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https://www.readbyqxmd.com/read/29240075/a-systematic-analysis-of-online-marketing-materials-used-by-providers-of-expanded-carrier-screening
#1
Davit Chokoshvili, Pascal Borry, Danya F Vears
PurposeExpanded carrier screening (ECS) for a large number of recessive disorders is available to prospective parents through commercial providers. This study aimed to analyze the content of marketing materials on ECS providers' websites.MethodsTo identify providers of ECS tests, we undertook a comprehensive online search, reviewed recent academic literature on commercial carrier screening, and consulted with colleagues familiar with the current ECS landscape. The identified websites were archived in April 2017, and inductive content analysis was performed on website text, brochures and educational materials, and video transcripts...
December 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29227155/using-mobile-health-to-improve-social-support-for-low-income-latino-patients-with-diabetes-a-mixed-methods-analysis-of-the-feasibility-trial-of-text-med%C3%A2-%C3%A2-fans
#2
Elizabeth Burner, Chun Nok Lam, Rebecca DeRoss, Marjorie Kagawa Singer, Michael Menchine, Sanjay Arora
BACKGROUND: Social support interventions can improve diabetes self-care, particularly for Latinos, but are time and resource intensive. Mobile health may overcome these barriers by engaging and training supporters remotely. METHODS: We conducted a randomized controlled feasibility trial of emergency department patients with diabetes to determine the feasibility of enrolling patients and supporters, acceptability of the intervention, and preliminary efficacy results to power a larger trial...
December 11, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29219637/first-cases-of-hb-agrinio-described-in-patients-from-the-republic-of-macedonia
#3
Marija Dimishkovska, Maja Kuzmanovska, Svetlana Kocheva, Kata Martinova, Oliver Karanfilski, Zlate Stojanoski, Dijana Plaseska-Karanfilska
Previous molecular analyses of α-thalassemia (α-thal) in the Republic of Macedonia have identified the following genetic defects: -α3.7 (rightward), -(α)20.5 and - -MED I deletions and Hb Icaria [α142, Term→Lys (α2), HBA2: c.427T>A] and polyadenylation signal (polyA) [AATAAA>AATGAA (α2), HBA2: c.*92A>G] point mutations. Here, we report two unrelated patients from the Romani population in the Republic of Macedonia, homozygotes for the α2-globin gene variant Hb Agrinio [α29(B10)Leu→Pro; HBA2: c...
December 8, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29209095/life-role-salience-and-subjective-well-being-among-macedonian-employees-does-family-supportive-organization-perception-moderate-this-relationship
#4
Biljana Blaževska Stoilkovska, Orhideja Šurbanovska, Ana Fritzhand, Tatjana Stojanoska Ivanova
OBJECTIVES: As many studies have shown, one of the most important tendencies of employees nowadays is to achieve work- life balance. Organizations should develop various activities and create supportive climate, within the framework of which employees will have opportunities to realize aforementioned goals which in turn would increase work productivity and work motivation. The aim of this paper was to examine how subjective well-being (life satisfaction and exhaustion) is associated with commitment to work and family roles under the conditions of strongly and weakly perceived organizational support for family life among health care professionals, teachers and bankers in Macedonia...
November 29, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29190404/sex-ed-by-brown-med-a-student-run-curriculum-and-its-impact-on-sexual-health-knowledge
#5
Erica Duh, Sheyla P Medina, Nathan Coppersmith, Naomi Adjei, Mary B Roberts, Susanna Magee
BACKGROUND AND OBJECTIVES: Risky sexual behavior among adolescents is a public health crisis. We describe a novel approach to sexual health education where medical students manage a curriculum for an entire seventh grade in one Rhode Island city to better equip students with comprehensive knowledge about sexual health. METHODS: Medical students were trained to teach 12 sessions to seventh-grade students under the supervision of the classroom teacher using a curriculum designed by medical students and faculty (modeled on the Family Life and Sexual Health [FLASH] curriculum but tailored to meet the community's needs)...
November 2017: Family Medicine
https://www.readbyqxmd.com/read/29162753/assessment-of-pain-in-the-elderly-a-literature-review
#6
REVIEW
Yoon-Sook Kim, Jae-Min Park, Yeon-Sil Moon, Seol-Heui Han
BACKGROUND: Pain perception is highly subjective, and effective pain management can be challenging in the elderly. We aimed to identify a set of practical measures that could be used to assess pain in elderly patients with or without cognitive impairment, as the first step towards effectively managing their pain. METHODS: We used the PRISMA guidelines for this literature review. Two reviewers independently assessed titles, abstracts and full-text articles, and a third reviewer resolved any disagreements...
