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https://www.readbyqxmd.com/read/29223015/thiamine-accumulation-and-thiamine-triphosphate-decline-occur-in-parallel-with-atp-exhaustion-during-postmortem-aging-of-pork-muscles
#1
S Muroya, M Oe, K Ojima
We aimed to clarify the mechanisms affecting postmortem thiamine and its phosphoester contents in major edible pork muscles, namely the longissimus lumborum (LL) in addition to vastus intermedius (VI). Metabolomic analysis by capillary electrophoresis-time of flight mass spectrometry revealed that the level of thiamine triphosphate (ThTP), approximately 1.8-fold higher in LL than in VI muscle at 0h postmortem, declined in the first 24h, resulting in an undetectable level at 168h postmortem in both muscles. In contrast, the thiamine content in both muscles increased after 24h postmortem during the aging process...
December 2, 2017: Meat Science
https://www.readbyqxmd.com/read/29222824/elevated-levels-of-the-antimicrobial-peptide-ll-37-in-hidradenitis-suppurativa-are-associated-with-a-th1-th17-immune-response
#2
R Thomi, C Schlapbach, N Yawalkar, D Simon, D Yerly, R E Hunger
Hidradenitis suppurativa (HS) is an inflammatory skin disease with poorly understood immunopathogenic mechanisms. LL-37 is an antimicrobial peptide, which is transcribed from the CAMP (cathelicidin antimicrobial peptide) gene. Previous reports showed upregulated levels of CAMP and LL-37 in HS lesions and therefore the aim of this study was to compare levels of LL-37 in HS to other inflammatory skin diseases and to establish immunomodulatory functions of LL-37 in HS. We confirm an upregulation of the LL-37 peptide in lesional HS skin with comparable levels as in psoriasis patients and are able to positively correlate the presence of LL-37 in HS with the presence of T cells, macrophages, neutrophils, IFNγ, IL-17, IL-23, TNFα, IL-32 and IL-1β...
December 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29222690/risk-factor-of-contralateral-radiculopathy-following-microendoscopy-assisted-minimally-invasive-transforaminal-lumbar-interbody-fusion
#3
Yang Yang, Zhong-Yu Liu, Liang-Ming Zhang, Jian-Wen Dong, Pei-Gen Xie, Rui-Qiang Chen, Bu Yang, Chang Liu, Bin Liu, Li-Min Rong
PURPOSE: Microendoscopy-assisted minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is an advantageous method for treating lumbar degenerative disease; however, some patients show contralateral radiculopathy postoperatively. This study aims to investigate its risk factor. METHODS: A total of 130 cases who underwent microendoscopy-assisted MIS-TLIF at L4-5 level were divided into symptomatic and asymptomatic groups according to the presence of postoperative contralateral radiculopathy...
December 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29219586/intersubband-landau-level-couplings-induced-by-in-plane-magnetic-fields-in-trilayer-graphene
#4
Yuta Asakawa, Satoru Masubuchi, Naoko Inoue, Sei Morikawa, Kenji Watanabe, Takashi Taniguchi, Tomoki Machida
We observed broken-symmetry quantum Hall effects and level crossings between spin- and valley- resolved Landau levels (LLs) in Bernal stacked trilayer graphene. When the magnetic field was tilted with respect to the sample normal from 0° to 66°, the LL crossings formed at intersections of zeroth and second LLs from monolayer-graphene-like and bilayer-graphene-like subbands, respectively, exhibited a sequence of transitions. The results indicate the LLs from different subbands are coupled by in-plane magnetic fields (B_{∥}), which was explained by developing the tight-binding model Hamiltonian of trilayer graphene under B_{∥}...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219416/glassy-anomalies-in-the-low-temperature-thermal-properties-of-a-minimally-disordered-crystalline-solid
#5
J F Gebbia, M A Ramos, D Szewczyk, A Jezowski, A I Krivchikov, Y V Horbatenko, T Guidi, F J Bermejo, J Ll Tamarit
