keyword
https://read.qxmd.com/read/38489942/a-spatial-autocorrelation-analysis-of-road-traffic-crash-by-severity-using-moran-s-i-spatial-statistics-a-comparative-study-of-addis-ababa-and-berlin-cities
#21
JOURNAL ARTICLE
Wondwossen Taddesse Gedamu, Uwe Plank-Wiedenbeck, Bikila Teklu Wodajo
Methodological advancements in road safety research reveal an increasing inclination toward integrating spatial approaches in hot spot identification, spatial pattern analysis, and developing spatially lagged models. Previous studies on hot spot identification and spatial pattern analysis have overlooked crash severities and the spatial autocorrelation of crashes by severity, missing valuable insights into crash patterns and underlying factors. This study investigates the spatial autocorrelation of crash severity by taking two capital cities, Addis Ababa and Berlin, as a case study and compares patterns in low and high-income countries...
March 14, 2024: Accident; Analysis and Prevention
https://read.qxmd.com/read/38489818/comparison-of-multilevel-low-grade-techniques-versus-three-column-osteotomies-in-adult-spinal-deformity-surgery-does-harmonious-correction-matter
#22
JOURNAL ARTICLE
Peter G Passias, Tyler K Williamson, Jamshaid M Mir, Jordan A Lebovic, Pooja Dave, Peter S Tretiakov, Rachel Joujon-Roche, Bailey Imbo, Oscar Krol, Stephane Owusu-Sarpong, Shaleen Vira, Andrew J Schoenfeld, Alan H Daniels, Bassel G Diebo, Renaud Lafage, Virginie Lafage
OBJECTIVE: Recent debate has arisen between whether to use a three-column osteotomy (3CO) or multilevel low-grade (MLG) techniques to treat severe sagittal malalignment in adult spinal deformity (ASD) surgery. The goal of this study was to compare the outcomes of 3CO and MLG techniques performed in corrective surgeries for ASD. METHODS: ASD patients who had a baseline PI-LL > 30° and 2-year follow-up data were included. Patients underwent either 3CO or MLG (thoracolumbar posterior column osteotomies at ≥ 3 levels or anterior lumbar interbody fusion at ≥ 3 levels with no 3CO)...
March 15, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38487516/vascular-resistance-index-and-the-immediate-hemodynamic-success-of-lower-limb-distal-artery-revascularization
#23
JOURNAL ARTICLE
Rebecca Paes de Andrade Souza Caldas, Esdras Marques Lins, Gabriela de Oliveira Buril, Fernanda Appolônio Rocha, Emmanuelle Tenório Albuquerque Godoi Berenguer de Barros E Silva, Larissa Barbosa de Andrade, Camilla Lins da Cunha Cavalcanti, Guilherme Barros Alves de Carvalho
BACKGROUND: Revascularization surgery is used to attempt to restore blood flow to the foot in patients with critical ischemia (CI) caused by peripheral arterial occlusive disease of the lower limbs (LL). Ultrasonography with Doppler (USD) SAH emerged in recent years as a highly valuable method for planning this surgical intervention. OBJECTIVES: To evaluate the relationship between the resistance index (RI), measured with USD, and immediate hemodynamic success of LL revascularization surgery in patients with CI...
