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https://www.readbyqxmd.com/read/29036973/-predictive-value-of-cardiac-magnetic-resonance-derived-parameters-on-the-improvement-of-left-ventricular-function-in-patients-with-acute-viral-myocarditis
#1
H C Ouyang, F C Ouyang, L L Mai, Y Y Chen, Y Z Hu, H X Chen, W S Li
Objective: To evaluate the predictive value of cardiac magnetic resonance (CMR)-derived parameters on the improvement of left ventricular function in patients with acute viral myocarditis. Methods: Forty patients, who referred for acute viral myocarditis in our hospital from September 2011 to September 2015, were prospectively enrolled in this study.All patients were examined by CMR during hospitalization for acute viral myocarditis (baseline) and after 12 months.The CMR sequences include: two dimension steady state free precession, 2D SSFP; triple inversion recovery, triple IR; early gadolinium enhancement; phase sensitive inversion recovery turbo field echo, PSIR TFE...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29034858/streptomyces-kalpinensis-sp-nov-an-actinomycete-isolated-from-a-salt-water-beach
#2
Guo-Quan Ma, Zhan-Feng Xia, Chuan-Xing Wan, Yao Zhang, Xiao-Xia Luo, Li-Li Zhang
A novel actinobacterium designated TRM 46509(T) was isolated from a salt water beach at Kalpin, Xinjiang, north-west China. The strain was aerobic and Gram-stain-positive, with an optimum NaCl concentration for growth of 1 % (w/v). The isolate formed sparse aerial mycelium and produced spiral spores at the end of the aerial mycelium on Gauze's No. 1 medium. The isolate contained ll-diaminopimelic acid as the diagnostic diamino acid and ribose as the major whole-cell sugar. The polar lipids included diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol, phosphatidylinositol mannosides and an unidentified phospholipid...
October 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29034266/bladder-pain-in-an-ll-37-interstitial-cystitis-and-painful-bladder-syndrome-model
#3
Wanjian Jia, Austin J Schults, Mark Martin Jensen, Xiangyang Ye, Jeremiah A Alt, Glenn D Prestwich, Siam Oottamasathien
Our goal was to evaluate the pain response in an LL-37 induced murine model for interstitial cystitis/painful bladder syndrome (IC/PBS). In particular, we sought to characterize the dose dependence, time-course, and relationship of LL-37 induced bladder inflammation and pain. The IC/PBS model was induced in C57Bl/6 mice by instilling 50 μL of LL-37, an immunomodulatory human cathelicidin (anti-microbial peptide), in the bladder for 1 hr. Pain responses were measured using von Frey filaments (0.04 gm to 4.0 gm) before and after LL-37 instillation...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29034104/fibroblasts-the-unknown-sentinels-eliciting-immune-responses-against-microorganisms
#4
REVIEW
Luis Antonio Bautista-Hernández, José Luis Gómez-Olivares, Beatriz Buentello-Volante, Victor Manuel Bautista-de Lucio
Fibroblasts are present in all tissues but predominantly in connective tissues. Some of their functions include contractility, locomotion, collagen and elastin fiber production, and the regulation and degradation of the extracellular matrix. Also, fibroblasts act as sentinels to produce inflammatory mediators in response to several microorganisms. There is evidence that fibroblasts can synthesize toll-like receptors (TLRs), antimicrobial peptides, proinflammatory cytokines, chemokines, and growth factors, which are important molecules involved in innate immune response against microorganisms...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29033635/evaluation-of-5-httlpr-gene-polymorphism-and-resilience-components-on-the-development-of-psychopathology-in-adolescent-sexual-abuse-cases
#5
Gresa Çarkaxhiu Bulut, Ayşe Rodopman Arman, İlter Güney, Pınar Gültepe
INTRODUCTION: More than one-fourth adolescents are exposed to unexpected frightening experiences and traumas until adulthood. In this study, we aimed to determine the potential role of serotonin transporter (5-HTT) gene polymorphism regarding resilience factors in the symptom variability of individuals exposed to sexual abuse. METHODS: Adolescents aged 11-17 years, who were admitted to the Marmara University Child Psychiatry Outpatient Clinic Forensic division with sexual abuse experience history, were informed about the research, and volunteers were included in the study...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29033090/the-antimicrobial-peptide-ll-37-as-a-possible-adjunct-for-the-proliferation-and-differentiation-of-dental-pulp-stem-cells
#6
Noala Vicensoto Moreira Milhan, Patricia Pimentel de Barros, Elis Andrade de Lima Zutin, Felipe Eduardo de Oliveira, Carlos Henrique Ribeiro Camargo, Samira Esteves Afonso Camargo
INTRODUCTION: This study evaluated the biocompatibility of 5 and 10 μg/mL LL-37 in vitro and its effect on the differentiation of human dental pulp stem cells (DPSCs) into odontoblast-like cells. METHODS: Cell viability, genotoxicity, nitric oxide production, cell cycle, dentine sialophosphoprotein (DSPP) production, and DSPP gene expression. RESULTS: Concentrations of 5 and 10 μg/mL of LL-37 were not cytotoxic and generally increased cell viability, especially on the third day (P < ...
