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https://www.readbyqxmd.com/read/29451437/do-intraoperative-radiographs-predict-final-lumbar-sagittal-alignment-following-single-level-transforaminal-lumbar-interbody-fusion
#1
Khalid M I Salem, Aditya P Eranki, Scott Paquette, Michael Boyd, John Street, Brian K Kwon, Charles G Fisher, Marcel F Dvorak
OBJECTIVE The study aimed to determine if the intraoperative segmental lordosis (as calculated on a cross-table lateral radiograph following a single-level transforaminal lumbar interbody fusion [TLIF] for degenerative spondylolisthesis/low-grade isthmic spondylolisthesis) is maintained at discharge and at 6 months postsurgery. METHODS The authors reviewed images and medical records of patients ≥ 16 years of age with a diagnosis of an isolated single-level, low-grade spondylolisthesis (degenerative or isthmic) with symptomatic spinal stenosis treated between January 2008 and April 2014...
February 16, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29449813/non-nucleotide-agonists-triggering-p2x7-receptor-activation-and-pore-formation
#2
REVIEW
Francesco Di Virgilio, Anna L Giuliani, Valentina Vultaggio-Poma, Simonetta Falzoni, Alba C Sarti
The P2X7 receptor (P2X7R) is a ligand-gated plasma membrane ion channel belonging to the P2X receptor subfamily activated by extracellular nucleotides. General consensus holds that the physiological (and maybe the only) agonist is ATP. However, scattered evidence generated over the last several years suggests that ATP might not be the only agonist, especially at inflammatory sites. Solid data show that NAD + covalently modifies the P2X7R of mouse T lymphocytes, thus lowering the ATP threshold for activation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29444844/the-stomatogastric-nervous-system-of-the-medicinal-leech-its-anatomy-physiology-and-associated-aminergic-neurons
#3
Karen A Mesce, Magda Alania, Quentin Gaudry, Joshua G Puhl
Blood feeding is an essential and signature activity of the medicinal leech species, Hirudo verbana Despite keen interest in understanding the neuronal substrates of this behavior, a major component of the nervous system associated with feeding has remained overlooked. In this study, for the first time, we report on the presence and characteristics of five stomatogastic ganglia (STGs) comprising the visceral stomatogastric nervous system (STN) of the leech. Although Hanke (1948) provided a brief report that a ring of three ganglia (not five) was associated with the cephalic ganglia, this information was never integrated into subsequent neurobiological studies of feeding...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29444339/nursing-intensive-care-satisfaction-scale-nicss-development-and-validation-of-a-patient-centered-instrument
#4
M Romero-García, L de la Cueva-Ariza, Ll Benito-Aracil, T M Lluch-Canut, J Trujols-Albet, M A Martínez-Momblan, M E Juvé-Udina, P Delgado-Hito
AIM: To develop and validate the Nursing Intensive-Care-Satisfaction-Scale to measures satisfaction with nursing care from the critical care patient's perspective. BACKGROUND: Instruments that measure satisfaction with nursing cares have been designed and validated without taking the patient's perspective into consideration. Despite the benefits and advances in measuring satisfaction with nursing care, none instrument is specifically designed to assess satisfaction in intensive care units...
February 14, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29443809/association-between-visual-acuity-and-the-corneal-area-occupied-by-granular-lesions-linear-lesions-or-diffuse-haze-in-patients-with-granular-corneal-dystrophy-type-2
#5
Hong Seok Kim, Tyler Hyungtaek Rim, Tae-Im Kim, Eung Kweon Kim
PURPOSE: In granular corneal dystrophy type 2 (GCD2), corneal deposits containing fragments of transforming growth factor-β-induced protein appear in sequence as granular lesions (GLs), linear lesions (LLs), and diffuse haze (DH). We aimed to investigate the association between visual acuity and age-related changes in lesion types in patients with GCD2. METHODS: We retrospectively evaluated the medical records and slit-lamp photographs of 533 patients (1066 eyes) with genetically confirmed GCD2 (heterozygous)...