2024: Jornal Vascular Brasileiro
https://read.qxmd.com/read/38487168/phyto-pharmacological-evaluation-and-characterization-of-the-methanolic-extract-of-the-baccaurea-motleyana-m%C3%A3-ll-arg-seed-promising-insights-into-its-therapeutic-uses
#24
JOURNAL ARTICLE
Suriya Akter Shompa, Hasin Hasnat, Saima Jahan Riti, Md Mirazul Islam, Farjahan Nur, Safaet Alam, Chuxiao Shao, Shuanghu Wang, Peiwu Geng, Abdullah Al Mamun
Introduction: Plants and their extracts have been integral to the development of medicinal treatments throughout history, offering a vast array of compounds for innovative therapies. Baccaurea motleyana Müll. Arg., commonly known as Rambai, is an evergreen tree with economic importance in the Old-World Tropics. Method: The study investigates its phytochemical composition through Gas Chromatography-Mass Spectrometry (GC-MS) and evaluates its pharmacological properties, including antidiabetic, antidiarrheal, antimicrobial, and antidepressant effects...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38484920/macrophage-immunophenotypes-in-jorge-lobo-s-disease-and-lepromatous-leprosy-a-comparative-study
#25
JOURNAL ARTICLE
Bruna Morassi Sasso, Andrelou Fralete Ayres Vallarelli, Patricia Sammarco Rosa, Andrea de Faria Fernandes Belone, Paulo Eduardo Neves Ferreira Velho, Maria Leticia Cintra
Jorge Lobo's disease (JLD) and lepromatous leprosy (LL) share several clinical, histological and immunological features, especially a deficiency in the cellular immune response. Macrophages participate in innate and adaptive inflammatory immune responses, as well as in tissue regeneration and repair. Macrophage function deficiency results in maintenance of diseases. M1 macrophages produce pro-inflammatory mediators and M2 produce anti-inflammatory cytokines. To better understand JLD and LL pathogenesis, we studied the immunophenotype profile of macrophage subtypes in 52 JLD skin lesions, in comparison with 16 LL samples, using a panmacrophage (CD68) antibody and selective immunohistochemical markers for M1 (iNOS) and M2 (CD163, CD204) responses, HAM56 (resident/fixed macrophage) and MAC 387 (recently infiltrating macrophage) antibodies...
March 12, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38484012/analysis-of-diagnostic-test-outcomes-in-a-large-loiasis-cohort-from-an-endemic-region-serological-tests-are-often-false-negative-in-hyper-microfilaremic-infections
#26
JOURNAL ARTICLE
Luzia Veletzky, Kirsten Alexandra Eberhardt, Jennifer Hergeth, Daniel Robert Stelzl, Rella Zoleko Manego, Ruth Kreuzmair, Gerrit Burger, Johannes Mischlinger, Matthew B B McCall, Ghyslain Mombo-Ngoma, Ayôla Akim Adegnika, Selidji Todagbe Agnandji, Pierre Blaise Matsiegui, Bertrand Lell, Peter Kremsner, Benjamin Mordmüller, Dennis Tappe, Michael Ramharter
BACKGROUND: The parasitic disease loiasis is associated with significant morbidity and mortality. Individuals with hyper-microfilaremia (greater than 20,000 microfilariae per mL of blood) may suffer from serious treatment-related or spontaneous adverse events. Diagnosing loiasis remains complex and primarily relies on direct parasite detection. In this study, we analyzed the performance of various diagnostic tests and the influence of parasitological and clinical factors on test outcomes in samples from individuals living in an endemic region...
March 14, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38483823/morphological-transformations-of-sars-cov-2-nucleocapsid-protein-biocondensates-mediated-by-antimicrobial-peptides
#27
JOURNAL ARTICLE
Marco Campanile, Emine D Kurtul, Robert Dec, Simone Möbitz, Pompea Del Vecchio, Luigi Petraccone, Jörg Tatzelt, Rosario Oliva, Roland Winter
Recently, the discovery of antimicrobial peptides (AMPs) as excellent candidates for overcoming antibiotic resistance has attracted significant attention. AMPs are short peptides active against bacteria, cancer cells, and viruses. It has been shown that the SARS-CoV-2 nucleocapsid protein (N-P) undergoes liquid-liquid phase separation in the presence of RNA, resulting in biocondensate formation. These biocondensates are crucial for viral replication as they concentrate the viral RNA with the host cell`s protein machinery required for viral protein expression...
March 14, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38483248/effect-of-weekly-vitamin-d-supplementation-on-the-severity-of-atopic-dermatitis-and-type-2-immunity-biomarkers-in-children-a-randomized-controlled-trial
#28
JOURNAL ARTICLE
Arturo Borzutzky, Carolina Iturriaga, Guillermo Pérez-Mateluna, Francisca Cristi, Lorena Cifuentes, Sergio Silva-Valenzuela, Cristián Vera-Kellet, Carolina Cabalín, Rodrigo Hoyos-Bachiloglu, Cristian Navarrete-Dechent, María Laura Cossio, Catalina Le Roy, Carlos A Camargo
BACKGROUND: Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients. OBJECTIVES: To investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers. METHODS: We performed a randomized, double-blind, placebo-controlled trial...
