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Xuehui Wu, Huizeng Sun, Mingyuan Xue, Diming Wang, Le Luo Guan, Jianxin Liu
Milk yield (MY) and milk protein (MP) content are crucial milk performance traits of dairy cows that directly affect the dairy profits. This study first proposed milk protein yield (MPY) by considering MY and MP content together. Forty multiparous cows were selected from the 348 Holstein dairy cows, which fed the same diet under the same management condition, to investigate the serum metabolome profiles and to identify key metabolites associated with MPY. Among them, 20 cows with a higher MPY (MY > 34...
June 15, 2018: Journal of Proteomics
C Kachulis, K Abe, C Bronner, Y Hayato, M Ikeda, K Iyogi, J Kameda, Y Kato, Y Kishimoto, Ll Marti, M Miura, S Moriyama, M Nakahata, Y Nakano, S Nakayama, Y Okajima, A Orii, G Pronost, H Sekiya, M Shiozawa, Y Sonoda, A Takeda, A Takenaka, H Tanaka, S Tasaka, T Tomura, R Akutsu, T Kajita, K Kaneyuki, Y Nishimura, K Okumura, K M Tsui, L Labarga, P Fernandez, F D M Blaszczyk, J Gustafson, E Kearns, J L Raaf, J L Stone, L R Sulak, S Berkman, S Tobayama, M Goldhaber, M Elnimr, W R Kropp, S Mine, S Locke, P Weatherly, M B Smy, H W Sobel, V Takhistov, K S Ganezer, J Hill, J Y Kim, I T Lim, R G Park, A Himmel, Z Li, E O'Sullivan, K Scholberg, C W Walter, T Ishizuka, T Nakamura, J S Jang, K Choi, J G Learned, S Matsuno, S N Smith, J Amey, R P Litchfield, W Y Ma, Y Uchida, M O Wascko, S Cao, M Friend, T Hasegawa, T Ishida, T Ishii, T Kobayashi, T Nakadaira, K Nakamura, Y Oyama, K Sakashita, T Sekiguchi, T Tsukamoto, K E Abe, M Hasegawa, A T Suzuki, Y Takeuchi, T Yano, T Hayashino, T Hiraki, S Hirota, K Huang, M Jiang, K E Nakamura, T Nakaya, B Quilain, N D Patel, R A Wendell, L H V Anthony, N McCauley, A Pritchard, Y Fukuda, Y Itow, M Murase, F Muto, P Mijakowski, K Frankiewicz, C K Jung, X Li, J L Palomino, G Santucci, C Vilela, M J Wilking, C Yanagisawa, S Ito, D Fukuda, H Ishino, A Kibayashi, Y Koshio, H Nagata, M Sakuda, C Xu, Y Kuno, D Wark, F Di Lodovico, B Richards, R Tacik, S B Kim, A Cole, L Thompson, H Okazawa, Y Choi, K Ito, K Nishijima, M Koshiba, Y Totsuka, Y Suda, M Yokoyama, R G Calland, M Hartz, K Martens, C Simpson, Y Suzuki, M R Vagins, D Hamabe, M Kuze, T Yoshida, M Ishitsuka, J F Martin, C M Nantais, H A Tanaka, A Konaka, S Chen, L Wan, Y Zhang, R J Wilkes, A Minamino
A search for boosted dark matter using 161.9 kt yr of Super-Kamiokande IV data is presented. We search for an excess of elastically scattered electrons above the atmospheric neutrino background, with a visible energy between 100 MeV and 1 TeV, pointing back to the Galactic center or the Sun. No such excess is observed. Limits on boosted dark matter event rates in multiple angular cones around the Galactic center and Sun are calculated. Limits are also calculated for a baseline model of boosted dark matter produced from cold dark matter annihilation or decay...
June 1, 2018: Physical Review Letters
Guosheng Qu, Carol Lyn Piazza, Dorie Smith, Marlene Belfort
Group II introns are mobile ribozymes that are rare in bacterial genomes, often cohabiting with various mobile elements, and seldom interrupting housekeeping genes. What accounts for this distribution has not been well understood. Here, we demonstrate that Ll.LtrB, the group II intron residing in a relaxase gene on a conjugative plasmid from Lactococcus lactis , inhibits its host gene expression and restrains the naturally cohabiting mobile element from conjugative horizontal transfer. We show that reduction in gene expression is mainly at the mRNA level, and results from the interaction between exon-binding sequences (EBSs) in the intron and intron-binding sequences (IBSs) in the mRNA...
