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https://www.readbyqxmd.com/read/28818147/attention-deficit-hyperactivity-disorder-and-fatal-accidents-in-aviation-medicine
#1
Tanja Laukkala, Robert Bor, Bruce Budowle, Antti Sajantila, Pooshan Navathe, Markku Sainio, Alpo Vuorio
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with symptoms of inattention and/or hyperactivity-impulsivity that interfere with functioning and/or development. ADHD occurs in about 2.5% of adults. ADHD can be an excluding medical condition among pilots due to the risk of attentional degradation and therefore impact on flight safety. Diagnosis of ADHD is complex, which complicates aeromedical assessment. This study highlights fatal accident cases among pilots with ADHD and discusses protocols to detect its presence to help to assess its importance to flight safety...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28789927/commentary-on-inherited-dna-repair-gene-mutations-in-men-with-metastatic-prostate-cancer-pritchard-cc-mateo-j-walsh-mf-de-sarkar-n-abida-w-beltran-h-garofalo-a-gulati-r-carreira-s-eeles-r-elemento-o-rubin-ma-robinson-d-lonigro-r-hussain-m-chinnaiyan-a-vinson
#2
Byron H Lee
BACKGROUND: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to warrant routine testing, the frequency of such mutations in patients with metastatic prostate cancer has not been established. METHODS: We recruited 692 men with documented metastatic prostate cancer who were unselected for family history of cancer or age at diagnosis...
August 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28770699/risk-and-protective-factors-for-mental-health-and-community-cohesion-after-the-2013-calgary-flood
#3
Erin Hetherington, Sheila McDonald, Muci Wu, Suzanne Tough
OBJECTIVE: To examine mental health and community cohesion in women living in Calgary after a natural disaster considering previously collected mental health data. METHODS: Data from an ongoing longitudinal cohort, the All Our Families study, were used to examine mental health and community cohesion 5 months after a major flood in Calgary, Canada. Participants who had completed a baseline questionnaire before the flood were eligible for inclusion in this study (N=923)...
August 3, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28742397/morbidity-in-the-mountainous-province-of-kyrgyzstan-results-from-a-population-based-cross-sectional-study
#4
Nurlan Brimkulov, Louis Louton, Salima Sydykova, Denis Vinnikov, Farida Imanalieva
Brimkulov, Nurlan, Louis Louton, Salima Sydykova, Denis Vinnikov, and Farida Imanalieva. Morbidity in the mountainous Province of Kyrgyzstan: results from a population-based cross-sectional study. High Alt Med Biol 00:000-000, 2017.-The aim of this study was to identify the main causes of using primary care facilities in the mountainous Naryn Province of Kyrgyzstan to set resources allocation priorities. We collected data on all admissions to family doctors in three Family Medical Centers (FMCs) in Naryn Province: (1) the city of Naryn (2200 meters above sea level [MASL]); (2) the town of At-Bashy (3200 MASL); and the town of Kochkor (1800 MASL) by using an original questionnaire during one full week (5 days) in spring 2016...
July 25, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28742282/med-resulting-from-recessively-inherited-mutations-in-the-gene-encoding-calcium-activated-nucleotidase-cant1
#5
Karthika Balasubramanian, Bing Li, Deborah Krakow, Lisette Nevarez, Patric J Ho, Julia A Ainsworth, Deborah A Nickerson, Michael J Bamshad, LaDonna Immken, Ralph S Lachman, Daniel H Cohn
Multiple Epiphyseal Dysplasia (MED) is a relatively mild skeletal dysplasia characterized by mild short stature, joint pain, and early-onset osteoarthropathy. Dominantly inherited mutations in COMP, MATN3, COL9A1, COL9A2, and COL9A3, and recessively inherited mutations in SLC26A2, account for the molecular basis of disease in about 80-85% of the cases. In two families with recurrent MED of an unknown molecular basis, we used exome sequencing and candidate gene analysis to identify homozygosity for recessively inherited missense mutations in CANT1, which encodes calcium-activated nucleotidase 1...
September 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28724296/the-influence-of-relationships-on-the-meaning-making-process-patients-perspectives
#6
Danetta Hendricks Sloan, Karlynn BrintzenhofeSzoc, Erin Mistretta, M Jennifer Cheng, Ann Berger
BACKGROUND: The diagnosis of a chronic or life limiting illness followed by treatment often requires an adjustment to life goals and expectations. With added existential concerns, patients' struggle to redefine life meaning while also finding ways to alleviate any distress that may occur. Central to the work of many scholars, meaning making is thought to be a vital component of negotiating traumatic life events while also essential to the positive adjustment in chronic illness and healing...