October 12, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29028850/effect-of-different-degrees-of-mesial-implant-inclination-on-the-retention-and-stability-of-two-implant-mandibular-overdentures-retained-with-stud-attachments-an-in-vitro-study
#7
Moustafa Abdou ELsyad, Omar Emhemed Abo Hatem, Ahmad Fathalla Shawky, Radwa Mohsen Kamal Emera
PURPOSE: To evaluate the effect of different degrees of mesial implant inclinations on the retention and stability of two-implant mandibular overdentures retained with stud attachments. MATERIALS AND METHODS: Four experimental mandibular acrylic models were constructed. Two laboratory implants were inserted in the canine areas of each model with the following degrees of mesial inclinations: 0, 5, 10, and 20 degrees. Experimental overdentures were connected to the implants with Locator extra-light retention (Le), Locator light retention (Ll), and Locator medium retention (Lm)...
October 13, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29028793/clinico-pathological-features-of-erythema-nodosum-leprosum-a-case-control-study-at-alert-hospital-ethiopia
#8
Edessa Negera, Stephen L Walker, Selfu Girma, Shimelis N Doni, Degafe Tsegaye, Saba M Lambert, Munir H Idriss, Yohanis Tsegay, Hazel M Dockrell, Abraham Aseffa, Diana N Lockwood
BACKGROUND: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. ENL is treated mainly with corticosteroids and corticosteroids are often required for extended periods of time which may lead to serious adverse effects...
October 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29024481/late-leakage-after-anterior-resection-a-defunctioning-stoma-alters-the-clinical-course-of-anastomotic-leakage
#9
H Jutesten, J Draus, J Frey, G Neovius, G Lindmark, P Buchwald, M L Lydrup
AIM: Anastomotic leakage (AL) is common after anterior resection (AR). Long term clinical outcomes of AL including late presenting leakages (LL) are not well studied. This study was undertaken to assess clinical features of LL with respect to incidence, association to predisposing factors, and need for reintervention. METHODS: The Swedish Colorectal Cancer Registry (SCRCR) was explored for AL cases after AR for rectal cancer in patients operated in the south of Sweden from 01-01(_) 2001 to 31-12-2011...
October 12, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29022545/nocardioides-litorisoli-sp-nov-isolated-from-lakeside-soil
#10
Yu Wang, Ding Xu, Anna Luo, Gejiao Wang, Shixue Zheng
A Gram-stain-positive, rod-shaped, non-spore-forming bacterium, designated as x-2(T), was isolated from lakeside soil of Sayram in the Xinjiang Uygur Autonomous Region, PR China. On the basis of 16S rRNA gene sequences, strain x-2(T) belongs to the genus Nocardioides in the family Nocardioidaceae, being most closely related to Nocardioides panacisoli Gsoil 346(T) (97.36 % 16S rRNA gene sequence similarity). Strain x-2(T) was characterized chemotaxonomically and found to have ll-diaminopimelic acid in the cell-wall peptidoglycan, phosphatidylglycerol, diphosphatidylglycerol, glycolipids and another three unknown phospholipids as the major polar lipids, MK-8(H4) as the predominant menaquinone and C18 : 1ω9c, iso-C16 : 0, C17 : 1ω8c and C16 : 0 as the major fatty acids...
