keyword
https://read.qxmd.com/read/38093788/a-cell-penetrating-peptide-exerts-therapeutic-effects-against-ischemic-stroke-by-mediating-the-lysosomal-degradation-of-sirtuin-5
#21
JOURNAL ARTICLE
Qian Xia, Xue Zhang, Gaofeng Zhan, Lu Zheng, Meng Mao, Yin Zhao, Yilin Zhao, Xing Li
Stroke is a major public health concern worldwide. The lack of effective therapies heightens the need for new therapeutic agents. Previous study identified sirtuin 5 (SIRT5) as a positive regulator of microglia-induced excessive neuroinflammation following ischemic stroke. Interventions targeting SIRT5 should therefore alleviate neuroinflammation and protect against ischemic stroke. Here, we synthesized a membrane-permeable peptide specifically bound to SIRT5 through a chaperone-mediated autophagy targeting motif (Tat-SIRT5-CTM) and examined its therapeutic effect in vitro and in vivo...
December 2023: MedComm
https://read.qxmd.com/read/38085519/the-expression-of-annexin-a1-in-esophageal-squamous-cell-carcinoma-and-its-association-with-the-biological-behavior-of-the-primary-human-esophageal-squamous-carcinoma-cell-line
#22
JOURNAL ARTICLE
X-J Li, J Li, Q-Q Zhang, L-P Su, Y Guo, X-L Gong, J-J Yao, L Wang, Z-Q Zhang
This study aimed to observe the differential expression of Annexin-A1 in esophageal squamous cell carcinoma (ESCC) and explored the effect of small interfering ribonucleic acid (RNAi)-Annexin-A1 on the biological behavior of CE81T-0 cells. An immunohistochemical approach was used to detect the expression of Annexin-A1 in 86 pairs of ESCC samples. Quantitative reverse transcription polymerase chain reaction was used to detect the expression of Annexin-A1 in CE81T-0 and CE81T-4 cells, and the expression of Annexin-A1 in CE81T-0 cells was knocked out by RNAi...
October 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/38076917/loss-of-myeloid-cell-specific-%C3%AE-2-adrenergic-receptor-expression-ameliorates-cardiac-function-and-remodeling-after-acute-ischemia
#23
Tapas K Nayak, Anamika Bajpai, Viren Patwa, Rhonda L Carter, Nitya Enjamuri, Erhe Gao, Yang K Xiang, Douglas G Tilley
Myeloid cells, including neutrophils, monocytes and macrophages, accumulate quickly after ischemic injury in the heart where they play integral roles in the regulation of inflammation and repair. We previously reported that deletion of β2-adrenergic receptor (β2AR) in all cells of hematopoietic origin resulted in generalized disruption of immune cell responsiveness to injury, but with unknown impact on myeloid cells specifically. To investigate this, we crossed floxed β2AR (F/F) mice with myeloid cell-expressing Cre (LysM-Cre) mice to generate myeloid cell-specific β2AR knockout mice (LB2) and subjected them to myocardial infarction (MI)...
November 27, 2023: bioRxiv
https://read.qxmd.com/read/38073229/engineering-extracellular-vesicles-with-macrophage-membrane-fusion-for-ameliorating-imiquimod-induced-psoriatic-skin-inflammation
#24
JOURNAL ARTICLE
Zeng Wang, Zhizhen Qin, Jiadie Wang, Xinqi Xu, Mengxin Zhang, Yuyue Liang, Yukun Huang, Zengyang Yu, Yu Gong, Luxian Zhou, Yiran Qiu, Minglu Ma, Dan Li, Bin Li
INTRODUCTION: Herein, we developed an engineered extracellular vehicle (EV)-based method for ameliorating inflammatory responses in psoriasis. METHODS: EVs, derived from annexin A1 (ANXA1) overexpressing T cells, were co-extruded with M2 macrophage membrane to obtain engineered EVs. In vitro , the effect of engineered EVs on macrophage polarization was evaluated by real-time PCR. In imiquimod (IMQ)-induced psoriasis-like mouse model, the efficacy of engineered EVs in ameliorating psoriatic inflammation was evaluated by Psoriasis Area and Severity Index (PASI) score and immunohistochemistry staining after subcutaneous injection of EVs...