March 14, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38479496/artificial-intelligence-based-quantitative-coronary-angiography-of-major-vessels-using-deep-learning
#29
JOURNAL ARTICLE
Young In Kim, Jae-Hyung Roh, Jihoon Kweon, Hwi Kwon, Jihye Chae, Keunwoo Park, Jae-Hwan Lee, Jin-Ok Jeong, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Soo-Jin Kang, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Young-Hak Kim
BACKGROUND: Quantitative coronary angiography (QCA) offers objective and reproducible measures of coronary lesions. However, significant inter- and intra-observer variability and time-consuming processes hinder the practical application of on-site QCA in the current clinical setting. This study proposes a novel method for artificial intelligence-based QCA (AI-QCA) analysis of the major vessels and evaluates its performance. METHODS: AI-QCA was developed using three deep-learning models trained on 7658 angiographic images from 3129 patients for the precise delineation of lumen boundaries...
March 11, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38473018/-enterobacterales-biofilm-specific-genes-and-antimicrobial-and-anti-inflammatory-biomarkers-in-the-blood-of-patients-with-ischemic-heart-disease
#30
JOURNAL ARTICLE
Agne Giedraitiene, Vacis Tatarunas, Kornelija Kaminskaite, Ugne Meskauskaite, Svitlana Boieva, Yu Ajima, Ieva Ciapiene, Audrone Veikutiene, Vaidotas Zvikas, Nora Kupstyte-Kristapone, Valdas Jakstas, Dalia Luksiene, Abdonas Tamosiunas, Vaiva Lesauskaite
BACKGROUND: Ischemic heart disease (IHD) is the most prevalent type of cardiovascular disease. The main cause of IHD is atherosclerosis, which is a multifactorial inflammatory disease of blood vessels. Studies show that bacteria might have a significant impact on the pathogenesis of atherosclerosis and plaque rupture. This study aimed to evaluate the complexity of interactions between bacteria and the human body concerning metabolites and bacterial genes in patients with ischemic heart disease...
March 5, 2024: Diagnostics
https://read.qxmd.com/read/38472693/association-patterns-between-lumbar-paraspinal-muscles-and-sagittal-malalignment-in-preoperative-patients-undergoing-lumbar-three-column-osteotomy
#31
JOURNAL ARTICLE
Thomas Caffard, Samuel J Medina, Artine Arzani, Erika Chiapparelli, Lukas Schönnagel, Soji Tani, Gaston Camino-Willhuber, Jiaqi Zhu, David Dalton, Timo Zippelius, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
PURPOSE: We aim to investigate the associations between lumbar paraspinal muscles and sagittal malalignment in patients undergoing lumbar three-column osteotomy. METHODS: Patients undergoing three-column osteotomy between 2016 and 2021 with preoperative lumbar magnetic resonance imaging (MRI) and whole spine radiographs in the standing position were included. Muscle measurements were obtained using a validated custom software for segmentation and muscle evaluation to calculate the functional cross-sectional area (fCSA) and percent fat infiltration (FI) of the m...
March 12, 2024: Spine Deformity
https://read.qxmd.com/read/38471488/human-host-defence-peptide-ll-37-suppresses-tnf%C3%AE-mediated-matrix-metalloproteinases-mmp9-and-mmp13-in-human-bronchial-epithelial-cells
#32
JOURNAL ARTICLE
Anthony Altieri, Courtney Lynn Marshall, Padmanie Ramotar, Dylan Lloyd, Mahadevappa Hemshekhar, Victor Spicer, Anne M van der Does, Neeloffer Mookherjee
INTRODUCTION: TNFα-inducible matrix metalloproteinases (MMP) play a critical role in the process of airway remodelling in respiratory inflammatory disease including asthma. The cationic host defence peptide (CHDP) LL-37 is elevated in the lungs during airway inflammation. However, the impact of LL-37 on TNFα-driven processes is not well understood. Here, we examined the effect of LL-37 on TNFα-mediated responses in human bronchial epithelial cells (HBEC). METHODS: We used a Slow Off-rate Modified Aptamer-based proteomics approach to define the HBEC proteome altered in response to TNFα...
