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https://www.readbyqxmd.com/read/28749622/understanding-and-challenges-in-taking-tyrosine-kinase-inhibitors-among-malaysian-chronic-myeloid-leukemia-patients-a-qualitative-study
#1
Yik Ming Lim, Wei Lerk Eng, Huan Keat Chan
Background: In Malaysia, the treatment for chronic myeloid leukemia (CML) has long been delivered under the Malaysian Patient Assistance Program (MYPAP), but research on identifying factors contributing to non-adherence to tyrosine kinase inhibitors (TKIs) is still limited. The current study explored understanding and challenges of Malaysian CML patients in taking imatinib and nilotinib. Methods: Semi-structured, face-to-face interviews were conducted with 13 CML patients receiving treatment at a public tertiary care center, and were analyzed using the content analysis approach...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749527/relationship-between-alcohol-consumption-whether-linked-to-other-substance-use-or-not-and-antiretroviral-treatment-adherence-in-hiv-patients
#2
Sara González-Álvarez, Agustín Madoz-Gúrpide, Carlos Parro-Torres, Daniel Hernández-Huerta, Enriqueta Ochoa Mangado
Hazardous alcohol consumption is a common diagnosis among people living with HIV infection. The relationship between alcohol consumption and poor adherence to antiretroviral therapy has been highlighted in different studies, yet few of them performed a parallel analysis of other substance use. In Spain, alcohol consumption is frequently associated with other substance use, mainly cannabis and cocaine. The aim of this study is to assess the influence of hazardous alcohol consumption both combined with other substances (cocaine, heroin, methadone and/or cannabis) or alone on antiretroviral therapy adherence in our social environment...
July 14, 2017: Adicciones
https://www.readbyqxmd.com/read/28749402/coverage-of-childhood-vaccination-among-children-aged-12-23-months-tamil-nadu-2015-india
#3
Manoj V Murhekar, P Kamaraj, K Kanagasabai, G Elavarasu, T Daniel Rajasekar, K Boopathi, Sanjay Mehendale
BACKGROUND & OBJECTIVES: District-Level Household Survey-4 (DLHS-4) indicated that during 2012-2013, only 56 per cent of children aged 12-23 months in Tamil Nadu were fully vaccinated, which were lesser than those reported in earlier national surveys. We, therefore, conducted cluster surveys to estimate coverage of childhood vaccination in the State, and also to identify the factors associated with low coverage. METHODS: Cross-sectional surveys were conducted in 15 strata [municipal corporation non-slum (n=1), municipal corporation slum (n=1), hilly (n=1), rural (n=6) and urban (n=6)]...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28748443/adherence-to-guidelines-for-adult-non-gist-soft-tissue-sarcoma-in-the-netherlands-a-plea-for-dedicated-sarcoma-centers
#4
Harald J Hoekstra, Rick L M Haas, Cornelis Verhoef, Albert J H Suurmeijer, Carla S P van Rijswijk, Ben G H Bongers, Winette T van der Graaf, Vincent K Y Ho
INTRODUCTION: Optimal management of soft tissue sarcoma (STS) remains a challenge. A nationwide survey assessed the quality of STS care in the Netherlands, thereby aiming to identify potentialities for improvement through more centralized disease management. METHODS: From the Netherlands Cancer Registry (NCR), data were obtained on 3317 adult STS patients (excluding gastrointestinal stromal tumor, GIST) diagnosed in 2006-2011. Logistic regression models were employed to compare outcomes on selected clinical indicators reflecting prevailing STS guidelines between high-volume (≥10 resections annually) and low-volume (<10 resections) hospitals, between academic and general hospitals, and between sarcoma research centers and other hospitals, adjusted for case mix...
