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mean platelet volume and preeclampsia

Min-A Kim, Gwan Hee Han, Ja-Young Kwon, Young-Han Kim
PROBLEM: Preeclampsia (PE) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed to investigate the clinical effectiveness of the platelet-to-lymphocyte ratio (PLR) in women with PE and compare this measurement to platelet indices as a diagnostic and prognostic marker of PE. METHOD OF STUDY: A total of 471 healthy pregnant women, 126 women diagnosed with mild PE, and 227 with severe PE were included in this retrospective study...
May 21, 2018: American Journal of Reproductive Immunology: AJRI
Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng
Preeclampsia (PE) is a pregnancy-specific, multi-system disorder and the leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. Excessive vasoconstriction and dysregulated coagulation function are closely associated with PE. Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and has important roles in vascular dilatation and suppression of platelet aggregation. However, the role of HSP20 in the pathogenesis of PE remains unclear. In this study, we collected chorionic plate resistance arteries (CPAs) and serum from 118 healthy pregnant women and 80 women with PE and detected the levels of HSP20 and its phosphorylated form...
March 9, 2018: Frontiers of Medicine
Mahmoud M Elgari, Omar F Khabour, Samaher M Alhag
Preeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty normal pregnant mothers served as controls. Hematological parameters that include hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell counts (WBC), platelet counts, mean platelet volume (MPV) and Platelet large cell ratio (PLCR) were examined...
February 23, 2018: Clinical and Experimental Hypertension: CHE
Dominique Mannaerts, Suzanne Heyvaert, Chania De Cordt, Claartje Macken, Charlotte Loos, Yves Jacquemyn
OBJECTIVE: Preeclampsia (PE) is a severe pregnancy complication with significant maternal and neonatal morbi-mortality resulting in high health care costs. Prevention, mainly based on the administration of acetylsalicylic acid, is only possible if timely identification of high-risk patients can be realized in an easy, nonexpensive, and widely available method. This paper explores the clinical usability of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) in discriminating between women that will and those that will not develop PE...
December 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
Ying Chen, Li Lin
BACKGROUND: Preeclampsia is a relatively common complication of pregnancy and considered to be associated with different degrees of coagulation dysfunction. This study was developed to evaluate the potential value of coagulation parameters for suggesting preeclampsia during the third trimester of pregnancy. MATERIALS AND METHODS: Data from 188 healthy pregnant women, 125 patients with preeclampsia in the third trimester and 120 age-matched nonpregnant women were analyzed...
July 2017: American Journal of the Medical Sciences
Jesús Antonio Viana-Rojas, Alejandro Rosas-Cabral, Jorge Prieto-Macías, Ma Carmen Terrones-Saldívar, Patricia Arcos-Noguez, Julieta Bermúdez-Gómez, Lidia Estephanie Martínez-Padilla, Darío Alejandro Sandoval-Valdez, Flavio Hernández-González, Leopoldo César Serrano-Díaz
BACKGROUND: It has been established a strong association between the red cell distribution width (RDW) and mean platelet volume (MPV) with hypertension in non-pregnant patients. However, few studies have been performed in patients with preeclampsia, yielding inconsistent results. Our aim is to evaluate the relationship between RDW and MPV with the severity of preeclampsia. METHODS: Analytic cross-sectional study. We include 64 patients with preeclampsia (26 mild, 38 severe) and 70 patients with normotensive pregnancy...
March 2017: Revista Médica del Instituto Mexicano del Seguro Social
Burak Yücel, Batuhan Ustun
INTRODUCTION AND AIM: Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW) and plateletcrit (PCT) have all been recognized as systemic inflammatory response (SIR) markers. Our aim was to evaluate changes in NLR, PLR, RDW, MPV and PCT in preeclampsia and their use in predicting the severity of PE. STUDY DESIGN: This retrospective cohort study included 219 patients. Of them, 27 had mild PE, 82 had severe PE, and 110 were healthy, normotensive pregnant patients...
January 2017: Pregnancy Hypertension
Muneera A AlSheeha, Rafi S Alaboudi, Mohammad A Alghasham, Javed Iqbal, Ishag Adam
BACKGROUND: Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia. OBJECTIVE: To compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls. SETTING: Qassim Hospital, Kingdom of Saudi Arabia. DESIGN: A case-control study...
