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mean platelet volume and preeclampsia

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https://www.readbyqxmd.com/read/27920548/platelet-count-and-platelet-indices-in-women-with-preeclampsia
#1
Muneera A AlSheeha, Rafi S Alaboudi, Mohammad A Alghasham, Javed Iqbal, Ishag Adam
BACKGROUND: Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia. OBJECTIVE: To compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls. SETTING: Qassim Hospital, Kingdom of Saudi Arabia. DESIGN: A case-control study...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27314286/predictivity-of-mean-platelet-volume-in-severe-preeclamptic-women
#2
Şafak Özdemirci, Emre Başer, Taner Kasapoğlu, Ertuğrul Karahanoğlu, Inci Kahyaoglu, Serdar Yalvaç, Ömer Tapısız
INTRODUCTION: To evaluate the predictive and clinical utilization of the mean platelet volume (MPV) in severe preeclamptic women. MPV is known as platelet size and associated with platelet activation or new platelet synthesis. Platelet count is decreased by vascular endothelial damage in cases of severe preeclampsia. It leads to increased turnover of platelets. METHODS: The severe preeclamptic women with and without preeclampsia during pregnancy were divided into subgroups depending on the gestational birth week early, (<34), late (34-37) preterm birth and term (≥37) gestational weeks...
June 17, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/26587995/immature-platelet-fraction-in-hypertensive-pregnancy
#3
Daniela Moraes, Terezinha Paz Munhoz, Bartira E Pinheiro da Costa, Marta Ribeiro Hentschke, Fernando Sontag, Luiza Silveira Lucas, Giovani Gadonski, Ivan Carlos Antonello, Carlos E Poli-de-Figueiredo
BACKGROUND: Imbalance in hemostatic mechanisms can occur during pregnancy with a tendency for hypercoagulability and increased thrombosis risk. Pregnant women with hypertensive disorder, especially preeclampsia, show alterations in platelet indexes. Immature platelet fraction (IPF) has been suggested as a sensitive index for monitoring changes in platelet production and destruction. OBJECTIVES: To evaluate the IPF in patients diagnosed with a gestational hypertensive disorder (GHD)...
June 2016: Platelets
https://www.readbyqxmd.com/read/26362129/can-platelet-count-and-platelet-indices-predict-the-risk-and-the-prognosis-of-preeclampsia
#4
Keziban Doğan, Hakan Guraslan, Mehmet Baki Senturk, Caglar Helvacioglu, Sevda İdil, Murat Ekin
OBJECTIVE: To compare the hematocrit, platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), PC to MPV ratio in the mild preeclamptic (mPE), severe preeclamptic (sPE) and healthy normotensive pregnant women to evaluate whether these parameters have a predictive and prognostic significance in determining the risk and the severity of preeclampsia (PE). METHODS: A retrospective case-control study was designed including the patient population (N = 284) composed of 49 mPE, 70 sPE, 165 healthy normotensive pregnant women for controls...
November 2015: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/26117976/relation-of-platelet-distribution-width-pdw-and-platelet-crit-pct-to-preeclampsia
#5
COMPARATIVE STUDY
Atilla Karateke, Raziye Keskin Kurt, Ali Baloğlu
OBJECTIVE: While the relationship between platelet crit (PCT), platelet distribution width (PDW) and hypertension has been well-documented, data on the association between PCT, PDW and preeclampsia are scant at best. In our study we aimed to investigate the possible correlation of PCT and PDW with preeclampsia and disease severity MATERIAL AND METHODS: A total of 110 preeclamptic and 100 healthy pregnant women were included in the study Baseline PCT and PDW were measured using an automatic blood counterin the entire study population...