December 2023: Journal of Dermatological Treatment
https://read.qxmd.com/read/38061137/the-inhibitory-effects-of-epigallocatechin-3-gallate-on-calcium-oxalate-monohydrate-crystal-growth-aggregation-and-crystal-cell-adhesion
#25
JOURNAL ARTICLE
Rattiyaporn Kanlaya, Rasiyakapat Kuljiratansiri, Paleerath Peerapen, Visith Thongboonkerd
Epigallocatechin-3-gallate (EGCG), a predominant phytochemical in tea plant, has been reported to prevent kidney stone formation but with vague mechanism. We investigated modulatory effects of EGCG (at 0.1-100 µM) on calcium oxalate monohydrate (COM) crystals at various stages of kidney stone development. EGCG significantly increased crystal size (at 1-100 µM), but decreased crystal number (at 10-100 µM), resulting in unchanged crystal mass and volume. Interestingly, EGCG at 10-100 µM caused morphological change of the crystals from typical monoclinic prismatic to coffee-bean-like shape, which represented atypical/aberrant form of COM as confirmed by attenuated total reflection - Fourier transform infrared (ATR-FTIR) spectroscopy...
December 6, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38059331/hpv-negative-head-and-neck-cancers-with-adverse-pathological-features-carry-specific-molecular-changes-that-are-associated-with-survival
#26
JOURNAL ARTICLE
Hugh Andrew Jinwook Kim, Peter Y F Zeng, Matthew Cecchini, Mushfiq Hassan Shaikh, Francisco Laxague, Xiaoxiao Deng, Laura Jarycki, Sarah Elizabeth Belle Ryan, Alice Dawson, Mu Han Liu, David A Palma, Krupal Patel, Neil Mundi, John W Barrett, Joe S Mymryk, Paul C Boutros, Anthony C Nichols
BACKGROUND: Adverse pathological features following surgery in head and neck squamous cell carcinoma (HNSCC) are strongly associated with survival and guide adjuvant therapy. We investigated molecular changes associated with these features. METHODS: We downloaded data from the Cancer Genome Atlas and Cancer Proteome Atlas HNSCC cohorts. We compared tumors positive versus negative for perineural invasion (PNI), lymphovascular invasion (LVI), extracapsular spread (ECS), and positive margins (PSM), with multivariable analysis...
December 7, 2023: Head & Neck
https://read.qxmd.com/read/38049523/glioma-derived-anxa1-suppresses-the-immune-response-to-tlr3-ligands-by-promoting-an-anti-inflammatory-tumor-microenvironment
#27
JOURNAL ARTICLE
Yu Zheng, Haihui Jiang, Naixue Yang, Shaoping Shen, Daosheng Huang, Lemei Jia, Jing Ling, Longchen Xu, Mingxiao Li, Kefu Yu, Xiaohui Ren, Yong Cui, Xun Lan, Song Lin, Xin Lin
A highly immunosuppressive tumor microenvironment (TME) and the presence of the blood‒brain barrier are the two major obstacles to eliciting an effective immune response in patients with high-grade glioma (HGG). Here, we tried to enhance the local innate immune response in relapsed HGG by intracranially injecting poly(I:C) to establish a robust antitumor immune response in this registered clinical trial (NCT03392545). During the follow-up, 12/27 (44.4%) patients who achieved tumor control concomitant with survival benefit were regarded as responders in our study...