July 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28720189/enhancing-the-meaningfulness-of-work-for-astronauts-on-long-duration-space-exploration-missions
#7
Thomas W Britt, Anton Sytine, Ashley Brady, Russ Wilkes, Rebecca Pittman, Kristen Jennings, Kandice Goguen
INTRODUCTION: Numerous authors have identified the stressors likely to be encountered on long duration space exploration missions (e.g., to Mars), including the possibility of significant crises, separation from family, boredom/monotony, and interpersonal conflict. Although many authors have noted that meaningful work may be beneficial for astronauts on these missions, none have detailed the sources of meaningful work for astronauts and how these sources may differ between astronauts...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28691266/empowerment-of-family-caregivers-of-adults-and-elderly-persons-a-concept-analysis
#8
Sayori Sakanashi, Kimie Fujita
AIM: This concept analysis defined and described the components of empowerment of family caregivers who care for adults and the elderly. METHODS: Rodgers evolutionary method of concept analysis was used. Data sources included Pub Med, CINAHL, Scopus, and Igaku Chuo Zasshi. Thirty articles published between 1995 and 2015 focusing on the empowerment of family caregivers providing care to adults and the elderly were selected. RESULT: The analysis reveals 6 attributes, 5 antecedents, and 5 consequences...
July 9, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28685811/homozygosity-for-a-missense-variant-in-comp-gene-associated-with-severe-pseudoachondroplasia
#9
Muhammad Tariq, Tahir Naeem Khan, Lars Lundin, Muhammad Jameel, Torsten Lönnerholm, Shahid Mahmood Baig, Niklas Dahl, Joakim Klar
The phenotypic spectrum associated with heterozygous mutations in cartilage oligomeric matrix protein gene (COMP) range from a mild form of multiple epiphyseal dysplasia (MED) to pseudoachondroplasia (PSACH). However, the phenotypic effect from biallelic COMP variants is unclear. We investigated a large consanguineous Pakistani family with a severe form of PSACH in two individuals. Another 14 family members presented with a mild PSACH phenotype similar to MED. Using exome sequencing and subsequent segregation analysis, we identified homozygosity for a COMP missense variant (c...
July 7, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28670906/feasibility-and-acceptability-of-a-mediterranean-style-diet-intervention-to-reduce-cardiovascular-risk-for-low-income-hispanic-american-women
#10
Yaniré Estrada Del Campo, Laura Cubillos, Maihan B Vu, Aurelia Aguirre, Daniel S Reuland, Thomas C Keyserling
OBJECTIVE: Evidence for the cardioprotective effects of a Mediterranean-style (Med-style) diet is strong, however few Med-style dietary interventions have been developed for and tested among Hispanic Americans (HAs), especially younger HAs of reproductive age whose dietary habits may strongly influence dietary intake for all family members. DESIGN: We adapted a previously tested and evidence-informed lifestyle intervention to reduce CVD risk and evaluated its feasibility, acceptability, and effects on self-reported lifestyle behaviors in this study enrolling low-income HA women attending a Title X family planning clinic in eastern North Carolina...
July 1, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28661931/splicing-regulators-in-endothelial-cell-differentiation
#11
Concetta Schiano, Monica Rienzo, Amelia Casamassimi, Andrea Soricelli, Claudio Napoli
AIMS: Alternative splicing represents a key mechanism of gene regulation. Despite its role in regulating cell pluripotency and differentiation being well known, the underlining mechanisms are still poorly studied. Here, we investigated the possible involvement of splicing regulators during the different steps of endothelial cell differentiation through expression studies on human circulating progenitors. METHODS: Total RNAs were extracted from all cells and reverse-transcribed...
June 28, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28659215/how-evacuees-obtained-health-care-information-after-the-great-east-japan-earthquake-a-qualitative-interview-study
#12
Haruka Ota, Kikuko Miyazaki, Takeo Nakayama
OBJECTIVE: To explore how evacuees obtained health care information at their evacuation destinations after the Great East Japan Earthquake. METHODS: We conducted semi-structured interviews of 11 evacuees who moved to City A in Kyoto Prefecture following the Great East Japan Earthquake. The interviews explored how the evacuees obtained health care information, including the main factors of influence. The interviews were transcribed and analyzed to identify trends by using the constant comparative method...
June 29, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28623070/commentary-on-inherited-dna-repair-gene-mutations-in-men-with-metastatic-prostate-cancer-pritchard-cc-mateo-j-walsh-mf-de-sarkar-n-abida-w-beltran-h-garofalo-a-gulati-r-carreira-s-eeles-r-elemento-o-rubin-ma-robinson-d-lonigro-r-hussain-m-chinnaiyan-a-vinson
#13
Stephen J Freedland, William J Aronson
BACKGROUND: Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence of germline mutations in DNA-repair genes among men with localized prostate cancer who are unselected for family predisposition is insufficient to warrant routine testing, the frequency of such mutations in patients with metastatic prostate cancer has not been established. METHODS: We recruited 692 men with documented metastatic prostate cancer who were unselected for family history of cancer or age at diagnosis...