May 2015: Ginekologia Polska
https://www.readbyqxmd.com/read/25464515/blood-coagulation-parameters-and-platelet-indices-changes-in-normal-and-preeclamptic-pregnancies-and-predictive-values-for-preeclampsia
#6
Lei Han, Xiaojie Liu, Hongmei Li, Jiaqun Zou, Zhiling Yang, Jian Han, Wei Huang, Lili Yu, Yingru Zheng, Li Li
BACKGROUND: Preeclampsia (PE) is an obstetric disorder with high morbidity and mortality rates but without clear pathogeny. The dysfunction of the blood coagulation-fibrinolysis system is a salient characteristic of PE that varies in severity, and necessitates different treatments. Therefore, it is necessary to find suitable predictors for the onset and severity of PE. OBJECTIVES: We aimed to evaluate blood coagulation parameters and platelet indices as potential predictors for the onset and severity of PE...
2014: PloS One
https://www.readbyqxmd.com/read/24783431/mean-platelet-volume-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-severe-preeclampsia
#7
COMPARATIVE STUDY
Ali Yavuzcan, Mete Cağlar, Yusuf Ustün, Serdar Dilbaz, Ismail Ozdemir, Elif Yildiz, Sitki Ozbilgeç, Selahattin Kumru
OBJECTIVES: The aim of the study was to compare the changes in the values of leukocytes, neutrophils, lymphocytes, mean platelet volume (MPV), and systemic inflammatory response (SIR) markers (neutrophil-lymphocyte ratio/ platelet-lymphocyte ratio) in patients with severe preeclampsia (PE) of healthy pregnant and non-pregnant women. MATERIAL AND METHODS: Hematological parameters including MPV and SIR markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] were compered between the between three groups comprising of women with severe PE, healthy pregnant women and healthy non-pregnant women...
March 2014: Ginekologia Polska
https://www.readbyqxmd.com/read/24502873/significance-of-the-platelet-distribution-width-as-a-severity-marker-for-the-development-of-preeclampsia
#8
Seung Woo Yang, Soo Hyun Cho, Han Sung Kwon, In Sook Sohn, Han Sung Hwang
OBJECTIVE: To evaluate the platelet distribution width (PDW) and other platelet indices as potential severity markers of preeclampsia (PE). STUDY DESIGN: A total of 935 pregnant women who had received continuous prenatal care and had undergone delivery were included. The participants were classified into 3 groups: healthy pregnant women (n=816), pregnant women with mild PE (n=59), and pregnant women with severe PE (n=60). Blood samples were collected during antenatal care or at the time of admission, and the platelet indices were compared among the three groups...
April 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/23676885/preeclampsia-are-platelet-count-and-indices-useful-for-its-prognostic
#9
Letícia Gonçalves Freitas, Patrícia Nessralla Alpoim, Flávia Komatsuzaki, Maria das Graças Carvalho, Luci Maria S Dusse
INTRODUCTION: Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th week gestation. The aim of this study was to investigate whether platelet count (PC) and platelet indices (mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT)) could predict severe form of preeclampsia (sPE). METHODS: Three groups were evaluated; G1-pregnant with sPE (N = 29); G2-normotensive pregnant (N = 28) and Group 3: non-pregnant women (N = 30)...
November 2013: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/22617589/first-trimester-prediction-of-preeclampsia-in-nulliparous-women-at-low-risk
#10
MULTICENTER STUDY
Leslie Myatt, Rebecca G Clifton, James M Roberts, Catherine Y Spong, John C Hauth, Michael W Varner, John M Thorp, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Marshall W Carpenter, Jay D Iams, Anthony Sciscione, Margaret Harper, Jorge E Tolosa, George Saade, Yoram Sorokin, Garland D Anderson
OBJECTIVE: To identify clinical characteristics and biochemical markers in first-trimester samples that would possibly predict the subsequent development of preeclampsia. METHODS: We conducted a multicenter observational study in 2,434 nulliparous women at low risk to identify biomarkers that possibly predict preeclampsia. Clinical history, complete blood count, and biochemical markers were assessed in the first trimester. The trophoblast and angiogenesis markers ADAM-12, pregnancy-associated plasma protein-A, placental protein 13, placental growth factor, soluble fms-like tyrosine kinase-1, and endoglin were measured in a case-control subset of 174 women with preeclampsia and 509 women in the control group...
