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https://www.readbyqxmd.com/read/29665030/dermatologic-toxicity-from-novel-therapy-using-antimicrobial-peptide-ll-37-in-melanoma-a-detailed-examination-of-the-clinicopathologic-features
#1
Tsetan Dolkar, Celestine M Trinidad, Kelly C Nelson, Rodabe N Amaria, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Jonathan L Curry, Phyu P Aung
LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. We report dermatologic toxicity in a 63-year-old woman with stage IIIC melanoma of the right calf and inguinal lymph nodes...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29664817/postoperative-status-of-global-sagittal-alignment-with-compensation-in-adult-spinal-deformity
#2
Satoshi Inami, Hiroshi Moridaira, Daisaku Takeuchi, Haruki Ueda, Yo Shiba, Futoshi Asano, Hiromichi Aoki, Hiroshi Taneichi
STUDY DESIGN: Retrospective study of consecutive patients undergoing surgery for adult spinal deformity (ASD). OBJECTIVE: The aim of this study was to classify postoperative ASD patients by sagittal compensation and characterize the features of each group. SUMMARY OF BACKGROUND DATA: Sagittal compensatory mechanisms to keep the erect position would function in not only non-operative ASD patients, but also in postoperative patients. However, details of sagittal compensatory mechanisms after surgery have been unclear, because the majority of previous studies examined the compensatory mechanisms in non-operative patients METHODS...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29664814/spinal-sagittal-alignment-in-patients-with-dropped-head-syndrome
#3
Kazuma Murata, Endo Kenji, Hidekazu Suzuki, Taichiro Takamatsu, Hirosuke Nishimura, Yuji Matsuoka, Yasunobu Sawaji, Hidetoshi Tanaka, Kengo Yamamoto
STUDY DESIGN: This is a retrospective radiographic study of a consecutive case series of dropped head syndrome (DHS) at a single tertiary referral center. OBJECTIVE: The aim was to clarify the spinal sagittal alignment of DHS. SUMMARY OF BACKGROUND DATA: DHS is characterized by chin-on-chest deformity and devastatingly impedes activities of daily living in affected individuals. Among various forms of DHS, isolated neck extensor myopathy (INEM) is considered to cause the chin-on-chest symptom in the absence of specific abnormality...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29660377/apathy-following-traumatic-brain-injury-a-review
#4
Andrew Worthington, Rodger Ll Wood
Apathy is a common problem after traumatic brain injury (TBI) and can have a major impact on cognitive function, psychosocial outcome and engagement in rehabilitation. For scientists and clinicians it remains one of the least understood aspects of brain-behaviour relationships encompassing disturbances of cognition, motivation, emotion and action, and is variously an indication of organic brain disease or psychiatric disorder. Apathy can be both sign and symptom and has been proposed as a diagnosis in its own right as well as a secondary feature of other conditions...
April 13, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29660107/recess-environment-and-curriculum-intervention-on-children-s-physical-activity-iplay
#5
Claudio R Nigg, Eve Kutchman, Katie Amato, Christine A Schaefer, Guangxiang Zhang, Md Mahabub Ul Anwar, Peter Anthamatten, Raymond C Browning, Lois Brink, James Hill
Understanding the impacts of the built environment on physical activity (PA) is essential to promoting children's PA. The purpose of this study was to investigate the effects of schoolyard renovations and a PA recess curriculum alone and in combination on children's PA. This was a 2 (learning landscape [LL] vs. non-LL) × 2 (curriculum intervention vs. no curriculum intervention) factorial design with random assignment to the curriculum intervention, and six elementary schools per condition. PA outcomes were assessed preprogram, mid-program, immediate postprogram, and one year postprogram...