December 4, 2023: Cellular & Molecular Immunology
https://read.qxmd.com/read/37992916/the-annexin-a1-mimetic-rtp-026-promotes-acute-cardioprotection-through-modulation-of-immune-cell-activation
#28
JOURNAL ARTICLE
Jianmin Chen, Silvia Oggero, Chiara Cecconello, Jesmond Dalli, Hedayatullah Hayat, Ahmad Hjiej Andaloussi, Samra Sanni, Thomas En Jonassen, Mauro Perretti
AIMS: The cardio-protective and immuno-regulatory properties of RTP-026, a synthetic peptide that spans the Annexin-A1 (AnxA1) N-terminal region, were tested in rat acute myocardial infarction. METHODS AND RESULTS: In vitro, selective activation of formyl-peptide receptor type 2 (FPR2) by RTP-026 occurred with apparent EC50 in the 10-30 nM range. With human primary cells, RTP-026 counteracted extension of neutrophil life-span and augmented phagocytosis of fluorescent E...
December 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37987258/possible-role-of-annexin-a1-fpr2-pathway-in-cox2-nlrp3-inflammasome-regulation-in-alveolar-bone-cells-of-estrogen-deficient-female-rats-with-diabetes-mellitus
#29
JOURNAL ARTICLE
Gisela Rodrigues Da Silva Sasso, Paulo Sérgio Cerri, Estela Sasso-Cerri, Manuel Jesus Simões, Cristiane Damas Gil, Rinaldo Florencio-Silva
BACKGROUND: Annexin A1 (ANXA1) and the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome play important roles in bone remodeling. However, expression profiles of these factors in bone cells under diabetes mellitus (DM) and estrogen-deficient conditions are poorly understood. This study investigated the immunoexpression of ANXA1 and its formyl peptide receptor 2 (FPR2), as well as NLRP3 inflammasome mediators, during remodeling of the alveolar process in diabetic and estrogen-deficient rats...
November 21, 2023: Journal of Periodontology
https://read.qxmd.com/read/37976974/the-interplay-between-associated-proteins-redox-state-and-ca-2-in-the-intraluminal-er-compartment-regulates-the-ip-3-receptor
#30
REVIEW
Jan B Parys, Fernanda O Lemos
There have been in the last three decades repeated publications indicating that the inositol 1,4,5-trisphosphate receptor (IP3 R) is regulated not only by cytosolic Ca2+ but also by intraluminal Ca2+ . Although most studies indicated that a decreasing intraluminal Ca2+ level led to an inhibition of the IP3 R, a number of publications reported exactly the opposite effect, i.e. an inhibition of the IP3 R by high intraluminal Ca2+ levels. Although intraluminal Ca2+ -binding sites on the IP3 Rs were reported, a regulatory role for them was not demonstrated...
November 10, 2023: Cell Calcium
https://read.qxmd.com/read/37954869/expression-profiles-of-glucocorticoid-inducible-proteins-in-human-papilloma-virus-related-oropharyngeal-squamous-cell-carcinoma
#31
JOURNAL ARTICLE
Mahmood S Mozaffari, Rafik Abdelsayed, Sahar Emami, Sravan Kavuri
INTRODUCTION: Human papillomavirus virus-related oropharyngeal squamous cell carcinoma (HPV-OPSCC) comprises a significant portion of head and neck cancers. Several glucocorticoid-inducible proteins play important roles in pathogenesis of some cancers but their status and roles in HPV-OPSCC remain elusive; these include the glucocorticoid-induced leucine zipper (GILZ), Annexin-A1 and serum glucocorticoid-regulated kinase-1 (SGK-1). METHODS: We determined expression profiles of these proteins, using immunohistochemistry, in archived biopsy samples of patients diagnosed with HPV-OPSCC; samples of non-cancer oral lesions (e...
2023: Front Oral Health
https://read.qxmd.com/read/37927194/annexin-a1-may-contribute-to-the-morphological-changes-in-podocytes-by-mediating-endocytic-vesicle-fusion-and-transport-via-promotion-of-snare-assembly-in-idiopathic-membranous-nephropathy
#32
JOURNAL ARTICLE
Lei Song, Wen Shen, Le Wang, Jianling Song, Weiping Tu, Ben Ke, Xiangdong Fang
BACKGROUND: Annexin A1 is a membrane-associated calcium-binding protein that participates in the progression of many diseases by facilitating vesicle aggregation. It has been documented that reducing vesicle formation alleviates podocyte injury and albuminuria in idiopathic membranous nephropathy (IMN). However, the role of Annexin A1 (ANXA1) in IMN is unknown. METHODS: Electron microscopy was used to observe the numbers of vesicles in podocytes. The expression of ANXA1 in IMN was investigated by bioinformatics analysis...