March 12, 2024: Journal of Innate Immunity
https://read.qxmd.com/read/38471068/simultaneous-ammonia-and-organics-degradation-from-municipal-landfill-leachate-by-electrochemical-oxidation
#33
JOURNAL ARTICLE
Pubali Mandal, Ashok K Gupta, Brajesh K Dubey
The two primary issues for wide implementation of the electrochemical oxidation of wastewater are the significant cost of electrode and high energy consumption. On the other side, conventional biological processes and membrane technology have several drawbacks for recalcitrant landfill leachate (LL) treatment. To address these issues, graphite/PbO2 anode was used to treat medium to mature age (biodegradability index, 5-day biochemical oxygen demand/chemical oxygen demand: 0.25) LL. To reduce the cost of the oxidation process and maximize the efficiency, operating conditions were optimized...
March 12, 2024: Environmental Technology
https://read.qxmd.com/read/38470919/a-diterpene-synthase-from-the-sandfly-lutzomyia-longipalpis-produces-the-pheromone-sobralene
#34
JOURNAL ARTICLE
Charles Ducker, Cameron Baines, Jennifer Guy, Antônio Euzébio Goulart Santana, John A Pickett, Neil J Oldham
The phlebotomine sandfly, Lutzomyia longipalpis , a major vector of the Leishmania parasite, uses terpene pheromones to attract conspecifics for mating. Examination of the L. longipalpis genome revealed a putative terpene synthase (TPS), which-upon heterologous expression in, and purification from, Escherichia coli -yielded a functional enzyme. The TPS, termed Ll TPS, converted geranyl diphosphate (GPP) into a mixture of monoterpenes with low efficiency, of which β-ocimene was the major product. ( E,E )-farnesyl diphosphate (FPP) principally produced small amounts of ( E )-β-farnesene, while ( Z,E )- and ( Z,Z )-FPP yielded a mixture of bisabolene isomers...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38467627/three-dimensional-flat-landau-levels-in-an-inhomogeneous-acoustic-crystal
#35
JOURNAL ARTICLE
Zheyu Cheng, Yi-Jun Guan, Haoran Xue, Yong Ge, Ding Jia, Yang Long, Shou-Qi Yuan, Hong-Xiang Sun, Yidong Chong, Baile Zhang
When electrons moving in two dimensions (2D) are subjected to a strong uniform magnetic field, they form flat bands called Landau levels (LLs). LLs can also arise from pseudomagnetic fields (PMFs) induced by lattice distortions. In three-dimensional (3D) systems, there has been no experimental demonstration of LLs  as a type of flat band thus far. Here, we report the experimental realization of a flat 3D LL in an acoustic crystal. Starting from a lattice whose bandstructure exhibits a nodal ring, we design an inhomogeneous distortion corresponding to a specific pseudomagnetic vector potential (PVP)...
March 11, 2024: Nature Communications
https://read.qxmd.com/read/38464674/atomic-structures-of-naphthalene-dipeptide-micelles-unravel-mechanisms-of-assembly-and-gelation
#36
JOURNAL ARTICLE
Ravi R Sonani, Simona Bianco, Bart Dietrich, James Doutch, Emily R Draper, Dave J Adams, Edward H Egelman
Peptide-based biopolymers have gained increasing attention due to their versatile applications. A naphthalene dipeptide (2NapFF) can form chirality-dependent tubular micelles, leading to supramolecular gels. The precise molecular arrangement within these micelles and the mechanism governing gelation have remained enigmatic. We determined, at near-atomic resolution, cryoelectron microscopy structures of the 2NapFF micelles LL-tube and LD-tube, generated by the stereoisomers (l,l)-2NapFF and (l,d)-2NapFF, respectively...