July 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29158913/an-implementation-effectiveness-hybrid-trial-of-video-based-family-therapy-for-peripartum-depression-in-home-visited-mothers-a-protocol-for-a-pilot-trial
#7
Fallon Cluxton-Keller, Craig L Donnelly, Melony Williams, Jennifer Buteau, Patricia Stolte, Maggie Monroe-Cassel, Martha L Bruce
Background: The Federal Maternal, Infant, and Early Childhood Home Visiting (HV) Program serves over 100,000 vulnerable families at risk for child abuse in the USA and aims to improve many outcomes, including maternal mental health (HRSA's Federal Home Visiting Program: partnering with parents to help children succeed, 2017). Most clients are insured by Medicaid, and about 40% are adolescent mothers (pregnant and post-delivery) (The mother and infant home visiting program evaluation: early findings on the Maternal, Infant, and Early Childhood Home Visiting Program, 2015)...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29110804/association-between-marijuana-use-and-sexual-frequency-in-the-united-states-a-population-based-study
#8
Andrew J Sun, Michael L Eisenberg
BACKGROUND: Marijuana use is increasingly prevalent in the United States. Effects of marijuana use on sexual function are unclear, with contradictory reports of enhancement and detriment existing. AIM: To elucidate whether a relation between marijuana use and sexual frequency exists using a nationally representative sample of reproductive-age men and women. METHODS: We analyzed data from cycle 6 (2002), cycle 7 (2006-2010), and continuous survey (2011-2015) administrations of the National Survey of Family Growth, a nationally representative cross-sectional survey...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29110803/sexual-dysfunction-in-primary-care-an-exploratory-descriptive-analysis-of-medical-record-diagnoses
#9
Katie M Heiden-Rootes, Joanne Salas, Sarah Gebauer, Matthew Witthaus, Jeffrey Scherrer, Kristin McDaniel, Dasha Carver
BACKGROUND: The prevalence of sexual dysfunction (SDx) diagnoses in primary care settings is not well known, which is a concern because of the high prevalence of comorbid chronic health conditions in patients diagnosed with SDx. AIM: To explore the relation of SDx diagnosis, chronic health conditions, and prescription medications commonly associated with SDx for men and women in primary care using medical records diagnoses. METHODS: Exploratory descriptive analyses were used to interpret secondary data from a primary care patient database...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29090069/the-frequency-and-importance-of-common-%C3%AE-globin-gene-deletions-among-%C3%AE-thalassemia-carriers-in-an-iranian-population
#10
Azam Moosavi, Ali M Ardekani
BACKGROUND: β-thalassemia is the most common monogenic disorder in Iran, and one of the challenges in the screening of the carriers is the coinheritance of α-thalassemia mutations. In the view of high prevalence of α-thalassemia mutations in many parts of the country, the aim of this study was to determine the carrier frequency of common alpha deletions, as a secondary modifier in clinical manifestations of beta thalassemia, in known beta-thalassemia carriers and some hematology parameter changes...
October 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29056100/international-adoption-of-children-surviving-the-haitian-earthquake
#11
Julie Pascal, Marion Décombas-Marion, Véronique Poirier, Alexandre Lautrette, Emilie Rigal, Julie Sciauvaud, Bruno Pereira, André Labbe, Olivier Lesens
OBJECTIVE: To evaluate resilience and frequency of behavioral symptoms in Haitian children internationally adopted before and after the earthquake of January 12, 2010. METHODS: We conducted a retrospective quantitative study in 40 Haitian children. Families were also asked to participate in a qualitative study (individual interview at 18-24 months after the earthquake) and to complete State-Trait Anxiety Inventory (STAI) and STAI for children (STAI-C) questionnaires...
October 23, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29052652/types-of-work-related-behavior-and-experiences-and-stress-coping-strategies-among-single-mothers-and-mothers-in-relationships-differentiating-role-of-work-satisfaction
#12
Elżbieta Napora, Anna Andruszkiewicz, Małgorzata Anna Basińska
OBJECTIVES: The purpose of the study has been to describe functioning of single and mothers in relationships (married or in informal relationships) at work and verify if the declared degree of work satisfaction differentiates types of behavior at work and stress coping strategies in both groups of mothers. MATERIAL AND METHODS: The study was conducted on equal samples of single mothers (N = 186) and mothers from 2-parent families (N = 186) using Latack Coping Scale that measures work-related stress coping strategies, the AVEM (Arbeitsbezogenes Verhaltens- und Erlebensmuster - Work-Related Behavior and Experience Pattern) questionnaire, and a survey...