November 5, 2023: Nephrology
https://read.qxmd.com/read/37915594/mfge-8-identified-in-fetal-mesenchymal-stromal-cell-derived-exosomes-ameliorates-acute-hepatic-failure-pathology
#33
JOURNAL ARTICLE
Adriana Psaraki, Dimitra Zagoura, Lydia Ntari, Manousos Makridakis, Christina Nikokiraki, Ourania Trohatou, Konstantina Georgila, Christos Karakostas, Ioanna Angelioudaki, Anastasios G Kriebardis, Roberto Gramignioli, Stratigoula Sakellariou, Maria Xilouri, Aristides G Eliopoulos, Antonia Vlahou, Maria G Roubelakis
Liver transplantation is the gold-standard therapy for acute hepatic failure (AHF) with limitations related to organ shortage and life-long immunosuppressive therapy. Cell therapy emerges as a promising alternative to transplantation. We have previously shown that IL-10 and Annexin-A1 released by amniotic fluid human mesenchymal stromal cells (AF-MSCs) and their hepatocyte progenitor-like (HPL) or hepatocyte-like (HPL) cells induce liver repair and downregulate systemic inflammation in a CCl4 -AHF mouse model...
November 17, 2023: IScience
https://read.qxmd.com/read/37908731/tat-nts-peptide-protects-neurons-against-cerebral-ischemia-reperfusion-injury-via-anxa1-sumoylation-in-microglia
#34
JOURNAL ARTICLE
Huijuan Zhou, Lulu Yan, Hezhou Huang, Xing Li, Qian Xia, Lu Zheng, Bin Shao, Qian Gao, Ning Sun, Jing Shi
Rationale: Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke. Many studies have emphasized a well-established function of Annexin-A1 (ANXA1) in the immune system, including the regulation of microglial activation. Nevertheless, few therapeutic interventions targeting ANXA1 in microglia for ischemic stroke have been conducted. In the present study, Tat-NTS, a small peptide developed to prevent ANXA1 from entering the nucleus, was utilized...
2023: Theranostics
https://read.qxmd.com/read/37906427/shotgun-proteomic-based-approach-with-a-q-exactive-hybrid-quadrupole-orbitrap-high-resolution-mass-spectrometer-for-protein-adductomics-on-a-3d-human-brain-tumor-neurospheroid-culture-model-the-identification-of-adduct-formation-in-calmodulin-dependent-protein
#35
JOURNAL ARTICLE
Kaouthar Louati, Amina Maalej, Fatma Kolsi, Rim Kallel, Yassine Gdoura, Mahdi Borni, Leila Sellami Hakim, Rania Zribi, Sirine Choura, Sami Sayadi, Mohamed Chamkha, Basma Mnif, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Fathi Safta
Pesticides are increasingly used in combinations in crop protection, resulting in enhanced toxicities for various organisms. Although protein adductomics is challenging, it remains a powerful bioanalytical tool to check environmental exposure and characterize xenobiotic adducts as putative toxicity biomarkers with high accuracy, facilitated by recent advances in proteomic methodologies and a mass spectrometry high-throughput technique. The present study aims to predict the potential neurotoxicity effect of imidacloprid and λ-cyhalothrin insecticides on human neural cells...
