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https://www.readbyqxmd.com/read/28644314/prone-or-left-for-colonoscopy-a-randomized-controlled-trial-of-prone-versus-left-sided-starting-position-for-colonoscopy
#1
Nikhil Vergis, Alexander J Scarborough, James A Morris, Jonathan M Hoare
BACKGROUND AND AIMS: Data have emerged supporting the right-lateral starting position in reducing time to cecum and improving patient comfort for minimally sedated colonoscopy. We aimed to test whether prone starting position results in similar advantages in procedure time and patient tolerability in comparison to traditional left-sided starting position. MATERIALS AND METHODS: We conducted a randomized controlled trial in which patients were randomized to begin in either the prone or left-lateral (LL) position...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28643084/influence-of-knockout-of-at4g20990-gene-encoding-%C3%AE-ca4-on-photosystem-ii-light-harvesting-antenna-in-plants-grown-under-different-light-intensities-and-day-lengths
#2
Natalia N Rudenko, Tatyana P Fedorchuk, Daria V Vetoshkina, Elena M Zhurikova, Lyudmila K Ignatova, Boris N Ivanov
Effect of knockout of the At4g20990 gene encoding α-carbonic anhydrase 4 (α-CA4) in Arabidopsis thaliana in plants grown in low light (LL, 80 μmol photons m(-2) s(-1)) or in high light (HL, 400 μmol photons m(-2) s(-1)) under long (LD, 16 h) or short (SD, 8 h) day length was studied. In α-CA4 knockout plants, under all studied conditions, the non-photochemical quenching was lower; the decrease was more pronounced under HL. This pointed to α-CA4 implication in the processes leading to energy dissipation in PSII antenna...
June 22, 2017: Protoplasma
https://www.readbyqxmd.com/read/28641473/co-targeting-intracellular-ph-and-essential-amino-acid-uptake-cooperates-to-induce-cell-death-of-t-all-ll-cells
#3
Véronique Imbert, Marielle Nebout, Didier Mary, Hitoshi Endou, Michael F Wempe, Claudiu T Supuran, Jean-Yves Winum, Jean-François Peyron
Cancer cells reprogram their metabolism to optimize their growth and proliferation in the host microenvironment. For this purpose, they enhance the uptake of extracellular nutrients and deal with the metabolic waste products through the overexpression of numerous membrane proteins including amino-acid transporters (LAT1) and acid-base regulating enzymes, such as carbonic anhydrases (CAs). Here we describe the anti-tumoral effects of a new class of CAXII inhibitors, the glycosyl coumarins on T-ALL/LL cells. These effects appeared to be mediated through inhibition of mTOR/Akt pathway and c-myc downregulation...
June 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28637951/porphyromonas-gingivalis-induced-il-33-down-regulates-hcap-18-ll-37-production-in-human-gingival-epithelial-cells
#4
Hiroyuki Tada, Takamitsu Shimizu, Kenji Matsushita, Haruhiko Takada
hCAP-18/LL-37 is an antimicrobial peptide that is mainly expressed in epithelial cells. Gingival epithelial cells play pivotal roles in antimicrobial defense by expressing hCAP-18/LL-37. Porphyromonas gingivalis is a primary pathogen for chronic periodontitis and produces cysteine proteinase gingipains, which induce proinflammatory cytokines production, leading to enhance inflammatory responses. In contrast, gingipains attenuate immune responses, leading to induce anti-inflammatory responses. In this study, we investigated the ability of gingipains to attenuate P...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28632553/lumbar-retrolisthesis-in-aging-spine-what-are-the-associated-factors
#5
Feng Zhu, Hongda Bao, Zhen Liu, Zezhang Zhu, Shouyu He, Yong Qiu
STUDY DESIGN: A retrospective radiographic study. OBJECTIVE: The aim of this study is to demonstrate that lumbar retrolisthesis serves as an important compensatory mechanism and to identify the possible factor related to lumbar retrolisthesis. SUMMARY OF BACKGROUND DATA: Lumbar instability is one of the common degenerative changes, which presents as 2 radiologic features: anterolisthesis and retrolisthesis. Compared with the extensive studies on anterolisthesis, limit data are available on the characteristics and clinical relevance of lumbar retrolisthesis...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632118/tessaracoccus-arenae-sp-nov-isolated-from-sea-sand
