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https://www.readbyqxmd.com/read/28938249/absence-of-fitness-improvement-is-associated-with-outcomes-in-heart-failure-patients
#1
Esmée A Bakker, Johan A Snoek, Esther P Meindersma, Maria T E Hopman, Louise Bellersen, André L M Verbeek, Dick H J Thijssen, Thijs M H Eijsvogels
PURPOSE: To examine the clinical impact of cardiorespiratory fitness (CRF) and improvements in CRF after cardiac rehabilitation (CR) in heart failure (HF) patients for their risk of all-cause mortality and unplanned hospitalization. Secondly, to investigate possible factors associated with the absence of improvement in CRF after rehabilitation. METHODS: We included 155 HF patients receiving CR between October 2009 and January 2015. Patients performed an incremental bicycle test to assess CRF through peak oxygen uptake (VO2-peak) before and after CR-based supervised exercise training...
September 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28936999/non-adherence-to-cml-therapy-and-its-clinical-implications-in-india
#2
REVIEW
Hari Menon
Clinical trials have shown that early and deeper cytogenetic/ molecular responses to tyrosine kinase inhibitors (TKIs) help in achieving improved long-term outcomes including lower rates of disease progression in chronic myeloid leukaemia (CML). However, the level of molecular responses achieved with TKI therapy in patients with CML is variable and this could be explained by differences in adherence to CML therapy. A systematic literature review of CML studies reporting adherence to BCR-ABL inhibitors from the USA, Asia and Europe (19 articles: 9 retrospective, 4 prospective, rest cross-sectional) showed that average adherence varies from 19% to 100% of the proportion of prescribed drug taken...
May 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28936751/guidelines-versus-real-life-practice-the-case-of-colonoscopy-in-acromegaly
#3
M Parolin, F Dassie, L Russo, S Mazzocut, M Ferrata, E De Carlo, R Mioni, F Fallo, R Vettor, C Martini, P Maffei
PURPOSE: The aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly. METHODS: We conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values. RESULTS: The total number of colonoscopies performed in ACRO patients increased from 6 in the period 1990-1994 to 57 in the period 2010-2014...
September 21, 2017: Pituitary
https://www.readbyqxmd.com/read/28936414/the-health-benefits-and-constraints-of-exercise-therapy-for-wheelchair-users-a-clinical-commentary
#4
Terry J Ellapen, Henriëtte V Hammill, Mariette Swanepoel, Gert L Strydom
BACKGROUND: There are approximately 1 billion people living with chronic lower limb disability, many of whom are wheelchair users. OBJECTIVES: Review cardiometabolic and neuromuscular risk profiles of wheelchair users, benefits of regular exercise and the causes of neuromuscular upper limb and hip injuries that hinder regular adherence. METHOD: Literature published between 2013 and 2017 was adopted according to the standard practices for systematic reviews (PRISMA) through Crossref Metadata and Google Scholar searches...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28936226/challenges-in-modeling-complexity-of-neglected-tropical-diseases-a-review-of-dynamics-of-visceral-leishmaniasis-in-resource-limited-settings
#5
REVIEW
Swati DebRoy, Olivia Prosper, Austin Mishoe, Anuj Mubayi
OBJECTIVES: Neglected tropical diseases (NTD), account for a large proportion of the global disease burden, and their control faces several challenges including diminishing human and financial resources for those distressed from such diseases. Visceral leishmaniasis (VL), the second-largest parasitic killer (after malaria) and an NTD affects poor populations and causes considerable cost to the affected individuals. Mathematical models can serve as a critical and cost-effective tool for understanding VL dynamics, however, complex array of socio-economic factors affecting its dynamics need to be identified and appropriately incorporated within a dynamical modeling framework...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28936151/adherence-to-oral-hypoglycemic-medication-among-patients-with-diabetes-in-saudi-arabia
#6
Nahid Osman Ahmed, Salwa Abugalambo, Ghadeer Hamad Almethen