February 13, 2018: Cornea
https://www.readbyqxmd.com/read/29442100/predictors-of-deterioration-in-sagittal-balance-following-long-fusion-arthrodesis-to-l5-in-patients-with-adult-scoliosis
#6
Xianda Gao, Linfeng Wang, Changzhi Yan, Yanlong Gao, Yong Shen
BACKGROUND The aim of this study was to identify the predictors of deterioration in sagittal balance in patients with adult scoliosis following long fusion arthrodesis to L5. MATERIAL AND METHODS A retrospective clinical study included 63 patients with adult scoliosis who underwent long fusion arthrodesis to L5, between February 2005 and May 2015. Radiological imaging values included the angle of lumbar lordosis (LL), and the angle of pelvic incidence (PI). The patients were divided into two cohorts, according to the threshold of average loss of sagittal vertical axis (SVA): a cohort with stable sagittal balance (SSB) and a cohort with deteriorated sagittal balance (DSB)...
February 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29440670/characterization-of-conserved-and-novel-micrornas-in-lilium-lancifolium-thunb-by-high-throughput-sequencing
#7
Xiangfeng He, Awraris Getachew Shenkute, Wenhe Wang, Shufa Xu
MicroRNAs (miRNAs) are among the class of noncoding small RNA molecules and play a crucial role in post-transcriptional regulation in plants. Although Lilium is one of the most popular ornamental flowers worldwide, however, there is no report on miRNAs identification. In the present study, therefore, miRNAs and their targets were identified from flower, leaf, bulblet and bulb of Lilium lancifolium Thunb. by high-throughput sequencing and bioinformatics analysis. In this study, a total of 38 conserved miRNAs belonging to 17 miRNA families and 44 novel miRNAs were identified...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439363/effects-of-posture-and-coactivation-on-corticomotor-excitability-of-ankle-muscles
#8
Trisha M Kesar, Steven Eicholtz, Bethany J Lin, Steven L Wolf, Michael R Borich
BACKGROUND: The use of transcranial magnetic stimulation (TMS) to evaluate corticomotor excitability of lower limb (LL) muscles can provide insights about neuroplasticity mechanisms underlying LL rehabilitation. However, to date, a majority of TMS studies have focused on upper limb muscles. Posture-related activation is an important under-investigated factor influencing corticomotor excitability of LL muscles. OBJECTIVE: The purpose of this study was to evaluate effects of posture and background activation on corticomotor excitability of ankle muscles...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29439267/radiation-exposure-during-ureterorenoscopy-and-laser-lithotripsy-an-analysis-of-stone-characteristics
#9
Marios Hadjipavlou, Vincent Lam, Jai Seth, Faqar Anjum, Seshadri Sriprasad
INTRODUCTION AND OBJECTIVES: Stone formers often have a chronic exposure to significant quantities of ionising radiation from radiological investigations and interventions. Predicting radiation exposure would allow the clinician to quantify expected cumulative radiation and find strategies to minimise exposure. We evaluated radiation exposure during ureteroscopy and laser lithotripsy (URS + LL) for a single stone episode and correlated the results to stone characteristics. METHOD: Data was collected retrospectively for all patients undergoing URS + LL in our institution over a 1 year period...
February 13, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29434756/long-term-survival-after-corrective-surgeries-in-two-patients-with-severe-deformities-due-to-roberts-syndrome-a-case-report-and-review-of-the-literature
#10
Jing Zhou, Xiaonan Yang, Xiaolei Jin, Zhenhua Jia, Haibin Lu, Zuoliang Qi
Roberts syndrome (RBS; OMIM 268300) is a rare autosomal recessive disease characterized by retardation before and after birth, cranial and maxillofacial deformities, limb anomalies and intellectual disability. Mutations in the establishment of cohesion 1 homologue 2 (ESCO2) gene on chromosome 8p21.1 have been found to be causative for RBS. We describe two patients with RBS with physical deformities and ll. One is an 8-year-old Yemeni male, and the other is his 13-year-old sister. These patients were diagnosed with RBS and underwent surgeries during their first to third years of life...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433275/influence-of-carcass-weight-on-meat-quality-of-commercial-feedlot-steers-with-similar-feedlot-slaughter-and-post-mortem-management
#11
Babatunde Agbeniga, Edward C Webb
The effects of beef carcass weight on muscle pH/temperature profile and selected meat quality attributes were evaluated. Twenty-six carcasses from light (≤260kg, n=15) and heavy (≥290kg, n=11) feedlot steers were randomly allocated and stimulated with low voltage electrical stimulation (LVES) for 30s at 7min post-mortem (pm). Quality evaluations were carried out on samples from the Longissimus et lumborum (LL) muscle from the left side of each carcass. Heavier carcasses showed faster pH decline and slower (P<0...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430821/alanine-and-lysine-scans-of-the-ll-37-derived-peptide-fragment-kr-12-reveal-key-residues-for-antimicrobial-activity
#12
Sunithi Gunasekera, Taj Muhammad, Adam A Strömstedt, K Johan Rosengren, Ulf Göransson
The human host defence peptide LL-37 is a broad-spectrum antibiotic with immunomodulatory functions. Residues 18-29 in LL-37 have previously been identified as a minimal peptide (KR-12) that retains antibacterial activity with decreased cytotoxicity. In this study, we generated analogues of KR-12 by Ala and Lys scans to identify key elements for activity. These were tested against a panel of human pathogens and for membrane permeabilization on liposomes. Replacements of hydrophobic and cationic residues with Ala were detrimental for antibiotic potency...