July 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28748108/readyspeech-for-people-with-dysarthria-after-stroke-protocol-for-a-feasibility-randomised-controlled-trial
#5
Claire Mitchell, Audrey Bowen, Sarah Tyson, Paul Conroy
BACKGROUND: Dysarthria, a disordered speech production resulting from neuro-muscular impairment, is a common symptom after stroke. It causes significant problems for patients' speech intelligibility, communication, psychological well-being, social engagement and stroke recovery. Rehabilitation for dysarthria is variable in quality, intensity and duration, which may be, in part, due to the lack of good quality evidence. An online therapy programme, ReaDySpeech, has the potential to improve quality, intensity and duration of speech rehabilitation and was considered in a proof-of-concept study to be acceptable to speech and language therapists and patients which warranted further evaluation...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28748003/patient-attitudes-towards-community-based-tuberculosis-dot-and-adherence-to-treatment-in-an-urban-setting-kampala-uganda
#6
Sempeera Hassard, Anguzu Ronald, Kawooya Angella
INTRODUCTION: High Tuberculosis treatment default rate (17%) and sub-optimal treatment completion rates (45%) has burdened Kampala. Nevertheless, there are observable increase in the number of patients on TB DOT; from 6% to 29% in two consecutive annual reports. The main objective was to determine the association of TB patient attitudes towards community-based observers on the TB drug adherence on directly observed treatment for TB in Kampala. METHODS: A cross-sectional study was carried out in Lubaga division, Kampala...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28743270/pre-transplant-depression-as-a-predictor-of-adherence-and-morbidities-after-orthotopic-heart-transplantation
#7
Maja Delibasic, Burhan Mohamedali, Nikola Dobrilovic, Jaishankar Raman
BACKGROUND: Psychosocial factors are useful predictors of adverse outcomes after solid organ transplantation. Although depression is a known predictor of poor outcomes in patients who undergo orthotopic heart transplantation (OHT) and is actively screened for during pre-transplant evaluation, the effects of early identification of this entity on post-transplant outcomes are not clearly understood. The purpose of this study was to evaluate the impact of pre-transplant depression on outcomes after OHT...
July 25, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28743254/association-between-serotonin-transporter-gene-polymorphisms-and-increased-suicidal-risk-among-hiv-positive-patients-in-uganda
#8
Allan Kalungi, Soraya Seedat, Sian M J Hemmings, Lize van der Merwe, Moses L Joloba, Ann Nanteza, Noeline Nakassujja, Harriet Birabwa, Jennifer Serwanga, Pontiano Kaleebu, Eugene Kinyanda
BACKGROUND: Persons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and poor adherence with antiretroviral therapy. Clinical risk factors have low predictive value for suicide, hence the interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. The serotonin transporter gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected study populations and its variations may provide a platform for identifying genetic risk for suicidality among PLWHA...
July 25, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28743251/acceptability-of-lifelong-treatment-among-hiv-positive-pregnant-and-breastfeeding-women-option-b-in-selected-health-facilities-in-zimbabwe-a-qualitative-study
#9
Addmore Chadambuka, Leila Katirayi, Auxilia Muchedzi, Esther Tumbare, Reuben Musarandega, Agnes I Mahomva, Godfrey Woelk
BACKGROUND: Zimbabwe's Ministry of Health and Child Care (MOHCC) adopted 2013 World Health Organization (WHO) prevention of mother-to-child HIV transmission (PMTCT) guidelines recommending initiation of HIV-positive pregnant and breastfeeding women (PPBW) on lifelong antiretroviral treatment (ART) irrespective of clinical stage (Option B+). Option B+ was officially launched in Zimbabwe in November 2013; however the acceptability of life-long ART and its potential uptake among women was not known...
July 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28743244/non-adherence-to-medication-regimens-among-older-african-american-adults
#10
Mohsen Bazargan, James Smith, Hamed Yazdanshenas, Masoud Movassaghi, David Martins, Gail Orum
BACKGROUND: Despite concerns about racial differences on adherence to prescribed medication rigimens among older adults, current information about nonadherence among underserved elderly African Americans with co-morbidities is limited. This study examines the association between adherence to drug regimens and an array of medication-related factors, including polypharmacy, medication regimen complexity, use of Potentially Inappropriate Medications (PIM), and knowledge about the therapeutic purpose and instructions of medication use...