2016: Vascular Health and Risk Management
Şafak Özdemirci, Emre Başer, Taner Kasapoğlu, Ertuğrul Karahanoğlu, Inci Kahyaoglu, Serdar Yalvaç, Ömer Tapısız
INTRODUCTION: To evaluate the predictive and clinical utilization of the mean platelet volume (MPV) in severe preeclamptic women. MPV is known as platelet size and associated with platelet activation or new platelet synthesis. Platelet count is decreased by vascular endothelial damage in cases of severe preeclampsia. It leads to increased turnover of platelets. METHODS: The severe preeclamptic women with and without preeclampsia during pregnancy were divided into subgroups depending on the gestational birth week early, (<34), late (34-37) preterm birth and term (≥37) gestational weeks...
November 2016: Hypertension in Pregnancy
Daniela Moraes, Terezinha Paz Munhoz, Bartira E Pinheiro da Costa, Marta Ribeiro Hentschke, Fernando Sontag, Luiza Silveira Lucas, Giovani Gadonski, Ivan Carlos Antonello, Carlos E Poli-de-Figueiredo
BACKGROUND: Imbalance in hemostatic mechanisms can occur during pregnancy with a tendency for hypercoagulability and increased thrombosis risk. Pregnant women with hypertensive disorder, especially preeclampsia, show alterations in platelet indexes. Immature platelet fraction (IPF) has been suggested as a sensitive index for monitoring changes in platelet production and destruction. OBJECTIVES: To evaluate the IPF in patients diagnosed with a gestational hypertensive disorder (GHD)...
June 2016: Platelets
Keziban Doğan, Hakan Guraslan, Mehmet Baki Senturk, Caglar Helvacioglu, Sevda İdil, Murat Ekin
OBJECTIVE: To compare the hematocrit, platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), PC to MPV ratio in the mild preeclamptic (mPE), severe preeclamptic (sPE) and healthy normotensive pregnant women to evaluate whether these parameters have a predictive and prognostic significance in determining the risk and the severity of preeclampsia (PE). METHODS: A retrospective case-control study was designed including the patient population (N = 284) composed of 49 mPE, 70 sPE, 165 healthy normotensive pregnant women for controls...
November 2015: Hypertension in Pregnancy
Atilla Karateke, Raziye Keskin Kurt, Ali Baloğlu
OBJECTIVE: While the relationship between platelet crit (PCT), platelet distribution width (PDW) and hypertension has been well-documented, data on the association between PCT, PDW and preeclampsia are scant at best. In our study we aimed to investigate the possible correlation of PCT and PDW with preeclampsia and disease severity MATERIAL AND METHODS: A total of 110 preeclamptic and 100 healthy pregnant women were included in the study Baseline PCT and PDW were measured using an automatic blood counterin the entire study population...
May 2015: Ginekologia Polska
Lei Han, Xiaojie Liu, Hongmei Li, Jiaqun Zou, Zhiling Yang, Jian Han, Wei Huang, Lili Yu, Yingru Zheng, Li Li
BACKGROUND: Preeclampsia (PE) is an obstetric disorder with high morbidity and mortality rates but without clear pathogeny. The dysfunction of the blood coagulation-fibrinolysis system is a salient characteristic of PE that varies in severity, and necessitates different treatments. Therefore, it is necessary to find suitable predictors for the onset and severity of PE. OBJECTIVES: We aimed to evaluate blood coagulation parameters and platelet indices as potential predictors for the onset and severity of PE...
2014: PloS One
Ali Yavuzcan, Mete Cağlar, Yusuf Ustün, Serdar Dilbaz, Ismail Ozdemir, Elif Yildiz, Sitki Ozbilgeç, Selahattin Kumru
OBJECTIVES: The aim of the study was to compare the changes in the values of leukocytes, neutrophils, lymphocytes, mean platelet volume (MPV), and systemic inflammatory response (SIR) markers (neutrophil-lymphocyte ratio/ platelet-lymphocyte ratio) in patients with severe preeclampsia (PE) of healthy pregnant and non-pregnant women. MATERIAL AND METHODS: Hematological parameters including MPV and SIR markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] were compered between the between three groups comprising of women with severe PE, healthy pregnant women and healthy non-pregnant women...