February 11, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29430329/-spino-pelvic-sagittal-parameters-in-an-asymptomatic-population-in-argentina
#13
Alfredo Guiroy, Martín Gagliardi, Alfredo Sícoli, Nicolás Gonzalez Masanés, Alejandro Morales Ciancio, Pablo Jalón, Juan José Mezzadri
Objectives: To assess and describe spinal and pelvic sagittal parameters in a series of 100 Argentinian volunteers. Methods: Lateral full-spine X-rays were obtained prospectively from 100 volunteers (30 males and 70 females), average age 34.1 years. All the volunteers were asymptomatic at the time of the study. Full-length left lateral spine radiographs (36'' cassette) were made using Kodak Elite CR equipment. The authors made determinations for the digital X-rays using Surgimap®, version 2...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29428711/2005-2014-trends-of-pm10-source-contributions-in-an-industrialized-area-of-southern-spain
#14
Jiwei Li, Bing Chen, Ana M Sánchez de la Campa, Andrés Alastuey, Xavier Querol, Jesus D de la Rosa
Particulate matter with a diameter of 10 μm or less (PM10) using receptor modelling was determined at an urban (La Linea, LL) and an industrial area (Puente Mayorga, PMY) in Southern Spain with samples collected during 2005-2014. The concentrations of PM10 had been decreasing at both sites in three distinctive periods: 1) the initial PM10 levels approached or exceeded the Spain and EU PM10 annual guidelines of 40 μg/m3 during 2005-2007 at LL and 2005-2009 at PMY; 2) then PM10 dropped by 25%-∼30 μg/m3 during 2008-2011 at LL and during 2010-2011 at PMY; 3) since 2012, the PM10 concentrations gradually decreased to <30 μg/m3...
February 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29427853/effect-of-long-term-chilled-up-to-5%C3%A2-weeks-then-frozen-up-to-12%C3%A2-months-storage-at-two-different-sub-zero-holding-temperatures-on-beef-3-protein-structure-degradation-and-a-marker-of-protein-oxidation
#15
Benjamin W B Holman, Cassius E O Coombs, Stephen Morris, Matthew J Kerr, David L Hopkins
Different chilled (~0.1 °C for up to 5 weeks) then frozen storage (up to 12 months) combinations and two frozen storage holding temperatures (-12 °C and -18 °C) effects on beef M. longissimus lumborum (LL) protein structure degradation and a marker of protein oxidation were tested. Particle size (PS) analysis and protein solubility results found storage combination effects on protein degradation to be significant (P < 0.05), although the influence of frozen holding temperatures was negligible...