July 25, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28742913/the-effect-of-nursing-quality-improvement-and-mobile-health-interventions-on-infant-sleep-practices-a-randomized-clinical-trial
#11
Rachel Y Moon, Fern R Hauck, Eve R Colson, Ann L Kellams, Nicole L Geller, Timothy Heeren, Stephen M Kerr, Emily E Drake, Kawai Tanabe, Mary McClain, Michael J Corwin
Importance: Inadequate adherence to recommendations known to reduce the risk of sudden unexpected infant death has contributed to a slowing in the decline of these deaths. Objective: To assess the effectiveness of 2 interventions separately and combined to promote infant safe sleep practices compared with control interventions. Design, Setting, and Participants: Four-group cluster randomized clinical trial of mothers of healthy term newborns who were recruited between March 2015 and May 2016 at 16 US hospitals with more than 100 births annually...
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28742820/facilitators-and-barriers-to-physical-activity-in-people-with-chronic-low-back-pain-a-qualitative-study
#12
Laura Boutevillain, Arnaud Dupeyron, Caroline Rouch, Emilie Richard, Emmanuel Coudeyre
BACKGROUND: For medical teams, one of the main objectives of rehabilitation for people with chronic low back pain is adherence to physical activity (PA). OBJECTIVE: The objective of this study was to identify PA barriers and facilitators in this population. METHODS: This qualitative study included 4 discussion groups and 16 semi-structured interviews conducted among people with non-specific chronic low back pain who were involved in a specific rehabilitation program or seen in primary care settings...
2017: PloS One
https://www.readbyqxmd.com/read/28741176/safety-and-feasibility-of-exercise-interventions-in-patients-with-advanced-cancer-a-systematic-review
#13
REVIEW
Reginald Heywood, Alexandra L McCarthy, Tina L Skinner
GOALS OF WORK: The beneficial effects of exercise in cancer patients are reasonably well-established, although research in this field has predominantly investigated cancer patients in the earlier stages of disease. However, the most recent evidence surrounding exercise interventions in advanced cancer populations has yet to be systematically evaluated. This review critically analyses the safety and feasibility of exercise interventions in patients with advanced cancer. METHODS: All randomised, non-randomised and prospective observational trials of exercise training interventions in patients with advanced cancer were included...
July 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28741122/adherence-to-national-comprehensive-cancer-network-guidelines-is-associated-with-improved-survival-for-patients-with-stage-2a-and-stages-2b-and-3-extremity-and-superficial-trunk-soft-tissue-sarcoma
#14
Rachel K Voss, Yi-Ju Chiang, Keila E Torres, B Ashleigh Guadagnolo, Gary N Mann, Barry W Feig, Janice N Cormier, Christina L Roland
BACKGROUND: The National Comprehensive Cancer Network (NCCN) has instituted treatment guidelines for stage 2A and stages 2B and 3 extremity and superficial trunk soft tissue sarcomas (ETSTS). This study examined adherence to the NCCN guidelines and factors associated with nonadherent treatment and survival outcomes. METHODS: Patients with stage 2A and stages 2B and 3 ETSTS (n = 15,957) were categorized as undergoing adherent or nonadherent treatment based on the 2014 NCCN guidelines...
July 24, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28741090/direct-comparison-of-tadalafil-with-sildenafil-for-the-treatment-of-erectile-dysfunction-a-systematic-review-and-meta-analysis
#15
Binbin Gong, Ming Ma, Wenjie Xie, Xiaorong Yang, Yongming Huang, Ting Sun, Yanping Luo, Jiao Huang
AIMS: Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED. METHODS: We designed a strategy for searching the PubMed, Embase, EBSCO, Web of Science and Cochrane library databases; the reference lists of the retrieved studies were also investigated...