March 2014: Ginekologia Polska
Seung Woo Yang, Soo Hyun Cho, Han Sung Kwon, In Sook Sohn, Han Sung Hwang
OBJECTIVE: To evaluate the platelet distribution width (PDW) and other platelet indices as potential severity markers of preeclampsia (PE). STUDY DESIGN: A total of 935 pregnant women who had received continuous prenatal care and had undergone delivery were included. The participants were classified into 3 groups: healthy pregnant women (n=816), pregnant women with mild PE (n=59), and pregnant women with severe PE (n=60). Blood samples were collected during antenatal care or at the time of admission, and the platelet indices were compared among the three groups...
April 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Letícia Gonçalves Freitas, Patrícia Nessralla Alpoim, Flávia Komatsuzaki, Maria das Graças Carvalho, Luci Maria S Dusse
INTRODUCTION: Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th week gestation. The aim of this study was to investigate whether platelet count (PC) and platelet indices (mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT)) could predict severe form of preeclampsia (sPE). METHODS: Three groups were evaluated; G1-pregnant with sPE (N = 29); G2-normotensive pregnant (N = 28) and Group 3: non-pregnant women (N = 30)...
November 2013: Hematology (Amsterdam, Netherlands)
Leslie Myatt, Rebecca G Clifton, James M Roberts, Catherine Y Spong, John C Hauth, Michael W Varner, John M Thorp, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Marshall W Carpenter, Jay D Iams, Anthony Sciscione, Margaret Harper, Jorge E Tolosa, George Saade, Yoram Sorokin, Garland D Anderson
OBJECTIVE: To identify clinical characteristics and biochemical markers in first-trimester samples that would possibly predict the subsequent development of preeclampsia. METHODS: We conducted a multicenter observational study in 2,434 nulliparous women at low risk to identify biomarkers that possibly predict preeclampsia. Clinical history, complete blood count, and biochemical markers were assessed in the first trimester. The trophoblast and angiogenesis markers ADAM-12, pregnancy-associated plasma protein-A, placental protein 13, placental growth factor, soluble fms-like tyrosine kinase-1, and endoglin were measured in a case-control subset of 174 women with preeclampsia and 509 women in the control group...
June 2012: Obstetrics and Gynecology
Li-jun Zhang, Yu-huan Han, Yu-zhi Han
OBJECTIVE: To investigate the expression levels of serum soluble Endoglin (sEng), plasma endothelin-1 (ET-1) and coagulation function in patients suffering from early onset severe preeclampsia with organ dysfunction, and to analyze the clinical significance. METHODS: Forty-nine early onset severe preeclampsia patients were enrolled in the study group, including 26 cases without organ dysfunction (study group I) and 23 cases with organ dysfunction (study group II)...
June 2010: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
Odül A Amburgey, Eliesa Ing, Gary J Badger, Ira M Bernstein
OBJECTIVE: Maternal hemoglobin concentration is inversely related to newborn size presumably through plasma volume constriction. We sought to determine whether birth weight would show an inverse relationship to hemoglobin concentration in a group of infants whose mothers had preeclampsia, where plasma volume constriction is common. METHODS: Electronic and paper chart review identified 142 nulliparous women with preeclampsia (excluding hemolysis, elevated liver enzymes, low platelets syndrome)...
September 2009: Journal of Maternal-fetal & Neonatal Medicine
Jun-Ho Wu, Hung-Chieh Chou, Pau-Chung Chen, Suh-Fang Jeng, Chien-Yi Chen, Po-Nien Tsao, Chia-Jung Hsieh, Hsiu-Min Huang, Wu-Shiun Hsieh
AIM: Reference ranges of haematological parameters in preterm infants are limited. The aim of this study is to determine the reference values of haematological parameters in preterm infants in Taiwan, and to assess the impact of gestational age and mode of delivery on these parameters. METHOD: Medical records were retrospectively reviewed in preterm infants admitted to National Taiwan University Hospital from January 2001 to December 2004. The inclusion criteria included infants with <37 weeks of gestation who had blood sampling within 24 h of birth...
June 2009: Journal of Paediatrics and Child Health
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