February 2, 2018: Meat Science
https://www.readbyqxmd.com/read/29424090/the-host-defense-peptide-ll-37-is-detected-in-human-parotid-and-submandibular-sublingual-saliva-and-expressed-in-glandular-neutrophils
#16
Daniel Svensson, Alexandra Aidoukovitch, Emma Anders, Birgitta Agerberth, Fredrik Andersson, Eva Ekblad, Dan Ericson, Daniel Nebel, Ulrikke Voss, Bengt-Olof Nilsson
The human host defense peptide, LL-37, is an important player in the first line of defense against invading microorganisms. LL-37 and its precursor, hCAP18, have been detected in unstimulated whole saliva but no reports showing hCAP18/LL-37 in isolated, parotid, and/or submandibular/sublingual saliva have been presented. Here, we measured the levels of hCAP18/LL-37 in human parotid and submandibular/sublingual saliva and investigated the expression of hCAP18/LL-37 in parotid and submandibular gland tissue. Parotid and submandibular/sublingual saliva was collected from healthy volunteers, and the levels of hCAP18/LL-37 in saliva were analyzed by dot blot, ELISA, and western blotting...
February 9, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29419717/the-efficacy-of-brace-treatment-for-thoracolumbar-kyphosis-in-patients-with-achondroplasia
#17
Leilei Xu, Yetian Li, Fei Sheng, Chao Xia, Yong Qiu, Zezhang Zhu
STUDY DESIGN: A retrospective study. OBJECTIVES: To evaluate the outcome of brace treatment in the correction of thoracolumbar kyphosis (TLK) for patients with achondroplasia and to determine the factors associated with bracing efficacy. SUMMARY OF BACKGROUND DATA: Brace treatment has been used to correct TLK in patients with achondroplasia. However, there was a paucity of knowledge concerning its effectiveness. METHODS: 33 achondroplasic patients treated by bracing were included in this study...
February 6, 2018: Spine
https://www.readbyqxmd.com/read/29417324/radiological-severity-of-hip-osteoarthritis-in-patients-with-adult-spinal-deformity-the-effect-on-spinopelvic-and-lower-extremity-compensatory-mechanisms
#18
Louis M Day, Edward M DelSole, Bryan M Beaubrun, Peter L Zhou, John Y Moon, Jared C Tishelman, Jonathan M Vigdorchik, Ran Schwarzkopf, Renaud Lafage, Virginie Lafage, Themistocles Protopsaltis, Aaron J Buckland
PURPOSE: Sagittal spinal deformity (SSD) patients utilize pelvic tilt (PT) and their lower extremities in order to compensate for malalignment. This study examines the effect of hip osteoarthritis (OA) on compensatory mechanisms in SSD patients. METHODS: Patients ≥ 18 years with SSD were included for analysis. Spinopelvic, lower extremity, and cervical alignment were assessed on standing full-body stereoradiographs. Hip OA severity was graded by Kellgren-Lawrence scale (0-4)...
February 7, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29417323/georg-schmorl-prize-of-the-german-spine-society-dwg-2017-correction-of-spino-pelvic-alignment-with-relordosing-mono-and-bisegmental-tlif-spondylodesis
#19
Frederick Galla, Dirk Wähnert, Ulf Liljenqvist
INTRODUCTION: A balanced ratio of the main parameters of lumbar lordosis (LL) and pelvic incidence (PI) has high clinical relevance. A postoperative mismatch of LL and PI has been described in the literature to be associated with an inferior clinical outcome and higher postoperative revision rates. The aim of this retrospective, radiological study is to evaluate the magnitude of relordosing in mono-/bisegmental TLIF spondylodesis affecting the spino-pelvic alignment and the main contributing factors...
February 7, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29417322/sagittal-imbalance-treated-with-l5-pedicle-subtraction-osteotomy-with-short-lumbar-fusion-from-l4-to-sacrum-using-four-screws-into-l4-for-enhanced-fixation-two-additional-vertebral-screws-a-technical-note
#20
Kuenzang Wangdi, Bungo Otsuki, Shunsuke Fujibayashi, Shimei Tanida, Kazutaka Masamoto, Shuichi Matsuda
PURPOSE: To report on suggested technique with four screws in a single vertebra (two pedicle screws and two direct vertebral body screws) for enhanced fixation with just one level cranially to a pedicle subtraction osteotomy (PSO). METHODS: A 60-year-old woman underwent L4/5 fusion surgery for degenerative spondylolisthesis. Two years later, she was unable to stand upright even for a short time because of lumbar kyphosis caused by subsidence of the fusion cage and of Baastrup syndrome in the upper lumbar spine [sagittal vertical axis (SVA) of 114 mm, pelvic incidence of 75°, and lumbar lordosis (LL) of 41°]...
February 7, 2018: European Spine Journal
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