July 24, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28740368/impact-of-adherence-to-biological-agents-on-health-care-resource-utilization-for-patients-over-the-age-of-65-years-with-rheumatoid-arthritis
#16
Urja Lathia, Emmanuel M Ewara, Francois Nantel
OBJECTIVE: Poor adherence to therapy increases the patient and societal burden and complexity of chronic diseases such as rheumatoid arthritis (RA). In the past 15 years, biologic disease-modifying anti-rheumatic drugs (DMARDs) have revolutionized the treatment of RA. However, little data are available on the impact of adherence to biologics on health care resources. The objective of the study was to determine the long-term health care resource utilization patterns of RA patients who were adherent to biologic DMARD therapy compared to RA patients who were non-adherent to biologic DMARD therapy in an Ontario population and to determine factors influencing adherence...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28738259/reasons-associated-with-treatment-non-adherence-in-schizophrenia-in-a-pakistan-cohort
#17
Irshad Ahmad, Muhammad Tahir Khalily, Brian Hallahan
non-adherence in patients with schizophrenia is the most common reason for a relapse of psychosis. In a cohort of participants in Pakistan who suffered a relapse of psychosis, we aimed to identify the principal factors associated with non-adherence, including any culture specific factors that might not be as significant in other jurisdictions. Semi-structured interviews were undertaken at four psychiatric hospitals in the Peshawar region in Pakistan with 55 participants (44 male and 11 female) diagnosed with schizophrenia, who had suffered a relapse of psychosis subsequent to treatment non-adherence...
July 13, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28738199/acute-ecotoxicity-of-coated-colloidal-goethite-nanoparticles-on-daphnia-magna-evaluating-the-influence-of-exposure-approaches
#18
V González-Andrés, M Diez-Ortiz, C Delpivo, G Janer, A Fritzsche, S Vázquez-Campos
Synthesized iron oxide nanoparticles have been proposed as an alternative to non-dispersed iron oxides for in situ environmental remediation. Their colloidal properties enable their injection into porous media, i.e. soils and aquifers, and offer a higher efficiency in removing contaminants. However, this dispersed state is also the cause of concerns over their environmental fate and toxicity, e.g., by increasing the exposure time to aquatic organisms in groundwater remediation activities. Therefore, the objective of in situ groundwater remediation is to establish local reactive barriers in the subsurface by injection by means of reactive colloids with a controllable mobility under in situ conditions and present as colloids as shortly as possible...
July 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28737994/impact-of-a-patient-support-program-on-patient-adherence-to-adalimumab-and-direct-medical-costs-in-crohn-s-disease-ulcerative-colitis-rheumatoid-arthritis-psoriasis-psoriatic-arthritis-and-ankylosing-spondylitis
#19
David T Rubin, Manish Mittal, Matthew Davis, Scott Johnson, Jingdong Chao, Martha Skup
BACKGROUND: AbbVie provides a free-to-patient patient support program (PSP) to assist adalimumab-treated patients with medication costs, nurse support, injection training, pen disposal, and medication reminders. The impact of these services on patient adherence to adalimumab and direct medical costs associated with autoimmune disease has not been assessed. OBJECTIVE: To quantify the relationship between participation in a PSP and outcomes (adalimumab adherence, persistence, and direct medical costs) in patients initiating adalimumab treatment...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737986/real-world-adherence-and-persistence-to-oral-disease-modifying-therapies-in-multiple-sclerosis-patients-over-1-year
#20
Kristen M Johnson, Huanxue Zhou, Feng Lin, John J Ko, Vivian Herrera
BACKGROUND: Disease-modifying therapies (DMTs) are indicated to reduce relapse rates and slow disease progression for relapsing-remitting multiple sclerosis (MS) patients when taken as prescribed. Nonadherence or non-persistence in the real-world setting can lead to greater risk for negative clinical outcomes. Although previous research has demonstrated greater adherence and persistence to oral DMTs compared with injectable DMTs, comparisons among oral DMTs are lacking. OBJECTIVE: To compare adherence, persistence, and time to discontinuation among MS patients newly prescribed the oral DMTs fingolimod, dimethyl fumarate, or teriflunomide...
August 2017: Journal of Managed Care & Specialty Pharmacy
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