widely distributed ticks all over the world. These ectoparasites are vectors of several pathogens and cause significant direct damage to their hosts. The biological success of these ectoparasites has been attributed to their ovaries and salivary glands, organs that ensure their survival in various environmental conditions. The importance of the ovaries in ticks is that, after mating, the individuals are able to lay approximately three thousand eggs...
June 8, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28592329/autoimmune-antibody-decline-in-parkinson-s-disease-and-multiple-system-atrophy-a-step-towards-immunotherapeutic-strategies
#19
Tomasz Brudek, Kristian Winge, Jonas Folke, Søren Christensen, Karina Fog, Bente Pakkenberg, Lars Østergaard Pedersen
BACKGROUND: Parkinson's' disease (PD) and Multiple System Atrophy (MSA) are progressive brain disorders characterized by intracellular accumulations of α-synuclein and nerve cell loss in specific brain areas. This loss causes problems with movement, balance and/or autonomic functions. Naturally occurring autoantibodies (NAbs) play potentially an important role in clearing or/and blocking circulating pathological proteins. Little is known about the functional properties of anti-α-synuclein NAbs in PD and MSA, and there have been opposing reports regarding their plasma concentrations in these disorders...
June 7, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28589493/a-randomized-placebo-controlled-trial-evaluating-the-safety-and-efficacy-of-adding-omarigliptin-to-antihyperglycemic-therapies-in-japanese-patients-with-type-2-diabetes-and-inadequate-glycemic-control
#20
Ira Gantz, Taro Okamoto, Yuka Ito, Asako Sato, Kotoba Okuyama, Edward A O'Neill, Samuel S Engel, Eseng Lai
INTRODUCTION: Daily dipeptidyl peptidase-4 (DPP-4) inhibitors are commonly used with other orally administered antihyperglycemic agents (AHA), as combination therapy, to treat Japanese patients with type 2 diabetes. When combination therapy is indicated, use of a once-weekly (q.w.) orally administered DPP-4 inhibitor might be an appropriate therapeutic option for some patients. METHODS: A 52-week trial was conducted to assess the safety and tolerability (primary objectives) and glycemic efficacy (secondary objectives) of the q...
June 6, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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