June 15, 2018: ELife
Yasaman Rafat, Ryan A Stevenson
Recent studies have provided evidence for both a positive and a negative effect of orthography on second language speech learning. However, not much is known about whether orthography can trigger a McGurk-like effect (McGurk & MacDonald, 1976) in second language speech learning. This study examined whether exposure to auditory and orthographic input may lead to a McGurk-like effect in naïve English-speaking participants learning a second language with Spanish phonology and orthography. Specifically, it reports on (a) production of non-target-like combinations such as [lj] as in [poljo] for <pollo>-[pojo], where the auditory Spanish [j] and the first language English [l] that correspond to the shared digraph <ll> are integrated, and (b) fusion quantified in terms of [z] devoicing such as [z̥apito] for <zapito>-[zapito]...
June 1, 2018: Language and Speech
Luming Yang, Hanqiang Liu, Jianyu Zhao, Yupeng Pan, Siyuan Cheng, Calvin D Lietzow, Changlong Wen, Xiaolan Zhang, Yiqun Weng
Plants employ tight genetic control to integrate intrinsic growth signals and environmental cues to enable organ growth to a defined size. Many genes contributing to cell proliferation and/or cell expansion and consequently organ size control have been identified, but the regulatory pathways are poorly understood. Here we have characterized a cucumber littleleaf (ll) mutant which exhibits smaller organ sizes but more lateral branches than the wildtype. The small organ size in ll was due to a reduction of both cell number and cell size...
June 14, 2018: Plant Journal: for Cell and Molecular Biology
Feng-Ying Huang, Jing Lei, Yan Sun, Fei Yan, Bin Chen, Liming Zhang, Zhuoxuan Lu, Rong Cao, Ying-Ying Lin, Cai-Chun Wang, Guang-Hong Tan
Immunogenic cell death (ICD) is a specific kind of cell death that stimulates the immune system to combat cancer cells. Ultrasound (US)-controlled targeted release of drugs by liposome-microbubble complexes is a promising approach due to its non-invasive nature and visibility through ultrasound imaging. However, it is not known whether this approach can enhance ICD induced by drugs, such as doxorubicin. Herein, we prepared a doxorubicin-liposome-microbubble complex (MbDox), and the resultant MbDox was then characterized and tested for US-controlled release of Dox (MbDox+US treatment) to enhance the induction of ICD in LL/2 and CT26 cancer cells and in syngeneic murine models...
2018: Oncoimmunology
Renata Suellen Galvão da Silva-Costa, Andressa Eveline de Lima Ribeiro, Isauremi Vieira de Assunção, Raimundo Fernandes de Araújo Júnior, Aurigena Antunes de Araújo, Gerlane Coelho Bernardo Guerra, Boniek Castillo Dutra Borges
OBJECTIVES: To study the intensity of inflammatory infiltrate and production of interleukin-1β (ll-1β), tumor necrosis factor-β (TNF-β), fibroblast growth factor-2 (FGF-2), glutathione peroxidase (GPX), and osteocalcin in response to in-office tooth bleaching in rats. MATERIAL AND METHODS: Twenty male Wistar rats were randomized into four groups (n=5) according to the received treatment (tooth bleaching or no treatment - control) and the period of euthanasia after treatment (24 h or 10 days)...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
P S Hosford, V Mosienko, K Kishi, G Jurisic, K Seuwen, B Kinzel, M G Ludwig, J A Wells, I N Christie, L Koolen, A P Abdala, B H Liu, A V Gourine, A G Teschemacher, S Kasparov
Information on the distribution and biology of the G-protein coupled receptor 4 (GPR4) in the brain is limited. It is currently thought that GPR4 couples to Gs proteins and may mediate central respiratory sensitivity to CO2 . Using a knock-in mouse model, abundant GPR4 expression was detected in the cerebrovascular endothelium and neurones of dorsal raphe, retro-trapezoidal nucleus locus coeruleus and lateral septum. A similar distribution was confirmed using RNAscope in situ hybridisation. In HEK293 cells, overexpressing GPR4, it was highly constitutively active at neutral pH with little further increase in cAMP towards acidic pH...