June 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28571777/postpartum-screening-practices-progression-to-abnormal-glucose-tolerance-and-its-related-risk-factors-in-asian-women-with-a-known-history-of-gestational-diabetes-a-systematic-review-and-meta-analysis
#14
REVIEW
Sedigheh Nouhjah, Hajieh Shahbazian, Neda Amoori, Shayesteh Jahanfar, Nahid Shahbazian, Alireza Jahanshahi, Bahman Cheraghian
AIMS: Rate of postpartum screening and progression to glucose intolerance (diabetes and/or pre-diabetes) in Asian women with prior GDM and risk factors of diversion to abnormal glucose tolerance were reviewed. MATERIALS AND METHODS: We searched Pub Med, Cochrane Library, Web of Science, EMBASE, and Ovid data base. About 1300 studies were screened and 27 articles were selected. Meta-analysis using Comprehensive Meta -Analysis software was conducted. All results were reported at the pooled ORs and 95% CI...
May 24, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28559998/a-novel-relationship-for-schizophrenia-bipolar-and-major-depressive-disorder-part-5-a-hint-from-chromosome-5-high-density-association-screen
#15
Xing Chen, Feng Long, Bin Cai, Xiaohong Chen, Gang Chen
Familial clustering of schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD) was systematically reported (Aukes, M. F. Genet Med 2012, 14, 338-341) and any two or even three of these disorders could co-exist in some families. In addition, evidence from symptomatology and psychopharmacology also imply that there are intrinsic connections between these three major disorders. A total of 56,569 single nucleotide polymorphism (SNPs) on chromosome 5 were genotyped by Affymetrix Genome-Wide Human SNP array 6...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28525923/a-national-implementation-project-to-prevent-catheter-associated-urinary-tract-infection-in-nursing-home-residents
#16
Lona Mody, M Todd Greene, Jennifer Meddings, Sarah L Krein, Sara E McNamara, Barbara W Trautner, David Ratz, Nimalie D Stone, Lillian Min, Steven J Schweon, Andrew J Rolle, Russell N Olmsted, Dale R Burwen, James Battles, Barbara Edson, Sanjay Saint
Importance: Catheter-associated urinary tract infection (UTI) in nursing home residents is a common cause of sepsis, hospital admission, and antimicrobial use leading to colonization with multidrug-resistant organisms. Objective: To develop, implement, and evaluate an intervention to reduce catheter-associated UTI. Design, Setting, and Participants: A large-scale prospective implementation project was conducted in community-based nursing homes participating in the Agency for Healthcare Research and Quality Safety Program for Long-Term Care...
August 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28518005/safety-considerations-for-medical-staff-and-patients-who-fly-over-water-in-a-helicopter-for-work-or-recreation
#17
Christopher J Brooks, Conor V MacDonald
BACKGROUND: Around 25% of people involved in a helicopter accident in water do not survive. From time to time, physicians and their medical staff are required to fly over water in a helicopter to attend one or more seriously ill patients. Many will have had little or no experience of the issues involved if the helicopter has an accident in the water. Also as Family Practitioners, Aeromedical Examiners, and Flight Surgeons, they are asked to provide advice to patients, travel agents, and airline booking agents about whether an overwater helicopter flight is advisable or not...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28516826/fatalities-from-firearm-related-injuries-in-selected-governorates-of-iraq-2010-2013
#18
Maximilian P Nerlander, Eva Leidman, Ahmed Hassan, Abdul-Salam Saleh Sultan, Syed Jaffar Hussain, Lauren B Browne, Oleg O Bilukha
BACKGROUND: In Iraq, where Islamic State of Iraq and Syria (ISIS) and other groups have contributed to escalating violence in recent years, understanding the epidemiology of intentional firearm-related fatalities is essential for public health action. METHODS: The Iraqi Ministry of Health (MoH; Baghdad, Iraq) compiles surveillance of fatal injuries in eight of Iraq's 18 governorates (Baghdad, Al-Anbar, Basrah, Erbil, Kerbala, Maysan, Ninevah, and Al-Sulaimaniya)...
May 18, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28512369/-nanopesticides-light-or-dark-side-of-the-force
#19
REVIEW
Magdalena Matysiak, Marcin Kruszewski, Lucyna Kapka-Skrzypczak
Nanotechnology has been used in many branches of industry, including agriculture, where nanomaterials are used as carriers of chemical plant protection compounds, as well as active ingredients. Meanwhile, the effects of nanopesticides exposure on the human body are unknown. Due to their occupation, farmers should be particularly monitored. This paper summarizes the use of nanoparticles in agriculture, the route of potential exposure for agricultural workers and the current state of knowledge of nanopesticides toxicity to mammalian cells...
May 16, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28512360/bullying-behavior-and-mental-health-in-healthcare-and-educational-sectors-in-kaunas-lithuania
#20
Lina Bernotaite, Vilija Malinauskiene, Palmira Leisyte
BACKGROUND: Investigations on workplace bullying in the countries of Eastern Europe are yet not too extensive. The aim of the study has been to identify the most frequent bullying behavior and to explore the associations with psychological distress and post-traumatic stress symptoms in 3 female-dominated occupations in Kaunas, Lithuania. MATERIAL AND METHODS: This crosssectional study employed 517 teachers (response rate (RR) = 71.3%), 174 family physicians (RR = 65...
May 16, 2017: Medycyna Pracy
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