October 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29022391/kr-12-a5-is-a-non-cytotoxic-agent-with-potent-antimicrobial-effects-against-oral-pathogens
#11
Karina Sampaio Caiaffa, Loiane Massunari, Marcelle Danelon, Gabriel Flores Abuna, Telma Blanca Lombardo Bedran, Norival Alves Santos-Filho, Denise Madalena Palomari Spolidorio, Natalia Leal Vizoto, Eduardo Maffud Cilli, Cristiane Duque
This study evaluated the cytotoxicity and antimicrobial activity of analogs of cationic peptides against microorganisms associated with endodontic infections. L-929 fibroblasts were exposed to LL-37, KR-12-a5 and hBD-3-1C(V) and chlorhexidine (CHX, control), and cell metabolism was evaluated with MTT. The minimal inhibitory concentration (MIC) and the minimal bactericidal/fungicidal concentration (MBC/MFC) of the peptides and CHX were determined against oral pathogens associated with endodontic infections. Enterococcus faecalis and Streptococcus mutans biofilms were cultivated in bovine dentin blocks, exposed to different concentrations of the most efficient antimicrobial peptide and analyzed by confocal laser scanning microscopy...
October 12, 2017: Biofouling
https://www.readbyqxmd.com/read/29016433/under-correction-of-sagittal-deformities-based-on-age-adjusted-alignment-thresholds-leads-to-worse-hrqol-while-over-correction-provides-no-additional-benefit
#12
Justin K Scheer, Renaud Lafage, Frank J Schwab, Barthelemy Liabaud, Justin S Smith, Gregory M Mundis, Richard Hostin, Christopher I Shaffrey, Douglas C Burton, Robert A Hart, Han Jo Kim, Shay Bess, Munish Gupta, Virginie Lafage, Christopher P Ames
STUDY DESIGN: Retrospective review of prospectively-collected database. OBJECTIVE: This study aims to compare 2-year clinical outcomes of patients who underwent surgical reconstructions based on their achievement to age-adjusted alignment ideals. SUMMARY OF BACKGROUND DATA: Recent research in sagittal plane has proposed age-adjusted alignment thresholds. However, the impact of these thresholds on post-operative HRQL is yet to be investigated...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28991896/t-cell-regulation-in-erythema-nodosum-leprosum
#13
Edessa Negera, Steven L Walker, Kidist Bobosha, Rawleigh Howe, Abraham Aseffa, Hazel M Dokrell, Diana N Lockwood
Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. However, immune-complexes and cell-mediated immunity have been suggested in the pathogenesis of ENL. The aim of this study was to investigate the regulatory T-cells in patients with ENL...
October 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28988788/a-systematic-review-and-meta-analysis-on-the-treatment-of-liver-hydatid-cyst-comparing-laparoscopic-and-open-surgeries
#14
REVIEW
Massoud Sokouti, Ramin Sadeghi, Saeid Pashazadeh, Saeed Eslami Hasan Abadi, Mohsen Sokouti, Peyman Rezaei-Hachesu, Morteza Ghojazadeh, Babak Sokouti
BACKGROUND AND STUDY AIMS: There is an academic debate regarding surgical interventions for liver hydatid cyst disease. The purpose of the current systematic review and meta-analysis study was to analyse the pros and cons of open surgery and laparoscopic techniques, considering the outcomes of liver hydatid cysts. METHODS: Descriptive Boolean queries were used to search PubMed and Scopus for articles published between January 2000 and December 2016 to evaluate the outcomes of liver hydatid cyst in terms of mortality, post-operative complications, cure rate and recurrences...
October 4, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28988565/effect-of-age-and-gender-on-carcass-traits-and-meat-quality-of-farmed-brown-hares
#15
A Trocino, M Birolo, S Dabbou, F Gratta, N Rigo, G Xiccato
A total of 48 sub-adult hares and adult reproducing farmed hares were used to characterize carcass and meat traits according to the age and gender of animals. With respect to carcass traits, when age increased, the carcass weight significantly increased (2022 to 3391 g; P<0.001), but dressing out percentages did not change. The dissectible fat (1.3% to 2.2%; P<0.05) and Longissimus lumborum (LL) proportions (13.5% to 14.5%; P<0.001) and muscle-to-bone ratio of hind legs (5.11 to 6.23; P<0.001) increased, whereas the hind leg proportions decreased (37...