INTRODUCTION: Diabetes mellitus is a chronic progressive disease characterized by numerous health complications. Medication adherence is an important determinant of therapeutic outcome. The objective of this study was to assess hypoglycemic medication adherence. MATERIALS AND METHODS: This is a descriptive cross-sectional web-based study. The eight-item Morisky medication adherence scale was used to assess adherence. RESULTS: A convenience sample of 290 patients with diabetes was studied; of them, 10...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28936146/adherence-to-clinical-practice-guidelines-for-the-treatment-of-candidemia-at-a-veterans-affairs-medical-center
#7
Chester N Ashong, Andrew S Hunter, M David Mansouri, Richard M Cadle, Richard J Hamill, Daniel M Musher
OBJECTIVES: The primary objective of this study was to examine the appropriateness of candidemia management at a Veterans Affairs Medical Center as recommended by the 2009 Infectious Diseases Society of America (IDSA) guidelines for treatment of Candida infections. METHODS: A retrospective analysis of 94 adult patients with blood cultures positive for Candida spp. was performed. Patients were stratified by severity of disease into two groups: non-neutropenic, mild-moderate disease (Group 1, n = 54, 56%) and non-neutropenic, moderate-severe disease (Group 2, n = 40, 42%)...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28934624/gamification-of-medication-adherence-in-epilepsy
#8
REVIEW
Mohammad Izzat Abdul Rahim, Rhys Huw Thomas
Adherence to medication regimens is a crucial factor in seizure-freedom and well-being for people with epilepsy. In contrast, taking medication inconsistently increases the risk of not only seizures and their adverse effects, but drug side-effects and unnecessary modifications to treatment plans. Epilepsy is prevalent across all age groups and we have been slow to utilise both the technologies and psychologies derived from computer gaming. Gaming has broken through to the mainstream and is no longer the preserve of younger males, mirroring the adoption of smart-phones...
September 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28932539/optimal-cut-off-value-and-clinical-usefulness-of-the-adherence-starts-with-knowledge-12-in-patients-with-asthma-taking-inhaled-corticosteroids
#9
Masaya Takemura, Masayuki Nishio, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Takamitsu Asano, Hiroki Tomita, Yoshihiro Kanemitsu, Kosho Yoshikawa, Akio Niimi
BACKGROUND: Non-adherence to inhalation regimens is common in asthmatic patients. The Adherence Starts with Knowledge-12 (ASK-12) survey was developed to detect and address patient-specific barriers to medication adherence. Our objective is to investigate the clinical usefulness of the ASK-12 for assessing and addressing adherence to inhalation therapy in asthma. METHODS: The ASK-12 was administered to 138 asthmatic patients. Using pharmacy-refill data, we examined the cut-off value of the ASK-12 to identify patients who were non-adherent to inhalation regimens and identify factors associated with non-adherence...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932106/out-of-pocket-costs-and-adherence-to-antihypertensive-agents-among-older-adults-covered-by-the-public-drug-insurance-plan-in-quebec
#10
Raymond Milan, Helen-Maria Vasiliadis, Samantha Gontijo Guerra, Djamal Berbiche
OBJECTIVE: To evaluate the effect of patient out-of-pocket costs on adherence to antihypertensive agents (AHA) in community-dwelling older adults covered by the public drug insurance plan in Quebec. METHODS: This is a secondary analysis of data from the "Étude sur la santé des aînés" study (2005-2008) on community-dwelling older adults in Quebec aged 65 years and older (N=2,811). The final sample included 881 participants diagnosed with arterial hypertension and treated with AHA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28931699/adoption-of-telehealth-remote-biometric-monitoring-among-peritoneal-dialysis-patients-in-the-united-states
#11
Susie Q Lew, Neal Sikka, Clinton Thompson, Teena Cherian, Manya Magnus
We examined participant uptake and utilization of remote monitoring devices, and the relationship between remote biometric monitoring (RBM) of weight (Wt) and blood pressure (BP) with self-monitoring requirements. Participants on peritoneal dialysis (PD) (n = 269) participated in a Telehealth pilot study of which 253 used remote monitoring of BP and 255 for Wt. Blood pressure and Wt readings were transmitted in real time to a Telehealth call center, which were then forwarded to the PD nurses for real-time review...