#6
Chutimon Thongphrom, Jong-Hwa Kim, Nagamani Bora, Wonyong Kim
A Gram-stain positive, non-spore-forming, non-motile, facultatively anaerobic bacterial strain, designated CAU 1319T, was isolated from sea sand and the strain's taxonomic position was investigated using a polyphasic approach. Strain CAU 1319T grew optimally at 30 °C and at pH 7.5 in the presence of 2 % (w/v) NaCl. Phylogenetic analysis, based on the 16S rRNA gene sequence, revealed that strain CAU 1319T belongs to the genus Tessaracoccus, and is closely related to Tessaracoccus lapidicaptus IPBSL-7T (similarity 97...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28629493/naumannella-huperziae-sp-nov-an-endophytic-actinobacterium-isolated-from-huperzia-serrata-thunb
#7
Ye Sun, Hua-Hong Chen, Hong-Min Sun, Meng-Jie Ai, Jing Su, Li-Yan Yu, Yu-Qin Zhang
An endophytic, short rod-shaped, non-motile and non-spore-forming actinobacterium, designated strain CPCC 204135T, was isolated from a surface-sterilized medicinal plant, Huperzia serrata (Thunb.), collected from Sichuan Province, south-west China. Strain CPCC 204135T was observed to grow at temperatures between 20 and 37 °C (optimum, 28-32 °C), at pH 6.0-9.0 (optimum, pH 7.0-8.0) and in the presence of 0-9.0 % (w/v) NaCl (optimum, 0-3 %). Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CPCC 204135T belonged to the genus Naumannella, showing the highest level of 16S rRNA gene sequence similarity with Naumannella halotolerans DSM 24323T (97...
June 20, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28629168/assessing-statistically-significant-heavy-metal-concentrations-in-abandoned-mine-areas-via-hot-spot-analysis-of-portable-xrf-data
#8
Sung-Min Kim, Yosoon Choi
To develop appropriate measures to prevent soil contamination in abandoned mining areas, an understanding of the spatial variation of the potentially toxic trace elements (PTEs) in the soil is necessary. For the purpose of effective soil sampling, this study uses hot spot analysis, which calculates a z-score based on the Getis-Ord Gi* statistic to identify a statistically significant hot spot sample. To constitute a statistically significant hot spot, a feature with a high value should also be surrounded by other features with high values...
June 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28622902/a-critical-analysis-of-sagittal-plane-deformity-correction-with-minimally-invasive-adult-spinal-deformity-surgery-a-2-year-follow-up-study
#9
Gregory M Mundis, Jay D Turner, Vedat Deverin, Juan S Uribe, Pierce Nunley, Praveen Mummaneni, Neel Anand, Paul Park, David O Okonkwo, Michael Y Wang, Shay Bess, Adam S Kanter, Richard Fessler, Stacie Nguyen, Behrooz A Akbarnia
INTRODUCTION: Sagittal plane realignment is important to achieve desirable clinical outcomes after adult spinal deformity (ASD) surgery. This study evaluates the impact of minimally invasive (MIS) techniques on sagittal plane alignment and clinical outcomes in ASD patients. METHODS: A retrospective, multi-center review of ASD patients (age ≥18 years, and with one of the following: coronal Cobb ≥20°, sagittal vertical axis [SVA] >5 cm, and/or pelvic tilt >25°), MIS surgery, and four or more levels instrumented...
July 2017: Spine Deformity
https://www.readbyqxmd.com/read/28622430/enterohaemorrhagic-escherichia-coli-produces-outer-membrane-vesicles-as-an-active-defense-system-against-antimicrobial-peptide-ll-37
#10
Akiko Urashima, Ayano Sanou, Hilo Yen, Toru Tobe
Antimicrobial peptides (AMPs) are important components of the innate immune system. Enterohaemorrhagic Escherichia coli (EHEC), a food-borne pathogen causing serious diarrheal diseases, must overcome attack by AMPs. Here, we show that resistance of EHEC against human cathelicidin LL-37, a primary AMP, was enhanced by butyrate, which has been shown to act as a stimulant for the expression of virulence genes. The increase of resistance depended on the activation of the ompT gene, which encodes the outer membrane protease OmpT for LL-37...
