Hugh Andrew Jinwook Kim, Peter Y F Zeng, Matthew Cecchini, Mushfiq Hassan Shaikh, Francisco Laxague, Xiaoxiao Deng, Laura Jarycki, Sarah Elizabeth Belle Ryan, Alice Dawson, Mu Han Liu, David A Palma, Krupal Patel, Neil Mundi, John W Barrett, Joe S Mymryk, Paul C Boutros, Anthony C Nichols
BACKGROUND: Adverse pathological features following surgery in head and neck squamous cell carcinoma (HNSCC) are strongly associated with survival and guide adjuvant therapy. We investigated molecular changes associated with these features. METHODS: We downloaded data from the Cancer Genome Atlas and Cancer Proteome Atlas HNSCC cohorts. We compared tumors positive versus negative for perineural invasion (PNI), lymphovascular invasion (LVI), extracapsular spread (ECS), and positive margins (PSM), with multivariable analysis...
December 7, 2023: Head & Neck