October 18, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29024831/multiple-slc26a2-mutations-occurring-in-a-three-generational-family
#13
Ana Coral Barreda-Bonis, Jimena Barraza-García, Manuel Parrón, Ignacio Pastor, Karen E Heath, Isabel González-Casado
Multiple epiphyseal dysplasias (MED) are a group of heterogeneous skeletal dysplasias, which share a common phenotype: short stature, skeletal deformities, joint pain and early onset osteoarthritis. Mutations in COMP account for approximately half of autosomal dominant MED cases whilst SLC26A2 mutations account for ∼25% of the recessive cases in the Caucasian population. We present here an interesting family, which was thought to initially have an autosomal dominant skeletal dysplasia. Using a targeted sequencing skeletal dysplasia panel, the proband was found to be a compound heterozygote for two mutations in SLC26A2, one novel mutation, p...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29024770/biochemical-biological-and-molecular-characterization-of-an-l-amino-acid-oxidase-laao-purified-from-bothrops-pictus-peruvian-snake-venom
#14
Fanny Lazo, Dan E Vivas-Ruiz, Gustavo A Sandoval, Edith F Rodríguez, Edgar E G Kozlova, F Costal-Oliveira, Carlos Chávez-Olórtegui, Ruperto Severino, Armando Yarlequé, Eladio F Sanchez
An L-amino acid oxidase from Peruvian Bothrops pictus (Bpic-LAAO) snake venom was purified using a combination of size-exclusion and ion-exchange chromatography. Bpic-LAAO is a homodimeric glycosylated flavoprotein with molecular mass of ∼65 kDa under reducing conditions and ∼132 kDa in its native form as analyzed by SDS-PAGE and gel filtration chromatography, respectively. N-terminal amino acid sequencing showed highly conserved residues in a glutamine-rich motif related to binding substrate. The enzyme exhibited optimal activity towards L-Leu at pH 8...
December 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28991270/how-job-and-family-demands-impact-change-in-perceived-stress-a-dyadic-study
#15
Ewelina Smoktunowicz, Roman Cieślak
OBJECTIVES: The aim of this two-wave study has been to test the spillover and crossover of job and family demands on changes in perceived stress at work and in the family. Specifically, we proposed that demands from one domain (work or family) spilled over to another domain through interrrole conflict (work-family/family-work conflict) and context-specific self-efficacy. Additionally, we hypothesized that changes in perceived stress were impacted not only by a person's own demands through interrole conflict but also by the demands of one's significant other, in the process of crossover...
October 9, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28987451/smoking-prevention-in-children-and-adolescents-a-systematic-review-of-individualized-interventions
#16
REVIEW
Lindsay R Duncan, Erin S Pearson, Ralph Maddison
OBJECTIVE: This study systematically reviewed the literature to determine what type of cognitive-behavioral based interventions administered outside of formal school settings effectively prevent smoking initiation among children and adolescents. METHODS: Applying the PRISMA guidelines we searched MEDLINE, PsycINFO, CINHAL, Pub Med, SCOPUS, and Sport Discus. Article review, data extraction, and assessment of risk of bias were conducted by two independent reviewers...
September 21, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28976053/collaborative-care-using-six-thinking-hats-for-decision-making
#17
Jane Marie Cioffi
AIM: To apply six thinking hats technique for decision making in collaborative care. BACKGROUND: In collaborative partnerships, effective communications need to occur in patient, family, and health care professional meetings. The effectiveness of these meetings depends on the engagement of participants and the quality of the meeting process. The use of six thinking hats technique to engage all participants in effective dialogue is proposed. DESIGN: Discussion paper...
October 4, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28970070/characteristics-of-subgroups-in-the-adult-baby-diaper-lover-community
#18
Brian D Zamboni
BACKGROUND: There is a lack of research on adult baby/diaper lover (ABDL) behavior, particularly from community samples. Prior studies have not examined differences between the AB and DL subgroups in the ABDL community. AIM: To explore whether endorsements of AB role-play enjoyment and ratings of sexual enjoyment during ABDL activity were related to parenting and attachment variables, negative mood states, and reported problems with ABDL and to explore differences by relationship status and by sexual orientation...
September 29, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28964710/differential-dna-methylation-in-monozygotic-twins-discordant-for-female-sexual-functioning
#19
Andrea Burri, Myriam Leupin, Timothy Spector, Zoya Marinova
BACKGROUND: Research has repeatedly suggested genetic and environmental factors in the etiology underlying female sexual dysfunction (FSD). Because sexual functioning is a highly variable trait, epigenetics could provide a promising approach to tackle the origins of FSD and consequently offer a step-change in our understanding of these problems. AIM: To identify differentially methylated CpG positions for sexual functioning in a sample of monozygotic twin pairs discordant for sexual functioning...
September 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28944055/understanding-the-links-between-resilience-and-type-2-diabetes-self-management-a-qualitative-study-in-south-australia
#20
A L Wilson, D McNaughton, S B Meyer, P R Ward
BACKGROUND: Research conducted by Ward, Muller, Tsourtos, et al. (Soc Sci Med 72(7):1140-1148, 2011) has led to the development of the psycho-social interactive model of resilience, which reveals the interaction between individual resilience factors (i.e. coping, confidence and self esteem) and external resilience environments (i.e. employment, supportive family environments and health promoting policies) in facilitating the development of resilience. This present study explored the utility of this model of resilience for understanding how people self-manage type-2 diabetes...
2017: Archives of Public Health, Archives Belges de Santé Publique
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