June 16, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28622188/differences-in-fundamental-sagittal-pelvic-parameters-based-on-age-sex-and-race
#11
Robert K Merrill, Jun S Kim, Dante M Leven, Joung Heon Kim, Joshua J Meaike, Rachel S Bronheim, Kelly I Suchman, Doug Nowacki, Sunder S Gidumal, Samuel K Cho
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To determine whether age, sex, and race have independent effects on sagittal pelvic parameters. SUMMARY OF BACKGROUND DATA: Pelvic parameters and sagittal balance correlate with health-related quality of life and are important for patient assessment and surgical planning. Age, sex, and race are 3 unalterable patient factors that may influence pelvic morphology. METHODS: We conducted a retrospective review of consecutive adult patients who presented to our radiology practice between 2010 and 2015 and had a standing, lateral lumbosacral radiograph...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28622053/importance-of-sandy-bottoms-in-coral-reefs-to-the-oscillation-of-daily-rhythms-in-the-tropical-wrasse-halichoeres-trimaculatus
#12
Hitomi Ito-Takeuchi, Kai Takahashi, Selma Bouchekioua, Chihiro Yamauchi, Yuki Takeuchi, Sung-Pyo Hur, Young-Don Lee, Akihiro Takemura
Most wrasse species swim during the day and bury themselves in the sandy bottoms of shallow reefs at night. This study aimed to evaluate the importance of sandy bottoms to the day-active/night-inactive rhythmicity of the tropical wrasse Halichoeres trimaculatus. Actogram analysis revealed that fish were active during the photophase and inactive during the scotophase in aquariums with both sandy and bare bottoms. When fish were kept in aquariums with bare bottoms, rhythmicity was maintained under constant dark conditions (DD) but became obscured under constant light conditions (LL), suggesting that a day-active/night-inactive rhythmicity is regulated by the circadian system...
June 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28617048/developmental-patterns-of-child-emotion-dysregulation-as-predicted-by-serotonin-transporter-genotype-and-parenting
#13
Amanda N Noroña, Irene Tung, Steve S Lee, Jan Blacher, Keith A Crnic, Bruce L Baker
Individual differences in emotion regulation are central to social, academic, occupational, and psychological development, and emotion dysregulation (ED) in childhood is a risk factor for numerous developmental outcomes. The present study aimed to (a) describe the developmental trajectory of ED across early childhood (3-6 years) and (b) examine its sensitivity to youth serotonin transporter genotype, positive and negative parenting behaviors, and their interaction. Participants were 99 families in the Collaborative Family Study, a longitudinal study of children with or without developmental delays...
June 15, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28615922/influence-of-circulating-endothelin-1-and-asymmetric-dimethylarginine-on-whole-brain-circulation-time-in-multiple-sclerosis
#14
Lucia Monti, Lucia Morbidelli, Lorenzo Bazzani, Alessandro Rossi
Blood-brain barrier (BBB) breakdown, inflammatory and immune cell activation, and chronic cerebral hypoperfusion are features of multiple sclerosis (MS). The aim is to determine the influence of endothelin-1 (ET1) and asymmetric dimethylarginine (ADMA) on cerebral circulation time (CCT) in patients with MS. In all, 64 patients with MS (39 relapsing-remitting [RR]-MS; 25 secondary progressive [SP]-MS subtype) and 37 controls (C) were studied. Cerebral circulation time was obtained by angiography. Plasmatic ET1 and ADMA were measured by enzyme-linked immunosorbent assay...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28606090/comparative-efficacy-analysis-of-anti-microbial-peptides-ll-37-and-indolicidin-upon-conjugation-with-cnt-in-human-monocytes
#15
Biswaranjan Pradhan, Dipanjan Guha, Krushna Chandra Murmu, Abhinav Sur, Pratikshya Ray, Debashmita Das, Palok Aich
BACKGROUND: Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of microbial pathogens. Reports have proposed that by harnessing innate immune activation, AMPs can regulate pathogen invasion and may control infection. It has been reported that AMPs could be utilized to activate the innate mucosal immune response in order to eliminate pathogenic infections. This way of controlling pathogen infection, by activating host immunity, confers the potential to the select AMPs to alleviate the problem of antibiotic resistance...