June 9, 2018: Neuropharmacology
Saba Pasha, Brice Ilharreborde, Keith Baldwin
STUDY DESIGN: Systematic review and meta-analysis OBJECTIVE.: To determine the differences in the sagittal spinopelvic parameters between the non-scoliotic controls, pre-operative, and different time points post-operative in Lenke 1 and 5 adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: The post-operative changes in the sagittal profile of Lenke 1 and 5 AIS at varying time points after posterior spinal fusion (PSF) has not been rigorously demonstrated; studies performed have had conflicting results...
June 8, 2018: Spine
Junfeng Zhang, Yunsheng Zhang, Lin Cheng, Chunlei Li, Lei Dai, Hui Zhang, Fenglian Yan, Hui Shi, Guanjun Dong, Zhaochen Ning, Wei Xu, Chuanping Si, Hongxin Deng, Huabao Xiong
Cancer stem cells (CSCs) play important roles in tumor initiation, metastasis, and progression. They are also mainly responsible for high treatment failure rates. Identification and characterization of CSCs are crucial for facilitating the detection, prevention, or therapy of cancer. Great efforts have been paid to develop an effective method and the ideal method for CSCs research is still in the going. In our study, we created an ultra-low concentration of serum and non-adhesive (ULCSN) culture system to enrich CSCs from murine lewis lung cancer cell line LL/2 with cell spheres structure and characterize the LL/2 CSCs properties...
2018: American Journal of Translational Research
Soufiane Ghailane, Houssam Bouloussa, Vincent Challier, Claudio Vergari, Go Yoshida, Ibrahim Obeid, Louis Boissière, Jean-Marc Vital, Simon Mazas, Pierre Coudert, Olivier Gille
STUDY DESIGN: Inter- and intraobserver reliability study. OBJECT: To assess the reliability of a new radiographic classification of degenerative spondylolisthesis of the lumbar spine (DSLS). SUMMARY OF BACKGROUND DATA: DSLS is a common cause of chronic low back and leg pain in adults. To this date, there is no consensus for a comprehensive analysis of DSLS. The reliability of a new DSLS classification system based on sagittal alignment was assessed...
July 2018: Spine Deformity
A C Rienmüller, S M Krieg, F A Schmidt, E L Meyer, B Meyer
BACKGROUND CONTEXT: The concept of dynamic stabilization (DS) of the lumbar spine for treatment of degenerative instability has been introduced almost two decades ago. DS follows the principle of controlling movement in the coronal plane by providing load transfer of the spinal segment without fusion and at the same time reducing side effects such as adjacent segment disease (ASD). So far only little is known about revision rates after DS due to adjacent segment disease (ASD) and screw loosening (SL)...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
Mengmeng Yu, Zhigang Lu, Wenbin Li, Meng Wei, Jing Yan, Jiayin Zhang
AIMS: To study the diagnostic performance of the ratio of Duke jeopardy score (DJS) to the minimal lumen diameter (MLD) at coronary computed tomographic angiography (CCTA) and machine learning based CT-FFR for differentiating functionally significant from insignificant lesions, with reference to fractional flow reserve (FFR). METHODS AND RESULTS: Patients who underwent both coronary CTA and FFR measurement at invasive coronary angiography (ICA) within 2 weeks were retrospectively included in our study...
August 15, 2018: International Journal of Cardiology
Francis G J Longford, Jonathan W Essex, Chris-Kriton Skylaris, Jeremy G Frey
We present an unexpected finite size effect affecting interfacial molecular simulations that is proportional to the width-to-surface-area ratio of the bulk phase Ll /A. This finite size effect has a significant impact on the variance of surface tension values calculated using the virial summation method. A theoretical derivation of the origin of the effect is proposed, giving a new insight into the importance of optimising system dimensions in interfacial simulations. We demonstrate the consequences of this finite size effect via a new way to estimate the surface energetic and entropic properties of simulated air-liquid interfaces...