The low-temperature thermal and transport properties of an unusual kind of crystal exhibiting minimal molecular positional and tilting disorder have been measured. The material, namely, low-dimensional, highly anisotropic pentachloronitrobenzene has a layered structure of rhombohedral parallel planes in which the molecules execute large-amplitude in-plane as well as concurrent out-of-plane librational motions. Our study reveals that low-temperature glassy anomalies can be found in a system with minimal disorder due to the freezing of (mostly in-plane) reorientational jumps of molecules between equivalent crystallographic positions with partial site occupation...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29217001/long-term-safety-and-efficacy-of-platinum%C3%A2-chromium-everolimus-eluting-stents-in-coronary-artery-disease-5-year-results-from-the-platinum-trial
#6
Christopher R Kelly, Paul S Teirstein, Ian T Meredith, Bruno Farah, Christophe L Dubois, Robert L Feldman, Joseph Dens, Nobuhisa Hagiwara, Abram Rabinowitz, Didier Carrié, Vincent Pompili, Alain Bouchard, Shigeru Saito, Dominic J Allocco, Keith D Dawkins, Gregg W Stone
OBJECTIVES: The authors sought to evaluate the final 5-year safety and effectiveness of the platinum-chromium everolimus-eluting stent (PtCr-EES) in the randomized trial, as well as in 2 single-arm substudies that evaluated PtCr-EES in small vessels (diameter <2.5 mm; n = 94) and long lesions (24 to 34 mm; n = 102). BACKGROUND: In the multicenter, randomized PLATINUM (PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions), the PtCr-EES was noninferior to the cobalt-chromium everolimus-eluting stent (CoCr-EES) at 1 year in 1,530 patients undergoing percutaneous coronary intervention...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29216797/mandibular-condylar-dimensions-correlation-between-3d-tomography-and-dried-skull-measurements
#7
Rafaela Scariot, Briana Gonsar, Navenett Gill, Fabio Furquim, Paola Fernanda Cotait de Lucas Corso, Paula Cristina Trevillato, Anitha Potluri, Alexandre Rezende Vieira
Objective Compare the anatomical dimensions of mandibular condyles with the same CBCT measurements. Methods Four landmarks were identified on the condyles of dried skulls and are measured with their corresponding areas in CBCT images: Right Width of Condyle (RW), Left Width of Condyle (LW), Right Length of Condyle (RL), and Left Length of Condyle (LL). Results With respect to direct measurements on the dry skulls, statistically significant differences were found between sexes (p < 0.001). When the real values were compared with the CBCT, it was observed that the bias depends on the magnitude of the measurement...
December 8, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/29215493/minimally-invasive-lateral-lumbar-interbody-fusion-for-adult-spinal-deformity-clinical-and-radiological-efficacy-with-minimum-two-years-follow-up
#8
Hyung-Youl Park, Kee-Yong Ha, Young-Hoon Kim, Dong-Gune Chang, Sang-Il Kim, Jae-Won Lee, Joo-Hyun Ahn, Jong-Bin Kim
STUDY DESIGN: A retrospective cohort study OBJECTIVE.: To evaluate the clinical and radiological efficacies of supplementing minimally invasive lateral lumbar interbody fusion (LLIF) with open posterior spinal fusion (PSF) in adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA: Minimally invasive techniques have been increasingly applied for surgery of ASD. Few reports have been published that directly compare LLIF combined with PSF to conventional PSF for ASD...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29211886/bicarbonate-induces-high-level-resistance-to-the-human-antimicrobial-peptide-ll-37-in-staphylococcus-aureus-small-colony-variants
#9
Ping Zhang, John A Wright, Anna Tymon, Sean P Nair
Objectives: Staphylococcus aureus small colony variants (SCVs) cause persistent infections and are resistant to cationic antibiotics. Antimicrobial peptides (AMPs) have been suggested as promising alternatives for treating antibiotic-resistant bacteria. We investigated the capacity of the human cationic AMP LL-37 to kill SCVs in the presence of physiological concentrations of bicarbonate, which are reported to alter bacterial membrane permeability and change resistance of bacteria to AMPs...