September 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28931567/sex-differences-in-risk-factor-management-of-coronary-heart-disease-across-three-regions
#12
Min Zhao, Ilonca Vaartjes, Ian Graham, Diederick Grobbee, Wilko Spiering, Kerstin Klipstein-Grobusch, Mark Woodward, Sanne Ae Peters
OBJECTIVE: To investigate whether there are sex differences in risk factor management of patients with established coronary heart disease (CHD), and to assess demographic variations of any potential sex differences. METHODS: Patients with CHD were recruited from Europe, Asia, and the Middle East between 2012-2013. Adherence to guideline-recommended treatment and lifestyle targets was assessed and summarised as a Cardiovascular Health Index Score (CHIS). Age-adjusted regression models were used to estimate odds ratios for women versus men in risk factor management...
September 20, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28931456/perceptions-of-barriers-to-the-management-of-respiratory-tract-infections-in-general-practice-settings-in-australia
#13
Stephanie Fletcher-Lartey, Rabia Khan
Inappropriate prescribing of antibiotics for the management of respiratory tract infections (RTIs) has contributed to increased prevalence of antibiotic resistance, and this remains a challenge. The aim of this study was to evaluate the effect of general practitioners' (GPs) participation in the Antibiotics: Clinical e-Audit, a quality-improvement activity, on GP self-reported knowledge and practice change, and explored barriers encountered in the management of respiratory tract infections (RTIs). Participants completed a survey at the end of the activity to assess the usefulness of the audit, any reported changes made and barriers encountered to their clinical practice...
September 21, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28930165/timeliness-of-childhood-primary-immunization-and-risk-factors-related-with-delays-evidence-from-the-2014-zhejiang-provincial-vaccination-coverage-survey
#14
Yu Hu, Qian Li, Yaping Chen
Background: this study aimed to assess both immunization coverage and timeliness, as well as reasons for non-vaccination, and identity the risk factors of delayed immunization, for the vaccines scheduled during the first year of life, in Zhejiang province, east China. Methods: A cluster survey among children aged 24-35 months was conducted. Demographic information and socio-economic characteristics of the selected child, the mother, and the household were collected. Immunization data were transcribed from immunization cards...
September 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28930059/the-role-of-alcohol-on-antiretroviral-therapy-adherence-among-persons-living-with-hiv-in-urban-india
#15
Stephen L Schensul, Toan Ha, Jean J Schensul, Melita Vaz, Rajendra Singh, Joseph A Burleson, Kendall Bryant
OBJECTIVE: The purpose of this study was to estimate the prevalence of alcohol use among men living with HIV on antiretroviral therapy (ART) and examine the association of alcohol use and psychosocial variables on ART adherence. The study was a cross-sectional survey supplemented by medical records and qualitative narratives as a part of the initial formative stage of a multilevel, multicentric intervention and evaluation project. METHOD: A screening instrument was administered to men living with HIV (n = 3,088) at four ART Centers using the Alcohol Use Disorders Identification Test-consumption questions (AUDIT-C) to determine alcohol use for study eligibility...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28928177/adherence-and-dosing-interval-of-subcutaneous-antitumour-necrosis-factor-biologics-among-patients-with-inflammatory-arthritis-analysis-from-a-canadian-administrative-database
#16
Peter Bhoi, Louis Bessette, Mary J Bell, Cathy Tkaczyk, Francois Nantel, Karina Maslova
OBJECTIVES: Subcutaneous tumour necrosis factor alpha TNFαinhibitors (SC-TNFis) such as golimumab (GLM), adalimumab (ADA), etanercept (ETA) and certolizumab pegol (CZP) have been used for many years for the treatment of inflammatory arthritis. Non-adherence to therapy is an important modifiable factor that may compromise patient outcomes. The aim of this analysis was to compare adherence and dosing interval of SC-TNFis in the treatment of people with inflammatory arthritis. DESIGN: We used the IMS Brogan database combining both Canadian private and public drug plan databases of Ontario and Quebec...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28926636/the-expected-and-unexpected-benefits-of-dispensing-the-exact-number-of-pills
#17
Carole Treibich, Sabine Lescher, Luis Sagaon-Teyssier, Bruno Ventelou
BACKGROUND: From November 2014 to November 2015, an experiment in French community pharmacies replaced traditional pre-packed boxes by per-unit dispensing of pills in the exact numbers prescribed, for 14 antibiotics. METHODS: A cluster randomised control trial was carried out in 100 pharmacies. 75 pharmacies counted out the medication by units (experimental group), the other 25 providing the treatment in the existing pharmaceutical company boxes (control group)...
