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https://www.readbyqxmd.com/read/28323692/hyperlordosis-is-associated-with-facet-joint-pathology-at-the-lower-lumbar-spine
#1
Thorsten Jentzsch, James Geiger, Matthias A König, Clément M L Werner
STUDY DESIGN: A retrospective study. OBJECTIVE: Our study opted to clarify the remaining issues of lumbar lordosis (LL) with regard to (1) its physiological values, (2) age, (3) sex, and (4) facet joint (FJ) arthritis and orientation using computed tomography (CT) scans. SUMMARY OF BACKGROUND DATA: Recent studies have questioned whether LL really decreases with age, but study sample sizes have been rather small and mostly been based on x-rays...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28316148/ablation-of-complex-fractionated-electrograms-with-or-without-additional-linear-lesions-for-persistent-atrial-fibrillation-the-adline-trial
#2
Sonia Ammar-Busch, Felix Bourier, Tilko Reents, Verena Semmler, Marta Telishevska, Susanne Kathan, Monika Hofmann, Gabriele Hessling, Isabel Deisenhofer
BACKGROUND: For persistent atrial fibrillation (AF) ablation, different strategies including complex fractionated atrial electrograms (CFAE) ablation and linear lesions (LL) have been used in addition to pulmonary vein isolation (PVI). However, it is still a matter of debate if extended substrate modification improves long-term outcome. The aim of this study was to determine the benefit of LL in addition to PVI and CFAE ablation regarding freedom from arrhythmia recurrence in patients with persistent AF...
March 18, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28315742/association-of-nitric-oxide-synthase2-gene-polymorphisms-with-leprosy-reactions-in-northern-indian-population
#3
Amit Dubey, Sanjay Kumar Biswas, Ekata Sinha, Joy Kumar Chakma, Raj Kamal, Mamta Arora, Harish Sagar, Mohan Natarajan, Sameer S Bhagyawant, Keshar Kunja Mohanty
The pathogen Mycobacterium leprae causes leprosy that affects mainly skin and nerves. Polymorphisms of certain genes are substantiated to be associated with the susceptibility/resistance to leprosy. The present investigation addressed the association of Nitric Oxide Synthase2 gene polymorphisms and leprosy in a population from northern part of India. A total of 323 leprosy cases and 288 healthy controls were genotyped for four NOS2 promoter variants (rs1800482, rs2779249, rs8078340 and rs2301369) using FRET technology in Real Time PCR...
March 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28306640/cervical-alignment-variations-in-different-postures-and-predictors-of-normal-cervical-kyphosis-a-new-understanding
#4
Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Chengyuan Gordon Wong, Kimberly-Anne Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
STUDY DESIGN: Prospective comparative study OBJECTIVE.: To predict physiological alignment of the cervical spine and study its morphology in different postures. SUMMARY OF BACKGROUND DATA: There is increasing evidence that normal cervical spinal alignment may vary from lordosis to neutral to kyphosis, or form S-shaped or reverse S-shaped curves. METHODS: Standing, erect sitting and natural sitting whole spine radiographs were obtained from 26 consecutive patients without cervical spine pathology...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28306639/defining-the-role-of-the-lower-limbs-in-compensating-for-sagittal-malalignment
#5
Renaud Lafage, Barthelemy Liabaud, Bassel G Diebo, Jonathan H Oren, Shaleen Vira, Sébastien Pesenti, Themistocles S Protopsaltis, Thomas J Errico, Frank J Schwab, Virginie Lafage
STUDY DESIGN: Retrospective review OBJECTIVE.: Investigate the role of lower limbs compensation with progressive sagittal malalignment SUMMARY OF BACKGROUND DATA.: While lower limb compensatory mechanisms are an established response to progressive sagittal malalignment, their specific role and potential impact on surgical planning has not been evaluated. METHODS: Single center retrospective review of full body xrays was performed in patients >20 yrs. Parameters were measured with dedicated software...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28303384/spinopelvic-parameter-changes-and-low-back-pain-improvement-due-to-femoral-neck-anteversion-in-patients-with-severe-unilateral-primary-hip-osteoarthritis-undergoing-total-hip-replacement
#6
Andrea Piazzolla, Giuseppe Solarino, Davide Bizzoca, Viola Montemurro, Pedro Berjano, Claudio Lamartina, Biagio Moretti
PURPOSE: The study of the interrelation between hip and spine disorders is gaining increasing importance in the last years, but the link between Hip Osteoarthritis (HOA) and Low Back Pain (LBP) remains still unclear. Aim of the study is to assess the relationship between Femoral Neck Anteversion (FNA), LBP, and spinopelvic parameters in patients undergoing Total Hip Replacement (THR) for unilateral severe primary HOA. MATERIALS AND METHODS: 91 patients were recruited...