June 2012: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/20594474/-serum-soluble-endoglin-plasma-endothelin-1-and-coagulation-function-in-early-onset-severe-preeclampsia-with-organ-dysfunction
#11
Li-jun Zhang, Yu-huan Han, Yu-zhi Han
OBJECTIVE: To investigate the expression levels of serum soluble Endoglin (sEng), plasma endothelin-1 (ET-1) and coagulation function in patients suffering from early onset severe preeclampsia with organ dysfunction, and to analyze the clinical significance. METHODS: Forty-nine early onset severe preeclampsia patients were enrolled in the study group, including 26 cases without organ dysfunction (study group I) and 23 cases with organ dysfunction (study group II)...
June 2010: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
https://www.readbyqxmd.com/read/19557662/maternal-hemoglobin-concentration-and-its-association-with-birth-weight-in-newborns-of-mothers-with-preeclampsia
#12
Odül A Amburgey, Eliesa Ing, Gary J Badger, Ira M Bernstein
OBJECTIVE: Maternal hemoglobin concentration is inversely related to newborn size presumably through plasma volume constriction. We sought to determine whether birth weight would show an inverse relationship to hemoglobin concentration in a group of infants whose mothers had preeclampsia, where plasma volume constriction is common. METHODS: Electronic and paper chart review identified 142 nulliparous women with preeclampsia (excluding hemolysis, elevated liver enzymes, low platelets syndrome)...
September 2009: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/19490412/impact-of-delivery-mode-and-gestational-age-on-haematological-parameters-in-taiwanese-preterm-infants
#13
Jun-Ho Wu, Hung-Chieh Chou, Pau-Chung Chen, Suh-Fang Jeng, Chien-Yi Chen, Po-Nien Tsao, Chia-Jung Hsieh, Hsiu-Min Huang, Wu-Shiun Hsieh
AIM: Reference ranges of haematological parameters in preterm infants are limited. The aim of this study is to determine the reference values of haematological parameters in preterm infants in Taiwan, and to assess the impact of gestational age and mode of delivery on these parameters. METHOD: Medical records were retrospectively reviewed in preterm infants admitted to National Taiwan University Hospital from January 2001 to December 2004. The inclusion criteria included infants with <37 weeks of gestation who had blood sampling within 24 h of birth...
June 2009: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/15507197/the-prediction-of-adverse-maternal-outcomes-in-preeclampsia
#14
Peter von Dadelszen, Laura A Magee, Rajashree M Devarakonda, Trevor Hamilton, Laurie M Ainsworth, Ruihua Yin, Monica Norena, Keith R Walley, Andrée Gruslin, Jean-Marie Moutquin, Shoo K Lee, James A Russell
OBJECTIVES: (1) To evaluate whether clinical variables reflecting the multiorgan dysfunctions of preeclampsia can predict adverse maternal outcomes of preeclampsia; (2) to determine the usefulness of the mean platelet volume (MPV):platelet ratio as a novel measure of platelet consumption in predicting the severity of preeclampsia. METHOD: A retrospective chart review was conducted of cases of preeclampsia seen in 3 tertiary level units from January 2001 to December 2001...
October 2004: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/15121567/platelet-activation-sympathetic-tone-and-plasma-volume-in-nulligravid-women-of-reproductive-age
#15
Dana P Damron, Beth A Bouchard, Robert E Shapiro, Adrienne L Schonberg, Ira M Bernstein
OBJECTIVE: Preeclampsia is associated with increased platelet activation, increased sympathetic activity, and decreased plasma volume. We sought to estimate the relationship of plasma volume, sympathetic activity, or both to platelet activation in nonpregnant nulligravid women. METHODS: We studied 37 healthy nulligravid subjects during the follicular phase of the menstrual cycle. After intravenous access was obtained, subjects rested in the supine position for 15 minutes...