December 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29211510/forced-desynchronization-model-for-a-diurnal-primate
#10
Crhistiane A Silva, Laís I M Melo, Alina R Pires, Jordana C Barbalho, Andreia V Melo, Diego A C Fernandes, Everly B Oliveira, Carolina V M Azevedo, Trinitat Cambras, Antoni Díez-Noguera, John Fontenele-Araujo
The circadian system is organized in a hierarchy of multiple oscillators, with the suprachiasmatic nucleus (SCN) as the master oscillator in mammals. The SCN is formed by a group of coupled cell oscillators. Knowledge of this coupling mechanism is essential to understanding entrainment and the expression of circadian rhythms. Some authors suggest that light-dark (LD) cycles with periods near the limit of entrainment may be good models for promoting internal desynchronization, providing knowledge about the coupling mechanism...
December 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29209870/photosynthetic-acclimation-of-grammatophyllum-speciosum-to-growth-irradiance-under-natural-conditions-in-singapore
#11
Jie He, Regina M P Lim, Sabrina H J Dass, Tim W Yam
Grammatophyllum speciosum, a native species to Singapore, have become extinct mainly due to habitat loss. Recently, Singapore has reintroduced G. speciosum into the natural environment under the orchid conservation programme. In this study, leaves of G. speciosum grown under low light (LL) under natural conditions had faster expansion rate and higher specific leaf area than leaves grown under intermediate light (IL) and high light (HL). All leaves had more than 95% midday relative water content. Although midday Fv/Fm ratios were lower in HL leaves than in IL and LL leaves, none of them exhibited chronic photoinhibition...
December 5, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29209258/syntactic-and-story-structure-complexity-in-the-narratives-of-high-and-low-language-ability-children-with-autism-spectrum-disorder
#12
Eleni Peristeri, Maria Andreou, Ianthi M Tsimpli
Although language impairment is commonly associated with the autism spectrum disorder (ASD), the Diagnostic Statistical Manual no longer includes language impairment as a necessary component of an ASD diagnosis (American Psychiatric Association, 2013). However, children with ASD and no comorbid intellectual disability struggle with some aspects of language whose precise nature is still outstanding. Narratives have been extensively used as a tool to examine lexical and syntactic abilities, as well as pragmatic skills in children with ASD...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29208979/induction-of-antimicrobial-peptides-secretion-by-il-1%C3%AE-enhances-human%C3%A2-amniotic-membrane-for-regenerative-medicine
#13
Fatemeh A Tehrani, Khashayar Modaresifar, Sara Azizian, Hassan Niknejad
Due to antibacterial characteristic, amnion has been frequently used in different clinical situations. Developing an in vitro method to augment endogenous antibacterial ingredient of amniotic epithelial and mesenchymal stem cells is desirable for a higher efficacy of this promising biomaterial. In this study, epithelial or mesenchymal side dependent effect of amniotic membrane (AM) on antibacterial activity against some laboratory and clinical isolated strains was investigated by modified disk diffusion method and colony count assay...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208061/antichagasic-effect-of-crotalicidin-a-cathelicidin-like-vipericidin-found-in-crotalus-durissus-terrificus-rattlesnake-s-venom-gland
#14
Izabel Cristina Justino Bandeira, Danya Bandeira-Lima, Clarissa Perdigão Mello, Ticiana Praciano Pereira, Ramon Róseo Paula Pessoa Bezerra De Menezes, Tiago Lima Sampaio, Cláudio Borges Falcão, Gandhi Rádis-Baptista, Alice Maria Costa Martins
Cathelicidins are antimicrobial peptides produced by humans and animals in response to various pathogenic microbes. Crotalicidin (Ctn), a cathelicidin-related vipericidin from the South American Crotalus durissus terrificus rattlesnake's venom gland, and its fragments have demonstrated antimicrobial and antifungal activity, similarly to human cathelicidin LL-37. In order to provide templates for the development of modern trypanocidal agents, the present study evaluated the antichagasic effect of these four peptides (Ctn, Ctn[1-14], Ctn[15-34] and LL-37)...