March 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28300046/final-year-nursing-students-in-nigeria-how-knowledgeable-and-prepared-are-they-to-offer-medical-care-to-patients-with-chronic-kidney-disease
#7
Chimezie Godswill Okwuonu, Hannah Sylvanus Kanu, Ojeh-Oziegbe Odigie
BACKGROUND: Nurses play an important role in the management of chronic kidney disease (CKD) patients at primary, secondary, and tertiary levels of care. In other to perform their functions, it is pertinent that they have a good understanding of kidney functions and CKD. We do not know if the current educational curriculum prepares them adequately for this role. AIM: To assess the knowledge level of kidney functions and diseases among final year nursing students in Abia State Nigeria...
January 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28299939/kilobase-pair-chromatin-fiber-contacts-promoted-by-living-system-like-dna-linker-length-distributions-and-nucleosome-depletion
#8
Gavin D Bascom, Taejin Kim, Tamar Schlick
While genome-wide chromosomal contact maps are available for a wide range of cell lines, fiber configurations on the kilobase (kb) chromatin level are largely unknown. Of particular interest is to understand how long-range contacts form and are related to gene regulation. It is believed that nucleosome placement, or linker-length patterns, in chromatin have evolved to yield specific spatial features in chromatin fibers. Here we examine by mesoscale model- ing how such long-range contacts and looping depend on DNA linker length values between successive nucleosomes...
March 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28299584/combined-molecular-docking-and-qsar-study-of-fused-heterocyclic-herbicide-inhibitors-of-d1-protein-in-photosystem-ii-of-plants
#9
Simona Funar-Timofei, Ana Borota, Luminita Crisan
Cinnoline, pyridine, pyrimidine, and triazine herbicides were found be inhibitors of the D1 protein in photosystem II (D1 PSII) electron transport of plants. The photosystem II inhibitory activity of these herbicides, expressed by experimental [Formula: see text] values, was modeled by a docking and quantitative structure-activity relationships study. A conformer ensemble for each of the herbicide structure was generated using the MMFF94s force field. These conformers were further employed in a docking approach, which provided new information about the rational "active conformations" and various interaction patterns of the herbicide derivatives with D1 PSII...
March 16, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28298400/antimicrobial-peptide-levels-are-linked-to-airway-inflammation-bacterial-colonisation-and-exacerbations-in-chronic-obstructive-pulmonary-disease
#10
Louise J P Persson, Marianne Aanerud, Jon A Hardie, Roy Miodini Nilsen, Per S Bakke, Tomas M Eagan, Pieter S Hiemstra
Antimicrobial peptides (AMPs) are effectors of host defence against infection, inflammation and wound repair. We aimed to study AMP levels in stable chronic obstructive pulmonary disease (COPD) and during acute exacerbations of COPD (AECOPD), and to examine their relation to clinical parameters and inflammatory markers.The 3-year Bergen COPD Cohort Study included 433 COPD patients and 325 controls. Induced sputum was obtained and analysed for levels of the AMPs human cathelicidin (hCAP18/LL-37) and secretory leukocyte protease inhibitor (SLPI), and for the inflammatory markers interleukin (IL)-8, IL-6 and tumour necrosis factor-α (TNF-α) using immunoassays...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28297725/rearing-light-intensity-affects-inner-retinal-pathology-in-a-mouse-model-of-x-linked-retinoschisis-but-does-not-alter-gene-therapy-outcome
#11
Dario Marangoni, Zeng Yong, Sten Kjellström, Camasamudram Vijayasarathy, Paul A Sieving, Ronald A Bush
Purpose: To test the effects of rearing light intensity on retinal function and morphology in the retinoschisis knockout (Rs1-KO) mouse model of X-linked retinoschisis, and whether it affects functional outcome of RS1 gene replacement. Methods: Seventy-six Rs1-KO mice were reared in either cyclic low light (LL, 20 lux) or moderate light (ML, 300 lux) and analyzed at 1 and 4 months. Retinal function was assessed by electroretinogram and cavity size by optical coherence tomography...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28295807/interaction-of-melatonin-and-gonadotropin-inhibitory-hormone-on-the-zebrafish-brain-pituitary-reproductive-axis