April 10, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29659931/shade-compromises-the-photosynthetic-efficiency-of-nadp-me-less-than-pep-ck-and-nad-me-c4-grasses
#6
Balasaheb V Sonawane, Robert E Sharwood, Spencer Whitney, Oula Ghannoum
The high-energy cost and apparently low plasticity of C4 photosynthesis, compared to C3 photosynthesis, may limit the productivity and distribution of C4 plants in low light (LL) environments. C4 photosynthesis evolved numerous times but it remains unclear how different biochemical subtypes perform under LL. We grew eight C4 grasses belonging to three biochemical subtypes (NADP-ME, NAD-ME and PEP-CK) under shade (16% sunlight) or control (full sunlight) conditions and measured their photosynthetic characteristics at both low and high light...
April 5, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29659309/peak-expiratory-flow-in-obese-subjects-in-different-positions
#7
Jéssica Perossi Nascimento, Larissa Perossi, Mayara Holtz, José Antônio Baddini-Martinez, Hugo Celso Dutra De Souza, Ada Clarice Gastaldi
OBJECTIVE: To analyze the peak expiratory flow (PEF) in obese subjects in standing (ST), seated (SE), supine (SU), prone (PR), and right and left lateral decubitus (RL and LL) positions. METHODS: 36 obese volunteers, aged between 18 and 54 years, and nonsmokers, were evaluated by anthropometric data; spirometry; international physical activity questionnaire (IPAQ); and PEF in ST, SE, SU, PR, RL, and LL positions, randomly. RESULTS: The mean age was 27...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29657933/relationship-between-height-of-ethmoid-skull-base-and-length-of-lateral-lamella-by-sectional-coronal-computed-tomography-scan-before-endoscopic-sinus-surgery
#8
Seyyed Mustafa Hashemi, Nezamoddin Berjis, Hamidreza Ebrahimi
Background: Damage to ethmoid skull base (ESB) and lateral lamella (LL) during endoscopic sinus surgery (ESS) causes penetration into the brain. This study is aimed to determine the relationship between the height of ESB and length of LL by sectional coronal computed tomography (CT) scans before ESS. Materials and Methods: In a cross-sectional study, 100 patients admitted to ENT clinic of Al-Zahra Hospital, filled the consents regarding the use of CT scan stereotype...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29652823/molecular-dynamics-simulations-of-human-antimicrobial-peptide-ll-37-in-model-popc-and-popg-lipid-bilayers
#9
Liling Zhao, Zanxia Cao, Yunqiang Bian, Guodong Hu, Jihua Wang, Yaoqi Zhou
Cathelicidins are a large family of cationic antimicrobial peptides (AMPs) found in mammals with broad spectrum antimicrobial activity. LL-37 is the sole amphipathic α-helical AMP from human Cathelicidins family. In addition to its bactericidal capability, LL-37 has antiviral, anti-tumor, and immunoregulatory activity. Despite many experimental studies, its molecular mechanism of action is not yet fully understood. Here, we performed three independent molecular dynamics simulations (600 ns or more) of a LL-37 peptide in the presence of 256 lipid bilayers with 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphoglycerol (POPG) mimicking bacterial and 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine (POPC) mimicking mammalian membranes...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652303/-respiratory-hypercapnic-hypoxic-training-is-an-effective-component-of-complex-therapy-of-polyneuropathy-in-children-with-diabetes-type-1
#10
K V Smirnov, Yu V Smirnova, V P Kulikov, O M Nazarkina
AIM: To study the effectiveness of respiratory hypercapnic-hypoxic training in complex treatment of neuropathy due to diabetes type 1. MATERIAL AND METHODS: Fifty children, 31 girls and 19 boys, were examined. The inclusion criteria were the presence of polyneuropathy, verified on the basis of clinical data and electromyographic changes. The patients were divided into 2 groups: the main group (n=25, 15 girls and 10 boys, mean age 12.9±1.8 years (M±SD) and the comparison group (n=25, 16 girls and 9 boys, mean age 13...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29649824/end-organ-saturation-differences-in-early-neonatal-transition-for-left-versus-right-sided-congenital-heart-disease
#11
Gabriel Altit, Shazia Bhombal, Theresa A Tacy, Valerie Y Chock
BACKGROUND: For neonates with congenital heart disease (CHD), left-sided (LL) and right-sided (RL) single ventricular physiologies (LL, hypoplastic left heart syndrome; RL, tricuspid atresia or pulmonary atresia with intact ventricular septum) may demonstrate distinct changes in tissue saturation in the first 72 h of life. Near-infrared spectroscopy (NIRS) can measure regional cerebral saturation (Csat) and renal saturation (Rsat) to clarify differences between LL and RL over time. OBJECTIVES: Our primary objective was to measure changes in Csat and Rsat in the first 72 h of life using NIRS between CHD infants with LL compared to RL...