December 6, 2017: Parasitology
https://www.readbyqxmd.com/read/29207673/comparison-among-conventional-and-advanced-mri-18f-fdg-pet-ct-phenotype-and-genotype-in-glioblastoma
#15
Maria Consuelo Valentini, Marta Mellai, Laura Annovazzi, Antonio Melcarne, Tetyana Denysenko, Paola Cassoni, Cristina Casalone, Cristiana Maurella, Silvia Grifoni, Piercarlo Fania, Angelina Cistaro, Davide Schiffer
Glioblastoma (GB) is a highly heterogeneous tumor. In order to identify in vivo the most malignant tumor areas, the extent of tumor infiltration and the sites giving origin to GB stem cells (GSCs), we combined positron emission tomography/computed tomography (PET/CT) and conventional and advanced magnetic resonance imaging (MRI) with histology, immunohistochemistry and molecular genetics. Prior to dura opening and tumor resection, forty-eight biopsy specimens [23 of contrast-enhancing (CE) and 25 of non-contrast enhancing (NE) regions] from 12 GB patients were obtained by a frameless image-guided stereotactic biopsy technique...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206168/significance-and-diagnostic-role-of-antimicrobial-cathelicidins-ll-37-peptides-in-oral-health
#16
REVIEW
Zohaib Khurshid, Mustafa Naseem, Faris Yahya I Asiri, Maria Mali, Rabia Sannam Khan, Haafsa Arshad Sahibzada, Muhammad Sohail Zafar, Syed Faraz Moin, Erum Khan
Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity...
December 5, 2017: Biomolecules
https://www.readbyqxmd.com/read/29203821/localized-solutions-of-lugiato-lefever-equations-with-focused-pump
#17
Wesley B Cardoso, Luca Salasnich, Boris A Malomed
Lugiato-Lefever (LL) equations in one and two dimensions (1D and 2D) accurately describe the dynamics of optical fields in pumped lossy cavities with the intrinsic Kerr nonlinearity. The external pump is usually assumed to be uniform, but it can be made tightly focused too-in particular, for building small pixels. We obtain solutions of the LL equations, with both the focusing and defocusing intrinsic nonlinearity, for 1D and 2D confined modes supported by the localized pump. In the 1D setting, we first develop a simple perturbation theory, based in the sech ansatz, in the case of weak pump and loss...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29201845/k%C3%A3-mmell-s-disease-treated-with-percutaneous-vertebroplasty-minimum-1-year-follow-up
#18
Jae Won Park, Jong-Hwa Park, Hong Jun Jeon, Jong Young Lee, Byung Moon Cho, Se-Hyuck Park
Objective: To evaluate the radiographic and clinical outcomes of percutaneous vertebroplasty (PVP) in patients with Kümmell's disease. Methods: A retrospective review was conducted for 19 vertebrae in 18 patients, between January 2012 and June 2016. A visual analogue scale (VAS) score was used to determine each patient's subjective level of pain (0=no pain to 10=severe pain) preoperative, immediately postoperative and at the last follow-up (at least 12 months after PVP)...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29200482/computer-simulation-of-two-level-pedicle-subtraction-osteotomy-for-severe-thoracolumbar-kyphosis-in-ankylosing-spondylitis
#19
Ning Zhang, Hao Li, Zheng-Kuan Xu, Wei-Shan Chen, Qi-Xin Chen, Fang-Cai Li
Background: Advanced ankylosing spondylitis is often associated with thoracolumbar kyphosis, resulting in an abnormal spinopelvic balance and pelvic morphology. Different osteotomy techniques have been used to correct AS deformities, unfortunnaly, not all AS patients can gain spinal sagittal balance and good horizontal vision after osteotomy. Materials and Methods: Fourteen consecutive AS patients with severe thoracolumbar kyphosis who were treated with two-level PSO were studied retrospectively...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29198597/the-position-of-the-aorta-relative-to-the-spine-in-patients-with-pott-s-thoracolumbar-angular-kyphosis
#20
Yan Liang, Yongfei Zhao, Haiying Liu, Zheng Wang
STUDY DESIGN: Analyze the position of the aorta in patients with Pott's thoracolumbar angular kyphosis by computed tomography. OBJECTIVE: To investigate the anatomic position of the aorta relative to spine in patients with Pott's thoracolumbar angular kyphosis. SUMMARY OF BACKGROUND DATA: The complication of aorta injury is rare in the procedure of spinal osteotomy for the correction of Pott's thoracolumbar angular kyphotic deformity. However, there would be a disastrous consequence once it happened...
November 30, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
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