#12
Thangal Yumnamcha, Zeeshan Ahmad Khan, Chongtham Rajiv, Sijagurumayum Dharmajyoti Devi, Gopinath Mondal, Haobijam Sanjita Devi, Rupjyoti Bharali, Asamanja Chattoraj
Circadian cycles and photoperiod are known to influence reproductive physiology in several animals. Neuropeptides, such as gonadotropin-inhibitory hormone (GNIH) and gonadotropin-releasing hormone (GNRH), are influenced by melatonin in birds and mammals. The present study demonstrates the role of melatonin in oocyte maturation in the zebrafish (Danio rerio), via the brain-pituitary-reproductive axis, under different photic conditions. Melatonin was significantly higher both in the whole brain and ovary under continuous dark (DD) compared to continuous light (LL) conditions...
March 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28291409/association-between-bicortical-screw-fixation-at-upper-instrumented-vertebra-and-risk-for-upper-instrumented-vertebra-fracture
#13
Young-Seop Park, Seung-Jae Hyun, Ho Yong Choi, Ki-Jeong Kim, Tae-Ahn Jahng
OBJECTIVE The aim of this study was to investigate the risk of upper instrumented vertebra (UIV) fractures associated with UIV screw fixation (unicortical vs bicortical) and polymethylmethacrylate (PMMA) augmentation after adult spinal deformity surgery. METHODS A single-center, single-surgeon consecutive series of adult patients who underwent lumbar fusion for ≥ 4 levels (that is, the lower instrumented vertebra at the sacrum or pelvis and the UIV of the thoracolumbar spine [T9-L2]) were retrospectively reviewed...
March 3, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28291378/magnetic-resonance-spectroscopic-analysis-of-multifidus-muscles-lipid-content-and-association-with-spino-pelvic-malalignment-in-chronic-low-back-pain
#14
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Mitsunori Yoshimoto, Yoshinori Terashima, Toshihiko Yamashita
OBJECTIVE: To analyze intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) of the multifidus muscle (Mm) using MR spectroscopy (MRS) in chronic low back pain (CLBP) and control groups and to identify correlations with spino-pelvic alignment. METHODS: Forty (16 males, 24 females; mean age, 62.9 ± 1.9 years) patients whose visual analog scale scores were >30 mm for CLBP were included. Further, 40 control participants matched with the CLBP group subjects by sample size, gender and age (17 males, 23 females; mean age, 65...
March 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28291238/polymorphisms-of-5-htt-lpr-and-gn%C3%AE-3-825c-t-and-response-to-antidepressant-treatment-in-functional-dyspepsia-a-study-from-the-functional-dyspepsia-treatment-trial
#15
Yuri A Saito, G Richard Locke, Ann E Almazar, Ernest P Bouras, Colin W Howden, Brian E Lacy, John K DiBaise, Charlene M Prather, Bincy P Abraham, Hashem B El-Serag, Paul Moayyedi, Linda M Herrick, Lawrence A Szarka, Michael Camilleri, Frank A Hamilton, Cathy D Schleck, Katherine E Tilkes, Alan R Zinsmeister, Nicholas J Talley
OBJECTIVES: The Functional Dyspepsia Treatment Trial reported that amitriptyline (AMI) was associated with adequate relief of functional dyspepsia (FD) symptoms, but the pharmacogenetics of antidepressant response in FD are not known. GNβ3 825C>T CC genotype has been previously linked to FD and TT genotype to antidepressant response in depression. The ss genotype of the 5-HTT LPR variant of the serotonin transporter gene (SLC6A4) has been linked to selective serotonin reuptake inhibitor (SSRI) response...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28288070/novel-synthetic-host-defense-peptide-protects-against-organ-injury-dysfunction-in-a-rat-model-of-severe-hemorrhagic-shock
#16
Noriaki Yamada, Lukas B Martin, Elisabeth Zechendorf, Gareth S D Purvis, Fausto Chiazza, Barbara Varrone, Massimo Collino, Joanna Shepherd, Lena Heinbockel, Thomas Gutsmann, Wilmar Correa, Klaus Brandenburg, Gernot Marx, Tobias Schuerholz, Karim Brohi, Christoph Thiemermann
OBJECTIVE: To evaluate (1) levels of the host-defense/antimicrobial peptide LL-37 in patients with trauma and hemorrhagic shock (HS) and (2) the effects of a synthetic host-defense peptide; Pep19-4LF on multiple organ failure (MOF) associated with HS. BACKGROUND: HS is a common cause of death in severely injured patients. There is no specific therapy that reduces HS-associated MOF. METHODS: (1) LL-37 was measured in 47 trauma/HS patients admitted to an urban major trauma center...