April 12, 2018: Neonatology
https://www.readbyqxmd.com/read/29644909/advanced-ercp-techniques-for-the-extraction-of-complex-biliary-stones-a-single-referral-center-s-12-year-experience
#12
Nicholas G Brown, Joel Camilo, Eric Nordstrom, Roy D Yen, Norio Fukami, Brian C Brauer, Sachin Wani, Stuart K Amateau, Augustin R Attwell, Raj J Shah
OBJECTIVES: Advanced ERCP techniques (AETs) for difficult biliary stones include peroral cholangioscopy (POC) with electrohydraulic/laser lithotripsy (EHL/LL), endoscopic papillary large balloon dilation (EPLBD) and mechanical lithotripsy (ML). We assess the efficacy of AETs. METHODS: A retrospective query for AETs. PRIMARY OUTCOME: Complete duct clearance. Secondary outcome: Complete duct clearance by technique. Statistical Analysis version 9...
April 12, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29644526/upregulated-expression-of-human-cathelicidin-ll-37-in-hypercholesterolemia-and-its-relationship-with-serum-lipid-levels
#13
Yun-Xi Li, Bao-Zhen Li, Da-Zun Yan
Dyslipidemia in patients with hypercholesterolemia has been recently linked to increased human cathelicidin LL-37 (LL-37) serum concentration. We tested a hypothesis that upregulated expression of LL-37 gene in peripheral blood leucocytes is involved in dyslipidemia in patients with hypercholesteremia. Patients with hypercholesterolemia were used in the study. Expression of LL-37 and human glyceraldehyde-3-phosphate dehydrogenase in peripheral blood leucocytes were quantified by real-time RT-PCR. Serum LL-37 concentration was estimated by enzyme-linked immunosorbent assay...
April 11, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29642921/feasibility-of-robot-based-perturbed-balance-training-during-treadmill-walking-in-a-high-functioning-chronic-stroke-subject-a-case-control-study
#14
Zlatko Matjačić, Matjaž Zadravec, Andrej Olenšek
BACKGROUND: For stroke survivors, balance deficits that persist after the completion of the rehabilitation process lead to a significant risk of falls. We have recently developed a balance-assessment robot (BAR-TM) that enables assessment of balancing abilities during walking. The purpose of this study was to test feasibility of using the BAR-TM in an experimental perturbed-balance training program with a selected high-functioning stroke survivor. METHODS: A control and an individual with right-side chronic hemiparesis post-stroke were studied...
April 11, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29629356/feasibility-and-oncologic-safety-of-low-ligation-of-inferior-mesenteric-artery-with-d3-dissection-in-ct3n0m0-sigmoid-colon-cancer
#15
Kyung Ha Lee, Jin Soo Kim, Ji Yeon Kim
Purpose: There is no standard consensus for the ligation level of the inferior mesenteric artery during radical resection of sigmoid colon cancer. Especially, there is little research about low ligation combined with D3 dissection. The study was performed to compare feasibility and oncologic safety between low ligation with D3 dissection to high ligation in intermediately advanced sigmoid colon cancer. Methods: From January 2008 to December 2013, 134 patients who underwent radical surgery for cT3N0M0 sigmoid colon cancer were evaluated retrospectively...