2017: PloS One
https://www.readbyqxmd.com/read/28925959/preventing-surgical-site-infections-using-a-natural-biodegradable-antibacterial-coating-on-surgical-sutures
#18
Jochen Reinbold, Ann-Kristin Uhde, Ingrid Müller, Tobias Weindl, Jürgen Geis-Gerstorfer, Christian Schlensak, Hans-Peter Wendel, Stefanie Krajewski
Surgical site infections (SSIs) are one of the most common nosocomial infections, which can result in serious complications after surgical interventions. Foreign materials such as implants or surgical sutures are optimal surfaces for the adherence of bacteria and subsequent colonization and biofilm formation. Due to a significant increase in antibiotic-resistant bacterial strains, naturally occurring agents exhibiting antibacterial properties have great potential in prophylactic therapies. The aim of this study was to develop a coating for surgical sutures consisting of the antibacterial substance totarol, a naturally occurring diterpenoid isolated from Podocarpustotara in combination with poly(lactide-co-glycolide acid) (PLGA) as a biodegradable drug delivery system...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925586/haemopref-further-evaluation-of-patient-perception-and-preference-for-treatment-in-a-real-world-setting
#19
S Bonanad, M Schulz, A Gordo, D Spurden, M Cicchetti, J C Cappelleri, C Tolley, H Staunton, E Brohan
INTRODUCTION: Adherence to haemophilia A (HA) treatment may be influenced by patients' beliefs about their condition and treatment. Furthermore, difficulties administering treatment may lead to poor adherence. New treatment strategies aim to reduce the burden associated with administration and to improve patient perception of treatment, which, in turn, increase adherence levels. AIMS: This study aimed to examine patient perception of HA treatment and related factors using patient-reported outcome (PRO) questionnaires and to confirm the psychometric properties of a recently developed questionnaire, the HaemoPREF...
September 19, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28925027/a-prospective-international-study-on-adherence-to-treatment-in-305-patients-with-flaring-sle-assessment-by-drug-levels-and-by-self-administered-questionnaires
#20
Nathalie Costedoat-Chalumeau, Frédéric Houssiau, Peter Izmirly, Véronique Le Guern, Sandra Navarra, Meenakshi Jolly, Guillermo Ruiz-Irastorza, Gabriel Baron, Eric Hachulla, Nancy Agmon-Levin, Yehuda Shoenfeld, Francesca Dall'Ara, Jill Buyon, Christophe Deligny, Ricard Cervera, Estibaliz Lazaro, Holy Bezanahary, Gaëlle Leroux, Nathalie Morel, Jean-François Viallard, Christian Pineau, Lionel Galicier, Ronald Van Vollenhoven, Angela Tincani, Hanh Nguyen, Guillaume Gondran, Noel Zahr, Jacques Pouchot, Jean-Charles Piette, Michelle Petri, David Isenberg
Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half-life and can be quantified by HPLC. This international study evaluated nonadherence in 305 lupus patients with flares using drug levels (HCQ<200ng/ml or undetectable desethylchloroquine), and self-administered questionnaires (MASRI<80% or MMAS-8<6). Drug levels defined 18.4% of the patients as severely nonadherent. In multivariate analyses, younger age, non-use of steroids, higher BMI and unemployment were associated with nonadherence by drug level...
September 19, 2017: Clinical Pharmacology and Therapeutics
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