March 10, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28287937/multimodality-imaging-findings-in-carcinoid-tumors-a-head-to-toe-spectrum
#17
Ameya Jagdish Baxi, Kedar Chintapalli, Amol Katkar, Carlos S Restrepo, Sonia L Betancourt, Abhijit Sunnapwar
Carcinoid tumors are a rare biologically heterogeneous group of neuroendocrine tumors with a spectrum ranging from benign indolent to aggressive metastatic tumors. They belong to the category of amine precursor uptake and decarboxylase tumors, or apudomas. The most common sites for primary locations are the gastrointestinal and respiratory tracts; however, any organ can be involved. The clinical presentation depends on location, aggressiveness, production of biologically active amines and peptides, paraneoplastic syndromes, and tendency for metastasis...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28282452/sp-ll-37-human-antimicrobial-peptide-enhances-disease-resistance-in-transgenic-rice
#18
In Hye Lee, Yu-Jin Jung, Yong Gu Cho, Ill Sup Nou, Md Amdadul Huq, Franz Marielle Nogoy, Kwon-Kyoo Kang
Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus. We now demonstrate in this study how signal peptide LL-37 (SP-LL-37) can be used in rice resistance against bacterial leaf blight and blast. We synthesized LL-37 peptide and subcloned in a recombinant pPZP vector with pGD1 as promoter. SP-LL-37 was introduced into rice plants by Agrobacterium mediated transformation. Stable expression of SP-LL-37 in transgenic rice plants was confirmed by RT-PCR and ELISA analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28279936/resilience-theory-incorporated-into-urban-wastewater-systems-management-state-of-the-art
#19
REVIEW
P Juan-García, D Butler, J Comas, G Darch, C Sweetapple, A Thornton, Ll Corominas
Government bodies, utilities, practitioners, and researchers have growing interest in the incorporation of resilience into wastewater management. Since resilience is a multidisciplinary term, it is important to review what has been achieved in the wastewater sector, and describe the future research directions for the forthcoming years. This work presents a critical review of studies that deal with resilience in the wastewater treatment sector, with a special focus on understanding how they addressed the key elements for assessing resilience, such as stressors, system properties, metrics and interventions to increase resilience...
February 20, 2017: Water Research
https://www.readbyqxmd.com/read/28277741/characterization-and-complementation-of-a-chlorophyll-less-dominant-mutant-gl1-in-lagerstroemia-indica
#20
Shu'an Wang, Peng Wang, Lulu Gao, Rutong Yang, Linfang Li, Enliang Zhang, Qing Wang, Ya Li, Zengfang Yin
Crape myrtle (Lagerstroemia indica) is a woody ornamental plant popularly grown because of its long-lasting, midsummer blooms and beautiful colors. The GL1 dominant mutant is the first chlorophyll-less mutant identified in crape myrtle. It was obtained from a natural yellow leaf bud mutation. We previously revealed that leaf color of the GL1 mutant is affected by light intensity. However, the mechanism of the GL1 mutant on light response remained unclear. The acclimation response of mutant and wild-type (WT) plants was assessed in a time series after transferring from low light (LL) to high light (HL) by analyzing chlorophyll synthesis precursor content, photosynthetic performance, and gene expression...
March 9, 2017: DNA and Cell Biology
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