October 31, 2023: Journal of Proteome Research
https://read.qxmd.com/read/37898455/sericin-and-melatonin-mitigate-diethylnitrosamine-instigated-testicular-impairment-in-mice-implications-of-oxidative-stress-spermatogenesis-steroidogenesis-and-modulation-of-nrf2-wt1-sf-1-signaling-pathways
#36
JOURNAL ARTICLE
Esraa S Habiba, Sahar A Harby, Norhan S El-Sayed, Eman M Omar, Basant A Bakr, Maria Augustyniak, Lamia M El-Samad, Mohamed A Hassan
AIMS: This study aimed to investigate the therapeutic influence of combination therapy with sericin and melatonin on attenuating diethylnitrosamine (DEN)-instigated testicular dysfunction in mice and defining the molecular mechanisms involved in orchestrating redox signaling pathways and restoring spermatogenesis and steroidogenesis. MATERIALS AND METHODS: Different groups of male Swiss albino mice were established and intraperitoneally injected with respective drugs...
October 26, 2023: Life Sciences
https://read.qxmd.com/read/37877496/anxa1sp-attenuates-sepsis-induced-myocardial-injury-by-promoting-mitochondrial-biosynthesis-and-inhibiting-oxidative-stress-and-autophagy-via-sirt3-upregulation
#37
JOURNAL ARTICLE
Song Qin, Ying-Cong Ren, Jun-Ya Liu, Wen-Bo Chen, Bao Fu, Jie Zheng, Xiao-Yun Fu
Sepsis-induced myocardial injury is one of the most difficult complications of sepsis in intensive care units. Annexin A1 (ANXA1) short peptide (ANXA1sp) protects organs during the perioperative period. However, the protective effect of ANXA1sp against sepsis-induced myocardial injury remains unclear. We aimed to explore the protective effects and mechanisms of ANXA1sp against sepsis-induced myocardial injury both in vitro and in vivo. Cellular and animal models of myocardial injury in sepsis were established with lipopolysaccharide...
October 25, 2023: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/37867938/annexin-a1-exerts-analgesic-effect-in-a-mouse-model-of-medication-overuse-headache
#38
JOURNAL ARTICLE
Zihua Gong, Chunxiao Yang, Wei Dai, Shuai Miao, Yingyuan Liu, Zhiyang Jiao, Bozhi Li, Wei Xie, Wei Zhao, Xun Han, Shengyuan Yu, Zhao Dong
Medication overuse headache (MOH) is a serious global condition. The interaction between headache attacks and medication overuse complicates the understanding of its pathophysiology. In this study, we developed a preclinical MOH model that incorporates these two key factors by overusing rizatriptan benzoate (RIZ, 4 mg/kg, i.g.) in a glyceryl trinitrate (GTN, 10 mg/kg, i.p.) induced chronic migraine mouse model. We observed that RIZ overuse aggravated GTN-induced cutaneous allodynia and caused a prolonged state of latent sensitization...
November 17, 2023: IScience
https://read.qxmd.com/read/37833989/proteomics-reveals-mrna-regulation-and-the-action-of-annexins-in-thyroid-cancer
#39
JOURNAL ARTICLE
Margarida Coelho, João Capela, Sandra I Anjo, João Pacheco, Margarida Sá Fernandes, Isabel Amendoeira, John G Jones, Luís Raposo, Bruno Manadas
Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic...
September 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37827221/decreased-oxidative-stress-response-and-oxidant-detoxification-of-skin-during-aging
#40
JOURNAL ARTICLE
Xixia Dai, Yibo Hu, Ling Jiang, Li Lei, Chuhan Fu, Songjiang Wu, Xiaolin Zhang, Lu Zhu, Fan Zhang, Jing Chen, Qinghai Zeng
Oxidative stress plays an important role in the skin aging process; however, the mechanisms are not fully elucidated. Especially the changes in various types of skin cells with aging and the key oxidative stress-related genes that play a regulatory role are not clear. In this study, single-cell RNA sequencing data and microarray transcriptome data were used to explore the changes in oxidative stress response and oxidant detoxification capacity of skin cells during aging and oxidative stress-related genes potentially involved in regulating skin aging were searched...
October 10, 2023: Mechanisms of Ageing and Development
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