June 7, 2018: Journal of Chemical Physics
E Capozzi, S Aureli, V Minicozzi, G C Rossi, F Stellato, S Morante
One of the greatest merit of the use of radiopeptides in oncology is their selectivity which, however, brings about the drawback that each radiopeptide is specific for a given tumor type. To overcome this problem the direction currently taken in drug design is that of radiolabelling peptide hormones (or their analogues), relying on their intrinsic ability to bind to specific receptors in precise areas of the human body, at the cost, however, of a poor selectivity against healthy cells. We present here an extensive Molecular Dynamics study of a promising alternative inspired by the mechanism through which antimicrobial peptides interact with the negatively charged bacterial membranes...
June 5, 2018: Biochimica et Biophysica Acta
Samreen Jatana, Craig R Homer, Maria Madajka, András K Ponti, Amrita Kabi, Francis Papay, Christine McDonald
Multidrug-resistant bacterial strains are a rapidly emerging healthcare threat; therefore it is critical to develop new therapies to combat these organisms. Prior antibacterial strategies directly target pathogen growth or viability. Host-directed strategies to increase antimicrobial defenses may be an effective alternative to antibiotics and reduce development of resistant strains. In this study, we demonstrated the efficacy of a pyrimidine synthesis inhibitor, N-phosphonacetyl-L-aspartate (PALA), to enhance clearance of methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Acinetobacter baumannii strains by primary human dermal fibroblasts in vitro...
June 7, 2018: Scientific Reports
Ye He, Yangyang Zhang, Xinkun Shen, Bailong Tao, Ju Liu, Zhang Yuan, Kaiyong Cai
Bacterial infection commonly occurs in clinical settings when the procedure involves a medical implant. Thus, the fabrication of antimicrobial medical materials has attracted much attention in recent years. To improve the antibacterial properties of titanium (Ti)-based biomedical materials, surface microporous structures, with antimicrobial peptide coatings, were employed in this study. Native Ti substrates were endowed with a certain level of antibacterial activity after treatment with the micro-arc oxidation (MAO)...
May 31, 2018: Colloids and Surfaces. B, Biointerfaces
Eunah Suhng, Bo Hee Kim, You Won Choi, Hae Young Choi, Hyunjin Cho, Ji Yeon Byun
BACKGROUND: Rosacea is one of the most common dermatoses of adults. Although the detailed pathophysiology remains unknown, it is thought that rosacea is caused by a consistently aberrant, innate immune response, and that LL-37 plays an important role. However, involvement of the inflammatory cytokine IL-33 has not yet been studied. OBJECTIVES: We explored the role played by IL-33 in the pathophysiology of rosacea. METHODS: First, we immunohistochemically evaluated the expression of IL-33 and its receptor (ST2) in rosacea skin...
June 6, 2018: Experimental Dermatology
Thomas J Buell, Jeffrey P Mullin, James H Nguyen, Davis G Taylor, Juanita Garces, Marcus D Mazur, Avery L Buchholz, Mark E Shaffrey, Chun-Po Yen, Christopher I Shaffrey, Justin S Smith
Proximal junctional kyphosis (PJK) is a common problem after multilevel spine instrumentation for adult spinal deformity. Various anti-PJK techniques such as junctional tethers for ligamentous augmentation have been proposed. We present an operative video demonstrating technical nuances of junctional tether "weave" application. A 70-yr-old male with prior L2-S1 instrumented fusion presented with worsening back pain and posture. Imaging demonstrated pathological loss of lumbar lordosis (flat back deformity), proximal junctional failure, and pseudarthrosis...
June 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
Kirsten Koehorst-Ter Huurne, Catharina Gm Groothuis-Oudshoorn, Paul Dlpm vanderValk, Kris Ll Movig, Job van der Palen, Marjolein Brusse-Keizer
Aim: The aim of this study was to analyze the association between therapy adherence to inhaled corticosteroids (ICSs) and tiotropium on the one hand and morbidity and mortality in COPD on the other hand. Methods: Therapy adherence to ICSs and tiotropium over a 3-year period of, respectively, 635 and 505 patients was collected from pharmacy records. It was expressed as percentage and deemed optimal at ≥75-≤125%, suboptimal at ≥50%-<75%, and poor at <50% (underuse) or >125% (overuse)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
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