October 9, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28988412/cognitive-outcomes-among-latino-survivors-of-childhood-acute-lymphoblastic-leukemia-and-lymphoma-a-cross-sectional-cohort-study-using-culturally-competent-performance-based-assessment
#16
Laura Bava, Alexis Johns, Kimberly Kayser, David R Freyer
BACKGROUND: This study sought to characterize cognitive outcomes among Latino survivors of childhood acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL). PROCEDURE: In this cross-sectional cohort study, Latino survivors of ALL (n = 57) and LL (n = 5) aged 6-16 years were pooled and evaluated using validated measures of cognitive, academic, and behavioral function and English language proficiency. Performance was compared with norms using single-sample t-tests...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28987851/effect-of-single-level-transforaminal-lumbar-interbody-fusion-on-segmental-and-overall-lumbar-lordosis-in-patients-with-lumbar-degenerative-disease
#17
Xiaofei Cheng, Feng Zhang, Kai Zhang, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zhao
OBJECTIVE: This study investigated the ability of transforaminal lumbar interbody fusion (TLIF) to improve lumbar lordosis (LL). METHODS: Ninety-two patients receiving single-level TLIF due to lumbar degenerative disease were divided into low back pain, radiculopathy and neurogenic claudication group according to their symptoms. Preoperative and postoperative measures including segmental LL (SLL), whole LL (WLL), pelvic incidence (PI), pelvic tilt (PT), thoracic kyphosis (TK), sagittal vertical axis (SVA), visual analog scale (VAS) for back and leg pain and Oswestry Disability Index (ODI) were used for evaluation of radiographic and clinical outcomes...
October 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987526/anterior-lumbar-sagittal-alignment-after-anterior-or-lateral-interbody-fusion
#18
M Afathi, F Zairi, P Devos, M Allaoui, P Marinho, D Chopin, R Assaker
PURPOSE: Anterior or lateral interbody fusion is a treatment option for lumbar disc disease. A segmental change occurs after such surgery. This study was designed to evaluate the changes in the lumbar regional alignment after a single or two-level standalone anterior or lateral interbody fusion (ALIF or LLIF). METHODS: Data from patients referred to our institution between March 2013 and November 2015 for standalone ALIF or LLIF for low-grade isthmic spondylolisthesis or degenerative discopathy were retrospectively included in our analysis...
October 4, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28987032/functionalized-pva-silk-blended-nanofibrous-mats-promote-diabetic-wound-healing-via-regulation-of-extracellular-matrix-and-tissue-remodeling
#19
Dimple Chouhan, G Janani, Bijayashree Chakraborty, Samit K Nandi, Biman B Mandal
Chronic cutaneous ulcers, a complex pathophysiological diabetic condition, represent a critical clinical challenge in the current diabetes mellitus pandemic. Consequently, there is a compelling need for bioactive dressings which can trigger healing processes for complete wound repair. Silk fibroin (SF), a natural protein polymer from mulberry and non-mulberry silkworms, has properties that support accelerated wound healing rate. SF from non-mulberry variety possesses additional cell-binding motifs (RGD), offering cell-material interactions...
October 7, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28985593/effects-of-chilled-then-frozen-storage-up-to-52weeks-on-an-indicator-of-protein-oxidation-and-indices-of-protein-degradation-in-lamb-m-longissimus-lumborum
#20
Cassius E O Coombs, Benjamin W B Holman, Damian Collins, Matthew J Kerr, Michael A Friend, David L Hopkins
This study investigated the protein oxidation properties of lamb following chilled-then-frozen storage. Experimental (n=360) M. longissimus lumborum (LL) were randomly sampled from the boning room of a commercial Australian abattoir, at 24h post mortem, and assigned to five chilled storage periods (0, 2, 4, 6 and 8weeks) and six subsequent frozen storage periods (0, 4, 8, 12, 24 and 52weeks). Upon completion of each storage treatment combination, corresponding LL were sub-sectioned and analysed for carbonyl content, protein solubility, nitrate/nitrite content, particle size analysis and estimated myoglobin fractions...
September 28, 2017: Meat Science
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