May 2004: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/14669395/-morphologic-parameters-of-blood-platelets-and-activity-na-h-nhe-1-exchanger-in-normal-pregnancy-and-pregnancy-complicated-with-preeclampsia
#16
Dariusz Adam Bielecki, Marian Tomasiak, Halina Stelmach, Małgorzata Hołub, Jan Urban
UNLABELLED: The aim of the study was the evaluation of number and morphologic parameters of blood platelets and sodium-proton platelet exchangers in pregnant women in the 3rd trimester of pregnancy, healthy (155) and with preeclampsia (40). RESULTS: Blood platelet number was significantly lower in patients with preeclampsia than in healthy subjects (195,000 vs 222,000). Mean platelet volume was significantly higher in patients with preeclampsia (9.5 fl vs 8.6 fl)...
October 2003: Ginekologia Polska
https://www.readbyqxmd.com/read/10577615/late-onset-postpartum-thrombocytosis-in-preeclampsia
#17
B Aune, K Gjesdal, P Oian
BACKGROUND: During pregnancy, changes in blood coagulation and fibrinolysis create a hypercoagulable state. In the puerperium this thrombogenicity is even higher, and the chance of developing thromboembolism is 3-5 times higher in this period than during pregnancy. In preeclampsia, platelets are activated and play a substantial role in the pathogenesis of the disease. Systematic information on longitudinal changes in platelet number and size postpartum after normotensive and preeclamptic pregnancies is not available...
November 1999: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/10086090/-preeclampsia-not-yet-predictable-from-the-blood-platelet-count
#18
REVIEW
R Lazarov, A Konijnenberg, J A van der Post, A Sturk, K Boer
Platelet activation plays an important role in the pathogenesis of pre-eclampsia as demonstrated by reduced platelet count, increased mean platelet volume and elevated plasma concentrations of beta-thromboglobulin and platelet factor 4 in pre-eclamptic patients. Thrombocytopenia precedes the onset of clinical symptoms of pre-eclampsia. Possibly an enhanced activation state of the platelets in the circulation is present some time before the onset of pre-eclampsia: platelet activation might then be used to predict pre-eclampsia...
January 2, 1999: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/9646948/a-prospective-longitudinal-study-of-platelet-angiotensin-ii-receptors-for-the-prediction-of-preeclampsia
#19
J Massé, J C Forest, J M Moutquin, P Degrandpré, V I Forest
OBJECTIVES: We developed a simplified method using a relatively small volume of blood for the determination of platelet angiotensin II receptors by saturation analysis and we evaluated its performance for the prediction of preeclampsia. DESIGN AND METHODS: A platelet suspension with minimal contamination by leukocytes and erythrocytes is obtained by centrifugation and washing. The platelet concentrate is incubated in a multi-well plate with increasing concentration of radiolabelled angiotensin II in the presence or absence of an excess of unlabelled angiotensin II...
June 1998: Clinical Biochemistry
https://www.readbyqxmd.com/read/9569185/titration-of-antiplatelet-treatment-in-pregnant-women-at-risk-of-preeclampsia
#20
M H Sullivan, N A Clark, M de Swiet, C Nelson-Piercy, M G Elder
We recruited 111 patients who were considered to be at significantly increased risk of preeclampsia on the basis of previous obstetric history or preexisting medical disorders. All patients were treated with low dose aspirin (75 mg/day) from the first occasion the patient attended the antenatal clinic, regardless of gestational age. If the maternal mean platelet volume (MPV) increased significantly (by > 0.8 fl) from the baseline, antiplatelet treatment was increased. Five pregnancies were lost during the second trimester and 106 of the treated patients had live infants...
April 1998: Thrombosis and Haemostasis
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