February 21, 2024: Cell reports. Physical science
https://read.qxmd.com/read/38460762/construction-of-exosome-loaded-ll-37-and-its-protection-against-zika-virus-infection
#37
JOURNAL ARTICLE
Chen Wang, Min Li, Xiaohui Xia, Yuxuan Fu, Yi Wang, Wei Xu, Hongqi Wei, Lin Wei
Zika virus (ZIKV) is an enveloped, single-stranded, positive-stranded RNA virus of the genus Flavivirus in the family Flaviviridae. ZIKV can cross the placental barrier and infect the fetus, causing microcephaly, congenital ZIKV syndrome, and even fetal death. ZIKV infection can also lead to testicular damage and male sterility. But no effective drugs and vaccines are available up to now. Previous studies have shown that the cathelicidin antimicrobial peptide LL-37 can protect against ZIKV infection. However, LL-37 is a secreted protein, which can be easily degraded in vivo...
March 7, 2024: Antiviral Research
https://read.qxmd.com/read/38460739/how-do-spino-pelvic-characteristics-change-post-total-hip-arthroplasty-a-longitudinal-assessment-raising-awareness-of-the-postoperative-period
#38
JOURNAL ARTICLE
Aidin Eslam Pour, Moritz Innmann, Franz Reichel, Bibiane Schaper, Tobias Renkawitz, Christian Merle, George Grammatopoulos
INTRODUCTION: Spino-pelvic characteristics, including sacral slope (SS), are commonly evaluated in different positions pre-THA (total hip arthroplasty). This study aimed to: 1) investigate the change in spino-pelvic parameters at 7 days (early) and 1 year post-THA; and 2) identify patient characteristics associated with a change in SS of more than 7° post-THA. METHODS: We prospectively studied 250 patients who underwent unilateral THA [132 women, age 66 years (range, 32 to 88)] and underwent biplanar images preoperatively and at 7 days and 1 year post-THA...
March 7, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38460431/bright-daylight-produces-negative-effects-on-affective-and-cognitive-outcomes-in-nocturnal-rats
#39
JOURNAL ARTICLE
James T Sangma, Zothanmawii Renthlei, Amit K Trivedi
The daily light/dark cycle affects animals' learning, memory, and cognition. Exposure to insufficient daylight illumination negatively impacts emotion and cognition, leading to seasonal affective disorder characterized by depression, anxiety, low motivation, and cognitive impairment in diurnal animals. However, how this affects memory, learning, and cognition in nocturnal rodents is largely unknown. Here, we studied the effect of daytime light illuminance on memory, learning, cognition, and expression of mRNA levels in the hippocampus, thalamus, and cortex, the higher-order learning centers...
March 6, 2024: Journal of Photochemistry and Photobiology. B, Biology
https://read.qxmd.com/read/38457811/stronger-association-of-objective-physical-metrics-with-baseline-patient-reported-outcome-measures-than-preoperative-standing-sagittal-parameters-for-adult-spinal-deformity-patients
#40
JOURNAL ARTICLE
Tej D Azad, Frank J Schwab, Virginie Lafage, Alex Soroceanu, Robert K Eastlack, Renaud Lafage, Khaled M Kebaish, Robert A Hart, Bassel Diebo, Michael P Kelly, Justin S Smith, Alan H Daniels, D Kojo Hamilton, Munish Gupta, Eric O Klineberg, Themistocles S Protopsaltis, Peter G Passias, Shay Bess, Jeffrey L Gum, Richard Hostin, Stephen J Lewis, Christopher I Shaffrey, Douglas Burton, Lawrence G Lenke, Christopher P Ames, Justin K Scheer
OBJECTIVE: Sagittal alignment measured on standing radiography remains a fundamental component of surgical planning for adult spinal deformity (ASD). However, the relationship between classic sagittal alignment parameters and objective metrics, such as walking time (WT) and grip strength (GS), remains unknown. The objective of this work was to determine if ASD patients with worse baseline sagittal malalignment have worse objective physical metrics and if those metrics have a stronger relationship to patient-reported outcome metrics (PROMs) than standing alignment...
March 8, 2024: Journal of Neurosurgery. Spine
keyword
keyword
53633
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.