April 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29627483/effects-of-fluticasone-propionate-and-budesonide-on-the-expression-of-immune-defense-genes-in-bronchial-epithelial-cells
#16
M van den Berge, M R Jonker, A Miller-Larsson, D S Postma, I H Heijink
BACKGROUND: COPD patients have increased risk of pneumonia when treated with fluticasone propionate (FP), whereas this is generally not the case with budesonide (BUD) treatment. We hypothesized that BUD and FP differentially affect the expression of immune defense genes. METHODS: Human bronchial epithelial 16HBE cells and air-liquid interface (ALI)-cultured primary bronchial epithelial cells (PBECs) were pre-treated with clinically equipotent concentrations of BUD or FP (0...
April 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29624162/streptomyces-boninensis-sp-nov-isolated-from-soil-from-a-limestone-cave-in-the-ogasawara-islands
#17
Akira Také, Yuki Inahashi, Satoshi Ōmura, Yōko Takahashi, Atsuko Matsumoto
Actinomycete strain K11-0400T was isolated from a soil sample collected in the Ogasawara Islands (also known as the Bonin Islands), Tokyo, Japan. Mature spore chains of strain K11-0400T had more than 20 spores per chain. The strain contained ll-diaminopimelic acid as the diamino acid in whole-cell hydrolysates, and MK-9(H6) and MK-9(H4) were the predominant menaquinones. The polar lipids were phosphatidylethanolamine, diphosphatidylglycerol and phosphatidylinositol, and no diagnostic whole-cell sugar was detected...
April 6, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29622665/shock-attenuation-in-the-human-lumbar-spine-during-walking-and-running
#18
Eric R Castillo, Daniel E Lieberman
During locomotion, each step generates a shock wave that travels through the body toward the head. Without mechanisms for attenuation, repeated shocks can lead to pathology. Shock attenuation (SA) in the lower limb has been well studied, but little is known about how posture affects SA in the spine. To test the hypothesis that lumbar lordosis (LL) contributes to SA, 27 adults (14 male, 13 female) walked and ran on a treadmill. Two lightweight, tri-axial accelerometers were affixed to the skin overlying T12/L1 and L5/S1...
April 5, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29621584/amaranthus-caudatus-extract-inhibits-the-invasion-of-e-coli-into-uroepithelial-cells
#19
Soumitra Mohanty, Silvia Zambrana, Soizic Dieulouard, Witchuda Kamolvit, Vera Nilsén, Eduardo Gonzales, Claes-Göran Östenson, Annelie Brauner
ETHNOPHARMACOLOGICAL RELEVANCE: Amaranthus caudatus is traditionally used to treat infections. Based on its traditional usage, we investigated the effect of A. caudatus on the bladder epithelial cells in the protection of E. coli infection. MATERIALS AND METHODS: The direct antimicrobial effects of A. caudatus on uropathogenic bacteria were investigated using minimum inhibitory concentration (MIC) assay. Bladder epithelial cell lines T24 and 5637 and uropathogenic E...
April 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29620496/streptacidiphilus-monticola-sp-nov-a-novel-actinomycete-isolated-from-soil
#20
Wei Song, Liping Duan, Liying Jin, Junwei Zhao, Shanwen Jiang, Tianyu Sun, Xiao Wei Guo, Wensheng Xiang, Xiangjing Wang
A novel actinobacterium, designated strain NEAU-SW11T , was isolated from soil collected from Binxian, Heilongjiang province, north China. The isolate was found to have chemical and morphological properties of the genus Streptacidiphilus, with the highest sequence similarities to Streptacidiphilus anmyonensis JCM 16223T (98.1 %), Streptacidiphilus jiangxiensis JCM 12277T (97.8 %), Streptacidiphilus melanogenes JCM 16224T (97.6 %) and Streptacidiphilus rugosus JCM 16225T (97.4 %) and it phylogenetically clustered with these four strains...
April 5, 2018: International Journal of Systematic and Evolutionary Microbiology
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