June 12, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28605742/endotoxin-exposure-increases-ll-37-but-not-calprotectin-in-healthy-human-airways
#16
Margaretha E Smith, Marit Stockfelt, Sara Tengvall, Peter Bergman, Anders Lindén, Ingemar Qvarfordt
RATIONALE: The antimicrobial peptides (AMPs) LL-37 and calprotectin are important players in the innate immunity of human airways. In patients with diseases characterized by bacterial colonization, the airway concentrations of these AMPs are increased. Less is known about their presence and release patterns in healthy humans. Our aim was to determine whether LL-37 and calprotectin are released after the activation of the innate immune response in the peripheral airways. METHODS: Healthy volunteers underwent exposure to endotoxin and vehicle in contralateral segment bronchi...
June 13, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28602440/-prevalence-of-macrovascular-arterial-involvement-of-the-4%C3%A2-limbs-in-systemic-sclerosis-about-a-case-series-of-14-patients
#17
B Watelet, J Jeancolas, D Lanéelle, B Bienvenu, C Le Hello
INTRODUCTION: Trophic disorders of the extremities are a common complication of systemic sclerosis (SSc), mainly related to microvascular damage. However, SSc seems to be a risk factor for premature athero-thrombotic disease that can affect the peripheral arteries, participate in the occurrence of trophic disorders and promote the occurrence of infectious complications. The objective of this study was to assess the prevalence of arterial disease of the limbs in SSc patients. METHODS: Consecutive inclusions in the context of a multidisciplinary consultation centered on disability of the hand with collection of clinical data [cardiovascular risk factors (CVRF), history of trophic disorders of ischemic origin, peripheral pulse palpation, Allen maneuver the upper (UL) and lower limbs (LL)], and hemodynamic data (flow recorded by Doppler in radial, ulnar, anterior and posterior tibial arteries, and measurement of systolic indices ankles)...
June 8, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28601994/radiologic-features-of-dropped-head-syndrome-in-the-overall-sagittal-alignment-of-the-spine
#18
Kazuki Hashimoto, Hiroshi Miyamoto, Terumasa Ikeda, Masao Akagi
PURPOSE: Dropped head syndrome (DHS) is a rare clinical entity which is defined as a chin-on-chest deformity in the standing or sitting position, resulting from sagittal imbalance of the cervical region. The purpose of the present study was to clarify the radiologic features of DHS in the overall sagittal alignment of the spine. We also investigated the changes in sagittal alignment after correction surgery for DHS. METHODS: Twenty DHS patients [1 male and 19 female, with an average age of 78...
June 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28601465/evaluation-of-an-automated-milk-leukocyte-differential-test-and-the-california-mastitis-test-for-detecting-intramammary-infection-in-early-and-late-lactation-quarters-and-cows
#19
S M Godden, E Royster, J Timmerman, P Rapnicki, H Green
Study objectives were to (1) describe the diagnostic test characteristics of an automated milk leukocyte differential (MLD) test and the California mastitis test (CMT) to identify intramammary infection (IMI) in early- (EL) and late-lactation (LL) quarters and cows when using 3 different approaches to define IMI from milk culture, and (2) describe the repeatability of MLD test results at both the quarter and cow level. Eighty-six EL and 90 LL Holstein cows were sampled from 3 Midwest herds. Quarter milk samples were collected for a cow-side CMT test, milk culture, and MLD testing...
June 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28598900/interleaved-mapping-of-temperature-and-longitudinal-relaxation-rate-to-monitor-drug-delivery-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-induced-hyperthermia
#20
Esther Kneepkens, Edwin Heijman, Jochen Keupp, Steffen Weiss, Klaas Nicolay, Holger Grüll
OBJECTIVES: Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively to a stable, elevated temperature and a well-suited method to induce local hyperthermia (41°C-43°C) in deep-seated tissues. Magnetic Resonance (MR) imaging provides therapy planning on anatomical images and offers temperature feedback based on near-real-time MR thermometry. Although constant acquisition of MR thermometry data is crucial to ensure prolonged hyperthermia, it limits the freedom to perform measurements of other MR parameters, which are of interest during hyperthermia treatments...
June 8, 2017: Investigative Radiology
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